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https://www.readbyqxmd.com/read/27908828/assessment-of-the-potential-for-host-targeted-iminosugars-uv-4-and-uv-5-activity-against-filovirus-infections-in-vitro-and-in-vivo
#1
Kelly L Warfield, Travis K Warren, Xiangguo Qiu, Jay Wells, Chad E Mire, Joan B Geisbert, Kelly S Stuthman, Nicole L Garza, Sean A Van Tongeren, Amy C Shurtleff, Krystle N Agans, Gary Wong, Michael V Callahan, Thomas W Geisbert, Brennan Klose, Urban Ramstedt, Anthony M Treston
Iminosugars are host-directed antivirals with broad-spectrum activity. The iminosugar, N-butyl-deoxynojirimycin (NB-DNJ or Miglustat(®)), is used in humans for treatment of Gaucher's disease and has mild antiviral properties. More potent analogs of NB-DNJ have been generated and have demonstrated activity against a variety of viruses including flaviviruses, influenza, herpesviruses and filoviruses. In the current study, a panel of analogs based on NB-DNJ was analyzed for activity against Ebola (EBOV) and Marburg viruses (MARV)...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27902503/bedside-placement-of-the-postpyloric-tube-in-infants
#2
Patricia Clifford, Elizabeth Ely, Lauren Heimall
BACKGROUND: Patients in the neonatal intensive care unit are a vulnerable population with specific nutritional requirements, which include increased protein and caloric needs for adequate growth. Some infants cannot tolerate gastric feeds and need to have postpyloric feeds to grow. Placement of a postpyloric tube can be done by gastric insufflation. Gastric insufflation is a technique where air is inserted into the stomach as a nasogastric tube is advanced through the pylorus to the duodenum...
November 29, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27899532/long-term-management-for-ventilator-assisted-children-in-hong-kong-2-decades-experience
#3
Shuk-Kuen Chau, Ada Wing-Yan Yung, So-Lun Lee
BACKGROUND: The population of children receiving long-term mechanical ventilation is growing worldwide, but only limited data exist in Asian regions. The objective of the study was to review the management of these children in Hong Kong over the past 2 decades. METHODS: This was a retrospective cohort study. Hospital records from subjects receiving mechanical ventilation for >3 months were retrieved. Demographic characteristics and medical information of subjects (≤21 y old) under the care of the ventilator program at the Duchess of Kent Children's Hospital between 1997 and 2015 were reviewed...
November 29, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27898998/nutritional-supplementation-for-hip-fracture-aftercare-in-older-people
#4
REVIEW
Alison Avenell, Toby O Smith, James P Curtain, Jenson Cs Mak, Phyo K Myint
BACKGROUND: Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is an update of a Cochrane review first published in 2000, and previously updated in 2010. OBJECTIVES: To review the effects (benefits and harms) of nutritional interventions in older people recovering from hip fracture. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, CENTRAL, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, Embase, CAB Abstracts, CINAHL, trial registers and reference lists...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27898951/intrauterine-growth-restricted-piglets-have-similar-gastric-emptying-rates-but-lower-rectal-temperatures-and-altered-blood-values-when-compared-with-normal-weight-piglets-at-birth
#5
C Amdi, M V Klarlund, J Hales, T Thymann, C F Hansen
Intrauterine growth-restricted (IUGR) piglets have lower survival rates and are more likely to have empty stomachs 24 h after birth than normal piglets. Although hypoglycemia may result from low colostrum intake per se, it is not known if slow gastric emptying may be an additional risk factor for poor immunization and glucose absorption in IUGR piglets. It is estimated that IUGR piglets consume less colostrum per kilogram BW than normal-weight piglets within the first 24 h, which could be due to a slower gastric emptying rate and a compromised energy metabolism...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898295/prophylactic-feeding-tubes-in-head-and-neck-cancers-318
#6
Samuel Hardy, Krista Haas, Vincent J Vanston, Mark Angelo
No abstract text is available yet for this article.
December 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27895228/differences-in-durability-dislodgement-and-other-complications-with-use-of-low-profile-nonballoon-gastrostomy-tubes-in-children
#7
Temara Hajjat, Riad M Rahhal
BACKGROUND: Nonballoon low-profile gastrostomy tubes (GTs) are used for enteral nutrition support in a subset of pediatric patients with feeding difficulties when use of balloon GTs is problematic. Different nonballoon low-profile tube types are available, but comparative studies are lacking. MATERIALS AND METHODS: This was a retrospective cohort study comparing complications and outcomes between different low-profile nonballoon GTs at a pediatric tertiary care center over 10 years...
