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https://www.readbyqxmd.com/read/29228208/advances-in-serodiagnostic-testing-for-lyme-disease-are-at-hand
#1
John A Branda, Barbara A Body, Jeff Boyle, Bernard M Branson, Raymond J Dattwyler, Erol Fikrig, Noel J Gerald, Maria Gomes-Solecki, Martin Kintrup, Michel Ledizet, Andrew E Levin, Michael Lewinski, Lance A Liotta, Adriana Marques, Paul S Mead, Emmanuel F Mongodin, Segaran Pillai, Prasad Rao, William H Robinson, Kristian M Roth, Martin E Schriefer, Thomas Slezak, Jessica Snyder, Allen C Steere, Jan Witkowski, Susan J Wong, Steven E Schutzer
The cause of Lyme disease, Borrelia burgdorferi, was discovered in 1983. A 2-tiered testing protocol was established for serodiagnosis in 1994, involving an enzyme immunoassay (EIA) or indirect fluorescence antibody, followed (if reactive) by immunoglobulin M and immunoglobulin G Western immunoblots. These assays were prepared from whole-cell cultured B. burgdorferi, lacking key in vivo expressed antigens and expressing antigens that can bind non-Borrelia antibodies. Additional drawbacks, particular to the Western immunoblot component, include low sensitivity in early infection, technical complexity, and subjective interpretation when scored by visual examination...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29228202/activity-of-ceftazidime-avibactam-against-problem-enterobacteriaceae-and-pseudomonas-aeruginosa-in-the-uk-2015-16
#2
David M Livermore, Danièle Meunier, Katie L Hopkins, Michel Doumith, Robert Hill, Rachel Pike, Peter Staves, Neil Woodford
Background: Ceftazidime/avibactam combines an established oxyimino-cephalosporin with the first diazabicyclooctane β-lactamase inhibitor to enter clinical use. We reviewed its activity against Gram-negative isolates, predominantly from the UK, referred for resistance investigation in the first year of routine testing, beginning in July 2015. Methods: Isolates were as received from referring laboratories; there is a bias to submit those with suspected carbapenem resistance...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29227906/to-disinfect-or-not-to-disinfect-in-postharvest-research-on-the-fungal-decay-of-apple
#3
Matthias Naets, Mattias van Dael, Els Vanstreels, Dirk Daelemans, Pieter Verboven, Bart Nicolaï, Wannes Keulemans, Annemie Geeraerd
Postharvest losses of fruit and vegetables can reach up to 30%, the main cause being microbial decay. For apple fruit, mostly fungal pathogens, such as Penicillium expansum, Colletotrichum spp., Neofabraea spp. and Botrytis cinerea, are important. As such losses are unsustainable in many ways, it is necessary that research is conducted to prevent them. Generally, for plants and fruit grown under non-sterile field conditions, disinfection is carried out prior to the start of a phytopathological experiment. The motivation for this practice is the removal of background contamination so that it will not affect the experimental outcome and its interpretation...
December 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29227874/selecting-passive-dosimetry-technologies-for-measuring-the-external-dose-of-terrestrial-wildlife
#4
REVIEW
Phakphum Aramrun, Nicholas A Beresford, Michael D Wood
Dosimeters attached to wild animals can be used to validate regulatory assessment approaches and models for estimating radiation exposure of wild animals. Such measurements are also necessary to ensure that robust dose-effect relationships can be developed from the results of field research programmes. This paper presents the first comprehensive evaluation of the different dosimetry technologies available for specifically measuring the external exposure of wildlife. Guidance is provided on the selection of appropriate passive dosimetry approaches for directly measuring external exposure of terrestrial wildlife under field conditions...
December 8, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29227827/determining-when-a-fracture-occurred-does-the-method-matter-analysis-of-the-similarity-of-three-different-methods-for-estimating-time-since-fracture-of-juvenile-long-bones
#5
Anne Drury, Craig Cunningham
Radiographic fracture date estimation is a critical component of skeletal trauma analysis in the living. Several timetables have been proposed for how the appearance of radiographic features can be interpreted to provide a likely time frame for fracture occurrence. This study compares three such timetables for pediatric fractures, by Islam et al. (2000), Malone et al. (2011), and Prosser et al. (2012), in order to determine whether the fracture date ranges produced by using these methods are in agreement with one another...
November 26, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29227725/interpretation-of-the-results-of-the-mindact-study-and-consequent-recommendations-in-the-updated-asco-clinical-practice-guideline
#6
Stefan Lange, Fueloep Scheibler, Daniel Fleer, Juergen Windeler
No abstract text is available yet for this article.
