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https://www.readbyqxmd.com/read/28538461/dnp-preparation-in-supporting-critical-skills-for-magnet%C3%A2-program-directors
#1
Sarah Lackey
Magnet® organizations are required to identify a Magnet program director (MPD), who plays a critical role in attaining and maintaining Magnet designation. The evidence is sparse related to qualifications or recommended educational levels of those assuming an MPD role. In this article, the author discusses how one of the DNP Essentials, clinical scholarship and the use of analytical methods for evidence-based practice, is reported to prepare nurses for the MPD role.
June 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28531356/spin-polarization-transfer-from-a-photogenerated-radical-ion-pair-to-a-stable-radical-controlled-by-charge-recombination
#2
Noah E Horwitz, Brian T Phelan, Jordan N Nelson, Catherine M Mauck, Matthew D Krzyaniak, Michael R Wasielewski
Photoexcitation of electron donor-acceptor molecules frequently produces radical ion pairs with well-defined initial spin-polarized states that have attracted significant interest for spintronics. Transfer of this initial spin polarization to a stable radical is predicted to depend on the rates of the radical ion pair recombination reactions, but this prediction has not been tested experimentally. In this study, a stable radical/electron donor/chromophore/electron acceptor molecule, BDPA(•)-mPD-ANI-NDI, where BDPA(•) is α,γ-bisdiphenylene-β-phenylallyl, mPD is m-phenylenediamine, ANI is 4-aminonaphthalene-1,8-dicarboximide, and NDI is naphthalene-1,4:5,8-bis(dicarboximide), was synthesized...
May 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28526350/designing-novel-bioconjugates-of-hydroxyethylcellulose-and-salicylates-for-potential-pharmaceutical-and-pharmacological-applications
#3
Khawar Abbas, Muhammad Amin, Muhammad Ajaz Hussain, Muhammad Sher, Syed Nasir Abbas Bukhari, Ibrahim Jantan, Kevin J Edgar
The present study deals with fabrication of macromolecular prodrugs (MPDs) of salicylic acid (SA) and aspirin (ASP) based on a hydrophilic cellulose ether, hydroxyethylcellulose (HEC). Degrees of substitution (DS) of SA and ASP per HEC repeating unit (HEC-RU) were achieved ranging from 0.60-2.18 and 0.53-1.50, respectively. The amphiphilic HEC-SA conjugate 2 assembled into nanowire-like structures, while HEC-ASP conjugate 6 formed nanoparticles (diameter 300-700nm) at a water/DMSO interface. After oral administration in rabbit models, conjugates 2 and 6 showed plasma half-life of 6...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28509543/exploring-the-gas-phase-activation-and-reactivity-of-a-ruthenium-transfer-hydrogenation-catalyst-by-experiment-and-theory-in-concert
#4
Fabian S Menges, Johannes Lang, Yevgeniy Nosenko, Christian Kerner, Maximilian Gaffga, Leila Taghizadeh Ghoochany, Werner Richard Thiel, Christoph Riehn, Gereon Niedner-Schatteburg
This study elucidates structures, activation barriers and the gas phase reactivity of cationic ruthenium transfer hydrogenation catalysts of the structural type [(η6-cym)RuX(pympyr)]+. In these complexes, the central ruthenium(+II) ion is coordinated to a η6-bound p-cymene (η6-cym), a bidentate 2-R-4-(2-pyridinyl)pyrimidine ligand (pympyr) with R = NH2 or N(CH3)2, and an anion X = I-, Br-, Cl-, or CF3SO3-. We present Infrared Multiple-Photon Dissociation (IR-MPD) spectra of precursors (before HCl loss) and of activated complexes (after HCl loss) which elucidates a C-H activation as the key step in the activation mechanism...
May 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28506431/usefulness-of-three-dimensional-magnetic-resonance-cholangiopancreatography-with-partial-maximum-intensity-projection-for-diagnosing-autoimmune-pancreatitis
#5
Shin Yanagisawa, Yasunari Fujinaga, Takayuki Watanabe, Masahiro Maruyama, Takashi Muraki, Masaaki Takahashi, Akira Fujita, Sachie Fujita, Masahiro Kurozumi, Kazuhiko Ueda, Hideaki Hamano, Shigeyuki Kawa, Masumi Kadoya
PURPOSE: To compare three-dimensional magnetic resonance cholangiopancreatography (MRCP) with/without partial maximum intensity projection (MIP) and endoscopic retrograde cholangiopancreatography (ERCP) in patients with autoimmune pancreatitis (AIP). MATERIALS AND METHODS: Three-dimensional MRCP and ERCP images were retrospectively analyzed in 24 patients with AIP. We evaluated the narrowing length of the main pancreatic duct (NR-MPD), multiple skipped MPD narrowing (SK-MPD), and side branches arising from the narrowed portion of the MPD (SB-MPD) using four MRCP datasets: 5 original images (MIP5), 10 original images (MIP10), all original images (full-MIP), and a combination of these three datasets (a-MIP)...
