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https://www.readbyqxmd.com/read/28301149/methyl-protodioscin-induces-apoptosis-in-human-osteosarcoma-cells-by-caspase-dependent-and-mapk-signaling-pathways
#1
Shun-Cheng Tseng, Tai-Shan Shen, Chia-Chieh Wu, Ing-Lin Chang, Hsin-Yao Chen, Chen-Pu Hsieh, Chun-Hsiang Cheng, Chiu-Liang Chen
Methyl protodioscin (MPD), a furostanol saponin derived from the rhizomes of Dioscorea collettii var. hypoglauca (Dioscoreaceae), has been shown to exhibit broad bioactivities such as anti-inflammation and antitumor activities. Here, we explored the molecular mechanisms by which MPD induced apoptosis in MG-63 cells. The data showed that MPD significantly suppressed cell growth (cell viabilities: 22.5 ± 1.9% for 8 μM MPD versus 100 ± 1.4% for control, P < 0.01) and enhanced cell apoptosis. The exposure to MPD resulted in a significant induction of reactive oxygen species, loss of mitochondrial membrane potential, and activation of caspase-9 and caspase-3 (P < 0...
March 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28281124/major-pancreatic-duct-continuity-is-the-crucial-determinant-in-the-management-of-blunt-pancreatic-injury-a-pancreatographic-classification
#2
Being-Chuan Lin, Yon-Cheong Wong, Ray-Jade Chen, Nai-Jen Liu, Cheng-Hsien Wu, Tsann-Long Hwang, Yu-Pao Hsu
BACKGROUND: To evaluate the management and outcomes of blunt pancreatic injuries based on the integrity of the major pancreatic duct (MPD). METHODS: Between August 1996 and August 2015, 35 patients with blunt pancreatic injuries underwent endoscopic retrograde pancreatography (ERP). Medical charts were retrospectively reviewed for demography, ERP timing, imaging findings, management, and outcome. RESULTS: Of the 35 patients, 21 were men and 14 were women, with ages ranging from 11 to 70 years...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28270509/in-situ-and-in-silico-kinetic-analyses-of-the-programmed-cell-death-1-programmed-cell-death-ligands-and-b7-1-interaction-network
#3
Kaitao Li, Xiaoxiao Cheng, Andreas Tilevik, Simon J Davis, Cheng Zhu
Programmed cell death-1 (PD-1) is an inhibitory receptor with an essential role in maintaining peripheral tolerance, and among the most promising immunotherapeutic targets for treating cancer, autoimmunity, and infectious diseases. A complete understanding of the consequences of PD-1 engagement by its ligands, PD-L1 and PD-L2, and of PD-L1 binding to B7-1, requires quantitative analysis of their interactions at the cell surface. We present here the first complete in situ kinetic analysis of the PD-1/PD-1 ligands/B7-1 system...
March 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28258561/a-resected-case-of-two-branch-duct-type-intraductal-papillary-mucinous-neoplasms-showing-different-clinical-courses-after-a-two-year-follow-up
#4
Hideki Shibata, Nobuyuki Ohike, Tomoko Norose, Tomohide Isobe, Reika Suzuki, Hideyuki Imai, Akira Shiokawa, Masafumi Takimoto, Akihiro Tabuchi, Yuichi Takano, Eiichi Yamamura, Masatsugu Nagahama, Nobuyuki Takeyama, Kazuaki Yokomizo, Hiroki Mizukami, Jun-Ichi Tanaka, Takeshi Aoki, Masahiko Murakami
The patient was a 60-year-old man without any particular complaints, but he underwent abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) due to a fatty liver, which revealed two similar cystic lesions regarded as branch duct-type intraductal papillary mucinous neoplasm (BD-IPMN) in the pancreatic body [BD-IPMN (b), 16 mm in size] and tail [BD-IPMN (t), 13 mm in size] without a "high-risk stigmata" or "worrisome features". He subsequently received follow-up by MRCP every 6 months...
