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https://www.readbyqxmd.com/read/28628155/-3d-printed-template-assisted-and-computed-tomography-image-guided-125-iodine-seed-implantation-for-supraclavicular-metastatic-tumor-a-dosimetric-study
#1
(no author information available yet)
OBJECTIVE: To compare the dosimetric data between the preoperative plans and postoperative verification in personalized 3D printed template-assisted and computed tomography (CT) image-guided 125-iodine seed implantation for supraclavicular metastatic tumor, and to evaluate the accuracy and feasibility at the dosimetry level. METHODS: A total of 14 patients with supraclavicular metastatic tumor (including 15 lesions) who received 3D printed template assisted and CT image-guided 125-iodine seed implantation in Department of Radiation Oncology of Peking University Third Hospital from January to September 2016 were enrolled...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28615331/comparison-of-the-vta-and-lc-response-to-methylphenidate-a-concomitant-behavioral-and-neuronal-study-of-adolescent-male-rats
#2
Tahseen Jalal Karim, Cruz Reyes-Vazquez, Nachum Dafny
Methylphenidate (MPD), also known as Ritalin, is a psychostimulant used to treat attention hyperactivity disorder. However, it is increasingly being misused by normal adolescents for recreation and academic advantage. Therefore, it is important to elucidate the behavioral and neurophysiological effects of MPD in normal subjects. MPD inhibits the reuptake of catecholamines, mainly found in the ventral tegmental area (VTA) and locus coeruleus (LC). The VTA and LC normally mediate attention, motivation, and drug reward behaviors...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28614441/prevalence-and-factors-associated-with-minor-psychiatric-disorders-in-hospital-housekeeping-workers
#3
Cintia da Silva Marconato, Ana Carolina de Souza Magnago, Tânia Solange Bosi de Souza Magnago, Graziele de Lima Dalmolin, Rafaela Andolhe, Juliana Petri Tavares
OBJECTIVE: Investigating the prevalence and factors associated with minor psychiatric disorders (MPDs) in Hospital housekeeping workers. METHOD: A cross-sectional study carried out in 2013 with workers from the cleaning service of a public university hospital in Rio Grande do Sul, Brazil. Data were collected through a form containing sociodemographic, occupational, habits and health variables. The Self-Reporting Questionnaire-20 was used in order to evaluate MPDs...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28613247/thin-film-nanocomposite-membrane-filled-with-metal-organic-frameworks-uio-66-and-mil-125-nanoparticles-for-water-desalination
#4
Mohammed Kadhom, Weiming Hu, Baolin Deng
Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs) nanoparticles (NPs), UiO-66 (~100 nm) and MIL-125 (~100 nm), were embedded separately into thin-film composite membranes in different weight ratios, 0%, 0.05%, 0.1%, 0.15%, 0.2%, and 0.3%. The membranes were synthesized by the interfacial polymerization (IP) of m-phenylenediamine (MPD) in aqueous solution and trimesoyl chloride (TMC) in an organic phase...
June 14, 2017: Membranes
https://www.readbyqxmd.com/read/28597193/concentrate-supplementations-of-grazing-pregnant-kalahari-red-goats-effects-on-pregnancy-variables-reproductive-performance-birth-types-and-weight-of-kids
#5
O A Oderinwale, B O Oluwatosin, O S Sowande, M N Bemji, S D Amosu, G O Sanusi
A study was conducted for 22 weeks to determine the effects of concentrate supplementations at three crude protein (CP) levels, i.e. low protein diet-LPD 12.42% CP (124.93 g day(-1)); medium protein diet-MPD 14.18% CP (145.87 g day(-1)) and high protein diet-HPD 16.35% CP (168.19 g day(-1)) on some pregnancy variables, reproductive performance, birth types and weight of kids kidded by pregnant Kalahari Red goats grazed on Chloris gayana. Thirty-three matured Kalahari Red goats of first parity within age range of 2 to 2(1)/2 years with an average body weight of 38...
June 9, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28595770/influence-of-breastfeeding-and-iron-status-on-mental-and-psychomotor-development-during-the-first-year-of-life
#6
Cristina Jardí, Carmen Hernández-Martínez, Josefa Canals, Victoria Arija, Cristina Bedmar, Núria Voltas, Núria Aranda
Breastfeeding (BF) confers numerous benefits on the developing infant in both the short and the long term including psychological development, but there are multiple other factors that must be taken into account when these relationships are studied. To analyse how breastfeeding during the first 4 months of life affects infant mental and psychomotor development (MPD) at 6 and 12 months in a group of healthy infants from a Mediterranean Spanish city considering many important potential confounds. This is a longitudinal study conducted on infants from birth until the age of 12 months...
