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https://www.readbyqxmd.com/read/28531223/dengue-in-bali-clinical-characteristics-and-genetic-diversity-of-circulating-dengue-viruses
#1
Dewi Megawati, Sri Masyeni, Benediktus Yohan, Asri Lestarini, Rahma F Hayati, Febrina Meutiawati, Ketut Suryana, Tangking Widarsa, Dewa G Budiyasa, Ngurah Budiyasa, Khin S A Myint, R Tedjo Sasmono
A high number of dengue cases are reported annually in Bali. Despite the endemicity, limited data on dengue is available for Bali localities. Molecular surveillance study was conducted to explore the clinical and virological characteristics of dengue patients in urban Denpasar and rural Gianyar areas in Bali during the peak season in 2015. A total of 203 adult dengue-suspected patients were recruited in a prospective cross-sectional study. Demographic and clinical information were obtained, and dengue screening was performed using NS1 and IgM/IgG ELISAs...
May 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28529000/preclinical-evaluation-of-vis513-a-therapeutic-antibody-against-dengue-virus-in-non-human-primates
#2
Eugenia Z Ong, Yadunanda Budigi, Hwee Cheng Tan, Luke N Robinson, Kirk J Rowley, Alexander Winnett, Sven Hobbie, Zachary Shriver, Gregory J Babcock, Eng Eong Ooi
Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-peak viremia in NHPs neutralized infectious DENV although RNAemia remained detectable post-treatment; differential interaction of human IgGs with macaque Fc-gamma receptors may delay clearance of neutralized DENV...
May 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28528802/symptomatic-dengue-infection-during-pregnancy-and-livebirth-outcomes-in-brazil-2007-13-a-retrospective-observational-cohort-study
#3
Laura B Nascimento, Cláudio M Siqueira, Giovanini E Coelho, João B Siqueira
BACKGROUND: Dengue is a major public health challenge in Brazil. We assessed the relationship between symptomatic dengue infection during pregnancy and adverse birth outcomes in the country between 2007 and 2013. METHODS: We did a retrospective observational cohort study using information reported in the Brazilian national reportable disease information system (SINAN) and the livebirth information system (SINASC) databases. We probabilistically linked confirmed dengue-positive and dengue-negative pregnancies with live childbirths using Fine-Grained Record Integration and Linkage (FRIL) software...
May 18, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28528801/dengue-infection-during-pregnancy-and-risk-of-preterm-birth
#4
Patrícia Brasil, Otilia Lupi
No abstract text is available yet for this article.
May 18, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28528764/dengue-vaccine-safety-signal-immune-enhancement-waning-immunity-or-chance-occurrence
#5
Bradford D Gessner, Neal Halsey
A new dengue vaccine was associated with increased risk of hospitalized virologically-confirmed disease during year 3 of follow-up among children age 2-5years. Among hypotheses to explain this finding, we could not distinguish definitively between antibody dependent enhancement, waning immunity, or chance occurrence. However, any theory must account for the following: (a) the signal occurred mainly because of decreased dengue among controls rather than increased dengue among vaccinees; (b) among 48 data points, a statistically significant increase in hospitalization among vaccinated children occurred for only one age group, during one year, and in one region; (c) cumulative risk was similar for vaccinated vs...