March 3, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28241620/tunable-microwave-photonic-duplexer-for-full-duplex-radio-over-fiber-access
#5
Peixuan Li, Wei Pan, Xihua Zou, Lianshan Yan, Bin Luo, Bing Lu
A tunable microwave photonic duplexer (MPD) for full-duplex radio-over-fiber access is proposed and experimentally demonstrated. The proposed MPD is implemented by two single-bandpass microwave photonic filters (MPFs) to separate the transmit (Tx) and receive (Rx) channels. More specifically, a broadband optical source (BOS) is spectrally sliced by a differential-group-delay interferometer (DGDI) and a Mach-Zehnder interferometer (MZI) to form two tunable single-bandpass MPFs with different central frequencies...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28236277/dual-drainage-using-a-percutaneous-pancreatic-duct-technique-contributed-to-resolution-of-severe-acute-pancreatitis
#6
Tatsunori Satoh, Masataka Kikuyama, Yoshihiro Yokoi, Shinya Kawaguchi
A 66-year-old man was admitted for severe acute alcoholic pancreatitis with infected pancreatic necrosis (IPN). Abdominal computed tomography revealed an inflamed pancreatic head, a dilated main pancreatic duct (MPD), and a large cavity with heterogeneous fluid containing gas adjacent to the pancreatic head, and extending to the pelvis. The cavity was drained percutaneously near the pancreatic head on admission; another tube was inserted into the pelvic cavity on hospital day 3. The drained fluid contained pus with high amylase concentration...
April 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28208297/label-free-lspr-detection-of-trace-lead-ii-ions-in-drinking-water-by-synthetic-poly-mpd-co-asa-nanoparticles-on-gold-nanoislands
#7
Guangyu Qiu, Siu Pang Ng, Xiongyi Liang, Ning Ding, Xiangfeng Chen, Chi-Man Lawrence Wu
Using self-assembly gold nanoislands (SAM-AuNIs) functionalized by poly(m-phenylenediamine-co-aniline-2-sulfonic acid) (poly(mPD-co-ASA)) copolymer nanoparticles as specific receptors, a highly sensitive localized surface plasmon resonance (LSPR) optochemical sensor is demonstrated for detection of trace lead cation (Pb(II)) in drinking water. The copolymer receptor is optimized in three aspects: (1) mole ratio of mPD:ASA monomers, (2) size of copolymer nanoparticles, and (3) surface density of the copolymer...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28197377/pd-l1-cd274-promoter-methylation-predicts-survival-in-colorectal-cancer-patients
#8
Diane Goltz, Heidrun Gevensleben, Jörn Dietrich, Dimo Dietrich
This study evaluates promoter methylation of the programmed cell death ligand 1 (PD-L1) as a biomarker in a cohort of 383 colorectal cancer patients. PD-L1 methylation (mPD-L1) was inversely correlated with PD-L1 mRNA expression (p = 0.001) and was associated with significantly shorter overall survival (OS, p = 0.003) and recurrence-free survival (RFS, p < 0.001). In age-stratified multivariate Cox proportional hazards analyses including sex, tumor, nodal, distant metastasis categories, microsatellite instability (MSI)-status, and PD-L1 mRNA, mPD-L1 is classified as an independent prognostic factor (OS: p = 0...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28190422/cyclists
#9
Kristiann C Heesch, Amy Schramm, Ashim Kumar Debnath, Narelle Haworth
Issues addressed: Cyclists' perceptions of harassment from motorists discourages cycling. This study examined changes in cyclists' reporting of harassment pre- to post-introduction of the Queensland trial of the minimum passing distance road rule amendment (MPD-RRA).Methods: Cross-sectional online surveys of cyclists in Queensland, Australia were conducted in 2009 (pre-trial; n=1758) and 2015 (post-trial commencement; n=1997). Cyclists were asked about their experiences of harassment from motorists while cycling...
February 9, 2017: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/28160264/impact-of-data-driven-cardiac-respiratory-motion-correction-on-the-extent-and-severity-of-myocardial-perfusion-defects-with-free-breathing-czt-spect
#10
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Hatem Boulahdour
BACKGROUND: We previously reported the clinical feasibility and positive impact on image characteristics of a data-driven cardiac respiratory motion (RM) correction method (REGAT) applicable to CZT SPECT myocardial perfusion imaging (MPI). Here, we evaluate its impact on the extent and severity of myocardial perfusion defects (MPD). METHODS: We included 25 patients having a 1-day (99m)Tc-Tetrofosmin stress/rest MPI acquired with multi-pinhole CZT SPECT. Acquisitions were processed with REGAT to generate mean RM gated SPECT...