June 5, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28594404/precision-medicine-for-hepatocelluar-carcinoma-using-molecular-pattern-diagnostics-results-from-a-preclinical-pilot-study
#7
Rahul Agarwal, Yuan Cao, Klaus Hoffmeier, Nicolas Krezdorn, Lukas Jost, Alejandro Rodriguez Meisel, Ruth Jüngling, Francesco Dituri, Serena Mancarella, Björn Rotter, Peter Winter, Gianluigi Giannelli
The aim of this study was to design a road map for personalizing cancer therapy in hepatocellular carcinoma (HCC) by using molecular pattern diagnostics. As an exploratory study, we investigated molecular patterns of tissues of two tumors from individual HCC patients, which in previous experiments had shown contrasting reactions to the phase 2 transforming growth factor beta receptor 1 inhibitor galunisertib. Cancer-driving molecular patterns encompass - inter alias - altered transcription profiles and somatic mutations in coding regions differentiating tumors from their respective peritumoral tissues and from each other...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28583378/reporting-and-methods-for-handling-missing-participant-data-for-continuous-outcomes-in-randomized-controlled-trials-a-systematic-survey
#8
REVIEW
Yuqing Zhang, Ivan D Flórez, Luis E Colunga Lozano, Fazila Abu Bakar Aloweni, Sean Alexander Kennedy, Aihua Li, Samantha Craigie, Shiyuan Zhang, Arnav Agarwal, Luciane C Lopes, Tahira Devji, Wojtek Wiercioch, John J Riva, Mengxiao Wang, Xuejing Jin, Yutong Fei, Paul Alexander, Gian Paolo Morgano, Yuan Zhang, Alonso Carrasco-Labra, Lara A Kahale, Elie A Akl, Holger J Schünemann, Lehana Thabane, Gordon Guyatt
OBJECTIVE: To assess analytic approaches randomized trial (RCT) authors use to address missing participant data (MPD) for patient-important continuous outcomes. STUDY DESIGN AND SETTINGS: We conducted a systematic survey of RCTs published in 2014 in the core clinical journals that reported at least one patient-important outcome analyzed as a continuous variable. RESULT: Among 200 studies, 187 (93.5%) trials explicitly reported whether MPD occurred...
June 2, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28579378/reporting-quality-and-optimal-methods-of-handling-participants-with-missing-outcome-data-for-continuous-outcomes-in-randomized-controlled-trials-a-systematic-survey-of-the-methods-literature
#9
REVIEW
Yuqing Zhang, Akram Alyass, Thuva Vanniyasingam, Behnam Sadeghirad, Iván D Flórez, Sathish Chandra Pichika, Sean Alexander Kennedy, Ulviya Abdulkarimova, Yuan Zhang, Tzvia Iljon, Gian Paolo Morgano, Luis E Colunga Lozano, Fazila Abu Bakar Aloweni, Luciane C Lopes, Juan José Yepes-Nuñez, Yutong Fei, Li Wang, Lara A Kahale, David Meyre, Elie A Akl, Lehana Thabane, Gordon Guyatt
OBJECTIVE: To conduct 1) a systematic survey of the reporting quality of simulation studies dealing with how to handle missing participant data (MPD) in randomized control trials and 2) summarize the findings of these studies. STUDY DESIGN AND SETTINGS: We included simulation studies comparing statistical methods dealing with continuous MPD in RCTs addressing bias, precision, coverage, accuracy, power, type I error and overall ranking. For the reporting of simulation studies, we adapted previously developed criteria for reporting quality and applied them to eligible studies...
June 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28567485/mucinous-nonneoplastic-cyst-of-the-pancreas-ct-and-mri-appearances
#10
Kousei Ishigami, Akihiro Nishie, Naoki Mochidome, Yoshiki Asayama, Yasuhiro Ushijima, Daisuke Kakihara, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Yoshihiro Miyasaka, Tomoyuki Hida, Tomoharu Yoshizumi, Hiroshi Honda
PURPOSE: The purpose of this retrospective study was to evaluate imaging features of mucinous nonneoplastic cyst (MNNC) of the pancreas. MATERIALS AND METHODS: Three (0.9%) patients with MNNC of the pancreas were found in 335 surgically resected pancreatic cystic lesions. Three MDCT and two MRI/MRCP studies were retrospectively reviewed. RESULTS: Three cases of MNNC were found in the pancreatic neck, body, and tail, respectively. All the three cases were multilocular without communication with the main pancreatic duct (MPD), although upstream MPD dilatation was seen in two of the three cases...
