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https://www.readbyqxmd.com/read/29452372/impact-of-timing-of-influenza-vaccination-in-pregnancy-on-transplacental-antibody-transfer-influenza-incidence-and-birth-outcomes-a-randomized-trial-in-rural-nepal
#1
Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, James M Tielsch
Background: Maternal influenza vaccination protects mothers and their infants in low resource settings but little is known about whether the protection varies by gestational age at vaccination. Methods: Women of childbearing age in rural southern Nepal were surveilled for pregnancy, consented and randomized to receive maternal influenza vaccination or placebo, with randomization stratified on gestational age (17-25 or 26-34 weeks). Enrollment occurred in two annual cohorts and vaccinations occurred from April 2011 through September 2013...
February 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29450884/is-sonographically-measured-cervical-length-at-37-weeks-gestation-associated-with-intrapartum-cesarean-section-a-prospective-cohort-study
#2
Bradley de Vries, Rajit Narayan, Kevin McGeechan, Stanley Santiagu, Ramesh Vairavan, Minke Burke, Hala Phipps, Jon Hyett
Cesarean section rates continue to increase globally. Prediction of intrapartum cesarean section could lead to preventative measures. Our aim was to assess the association between sonographically measured cervical length at 37 weeks' gestation and cesarean section among women planning a vaginal birth. The population was women with a low risk pregnancy or with gestational diabetes MATERIAL AND METHODS: This was a prospective cohort study conducted in a tertiary referral hospital in Sydney, Australia. 212 women with a low risk pregnancy or with gestational diabetes were recruited including 158 nulliparous and 54 parous women...
February 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29447147/assisted-reproductive-technology-surveillance-united-states-2015
#3
Saswati Sunderam, Dmitry M Kissin, Sara B Crawford, Suzanne G Folger, Sheree L Boulet, Lee Warner, Wanda D Barfield
PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which eggs or embryos are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Although the majority of infants conceived through ART are singletons, women who undergo ART procedures are more likely than women who conceive naturally to deliver multiple-birth infants...
February 16, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29438637/population-attributable-fractions-of-perinatal-outcomes-for-nulliparous-women-associated-with-overweight-and-obesity-1990-2014
#4
Kate Cheney, Rachel Farber, Alexandra L Barratt, Kevin McGeechan, Bradley de Vries, Robert Ogle, Kirsten I Black
OBJECTIVE: To examine the prevalence across 25 years of overweight and obesity among nulliparous Australian women during early pregnancy; to estimate the proportions of adverse perinatal outcomes attributable to overweight and obesity in this population. DESIGN: Cohort study; retrospective analysis of electronic maternity data. Setting, participants: 42 582 nulliparous women with singleton pregnancies giving birth at the Royal Prince Alfred Hospital, an urban teaching hospital in Sydney, January 1990 - December 2014...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29433666/similarities-and-differences-in-child-development-from-birth-to-age-3-years-by-sex-and-across-four-countries-a-cross-sectional-observational-study
#5
Ilgi Ozturk Ertem, Vibha Krishnamurthy, Mphelekedzeni C Mulaudzi, Yanina Sguassero, Hakan Balta, Ozlem Gulumser, Burcu Bilik, Roopa Srinivasan, Benjamin Johnson, Geliang Gan, Lisa Calvocoressi, Veronika Shabanova, Brian W C Forsyth
BACKGROUND: Knowledge about typical development is of fundamental importance for understanding and promoting child health and development. We aimed to ascertain when healthy children in four culturally and linguistically different countries attain developmental milestones and to identify similarities and differences across sexes and countries. METHODS: In this cross-sectional, observational study, we recruited children aged 0-42 months and their caregivers between March 3, 2011, and May 18, 2015, at 22 health clinics in Argentina, India, South Africa, and Turkey...
March 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29432888/audit-of-cardiac-surgery-outcomes-for-low-birth-weight-and-premature-infants
#6
Peter Alarcon Manchego, Michael Cheung, Diana Zanino, Russell Nunn, Yves D'Udekem, Christian Brizard
OBJECTIVE: The burden of disease associated with cardiac surgery in preterm and low birth weight infants is increasing. This retrospective study aimed to compare the mortality and morbidity of cardiac surgery in low birth weight and preterm infants with that of a case-matched normal population. METHODS: This was a single-centre audit of cardiac surgery interventions at a tertiary paediatric centre in Melbourne, Australia. Subjects underwent intervention in the first three months of life and were preterm (< 37 weeks gestation) and/or <2,500 grams at birth...
February 9, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29427091/current-clinical-and-bacteriological-profile-of-septic-arthritis-in-young-infants-a-prospective-study-from-a-tertiary-referral-centre
#7
Gireesh Sankaran, Balaji Zacharia, Antony Roy, Sulaikha Puthan Purayil
PURPOSE: The study was carried out to evaluate the clinical and bacteriological profile of SA in young infants (age ≤ 3 months) in a tertiary referral centre and to assess the risk factors and to document the changing trends in the epidemiology. METHODS: This was a prospective descriptive study on all young infants with SA. Clinical and perinatal history, examination, radiological and laboratory findings (blood count, ESR, CRP, blood and joint cultures) were studied...
