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Marjorie C L C Freire, Laércio Pol-Fachin, Danilo F Coêlho, Isabelle F T Viana, Tereza Magalhães, Marli T Cordeiro, Nico Fischer, Felix F Loeffler, Thomas Jaenisch, Rafael F Franca, Ernesto T A Marques, Roberto D Lins
B-cell epitope sequences from Zika virus (ZIKV) NS1 protein have been identified using epitope prediction tools. Mapping these sequences onto the NS1 surface reveals two major conformational epitopes and a single linear one. Despite an overall average sequence identity of ca. 55% between the NS1 from ZIKV and the four dengue virus (DENV) serotypes, epitope sequences were found to be highly conserved. Nevertheless, nonconserved epitope-flanking residues are responsible for a dramatically divergent electrostatic surface potential on the epitope regions of ZIKV and DENV2 serotypes...
July 31, 2017: ACS Omega
Youki Ueda, Weilin Gu, Hiromichi Dansako, Hye-Sook Kim, Sayaka Yoshizaki, Nobuaki Okumura, Tomohiro Ishikawa, Hironori Nishitsuji, Fumihiro Kato, Takayuki Hishiki, Shinya Satoh, Koji Ishii, Michiaki Masuda, Kunitada Shimotohno, Masanori Ikeda, Nobuyuki Kato
The chemically synthesized endoperoxide compound N-89 and its derivative N-251 were shown to have potent antimalarial activity. We previously demonstrated that N-89 and N-251 potently inhibited the RNA replication of hepatitis C virus (HCV), which belongs to the Flaviviridae family. Since antimalarial and anti-HCV mechanisms have not been clarified, we were interested whether N-89 and N-251 possessed the activity against viruses other than HCV. In this study, we examined the effects of N-89 and N-251 on other flaviviruses (dengue virus and Japanese encephalitis virus) and hepatitis viruses (hepatitis B virus and hepatitis E virus)...
September 2018: Biochemistry and Biophysics Reports
Hao Yan, Zheyuan Ding, Juying Yan, Wenwu Yao, Junhang Pan, Zhangnv Yang, Xiuyu Lou, Haiyan Mao, Junfen Lin, Jimin Sun, Juan Hou, Haocheng Wu, Chen Wu, Yanjun Zhang
Dengue, a mosquito-borne disease caused by the dengue virus (DV), has been recognized as a global public health threat. In 2017, an unexpected dengue outbreak occurred in Zhejiang, China. To clarify and characterize the causative agent of this outbreak, data on dengue fever cases were collected from the China Information System for Disease Control and Prevention in Zhejiang province for subsequent epidemiological analysis. A total of 1,229 cases were reported, including 1,149 indigenous and 80 imported cases...
2018: Frontiers in Cellular and Infection Microbiology
Laura Sinigaglia, Ségolène Gracias, Elodie Décembre, Matthieu Fritz, Daniela Bruni, Nikaïa Smith, Jean-Philippe Herbeuval, Annette Martin, Marlène Dreux, Frédéric Tangy, Nolwenn Jouvenet
Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast, cells infected with HCV and DENV potently stimulate pDCs via short-range delivery of viral RNAs, which are either packaged within immature virions or secreted exosomes. We report that cells infected with Yellow fever virus (YFV), the prototypical flavivirus, stimulated pDCs to produce IFNs in a TLR7- and cell contact- dependent manner...
July 18, 2018: Scientific Reports
Elodie Clain, Laura Sinigaglia, Andrea Cristine Koishi, Olivier Gorgette, Gilles Gadea, Wildriss Viranaicken, Pascale Krejbich-Trotot, Patrick Mavingui, Philippe Desprès, Claudia Nunes Duarte Dos Santos, Pascale Guiraud, Nolwenn Jouvenet, Chaker El Kalamouni
The mosquito-borne Zika virus (ZIKV) belongs to the flavivirus genus of the Flaviviridae family. Contemporary epidemic strains of ZIKV are associated with congenital malformations in infants, including microcephaly, as well as Guillain-Barré syndrome in adults. A risk of human-to-human transmission of ZIKV is also well documented. A worldwide research effort has been undertaken to identify safe and effective strategies to prevent or treat ZIKV infection. We show here that extract from Aphloia theiformis, an edible endemic plant from Indian Ocean islands, exerts a potent antiviral effect against ZIKV strains of African and Asian lineages, including epidemic strains...
July 18, 2018: Scientific Reports
Riccardo Moretti, Pei-Shi Yen, Vincent Houé, Elena Lampazzi, Angiola Desiderio, Anna-Bella Failloux, Maurizio Calvitti
Among the strategies targeting vector control, the exploitation of the endosymbiont Wolbachia to produce sterile males and/or invasive females with reduced vector competence seems to be promising. A new Aedes albopictus transinfection (ARwP-M) was generated by introducing wMel Wolbachia in the ARwP line which had been established previously by replacing wAlbA and wAlbB Wolbachia with the wPip strain. Various infection and fitness parameters were studied by comparing ARwP-M, ARwP and wild-type (SANG population) Ae...
