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https://www.readbyqxmd.com/read/29291020/about-mirnas-mirna-seeds-target-genes-and-target-pathways
#1
Tim Kehl, Christina Backes, Fabian Kern, Tobias Fehlmann, Nicole Ludwig, Eckart Meese, Hans-Peter Lenhof, Andreas Keller
miRNAs are typically repressing gene expression by binding to the 3' UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of thoughts is: miRNAs with similar (seed) sequence target similar sets of genes and thus similar sets of pathways. By calculating similarity scores for all 3.25 million pairs of 2,550 human miRNAs, we found that this pattern frequently holds, while we also observed exceptions...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290022/omega-3-fatty-acids-supplementation-with-lithium-and-aripiprazole-for-improving-the-balance-of-circulating-hormones-and-brain-neurotransmitters-in-manic-mice-model
#2
Pandiyan Arunagiri, Elumalai Balamurugan, Murugesan Saravanakumar, Mackraj Irene
The present study was designed to evaluate the combined effect of lithium and aripiprazole supplemented with omega-3 fatty acids in methylphenidate (MPD)-induced manic mice. Swiss albino mice were administered with MPD or saline for 14 days, and based on changes in behavioral activities animals were treated with lithium, aripiprazole, and omega-3 fatty acids from the 8th day. Behavioral patterns were analyzed by video tracking. Thyroxine, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were assayed in serum using ELISA kits...
December 30, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29238101/feasibility-of-the-unilateral-flange-stent-for-the-treatment-of-benign-pancreatic-duct-stricture-a-pilot-study
#3
Patommatat Bhanthumkomol, Kazuo Hara, Nobumasa Mizuno, Susumu Hijioka, Nozomi Okuno, Tsukasa Yoshida, Junya Tokuhisa, Sith Siramolpiwat, Ratha-Korn Vilaichone, Bubpha Pornthisarn, Yasumasa Niwa, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Kenji Yamao
Endoscopic placement of the plastic stent has been adopted as an initial treatment for chronic pancreatitis with pancreatic duct stricture. Stent fracture while attempting removal is one of the complications of stent exchange. The use of the unilateral-flange stent in these patients has never been reported. We investigated the outcomes associated with the use of this stent with regard to stent exchange and stent-related adverse events. From 2011 to 2015, 9 patients with chronic pancreatitis and main pancreatic duct (MPD) stricture treated with the unilateral-flange stent were included...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29217902/magnitude-severity-and-outcome-of-traumatic-pancreatic-injury-at-a-level-i-trauma-center-in-india
#4
Amit Gupta, Subodh Kumar, Sanjay Kumar Yadav, Biplab Mishra, Maneesh Singhal, Atin Kumar, Pramod Garg
Pancreatic injury is an uncommon and frequently missed injury in abdominal trauma patients. However, missed pancreatic injury is associated with significant morbidity and mortality. This study was conducted to know the burden of pancreatic injury and its outcome in our setup. A retrospective analysis of 53 patients with pancreatic injury from January 2008 through March 2012 at the Jai Prakash Narayan Apex Trauma Center (JPNATC), All India Institute of Medical Sciences (AIIMS), New Delhi. Pancreatic injuries were present in 1...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29212451/a-small-pancreatic-hamartoma-with-an-obstruction-of-the-main-pancreatic-duct-and-avid-fdg-uptake-mimicking-a-malignant-pancreatic-tumor-a-systematic-case-review
#5
Hiroaki Nagano, Masayuki Nakajo, Yoshihiko Fukukura, Yoriko Kajiya, Atsushi Tani, Sadao Tanaka, Mari Toyota, Toru Niihara, Masaki Kitazono, Toyokuni Suenaga, Takashi Yoshiura
BACKGROUND: Pancreatic hamartomas are extremely rare and may be misdiagnosed as malignant tumors. We report herein a case of a small, solid-type pancreatic hamartoma. CASE PRESENTATION: A 72-year-old female was incidentally detected pancreatic lesion by ultrasonography. Computed tomography and magnetic resonance imaging revealed a 2.0-cm solid lesion. The main pancreatic duct (MPD) was obstructed by the lesion in the head of the pancreas, and the upstream MPD was dilated...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29191006/selective-and-mechanically-robust-sensors-for-electrochemical-measurements-of-real-time-hydrogen-peroxide-dynamics-in-vivo
#6
Leslie R Wilson, Sambit Panda, Andreas C Schmidt, Leslie A Sombers
The role of hydrogen peroxide (H2O2) in the complex environment of the brain is not well understood. H2O2 plays several important roles - for instance, it serves as a key chemical player in normal physiological processes such as cellular respiration, a modulator of dopaminergic signaling, and its presence can indicate the upstream production of more aggressive and short-lived reactive oxygen species (ROS). As such, H2O2 has been implicated in several neurodegenerative diseases, including the slow destruction of dopaminergic neurons in Parkinson's disease (PD)...
