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https://www.readbyqxmd.com/read/29244115/atazanavir-and-darunavir-in-pregnant-women-with-hiv-evaluation-of-laboratory-and-clinical-outcomes-from-an-observational-national-study
#1
M Floridia, G Masuelli, M Ravizza, B Tassis, I Cetin, M Sansone, A Degli Antoni, G Simonazzi, A Maccabruni, D Francisci, V Frisina, G Liuzzi, S Dalzero, E Tamburrini
Background: Atazanavir and darunavir represent the main HIV PIs recommended in pregnancy, but comparative data in pregnant women are limited. We assessed the safety and activity profile of these two drugs in pregnancy using data from a national observational study. Methods: Women with atazanavir or darunavir exposure in pregnancy were evaluated for laboratory measures and main pregnancy outcomes (e.g. preterm delivery, low birthweight, non-elective caesarean section and neonatal gestational age-adjusted birthweight Z-score)...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29239901/prevention-of-hiv-1-transmission-through-breastfeeding-efficacy-and-safety-of-maternal-antiretroviral-therapy-versus-infant-nevirapine-prophylaxis-for-duration-of-breastfeeding-in-hiv-1-infected-women-with-high-cd4-cell-count-impaact-promise-a-randomized-open
#2
Patricia M Flynn, Taha E Taha, Mae Cababasay, Mary Glenn Fowler, Lynne M Mofenson, Maxensia Owor, Susan Fiscus, Lynda Stranix-Chibanda, Anna Coutsoudis, Devasena Gnanashanmugam, Nahida Chakhtoura, Katie McCarthy, Cornelius Mukuzunga, Bonus Makanani, Dhayendre Moodley, Teacler Nematadzira, Bangini Kusakara, Sandesh Patil, Tichaona Vhembo, Raziya Bobat, Blandina T Mmbaga, Maysseb Masenya, Mandisa Nyati, Gerhard Theron, Helen Mulenga, Kevin Butler, David E Shapiro
BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in sub-Saharan Africa and India. METHODS: A randomized, open label strategy trial was conducted in HIV-1-infected women with CD4 counts >350 cells/mm (or >country-specific ART threshold if higher) and their breastfeeding HIV-1-uninfected newborns...
December 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29227900/exposures-to-fine-particulate-matter-pm2-5-and-birthweight-in-a-rural-urban-mother-child-cohort-in-tamil-nadu-india
#3
Kalpana Balakrishnan, Santu Ghosh, Gurusamy Thangavel, Sankar Sambandam, Krishnendu Mukhopadhyay, Naveen Puttaswamy, Arulselvan Sadasivam, Padmavathi Ramaswamy, Priscilla Johnson, Rajarajeswari Kuppuswamy, Durairaj Natesan, Uma Maheshwari, Amudha Natarajan, Gayathri Rajendran, Rengaraj Ramasami, Sathish Madhav, Saraswathy Manivannan, Srinivasan Nargunanadan, Srinivasan Natarajan, Sudhakar Saidam, Moumita Chakraborty, Lingeswari Balakrishnan, Vijayalakshmi Thanasekaraan
BACKGROUND: Exposure to PM2.5 (fine particulate matter <less than 2.5µm in aerodynamic diameter) related to ambient and household air pollution has been associated with low birthweight. Few of these studies, however, have been conducted in high exposure settings that are commonly encountered in low and middle income countries (LMICs). OBJECTIVES: We examined whether PM2.5 exposures during pregnancy were associated with birthweight in an integrated rural-urban, mother-child cohort in the state of Tamil Nadu, India...
December 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/29218490/fathers-count-the-impact-of-paternal-risk-factors-on-birth-outcomes
#4
Ying Meng, Susan W Groth
Objective To determine the contribution of paternal factors to the risk of adverse birth outcomes. Methods This is a retrospective cross-sectional analysis using birth certificate data from 2004 to 2015 retrieved from the Finger Lakes Regional Perinatal Data System. Primiparous women with singleton pregnancies were analyzed in the study. Two multivariate logistic regression models were conducted to assess potential paternal risk factors including age, race/ethnicity, and education on four birth outcomes, including preterm birth (PTB), low birthweight (LBW), high birthweight (HBW), and small for gestational age (SGA)...
