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Low birthweight

Atsushi Uchiyama, Hirokazu Watanabe, Hidehiko Nakanishi, Satsuki Totsu
OBJECTIVE: Delayed thyrotropin (TSH) elevation (dTSHe) is common in low birthweight infants. We aimed to clarify the risk factors for the development of dTSHe in infants weighing <2000 g at birth. PATIENTS AND METHODS: According to Japanese guidelines, infants with birthweight <2000 g underwent second capillary TSH screening within 30 days, either at one month of age; or when weight reached 2.5 kg; or at discharge. dTSHe was defined as TSH >20 mIU/L by venous sampling following a normal result (<15 mIU/L) at first screening aged 4-6 days...
June 19, 2018: Clinical Endocrinology
Varangthip Khuwuthyakorn, Chuleeporn Jatuwattana, Suchaya Silvilairat, Watcharee Tantiprapha
Background In low- and middle-income countries (LMIC), haemodynamically significant patent ductus arteriosus (hsPDA) is treated with oral indomethacin (IDC) and ibuprofen (IB) instead of intravenous formulations. No significant differences in efficacy have been reported. However, previous studies had small numbers of VLBW infants (<1500 g). Objective To evaluate the efficacy of oral IDC and IB for closing PDA in VLBW infants with a gestational age of 24-32 weeks. Methods This randomised controlled study enrolled 32 infants with hsPDA for treatment with either three doses of oral IDC or oral IB...
June 18, 2018: Paediatrics and International Child Health
Meenakshi S Subbaraman, Sue Thomas, Ryan Treffers, Kevin Delucchi, William C Kerr, Priscilla Martinez, Sarah C M Roberts
BACKGROUND: Policies regarding alcohol use during pregnancy continue to be enacted and debated in the United States. However, no study to date has examined whether these policies are related to birth outcomes, the outcomes they ultimately aim to improve. Here we assessed whether state-level policies targeting alcohol use during pregnancy are related to birth outcomes, which has not been done comprehensively before. METHODS: Secondary analyses of birth certificate data from N=148,048,208 United States singleton births between 1972-2013...
June 18, 2018: Alcoholism, Clinical and Experimental Research
Karen T Chang, Luke C Mullany, Subarna K Khatry, Steven C LeClerq, Melinda K Munos, Joanne Katz
Background: Tracking progress towards global newborn health targets depends largely on maternal reported data collected through large, nationally representative surveys. We evaluated the validity, across a range of recall period lengths (1 to 24 months post-delivery), of maternal report of birthweight, birth size and length of pregnancy. Methods: We compared maternal reports to reference standards of birthweights measured within 72 hours of delivery and gestational age generated from reported first day of the last menstrual period (LMP) prospectively collected as part of a population-based study (n = 1502)...
June 2018: Journal of Global Health
P Naidoo, R N Naidoo, P Ramkaran, S Muttoo, K Asharam, A A Chuturgoon
OBJECTIVE: Nitrogen oxide (NOx) pollution and human immunodeficiency virus (HIV)/AIDS intensify inflammation during pregnancy and linked with adverse birth outcomes (ABOs). MicroRNA (miRNA)-146a plays a crucial role in regulating inflammation in the NF-κB pathway. The G/C rs2910164 dampens miRNA-146a activity and linked with inflammatory diseases. The present study investigated whether HIV/AIDS and NOx exposure throughout pregnancy further intensifies ABO in Black South African women genotyped for the rs2910164...
January 1, 2018: Human & Experimental Toxicology
Kelvin C Fong, Itai Kloog, Brent A Coull, Petros Koutrakis, Francine Laden, Joel D Schwartz, Peter James
Natural vegetation, or greenness, may benefit maternal health and consequently, fetal growth, by providing opportunities for physical activity and psychological restoration, and decreasing detrimental environmental exposures. We retrieved Massachusetts Birth Registry data from 2001⁻2013 and investigated the association between residential greenness and birthweight in full-term births (&ge;37 weeks gestation). We calculated average residential greenness during pregnancy using 250 m normalized difference vegetation index (NDVI) from satellites...