February 9, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29422215/long-term-cardiovascular-consequences-of-fetal-growth-restriction-biology-clinical-implications-and-opportunities-for-prevention-of-adult-disease
#8
REVIEW
Fatima Crispi, Jezid Miranda, Eduard Gratacós
In the modern world, cardiovascular disease is a leading cause of death for both men and women. Epidemiologic studies consistently have suggested an association between low birthweight and/or fetal growth restriction and increased rate of cardiovascular mortality in adulthood. Furthermore, experimental and clinical studies have demonstrated that sustained nutrient and oxygen restriction that are associated with fetal growth restriction activate adaptive cardiovascular changes that might explain this association...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422214/evidence-based-national-guidelines-for-the-management-of-suspected-fetal-growth-restriction-comparison-consensus-and-controversy
#9
REVIEW
Lesley M McCowan, Francesc Figueras, Ngaire H Anderson
Small for gestational age is usually defined as an infant with a birthweight <10th centile for a population or customized standard. Fetal growth restriction refers to a fetus that has failed to reach its biological growth potential because of placental dysfunction. Small-for-gestational-age babies make up 28-45% of nonanomalous stillbirths, and have a higher chance of neurodevelopmental delay, childhood and adult obesity, and metabolic disease. The majority of small-for-gestational-age babies are not recognized before birth...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422208/customized-vs-intergrowth-21st-standards-for-the-assessment-of-birthweight-and-stillbirth-risk-at-term
#10
Andre Francis, Oliver Hugh, Jason Gardosi
BACKGROUND: Fetal growth abnormalities are linked to stillbirth and other adverse pregnancy outcomes, and use of the correct birthweight standard is essential for accurate assessment of growth status and perinatal risk. OBJECTIVE: Two competing, conceptually opposite birthweight standards are currently being implemented internationally: customized gestation-related optimal weight (GROW) and INTERGROWTH-21st. We wanted to compare their performance when applied to a multiethnic international cohort, and evaluate their usefulness in the assessment of stillbirth risk at term...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422204/the-world-health-organization-fetal-growth-charts-concept-findings-interpretation-and-application
#11
REVIEW
Torvid Kiserud, Alexandra Benachi, Kurt Hecher, Rogelio González Perez, José Carvalho, Gilda Piaggio, Lawrence D Platt
Ultrasound biometry is an important clinical tool for the identification, monitoring, and management of fetal growth restriction and development of macrosomia. This is even truer in populations in which perinatal morbidity and mortality rates are high, which is a reason that much effort is put onto making the technique available everywhere, including low-income societies. Until recently, however, commonly used reference ranges were based on single populations largely from industrialized countries. Thus, the World Health Organization prioritized the establishment of fetal growth charts for international use...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422013/first-and-second-trimester-urinary-metabolic-profiles-and-fetal-growth-restriction-an-exploratory-nested-case-control-study-within-the-infant-development-and-environment-study
#12
Gauri Luthra, Ivan Vuckovic, A Bangdiwala, H Gray, J B Redmon, E S Barrett, S Sathyanarayana, R H N Nguyen, S H Swan, S Zhang, P Dzeja, S I Macura, K S Nair
BACKGROUND: Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biological samples, can provide new and earlier biomarkers of prenatal health. Recent research has suggested possible predictive first trimester urine metabolites correlating to fetal growth restriction in the third trimester. Our objective in this current study was to examine urinary metabolic profiles in the first and second trimester of pregnancy in relation to third trimester FGR in a US population from a large, multi-center cohort study of healthy pregnant women...
February 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29417367/chlamydia-trachomatis-and-adverse-pregnancy-outcomes-meta-analysis-of-patients-with-and-without-infection
#13
Courtney Olson-Chen, Kripa Balaram, David N Hackney
OBJECTIVES: We conducted a meta-analysis to determine the association between Chlamydia trachomatis and adverse perinatal outcomes. METHODS: Electronic databases were searched between 1970 and 2013. Included studies reported perinatal outcomes in women with and without chlamydia. Summary odds ratios were calculated using fixed- and random-effects models. Study bias was assessed using a Funnel Plot and Begg's test. RESULTS: Of 129 articles identified, 56 studies met the inclusion criteria encompassing 614,892 subjects...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29406430/abacavir-lamivudine-and-tenofovir-emtricitabine-in-pregnant-women-with-hiv-laboratory-and-clinical-outcomes-in-an-observational-national-study
#14
Marco Floridia, Carmela Pinnetti, Marina Ravizza, Giulia Masuelli, Carlo Personeni, Matilde Sansone, Anna Degli Antoni, Giovanni Guaraldi, Arsenio Spinillo, Beatrice Tassis, Serena Dalzero, Giuseppina Liuzzi, Enrica Tamburrini
BACKGROUND: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational study. METHODS: Laboratory measures (CD4, HIV-RNA, lipid profile, glucose, haemoglobin, ALT) and pregnancy outcomes (preterm delivery, low birthweight, nonelective cesarean section, birthweight Z-score, congenital defects, HIV transmission, maternal weight gain, pregnancy complications) were compared following prenatal exposure to ABC/3TC or TDF/FTC...
