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https://www.readbyqxmd.com/read/29677556/prenatal-exposure-to-polychlorinated-biphenyls-and-fetal-growth-in-british-girls
#1
Jill F Patel, Terryl J Hartman, Andreas Sjodin, Kate Northstone, Ethel V Taylor
Polychlorinated biphenyls (PCBs) are synthetic chemicals that bioaccumulate in the food chain. PCBs were used primarily for industrial applications due to their insulating and fire retardant properties, but were banned in the 1970s in the United States and in the 1980s in the United Kingdom, as adverse health effects following exposure were identified. Previous studies of populations with high PCB exposure have reported inverse associations with birth weight and gestational length. Birth weight is a powerful predictor of infant survival, and low birth weight can predispose infants to chronic conditions in adult life such as diabetes and cardiovascular diseases...
April 17, 2018: Environment International
https://www.readbyqxmd.com/read/29673729/perinatal-outcomes-following-ivf-with-use-of-donor-versus-partner-sperm
#2
Mohan Shashikant Kamath, Belavendra Antonisamy, Hepsy Y Selliah, Antonio La Marca, Sesh Kamal Sunkara
It is a matter of interest whether pregnancies with the use of donor sperm are associated with a higher risk of adverse perinatal outcomes compared with partner sperm. Anonymized data were obtained from the Human Fertilization & Embryology Authority. Data from 1991 to 2011 involving a total of 95,787 singleton births (4523 with donor sperm and 91,264 with partner sperm) following fresh IVF/intracytoplasmic sperm injection (ICSI) were analysed to compare perinatal outcomes of preterm birth (PTB), low birthweight (LBW) and high birthweight (HBW)...
April 6, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29650428/-extrauterine-growth-restriction-among-neonates-with-a-birthweight-less-than-1-500grams
#3
Alejandro Avila-Alvarez, Alfonso Solar Boga, Carmen Bermúdez-Hormigo, Jesús Fuentes Carballal
INTRODUCTION: Growth restriction in preterm infants has been related to a poor neurodevelopment outcome. OBJECTIVES: To define the incidence of postnatal growth restriction in premature babies ≤1,500 grams and to detect related clinical or biochemical markers. METHODS: Retrospective longitudinal observational study. Multivariate linear regression models were used to determine variables that can predict the change in weight z-score during admission...
April 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29649918/the-impact-of-unicornuate-uterus-on-perinatal-outcomes-after-ivf-icsi-cycles-a-matched-retrospective-cohort-study
#4
Xinxia Chen, Peihao Liu, Yan Sheng, Weiping Li, Rong Tang, Lingling Ding, Yingying Qin, Zi-Jiang Chen
OBJECTIVE: To evaluate the impact of unicornuate uterus on perinatal outcomes after in vitro fertilization and/or intracytoplasmic sperm injection (IVF/ICSI) cycles. METHODS: We performed a retrospective cohort study including 160 women with unicornuate uterus and 1:1 matched controls with normally shaped uterus. They received IVF/ICSI treatment during January 2009 and December 2011. The perinatal outcomes were followed up till December 2014. RESULTS: There were no significant differences in pregnancy rate, clinical pregnancy rate or live birth rate (53...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29648569/the-childhood-role-in-development-of-primary-hypertension
#5
Bonita Falkner
Primary hypertension is not just an adult disorder. Current US population data on children and adolescents demonstrate a prevalence of elevated blood pressure (BP) and hypertension combined of over 10%. Recent reports from prospective cohort studies describe an association of high BP in childhood with hypertension in young adulthood. Excess adiposity is strongly associated with higher BP in childhood and increases risk for hypertension in adulthood. In addition to overweight/obesity, other exposures that raise the risk for high BP include low birthweight, dietary sodium, and stress...