May 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28527257/-polyclonal-antibodies-against-recombinant-dengue-virus-ns3-protein
#6
Liliana Morales, Myriam L Velandia, María Angélica Calderon, Jaime E Castellanos, Jacqueline Chaparro-Olaya
INTRODUCTION: Dengue is a disease caused by one of four serotypes of the dengue virus (DENV) and is endemic in approximately 130 countries. The incidence of dengue has increased dramatically in recent decades, as well as the frequency and magnitude of outbreaks. Despite all efforts, there are no prophylactic or therapeutic treatments for the disease. Accordingly, research on the processes governing the DENV infection cycle is essential to develop vaccines or antiviral therapies. One of themost attractive DENV molecules to investigate is nonstructural protein 3 (NS3), which is essential for viral replication and a major immune target for infection...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527246/seroprevalence-of-dengue-infection-in-the-municipalities-of-armenia-calarc%C3%A3-la-tebaida-and-montenegro-in-quind%C3%A3-o-2014
#7
Mónica Marcela Jiménez, Jesús Arias, Gabriel Carrasquilla
INTRODUCTION: Dengue is a serious public health problem in Colombia; it is prevalent in 90% of the municipalities in Quindío. Studies on its seroprevalence are required to address public health interventions. OBJECTIVE: To establish the seroprevalence of dengue infection in neighborhoods with high incidence in the municipalities of Armenia, Calarcá, La Tebaida and Montenegro, Quindío, in 2014. MATERIALS AND METHODS: We conducted a probabilistic, stratified, two-stage prevalence study...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526066/transovarial-transmission-of-denv-in-aedes-aegypti-in-the-amazon-basin-a-local-model-of-xenomonitoring
#8
Cristiano Fernandes da Costa, Ricardo Augusto Dos Passos, José Bento Pereira Lima, Rosemary Aparecida Roque, Vanderson de Souza Sampaio, Thais Bonifácio Campolina, Nágila Francinete Costa Secundino, Paulo Filemon Paolucci Pimenta
BACKGROUND: Transovarial transmission of dengue virus in Aedes spp. mosquitoes is considered an important mechanism for the maintenance of the virus in nature and may be implicated in the occurrence of outbreaks and epidemics of the disease. However, there are few studies involving transovarial transmission and viral vector monitoring as a surveillance tool and control strategy. The present study evaluated transovarial transmission of dengue virus in Aedes aegypti populations as a xenomonitoring strategy in municipalities of the Amazonas state...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#9
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28524874/impact-of-simultaneous-exposure-to-arboviruses-on-infection-and-transmission-by-aedes-aegypti-mosquitoes
#10
Claudia Rückert, James Weger-Lucarelli, Selene M Garcia-Luna, Michael C Young, Alex D Byas, Reyes A Murrieta, Joseph R Fauver, Gregory D Ebel
The recent emergence of both chikungunya and Zika viruses in the Americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one Aedes aegypti-borne virus at a time. Recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. The impact of coinfection on the ability of relevant vector species to transmit any of these viruses (that is, their vector competence) has not been determined...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28520740/ascertaining-the-impact-of-catastrophic-events-on-dengue-outbreak-the-2014-gas-explosions-in-kaohsiung-taiwan
#11
Ying-Hen Hsieh
Infectious disease outbreaks often occur in the aftermath of catastrophic events, either natural or man-made. While natural disasters such as typhoons/hurricanes, flooding and earthquakes have been known to increase the risk of infectious disease outbreak, the impact of anthropogenic disasters is less well-understood. Kaohsiung City is located in southern Taiwan, where most dengue outbreaks had occurred in the past two decades. It is also the center of petrochemical industry in Taiwan with pipelines running underneath city streets...
2017: PloS One
https://www.readbyqxmd.com/read/28520737/outdoor-spatial-spraying-against-dengue-a-false-sense-of-security-among-inhabitants-of-hermosillo-mexico
#12
Pablo A Reyes-Castro, Lucía Castro-Luque, Rolando Díaz-Caravantes, Kathleen R Walker, Mary H Hayden, Kacey C Ernst
BACKGROUND: Government-administered adulticiding is frequently conducted in response to dengue transmission worldwide. Anecdotal evidence suggests that spraying may create a "false sense of security" for residents. Our objective was to determine if there was an association between residents' reporting outdoor spatial insecticide spraying as way to prevent dengue transmission and both their reported frequency of dengue prevention practices and household entomological indices in Hermosillo, Mexico...
May 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28518476/adult-onset-chronic-cyclic-thrombocytopenia-in-a-rhesus-macaque-macaca-mulatta-after-dengue-virus-vaccination-and-viral-challenge
#13
Galit H Frydman, Kelly A Metcalf Pate, Robert P Marini, Armelle M de Laforcade, Irene Bosch, Vasudevan Bakthavatchalu, Sureshkumar Muthupalani, Alton G Swennes, Claire E Lyons, Ronald G Tompkins, James G Fox
An 8-year-old, male Rhesus macaque (Macaca mulatta), previously used for dengue virus (DENV) vaccine research with viral challenge, was presented with adult-onset, chronic, cyclic thrombocytopenia. Platelet number, morphology, and function were evaluated by automated hematology, peripheral blood smears, electron microscopy, flow cytometry, and impedance aggregometry. Bone marrow was evaluated by cytology. Both serum anti-dengue nonstructural protein 1 (NS1) antibodies and anti-platelet antibodies were detected by ELISA...
