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https://www.readbyqxmd.com/read/29032242/combination-of-vitamin-b12-active-forms-improved-fetal-growth-in-wistar-rats-through-up-regulation-of-placental-mir-16-and-mir-21-levels
#1
Tejas Shah, Sanjay Mishra, Amol More, Suhas Otiv, Kishori Apte, Kalpana Joshi
Aim Epidemiological studies have indicated importance of folate and vitamin (B12) during pregnancy. Also available evidence on efficacy of B12 forms viz. Cyanocobalamin (Cbl), Methylcobalamin (MeCbl), Adenosylcobalamin (AdCbl) and Hydroxycobalamin (HCbl) in preventing or treating cobalamin deficiency is limited. The present study examines the effect of various B12 forms in combination with folate during pregnancy and their effect on gestational outcomes. MAIN METHOD: In the present study, we examined the effect of various vitamin B12 forms in presence of recommended folate (RFol: 400μg/day) and high folate (HFol: 5mg/day) on gestational outcomes in female Wistar rats...
October 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/29029337/protective-effect-of-indoor-residual-spraying-of-insecticide-on-preterm-birth-among-pregnant-women-with-hiv-in-uganda-a-secondary-data-analysis
#2
Michelle E Roh, Stephen Shiboski, Paul Natureeba, Abel Kakuru, Mary Muhindo, Teddy Ochieng, Albert Plenty, Catherine A Koss, Tamara D Clark, Patricia Awori, Miriam Nakalambe, Deborah Cohan, Prasanna Jagannathan, Roly Gosling, Diane V Havlir, Moses R Kamya, Grant Dorsey
Background: Recent evidence demonstrated improved birth outcomes among HIV-uninfected pregnant women protected by indoor residual spraying of insecticide (IRS). Evidence regarding its impact on HIV-infected pregnant women is lacking. Methods: Data were pooled from two studies conducted before-and-after an IRS campaign in Tororo, Uganda among HIV-infected pregnant women who received bednets, daily trimethoprim-sulfamethoxazole (TMP-SMX), and combination antiretroviral therapy (c-ART) at enrollment...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29027730/psychological-distress-in-post-partum-women-after-non-invasive-prenatal-testing-nipt-in-japan
#3
Eri Takeda, Nobuhiro Suzumori, Takeshi Ebara, Junko Yotsumoto, Kyoko Kumagai, Kumiko Oseto, Hironao Numabe, Mayumi Sugiura-Ogasawara
AIM: The purpose of this study was to clarify the characteristics of psychological mental distress in post-partum women after non-invasive prenatal testing (NIPT) in Japan. METHODS: Psychological mental distress was assessed using the Kessler Psychological Distress Scale (K6). We compared patients with (i) low pre-NIPT K6 and low post-partum K6 scores (control group), and (ii) low pre-NIPT K6 and a high post-partum K6 scores (case group). RESULTS: Among the 697 women who underwent NIPT, 29 (4...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29025632/modifiers-of-the-effect-of-maternal-multiple-micronutrient-supplementation-on-stillbirth-birth-outcomes-and-infant-mortality-a-meta-analysis-of-individual-patient-data-from-17-randomised-trials-in-low-income-and-middle-income-countries
#4
Emily R Smith, Anuraj H Shankar, Lee S-F Wu, Said Aboud, Seth Adu-Afarwuah, Hasmot Ali, Rina Agustina, Shams Arifeen, Per Ashorn, Zulfiqar A Bhutta, Parul Christian, Delanjathan Devakumar, Kathryn G Dewey, Henrik Friis, Exnevia Gomo, Piyush Gupta, Pernille Kæstel, Patrick Kolsteren, Hermann Lanou, Kenneth Maleta, Aissa Mamadoultaibou, Gernard Msamanga, David Osrin, Lars-Åke Persson, Usha Ramakrishnan, Juan A Rivera, Arjumand Rizvi, H P S Sachdev, Willy Urassa, Keith P West, Noel Zagre, Lingxia Zeng, Zhonghai Zhu, Wafaie W Fawzi, Christopher R Sudfeld
BACKGROUND: Micronutrient deficiencies are common among women in low-income and middle-income countries. Data from randomised trials suggest that maternal multiple micronutrient supplementation decreases the risk of low birthweight and potentially improves other infant health outcomes. However, heterogeneity across studies suggests influence from effect modifiers. We aimed to identify individual-level modifiers of the effect of multiple micronutrient supplements on stillbirth, birth outcomes, and infant mortality in low-income and middle-income countries...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29020221/systemic-inflammatory-response-to-malaria-during-pregnancy-is-associated-with-pregnancy-loss-and-preterm-delivery