November 28, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27891281/septooptic-dysplasia-with-an-associated-arachnoid-cyst
#8
Skyler V McLaurin-Jiang, Julie K Wood, David F Crudo
A 4-week-old male infant presented with hypothermia, hypoglycemia, and hyperbilirubinemia. His medical history was remarkable for hydrocephalus secondary to an arachnoid cyst, intermittent hypoglycemia, hypothermia, and poor feeding requiring nasogastric tube for nutrition. Physical exam revealed retrognathia, mild hypotonia, micropenis, and clinodactyly. Ophthalmologic exam demonstrated bilateral optic nerve hypoplasia (ONH). Laboratory data confirmed inadequate cortisol and growth hormone response to hypoglycemia, a low thyroxine level, and direct hyperbilirubinemia...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27882641/hydrogen-permeable-tubular-membrane-reactor-promoting-conversion-and-product-selectivity-for-non-oxidative-activation-of-methane-over-an-fe%C3%A2-sio2-catalyst
#9
Mann Sakbodin, Yiqing Wu, Su Cheun Oh, Eric D Wachsman, Dongxia Liu
Non-oxidative methane conversion over Fe©SiO2 catalyst was studied for the first time in a hydrogen (H2 ) permeable tubular membrane reactor. The membrane reactor is composed of a mixed ionic-electronic SrCe0.7 Zr0.2 Eu0.1 O3-δ thin film (≈20 μm) supported on the outer surface of a one-end capped porous SrCe0.8 Zr0.2 O3-δ tube. Significant improvement in CH4 conversion was achieved upon H2 removal from the membrane reactor compared to that in a fixed-bed reactor. The Fe©SiO2 catalyst in the H2 permeable membrane reactor demonstrated a stable ≈30 % C2+ single-pass yield, with up to 30 % CH4 conversion and 99 % selectivity to C2 (ethylene and acetylene) and aromatic (benzene and naphthalene) products, at the tested conditions...
November 24, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27879283/infant-videofluoroscopic-swallow-study-testing-swallowing-interventions-and-future-acute-respiratory-illness
#10
Eric R Coon, Rajendu Srivastava, Gregory J Stoddard, Sheena Reilly, Christopher G Maloney, Susan L Bratton
OBJECTIVES: Tube feedings are commonly prescribed to infants with swallowing abnormalities detected by videofluoroscopic swallow study (VFSS), but there are no studies demonstrating efficacy of these interventions to reduce risk of acute respiratory illness (ARI). We sought to measure the association between swallowing interventions and future ARI, among VFSS-tested infants. METHODS: Retrospective cohort of all infants (<12 months) tested with VFSS at a children's hospital between January 1, 2010, and January 1, 2012...
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27878755/double-pigtail-stent-insertion-for-healing-of-leaks-following-roux-en-y-gastric-bypass-our-experience-with-videos
#11
Gianfranco Donatelli, Jean-Loup Dumont, Parag Dhumane, Stavros Dritsas, Thierry Tuszynski, Bertrand Marie Vergeau, Bruno Meduri
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is complicated by a leak in 0-4.3% of cases. Treatment by fully covered stents has been reported to be associated with some life-threatening complications. We report our experience of insertion of double pigtail stents. METHODS: Thirty-three patients (20M, 43 years-20/65), presenting with a leak at an average of 10 days after RYGB (4-35), were treated by double pigtail stent insertion and a nasojejunal feeding tube. Sixty percent of these patients had undergone surgical drainage prior to stenting for control of sepsis...
November 23, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27873512/antimicrobial-resistance-and-clinical-outcomes-in-nursing-home-acquired-pneumonia-compared-to-community-acquired-pneumonia
#12
Yun Seong Kang, Soo Ryeong Ryoo, Seung Joo Byun, Yun Jeong Jeong, Jin Young Oh, Young Soon Yoon
PURPOSE: Patients with nursing home-acquired pneumonia (NHAP) should be treated as hospital-acquired pneumonia (HAP) according to guidelines published in 2005. However, controversy still exists on whether the high mortality of NHAP results from multidrug resistant pathogens or underlying disease. We aimed to outline differences and factors contributing to mortality between NHAP and community-acquired pneumonia (CAP) patients. MATERIALS AND METHODS: We retrospectively evaluated patients aged 65 years or older with either CAP or NHAP from 2008 to 2014...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27869147/interplay-between-vegf-and-nrf2-regulates-angiogenesis-due-to-intracranial-venous-hypertension
#13
Liwen Li, Hao Pan, Handong Wang, Xiang Li, Xiaomin Bu, Qiang Wang, Yongyue Gao, Guodao Wen, Yali Zhou, Zixiang Cong, Youqing Yang, Chao Tang, Zhengwei Liu
Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with the HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related factor 2(Nrf2) significantly influences angiogenesis; however, the interplay between Nrf2 and VEGF under VH in brain AVMs remains unclear. Therefore, our study aimed to investigate the interplay between Nrf2 and VEGF due to VH in brain AVMs. Immunohistochemistry indicated that Nrf2 and VEGF were highly expressed in human brain AVM tissues...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27868158/growth-and-prevalence-of-feeding-difficulties-in-children-with-robin-sequence-a-retrospective-cohort-study
#14
Emma C Paes, Iris A C de Vries, Wouter M Penris, Karlijn H Hanny, Selma W Lavrijsen, Elselien K van Leerdam, Maaike M Rademaker, Esther S Veldhoen, Rene M J C Eijkemans, Moshe Kon, Corstiaan C Breugem
OBJECTIVES: In addition to breathing problems, patients with Robin sequence (RS) often encounter feeding difficulties (FD). Data regarding the occurrence of FD and possible influencing factors are scarce. The study aim was to elucidate these factors to improve treatment strategies. MATERIAL AND METHODS: A retrospective comparative cohort study was conducted, consisting of 69 infants diagnosed with both RS and a cleft palate and 64 isolated cleft palate only (iCPO) infants...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27863719/utility-of-feeding-jejunostomy-tubes-in-pancreaticoduodenectomy
#15
Hussein E Waliye, G Paul Wright, Caitlin McCarthy, Jared Johnson, Alex Scales, Andrea Wolf, Mathew Chung
BACKGROUND: Routine placement of jejunostomy tubes (JT) during pancreaticoduodenectomy (PD) is controversial. METHODS: A retrospective chart review of patients undergoing PD from 1/1/08 through 12/31/14 was performed. The patients were divided into groups by placement of JT. Outcome measures were 90-day morbidity, 90-day mortality, length of stay, rate of delayed gastric emptying (DGE), and JT-specific complications. RESULTS: 256 patients were included...
