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https://www.readbyqxmd.com/read/27900729/radical-resection-of-t1-pancreatic-adenocarcinoma-with-a-pseudocyst-of-the-tail-due-to-acute-obstructive-pancreatitis-report-of-a-case
#1
Yuki Fujiwara, Fumitake Suzuki, Masaru Kanehira, Yasuro Futagawa, Tomoyoshi Okamoto, Katsuhiko Yanaga
A 53-year-old male visited his primary physician for epigastric and back pain. Abdominal-enhanced computed tomography (CT) revealed a simple cyst of the pancreatic tail attached to the stomach. A distal main pancreatic duct (MPD) was clearly dilated, but no pancreatic tumor was identified around the stenosis of MPD by CT scan and magnetic resonance cholangiopancreatography (MRCP). Endoscopic retrograde pancreatography (ERP) revealed stenosis and distal dilation of the MPD located between the body and tail of the pancreas...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27889580/methylphenidate-modulates-dorsal-raphe-neuronal-activity-behavioral-and-neuronal-recordings-from-adolescent-rats
#2
Holly Whitt, Natasha Kharas, Nachum Dafny
Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects of MPD may be mediated in part by alterations in serotonin transmission. This study aimed to investigate the role of the dorsal raphe (DR) nucleus, one of the major sources of serotonergic innervation in the mammalian brain, in the response to MPD exposure...
November 23, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27889476/yeast-and-carbon-nanotube-based-biocatalyst-developed-by-synergetic-effects-of-covalent-bonding-and-hydrophobic-interaction-for-performance-enhancement-of-membraneless-microbial-fuel-cell
#3
Marcelinus Christwardana, Yongchai Kwon
Membraneless microbial fuel cell (MFC) employing new microbial catalyst formed as yeast cultivated from Saccharomyces cerevisiae and carbon nanotube (yeast/CNT) is suggested. To analyze its catalytic activity and performance and stability of MFC, several characterizations are performed. According to the characterizations, the catalyst shows excellent catalytic activities by facile transfer of electrons via reactions of NAD, FAD, cytochrome c and cytochrome a3, while it induces high maximum power density (MPD) (344mW·m(-2))...
November 16, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27867560/should-primary-tumor-be-resected-for-non-small-cell-lung-cancer-with-malignant-pleural-disease-unexpectedly-found-during-operation-a-systemic-review-and-meta-analysis
#4
Yuyang Xu, Nan Chen, Zihuai Wang, Yingyi Zhang, Jiandong Mei, Chengwu Liu, Lunxu Liu
BACKGROUND: Non-small cell lung cancer (NSCLC) with malignant pleural disease (MPD) was considered to be contraindication for surgery, but sometimes MPD was unexpectedly found intraoperatively. There was no consensus on the role of surgical intervention on the primary tumor in patients with MPD. The object of this research was to assess whether exairesis of primary tumor could prolong survival time. METHODS: A systemic research of literature was performed on the databases of PubMed, Embase and Web of Science...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27853928/d1-and-d2-specific-dopamine-antagonist-modulate-the-caudate-nucleus-neuronal-responses-to-chronic-methylphenidate-exposure
#5
Sidish Venkataraman, Catherine Claussen, Nachum Dafny
The psychostimulant, methylphenidate (MPD), is the first line treatment as a pharmacotherapy to treat behavioral disorders such as attention deficit hyperactivity disorder (ADHD). MPD is commonly misused in non-ADHD (normal) youth and young adults both as a recreational drug and for cognitive enhancing effects to improve their grades. MPD is known to act on the reward circuit; including the caudate nucleus (CN). The CN is comprised of medium spiny neurons containing largely dopamine (DA) D1 and D2 receptors...
