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Pulsed electromagnetic field

James S Gaynor, Sean Hagberg, Blake T Gurfein
Pulsed electromagnetic field (PEMF) therapy can non-invasively treat a variety of pathologies by delivering electric and magnetic fields to tissues via inductive coils. The electromagnetic fields generated by these devices have been found to affect a variety of biological processes and basic science understanding of the underlying mechanisms of action of PEMF treatment has accelerated in the last 10 years. Accumulating clinical evidence supports the use of PEMF therapy in both animals and humans for specific clinical indications including bone healing, wound healing, osteoarthritis and inflammation, and treatment of post-operative pain and edema...
May 7, 2018: Research in Veterinary Science
Yukun Yin, Ping Chen, Qiang Yu, Yan Peng, ZeHao Zhu, Jing Tian
BACKGROUND A low frequency pulsed electromagnetic field (PEMF) has been confirmed to play an important role in promoting the osteogenic differentiation of human bone marrow stem cells (BMSCs). Adipose-derived stem cells (ASCs) possess some attractive characteristics for clinical application compared to BMSCs, such as abundant stem cells from lipoaspirates, faster growth, less discomfort and morbidity during surgery. ASCs can become adipocytes, osteoblasts, chondrocytes, myocytes, neurocytes, and other cell types...
May 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
F Niel, C Riconda, F Amiranoff, R Duclous, M Grech
Radiation reaction in the interaction of ultrarelativistic electrons with a strong external electromagnetic field is investigated using a kinetic approach in the nonlinear moderately quantum regime. Three complementary descriptions are discussed considering arbitrary geometries of interaction: a deterministic one relying on the quantum-corrected radiation reaction force in the Landau and Lifschitz (LL) form, a linear Boltzmann equation for the electron distribution function, and a Fokker-Planck (FP) expansion in the limit where the emitted photon energies are small with respect to that of the emitting electrons...
April 2018: Physical Review. E
A Hochsprung, S Escudero-Uribe, A J Ibáñez-Vera, G Izquierdo-Ayuso
INTRODUCTION: Pain is highly prevalent in patients with multiple sclerosis (MS); it is chronic in 50% of cases and is classified as nociceptive, neuropathic, or mixed-type. Pain affects quality of life, sleep, and the activities of daily living. Electrotherapy is an interesting alternative or complementary treatment in the management of pain in MS, with new innovations constantly appearing. MATERIAL AND METHODS: This study evaluates the effectiveness of treatment with monopolar dielectric transmission of pulsed electromagnetic fields (PEMF) for pain associated with MS...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Yutian Lei, Jinyu Su, Haixia Xu, Qiang Yu, Ming Zhao, Jing Tian
When bone resorption, aided by the activity of osteoclasts, exceeds bone formation induced by osteoblasts, bone metabolism loses equilibration, which results in the development of bone diseases, including osteoporosis. Pulsed electromagnetic fields (PEMFs) are known to be involved in various biological processes, including cell proliferation, differentiation and apoptosis. However, the exact mechanism of action of osteoclasts remains poorly understood. In the present study, the effects of PEMFs on osteoclast differentiation and associated signaling pathways were systematically investigated in RAW264...
May 9, 2018: Molecular Medicine Reports
Lutful Ahad, Jari Turunen, Ari T Friberg, Tero Setälä
We present a novel time-domain coherent-mode representation for random, stationary electromagnetic beams. We subsequently introduce random, quasistationary pulsed electromagnetic beams and develop an analogous (pseudo) mode decomposition for them as well. The former decomposition is valid provided the time window in which the field is considered is much longer than the coherence time, while the latter requires the field to vanish outside the window. For stationary beams, the theory is demonstrated by an example illustrating the role of polarization in the representation...
May 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Tomoaki Ishii, Hiromichi Yamakawa, Toshiki Kanaki, Tatsuya Miyamoto, Noriaki Kida, Hiroshi Okamoto, Masaaki Tanaka, Shinobu Ohya
High-speed magnetization control of ferromagnetic films using light pulses is attracting considerable attention and is increasingly important for the development of spintronic devices. Irradiation with a nearly monocyclic terahertz pulse, which can induce strong electromagnetic fields in ferromagnetic films within an extremely short time of less than ~1 ps, is promising for damping-free high-speed coherent control of the magnetization. Here, we successfully observe a terahertz response in a ferromagnetic-semiconductor thin film...