December 7, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29215314/prenatal-perceived-stress-and-adverse-birth-outcomes-among-puerto-rican-women
#5
Kathleen Szegda, Elizabeth R Bertone-Johnson, Penelope Pekow, Sally Powers, Glenn Markenson, Nancy Dole, Lisa Chasan-Taber
BACKGROUND: Preterm birth and low birthweight contribute substantially to the disproportionately high infant mortality rates experienced by Puerto Ricans in the United States. The purpose of this study was to examine whether the timing and pattern of prenatal psychosocial stress increased risk of adverse birth outcomes in this high-risk population. MATERIALS AND METHODS: Proyecto Buena Salud was a prospective cohort study conducted from 2006 to 2011 among predominantly Puerto Rican women...
December 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29212820/vision-in-former-very-low-birthweight-young-adults-with-and-without-retinopathy-of-prematurity-compared-with-term-born-controls-the-nz-1986-vlbw-follow-up-study
#6
Brian A Darlow, Mark J Elder, Bridget Kimber, Julia Martin, L John Horwood
OBJECTIVE: There are few data on visual outcomes in adulthood of former very low birthweight (VLBW; <1500 g) infants. We aimed to assess vision at 27-29 years in a national cohort of VLBW infants born in 1986 and assessed for retinopathy of prematurity (ROP) when no treatment was available, compared with term born controls. METHODS: The cohort and controls attended a 2-day assessment in Christchurch as part of a larger study. Visual assessment included glasses prescription measured by focimeter, logarithm of the minimum angle of resolution (logMAR) distance visual acuity (VA), contrast sensitivity, autorefraction, retinal photographs and a questionnaire on vision-related everyday activities...
December 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29212432/maternity-leave-duration-and-adverse-pregnancy-outcomes-an-international-country-level-comparison
#7
Emma Kwegyir-Afful, George Adu, Evelien R Spelten, Kimmo Räsänen, Jos Verbeek
AIM: Preterm birth and low birthweight (LBW) lead to infant morbidity and mortality. The causes are unknown. This study evaluates the association between duration of maternity leave and birth outcomes at country level. METHOD: We compiled data on duration of maternity leave for 180 countries of which 36 specified prenatal leave, 190 specified income, 183 specified preterm birth rates and 185 specified the LBW rate. Multivariate and seemingly unrelated regression analyses were done in STATA...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29209598/inflammatory-mediators-in-tracheal-aspirates-of-preterm-infants-participating-in-a-randomized-trial-of-permissive-hypercapnia
#8
Sarah Gentner, Mandy Laube, Ulrike Uhlig, Yang Yang, Hans W Fuchs, Jens Dreyhaupt, Helmut D Hummler, Stefan Uhlig, Ulrich H Thome
Background: Ventilator-induced lung injury is considered to be a main factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Optimizing ventilator strategies may reduce respiratory morbidities in preterm infants. Permissive hypercapnia has been suggested to attenuate lung injury. We aimed to determine if a higher PCO2 target range results in less lung injury compared to the control target range and possibly reduces pro-inflammatory cytokines and acid sphingomyelinase (ASM) in tracheal aspirates (TA), which has not been addressed before...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29208042/abnormal-placental-cord-insertion-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#9
Khadijah Irfah Ismail, Ailish Hannigan, Keelin O'Donoghue, Amanda Cotter
BACKGROUND: Abnormal placental cord insertion (PCI) includes marginal cord insertion (MCI) and velamentous cord insertion (VCI). VCI has been shown to be associated with adverse pregnancy outcomes. This systematic review and meta-analysis aims to determine the association of abnormal PCI and adverse pregnancy outcomes. METHODS: Embase, Medline, CINAHL, Scopus, Web of Science, ClinicalTrials.gov, and Cochrane Databases were searched in December 2016 (from inception to December 2016)...