December 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29227658/ion-speciation-and-transport-properties-of-litfsi-in-1-3-dioxolane-solutions-a-case-study-for-li-s-battery-applications
#7
Rinaldo Raccichini, James W Dibden, Ashley Brew, John R Owen, Nuria Garcia-Araez
The Lithium-Sulfur battery is considered to be one of the main candidates for the "post-lithium-ion" battery generation, because of its high theoretical specific capacity and inherently low cost. The role of the electrolyte is particularly important in this system and remarkable battery performances have been reported by tuning the amount of salt in the electrolyte. To further understand the reasons for such improvements we chose the lithium bis(trifluoromethanesulfonyl)imide in 1,3-dioxolane electrolyte as a model salt-solvent system for a systematic study of conductivity and viscosity over a wide range of concentration from 10-5 up to 5 molal...
December 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29227524/pediatric-scoliosis-and-kyphosis-an-overview-of-diagnosis-management-and-surgical-treatment
#8
Diane Dudas Sheehan, John Grayhack
Evaluation of pediatric spinal deformity requires knowledge of special orthopaedic testing and radiographic interpretation. The determination of recommendations for treatment of spinal abnormalities in children can be challenging and at times complex, as treatment options are dependent upon a variety of factors. The etiology of scoliosis or kyphosis, presence or absence of vertebral anomalies, symptoms, magnitude of the curve, physiologic/skeletal age, and evidence of and risk of progression all require consideration and play a role in the shared decision-making process...
December 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29227445/mobile-hearing-testing-applications-and-the-diagnosis-of-sudden-sensorineural-hearing-loss-a-cautionary-tale
#9
Rosh K V Sethi, Iman Ghanad, Vivek Kanumuri, Barbara Herrmann, Elliott D Kozin, Aaron K Remenschneider
OBJECTIVE: Mobile hearing applications (apps) are available for hearing testing, personal sound amplification, as well as hearing aid modulation. Hearing testing apps are gaining popularity, especially in resource-limited settings. The reliability of mobile hearing testing apps, however, is not well characterized. PATIENTS/INTERVENTIONS: A case study of a single patient with a complaint of sudden hearing loss presenting to a tertiary-care hospital. MAIN OUTCOME MEASURE: Comparison of a mobile hearing testing app results with standard audiogram...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227369/ventilator-free-day-outcomes-can-be-misleading
#10
Laetitia Bodet-Contentin, Denis Frasca, Elsa Tavernier, Fanny Feuillet, Yohann Foucher, Bruno Giraudeau
INTRODUCTION: Acute respiratory distress syndrome often requires invasive mechanical ventilation, with both mortality and mechanical ventilation duration as outcomes of interest. The concept of ventilator-free days has been proposed as an outcome combining these two outcomes. Here we analyzed the construction of the ventilator-free day outcome and provided a hypothetical scenario to alert physicians that such an outcome can lead to misleading interpretations. METHODS: We proposed the isoventilator-free day curve concept and, using an analytical development, illustrated how a median ventilator-free day value can actually result from very different combinations of death rates and mechanical ventilation durations...
December 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29227348/quantitative-pet-ct-in-clinical-practice-assessing-the-agreement-of-pet-tumor-indices-using-different-clinical-reading-platforms
#11
Joyce C Mhlanga, Alin Chirindel, Martin A Lodge, Richard L Wahl, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to determine whether various fluorine-18-fluorodeoxyglucose PET/CT-derived parameters used in oncology vary significantly depending on the interpretation software systems used in clinical practice for multiple human solid tumors. PATIENTS AND METHODS: A total of 120 fluorine-18-fluorodeoxyglucose PET/CT studies carried out in patients with pancreatic, lung, colorectal, and head and neck cancers were evaluated retrospectively on two different vendor software platforms including Mirada and MIMVista...
December 8, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29227145/transport-induced-spatial-patterns-of-sulfur-isotopes-%C3%AE-34s-as-biosignatures
#12
Muammar Mansor, Khadouja Harouaka, Matthew S Gonzales, Jennifer L Macalady, Matthew S Fantle
Cave minerals deposited in the presence of microbes may host geochemical biosignatures that can be utilized to detect subsurface life on Earth, Mars, or other habitable worlds. The sulfur isotopic composition of gypsum (CaSO4·2H2O) formed in the presence of sulfur-oxidizing microbes in the Frasassi cave system, Italy, was evaluated as a biosignature. Sulfur isotopic compositions (δ34SV-CDT) of gypsum sampled from cave rooms with sulfidic air varied from -11 to -24‰, with minor deposits of elemental sulfur having δ34S values between -17 and -19‰...
