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https://www.readbyqxmd.com/read/29163970/effect-of-low-dose-aspirin-use-on-pancreatic-cancer-development-and-morphological-changes-on-imaging-in-ipmn-a-long-term-cohort-study
#1
Yusuke Takasaki, Naoyoshi Nagata, Koh Imbe, Yuya Hisada, Katsunori Sekine, Tsuyoshi Tajima, Mikio Yanase, Kazuma Fujimoto, Junichi Akiyama, Naomi Uemura
Background: Aspirin use may reduce the incidence of pancreatic cancer (PC), but no data are available regarding its chemopreventive effects on intraductal papillary mucinous neoplasm (IPMN). We aimed to determine whether low-dose aspirin (LDA) reduces PC development and morphological changes on imaging in IPMN patients. Methods: A cohort of 448 IPMN patients periodically followed up with imaging tests was analyzed. We used one-to-two propensity score matching to adjust for differences between an LDA group (n = 63) and a non-LDA group (n = 385)...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29145338/pancreatogenic-choledocholithiasis-in-common-bile-duct-stump-after-roux-en-y-hepaticojejunostomy-a-case-report
#2
Yuan-Hui Jiang, An-Hong Zhang, Shao-Jun Zhou
RATIONALE: Choledocholithiasis in common bile duct (CBD) stump after Roux-en-Y hepaticojejunostomy (RYHJ) is incredibly rare and its pathophysiology is poorly understood. PATIENT CONCERNS: A 79-year-old woman was admitted to our hospital with upper abdominal pain radiating through to the back in November 2016. DIAGNOSES: Abdominal computed tomography (CT) scan and magnetic resonance cholangiopancreatography (MRCP) revealed filling defects in CBD stump, chronic pancreatitis, and dilatation of CBD stump and main pancreatic duct (MPD)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143464/mean-platelet-diameter-measurements-to-classify-inherited-thrombocytopenias
#3
K Fixter, D J Rabbolini, B Valecha, M-C Morel-Kopp, S Gabrielli, Q Chen, W S Stevenson, C M Ward
INTRODUCTION: Mean platelet volume (MPV) assists the differential diagnosis of inherited thrombocytopenia (IT) but lacks standardisation and varies between automated analysers. Classification of IT based on mean platelet diameter (MPD) has been proposed by an international collaborative study but has not been validated. METHODS: To assess the applicability of MPD to classify forms of IT, digital images of blood films from patients with established genetic causes for IT were generated, and the MPD measured (ZEISS Axio-scanner and Image J software) by a blinded reviewer...
November 16, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29136208/mouse-phenome-database-an-integrative-database-and-analysis-suite-for-curated-empirical-phenotype-data-from-laboratory-mice
#4
Molly A Bogue, Stephen C Grubb, David O Walton, Vivek M Philip, Georgi Kolishovski, Tim Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29111650/surface-engineering-of-thin-film-composite-polyamide-membranes-with-silver-nanoparticles-through-layer-by-layer-interfacial-polymerization-for-antibacterial-properties
#5
Zhongyun Liu, Longbin Qi, Xiaochan An, Caifeng Liu, Yunxia Hu
We developed a simple and facile approach to covalently immobilize Ag nanoparticles (NPs) onto polyamide surfaces of thin film composite membranes through layer-by-layer interfacial polymerization (LBL-IP) for biofouling mitigation. Stable and uniform bovine serum albumin (BSA) capped Ag NPs with an average diameter of around 20 nm were synthesized using BSA as a template under the assistance of sonication, and Ag NPs incorporated thin film composite (TFC) polyamide membrane was then fabricated by LBL-IP on a nanoporous polysulfone (PSf) substrate upon sequential coating with m-phenylenediamine (MPD) aqueous solution, trimesoyl chloride (TMC)-hexane solution, and finally BSA-capped Ag NPs aqueous solution...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29097239/studies-on-the-environmental-fate-ecotoxicology-and-toxicology-of-2-methyl-1-3-propanediol
#6
REVIEW
J Fowles, C Lewis, E Rushton
2-methyl 1,3-propandiol (MPD) is a low molecular weight, colorless glycol used in polymer and coating applications. The log Kow of -0.6 suggests partitioning to aqueous phases with a low concern for possible bioaccumulation. MPD was found to be inherently biodegradable. Ecotoxicological results in several aquatic and terrestrial species found no significant hazard potential. MPD is rapidly absorbed via the oral and dermal routes, metabolized to 3-hydroxybutyrate, and excreted in urine with a half-life of 3...