November 16, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27853645/promoter-methylation-of-the-immune-checkpoint-receptor-pd-1-pdcd1-is-an-independent-prognostic-biomarker-for-biochemical-recurrence-free-survival-in-prostate-cancer-patients-following-radical-prostatectomy
#6
Diane Goltz, Heidrun Gevensleben, Jörn Dietrich, Jörg Ellinger, Jennifer Landsberg, Glen Kristiansen, Dimo Dietrich
Biomarkers that facilitate the prediction of disease recurrence in prostate cancer (PCa) may enable physicians to personalize treatment for individual patients. In the current study, PD-1 (PDCD1) promoter methylation was assessed in a cohort of 498 PCa patients included in The Cancer Genome Atlas (TCGA) and a second cohort of 300 PCa cases treated at the University Hospital of Bonn. In the TCGA cohort, the PD-1 promoter was significantly hypermethylated in carcinomas versus normal prostatic epithelium (55.5% vs...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27853644/vectorization-in-an-oncolytic-vaccinia-virus-of-an-antibody-a-fab-and-a-scfv-against-programmed-cell-death-1-pd-1-allows-their-intratumoral-delivery-and-an-improved-tumor-growth-inhibition
#7
Patricia Kleinpeter, Laetitia Fend, Christine Thioudellet, Michel Geist, Nathalie Sfrontato, Véronique Koerper, Catherine Fahrner, Doris Schmitt, Murielle Gantzer, Christelle Remy-Ziller, Renée Brandely, Dominique Villeval, Karola Rittner, Nathalie Silvestre, Philippe Erbs, Laurence Zitvogel, Eric Quéméneur, Xavier Préville, Jean-Baptiste Marchand
We report here the successful vectorization of a hamster monoclonal IgG (namely J43) recognizing the murine Programmed cell death-1 (mPD-1) in Western Reserve (WR) oncolytic vaccinia virus. Three forms of mPD-1 binders have been inserted into the virus: whole antibody (mAb), Fragment antigen-binding (Fab) or single-chain variable fragment (scFv). MAb, Fab and scFv were produced and assembled with the expected patterns in supernatants of cells infected by the recombinant viruses. The three purified mPD-1 binders were able to block the binding of mPD-1 ligand to mPD-1 in vitro...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27835597/pd-l1-promoter-methylation-is-a-prognostic-biomarker-for-biochemical-recurrence-free-survival-in-prostate-cancer-patients-following-radical-prostatectomy
#8
Heidrun Gevensleben, Emily Eva Holmes, Diane Goltz, Jörn Dietrich, Verena Sailer, Jörg Ellinger, Dimo Dietrich, Glen Kristiansen
BACKGROUND: The rapid development of programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors has generated an urgent need for biomarkers assisting the selection of patients eligible for therapy. The use of PD-L1 immunohistochemistry, which has been suggested as a predictive biomarker, however, is confounded by multiple unresolved issues. The aim of this study therefore was to quantify PD-L1 DNA methylation (mPD-L1) in prostate tissue samples and to evaluate its potential as a biomarker in prostate cancer (PCa)...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829085/assessment-of-a-revised-management-strategy-for-patients-with-intraductal-papillary-mucinous-neoplasms-involving-the-main-pancreatic-duct
#9
Motokazu Sugimoto, Irmina A Elliott, Andrew H Nguyen, Stephen Kim, V Raman Muthusamy, Rabindra Watson, O Joe Hines, David W Dawson, Howard A Reber, Timothy R Donahue
Importance: According to the 2012 International Consensus Guidelines, the diagnostic criterion of intraductal papillary mucinous neoplasms (IPMNs) involving the main duct (MD IPMNs) or the main and branch ducts (mixed IPMNs) of the pancreatic system is a main pancreatic duct (MPD) diameter of 5.0 mm or greater on computed tomography (CT) or magnetic resonance imaging (MRI). However, surgical resection is recommended for patients with an MPD diameter of 10.0 mm or greater, which is characterized as a high-risk stigma...
