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Non-secretory MM

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https://www.readbyqxmd.com/read/27932503/computational-modelling-of-epithelial-fluid-and-ion-transport-in-the-parotid-duct-after-transfection-of-human-aquaporin-1
#1
Shelley Fong, John A Chiorini, James Sneyd, Vinod Suresh
Previous studies have shown that localized delivery of the aquaporin-1 (AQP1) gene to the parotid duct can restore saliva flow in minipigs following irradiation-induced salivary hypofunction. The resulting flow rate and electrochemisty of secreted saliva contradicts current understanding of ductal fluid transport. We hypothesized that changes in expression of ion transport proteins have occurred following AQP1 transfection. We use a mathematical model of ion and fluid transport across the parotid duct epithelial cells to predict the expression profile of ion transporters that are consistent with the experimental measurements of saliva composition and secretion rates...
December 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27558258/regulation-by-l-channels-of-ca-2-evoked-secretory-responses-in-ouabain-treated-chromaffin-cells
#2
Ricardo De Pascual, Inés Colmena, Lucía Ruiz-Pascual, Andrés Mateo Baraibar, Javier Egea, Luis Gandía, Antonio G García
It is known that the sustained depolarisation of adrenal medullary bovine chromaffin cells (BCCs) with high K(+) concentrations produces an initial sharp catecholamine release that subsequently fades off in spite depolarisation persists. Here, we have recreated a sustained depolarisation condition of BCCs by treating them with the Na(+)/K(+) ATPase blocker ouabain; in doing so, we searched experimental conditions that permitted the development of a sustained long-term catecholamine release response that could be relevant during prolonged stress...
October 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27440994/glut1-activity-contributes-to-the-impairment-of-pedf-secretion-by-the-rpe
#3
Sofia M Calado, Liliana S Alves, Sónia Simão, Gabriela A Silva
PURPOSE: In this study, we aimed to understand whether glucose transporter 1 (GLUT1) activity affects the secretion capacity of antiangiogenic factor pigment epithelium-derived factor (PEDF) by the RPE cells, thus explaining the reduction in PEDF levels observed in patients with diabetic retinopathy (DR). METHODS: Analysis of GLUT1 expression, localization, and function was performed in vitro in RPE cells (D407) cultured with different glucose concentrations, corresponding to non-diabetic (5 mM of glucose) and diabetic (25 mM of glucose) conditions, further subjected to normoxia or hypoxia...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27285384/honeybees-produce-millimolar-concentrations-of-non-neuronal-acetylcholine-for-breeding-possible-adverse-effects-of-neonicotinoids
#4
Ignaz Wessler, Hedwig-Annabel Gärtner, Rosmarie Michel-Schmidt, Christoph Brochhausen, Luise Schmitz, Laura Anspach, Bernd Grünewald, Charles James Kirkpatrick
The worldwide use of neonicotinoid pesticides has caused concern on account of their involvement in the decline of bee populations, which are key pollinators in most ecosystems. Here we describe a role of non-neuronal acetylcholine (ACh) for breeding of Apis mellifera carnica and a so far unknown effect of neonicotinoids on non-target insects. Royal jelly or larval food are produced by the hypopharyngeal gland of nursing bees and contain unusually high ACh concentrations (4-8 mM). ACh is extremely well conserved in royal jelly or brood food because of the acidic pH of 4...
2016: PloS One
https://www.readbyqxmd.com/read/27221891/international-scoring-system-in-symptomatic-multiple-myeloma-experience-from-a-tertiary-care-center
#5
Sadia Sultan, Syed Mohammed Irfan, Saira Parveen, Ufaq Taufiq
BACKGROUND: Symptomatic multiple myeloma (MM) is an acquired B-cell malignant proliferation of anti- body secreting plasma cells, characterized by end organ damage due to monoclonal immunoglobulin secretion. The aim of this study wa to determine the stage stratification according to an international scoring system in adult Pakistani MM patients at presentation. MATERIALS AND METHODS: This single centre retrospective study extendedfrom January 2012 to December 2015...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27114695/ulcer-protective-activity-of-jatropha-gossypiifolia-linn-in-wistar-rats
#6
Arumugam Ramamoorthy Vijayakumar, Epison Prabu Daniel, Raju Ilavarasan, S Venkataraman, S Vijayakumar
BACKGROUND: Several synthetic drugs are useful in the treatment of peptic ulcer, but almost of these drugs are used in prolonging time, it may cause several adverse reactions. However, the herbal medicines are more potent to the treatment and minimize the side effects. OBJECTIVE: To evaluate the methanol extract of Jatropha gossypiifolia Linn. (MEJG) for gastro protective activity against Wistar rats. MATERIALS AND METHODS: Anti-ulcer potency of MEJG (100 and 200 mg/kg, b...