July 18, 2018: PLoS Neglected Tropical Diseases
Maria Aparecida de Oliveira, Marta Inenami, Rosangela Maria Gasparetto da Silva, Carlos Castillo-Salgado, Helena Ribeiro
The aim of this research was to investigate the origin of imported cases of dengue in the city of Araraquara, Brazil and to describe the disease's main epidemiological characteristics. The study encompassed all confirmed cases of dengue recorded in the Information System for Notifiable Diseases (SINAN) [Sistema de Informação de Agravos de Notificação] from 1998 to 2013. Cases whose origin of infection was likely located outside Araraquara were considered imported. The epidemiological study entailed a descriptive analysis of the data, regarding the distribution of cases by sex, age, and classification of imported and autochthonous cases...
January 2018: Salud Colectiva
Ruchi Sharma, Rekha Rao, Sunil Kumar, Sheefali Mahant, Sarita Khatkar
Mosquito borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alternatives/adjuvents in pharmaceuticals, biomedical, cosmetic, food, veterinary and agriculture applications. These oils have also gained popularity and interest for prevention and treatment of various disorders...
July 17, 2018: Current Drug Discovery Technologies
William G Valiant, Tahaniyat Lalani, Heather C Yun, Anjali Kunz, Timothy H Burgess, Joseph J Mattapallil
Zika virus infection in a dengue virus-naïve subject was associated with the induction of high levels of cross-reactive binding antibodies. These responses were, however, largely non-neutralizing and displayed a capacity to enhance dengue infection in vitro at significantly low dilution (1:10). In contrast, a subject who had high levels of neutralizing antibodies against both dengue and Zika viruses enhanced infection at a dilution of 1:10 000. These results suggest that high levels of dengue cross-neutralizing antibodies could potentially prevent the enhancement of dengue infection in Zika virus-convalescent individuals...
July 2018: Open Forum Infectious Diseases
Maria A Loroño-Pino, Ana Uitz-Mena, Claudia M Carrillo-Solís, Rocío J Zapata-Gil, Dora M Camas-Tec, Lourdes G Talavera-Aguilar, Rosa C Cetina-Trejo, Luis F Flores-Flores, María C Puc-Tinal, Clara Caamal-Jiménez, Guadalupe Reyes-Solís, Julián E García-Rejón, Karla Saavedra-Rodriguez, Lars Eisen, Thomas J Keefe, William C Black Iv, Barry J Beaty
Dengue, chikungunya, yellow fever, and Zika viruses transmitted by Aedes aegypti mosquitoes are major public health threats in the tropical and subtropical world. In México, construction of large tracts of "fraccionamientos" high density housing to accommodate population growth and urbanization has provided fertile ground for Ae. aegypti -transmitted viruses. We investigated the utility of pyrethroid-treated window curtains to reduce both the abundance of Ae. aegypti and to prevent dengue virus (DENV) transmission in fraccionamiento housing...
2018: Journal of Tropical Medicine
Michelle V Evans, Justine C Shiau, Nicole Solano, Melinda A Brindley, John M Drake, Courtney C Murdock
BACKGROUND: Mosquitoes are strongly influenced by environmental temperatures, both directly and indirectly via carry-over effects, a phenomenon by which adult phenotypes are shaped indirectly by the environmental conditions experienced in previous life stages. In landscapes with spatially varying microclimates, such as a city, the effects of environmental temperature can therefore lead to spatial patterns in disease dynamics. To explore the contribution of carry-over effects on the transmission of dengue-2 virus (DENV-2), we conducted a semi-field experiment comparing the demographic and transmission rates of Aedes albopictus reared on different urban land classes in the summer and autumn season...
July 17, 2018: Parasites & Vectors
Hannah E Clapham, Bridget A Wills
The complex interaction between dengue viruses and the human immune system means that development of a safe, effective dengue vaccine was never going to be simple. The only currently licenced dengue vaccine (Dengvaxia®) does, indeed, have a complex immune profile depending on recipients' immune status, meaning that use of this vaccine is not straightforward. This commentary reviews the recommendations for vaccine use to date, and discusses issues and opportunities related to the implementation of vaccination programmes in light of these recommendations...
July 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
A Wilder-Smith
No abstract text is available yet for this article.