November 9, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27822631/pancreatic-duct-involvement-in-well-differentiated-neuroendocrine-tumors-is-an-independent-poor-prognostic-factor
#10
Yoshihide Nanno, Ippei Matsumoto, Yoh Zen, Kyoko Otani, Jun Uemura, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Keiichi Okano, Yasuyuki Suzuki, Yoshifumi Takeyama, Takumi Fukumoto, Yonson Ku
BACKGROUND: The biological behavior of well-differentiated neuroendocrine tumors of the pancreas (PNETs) is difficult to predict. This study was designed to determine whether involvement of the main pancreatic duct (MPD) serves as a poor prognostic factor for PNETs. METHODS: The involvement of the MPD in PNETs was defined as ductal stenosis inside the tumor mass associated with distal MPDs more than twofold larger in diameter than the proximal ducts. We examined the correlation between MPD involvement and other clinicopathological parameters, including nodal metastasis and recurrence-free survival, in 101 patients treated consecutively at three referral centers in Japan...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27782004/robust-dynamic-myocardial-perfusion-ct-deconvolution-for-accurate-residue-function-estimation-via-adaptive-weighted-tensor-total-variation-regularization-a-preclinical-study
#11
Dong Zeng, Changfei Gong, Zhaoying Bian, Jing Huang, Xinyu Zhang, Hua Zhang, Lijun Lu, Shanzhou Niu, Zhang Zhang, Zhengrong Liang, Qianjin Feng, Wufan Chen, Jianhua Ma
Dynamic myocardial perfusion computed tomography (MPCT) is a promising technique for quick diagnosis and risk stratification of coronary artery disease. However, one major drawback of dynamic MPCT imaging is the heavy radiation dose to patients due to its dynamic image acquisition protocol. In this work, to address this issue, we present a robust dynamic MPCT deconvolution algorithm via adaptive-weighted tensor total variation (AwTTV) regularization for accurate residue function estimation with low-mA s data acquisitions...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27769497/highly-selective-and-sensitive-detection-of-2-4-6-trinitrophenol-by-using-newly-developed-blue-green-photoluminescent-carbon-nanodots
#12
Meng Li Liu, Bin Bin Chen, Ze Xi Liu, Cheng Zhi Huang
Though many methods of detecting 2,4,6-trinitrophenol (TNP) mainly have been developed recent years, quantification of TNP in environmental matrixes still faces up to great challenges because all the nitroaromatic explosives reveal highly similar chemical structure. In the present work, we have developed a selective and sensitive method for detection of TNP by amorphous photoluminescent carbon nanodots (CNDs), which are prepared through a simple hydrothermal route using spermine and m-phenylenediamine (MPD) as precursors...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27763342/effects-of-dmso-and-glycerol-additives-on-the-property-of-polyamide-reverse-osmosis-membrane
#13
Fengjing Wu, Xiaojuan Liu, Chaktong Au
The polyamide reverse osmosis (RO) membranes were prepared through interfacial polymerization of m-phenylenediamine (MPD) and trimesoyl chloride (TMC). The use of dimethyl sulfoxide (DMSO) and glycerol as additives for the formation of thin-film composite (TFC) was investigated. We studied the effect of DMSO and glycerol addition on membrane property and RO performance. Microscopic morphology was examined by atomic force microscopy and scanning electron microscopy. The surface hydrophilicity was characterized on the basis of water contact angle and surface solid-liquid interfacial free energy (-ΔGSL)...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27756251/analysis-of-the-kinetics-of-the-parathyroid-hormone-and-of-associated-patient-outcomes-in-a-cohort-of-haemodialysis-patients
#14
Guillaume Jean, Jean-Claude Souberbielle, Eric Zaoui, Christie Lorriaux, Jean-Marc Hurot, Brice Mayor, Patrik Deleaval, Manolie Mehdi, Charles Chazot
BACKGROUND: Observational studies have recently associated a decrease in serum parathyroid hormone (PTH) level with a higher rate of mortality among hemodialysis (HD) patients. Decreases in PTH level can result from medical intervention (MPD) and surgical parathyroidectomy (PTX), or may occur spontaneously, usually associated with an underlying malnutrition-inflammation syndrome (SPD). The aim of our study was to prospectively identify the incidence of decreases in PTH level in a cohort of HD patients and the frequency distribution of the different causes (MPD, PTX and SPD), as well as to evaluate the survival outcomes for each PTH group (MPD, PTX and SPD) compared to patients who did not experience a PTH decrease over the first 36 months of the study (NPD)...
October 18, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27742822/mirpathdb-a-new-dictionary-on-micrornas-and-target-pathways
#15
Christina Backes, Tim Kehl, Daniel Stöckel, Tobias Fehlmann, Lara Schneider, Eckart Meese, Hans-Peter Lenhof, Andreas Keller
In the last decade, miRNAs and their regulatory mechanisms have been intensively studied and many tools for the analysis of miRNAs and their targets have been developed. We previously presented a dictionary on single miRNAs and their putative target pathways. Since then, the number of miRNAs has tripled and the knowledge on miRNAs and targets has grown substantially. This, along with changes in pathway resources such as KEGG, leads to an improved understanding of miRNAs, their target genes and related pathways...