May 18, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28518022/high-frequency-of-mayaro-virus-igm-among-febrile-patients-central-brazil
#14
Sandra Brunini, Divânia Dias Silva França, Juliana Brasiel Silva, Leandro Nascimento Silva, Flúvia Pereira Amorim Silva, Mariana Spadoni, Giovanni Rezza
Mayaro virus (MAYV), an Aedes mosquito-borne alphavirus, is endemic to Brazil and other South America countries. We investigated dengue- and chikungunya-negative febrile patients visiting rural areas near Goiânia, Goiás, and found a high proportion (55%) of MAYV IgM. Our findings suggest the presence of highly endemic foci of MAYV in central Brazil.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28517033/high-throughput-sequencing-of-transposable-element-insertions-suggests-adaptive-evolution-of-the-invasive-asian-tiger-mosquito-towards-temperate-environments
#15
Clément Goubert, Hélène Henri, Guillaume Minard, Claire Valiente Moro, Patrick Mavingui, Cristina Vieira, Matthieu Boulesteix
Invasive species represent unique opportunities to evaluate the role of local adaptation during colonization of new environments. Among these species, the Asian tiger mosquito, Aedes albopictus, is a threatening vector of several human viral diseases, including dengue and chikungunya, and raises concerns about the Zika fever. Its broad presence in both temperate and tropical environments has been considered the reflection of great "ecological plasticity". However, no study has been conducted to assess the role of adaptive evolution in the ecological success of Ae...
May 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28515608/thrombotic-thrombocytopenic-purpura-in-a-case-of-dengue-fever-a-rare-presentation
#16
Abhijit S Gavali, Jayant Shelgaonkar, Sandip Bartakke
Here, we present an unusual occurrence of thrombotic thrombocytopenic purpura (TTP) in a case of dengue fever. Both the conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, as soon as, we diagnosed the patient as having TTP, we treated her with plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized...
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28515527/can-fluid-resuscitation-be-a-risk-factor-for-laryngeal-oedema-in-severe-dengue
#17
Sai Saran, Afzal Azim
No abstract text is available yet for this article.
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28515302/transposon-mutagenesis-of-the-zika-virus-genome-highlights-regions-essential-for-rna-replication-and-restricted-for-immune-evasion
#18
Benjamin O Fulton, David Sachs, Megan C Schwarz, Peter Palese, Matthew J Evans
The molecular constraints affecting Zika virus (ZIKV) evolution are not well understood. To investigate ZIKV genetic flexibility, we used transposon mutagenesis to add 15-nucleotide insertions throughout the MR766 ZIKV genome and subsequently deep sequenced the viable mutants. Few ZIKV insertion mutants replicated, which likely reflects a high degree of functional constraints on the genome. The NS1 gene exhibited distinct mutational tolerances at different stages of the screen. This result may define regions of the NS1 protein that are required for the different stages of the viral life cycle...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514683/dengue-antibodies-then-zika-a-fatal-sequence-in-mice
#19
Jonathan J Miner, Michael S Diamond
Anti-Dengue virus (DENV) antibodies can be either protective or pathogenic in humans with prior DENV infection. In a recent issue of Science, Bardina et al. (2017) demonstrated that passive transfer of immune plasma against DENV and West Nile virus (WNV) can enhance Zika virus (ZIKV) infection and pathogenesis in mice.
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28514227/real-time-evolution-of-zika-virus-disease-outbreak-roat%C3%A3-n-honduras
#20
Trevor Brooks, Arup Roy-Burman, Cascade Tuholske, Michael P Busch, Sonia Bakkour, Mars Stone, Jeffrey M Linnen, Kui Gao, Jayleen Coleman, Evan M Bloch
A Zika virus disease outbreak occurred in Roatán, Honduras, during September 2015-July 2016. Blood samples and clinical information were obtained from 183 patients given a clinical diagnosis of suspected dengue virus infection. A total of 79 patients were positive for Zika virus, 13 for chikungunya virus, and 6 for dengue virus.
August 17, 2017: Emerging Infectious Diseases
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