May 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28448384/cytoreductive-surgery-for-metastatic-gastrointestinal-stromal-tumors-treated-with-tyrosine-kinase-inhibitors-a-2-institutional-analysis
#6
Mark Fairweather, Vinod P Balachandran, George Z Li, Monica M Bertagnolli, Cristina Antonescu, William Tap, Samuel Singer, Ronald P DeMatteo, Chandrajit P Raut
OBJECTIVE: To refine treatment recommendations for patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs) and surgery. BACKGROUND: Early reports suggested that patients with metastatic GIST responding to TKIs treated with surgery may have favorable outcomes. However, identification of prognostic factors was limited by small cohorts. METHODS: Progression-free survival (PFS) and overall survival (OS) from time of surgery and from start of initial TKI was determined...
April 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28444792/a-computational-approach-to-study-functional-monomer-protein-molecular-interactions-to-optimize-protein-molecular-imprinting
#7
R Boroznjak, J Reut, A Tretjakov, A Lomaka, A Öpik, V Syritski
Molecular imprinting has become a promising approach for synthesis of polymeric materials having binding sites with a predetermined selectivity for a given analyte, the so-called molecularly imprinted polymers (MIPs), which can be used as artificial receptors in various application fields. Realization of binding sites in a MIP involves the formation of prepolymerization complexes between a template molecule and monomers, their subsequent polymerization, and the removal of the template. It is believed that the strength of the monomer-template interactions in the prepolymerization mixture influences directly on the quality of the binding sites in a MIP and consequently on its performance...
April 26, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28423552/enhanced-antitumor-effects-by-combining-an-il-12-anti-dna-fusion-protein-with-avelumab-an-anti-pd-l1-antibody
#8
Jonathan K Fallon, Amanda J Vandeveer, Jeffrey Schlom, John W Greiner
The combined therapeutic potential of an immunocytokine designed to deliver IL-12 to the necrotic regions of solid tumors with an anti-PD-L1 antibody that disrupts the immunosuppressive PD-1/PD-L1 axis yielded a combinatorial benefit in multiple murine tumor models. The murine version of the immunocytokine, NHS-muIL12, consists of an antibody (NHS76) recognizing DNA/DNA-histone complexes, fused with two molecules of murine IL-12 (NHS-muIL12). By its recognition of exposed DNA, NHS-muIL12 targets IL-12 to the necrotic portions of tumors; it has a longer plasma half-life and better antitumor efficacy against murine tumors than recombinant murine IL-12...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409412/microcephalic-osteodysplastic-primordial-dwarfism-type-ii-a-clinical-review
#9
REVIEW
Michael B Bober, Andrew P Jackson
PURPOSE OF THE REVIEW: This review will provide an overview of the microcephalic primordial dwarfism (MPD) class of disorders and provide the reader comprehensive clinical review with suggested care guidelines for patients with microcephalic osteodysplastic primordial dwarfism, type II (MOPDII). RECENT FINDINGS: Over the last 15 years, significant strides have been made in the diagnosis, natural history, and management of MOPDII. MOPDII is the most common and well described form of MPD...
April 13, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28400061/nonlinear-model-predictive-control-of-managed-pressure-drilling
#10
Anirudh Nandan, Syed Imtiaz
A new design of nonlinear model predictive controller (NMPC) is proposed for managed pressure drilling (MPD) system. The NMPC is based on output feedback control architecture and employs offset-free formulation proposed in [1]. NMPC uses active set method for computing control inputs. The controller implements an automatic switching from constant bottom hole pressure (CBHP) regulation to flow control mode in the event of a reservoir kick. In the flow control mode the controller automatically raises the bottom hole pressure setpoint, and thereby keeps the reservoir fluid flow to the surface within a tunable threshold...