October 28, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29094932/preparation-of-an-efficient-ratiometric-fluorescent-nanoprobe-m-cds-ru-bpy-3-2-for-visual-and-specific-detection-of-hypochlorite-on-site-and-in-living-cells
#7
Yuanjin Zhan, Fang Luo, Longhua Guo, Bin Qiu, Yuhong Lin, Juan Li, Guonan Chen, Zhenyu Lin
Hypochlorite (ClO(-)) is one of the most important reactive oxygen species (ROS), which plays an important role in sustaining human innate immunity during microbial invasion. Moreover, ClO(-) is a powerful oxidizer for water treatment. The safety of drinking water is closely related to its content. Herein, m-phenylenediamine (mPD) is used as a precursor to prepare carbon dots (named m-CDs) with highly fluorescent quantum yield (31.58% in water), and our investigation shows that the strong fluorescent emission of m-CDs can be effectively quenched by ClO(-)...
November 9, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29090586/diagnosis-and-treatment-of-myh9-rd-in-an-australasian-cohort-with-thrombocytopenia
#8
David J Rabbolini, Yenna Chun, Maya Latimer, Shinji Kunishima, Kathleen Fixter, Bhavia Valecha, Peter Tan, Lee Ping Chew, Benjamin T Kile, Rachel Burt, Kottayam Radhakrishnan, Robert Bird, Paul Ockelford, Sara Gabrielli, Qiang Chen, William S Stevenson, Christopher M Ward, Marie-Christine Morel-Kopp
MYH9-related disorders (MYH9-RDs) caused by mutation of the MYH9 gene which encodes non-muscle myosin heavy-chain-IIA (NMMHC-IIA), an important motor protein in hemopoietic cells, are the most commonly encountered cause of inherited macrothrombocytopenia. Despite distinguishing features including an autosomal dominant mode of inheritance, giant platelets on the peripheral blood film accompanied by leucocytes with cytoplasmic inclusion bodies (döhle-like bodies), these disorders remain generally under-recognized and often misdiagnosed as immune thrombocytopenia (ITP)...
November 1, 2017: Platelets
https://www.readbyqxmd.com/read/29082243/mammary-and-extramammary-paget-s-disease-presented-different-expression-pattern-of-steroid-hormone-receptors
#9
Songxia Zhou, Weixiang Zhong, Ruiqin Mai, Guohong Zhang
BACKGROUND AND OBJECTIVES: Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD. METHODS: Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. RESULTS: Positive expression of AR was significantly higher in EMPD (61...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29023679/explaining-ecosystem-multifunction-with-evolutionary-models
#10
Marc W Cadotte, Stuart W Livingstone, Simone-Louise E Yasui, Russell Dinnage, Jin-Tian Li, Robin Marushia, James Santangelo, Wensheng Shu
Ecosystem function is the outcome of species interactions, traits, and niche overlap -all of which are influenced by evolution. However, it is not well understood how the tempo and mode of niche evolution can influence ecosystem function. In evolutionary models where either species differences accumulate through random drift in a single trait or species differences accumulate through divergent selection among close relatives, we should expect that ecosystem function is strongly related to diversity. However, when strong selection causes species to converge on specific niches or when novel traits that directly affect function evolve in some clades but not others, the relationship between diversity and ecosystem function might not be very strong...