March 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/26875957/pleural-effusion-in-multiple-myeloma
#7
Zhuo Wang, Guoguang Xia, Ling Lan, Fayong Liu, Yanxun Wang, Baoyue Liu, Yi Ding, Li Dai, Yunjian Zhang
OBJECTIVE: Pleural effusion is rarely observed in patients with multiple myeloma (MM). Myeloma cell infiltration or invasion to the pleura is very rare. This study aimed to investigate the clinical characteristics of pleural effusion in patients with MM. METHODS: We retrospectively reviewed the medical records of patients diagnosed with pleural effusion, MM, and pleural effusion with MM between 2004 and 2014 at Beijing Jishuitan Hospital. The present study included patients with pleural effusion who underwent cytological, bacteriological, biochemical and other testing...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26528383/non-secretory-multiple-myeloma-with-extensive-extramedullary-plasmacytoma-a-diagnostic-dilemma
#8
Soo Fin Low, Nor Hanani Mohd Tap, Thean Yean Kew, Chai Soon Ngiu, Radhika Sridharan
Multiple myeloma (MM) is characterized by progressive proliferation of malignant plasma cells, usually initiating in the bone marrow. MM can affect any organ; a total of 7 - 18% of patients with MM demonstrate extramedullary involvement at diagnosis. Non-secretory multiple myeloma (NSMM) is a rare variant that accounts for 1 - 5% of all cases of multiple myeloma. The disease is characterized by the absence of monoclonal gammopathy in serum and urine electrophoresis. Our case report highlights the diagnostic challenge of a case of NSMM with extensive extramedullary involvement in a young female patient who initially presented with right shoulder pain and bilateral breasts lumps...
July 2015: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/26324089/incretin-hormones-and-maturity-onset-diabetes-of-the-young-pathophysiological-implications-and-anti-diabetic-treatment-potential
#9
RANDOMIZED CONTROLLED TRIAL
Signe Harring Østoft
Maturity onset diabetes of the young (MODY) designates monogenic forms of non-autoimmune diabetes characterised by autosomal dominant inheritance, non-insulin dependent diabetes at onset and diagnosis often before 25 years of age. MODY constitutes genetically and clinically heterogeneous forms of diabetes. More than 8 different genes are known to cause MODY, among which hepatocyte nuclear factor 1 alpha (HNF1A) (MODY3) and glucokinase (GCK) (MODY2) mutations are the most common. Both forms of MODY are characterised by specific beta cell dysfunction, with patients with HNF1A-diabetes having a reduced insulin secretory capacity, while patients with GCK-diabetes have a glucose-sensing defect, but preserved insulin secretory capacity...
September 2015: Danish Medical Journal
https://www.readbyqxmd.com/read/26135640/sexual-maturation-and-changes-in-water-and-salt-transport-components-in-the-kidney-and-intestine-of-three-spined-stickleback-gasterosteus-aculeatus-l
#10
Steffen S Madsen, Claus Weber, Andreas M Nielsen, Mohammad Mohiseni, Maryline C Bosssus, Christian K Tipsmark, Bertil Borg
Mature three-spined stickleback males use spiggin threads secreted from their kidney to glue together nest material. This requires strongly hypertrophied renal proximal tubular cells, which compromises renal osmoregulatory function during the breeding period. Experimental evidence suggests that the intestine takes over hypotonic fluid secretion at that stage but the mechanism is unexplored. To unravel the molecular mechanism we analyzed and compared transcript levels of several membrane proteins involved in water and salt transport in intestinal and renal tissues, in non-mature males (NM), mature males (MM), and mature females (MF)...