October 13, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27739409/quantitative-assessment-of-provability-of-radiation-related-cancers-considering-unavoidable-existence-of-unadjusted-risk-factors
#16
H Ogino, Y Fujimichi, M Sasaki, N Hamada, T Iwasaki, K Yoshida, T Hattori
The attribution of stochastic effects to exposure to ionizing radiation has been qualitatively discussed by introducing two distinct concepts of provability and probability. This study aims to develop a method of quantitatively assessing the provability of radiation-related cancers. To this end, the 'minimum provable dose' (MPD) was developed and applied to actual cancer mortality in Japan. The background lifetime risk of cancer mortality was calculated for the esophagus, stomach, colon, liver, lungs, skin, breasts, ovaries, bladder, and bone marrow as well as the age-specific risk coefficients reproducing those given in the 2007 Recommendations of the International Commission on Radiological Protection (ICRP)...
October 14, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27736071/geometrical-structures-of-partially-oxidized-rhodium-cluster-cations-rh6om-m-4-5-6-revealed-by-infrared-multiple-photon-dissociation-spectroscopy
#17
Kohei Koyama, Toshiaki Nagata, Satoshi Kudoh, Ken Miyajima, Douwe M M Huitema, Valeriy Chernyy, Joost M Bakker, Fumitaka Mafune
Infrared multiple photon dissociation (IR-MPD) spectra of Rh6Om+ (m = 4-10) are obtained in the 300-1000 cm-1 spectral range using the free electron laser for infrared experiments (FELIX) via dissociation of Rh6Om+ or Rh6Om+-Ar complexes. The spectra are compared with the calculated spectra of several stable geometries obtained by density functional theory (DFT) structural optimization. The spectrum for Rh6O4+ shows prominent bands at 620 and 690 cm-1, and is assigned to a capped-square pyramidal Rh atom geometry with three bridging O atoms and one O atom in a hollow site...
October 13, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27716562/the-excellent-performance-of-nest-like-oxygen-deficient-cu1-5mn1-5o4-applied-in-activated-carbon-air-cathode-microbial-fuel-cell
#18
Junjie Wang, Pei Tian, Kexun Li, Baochao Ge, Di Liu, Yi Liu, Tingting Yang, Rong Ren
This study investigated the performance of nano spinel nest-like oxygen-deficient Cu1.5Mn1.5O4 doping activated carbon (AC) as air cathode in microbial fuel cell (MFC). The Cu1.5Mn1.5O4 was synthesized via hydrothermal method and subsequent annealed. The maximum power density (MPD) of MFC with oxygen-deficient Cu1.5Mn1.5O4 modified cathode was 1928±18mWm(-2), which was 1.53 times higher than the bare cathode. The electrochemical studies showed that Cu1.5Mn1.5O4 doping AC exhibited higher kinetic activity and lower resistance...
October 1, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27713599/influence-of-tree-shape-and-evolutionary-time-scale-on-phylogenetic-diversity-metrics
#19
F Mazel, T J Davies, L Gallien, J Renaud, M Groussin, T Münkemüller, W Thuiller
During the last decades, describing, analysing and understanding the phylogenetic structure of species assemblages has been a central theme in both community ecology and macro-ecology. Among the wide variety of phylogenetic structure metrics, three have been predominant in the literature: Faith's phylogenetic diversity (PDFaith), which represents the sum of the branch lengths of the phylogenetic tree linking all species of a particular assemblage, the mean pairwise distance between all species in an assemblage (MPD) and the pairwise distance between the closest relatives in an assemblage (MNTD)...
October 2016: Ecography
https://www.readbyqxmd.com/read/27705969/non-invasive-haemodynamic-monitoring-in-pregnancy-a-comparative-study-using-ultrasound-and-bioreactance
#20
Dimuthu Vinayagam, Sophie Bowe, Elaine Sheehan, Basky Thilaganathan, Asma Khalil
BACKGROUND: Due to the importance of cardiovascular dysfunction and advances in the development and use of non-invasive cardiac output (CO) monitoring devices, there is a growing interest in their use in the obstetric population. The aim of this study was to compare two commercially available, non-invasive CO monitors in the assessment of heart rate (HR), stroke volume (SV), CO, cardiac index (CI) and total peripheral resistance (TPR) in an obstetric population. METHODS: This was a prospective, comparative study including two groups...
October 6, 2016: Fetal Diagnosis and Therapy
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