December 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29185614/permanent-pacing-after-transcatheter-aortic-valve-implantation-incidence-predictors-and-evolution-of-left-ventricular-function
#7
Cláudio Monteiro, Andres Di Leoni Ferrari, Paulo Ricardo Avancini Caramori, Luiz Antonio Ferreira Carvalho, Dimytri Alexandre de Alvim Siqueira, Luiz Eduardo Koenig São Thiago, Marco Perin, Valter C de Lima, Enio Guérios, Fabio Sandoli De Brito
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a well-established procedure; however, atrioventricular block requiring permanent pacemaker implantation (PPI) is a common complication. OBJECTIVES: To determine the incidence, predictors and clinical outcomes of PPI after TAVI, focusing on how PPI affects left ventricular ejection fraction (LVEF) after TAVI. METHODS: The Brazilian Multicenter TAVI Registry included 819 patients submitted to TAVI due to severe aortic stenosis from 22 centers from January/2008 to January/2015...
November 27, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29163970/effect-of-low-dose-aspirin-use-on-pancreatic-cancer-development-and-morphological-changes-on-imaging-in-ipmn-a-long-term-cohort-study
#8
Yusuke Takasaki, Naoyoshi Nagata, Koh Imbe, Yuya Hisada, Katsunori Sekine, Tsuyoshi Tajima, Mikio Yanase, Kazuma Fujimoto, Junichi Akiyama, Naomi Uemura
Background: Aspirin use may reduce the incidence of pancreatic cancer (PC), but no data are available regarding its chemopreventive effects on intraductal papillary mucinous neoplasm (IPMN). We aimed to determine whether low-dose aspirin (LDA) reduces PC development and morphological changes on imaging in IPMN patients. Methods: A cohort of 448 IPMN patients periodically followed up with imaging tests was analyzed. We used one-to-two propensity score matching to adjust for differences between an LDA group (n = 63) and a non-LDA group (n = 385)...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29145338/pancreatogenic-choledocholithiasis-in-common-bile-duct-stump-after-roux-en-y-hepaticojejunostomy-a-case-report
#9
Yuan-Hui Jiang, An-Hong Zhang, Shao-Jun Zhou
RATIONALE: Choledocholithiasis in common bile duct (CBD) stump after Roux-en-Y hepaticojejunostomy (RYHJ) is incredibly rare and its pathophysiology is poorly understood. PATIENT CONCERNS: A 79-year-old woman was admitted to our hospital with upper abdominal pain radiating through to the back in November 2016. DIAGNOSES: Abdominal computed tomography (CT) scan and magnetic resonance cholangiopancreatography (MRCP) revealed filling defects in CBD stump, chronic pancreatitis, and dilatation of CBD stump and main pancreatic duct (MPD)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143464/mean-platelet-diameter-measurements-to-classify-inherited-thrombocytopenias
#10
K Fixter, D J Rabbolini, B Valecha, M-C Morel-Kopp, S Gabrielli, Q Chen, W S Stevenson, C M Ward
INTRODUCTION: Mean platelet volume (MPV) assists the differential diagnosis of inherited thrombocytopenia (IT) but lacks standardisation and varies between automated analysers. Classification of IT based on mean platelet diameter (MPD) has been proposed by an international collaborative study but has not been validated. METHODS: To assess the applicability of MPD to classify forms of IT, digital images of blood films from patients with established genetic causes for IT were generated, and the MPD measured (ZEISS Axio-scanner and Image J software) by a blinded reviewer...