October 2015: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/26108343/high-expression-of-endoplasmic-reticulum-chaperone-grp94-is-a-novel-molecular-hallmark-of-malignant-plasma-cells-in-multiple-myeloma
#11
Saurabh Chhabra, Sandeep Jain, Caroline Wallace, Feng Hong, Bei Liu
BACKGROUND: Multiple myeloma (MM) is a hematologic malignancy that is characterized by the proliferation of abnormal bone marrow plasma cells (BMPC) and overproduction of immunoglobulin or light chains with evidence of end-organ damage such as bone damage, anemia, hypercalcemia, and renal dysfunction. The pathogenesis of MM is closely linked to dysregulated unfolded protein response (UPR) in the endoplasmic reticulum (ER). Constitutive activation of UPR in mice, as demonstrated by transgenic expression of a master UPR transcription factor XBP1s (a UPR-specific splice variant of X-box binding protein 1), causes myeloma...
2015: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/26021997/bisphenol-a-modulates-receptivity-and-secretory-function-of-human-decidual-cells-an-in-vitro-study
#12
Chiara Mannelli, Anna Z Szóstek, Karolina Lukasik, Claudiopietro Carotenuto, Francesca Ietta, Roberta Romagnoli, Cristina Ferretti, Luana Paulesu, Slawomir Wołczynski, Dariusz Jan Skarzynski
The human endometrium is a fertility-determining tissue and a target of steroid hormones' action. Endocrine disruptors (EDs) can exert adverse effects on the physiological function of the decidua at the maternal-fetal interface. We examined the potential effects of an ED, bisphenol A (BPA), on endometrial maturation/decidualization, receptivity, and secretion of decidual factors (biomarkers). In vitro decidualized, endometrial stromal cells from six hysterectomy specimens were treated with 1  pM-1  μM of BPA, for 24  h and assessed for cell viability and proliferation...
August 2015: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/25736590/dual-modal-magnetic-resonance-fluorescent-zinc-probes-for-pancreatic-%C3%AE-cell-mass-imaging
#13
Graeme J Stasiuk, Florencia Minuzzi, Myra Sae-Heng, Charlotte Rivas, Hans-Paul Juretschke, Lorenzo Piemonti, Peter R Allegrini, Didier Laurent, Andrew R Duckworth, Andrew Beeby, Guy A Rutter, Nicholas J Long
Despite the contribution of changes in pancreatic β-cell mass to the development of all forms of diabetes mellitus, few robust approaches currently exist to monitor these changes prospectively in vivo. Although magnetic-resonance imaging (MRI) provides a potentially useful technique, targeting MRI-active probes to the β cell has proved challenging. Zinc ions are highly concentrated in the secretory granule, but they are relatively less abundant in the exocrine pancreas and in other tissues. We have therefore developed functional dual-modal probes based on transition-metal chelates capable of binding zinc...
March 23, 2015: Chemistry: a European Journal
https://www.readbyqxmd.com/read/25367417/purification-and-characterization-of-secretory-serine-protease-from-necrotrophic-oomycete-pythium-myriotylum-dreschler
#14
Ravindranathan Aswati Nair, Chellappan Geethu
Progressive increase in extracellular proteolytic activity with respect to growth was detected in cultures of necrotrophic oomycete Pythium myriotylum Dreschler with maximum activity detected at stationary phase of growth. The secretory protease from P. myriotylum designated, spPm1 was purified to homogeneity giving a single band of 47 kDa molecular mass on non-reducing SDS-PAGE and exhibiting caseinolytic activity in the zymogram. Under reducing conditions, an additional band of 27.0 kDa molecular size observed was subjected to matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) analysis...
January 2015: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/25218739/%C3%A2-%C3%A2-f-fdg-pet-ct-a-review-of-diagnostic-and-prognostic-features-in-multiple-myeloma-and-related-disorders
#15
REVIEW
Franco Dammacco, Giuseppe Rubini, Cristina Ferrari, Angelo Vacca, Vito Racanelli
Conventional radiographic skeletal survey has been for many years the gold standard to detect the occurrence of osteolytic lesions in patients with multiple myeloma (MM). However, the introduction of more sensitive imaging procedures has resulted in an updated anatomic and functional Durie and Salmon "plus" staging system and has remarkably changed the diagnostic and prognostic approach to this tumor. It is now established that (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron-emission tomography (PET) combined with low-dose computed tomography (CT), shortly designated PET/CT, exhibits a higher screening and diagnostic sensitivity and specificity over the skeleton X-ray...
