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https://www.readbyqxmd.com/read/28453962/a-bead-based-immunofluorescence-assay-on-a-microfluidic-dielectrophoresis-platform-for-rapid-dengue-virus-detection
#1
Edwar Iswardy, Tien-Chun Tsai, I-Fang Cheng, Tzu-Chuan Ho, Guey Chuen Perng, Hsien-Chang Chang
The proof of concept of utilizing a microfluidic dielectrophoresis (DEP) chip was conducted to rapidly detect a dengue virus (DENV) in vitro based on the fluorescence immunosensing. The mechanism of detection was that the DEP force was employed to capture the modified beads (mouse anti-flavivirus monoclonal antibody-coated beads) in the microfluidic chip and the DENV modified with fluorescence label, as the detection target, can be then captured on the modified beads by immunoreaction. The fluorescent signal was then obtained through fluorescence microscopy, and then quantified by ImageJ freeware...
April 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28453844/association-of-endothelial-glycocalyx-and-tight-and-adherens-junctions-with-severity-of-plasma-leakage-in-dengue-infection
#2
Suhendro Suwarto, R Tedjo Sasmono, Robert Sinto, Eppy Ibrahim, Maulana Suryamin
Background.: The role of vascular endothelial (VE) components in dengue infection with plasma leakage is unknown. Therefore, we conducted a study to determine the adjusted association of the endothelial glycocalyx layer (EGL) and tight and adherens junction markers with plasma leakage. Methods.: A prospective observational study was conducted at Cipto Mangunkusumo Hospital and Persahabatan Hospital, Jakarta, Indonesia. Adult dengue patients admitted to the hospital on the third day of fever from November 2013 through August 2015 were included in the study...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28449047/what-s-buzzing-on-your-feed-health-authorities-use-of-facebook-to-combat-zika-in-singapore
#3
Santosh Vijaykumar, Rianne Wally Meurzec, Karthikayen Jayasundar, Claudia Pagliari, Yohan Fernandopulle
In 2016, Singapore grappled with one of the largest Zika outbreaks in Southeast Asia. This study examines the use of Facebook for Zika-related outreach by the Ministry of Health (MOH) and the National Environmental Agency (NEA) from March 1, 2015, to September 1, 2016, and public response to this effort. Despite nearly equivalent outreach, MOH's Facebook posts received more likes (µ = 3.49) and shares (µ = 30.11), whereas NEA's posts received more comments (µ = 4.55), with NEA posting mostly on prevention (N = 30) and MOH on situational updates (N = 24)...
April 25, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28448507/detecting-the-impact-of-temperature-on-transmission-of-zika-dengue-and-chikungunya-using-mechanistic-models
#4
Erin A Mordecai, Jeremy M Cohen, Michelle V Evans, Prithvi Gudapati, Leah R Johnson, Catherine A Lippi, Kerri Miazgowicz, Courtney C Murdock, Jason R Rohr, Sadie J Ryan, Van Savage, Marta S Shocket, Anna Stewart Ibarra, Matthew B Thomas, Daniel P Weikel
Recent epidemics of Zika, dengue, and chikungunya have heightened the need to understand the seasonal and geographic range of transmission by Aedes aegypti and Ae. albopictus mosquitoes. We use mechanistic transmission models to derive predictions for how the probability and magnitude of transmission for Zika, chikungunya, and dengue change with mean temperature, and we show that these predictions are well matched by human case data. Across all three viruses, models and human case data both show that transmission occurs between 18-34°C with maximal transmission occurring in a range from 26-29°C...
April 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28448490/the-value-of-daily-platelet-counts-for-predicting-dengue-shock-syndrome-results-from-a-prospective-observational-study-of-2301-vietnamese-children-with-dengue
#5
Phung Khanh Lam, Tran Van Ngoc, Truong Thi Thu Thuy, Nguyen Thi Hong Van, Tran Thi Nhu Thuy, Dong Thi Hoai Tam, Nguyen Minh Dung, Nguyen Thi Hanh Tien, Nguyen Tan Thanh Kieu, Cameron Simmons, Bridget Wills, Marcel Wolbers
BACKGROUND: Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious complication seen in children, typically accompanied by haemoconcentration and thrombocytopenia. Robust evidence on risk factors, especially features present early in the illness course, for progression to dengue shock syndrome (DSS) is lacking...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28446670/collateral-damage-during-dengue-virus-infection-making-sense-of-dna-by-cgas
#6
Sebastian Aguirre, Ana Fernandez-Sesma
Early sensing of viral components or infection-induced tissue damage, is a prerequisite for the successful control of pathogenic viruses by the host innate immune system. Recent results from our laboratory show how immune cells use the DNA sensing machinery to detect intracellular damage generated early during infection with an RNA virus, namely dengue virus (DENV). Conversely, we found that DENV can efficiently dismantle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of interferon gene (STING); two crucial host factors involved in DNA detection and type I interferon (IFN) production...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28446607/juvenile-hormone-and-its-receptor-methoprene-tolerant-promote-ribosomal-biogenesis-and-vitellogenesis-in-the-aedes-aegypti-mosquito
#7
Jia-Lin Wang, Tusar T Saha, Yang Zhang, Changyu Zhang, Alexander S Raikhel
Juvenile hormone (JH) controls many biological activities in insects, including development, metamorphosis and reproduction. In the Aedes aegypti mosquito, a vector of Dengue, Yellow fever, Chikungunya and Zika viruses, the metabolic tissue, the fat body, which is an analogue of the vertebrate liver, produces yolk proteins (YPs) for developing oocytes. JH is important for the fat body to acquire competence for YP production. However, the molecular mechanisms of how JH promotes mosquito reproduction are not completely understood...
