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cow milk and cancer

D P Mohanty, S Mohapatra, S Misra, P S Sahu
Milk-derived bioactive peptides have been identified as potential ingredients of health-promoting functional foods. These bioactive peptides are targeted at diet-related chronic diseases especially the non-communicable diseases viz., obesity, cardiovascular diseases and diabetes. Peptides derived from the milk of cow, goat, sheep, buffalo and camel exert multifunctional properties, including anti-microbial, immune modulatory, anti-oxidant, inhibitory effect on enzymes, anti-thrombotic, and antagonistic activities against various toxic agents...
September 2016: Saudi Journal of Biological Sciences
Xiaoming Hou, Hongliu Hu, Ye Lin, Bo Qu, Xuejun Gao, Qingzhang Li
Milk protein is an important component of milk and a nutritional source for human consumption. To better understand the molecular events underlying synthesis of milk proteins, the global gene expression patterns in mammary glands of dairy cow with high-quality milk (>3% milk protein; >3.5% milk fat) and low-quality milk (<3% milk protein; <3.5% milk fat) were examined via digital gene expression study. A total of 139 upregulated and 66 downregulated genes were detected in the mammary tissues of lactating cows with high-quality milk compared with the tissues of cows with low-quality milk...
July 2016: Journal of Dairy Science
Hector R Galván-Salazar, Alejandro Arreola-Cruz, Daniela Madrigal-Pérez, Alejandro D Soriano-Hernández, Jose Guzman-Esquivel, Daniel A Montes-Galindo, Rodrigo A López-Flores, Francisco Espinoza-Gomez, Iram P Rodríguez-Sanchez, Oscar A Newton-Sanchez, Agustin Lara-Esqueda, Margarita L Martinez-Fierro, Xochitl G Briseño-Gomez, Ivan Delgado-Enciso
BACKGROUND: Breast cancer is a public health problem and it is the most common gynecologic neoplasia worldwide. The risk factors for its development are of both hereditary and environmental origin. Certain foods have been clearly associated with modifying the breast cancer risk. The aim of the present analysis was to evaluate the effects of cow's milk and meat consumption on the development of breast cancer in a population from Western Mexico (Colima). MATERIAL AND METHODS: We studied 97 patients presenting with a histopathologic diagnosis of breast cancer and 104 control individuals who did not present with the disease (Breast Imaging Report and Data System (BI-RADS) 1-2)...
December 2015: Breast Care
Bodo C Melnik
Single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity-associated) gene are associated with enhanced FTO expression, increased body weight, obesity and type 2 diabetes mellitus (T2DM). The N (6) -methyladenosine (m(6)A) demethylase FTO plays a pivotal regulatory role for postnatal growth and energy expenditure. The purpose of this review is to provide translational evidence that links milk signaling with FTO-activated transcription of the milk recipient. FTO-dependent demethylation of m(6)A regulates mRNA splicing required for adipogenesis, increases the stability of mRNAs, and affects microRNA (miRNA) expression and miRNA biosynthesis...
2015: Journal of Translational Medicine
J A Otero, V Miguel, L González-Lobato, R García-Villalba, J C Espín, J G Prieto, G Merino, A I Álvarez
The ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP) is an efflux protein involved in the bioavailability and milk secretion of endogenous and exogenous compounds, actively affecting milk composition. A limited number of physiological substrates have been identified. However, no studies have reported the specific effect of this polymorphism on the secretion into milk of compounds implicated in milk quality such as vitamins or endogenous compounds. The bovine ABCG2 Y581S polymorphism is described as a gain-of-function polymorphism that increases milk secretion and decreases plasma levels of its substrates...
February 2016: Animal: An International Journal of Animal Bioscience
Alireza Farsad-Naeimi, Saeid Imani, Seyed R Arefhosseini, Mohammad Alizadeh
BACKGROUND: Conjugated linoleic acid (CLA) is a special fatty acid in dairy products with unique antioxidant and anti-cancerous effects. Kefir, a milk product, comprises normalized homogenized cow's milk, the fructose and lactulose syrup as well as a symbiotic starter which has improved probiotic characteristics. The study was aimed to discuss patents and to examine the effect of different safflower oil concentrations on CLA content of the kefir drink prepared by low-fat milk. MATERIAL AND METHODS: Safflower oil was added at 0...