June 12, 2018: International Journal of Environmental Research and Public Health
Melanie C Audette, Khrystyna Levytska, Stephen J Lye, Nir Melamed, John C Kingdom
INTRODUCTION: Rates of some placental-associated pregnancy complications vary by ethnicity, though the strength of association with underlying placental pathology is presently unknown. Our objective was to determine whether an association between ethnicity and placental pathology occurs in low-risk pregnancies. METHODS: 829 low-risk nulliparous pregnant women were prospectively studied. Data were obtained from standardized obstetrical appointments (clinical history, serum biomarkers, placental ultrasound) and hospital delivery records (pregnancy complications, delivery details and perinatal outcomes)...
June 2018: Placenta
Beata Marciniak, Jolanta Patro-Małysza, Żaneta Kimber-Trojnar, Jan Oleszczuk, Bożena Leszczyńska-Gorzelak
PURPOSE: The aim of this paper is to identify predictors of cesarean delivery (CD) in patients with an unfavorable cervix undergoing cervical ripening and labor induction with Foley catheter. MATERIALS AND METHODS: A retrospective cohort study of singleton pregnancies induced using Foley catheter was performed to evaluate whether factors in the maternal history and during the process of labor induction are useful in predicting the risk of CD. RESULTS: During the study period there were 2...
June 7, 2018: Journal of Maternal-fetal & Neonatal Medicine
Keiji Yamana, Sota Iwatani, Kazumichi Fujioka, Kazumoto Iijima, Ichiro Morioka
No abstract text is available yet for this article.
May 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Daniela Zanetti, Emmi Tikkanen, Stefan Gustafsson, James R Priest, Stephen Burgess, Erik Ingelsson
BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower birthweight is causal for these diseases, but causality is difficult to infer from observational studies. METHODS: We performed regression analyses to assess associations of birthweight with cardiovascular disease and T2D in 237 631 individuals from the UK Biobank...
June 2018: Circulation. Genomic and precision medicine
Hadia Radwan, Mona Hashim, Reyad Shaker Obaid, Hayder Hasan, Farah Naja, Hessa Al Ghazal, Hamid Jan Jan Mohamed, Rana Rizk, Marwa Al Hilali, Rana Rayess, Ghamra Izzaldin
BACKGROUND: The United Arab Emirates (UAE) exhibits alarming high prevalence of Non-Communicable Diseases (NCDs) and their risk factors. Emerging evidence highlighted the role of maternal and early child nutrition in preventing later-onset NCDs. The objectives of this article are to describe the design and methodology of the first Mother and Infant Study Cohort (MISC) in UAE; present the baseline demographic characteristics of the study participants; and discuss the challenges of the cohort and their respective responding strategies...
2018: PloS One
Jie Hu, Wei Xia, Xinyun Pan, Tongzhang Zheng, Bin Zhang, Aifen Zhou, Stephen L Buka, Bryan A Bassig, Wenyu Liu, Chuansha Wu, Yang Peng, Jun Li, Chuncao Zhang, Hongxiu Liu, Minmin Jiang, Youjie Wang, Jianduan Zhang, Zheng Huang, Dan Zheng, Kunchong Shi, Zhengmin Qian, Yuanyuan Li, Shunqing Xu
BACKGROUND: Vanadium, an important pollutant produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in animal studies. However, little is known about its effects on humans. We aimed to assess the association of prenatal exposure to vanadium with the risk of adverse birth outcomes in babies born to women in China. METHODS: For this population-based cohort study, the Healthy Baby Cohort, women were recruited from three cities in Hubei Province, China...
September 2017: Lancet. Planetary Health
Ngaire Anderson, Monique De Laat, Samantha Benton, Peter Dadelszen, Lesley McCowan
BACKGROUND: At-risk small-for-gestational age (SGA) pregnancies in New Zealand are identified using Doppler ultrasound; fetuses with Doppler abnormalities are considered growth restricted (FGR). Low maternal placental growth factor (PlGF) has also been associated with late-onset FGR. AIMS: To investigate whether low PlGF at diagnosis of late-onset SGA identifies the same fetuses classified FGR by detailed Doppler studies, and the association between low PlGF and adverse pregnancy outcomes...
May 31, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Ashok Kumar Dutta
No abstract text is available yet for this article.