April 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28446573/serologic-testing-for-zika-virus-comparison-of-three-zika-virus-igm-elisas-and-initial-laboratory-experiences
#8
Dane Granger, Heather Hilgart, Lori Misner, Jaime Christensen, Sarah Bistodeau, Jennifer Palm, Anna K Strain, Marja Konstantinovski, Dakai Liu, Anthony Tran, Elitza S Theel
Serologic evaluation for Zika virus (ZIKV) infection currently includes an initial screen using an anti-ZIKV IgM antibody capture enzyme linked immunosorbent assay (MAC-ELISA) followed by supplemental testing of specimens with non-negative results by a plaque reduction neutralization test (PRNT). We compared the performance characteristics of three ELISAs for the detection of IgM-class antibodies to ZIKV, including the Centers for Disease Control and Prevention (CDC) Zika MAC-ELISA, the InBios ZIKV Detect™ MAC-ELISA, and the Euroimmun anti-Zika Virus IgM ELISA...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28444295/features-of-dengue-and-chikungunya-infections-of-colombian-children-under-24%C3%A2-months-of-age-admitted-to-the-emergency-department
#9
Angel Paternina-Caicedo, Fernando De la Hoz-Restrepo, Fredi Díaz-Quijano, William Caicedo-Torres, María Auxiliadora Badillo-Viloria, Doris Bula-Anichiarico, Nelson Alvis-Guzmán, Salim Mattar, Dagna Constenla, Hernando Pinzón-Redondo
We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis...
April 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28444003/species-abundance-and-temporal-variation-of-arbovirus-vectors-in-brownsville-texas
#10
Krithika Srinivasan, Beatriz Tapia, Arturo Rodriguez, Robert Wood, Jennifer J Salinas
The recent outbreaks of the dengue fever and West Nile viruses and the looming threats of the Zika and chikungunya viruses highlight the importance of establishing effective, proactive arboviral surveillance in communities at high risk of transmission, such as those on the Texas-Mexico border. Currently, there are no approved human vaccines available for these mosquito-borne diseases, so entomological control and case management are the only known methods for decreasing disease incidence. The principal vectors, which include Culex quinquefasciatus, Aedes aegypti, and Ae...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443981/mapping-the-dengue-scientific-landscape-worldwide-a-bibliometric-and-network-analysis
#11
Fabio Batista Mota, Bruna de Paula Fonseca E Fonseca, Andréia Cristina Galina, Roseli Monteiro da Silva
BACKGROUND: Despite the current global trend of reduction in the morbidity and mortality of neglected diseases, dengue's incidence has increased and occurrence areas have expanded. Dengue also persists as a scientific and technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics and social network analysis methods can support the mapping of dengue research and development (R&D) activities worldwide. OBJECTIVES: The aim of this paper is to map the scientific scenario related to dengue research worldwide...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28442113/temporal-patterns-of-dengue-epidemics-the-case-of-recent-outbreaks-in-kaohsiung
#12
Mattia Sanna, Ying-Hen Hsieh
OBJECTIVE: To investigate whether major dengue outbreaks in the last two decades in Kaohsiung follow a precise temporal pattern. METHODS: Government daily lab-confirmed dengue case data from three major dengue outbreaks occurring during the last two decades in Kaohsiung in 2002, 2014 and 2015, is utilized to compute the corresponding weekly cumulative percentage of total case numbers. We divide each of the three time series data into two periods to examine the corresponding weekly cumulative percentages of case numbers for each period...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28442105/towards-development-of-a-universal-dengue-vaccine-how-close-are-we
#13
REVIEW
Ee Leen Pang, Hwei-San Loh
Dengue has been ranked as one of the top emerging diseases in Asia and Latin America. Current epidemiological data may not even reflect the true burden of disease due to under-reported figures. Vector control programmes have failed to contain the disease and worst of all, no specific treatment is available at the moment. Thereby, this pushes the demand for a dengue vaccine as a long-term protective approach. Despite there are numerous vaccine candidates ahead, they could be held back by different aspects in promoting vaccine implementation...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28442104/zika-virus-infection-and-its-emerging-trends-in-southeast-asia
#14
REVIEW