May 31, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28544816/analytical-characterization-of-three-cathinone-derivatives-4-mpd-4%C3%A2-f-php-and-bk-epdp-purchased-as-bulk-powder-from-online-vendors
#11
Orapan Apirakkan, Anca Frinculescu, Trevor Shine, Mark C Parkin, Agostino Cilibrizzi, Nunzianda Frascione, Vincenzo Abbate
Novel emerging drugs of abuse, also referred as new psychoactive substances (NPS), constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One of such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28543995/the-effects-of-restoring-logged-tropical-forests-on-avian-phylogenetic-and-functional-diversity
#12
Cindy C P Cosset, David P Edwards
Selective logging is the most prevalent land-use change in the tropics. Despite the resulting degradation of forest structure, selectively logged forests still harbour a substantial amount of biodiversity leading to suggestions that their protection is the next best alternative to conserving primary, old-growth forests. Restoring carbon stocks under Reducing Emissions from Deforestation and Forest Degradation (REDD+) schemes is a potential method for obtaining funding to protect logged forests, via enrichment planting and liberation cutting of vines...
May 24, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28538461/dnp-preparation-in-supporting-critical-skills-for-magnet%C3%A2-program-directors
#13
Sarah Lackey
Magnet® organizations are required to identify a Magnet program director (MPD), who plays a critical role in attaining and maintaining Magnet designation. The evidence is sparse related to qualifications or recommended educational levels of those assuming an MPD role. In this article, the author discusses how one of the DNP Essentials, clinical scholarship and the use of analytical methods for evidence-based practice, is reported to prepare nurses for the MPD role.
June 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28531356/spin-polarization-transfer-from-a-photogenerated-radical-ion-pair-to-a-stable-radical-controlled-by-charge-recombination
#14
Noah E Horwitz, Brian T Phelan, Jordan N Nelson, Catherine M Mauck, Matthew D Krzyaniak, Michael R Wasielewski
Photoexcitation of electron donor-acceptor molecules frequently produces radical ion pairs with well-defined initial spin-polarized states that have attracted significant interest for spintronics. Transfer of this initial spin polarization to a stable radical is predicted to depend on the rates of the radical ion pair recombination reactions, but this prediction has not been tested experimentally. In this study, a stable radical/electron donor/chromophore/electron acceptor molecule, BDPA(•)-mPD-ANI-NDI, where BDPA(•) is α,γ-bisdiphenylene-β-phenylallyl, mPD is m-phenylenediamine, ANI is 4-aminonaphthalene-1,8-dicarboximide, and NDI is naphthalene-1,4:5,8-bis(dicarboximide), was synthesized...
June 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28526350/designing-novel-bioconjugates-of-hydroxyethyl-cellulose-and-salicylates-for-potential-pharmaceutical-and-pharmacological-applications
#15
Khawar Abbas, Muhammad Amin, Muhammad Ajaz Hussain, Muhammad Sher, Syed Nasir Abbas Bukhari, Ibrahim Jantan, Kevin J Edgar
This deals with fabrication of macromolecular prodrugs (MPDs) of salicylic acid (SA) and aspirin (ASP) based on a hydrophilic cellulose ether, hydroxyethyl cellulose (HEC). Degrees of substitution (DS) of SA and ASP per HEC repeating unit (HEC-RU) were achieved ranging from 0.60 to 2.18 and 0.53 to1.50, respectively. The amphiphilic HEC-SA conjugate 2 assembled into nanowire-like structures, while HEC-ASP conjugate 6 formed nanoparticles (diameter 300-00nm) at a water/DMSO interface. After oral administration in rabbit models, conjugates 2 and 6 showed plasma half-life of 6...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28509543/exploring-the-gas-phase-activation-and-reactivity-of-a-ruthenium-transfer-hydrogenation-catalyst-by-experiment-and-theory-in-concert
#16
Fabian S Menges, Johannes Lang, Yevgeniy Nosenko, Christian Kerner, Maximilian Gaffga, Leila Taghizadeh Ghoochany, Werner R Thiel, Christoph Riehn, Gereon Niedner-Schatteburg
This study elucidates structures, activation barriers, and the gas-phase reactivity of cationic ruthenium transfer hydrogenation catalysts of the structural type [(η(6)-cym)RuX(pympyr)](+). In these complexes, the central ruthenium(+II) ion is coordinated to an η(6)-bound p-cymene (η(6)-cym), a bidentate 2-R-4-(2-pyridinyl)pyrimidine ligand (pympyr) with R = NH2 or N(CH3)2, and an anion X = I(-), Br(-), Cl(-), or CF3SO3(-). We present infrared multiple-photon dissociation (IR-MPD) spectra of precursors (before HCl loss) and of activated complexes (after HCl loss), which elucidates C-H activation as the key step in the activation mechanism...