#5
Michal Fried, Jonathan D Kurtis, Bruce Swihart, Sunthorn Pond-Tor, Amadou Barry, Youssoufa Sidibe, Santara Gaoussou, Moussa Traore, Sekouba Keita, Almahamoudou Mahamar, Oumar Attaher, Adama B Dembele, Kadidia B Cisse, Bacary S Diarra, Moussa B Kanoute, Alassane Dicko, Patrick E Duffy
Background: Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor-α, interferon-γ, interleukin 10 (IL-10), and CXCL9. These changes are associated with poor outcomes including low birthweight delivery and maternal anemia. However, it is unknown if inflammatory pathways during malaria are related to pregnancy loss and preterm delivery (PTD). Methods: Cytokine and chemokine levels were measured in maternal peripheral blood at enrollment, gestational week 30-32, and delivery, and in placental blood, of 638 women during a longitudinal cohort study in Ouelessebougou, Mali...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28990592/maternal-and-fetal-genetic-contribution-to-gestational-weight-gain
#6
N M Warrington, R Richmond, B Fenstra, R Myhre, R Gaillard, L Paternoster, C A Wang, R N Beaumont, S Das, M Murcia, S J Barton, A Espinosa, E Thiering, M Atalay, N Pitkänen, I Ntalla, A E Jonsson, R Freathy, V Karhunen, C M T Tiesler, C Allard, A Crawford, S M Ring, M Melbye, P Magnus, F Rivadeneira, L Skotte, T Hansen, J Marsh, M Guxens, J W Holloway, H Grallert, V W V Jaddoe, W L Lowe, T Roumeliotaki, A T Hattersley, V Lindi, K Pahkala, K Panoutsopoulou, M Standl, C Flexeder, L Bouchard, E A Nohr, L S Marina, M Kogevinas, H Niinikoski, G Dedoussis, J Heinrich, R M Reynolds, T Lakka, E Zeggini, O T Raitakari, L Chatzi, H M Inskip, M Bustamante, M-F Hivert, M-R Jarvelin, T I A Sørensen, C Pennell, J F Felix, B Jacobsson, F Geller, D M Evans, D A Lawlor
BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG...
October 9, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28989948/morbidity-in-%C3%A2-1500-gram-births-in-spain-1993-2011-study-of-a-sample-of-1200-cases
#7
Concepción Gómez Esteban, Juan J Sánchez Carrión, Fernando J García Selgas, José M Segovia Guisado
Background and Objective. Preterm birth has a major impact on growth, and very preterm birth is associated with disabilities in numerous developmental domains. This article describes and quantifies morbidities in a sample of 1200 ≤1500-g births in Spain between 1993 and 2011 based on parent information, and it highlights several variables that influence these morbidities. Methods. Multiple method surveys using computer-assisted telephones interviewing and computer-assisted web interviewing methods. Sample design was intentional...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28984909/impact-of-maternal-vaccination-timing-and-influenza-virus-circulation-on-birth-outcomes-in-rural-nepal
#8
Naoko Kozuki, Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, James M Tielsch
OBJECTIVE: To describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity. METHODS: A secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15-40 years and received a trivalent inactivated influenza vaccine or placebo...
October 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28984736/effect-of-patients-clinical-information-on-the-diagnosis-of-and-decision-to-treat-retinopathy-of-prematurity
#9
Andreas Gschließer, Eva Stifter, Thomas Neumayer, Elisabeth Moser, Andrea Papp, Niklas Pircher, Guido Dorner, Stefan Egger, Nenad Vukojević, Isabel Oberacher-Velten, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the effect of patients' clinical information on experts' diagnoses of retinopathy of prematurity (ROP) and decisions to treat. METHODS: Seven experts assessed wide-field fundus photographs of eyes of 52 premature infants of ≤30 weeks' gestational age or ≤1,500 g birthweight (BW) for ROP diagnosis (stage, plus disease, and aggressive posterior ROP) and the necessity for treatment for 2 days. On Day 1, they were masked to all patient data...