October 11, 2017: Ecology
https://www.readbyqxmd.com/read/29023105/specific-detection-of-carcinoembryonic-antigen-based-on-fluorescence-quenching-of-hollow-porous-gold-nanoshells-with-roughened-surface
#11
Ting-Yang Xing, Jing Zhao, Guo-Jun Weng, Jian Zhu, Jian-Jun Li, Jun-Wu Zhao
The detection of tumor biomarkers in the early stage is highly desirable for the therapy of cancer. However, rapid, low-cost, sensitive, and selective detection of biomarkers remains a challenge owing to the sequence homology, short length, and low abundance. This Research Article describes the synthesis of a novel carcinoembryonic antigen (CEA) probe using hollow porous gold nanoparticles (HPGNPs) with roughened surface based on fluorescence quenching. For specific detection of CEA, the surface of HPGNP is modified by carboxyl modification, carboxyl activation, and antibody conjugation...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28991803/enhanced-flux-performance-of-polyamide-composite-membranes-prepared-via-interfacial-polymerization-assisted-with-ethyl-formate
#12
Zhaofeng Liu, Guiru Zhu, Yulin Wei, Dapeng Zhang, Lei Jiang, Haizeng Wang, Congjie Gao
A novel thin film composite (TFC) polyamide reverse osmosis membrane was prepared via the interfacial polymerization of m-phenylene diamine (MPD) in aqueous phase and 1,3,5-trimesoyl chloride (TMC) in organic phase on a polysulfone ultrafiltration support by assisting with ethyl formate as a co-solvent added in the organic phase. The ethyl formate added in the organic phase is intended to form a narrow miscibility zone, which leads to the thicker reaction zone. The multi-layered loose polyamide structure with larger pore size was formed due to the thicker reaction zone and lower content of MPD...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28990381/enucleation-of-non-invasive-tumors-in-the-proximal-pancreas-indications-and-outcomes-compared-with-standard-resections
#13
Wen-Jie Lu, Hao-Lei Cai, Ma-Dong Ye, Yu-Lian Wu, Bin Xu
OBJECTIVE: The aim of this study was to evaluate the safety and efficiency of enucleation (EU) for proximal pancreatic non-invasive neoplasms. METHODS: Patients with solitary non-invasive neoplasms in the proximal pancreas from January 1998 to April 2014 at the Second Affiliated Hospital of Zhejiang University, Hangzhou, China were included. Different operations and outcomes were analyzed. RESULTS: A total of 123 patients were enrolled. Forty patients (32...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28988410/a-case-of-macrocystic-type-serous-cystic-neoplasm-with-repeated-pancreatitis-within-a-short-period-of-time
#14
Akihiko Kida, Yukihiro Shirota, Tsuyoshi Suda, Yuji Houdo, Katsuaki Sato, Tokio Wakabayashi
The patient was a 39-year-old woman in whom computed tomography (CT) in 201X had revealed a pancreatic cystic neoplasm (PCN) of 4.3 cm in diameter in the pancreatic body. In June 201X + 3, the patient consulted our hospital regarding severe acute pancreatitis. The condition improved through treatment with large-volume fluid replacement and continuous regional arterial infusion therapy. Thereafter, acute pancreatitis recurred twice, in November 201X + 3 and in January 201X + 4. During an 8-month period, acute pancreatitis occurred three times...
October 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28986726/acute-pancreatitis-onset-carcinoma-in-situ-of-the-pancreas-with-focal-fat-replacement-diagnosed-using-serial-pancreatic-juice-aspiration-cytologic-examination-space
#15
Tatsunori Satoh, Masataka Kikuyama, Shinya Kawaguchi, Hideyuki Kanemoto, Hiroyuki Muro, Keiji Hanada
A 59-year-old woman was admitted for acute pancreatitis. Abdominal computed tomography and magnetic resonance imaging revealed a swollen pancreatic parenchyma with dilatation of the main pancreatic duct (MPD) of the pancreas tail, which was separated from the normal pancreas body side by a locally atrophic part of the pancreas. Magnetic resonance cholangiopancreatography showed MPD stricture in the pancreas tail with dilatation of the upstream MPD. Endoscopic ultrasonography revealed that the MPD stricture of the pancreas tail was surrounded by a blurred and hypoechoic area...