May 15, 2018: Indian Pediatrics
Na Wang, Weina Lu, Yongliang Xu, Shuhui Mao, Man He, Xihua Lin, Jiaqiang Zhou
AIM: This study sought to determine the rate of recurrence of gestational diabetes mellitus (GDM) recurrence during the second pregnancies of women who were diagnosed with GDM during their first pregnancies, to identify risk factors associated with the probability of such recurrence and to evaluate the influence of GDM recurrence on pregnancy outcomes in north Zhejiang, China, after the recent adjustment to the nation's childbirth policy. METHODS: A retrospective longitudinal study was performed in north Zhejiang, China (at Jiaxing Maternal and Child Health Hospital)...
May 29, 2018: Journal of Obstetrics and Gynaecology Research
Xin Huang, Hongzhuan Tan, Ming Cai, Ting Shi, Chunmei Mi, Jun Lei
BACKGROUND: The generalizability of the gestational weight gain (GWG) ranges recommended by the Institute of Medicine (IOM) to Chinese women is disputed. METHODS: In 2016, 16,780 pregnant women who gave birth to live singletons in Changsha, China, were enrolled. First, subjects with optimal pregnancy outcomes were identified for the GWG percentile distribution description and for comparison to the IOM recommendations. Second, all subjects with optimal GWG according to the IOM body mass index (BMI) cutoffs and those with optimal GWG according to the Asian BMI cutoffs were selected...
May 29, 2018: BMC Pregnancy and Childbirth
Malachi Ochieng Arunda, Anette Agardh, Benedict Oppong Asamoah
BACKGROUND: Although low birthweight (LBW) babies represent only 15.5% of global births, it is the leading underlying cause of deaths among newborns in countries where neonatal mortality rates are high. In Uganda, like many other sub-Saharan African countries, the progress of reducing neonatal mortality has been slow and the contribution of low birthweight to neonatal deaths over time is unclear. The aim of this study is to investigate the association between low birthweight and neonatal mortality and to determine the trends of neonatal deaths attributable to low birthweight in Uganda between 1995 and 2011...
May 30, 2018: BMC Pregnancy and Childbirth
Sol Juárez, Eleonora Mussino, Anders Hjern
AIMS: to evaluate whether the information on refugee status based on the residence permit is a useful source of information for perinatal health surveillance. METHODS: Using the Swedish population registers (1997-2012), we use multinomial regression models to assess the associations between migration status (refugee and non-refugee) and birth outcomes derived from birthweight and gestational age: low birthweight (LBW) (<2500 g), macrosomia (≥4000 g); preterm: (<37 w) and post-term (≥42 w)...
May 1, 2018: Scandinavian Journal of Public Health
Didier Tshamala, Anita Pelecanos, Mark W Davies
AIM: To determine the proportion of very preterm infants who were exclusively fed breast milk at the time of discharge home, before and after the availability of pasteurised donor human milk (PDHM). METHODS: This was an observational retrospective cohort study with historical comparison, comparing two cohorts (<32 weeks gestational age or very low birthweight) before and after the availability of donor human milk. The main explanatory variable was the PDHM cohort: pre-PDHM or post-PDHM...
May 28, 2018: Journal of Paediatrics and Child Health
Katherine L Grantz, Sungduk Kim, William A Grobman, Roger Newman, John Owen, Daniel Skupski, Jagteshwar Grewal, Edward K Chien, Deborah A Wing, Ronald J Wapner, Angela C Ranzini, Michael P Nageotte, Stefanie N Hinkle, Sarah Pugh, Hanyun Li, Karin Fuchs, Mary Hediger, Germaine M Buck Louis, Paul S Albert
BACKGROUND: Accurately identifying pregnancies with accelerated or diminished fetal growth is challenging and generally based on cross-sectional percentile estimates of fetal weight. Longitudinal growth velocity might improve identification of abnormally grown fetuses. OBJECTIVES: To complement fetal size standards with fetal growth velocity, develop a model to compute fetal growth velocity percentiles for any given set of gestational week intervals, and determine association between fetal growth velocity and birthweight...
May 24, 2018: American Journal of Obstetrics and Gynecology
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