June 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28506431/usefulness-of-three-dimensional-magnetic-resonance-cholangiopancreatography-with-partial-maximum-intensity-projection-for-diagnosing-autoimmune-pancreatitis
#17
Shin Yanagisawa, Yasunari Fujinaga, Takayuki Watanabe, Masahiro Maruyama, Takashi Muraki, Masaaki Takahashi, Akira Fujita, Sachie Fujita, Masahiro Kurozumi, Kazuhiko Ueda, Hideaki Hamano, Shigeyuki Kawa, Masumi Kadoya
PURPOSE: To compare three-dimensional magnetic resonance cholangiopancreatography (MRCP) with/without partial maximum intensity projection (MIP) and endoscopic retrograde cholangiopancreatography (ERCP) in patients with autoimmune pancreatitis (AIP). MATERIALS AND METHODS: Three-dimensional MRCP and ERCP images were retrospectively analyzed in 24 patients with AIP. We evaluated the narrowing length of the main pancreatic duct (NR-MPD), multiple skipped MPD narrowing (SK-MPD), and side branches arising from the narrowed portion of the MPD (SB-MPD) using four MRCP datasets: 5 original images (MIP5), 10 original images (MIP10), all original images (full-MIP), and a combination of these three datasets (a-MIP)...
May 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28448384/cytoreductive-surgery-for-metastatic-gastrointestinal-stromal-tumors-treated-with-tyrosine-kinase-inhibitors-a-2-institutional-analysis
#18
Mark Fairweather, Vinod P Balachandran, George Z Li, Monica M Bertagnolli, Cristina Antonescu, William Tap, Samuel Singer, Ronald P DeMatteo, Chandrajit P Raut
OBJECTIVE: To refine treatment recommendations for patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs) and surgery. BACKGROUND: Early reports suggested that patients with metastatic GIST responding to TKIs treated with surgery may have favorable outcomes. However, identification of prognostic factors was limited by small cohorts. METHODS: Progression-free survival (PFS) and overall survival (OS) from time of surgery and from start of initial TKI was determined...
April 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28444792/a-computational-approach-to-study-functional-monomer-protein-molecular-interactions-to-optimize-protein-molecular-imprinting
#19
R Boroznjak, J Reut, A Tretjakov, A Lomaka, A Öpik, V Syritski
Molecular imprinting has become a promising approach for synthesis of polymeric materials having binding sites with a predetermined selectivity for a given analyte, the so-called molecularly imprinted polymers (MIPs), which can be used as artificial receptors in various application fields. Realization of binding sites in a MIP involves the formation of prepolymerization complexes between a template molecule and monomers, their subsequent polymerization, and the removal of the template. It is believed that the strength of the monomer-template interactions in the prepolymerization mixture influences directly on the quality of the binding sites in a MIP and consequently on its performance...
April 26, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28423552/enhanced-antitumor-effects-by-combining-an-il-12-anti-dna-fusion-protein-with-avelumab-an-anti-pd-l1-antibody
#20
Jonathan K Fallon, Amanda J Vandeveer, Jeffrey Schlom, John W Greiner
The combined therapeutic potential of an immunocytokine designed to deliver IL-12 to the necrotic regions of solid tumors with an anti-PD-L1 antibody that disrupts the immunosuppressive PD-1/PD-L1 axis yielded a combinatorial benefit in multiple murine tumor models. The murine version of the immunocytokine, NHS-muIL12, consists of an antibody (NHS76) recognizing DNA/DNA-histone complexes, fused with two molecules of murine IL-12 (NHS-muIL12). By its recognition of exposed DNA, NHS-muIL12 targets IL-12 to the necrotic portions of tumors; it has a longer plasma half-life and better antitumor efficacy against murine tumors than recombinant murine IL-12...
March 28, 2017: Oncotarget
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