2015: Recent Patents on Food, Nutrition & Agriculture
Hassan Malekinejad, Aysa Rezabakhsh
BACKGROUND: The presence of hormones in milk and dairy foods was discussed decades ago but rather more concerns attended to that with respect to finding hormones as biomarkers in milk for diseases and pregnancy diagnosis. Moreover, considerable amount of studies demonstrated that existing of hormones in humans and animals milk are essential for infants growing and immunity. During the last couple of years, increasing body of evidence are indicating another property of hormones in dairy products as possible impact on human health including the role of some estrogens and insulin-like growth factor-1 in initiation and provoking of breast, prostate and endometrial tumours...
June 2015: Iranian Journal of Public Health
Bodo C Melnik
Based on own translational research of the biochemical and hormonal effects of cow's milk consumption in humans, this review presents milk as a signaling system of mammalian evolution that activates the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the pivotal regulator of translation. Milk, a mammary gland-derived secretory product, is required for species-specific gene-nutrient interactions that promote appropriate growth and development of the newborn mammal. This signaling system is highly conserved and tightly controlled by the lactation genome...
2015: International Journal of Molecular Sciences
Alfredo Mazza, Prisco Piscitelli, Cosimo Neglia, Giulia Della Rosa, Leopoldo Iannuzzi
The region of Campania (particularly Naples and Caserta) has experienced an emergency in the waste management cycle during past years. Although the most critical phase has been overcome after the construction of the incineration plant in Acerra (an old-fashioned technology built up over a few months, whose impact on environment and health has not yet been assessed), most of the underlying problems have not been resolved. The illegal burning of wheels, plastics, textiles, and other industrial residuals, along with the detection of two thousand toxic substance dumping sites, still represents major concerns of environmental pollution and population health...
June 2015: International Journal of Environmental Research and Public Health
Harald zur Hausen, Ethel-Michele de Villiers
The analysis of published epidemiological data on colon and breast cancer reveals a remarkable concordance for most regions of the world. A low incidence for both cancers has been recorded in Mongolia and Bolivia. Discrepant data, however, have been reported for India, Japan and Korea. In India, the incidence of breast cancer is significantly higher than for colon cancer, in Japan and Korea colon cancer exceeds by far the rate of breast cancer. Here, studies are summarized pointing to a species-specific risk for colon cancer after consumption of beef originating from dairy cattle...
August 15, 2015: International Journal of Cancer. Journal International du Cancer
Bodo C Melnik, Swen Malte John, Gerd Schmitz
Antenatal dietary lifestyle intervention and nutrition during pregnancy and early postnatal life are important for appropriate lifelong metabolic programming. Epidemiological evidence underlines the crucial role of increased birth weight as a risk factor for the development of chronic diseases of civilization such as obesity, diabetes and cancer. Obstetricians and general practitioners usually recommend milk consumption during pregnancy as a nutrient enriched in valuable proteins and calcium for bone growth...
2015: Journal of Translational Medicine
Elena Fernández Fernández, José Alfredo Martínez Hernández, Venancio Martínez Suárez, José Manuel Moreno Villares, Luis Rodolfo Collado Yurrita, Marta Hernández Cabria, Francisco Javier Morán Rey
Cow's milk is a staple food for human consumption at all stages of life. Industrial processing has allowed widespread access to its consumption by the population, which has helped to significantly improve their health. From its composition point of view, milk is a complete and balanced food that provides high nutrient content in relation to its calorie content, so its consumption should be considered necessary from childhood to elderly. The benefits of cow's milk are not limited to its nutritional value, but extend beyond and are a factor of prevention in certain non communicable pathologies as cardiovascular disease, some cancers, high blood pressure or bone or dental pathology...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ioannis N Tsakiris, Marina Goumenou, Manolis N Tzatzarakis, Athanasios K Alegakis, Christina Tsitsimpikou, Eren Ozcagli, Dionysios Vynias, Aristidis M Tsatsakis
The occurrence of residues of DDT and its metabolites was monitored in 196 cow milk samples of various pasteurized commercial types collected from the Greek market. Residue levels were determined by GC-MS analysis. In 97.4% of the samples at least one DDT isomer or one of the DDT metabolites was detected, in levels not exceeding the maximum permitted residue level by the EU. Hazard Index for both carcinogenic and non-carcinogenic effects was estimated under two assumptions: a) using DDT concentrations from positive samples and b) imputing LOD/2 as an arbitrary concentration for negative samples...