November 16, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29136208/mouse-phenome-database-an-integrative-database-and-analysis-suite-for-curated-empirical-phenotype-data-from-laboratory-mice
#11
Molly A Bogue, Stephen C Grubb, David O Walton, Vivek M Philip, Georgi Kolishovski, Tim Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29111650/surface-engineering-of-thin-film-composite-polyamide-membranes-with-silver-nanoparticles-through-layer-by-layer-interfacial-polymerization-for-antibacterial-properties
#12
Zhongyun Liu, Longbin Qi, Xiaochan An, Caifeng Liu, Yunxia Hu
We developed a simple and facile approach to covalently immobilize Ag nanoparticles (NPs) onto polyamide surfaces of thin film composite membranes through layer-by-layer interfacial polymerization (LBL-IP) for biofouling mitigation. Stable and uniform bovine serum albumin (BSA) capped Ag NPs with an average diameter of around 20 nm were synthesized using BSA as a template under the assistance of sonication, and Ag NPs incorporated thin film composite (TFC) polyamide membrane was then fabricated by LBL-IP on a nanoporous polysulfone (PSf) substrate upon sequential coating with m-phenylenediamine (MPD) aqueous solution, trimesoyl chloride (TMC)-hexane solution, and finally BSA-capped Ag NPs aqueous solution...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29097239/studies-on-the-environmental-fate-ecotoxicology-and-toxicology-of-2-methyl-1-3-propanediol
#13
REVIEW
J Fowles, C Lewis, E Rushton
2-methyl 1,3-propandiol (MPD) is a low molecular weight, colorless glycol used in polymer and coating applications. The log Kow of -0.6 suggests partitioning to aqueous phases with a low concern for possible bioaccumulation. MPD was found to be inherently biodegradable. Ecotoxicological results in several aquatic and terrestrial species found no significant hazard potential. MPD is rapidly absorbed via the oral and dermal routes, metabolized to 3-hydroxybutyrate, and excreted in urine with a half-life of 3...
October 28, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29094932/preparation-of-an-efficient-ratiometric-fluorescent-nanoprobe-m-cds-ru-bpy-3-2-for-visual-and-specific-detection-of-hypochlorite-on-site-and-in-living-cells
#14
Yuanjin Zhan, Fang Luo, Longhua Guo, Bin Qiu, Yuhong Lin, Juan Li, Guonan Chen, Zhenyu Lin
Hypochlorite (ClO(-)) is one of the most important reactive oxygen species (ROS), which plays an important role in sustaining human innate immunity during microbial invasion. Moreover, ClO(-) is a powerful oxidizer for water treatment. The safety of drinking water is closely related to its content. Herein, m-phenylenediamine (mPD) is used as a precursor to prepare carbon dots (named m-CDs) with highly fluorescent quantum yield (31.58% in water), and our investigation shows that the strong fluorescent emission of m-CDs can be effectively quenched by ClO(-)...
November 9, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29090586/diagnosis-and-treatment-of-myh9-rd-in-an-australasian-cohort-with-thrombocytopenia
#15
David J Rabbolini, Yenna Chun, Maya Latimer, Shinji Kunishima, Kathleen Fixter, Bhavia Valecha, Peter Tan, Lee Ping Chew, Benjamin T Kile, Rachel Burt, Kottayam Radhakrishnan, Robert Bird, Paul Ockelford, Sara Gabrielli, Qiang Chen, William S Stevenson, Christopher M Ward, Marie-Christine Morel-Kopp
MYH9-related disorders (MYH9-RDs) caused by mutation of the MYH9 gene which encodes non-muscle myosin heavy-chain-IIA (NMMHC-IIA), an important motor protein in hemopoietic cells, are the most commonly encountered cause of inherited macrothrombocytopenia. Despite distinguishing features including an autosomal dominant mode of inheritance, giant platelets on the peripheral blood film accompanied by leucocytes with cytoplasmic inclusion bodies (döhle-like bodies), these disorders remain generally under-recognized and often misdiagnosed as immune thrombocytopenia (ITP)...