February 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28158088/launch-light-dependency-of-step-index-multimode-fiber-connections-analyzed-by-modal-power-distribution-using-encircled-angular-flux
#11
Shigeru Kobayashi, Manabu Yasukawa, Okihiro Sugihara
The propagating modal power distribution (MPD) of step-index multimode fibers (SI-MMFs), which strongly influences the performance of systems and components composed of these fibers, has not often been discussed, because, until recently, there has been no definition to show the MPD. Encircled angular flux (EAF) is a newly developed metric for defining the MPD in step-index multimode waveguides including fibers standardized by the International Electrotechnical Commission. Using the combined analysis of EAF and insertion loss, we studied the launch light dependency of SI-MMF connections...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28144718/diagnostic-performance-and-imaging-features-for-predicting-the-malignant-potential-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-a-comparison-of-eus-contrast-enhanced-ct-and-mri
#12
Seo-Youn Choi, Jung Hoon Kim, Mi Hye Yu, Hyo Won Eun, Hae Kyung Lee, Joon Koo Han
PURPOSE: To compare diagnostic performance for prediction of malignant potential in IPMNs between EUS, contrast-enhanced CT and MRI. MATERIALS AND METHODS: 76 patients with IPMN (benign = 37, malignant = 39) underwent EUS, contrast-enhanced CT, and MRI. EUS was analyzed based on formal reports and contrast-enhanced CT and MRI were retrospectively analyzed by two radiologists according to the consensus guidelines 2012. Diagnostic performance and imaging features of malignant IPMNs were analyzed using ROC analysis and multivariate analyses...
January 31, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28140616/associations-between-food-insecurity-and-the-severity-of-psychological-distress-among-african-americans
#13
Nickolas L Allen, Benjamin J Becerra, Monideepa B Becerra
BACKGROUND: Little research exists on the association between food insecurity and mild to moderate psychological distress (MPD) among Black/African-Americans. In this study, we assess the relationship between food insecurity with and without hunger to that of both MPD and serious psychological distress (SPD) among this population. METHODS: 2009 and 2011/2012 adult public-use data from African-American respondents of the California Health Interview Survey were utilized for this study (n = 4003)...
January 31, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28133320/-a-case-of-multiple-pancreatic-metastases-from-renal-cell-carcinoma-diagnosed-using-eus-fna
#14
Chikato Koga, Masahiro Murakami, Junzo Shimizu, Akinobu Yasuyama, Tae Matsumura, Chizu Kameda, Ryohei Kawabata, Naofumi Oda, Masaki Hirota, Masato Yoshikawa, Hirotaka Morishima, Shingo Noura, Nobuki Matsunami, Junichi Hasegawa
The patient was a 79-year-old man, who underwent left nephrectomy for left renal cell carcinoma in 2007. In March 2015, he complained ofthirst, polydipsia, and polyuria. A slight elevation ofamylase levels was detected following laboratory testing. Abdominal CT revealed well-enhanced tumors in the pancreatic head and tail. MPD was dilated in the pancreatic body and tail. Endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)was used to obtain additional pathological findings. We diagnosed multiple pancreatic metastases from renal cell carcinoma using cell block sections from EUS-FNA ofthe pancreatic head tumor...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131797/a-solid-pseudopapillary-neoplasm-of-the-pancreas-in-a-man-presenting-with-acute-pancreatitis-a-case-report
#15
Emi Chikuie, Saburo Fukuda, Hirofumi Tazawa, Toshihiro Nishida, Hideto Sakimoto
INTRODUCTION: A solid pseudopapillary neoplasm (SPN) of the pancreas is rare neoplasm that occurs predominantly in young women. The clinical presentation of SPNs is nonspecific, but acute pancreatitis is rare in the reported literature. PRESENTATION OF CASE: A 36-year-old man was referred to our hospital because of upper abdominal pain and elevation of serum amylase. A computed tomography (CT) scan showed swelling of the pancreas body and a poorly enhanced and indistinct mass in the pancreas body...