January 2015: Food and Chemical Toxicology
Georg Alfthan, Merja Eurola, Päivi Ekholm, Eija-Riitta Venäläinen, Tarja Root, Katja Korkalainen, Helinä Hartikainen, Pirjo Salminen, Veli Hietaniemi, Pentti Aspila, Antti Aro
Despite different geological features the Nordic countries are generally selenium-poor areas. In each country various factors such as food importation and life-style determine the selenium (Se) intake. Due to an extremely low Se intake in the 1970s in Finland, 0.025 mg/day, an official decision was made in 1984 to supplement multinutrient fertilizers with Se in the chemical form of sodium selenate. Almost all fertilizers used in Finland since 1985 have contained Se. Currently all crop fertilizers contain 15 mg Se/kg...
2015: Journal of Trace Elements in Medicine and Biology
Paula C Pereira
Dairy and milk consumption are frequently included as important elements in a healthy and balanced diet. It is the first food for mammals and provides all the necessary energy and nutrients to ensure proper growth and development, being crucial in respect to bone mass formation. However, several controversies arise from consumption of dairy and milk products during adulthood, especially because it refers to milk from other species. Despite these controversies, epidemiologic studies confirm the nutritional importance of milk in the human diet and reinforce the possible role of its consumption in preventing several chronic conditions like cardiovascular diseases (CVDs), some forms of cancer, obesity, and diabetes...
June 2014: Nutrition
Dorota Najgebauer-Lejko, Tadeusz Grega, Małgorzata Tabaszewska
BACKGROUND: Yoghurt is a fermented milk of unique sensory, nutritive and dietetic value offered in a variety of types and in different flavours. Vegetables belong to the group of food products rich in antioxidant substances (e.g., vitamin C, carotenoids, tocopherols, polyphenols) which regular consumption lowers the risk of many diseases including cancers and cardiovascular disorders. The aim of the present work was to manufacture and assess the acidity, sensory quality and antioxidant capacity of yoghurts with addition of selected vegetables during 2-week refrigerated storage...
January 2014: Acta Scientiarum Polonorum. Technologia Alimentaria
R W Armstrong
In 1988 a follow-up investigation was made of a case-control study conducted in 1962 in Iceland which tested hypotheses that trace elements in pasture grass, drinking water and cow's milk were associated through diet with cancer of the stomach. Samples were collected in 1962 from 26 farms in the northern county of Skagafjardarsysla and 30 farms in the southern county of Rangarvallasysla. The main objective of the present study was to establish the cancer experience of the 297 residents of the 56 farms since 1962...
September 1990: Environmental Geochemistry and Health
Jenny M Warrington, Julie J M Kim, Priska Stahel, Scott R L Cieslar, Roger A Moorehead, Brenda L Coomber, Milena Corredig, John P Cant
BACKGROUND: Dietary selenium has the potential to reduce growth of mammary tumors. Increasing the Se content of cows' milk proteins is a potentially effective means to increase Se intake in humans. We investigate the effects of selenized milk protein on human mammary tumor progression in immunodeficient BALB/c nude mice. METHODS: Four isonitrogenous diets with selenium levels of 0.16, 0.51, 0.85 and 1.15 ppm were formulated by mixing low- and high-selenium milk casein isolates with a rodent premix...
2013: BMC Cancer
Dominique Turck
Cow's milk is increasingly suggested to play a role in the development of chronic degenerative, non-communicable disorders whereas goat's milk is advocated as having several health benefits. Cow's milk is a rich and cheap source of protein and calcium, and a valuable food for bone health. Despite their high content in saturated fats, consumption of full-fat dairy products does not seem to cause significant changes in cardiovascular disease risk variables. Early introduction of cow's milk is a strong negative determinant of iron status...
2013: World Review of Nutrition and Dietetics
Jolanta Artym, Michał Zimecki
Clinical trials are reviewed, involving proteins and peptides derived from milk (predominantly bovine), with the exception of lactoferrin, which will be the subject of another article. The most explored milk fraction is α-lactalbumin (LA), which is often applied with glycomacropeptide (GMP) - a casein degradation product. These milk constituents are used in health-promoting infant and adult formulae as well as in a modified form (HAMLET) to treat cancer. Lactoperoxidase (LCP) is used as an additive to mouth hygiene products and as a salivary substitute...
2013: Postȩpy Higieny i Medycyny Doświadczalnej
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