April 8, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28395417/-dosimetry-verification-of-radioactive-seed-implantation-with-3d-printing-template-and-ct-guidance-for-paravertebral-retroperitoneal-malignant-tumor
#11
Z Ji, Y L Jiang, F X Guo, R Peng, H T Sun, J H Fan, J J Wang
Objective: To compare the dose distributions of postoperative plans with preoperative plans for seeds implantations of paravertebral/retroperitoneal tumors assisted by 3D printing guide template and CT guidance, explore the effects of the technology for seeds implantations in dosimetry level and provide data support for the optimization and standardization in seeds implantation. Methods: Between December 2015 and July 2016, a total of 10 patients with paravertebral/retroperitoneal tumors (12 lesions) received 3D printing template assist radioactive seeds implantations in department of radiation oncology of Peking University Third Hospital, and included in the study...
April 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28381785/resection-of-carcinoma-in-situ-and-minimally-invasive-carcinoma-of-the-pancreas-in-a-patient-presenting-with-stenosis-and-post-stenotic-dilatation-of-the-main-pancreatic-duct-on-endoscopic-ultrasonography-and-positive-serial-pancreatic-juice-aspiration-cytology
#12
Koushiro Ohtsubo, Hisatsugu Mouri, Kaname Yamashita, Isamu Makino, Hidehiro Tajima, Tetsuo Ohta, Dai Inoue, Toshifumi Gabata, Hiroko Ikeda, Yoh Zen, Hiroyuki Watanabe
We report a rare case of a 67-year-old man who underwent resection of carcinoma in situ and minimally invasive carcinoma of the pancreas. The patient presented with upper abdominal and back pain. No definite pancreatic mass was detected on abdominal ultrasonography, computed tomography, magnetic resonance imaging (MRI), or endoscopic ultrasonography (EUS). However, EUS and MRI demonstrated stenosis of the main pancreatic duct (MPD) in the body and post-stenotic dilatation, resulting in mild dilatation of MPD in the tail...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28374712/-external-pancreatic-fistulas-management
#13
E V Stepan, A S Ermolov, M L Rogal', Yu S Teterin
The main principles of treatment of external postoperative pancreatic fistulas are viewed in the article. Pancreatic trauma was the reason of pancreatic fistula in 38.7% of the cases, operations because of acute pancreatitis - in 25.8%, and pancreatic pseudocyst drainage - in 35.5%. 93 patients recovered after the treatment. Complex conservative treatment of EPF allowed to close fistulas in 74.2% of the patients with normal patency of the main pancreatic duct (MPD). The usage of octreotide 600-900 mcg daily for at least 5 days to decrease pancreatic secretion was an important part of the conservative treatment...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28301149/methyl-protodioscin-induces-apoptosis-in-human-osteosarcoma-cells-by-caspase-dependent-and-mapk-signaling-pathways
#14
Shun-Cheng Tseng, Tai-Shan Shen, Chia-Chieh Wu, Ing-Lin Chang, Hsin-Yao Chen, Chen-Pu Hsieh, Chun-Hsiang Cheng, Chiu-Liang Chen
Methyl protodioscin (MPD), a furostanol saponin derived from the rhizomes of Dioscorea collettii var. hypoglauca (Dioscoreaceae), has been shown to exhibit broad bioactivities such as anti-inflammation and antitumor activities. Here, we explored the molecular mechanisms by which MPD induced apoptosis in MG-63 cells. The data showed that MPD significantly suppressed cell growth (cell viabilities: 22.5 ± 1.9% for 8 μM MPD versus 100 ± 1.4% for control, P < 0.01) and enhanced cell apoptosis. The exposure to MPD resulted in a significant induction of reactive oxygen species, loss of mitochondrial membrane potential, and activation of caspase-9 and caspase-3 (P < 0...