December 6, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29206936/birthweight-of-singletons-born-after-cleavage-stage-or-blastocyst-transfer-in-fresh-and-warming-cycles
#10
Anick De Vos, Samuel Santos-Ribeiro, Lisbet Van Landuyt, Hilde Van de Velde, Herman Tournaye, Greta Verheyen
STUDY QUESTION: Does extended culture to the blastocyst stage affect singleton birthweight after either fresh or vitrified-warmed embryo transfer? SUMMARY ANSWER: Singleton birthweight z-scores did not vary significantly after a fresh blastocyst transfer, whereas the additional effect of vitrification remains inconclusive. WHAT IS KNOWN ALREADY: Observational studies have associated extended culture with an increased risk of preterm birth and low birthweight...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29204302/parainfluenza-3-respiratory-infection-associated-with-pericardial-effusion-in-a-very-low-birthweight-infant
#11
Cristina Aranda Cazón, Luis Arruza Gómez, Gloria Herranz Carrillo, Cristina González Menchén, Zarife Daoud Pérez, José Antonio Martínez-Orgado, José Tomás Ramos Amador
Parainfluenza 3 virus is a frequent cause of respiratory infections in the pediatric population although it is uncommonly diagnosed in neonates, being usually reported as neonatal intensive care unit microepidemics. We report a case of parainfluenza 3 respiratory infection associated with pericardial effusion in a very low birthweight infant.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29203503/multicentre-prospective-randomised-single-blind-controlled-study-protocol-of-the-effect-of-an-additional-parent-administered-sensorimotor-stimulation-on-neurological-development-of-preterm-infants-primebrain
#12
Karine Pelc, Irit Daniel, Bernard Wenderickx, Bernard Dan
INTRODUCTION: Preterm and very low birthweight infants are at increased risk for neurodevelopmental disorders, including cerebral palsy, sensory impairment and intellectual disability. Several early intervention approaches have been designed in the hope of optimising neurological development in this context. It seems important that the intervention takes into account parental mental health, focuses on parent-child interactions and lasts sufficiently long. This study aims to evaluate the effects of a stimulation programme administered by parents until 6 months post-term on motor and neurophysiological development of infants born preterm...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29198051/doula-services-within-a-healthy-start-program-increasing-access-for-an-underserved-population
#13
Mary-Powel Thomas, Gabriela Ammann, Ellen Brazier, Philip Noyes, Aletha Maybank
PURPOSE: Women of color in the United States, particularly in high-poverty neighborhoods, experience high rates of poor birth outcomes, including cesarean section, preterm birth, low birthweight, and infant mortality. Doula care has been linked to improvements in many perinatal outcomes, but women of color and low-income women often face barriers in accessing doula support. DESCRIPTION: To address this issue, the New York City Department of Health and Mental Hygiene's Healthy Start Brooklyn introduced the By My Side Birth Support Program in 2010...
December 2, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29193118/in-premature-infants-there-is-no-decrease-in-24-hour-posttransfusion-allogeneic-red-blood-cell-recovery-after-42-days-of-storage
#14
Demet Nalbant, José A Cancelas, Donald M Mock, Svetlana V Kyosseva, Robert L Schmidt, Gretchen A Cress, M Bridget Zimmerman, Ronald G Strauss, John A Widness
BACKGROUND: Critically ill preterm very-low-birthweight (VLBW) neonates (birthweight ≤ 1.5 kg) frequently develop anemia that is treated with red blood cell (RBC) transfusions. Although RBCs transfused to adults demonstrate progressive decreases in posttransfusion 24-hour RBC recovery (PTR24 ) during storage-to a mean of approximately 85% of the Food and Drug Administration-allowed 42-day storage-limited data in infants indicate no decrease in PTR24 with storage. STUDY DESIGN AND METHODS: We hypothesized that PTR24 of allogeneic RBCs transfused to anemic VLBW newborns: 1) will be greater than PTR24 of autologous RBCs transfused into healthy adults and 2) will not decrease with increasing storage duration...