October 3, 2017: Retina
https://www.readbyqxmd.com/read/28984722/safety-and-efficacy-of-micafungin-in-extremely-low-birthweight-infants
#10
Simone S Schüller, Carina Bauer, Lukas Unterasinger, Angelika Berger
Little is known about side effects of micafungin in extremely low birthweight (ELBW) infants. In a retrospective single center study 19 ELBW infants were analyzed for micafungin efficacy and safety. At a mean±SD daily dosage of 7.5 ± 2.0mg/kg no clinically relevant side effects were observed. A significant increase of liver enzymes was reversible after treatment.
September 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28984372/adverse-maternal-and-birth-outcomes-in-women-admitted-to-hospital-for-hyperemesis-gravidarum-a-population-based-cohort-study
#11
Linda Fiaschi, Catherine Nelson-Piercy, Jack Gibson, Lisa Szatkowski, Laila J Tata
BACKGROUND: Evidence for risks of adverse maternal and birth outcomes in women with hyperemesis gravidarum (HG) is predominantly from small studies, unknown, or conflicting. METHODS: A population-based cohort study using secondary health care records (Hospital Episode Statistics covering all of England from 1997 to 2012) was used to calculate odds ratios (OR) with 99% confidence intervals (CI) for the association between HG hospital admission and adverse outcomes, adjusting for maternal and pregnancy confounders...
October 6, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28982731/studies-in-genetically-modified-mice-implicate-maternal-hdl-as-a-mediator-of-fetal-growth
#12
Sandra L Rebholz, John T Melchior, W Sean Davidson, Helen N Jones, Jeffrey A Welge, Andrew M Prentice, Sophie E Moore, Laura A Woollett
Studies in humans have shown a direct association between maternal plasma cholesterol concentrations and infant birthweight. Similarly, previous studies in our laboratory have shown that chow-fed mice lacking apolipoprotein (apo) A-I, the major protein in HDL, have low HDL-cholesterol (HDL-C) concentrations and smaller fetuses in midgestation. In the current study, we measured fetal weights in mice with varying levels of apoA-I gene dose (knockout, wild-type, and transgenic) and examined metabolic pathways known to affect fetal growth...
October 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28967677/the-association-of-health-reform-and-infant-health-evidence-from-massachusetts
#13
Michel H Boudreaux, Rada K Dagher, Scott A Lorch
OBJECTIVE: To estimate whether the incidence of low birthweight and rates of infant mortality were associated with Massachusetts health reform in the overall population and for subgroups that are at higher risk for poor health outcomes. DATA SOURCES: Individual-level data on birthweight were obtained from the National Center for Health Statistics detailed natality files, and aggregated county-level mortality rates were generated from linked birth-death files. We used restricted versions of each file that had intact state and substate geographic identifiers...
October 2, 2017: Health Services Research
https://www.readbyqxmd.com/read/28967080/new-pediatric-risk-factors-for-amblyopia-strabismic-versus-refractive
#14
Sandra Guimaraes, Maria Vieira, Tatiana Queirós, Andreia Soares, Patrício Costa, Eduardo Silva
PURPOSE: To assess the role of risk factors for amblyopia, such as family history and neonatal background, for the prediction of either strabismic amblyopia or refractive amblyopia. METHODS: In this retrospective case-control model, the study population included all children born at the Hospital de Braga during 1997-2012 (3 to 18 years old) with ophthalmologic consultation in 2014. Data collection was performed from the clinical database and through telephone questionnaire surveys...