January 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28129231/specific-radiological-imaging-findings-in-patients-with-hereditary-pancreatitis-during-a-long-follow-up-of-disease
#16
Aura A J van Esch, Joost P H Drenth, John J Hermans
OBJECTIVES: Hereditary pancreatitis (HP) is characterized by recurrent episodes of inflammation of the pancreas. Radiological imaging is used to diagnose HP and to monitor complications. The aim of this study was to describe specific imaging findings in HP. METHODS: We retrospectively collected data of HP patients with serial imaging and reviewed all radiological imaging studies (transabdominal ultrasonography, computed tomography, and magnetic resonance imaging)...
March 2017: Pancreas
https://www.readbyqxmd.com/read/28114893/a-case-of-multicentric-pancreatic-mixed-acinar-ductal-carcinoma-diagnosed-by-a-yogurt-like-cell-clump-flowing-from-the-papilla-of-vater
#17
Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka, Hiroyuki Ono
BACKGROUND: Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was successfully diagnosed by a biopsy of a novel object expelled from the papilla. CASE PRESENTATION: A 71-year-old male was referred because of elevated serum pancreatic enzymes. Computed tomography revealed an unclear low-density area in the pancreatic body without evidence of tumor and mild dilation of the upstream main pancreatic duct (MPD)...
January 23, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28111275/concomitant-behavioral-and-pfc-neuronal-activity-recorded-following-dose-response-protocol-of-mpd-in-adult-male-rats
#18
Sidish S Venkataraman, Catherine Claussen, Michael Joseph, Nachum Dafny
The use of methylphenidate (MPD), a commonly prescribed drug to treat attention-deficit hyperactivity disorder (ADHD), has steadily increased over the past 25 years. This trend has been accompanied by more MPD abuse by ordinary individuals for its cognitive enhancing effects. Therefore, understanding the effects of MPD on the prefrontal cortex (PFC), a brain area involved in higher cortical processing such as executive function, language, planning, and attention regulation, is of particular importance. The goal of this study is to investigate the effects of acute and chronic dose-response characteristics following MPD exposure on both the PFC neuronal population and behavioral activity in freely behaving animals implanted previously with permanent electrodes within the PFC...
January 19, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28106225/co-immobilization-of-glucose-oxidase-and-catalase-for-enhancing-the-performance-of-a-membraneless-glucose-biofuel-cell-operated-under-physiological-conditions
#19
Marcelinus Christwardana, Yongjin Chung, Yongchai Kwon
Glucose oxidase (GOx)-catalase co-immobilized catalyst (CNT/PEI/(GOx-Cat)) was synthesized, and its catalytic activity and electrical performance were investigated and compared, whereas the amount of immobilized catalase was optochemically inspected by chemiluminescence (CL) assay. With the characterizations, it was confirmed that the catalase was well immobilized on the CNT/PEI surface, whereas both the GOx and catalase play their roles well in the catalyst. According to the measurements of the current density peak of the flavin adenine dinucleotide (FAD) redox reaction, electron transfer rate, Michaelis-Menten constants and sensitivity, CNT/PEI/(GOx-Cat) shows the best values, and this is attributed to the excellent catalytic activity of GOx and the H2O2 decomposition capability of the catalase...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28101719/in-patients-with-a-soft-pancreas-a-thick-parenchyma-a-small-duct-and-fatty-infiltration-are-significant-risks-for-pancreatic-fistula-after-pancreaticoduodenectomy
#20
Motokazu Sugimoto, Shinichiro Takahashi, Motohiro Kojima, Tatsushi Kobayashi, Naoto Gotohda, Masaru Konishi
BACKGROUND: This study sought to characterize soft and hard pancreatic textures radiologically and histologically, and to identify specific risks in a soft pancreas associated with postoperative pancreatic fistula (POPF) formation after pancreaticoduodenectomy (PD). METHODS: Consecutive 145 patients who underwent PD at a single institution between January 2010 and May 2013 were studied. Pancreatic consistency was intraoperatively judged as soft or hard. Pancreatic configuration was assessed using preoperative CT...
January 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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