November 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27857647/nutrition-chez-le-br%C3%A3-l%C3%A3
#16
G Perro
Nutrition is a challenge for burn patients. Emphasized points are early enteral amounts by means of a naso-gastric tube, semi-recumbent position > 30°, gastro-intestinal survey improved by kinetics, weight evolution, nutritional amounts assessment to prevent proteino-energetic deficiency. Feeding is difficult with children, as with seniors often associating a preexisting starvation. Nutritional supplements are useful in medium severity patients. For overweight patients, hypo caloric and hyperprotidic diet is the better choice...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27855671/giant-duodenal-ulcers-after-neurosurgery-for-brainstem-tumors-that-required-reoperation-for-gastric-disconnection-a-report-of-two-cases
#17
Chihoko Nobori, Kenjiro Kimura, Go Ohira, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Tanaka, Kentaro Naito, Toshihiro Takami, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Despite the efficacy of pharmacotherapy for gastrointestinal ulcers, severe cases of bleeding or perforation due to gastrointestinal ulcers still occur. Giant duodenal ulcer perforation is an uncommon but difficult-to-manage pathology with a high mortality rate. We report two cases of giant duodenal ulcer perforation after neurosurgery for brainstem tumors that needed reoperation for gastric disconnection because of postoperative leakage and bleeding. CASE PRESENTATION: Both cases had undergone neurosurgery for brainstem tumors, and the patients were in a shock state for several days with peritonitis due to giant duodenal perforation...
November 17, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27855471/the-pharyngostomy-tube-indications-technique-efficacy-and-safety-in-modern-surgical-practice
#18
Rafael Garza-Castillon, Jonathan Berger, Rafael Andrade, Eitan Podgaetz
Background Long-term nasogastric tubes are uncomfortable and associated with complications such as impairment with speech and swallowing, septum trauma, epistaxis, alar necrosis, and intubation of the trachea among others. Pharyngostomy tubes (PTs) are an alternative for prolonged enteral feeding, transluminal drainage of collections, and gastric decompression in patients with an intestinal obstruction and an inoperable abdomen. Patients and Methods This is a retrospective analysis of patients who had a PT placed at our institution from May 2005 to March 2015...
November 17, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27853378/benefit-of-percutaneous-endoscopic-gastrostomy-in-patients-undergoing-definitive-chemoradiotherapy-for-locally-advanced-nasopharyngeal-carcinoma
#19
Yun Xu, Qiaojuan Guo, Jin Lin, Bijuan Chen, Jiangmei Wen, Tianzhu Lu, Yuanji Xu, Mingwei Zhang, Jianji Pan, Shaojun Lin
BACKGROUND AND AIM: To evaluate the impact of percutaneous endoscopic gastrostomy (PEG) tube on nutritional status, treatment-related toxicity, and treatment tolerance in patients with locally advanced nasopharyngeal carcinoma (NPC) who underwent chemoradiotherapy. PATIENTS AND METHODS: We enrolled 133 consecutive non-metastatic NPC (III/IV stage) patients, who were treated with prophylactic PEG feeding before the initiation of concurrent chemoradiotherapy (CCRT) between June 1, 2010 and June 30, 2014...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27853250/labeling-and-analysis-of-chicken-taste-buds-using-molecular-markers-in-oral-epithelial-sheets
#20
Prasangi Rajapaksha, Zhonghou Wang, Nandakumar Venkatesan, Kayvan F Tehrani, Jason Payne, Raymond L Swetenburg, Fuminori Kawabata, Shoji Tabata, Luke J Mortensen, Steven L Stice, Robert Beckstead, Hong-Xiang Liu
In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in oral epithelial sheets using the molecular markers Vimentin and α-Gustducin. Immediate tissue fixation following incubation with sub-epithelially injected proteases enabled us to peel off whole epithelial sheets, leaving the shape and integrity of the tissue intact...
November 17, 2016: Scientific Reports
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