April 10, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29642382/a-low-glycaemic-index-diet-in-pregnancy-induces-dna-methylation-variation-in-blood-of-newborns-results-from-the-rolo-randomised-controlled-trial
#6
Aisling A Geraghty, Alexandra Sexton-Oates, Eileen C O'Brien, Goiuri Alberdi, Peter Fransquet, Richard Saffery, Fionnuala M McAuliffe
The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal diet has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. We investigated the impact of a low glycaemic index dietary intervention during pregnancy on offspring DNA methylation patterns using a genome-wide methylation approach. Sixty neonates were selected from the ROLO (Randomised cOntrol trial of LOw glycaemic index diet to prevent macrosomia) study: 30 neonates from the low glycaemic index intervention arm and 30 from the control, whose mothers received no specific dietary advice...
April 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29627351/placental-growth-factor-informed-management-of-suspected-pre-eclampsia-or-fetal-growth-restriction-the-mapple-cohort-study
#7
Andrew Sharp, Lucy C Chappell, Gustaaf Dekker, Sanja Pelletier, Yves Garnier, Onur Zeren, Katharina M Hillerer, Thorsten Fischer, Paul T Seed, Mark Turner, Andrew H Shennan, Zarko Alfirevic
OBJECTIVES: Placental Growth Factor (PlGF) has been shown to be beneficial in diagnosing pre-eclampsia. We performed a prospective cohort study of revealed PlGF in standard clinical use in four teaching hospitals in UK, Germany, Austria and Australia. STUDY DESIGN: Clinical data from women with suspected pre-eclampsia or fetal growth restriction <35 weeks' gestation with revealed PlGF measurement were collected (MAPPLE study). MAIN OUTCOME MEASURES: Data were compared to the PELICAN study (PlGF concealed)...
March 26, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29626981/placental-lipoprotein-lipase-activity-is-positively-associated-with-newborn-adiposity
#8
Margaret J R Heerwagen, Diane L Gumina, Teri L Hernandez, Rachael E Van Pelt, Anita W Kramer, Rachel C Janssen, Dalan R Jensen, Theresa L Powell, Jacob E Friedman, Virginia D Winn, Linda A Barbour
INTRODUCTION: Recent data suggest that in addition to glucose, fetal growth is related to maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids (FFA) and transported across the placenta, but regulation is uncertain. Placental lipoprotein lipase (pLPL) hydrolyzes TG, both dietary chylomicron TG (CM-TG) and very-low density lipoprotein TG (VLDL-TG), to FFA. This may promote fetal fat accretion by increasing the available FFA pool for placental uptake...
April 2018: Placenta
https://www.readbyqxmd.com/read/29616897/singleton-low-birthweight-rates-by-race-and-hispanic-origin-united-states-2006-2016
#9
Lindsay S Womack, Lauren M Rossen, Joyce A Martin
Low birthweight (LBW) is among the leading causes of infant death in the United States (1). LBW infants are also more likely to have health problems (2). After reaching its highest level in four decades, the LBW rate among all births declined from 2006 to 2014 (3,4), but the trend reversed in 2015 and 2016 when the LBW rate increased (4), moving further away from the Healthy People 2020 goal of reducing LBW rates to 7.8% of live births (5). This report shows trends in LBW, moderately low birthweight (MLBW), and very low birthweight (VLBW) by race and Hispanic origin from 2006 to 2016 for singleton births only, as rates of multiple births can impact LBW rates (4,6)...
March 2018: NCHS Data Brief
https://www.readbyqxmd.com/read/29615483/incidence-of-hypocapnia-hypercapnia-and-acidosis-and-the-associated-risk-of-adverse-events-in-preterm-neonates
#10
Melissa K Brown, Deborah M Poeltler, Kasim O Hassen, Danielle V Lazarus, Vanessa K Brown, Jeremiah J Stout, Wade D Rich, Anup C Katheria
BACKGROUND: Permissive hypercapnia is a lung-protection strategy. We sought to review our current clinical practice for the range of permissive hypercapnia and identify the relationship between P aCO2 and pH and adverse outcomes. METHODS: A secondary analysis of a delayed cord-clamping clinical trial was performed on all arterial blood gas tests in the first 72 h in infants < 32 weeks gestational age. All arterial blood gas values were categorized into a clinical range to determine the percent likelihood of occurring in the total sample...