Ahmad Ruzain Salehuddin, Haszianaliza Haslan, Norshalizah Mamikutty, Nurul Hannim Zaidun, Mohamad Fairuz Azmi, Mohamad Mu'izuddin Senin, Syed Baharom Syed Ahmad Fuad, Zar Chi Thent
Zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. Previously, this rare virus was limited to sporadic cases in Africa and Asia until its emergence in Brazil, South America in 2015, where it rapidly spread throughout the world. Recently, a high number of cases were reported in Singapore and other Southeast Asia countries. A combination of factors explains the current Zika virus outbreak although it is highly likely that the changes in the climate and high frequency of travelling contribute to the spread of Aedes vector carrying the Zika virus mainly to the tropical climate countries such as the Southeast Asia...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28441781/dengue-virus-non-structural-protein-5
#15
REVIEW
Abbas El Sahili, Julien Lescar
The World Health Organization estimates that the yearly number of dengue cases averages 390 million. This mosquito-borne virus disease is endemic in over 100 countries and will probably continue spreading, given the observed trend in global warming. So far, there is no antiviral drug available against dengue, but a vaccine has been recently marketed. Dengue virus also serves as a prototype for the study of other pathogenic flaviviruses that are emerging, like West Nile virus and Zika virus. Upon viral entry into the host cell and fusion of the viral lipid membrane with the endosomal membrane, the viral RNA is released and expressed as a polyprotein, that is then matured into three structural and seven non-structural (NS) proteins...
April 24, 2017: Viruses
https://www.readbyqxmd.com/read/28439894/dengue-fever-rash-white-islands-in-a-sea-of-red
#16
Ankita Srivastava
No abstract text is available yet for this article.
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28438128/viral-aetiologies-of-acute-encephalitis-in-a-hospital-based-south-asian-population
#17
Janarthani Lohitharajah, Neelika Malavige, Carukshi Arambepola, Jithangi Wanigasinghe, Ranjanie Gamage, Padma Gunaratne, Pyara Ratnayake, Thashi Chang
BACKGROUND: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population. METHODS: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28437586/pathogenesis-of-vascular-leak-in-dengue-virus-infection
#18
REVIEW
Gathsaurie Neelika Malavige, Graham S Ogg
Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular leak typically becomes clinically evident during 3-6 days since the onset of illness, which is known as the critical phase. This critical phase follows the period of peak viraemia, and lasts for 24 to 48 hours and usually shows rapid and complete reversal, suggesting it is likely to occur as a result of inflammatory mediators, rather than infection of the endothelium. Cytokines such as TNFα, which are known to be elevated in the critical phase of dengue, are likely to be contributing factors...
April 24, 2017: Immunology
https://www.readbyqxmd.com/read/28437465/serological-evidence-for-transmission-of-multiple-dengue-virus-serotypes-in-papua-new-guinea-and-west-papua-prior-to-1963
#19
Dagwin Luang-Suarkia, Timo Ernst, Michael P Alpers, Ralph Garruto, David Smith, Allison Imrie
Little is known about the natural history of dengue in Papua New Guinea (PNG). We assessed dengue virus (DENV)-specific neutralizing antibody profiles in serum samples collected from northern and southern coastal areas and the highland region of New Guinea between 1959 and 1963. Neutralizing antibodies were demonstrated in sera from the northern coast of New Guinea: from Sabron in Dutch New Guinea (now known as West Papua) and from four villages in East Sepik in what is now PNG. Previous monotypic infection with DENV-1, DENV-2, and DENV-4 was identified, with a predominance of anti-DENV-2 neutralizing antibody...
April 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28437459/management-and-outcomes-of-severe-dengue-patients-presenting-with-sepsis-in-a-tropical-country
#20
Prapit Teparrukkul, Viriya Hantrakun, Nicholas P J Day, T Eoin West, Direk Limmathurotsakul
BACKGROUND: Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management and outcomes of dengue patients presenting with sepsis in a prospective study of community-acquired sepsis in Thailand. METHODS: From June to December 2015, 874 adult patients (age≥18 years) with suspected or documented community-acquired infection, with ≥3 diagnostic criteria for sepsis according to the Surviving Sepsis Campaign 2012, and within 24 hours of admission were evaluated...
2017: PloS One
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