February 5, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29403153/postnatal-bmi-changes-in-children-with-different-birthweights-a-trial-study-for-detecting-early-predictive-factors-for-pediatric-obesity
#15
Yuichi Nakagawa, Toshiki Nakanishi, Eiichiro Satake, Rie Matsushita, Hirokazu Saegusa, Akira Kubota, Hiromune Natsume, Yukinobu Shibata, Yasuko Fujisawa
The purpose of this study was to clarify the degree of early postnatal growth by birthweight and detect early predictive factors for pediatric obesity. Body mass index (BMI) and degree of obesity were examined in children in the fourth year of elementary school and second year of junior high school. Their BMI at birth and three years of age were also examined. Based on birthweight, participants were divided into three groups: low (< 2500 g), middle (2500-3500 g), and high (> 3500 g). Furthermore, according to the degree of obesity, they were divided into two groups: obese (20% ≤) and non-obese (20% >)...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29401677/adverse-pregnancy-outcomes-among-adolescents-in-northwest-russia-a-population-registry-based-study
#16
Anna A Usynina, Vitaly Postoev, Jon Øyvind Odland, Andrej M Grjibovski
This study aimed to assess whether adolescents have an increased risk of adverse pregnancy outcomes (APO) compared to adult women. We used data on 43,327 births from the population-based Arkhangelsk County Birth Registry, Northwest Russia, for 2012-2014. The perinatal outcomes included stillbirth, preterm birth (<37 and <32 weeks), low and very low birthweight, 5 min Apgar score <7 and <4, perinatal infections, and the need for neonatal transfer to a higher-level hospital. Multivariable logistic regression was applied to assess the associations between age and APO...
February 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29395997/prevention-of-malaria-in-pregnancy
#17
REVIEW
Meghna Desai, Jenny Hill, Silke Fernandes, Patrick Walker, Christopher Pell, Julie Gutman, Kassoum Kayentao, Raquel Gonzalez, Jayne Webster, Brian Greenwood, Michel Cot, Feiko O Ter Kuile
Malaria remains one of the most preventable causes of adverse birth outcomes. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine is used to prevent malaria, but resistance to this drug combination has decreased its efficacy and new alternatives are needed. In Africa, a meta-analysis showed three-course or monthly IPTp with sulfadoxine-pyrimethamine to be safe and more effective than the original two-course sulfadoxine-pyrimethamine strategy, prompting WHO to update its policy in 2012...
January 30, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29395887/palivizumab-administration-in-preterm-infants-in-france-epipage-2-cohort-study
#18
H Torchin, J Rousseau, L Marchand-Martin, P Truffert, P-H Jarreau, P-Y Ancel
BACKGROUND: Several countries, including France, have restricted the indications for monoclonal antibodies directed against respiratory syncytial virus (RSV) compared to the marketing authorization (MA). No new data concerning use of palivizumab on a national scale have been published since the 2007 update of the national guidelines. OBJECTIVES: To describe palivizumab administration for RSV prophylaxis during the first RSV season in infants born prematurely in France in 2011...
January 27, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29394890/incidence-aetiology-and-outcomes-of-obstetric-related-acute-kidney-injury-in-malawi-a-prospective-observational-study
#19
William R Cooke, Ulla K Hemmilä, Alison L Craik, Chimwemwe J Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer, Rhys Evans
BACKGROUND: Obstetric-related acute kidney injury (AKI) is thought to be a key contributor to the overall burden of AKI in low resource settings, causing significant and preventable morbidity and mortality. However, epidemiological data to corroborate these hypotheses is sparse. This prospective observational study aims to determine the incidence, aetiology and maternal-fetal outcomes of obstetric-related AKI in Malawi. METHODS: Women greater than 20 weeks gestation or less than 6 weeks postpartum admitted to obstetric wards at a tertiary hospital in Blantyre, Malawi, and at high-risk of AKI were recruited between 21st September and 11th December 2015...
February 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29394356/carriage-of-cronobacter-sakazakii-in-the-very-preterm-infant-gut
#20
Sukantha Chandrasekaran, Carey-Ann D Burnham, Barbara B Warner, Phillip I Tarr, Todd N Wylie
Background: Cronobacter sakazakii causes severe neonatal infections, but we know little about gut carriage of this pathogen in very low birthweight infants. Methods: We sequenced 16S rRNA genes from 2,304 stools from 121 children at St. Louis Children's Hospital whose birthweight was ≤1,500 grams, attempted to isolate C. sakazakii from 157 of these stools, genome sequenced the recovered isolates, and sought correlations between indices of Cronobacter excretion, host characteristics and unit formula use...
January 31, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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