April 3, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29607328/maternal-fetal-and-neonatal-outcomes-in-pregnant-dengue-patients-in-mexico
#11
Carlos Machain-Williams, Eric Raga, Carlos M Baak-Baak, Sungmin Kiem, Bradley J Blitvich, Celso Ramos
To increase our understanding of the consequences of dengue virus infection during pregnancy, a retrospective analysis was performed on the medical records of all completed pregnancies (live births and pregnancy losses) at nine public hospitals in the Gulf of Mexico from January to October 2013. Eighty-two patients developed clinical, laboratory-confirmed dengue virus infections while pregnant. Of these, 54 (65.9%) patients were diagnosed with dengue without warning signs, 15 (18.3%) patients were diagnosed with dengue with warning signs, and 13 (15...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29606018/relationships-between-psychosocial-distress-and-diet-during-pregnancy-and-infant-birthweight-in-a-lower-middle-income-country-healthy-mothers-healthy-communities-study-in-vanuatu
#12
Alysa Pomer, Giavana Buffa, Fasiah Taleo, J Hunter Sizemore, Apisai Tokon, George Taleo, Len Tarivonda, Chim W Chan, Akira Kaneko, Kelsey N Dancause
BACKGROUND: Maternal stress during pregnancy is associated with birth outcomes, including birthweight. Exposure to natural disasters during pregnancy provides a model to study these relationships. However, few studies assess both stress and diet, which might have interactive effects. Furthermore, most are conducted in high-income countries. Patterns might differ in low- and middle-income countries (LMICs). AIM: To study relationships between stress and diet during pregnancy, and infant birthweight, following a natural disaster in a lower-middle income country...
April 1, 2018: Annals of Human Biology
https://www.readbyqxmd.com/read/29602257/neonatal-oesophageal-perforation-the-role-for-non-operative-management
#13
Kate Hodgson, Andrea Togo, Aideen M Moore, Amanda Moody, Sebastian K King, Augusto Zani
AIM: Isolated oesophageal perforation in neonates is a rare but potentially life-threatening condition. Although management has historically been operative, conservative management (antibiotics, bowel rest, parenteral nutrition) is now more routinely used. The aim of this study was to evaluate the management of this condition in two large neonatal surgical centres. METHODS: A retrospective cohort study was conducted for neonates admitted to The Hospital for Sick Children (Toronto, Canada) or The Royal Children's Hospital (Melbourne, Australia) with a diagnosis of oesophageal perforation, from 2006 to 2016...
March 30, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29601596/an-anthropometric-approach-to-characterising-neonatal-morbidity-and-body-composition-using-air-displacement-plethysmography-as-a-criterion-method
#14
Jacqueline Huvanandana, Angela E Carberry, Robin M Turner, Emily J Bek, Camille H Raynes-Greenow, Alistair L McEwan, Heather E Jeffery
BACKGROUND: With the greatest burden of infant undernutrition and morbidity in low and middle income countries (LMICs), there is a need for suitable approaches to monitor infants in a simple, low-cost and effective manner. Anthropometry continues to play a major role in characterising growth and nutritional status. METHODS: We developed a range of models to aid in identifying neonates at risk of malnutrition. We first adopted a logistic regression approach to screen for a composite neonatal morbidity, low and high body fat (BF%) infants...
2018: PloS One
https://www.readbyqxmd.com/read/29600727/clinical-and-neonatal-outcomes-of-intrauterine-insemination-with-frozen-donor-sperm
#15
Linjun Chen, Lihua Zhu, Changming Cai, Guijun Yan, Haixiang Sun
This retrospective study evaluated the association between frozen donor sperm used for intrauterine insemination and clinical and neonatal outcomes, including 304 singleton pregnancies resulting from artificial insemination by the husband (AIH) and 173 singleton pregnancies resulting from artificial insemination by a donor (AID). The clinical outcomes for AID showed no increased risk of abortion, ectopic pregnancy or pregnancy complications compared to those for AIH. There were no differences in gender, gestational age or prematurity of live births between the two groups...