October 6, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28981264/stabilizing-cupd-nanoparticles-via-cupd-coupling-to-wo2-72-nanorods-in-electrochemical-oxidation-of-formic-acid
#16
Zheng Xi, Junrui Li, Dong Su, Michelle Muzzio, Chao Yu, Qing Li, Shouheng Sun
Stabilizing a 3d-transition metal component M from an MPd alloy structure in an acidic environment is key to the enhancement of MPd catalysis for various reactions. Here we demonstrate a strategy to stabilize Cu in 5 nm CuPd nanoparticles (NPs) by coupling the CuPd NPs with perovskite-type WO2.72 nanorods (NRs). The CuPd NPs are prepared by controlled diffusion of Cu into Pd NPs, and the coupled CuPd/WO2.72 are synthesized by growing WO2.72 NRs in the presence of CuPd NPs. The CuPd/WO2.72 can stabilize Cu in 0...
October 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28973076/effect-of-dietary-supplementation-with-lutein-zeaxanthin-and-%C3%AF-3-on-macular-pigment-a-randomized-clinical-trial
#17
Jean-François Korobelnik, Marie-Bénédicte Rougier, Marie-Noëlle Delyfer, Alain Bron, Bénédicte M J Merle, Hélène Savel, Geneviève Chêne, Cécile Delcourt, Catherine Creuzot-Garcher
Importance: Nutritional uptake of lutein, zeaxanthin, and ω-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) and thereby protect against the development of age-related macular degeneration (AMD). Objectives: To estimate the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins to increase the density of macular pigment in first-generation offspring of parents with neovascular AMD...
November 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28946527/sex-differences-in-passive-lateral-and-medial-patellar-mobility-in-healthy-young-adults
#18
Susumu Ota, Hiroshi Ohko
BACKGROUND: Sex differences in passive patellar mobility have not been quantitatively evaluated. OBJECTIVE: The present study aimed to: 1) investigate sex differences in absolute and normalized patellar mobility, and 2) verify the relationship between patellar mobility and knee joint laxity. METHODS: Two hundred and five pain-free individuals (205 knees, 103 men, 102 women) participated. Passive lateral and medial patellar displacement was measured using a modified patellofemoral arthrometer and manual pushing method at 0∘ and 30∘ knee flexion angles...
September 8, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28937828/the-effects-of-systemic-alfuzosin-and-tamsulosin-hydrochloride-on-choroidal-thickness-and-pupil-diameter-sizes-in-cases-with-benign-prostatic-hyperplasia
#19
Mustafa Dogan, Bunyamin Kutluksaman, Ibrahim Keles, Mustafa Karalar, Ahmet Omer Halat
PURPOSE: To compare the effects of alfuzosin hydrochloride and tamsulosin hydrochloride on choroidal thickness (CT) and pupil diameter (PD) sizes in patients with benign prostatic hyperplasia. SUBJECTS AND METHODS: Sixty-three men patients with newly diagnosis of benign prostatic hyperplasia were randomly assigned to either alfuzosin hydrochloride or to tamsulosin hydrochloride groups in this prospective, randomized, parallel-group clinical trial. Enhanced depth imaging spectral-domain optical coherence tomography, pupillography were obtained at baseline, 1st and 3rd month, and choroidal thicknesses and pupil diameter sizes were compared between the two groups...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28934874/radiographic-shape-of-foot-with-second-metatarsophalangeal-joint-dislocation-associated-with-hallux-valgus
#20
Tetsuro Kokubo, Takeshi Hashimoto, Yasunori Suda, Akeo Waseda, Hiroko Ikezawa
BACKGROUND: Second metatarsophalangeal (MTP) joint dislocation is associated with hallux valgus, and the treatment of complete dislocation can be difficult. The purpose of this study was to radiographically clarify the characteristic foot shape in the presence of second MTP joint dislocation. METHODS: Weight-bearing foot radiographs of the 268 patients (358 feet) with hallux valgus were examined. They were divided into 2 groups: those with second MTP joint dislocation (study group = 179 feet) and those without dislocation (control group = 179 feet)...
September 1, 2017: Foot & Ankle International
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