March 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28281124/major-pancreatic-duct-continuity-is-the-crucial-determinant-in-the-management-of-blunt-pancreatic-injury-a-pancreatographic-classification
#15
Being-Chuan Lin, Yon-Cheong Wong, Ray-Jade Chen, Nai-Jen Liu, Cheng-Hsien Wu, Tsann-Long Hwang, Yu-Pao Hsu
BACKGROUND: To evaluate the management and outcomes of blunt pancreatic injuries based on the integrity of the major pancreatic duct (MPD). METHODS: Between August 1996 and August 2015, 35 patients with blunt pancreatic injuries underwent endoscopic retrograde pancreatography (ERP). Medical charts were retrospectively reviewed for demography, ERP timing, imaging findings, management, and outcome. RESULTS: Of the 35 patients, 21 were men and 14 were women, with ages ranging from 11 to 70 years...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28270509/in-situ-and-in-silico-kinetic-analyses-of-programmed-cell-death-1-pd-1-receptor-programmed-cell-death-ligands-and-b7-1-protein-interaction-network
#16
Kaitao Li, Xiaoxiao Cheng, Andreas Tilevik, Simon J Davis, Cheng Zhu
Programmed cell death-1 (PD-1) is an inhibitory receptor with an essential role in maintaining peripheral tolerance and is among the most promising immunotherapeutic targets for treating cancer, autoimmunity, and infectious diseases. A complete understanding of the consequences of PD-1 engagement by its ligands, PD-L1 and PD-L2, and of PD-L1 binding to B7-1 requires quantitative analysis of their interactions at the cell surface. We present here the first complete in situ kinetic analysis of the PD-1/PD-ligands/B7-1 system...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28258561/a-resected-case-of-two-branch-duct-type-intraductal-papillary-mucinous-neoplasms-showing-different-clinical-courses-after-a-two-year-follow-up
#17
Hideki Shibata, Nobuyuki Ohike, Tomoko Norose, Tomohide Isobe, Reika Suzuki, Hideyuki Imai, Akira Shiokawa, Masafumi Takimoto, Akihiro Tabuchi, Yuichi Takano, Eiichi Yamamura, Masatsugu Nagahama, Nobuyuki Takeyama, Kazuaki Yokomizo, Hiroki Mizukami, Jun-Ichi Tanaka, Takeshi Aoki, Masahiko Murakami
The patient was a 60-year-old man without any particular complaints, but he underwent abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) due to a fatty liver, which revealed two similar cystic lesions regarded as branch duct-type intraductal papillary mucinous neoplasm (BD-IPMN) in the pancreatic body [BD-IPMN (b), 16 mm in size] and tail [BD-IPMN (t), 13 mm in size] without a "high-risk stigmata" or "worrisome features". He subsequently received follow-up by MRCP every 6 months...
June 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28241620/tunable-microwave-photonic-duplexer-for-full-duplex-radio-over-fiber-access
#18
Peixuan Li, Wei Pan, Xihua Zou, Lianshan Yan, Bin Luo, Bing Lu
A tunable microwave photonic duplexer (MPD) for full-duplex radio-over-fiber access is proposed and experimentally demonstrated. The proposed MPD is implemented by two single-bandpass microwave photonic filters (MPFs) to separate the transmit (Tx) and receive (Rx) channels. More specifically, a broadband optical source (BOS) is spectrally sliced by a differential-group-delay interferometer (DGDI) and a Mach-Zehnder interferometer (MZI) to form two tunable single-bandpass MPFs with different central frequencies...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28236277/dual-drainage-using-a-percutaneous-pancreatic-duct-technique-contributed-to-resolution-of-severe-acute-pancreatitis
#19
Tatsunori Satoh, Masataka Kikuyama, Yoshihiro Yokoi, Shinya Kawaguchi
A 66-year-old man was admitted for severe acute alcoholic pancreatitis with infected pancreatic necrosis (IPN). Abdominal computed tomography revealed an inflamed pancreatic head, a dilated main pancreatic duct (MPD), and a large cavity with heterogeneous fluid containing gas adjacent to the pancreatic head, and extending to the pelvis. The cavity was drained percutaneously near the pancreatic head on admission; another tube was inserted into the pelvic cavity on hospital day 3. The drained fluid contained pus with high amylase concentration...
April 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28208297/label-free-lspr-detection-of-trace-lead-ii-ions-in-drinking-water-by-synthetic-poly-mpd-co-asa-nanoparticles-on-gold-nanoislands
#20
Guangyu Qiu, Siu Pang Ng, Xiongyi Liang, Ning Ding, Xiangfeng Chen, Chi-Man Lawrence Wu
Using self-assembly gold nanoislands (SAM-AuNIs) functionalized by poly(m-phenylenediamine-co-aniline-2-sulfonic acid) (poly(mPD-co-ASA)) copolymer nanoparticles as specific receptors, a highly sensitive localized surface plasmon resonance (LSPR) optochemical sensor is demonstrated for detection of trace lead cation (Pb(II)) in drinking water. The copolymer receptor is optimized in three aspects: (1) mole ratio of mPD:ASA monomers, (2) size of copolymer nanoparticles, and (3) surface density of the copolymer...
February 7, 2017: Analytical Chemistry
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