November 29, 2017: Transfusion
https://www.readbyqxmd.com/read/29172830/like-mother-like-daughter-low-birthweight-and-preeclampsia-tend-to-reoccur-at-the-next-generation
#15
Y Sherf, E Sheiner, I Shoham Vardi, R Sergienko, J Klein, N Bilenko
BACKGROUND: Low birthweight and preeclampsia are both adverse pregnancy and delivery outcomes, with possible influence on future health status. Previous studies have shown that intergenerational factors may be important prognostic information in evaluating women prior to or after conception. Our objective was to evaluate the role of intergenerational factors on the incidence of preeclampsia and low birthweight (LBW). METHODS: A retrospective population-based study was conducted...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29165697/lifting-and-pregnancy-outcomes-feasibility-of-a-randomized-controlled-trial
#16
E Kwegyir-Afful, J Verbeek, L Aziato, J D Seffah, K Vehviläinen-Julkunen, K Räsänen
Background: The highest incidence of preterm birth (18%) occurs in Africa but the causes are largely unknown. Some studies have reported adverse effects of maternal physical exertion on birth outcomes. A randomized controlled trial (RCT) is proposed to determine the effectiveness of an intervention reducing lifting and carrying in pregnant women in reducing preterm birth and low birthweight. Aims: To test the feasibility and acceptability of the proposed lift-less intervention RCT...
November 19, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29163461/factors-affecting-the-fcrn-mediated-transplacental-transfer-of-antibodies-and-implications-for-vaccination-in-pregnancy
#17
REVIEW
Christopher R Wilcox, Beth Holder, Christine E Jones
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life. Transcytosis of IgG occurs via binding with the neonatal Fc receptor (FcRn) in the placental synctiotrophoblast. As maternal vaccination becomes an increasingly important strategy for the protection of young infants, improving our understanding of transplacental transfer and the factors that may affect this will become increasingly important, especially in low-income countries where the burden of morbidity and mortality is highest...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29159790/vitamin-d-supplementation-in-pregnancy-a-survey-of-compliance-with-recommendations
#18
C M Windrim, D A Crosby, K Mitchell, C Brophy, R Mahony, M Higgins
BACKGROUND: Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pregnancy and lactation. AIMS: This study aimed to determine the prevalence of women taking vitamin D supplementation and to identify the reasons for patients not taking supplementation within women attending an antenatal clinic in Dublin...
November 20, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29157866/vaginal-progesterone-for-preventing-preterm-birth-and-adverse-perinatal-outcomes-in-singleton-gestations-with-a-short-cervix-a-meta-analysis-of-individual-patient-data
#19
Roberto Romero, Agustin Conde-Agudelo, Eduardo Da Fonseca, John M O'Brien, Elcin Cetingoz, George W Creasy, Sonia S Hassan, Kypros H Nicolaides
BACKGROUND: The efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix has been questioned after publication of the OPPTIMUM study. OBJECTIVE: To determine whether vaginal progesterone prevents preterm birth and improves perinatal outcomes in asymptomatic women with a singleton gestation and a midtrimester sonographic short cervix. DATA SOURCES: MEDLINE, EMBASE, LILACS, and CINAHL (from their inception to September 2017), Cochrane databases, bibliographies, and conference proceedings...
November 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29153673/pregnancy-complications-and-later-vascular-ultrasound-measures-a-cohort-study
#20
Emily W Harville, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Olli T Raitakari
OBJECTIVES: Pregnancy complications predict or even predispose to later cardiovascular disease in the mother. We examined whether pregnancy complications are associated with post-pregnancy measures of endothelial dysfunction and arterial stiffness. STUDY DESIGN: Prospective cohort; Data for 847 women female participants in the Cardiovascular Risk in Young Finns study were linked with the national birth registry. Preterm birth (<37weeks), low birthweight (<2500g), small-for-gestational-age (weight <10th percentile for gestational age), and hypertensive disorders of pregnancy were examined as predictors of later vascular measures...
October 2017: Pregnancy Hypertension
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