May 2, 2018: Scientific Reports
Rui Li, Yongdong Li, Jiancang Su, Binxiong Yu, Xiudong Xu, Liang Zhao, Jie Cheng, Bo Zeng
A coaxial-output capacitor-loaded annular pulse forming line (PFL) is developed in order to reduce the flat top fluctuation amplitude of the forming quasi-square pulse and improve the quality of the pulse waveform produced by a Tesla-pulse forming network (PFN) type pulse generator. A single module composed of three involute dual-plate PFNs is designed, with a characteristic impedance of 2.44 Ω, an electrical length of 15 ns, and a sustaining voltage of 60 kV. The three involute dual-plate PFNs connected in parallel have the same impedance and electrical length...
April 2018: Review of Scientific Instruments
Z Balevicius, R Lescinskas, R Celiesiute, A Stirke, S Balevicius, S Kersulis, V Bleizgys, R Maciuleviciene, A Ramanavicius, N Zurauskiene
The compact potentiometer, based on an electronic circuit protected from electrostatic and electromagnetic interference, was developed for the measurement of low ion concentrations in liquids. The electronic circuit of the potentiometer, consisting of analogous and digital parts, enables the measurement of fA currents. This makes it possible to perform reliable measurements of ion concentrations in liquids that are as small as 10-8 -10-7 M. The instrument was tested using electrodes that were selective for tetraphenylphosphonium (TPP+ ) ions...
April 2018: Review of Scientific Instruments
Neža Prezelj, Maja Trošt, Dejan Georgiev, Dušan Flisar
Deep brain stimulation (DBS) is an established treatment option for advanced stages of Parkinson's disease and other movement disorders. It is known that DBS is susceptible to strong electromagnetic fields (EMFs) that can be generated by various electrical devices at work, home, and in medical environments. EMFs can interfere with the proper functioning of implantable pulse generators (IPGs). Very strong EMFs can generate induction currents in implanted electrodes and even damage the brain. Manufacturers of DBS devices have issued a list of warnings on how to avoid this danger...
May 1, 2018: Journal of Neurosurgery
Juhani Multanen, Arja Häkkinen, Pauli Heikkinen, Hannu Kautiainen, Sirpa Mustalampi, Jari Ylinen
Low-energy pulsed electromagnetic field (PEMF) therapy has been suggested as a promising therapy to increase microcirculation, which is of great concern in patients with fibromyalgia. This study evaluated the effectiveness of PEMF therapy on the treatment of fibromyalgia. A group of 108 women with fibromyalgia were allocated to a 12-week treatment period with an active Bio-Electro-Magnetic-Energy-Regulation (BEMER) device and a similar treatment period with an inactive device. Each patient received active and sham treatments in a random order...
April 30, 2018: Bioelectromagnetics
Tímea Téglás, Gabriella Dörnyei, Károly Bretz, Csaba Nyakas
During advanced aging passive exercise (PE) is becoming a valuable therapeutic intervention to improve physical and mental performances. In the present study chronic low frequency pulsed electromagnetic field (EMF) exposure was presented to senescent rats in order to clarify the behavioural effects related to cognitive and motility functions. Male Wistar rats of 30-32 months old were treated with EMF for six weeks, 3 times per week, 24 min per sessions prior to the age of 32 months. Stimulation intensities varied from 45 to 1250 µT...
April 24, 2018: Behavioural Brain Research
Jie Yuan, Fei Xin, Wenxue Jiang
Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe physical therapy strategy to accelerate bone repair has received tremendous attention in recent decades. Physical PEMF stimulation initiates the signaling cascades, which effectively promote osteogenesis and angiogenesis in an orchestrated spatiotemporal manner and ultimately enhance the self-repair capability of bone tissues. Considerable research progresses have been made in exploring the underlying cellular and subcellular mechanisms of PEMF promotion effect in bone repair...
April 20, 2018: Cellular Physiology and Biochemistry
Ofer Neufeld, Oren Cohen
Optical chirality (OC)-one of the fundamental quantities of electromagnetic fields-corresponds to the instantaneous chirality of light. It has been utilized for exploring chiral light-matter interactions in linear optics, but has not yet been applied to nonlinear processes. Motivated to explore the role of OC in the generation of helically polarized high-order harmonics and attosecond pulses, we first separate the OC of transversal and paraxial beams to polarization and orbital terms. We find that the polarization-associated OC of attosecond pulses corresponds approximately to that of the pump in the quasimonochromatic case, but not in the multichromatic pump cases...
March 30, 2018: Physical Review Letters
Faith J Scott, Erika L Sesti, Eric J Choi, Alexander J Laut, Jagadishwar R Sirigiri, Alexander B Barnes
We introduce a novel design for millimeter wave electromagnetic structures within magic angle spinning (MAS) rotors. In this demonstration, a copper coating is vacuum deposited onto the outside surface of a sapphire rotor at a thickness of 50 nanometers. This thickness is sufficient to reflect 197 GHz microwaves, yet not too thick as to interfere with radiofrequency fields at 300 MHz or prevent sample spinning due to eddy currents. Electromagnetic simulations of an idealized rotor geometry show a microwave quality factor of 148...