February 2015: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25158178/correlation-of-ameloblastin-with-enamel-mineral-content
#16
John D Teepe, James E Schmitz, Yuanyuan Hu, Yoshihiko Yamada, Roberto J Fajardo, Charles E Smith, Yong-Hee P Chun
In enamel formation, the deposition of minerals as crystallites starts when the mineralization front first forms at the start of the secretory stage. During maturation, the enamel layer accumulates significant amounts of new mineral as the crystallites grow in volume. Inversely related to mineral gain is loss of protein and water from the forming enamel. Both ameloblastin (Ambn) and enamelin are essential components for formation of a functional enamel layer. The aim of this study was to quantify the proportion of mineral and non-mineral material present in developing enamel relative to Ambn concentration using Ambn mutant mice mated with others overexpressing full-length Ambn from the mouse amelogenin promoter at lower (+), similar (++) or higher (+++) concentration than normal...
August 2014: Connective Tissue Research
https://www.readbyqxmd.com/read/24930515/inhibition-of-phosphodiesterase-3b-in-insulin-secreting-cells-of-normal-and-streptozocin-nicotinamide-induced-diabetic-rats-implications-for-insulin-secretion
#17
A Zywert, K Szkudelska, T Szkudelski
Cyclic adenosine monophosphate (cAMP) plays important role in the potentiation of insulin secretion in pancreatic B-cells. However, the relevance of cAMP-degrading enzymes in the regulation of insulin secretion is not fully elucidated. The present work was undertaken to determine effects of inhibition of phosphodiesterase 3B (PDE3B) by amrinone on insulin secretion from pancreatic islets and perfused pancreas of normal and mildly diabetic rats. Inhibition of this enzyme was demonstrated to substantially increase insulin-secretory response to 6...
June 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/24704640/hexosamine-pathway-but-not-interstitial-changes-mediates-glucotoxicity-in-pancreatic-%C3%AE-cells-as-assessed-by-cytosolic-ca2-response-to-glucose
#18
Kazuhiro Yanagida, Yuko Maejima, Putra Santoso, Zesemdorj Otgon-Uul, Yifei Yang, Kazuya Sakuma, Kenju Shimomura, Toshihiko Yada
Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions around β-cells, including elevated osmolarity and increased concentrations of insulin and ATP released from overstimulated β-cells. In this study, to explore direct effects of these alterations on β-cells, single β-cells isolated from rat islets were cultured for 3 days with high (22...
March 2014: Aging
https://www.readbyqxmd.com/read/24489083/serum-free-light-chain-assay-clinical-utility-and-limitations
#19
REVIEW
Malini V Bhole, Ross Sadler, Karthik Ramasamy
In the last decade, the introduction of the serum-free light-chain (sFLC) assay has been an important advance in the diagnosis and management of plasma cell dyscrasias, particularly monoclonal light-chain diseases. The immunoassay was developed to detect free light chains in serum by using anti-FLC antibodies which specifically recognised epitopes on light chains that were 'hidden' in intact immunoglobulins. Since its introduction in 2001, there have been several publications in the English language literature discussing the clinical utility as well as analytical limitations of the sFLC assay...
September 2014: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/23916837/augmenter-of-liver-regeneration-a-protective-factor-against-ros-induced-oxidative-damage-in-muscle-tissue-of-mitochondrial-myopathy-affected-patients
#20
Lorenzo Polimeno, Roberta Rossi, Maria Mastrodonato, Monica Montagnani, Domenico Piscitelli, Barbara Pesetti, Leonarda De Benedictis, Bruna Girardi, Leonardo Resta, Anna Napoli, Antonio Francavilla
Mitochondria-related myopathies (MM) are a group of different diseases defined by a varying degree of dysfunctions of the mitochondrial respiratory chain which leads to reactive oxygen species (ROS) generation followed by oxidative stress and cellular damage. In mitochondrial myopathy muscle tissue an overexpression of antioxidant enzymes has been documented probably as an attempt to counteract the free radical generation. We previously documented, in human non-pathological muscle fibres, the expression of the augmenter of liver regeneration (ALR), a sulfhydryl oxidase enzyme, whose presence is related to the mitochondria; indeed it has been demonstrated that ALR mainly localizes in the mitochondrial inter-membrane space...
November 2013: International Journal of Biochemistry & Cell Biology
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