November 1, 2017: Platelets
https://www.readbyqxmd.com/read/29082243/mammary-and-extramammary-paget-s-disease-presented-different-expression-pattern-of-steroid-hormone-receptors
#16
Songxia Zhou, Weixiang Zhong, Ruiqin Mai, Guohong Zhang
BACKGROUND AND OBJECTIVES: Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD. METHODS: Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. RESULTS: Positive expression of AR was significantly higher in EMPD (61...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29023679/explaining-ecosystem-multifunction-with-evolutionary-models
#17
Marc W Cadotte, Stuart W Livingstone, Simone-Louise E Yasui, Russell Dinnage, Jin-Tian Li, Robin Marushia, James Santangelo, Wensheng Shu
Ecosystem function is the outcome of species interactions, traits, and niche overlap -all of which are influenced by evolution. However, it is not well understood how the tempo and mode of niche evolution can influence ecosystem function. In evolutionary models where either species differences accumulate through random drift in a single trait or species differences accumulate through divergent selection among close relatives, we should expect that ecosystem function is strongly related to diversity. However, when strong selection causes species to converge on specific niches or when novel traits that directly affect function evolve in some clades but not others, the relationship between diversity and ecosystem function might not be very strong...
October 11, 2017: Ecology
https://www.readbyqxmd.com/read/29023105/specific-detection-of-carcinoembryonic-antigen-based-on-fluorescence-quenching-of-hollow-porous-gold-nanoshells-with-roughened-surface
#18
Ting-Yang Xing, Jing Zhao, Guo-Jun Weng, Jian Zhu, Jian-Jun Li, Jun-Wu Zhao
The detection of tumor biomarkers in the early stage is highly desirable for the therapy of cancer. However, rapid, low-cost, sensitive, and selective detection of biomarkers remains a challenge owing to the sequence homology, short length, and low abundance. This Research Article describes the synthesis of a novel carcinoembryonic antigen (CEA) probe using hollow porous gold nanoparticles (HPGNPs) with roughened surface based on fluorescence quenching. For specific detection of CEA, the surface of HPGNP is modified by carboxyl modification, carboxyl activation, and antibody conjugation...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28991803/enhanced-flux-performance-of-polyamide-composite-membranes-prepared-via-interfacial-polymerization-assisted-with-ethyl-formate
#19
Zhaofeng Liu, Guiru Zhu, Yulin Wei, Dapeng Zhang, Lei Jiang, Haizeng Wang, Congjie Gao
A novel thin film composite (TFC) polyamide reverse osmosis membrane was prepared via the interfacial polymerization of m-phenylene diamine (MPD) in aqueous phase and 1,3,5-trimesoyl chloride (TMC) in organic phase on a polysulfone ultrafiltration support by assisting with ethyl formate as a co-solvent added in the organic phase. The ethyl formate added in the organic phase is intended to form a narrow miscibility zone, which leads to the thicker reaction zone. The multi-layered loose polyamide structure with larger pore size was formed due to the thicker reaction zone and lower content of MPD...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28990381/enucleation-of-non-invasive-tumors-in-the-proximal-pancreas-indications-and-outcomes-compared-with-standard-resections
#20
Wen-Jie Lu, Hao-Lei Cai, Ma-Dong Ye, Yu-Lian Wu, Bin Xu
OBJECTIVE: The aim of this study was to evaluate the safety and efficiency of enucleation (EU) for proximal pancreatic non-invasive neoplasms. METHODS: Patients with solitary non-invasive neoplasms in the proximal pancreas from January 1998 to April 2014 at the Second Affiliated Hospital of Zhejiang University, Hangzhou, China were included. Different operations and outcomes were analyzed. RESULTS: A total of 123 patients were enrolled. Forty patients (32...
2017: Journal of Zhejiang University. Science. B
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