April 19, 2018: Magnetic Resonance in Chemistry: MRC
Baoying Zhu, Jian Zhou, Yuhai Gao, Wengui Shi, Zhenlong Wei, Wenyuan Li, Yuanyuan Wang, Keming Chen
<b>Objective:</b> To compare the effects of 50 Hz 1.8 mT sinusoidal magnetic field (SEMF) and 50 Hz 0.6 mT pulsed electromagnetic field(PEMF) on the maturation and mineralization of rat calvaria osteoblasts. <b>Methods:</b> Primary cultured rat calvarial osteoblasts were divided into 3 groups:blank control group, SEMF group and PEMF group. The rats in SEMT and PEMT groups were treated with 50 Hz 1.8 mT SEMF or 50 Hz 0.6 mT PEMF for 90 min/d, respectively. Western blotting and Real-time RT-PCR were used to detect the protein and mRNA expressions of Collagen-1, bone morphogenetic protein 2 (BMP-2), osterix (OSX) and Runt-associated transcription factor 2(Runx-2)...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Vitalij Novickij, Auksė Zinkevičienė, Justinas Valiulis, Jurgita Švedienė, Algimantas Paškevičius, Eglė Lastauskienė, Svetlana Markovskaja, Jurij Novickij, Irutė Girkontaitė
Genetic manipulation of T cells is frequently inefficient, however, when combined with physical methods (i.e. electroporation) a promising alliance with immunotherapy can be formed. This study presents new data on permeabilization of murine thymocytes and splenocytes as a T cell model using pulsed electric (PEF) and electromagnetic field (EMF). The 300ns, 500ns, 2μs and 100μs pulse bursts in a broad range of PEF 0-8kV/cm were applied separately and in combination with 3.3T, 0.2kV/cm EMF pulses. The permeabilization efficiency was evaluated using fluorescent dye (YO-PRO-1) and flow cytometry...
April 10, 2018: Bioelectrochemistry
Jennifer Frankel, Jonna Wilén, Kjell Hansson Mild
A complex mixture of electromagnetic fields is used in magnetic resonance imaging (MRI): static, low-frequency, and radio frequency magnetic fields. Commonly, the static magnetic field ranges from one to three Tesla. The low-frequency field can reach several millitesla and with a time derivative of the order of some Tesla per second. The radiofrequency (RF) field has a magnitude in the microtesla range giving rise to specific absorption rate values of a few Watts per kilogram. Very little attention has been paid to the case where there is a combined exposure to several different fields at the same time...
2018: Frontiers in Public Health
Martina Nardoni, Elena Della Valle, Micaela Liberti, Michela Relucenti, Maria Antonietta Casadei, Patrizia Paolicelli, Francesca Apollonio, Stefania Petralito
Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability. This result can be effectively achieved with low intensity non-thermal alternating magnetic field (AMF), which, however, found rare clinic application. Therefore, a different modality of generating non-thermal magnetic fields has now been investigated. Specifically, the ability of the intermittent signals generated by non-thermal pulsed electromagnetic fields (PEMFS) were used to verify if, once applied to high-transition temperature magnetoliposomes (high-Tm MLs), they could be able to efficiently trigger the release of a hydrophilic model drug...
March 27, 2018: Nanomaterials
Sabrina Ehnert, Martijn van Griensven, Marina Unger, Hanna Scheffler, Karsten Falldorf, Anne-Kristin Fentz, Claudine Seeliger, Steffen Schröter, Andreas K Nussler, Elizabeth R Balmayor
Human adipose-derived mesenchymal stem cells (Ad-MSCs) have been proposed as suitable option for cell-based therapies to support bone regeneration. In the bone environment, Ad-MSCs will receive stimuli from resident cells that may favor their osteogenic differentiation. There is recent evidence that this process can be further improved by extremely low frequency pulsed electromagnetic fields (ELF-PEMFs). Thus, the project aimed at (i) investigating whether co-culture conditions of human osteoblasts (OBs) and Ad-MSCs have an impact on their proliferation and osteogenic differentiation; (ii) whether this effect can be further improved by repetitive exposure to two specific ELF-PEMFs (16 and 26 Hz); (iii) and the effect of these ELF-PEMFs on human osteoclasts (OCs)...
March 27, 2018: International Journal of Molecular Sciences
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