July 16, 2018: Journal of Travel Medicine
Elodie Calvez, Laurence Mousson, Marie Vazeille, Olivia O'Connor, Van-Mai Cao-Lormeau, Françoise Mathieu-Daudé, Nicolas Pocquet, Anna-Bella Failloux, Myrielle Dupont-Rouzeyrol
BACKGROUND: In 2013, Zika virus (ZIKV) emerged in French Polynesia and spread through the Pacific region between 2013 and 2017. Several potential Aedes mosquitoes may have contributed to the ZIKV transmission including Aedes aegypti, the main arbovirus vector in the region, and Aedes polynesiensis, vector of lymphatic filariasis and secondary vector of dengue virus. The aim of this study was to analyze the ability of these two Pacific vectors to transmit ZIKV at a regional scale, through the evaluation and comparison of the vector competence of wild Ae...
July 17, 2018: PLoS Neglected Tropical Diseases
Victoria Phooi Khei Tan, Chin Fang Ngim, Erika Ziyan Lee, Amutha Ramadas, Lian Yih Pong, Joo Ing Ng, Sharifah Syed Hassan, Xuan Ye Ng, Amreeta Dhanoa
Both obesity and DENV infections are growing public health concerns that have far-ranging socioeconomic effects, especially in developing countries. Despite the increasing prevalence of these conditions, there is a scarcity of data investigating the potential relationships between these two entities. Our study aims to examine the influence of obesity on various clinical and laboratory parameters amongst patients with DENV infections. A total of 335 hospitalized patients aged >12 years who were DENV non-structural protein 1 (NS1) antigen-positive were enrolled in this study...
2018: PloS One
Hsin-Ping Chiu, Han Chiu, Chao-Fu Yang, Yi-Ling Lee, Feng-Lan Chiu, Hung-Chih Kuo, Ren-Jye Lin, Yi-Ling Lin
CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, translation inhibition and innate immune responses. So far, only one flavivirus, yellow fever virus, has been reported to be ZAP-resistant. Here, we investigated the antiviral potential of human ZAP (isoform ZAP-L and ZAP-S) against three flaviviruses, Japanese encephalitis virus (JEV), dengue virus (DENV) and Zika virus (ZIKV). Infection of JEV but not DENV or ZIKV was blocked by ZAP overexpression, and depletion of endogenous ZAP enhanced JEV replication...
July 2018: PLoS Pathogens
Rachel Lowe, Antonio Gasparrini, Cédric J Van Meerbeeck, Catherine A Lippi, Roché Mahon, Adrian R Trotman, Leslie Rollock, Avery Q J Hinds, Sadie J Ryan, Anna M Stewart-Ibarra
BACKGROUND: Over the last 5 years (2013-2017), the Caribbean region has faced an unprecedented crisis of co-occurring epidemics of febrile illness due to arboviruses transmitted by the Aedes sp. mosquito (dengue, chikungunya, and Zika). Since 2013, the Caribbean island of Barbados has experienced 3 dengue outbreaks, 1 chikungunya outbreak, and 1 Zika fever outbreak. Prior studies have demonstrated that climate variability influences arbovirus transmission and vector population dynamics in the region, indicating the potential to develop public health interventions using climate information...
July 2018: PLoS Medicine
Gabriel Yan, Long Pang, Alex R Cook, Hanley J Ho, Mar Soe Win, Ai Leng Khoo, Joshua G X Wong, Chun Kiat Lee, Benedict Yan, Roland Jureen, Siew Seen Ho, David C Lye, Paul A Tambyah, Yee Sin Leo, Dale Fisher, Jolene Oon, Natasha Bagdasarian, Angela Chow, Nares Smitasin, Louis Yi Ann Chai
Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case-control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.
August 2018: Emerging Infectious Diseases
Yew-Meng Koh, Reagan Spindler, Matthew Sandgren, Jiyi Jiang
Many time-series models for disease counts utilise information from environmental variables. We focus on weekly dengue fever (DF) incidence rates in Singapore and demonstrate the strong negative correlation between an appropriately time-lagged total weekly rainfall and DF incidence. A Bayesian neural network time-series model for predicting DF incidence which utilizes rainfall data is introduced. A comparison is made between this neural network model and a time-series model which does not use any covariate information...
July 17, 2018: International Journal of Environmental Health Research
Nicholas Amoako, Samuel Duodu, Francis E Dennis, Joseph H K Bonney, Kwaku P Asante, Juliana Ameh, Lydia Mosi, Takaya Hayashi, Eudosia E Agbosu, Deborah Pratt, Darwin J Operario, Barry Fields, Jie Liu, Eric R Houpt, George E Armah, Justin Stoler, Gordon A Awandare
We report new molecular evidence of locally acquired dengue virus infections in Ghana. We detected dengue viral RNA among children with suspected malaria by using a multipathogen real-time PCR. Subsequent sequence analysis revealed a close relationship with dengue virus serotype 2, which was implicated in a 2016 outbreak in Burkina Faso.
August 2018: Emerging Infectious Diseases
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