December 11, 2017: Astrobiology
https://www.readbyqxmd.com/read/29226965/brain-reflections-a-circuit-based-framework-for-understanding-information-processing-and-cognitive-control
#13
Gabriele Gratton
Here, I propose a view of the architecture of the human information processing system, and of how it can be adapted to changing task demands (which is the hallmark of cognitive control). This view is informed by an interpretation of brain activity as reflecting the excitability level of neural representations, encoding not only stimuli and temporal contexts, but also action plans and task goals. The proposed cognitive architecture includes three types of circuits: open circuits, involved in feed-forward processing such as that connecting stimuli with responses and characterized by brief, transient brain activity; and two types of closed circuits, positive feedback circuits (characterized by sustained, high-frequency oscillatory activity), which help select and maintain representations, and negative feedback circuits (characterized by brief, low-frequency oscillatory bursts), which are instead associated with changes in representations...
December 11, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29226959/larvivorous-fish-for-preventing-malaria-transmission
#14
REVIEW
Deirdre P Walshe, Paul Garner, Ahmed A Adeel, Graham H Pyke, Thomas R Burkot
BACKGROUND: Adult female Anopheles mosquitoes can transmit Plasmodium parasites that cause malaria. Some fish species eat mosquito larvae and pupae. In disease control policy documents, the World Health Organization (WHO) includes biological control of malaria vectors by stocking ponds, rivers, and water collections near where people live with larvivorous fish to reduce Plasmodium parasite transmission. In the past, the Global Fund has financed larvivorous fish programmes in some countries, and, with increasing efforts in eradication of malaria, policymakers may return to this option...
December 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29226871/increased-serum-acylated-ghrelin-levels-in%C3%A2-patients-with-mild-cognitive-impairment
#15
Xi Cao, Min Zhu, Yan He, Wenzheng Chu, Yifeng Du, Heng Du
Ghrelin is a stomach-derived circulating hormone. In addition to its function as an orexigenic stimulant, the role of ghrelin in the consolidation of learning and memory has been implicated in recent years. However, the status of circulating acylated ghrelin (AG, that is, the functional form of ghrelin) in the symptomatic predementia stage of Alzheimer's disease (AD) has rarely been investigated. In the current study, we examined the serum levels of acylated and total ghrelin in 22 patients with mild cognitive impairment (MCI) and 30 cognitively normal controls...
December 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226850/temperature-dependent-infrared-nano-imaging-of-la0-67sr0-33mno3-thin-film
#16
Peng Xu, T J Huffman, In Hae Kwak, Amlan Biswas, M M Qazilbash
We investigate the temperature dependence of infrared properties at nanometer length scales in La0.67Sr0.33MnO3 (LSMO) thin film with a thickness of 47 unit cells grown on SrTiO3 substrate. The infrared nano-imaging experiments were performed using a near-field optical microscope in conjunction with a variable temperature heating stage. The near-field infrared data is consistent with the bulk of the LSMO film undergoing the thermally-driven non-percolative second-order transition from a metallic, ferromagnetic phase to an insulating, paramagnetic phase...
December 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29226826/prostate-magnetic-resonance-imaging-interpretation-varies-substantially-across-radiologists
#17
Geoffrey A Sonn, Richard E Fan, Pejman Ghanouni, Nancy N Wang, James D Brooks, Andreas M Loening, Bruce L Daniel, Katherine J To'o, Alan E Thong, John T Leppert
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists of varying expertise has not been verified. OBJECTIVE: To assess variability in mpMRI reporting and diagnostic accuracy across radiologists of varying experience in routine clinical care. DESIGN, SETTING, AND PARTICIPANTS: Men who underwent mpMRI and MR-fusion biopsy between 2014-2016...
December 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29226810/standardisation-of-lung-function-test-interpretation-global-lung-function-initiative
#18
Sanja Stanojevic
No abstract text is available yet for this article.
December 6, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29226799/evaluation-of-a-school-based-cognitive-behavioral-depression-prevention-program
#19
Pernilla Garmy, Eva K Clausson, Agneta Berg, Katarina Steen Carlsson, Ulf Jakobsson
AIM: The aim of this study was to investigate the feasibility and cost-utility of a school-based cognitive-behavioral (CB) depression prevention program. METHODS: A quasi-experimental trial with an intervention group and a control group, with follow-up measurements obtained at three and 12 months after baseline, was conducted. The setting was six Swedish municipalities. The participants were students in grade 8 (median age: 14). A total of 462 students (79% girls) were allocated to the school-based CB prevention program, and 486 students (46% girls) were allocated to the control group...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29226759/evaluation-and-interpretation-of-the-bucket-test-in-healthy-individuals
#20
Erika Celis-Aguilar, Angel Castro-Urquizo, Juan Mariscal-Castro
OBJECTIVE: To determine and interpret the range of normal deviation of the bucket test in healthy subjects Subjects and methods: Study design: Cross-sectional study in a secondary care center. INCLUSION CRITERIA: subjects ≥18 years old with no otologic or neurologic symptoms and normal complete neuro-otological examination. The subjective visual vertical was evaluated binocularly using the bucket test. Five measurements were made on the clockwise direction and five on the counterclockwise direction...
December 9, 2017: Acta Oto-laryngologica
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