March 30, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29587540/risk-of-recurrent-shoulder-dystocia-are-we-any-closer-to-prediction
#16
Shadha Al-Hawash, Clare L Whitehead, Dan Farine
OBJECTIVE: To determine the incidence and risk factors for recurrent shoulder dystocia in women. METHODS: We searched Medline, Pubmed, Embase, and CINAHL for relevant articles in English and French from 1980 to February 2018 that described risks of recurrent shoulder dystocia undergoing a trial of labour in subsequent pregnancies. A total of 684 articles were found, of which 13 were included as they met criteria. We extracted data on study characteristics, incidence of recurrent shoulder dystocia, degree of neonatal injury, and presence of known risk factors...
March 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29581725/comparison-of-the-screening-tests-for-gestational-diabetes-mellitus-between-one-step-and-two-step-methods-among-thai-pregnant-women
#17
Suchaya Luewan, Phenphan Bootchaingam, Theera Tongsong
Objective: To compare the prevalence and pregnancy outcomes of GDM between those screened by the "one-step" (75 gm GTT) and "two-step" (100 gm GTT) methods. Methods: A prospective study was conducted on singleton pregnancies at low or average risk of GDM. All were screened between 24 and 28 weeks, using the one-step or two-step method based on patients' preference. The primary outcome was prevalence of GDM, and secondary outcomes included birthweight, gestational age, rates of preterm birth, small/large-for-gestational age, low Apgar scores, cesarean section, and pregnancy-induced hypertension...
2018: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/29573301/early-death-and-causes-of-death-of-people-with-down-syndrome-a-systematic-review
#18
Lisa O'Leary, Laura Hughes-McCormack, Kirsty Dunn, Sally-Ann Cooper
BACKGROUND: It is thought that people with Down syndrome die younger than the general population, but that survival rates are improving. METHODS: Five databases were searched for keywords related to intellectual disabilities, Down syndrome and mortality. Strict inclusion criteria were applied. Information from 34 selected studies was tabulated, extracted and synthesized. RESULTS: People with Down syndrome died about 28 years younger than the general population...
March 24, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29566009/metabolomic-signatures-of-low-birthweight-pathways-to-insulin-resistance-and-oxidative-stress
#19
Sarah Jane Metrustry, Ville Karhunen, Mark H Edwards, Cristina Menni, Thomas Geisendorfer, Anja Huber, Christian Reichel, Elaine M Dennison, Cyrus Cooper, Tim Spector, Marjo-Riitta Jarvelin, Ana M Valdes
Several studies suggest that low birthweight resulting from restricted intrauterine growth can leave a metabolic footprint which may persist into adulthood. To investigate this, we performed metabolomic profiling on 5036 female twins, aged 18-80, with weight at birth information available from the TwinsUK cohort and performed independent replication in two additional cohorts. Out of 422 compounds tested, 25 metabolites associated with birthweight in these twins, replicated in 1951 men and women from the Hertfordshire Cohort Study (HCS, aged 66) and in 2391 men and women from the North Finland Birth 1986 cohort (NFBC, aged 16)...
2018: PloS One
https://www.readbyqxmd.com/read/29561286/top-five-legal-pitfalls-in-retinopathy-of-prematurity
#20
Darius M Moshfeghi
PURPOSE OF REVIEW: This review highlights the common areas of medicolegal risk during retinopathy of prematurity (ROP) screening. RECENT FINDINGS: Most malpractice risk in ROP comes from systemic errors that ultimately result in failure to screen the patient in a timely fashion, resulting in failures to intervene and/or refer in a timely fashion. Currently, the emphasis is engaging the family members, the hospital staff, and clinic staff to pro-actively manage ROP patients and ensure that they are screened in a timely fashion...
May 2018: Current Opinion in Ophthalmology
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