September 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28962649/adolescent-deliveries-in-rural-cameroon-an-8-year-trend-prevalence-and-adverse-maternofoetal-outcomes
#15
Valirie Ndip Agbor, Clarence Mvalo Mbanga, Tsi Njim
BACKGROUND: Adolescent deliveries remain a global public health concern especially in low- and middle-income countries where 95% of these deliveries occur. In Cameroon, adolescent pregnancies have a high disease burden due to their association with adverse pregnancy outcomes. We sought to evaluate the prevalence, trend and adverse maternofoetal outcomes of adolescent deliveries in a rural community in Cameroon. METHOD: We carried out a retrospective register analysis of 1803 singleton deliveries in two health facilities located in the Oku sub-division over an 8-year period (2009 to 2016)...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28962616/statistical-prediction-of-immunity-to-placental-malaria-based-on-multi-assay-antibody-data-for-malarial-antigens
#16
Chathura Siriwardhana, Rui Fang, Ali Salanti, Rose G F Leke, Naveen Bobbili, Diane Wallace Taylor, John J Chen
BACKGROUND: Plasmodium falciparum infections are especially severe in pregnant women because infected erythrocytes (IE) express VAR2CSA, a ligand that binds to placental trophoblasts, causing IE to accumulate in the placenta. Resulting inflammation and pathology increases a woman's risk of anemia, miscarriage, premature deliveries, and having low birthweight (LBW) babies. Antibodies (Ab) to VAR2CSA reduce placental parasitaemia and improve pregnancy outcomes. Currently, no single assay is able to predict if a woman has adequate immunity to prevent placental malaria (PM)...
September 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28960594/birthweight-hiv-exposure-and-infant-feeding-as-predictors-of-malnutrition-in-botswanan-infants
#17
P Chalashika, C Essex, D Mellor, J A Swift, S Langley-Evans
BACKGROUND: A better understanding of the nutritional status of infants who are HIV-Exposed-Uninfected (HEU) and HIV-Unexposed-Uninfected (HUU) during their first 1000 days is key to improving population health, particularly in sub-Saharan Africa. METHODS: A cross-sectional study compared the nutritional status, feeding practices and determinants of nutritional status of HEU and HUU infants residing in representative selected districts in Botswana during their first 1000 days of life...
September 28, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28960558/reference-values-for-serum-cystatin-c-in-very-low-birthweight-infants-from-two-centres-of-china
#18
Yang Yang, Shu-Jun Li, Jing-Jing Pan, Yu-Hua Hu, Xiao-Yu Zhou, Rui Cheng, Xiao-Qing Chen
AIM: To determine the level of cystatin C (Cys-C) values in preterm babies for the purpose of becoming a good endogenous marker of renal function. METHODS: A total of 366 very low-birthweight infants (including 70 extremely low-birthweight babies) with gestational age <37 weeks born in two centres were studied. RESULTS: In very low-birthweight infants, the mean level of Cys-C was 1.96 ± 0.44 mg/L in blood samples taken on day 1, 1...
September 28, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28957424/nutrition-after-preterm-birth-and-adult-neurocognitive-outcomes
#19
Sara Sammallahti, Eero Kajantie, Hanna-Maria Matinolli, Riikka Pyhälä, Jari Lahti, Kati Heinonen, Marius Lahti, Anu-Katriina Pesonen, Johan G Eriksson, Petteri Hovi, Anna-Liisa Järvenpää, Sture Andersson, Katri Raikkonen
BACKGROUND: Preterm birth (<37 gestational weeks) poses a risk of poorer neurocognitive functioning. Faster growth after preterm birth predicts better cognitive abilities and can be promoted through adequate nutrition, but it remains unknown whether variations in nutrient intakes translate into long-term benefits for neurodevelopment. METHODS: In 86 participants of the Helsinki Study of Very Low Birth Weight Adults (birthweight <1500g), we examined if higher intakes of energy, macronutrients, and human milk during the first nine weeks after preterm birth predict performance in tests of cognitive ability at 25...
2017: PloS One
https://www.readbyqxmd.com/read/28955426/maternal-biomass-smoke-exposure-and-birth-weight-in-malawi-analysis-of-data-from-the-2010-malawi-demographic-and-health-survey
#20
Edith B Milanzi, Ndifanji M Namacha
BACKGROUND: Use of biomass fuels has been shown to contribute to ill health and complications in pregnancy outcomes such as low birthweight, neonatal deaths and mortality in developing countries. However, there is insufficient evidence of this association in the Sub-Saharan Africa and the Malawian population. We, therefore, investigated effects of exposure to biomass fuels on reduced birth weight in the Malawian population. METHODS: We conducted a cross-sectional analysis using secondary data from the 2010 Malawi Demographic Health Survey with a total of 9124 respondents...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
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