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Clinical usefullness

Philippe Codron, Arnaud Chevrollier, Mariame Selma Kane, Andoni Echaniz-Laguna, Philippe Latour, Pascal Reynier, Dominique Bonneau, Christophe Verny, Vincent Procaccio, Guy Lenaers, Julien Cassereau
Charcot-Marie-Tooth type 2A disease (CMT2A) is an inherited peripheral neuropathy mainly caused by mutations in the MFN2 gene coding for the mitochondrial fusion protein Mitofusin 2. Although the disease is mainly inherited in a dominant fashion, few cases of early-onset autosomal recessive CMT2A (AR-CMT2A) have been reported in recent years. In this study, we characterized the structure of mitochondrial network in cultured primary fibroblasts obtained from AR-CMT2A family members. The patient-derived cells showed an increase of the mitochondrial fusion with large connected networks and an increase of the mitochondrial volume...
October 5, 2016: Journal of the Peripheral Nervous System: JPNS
Dennis C Liotta, George R Painter
The HIV/AIDS epidemic, which was first reported on in 1981, progressed in just 10 years to a disease afflicting 10 million people worldwide including 1 million in the US. In 1987, AZT was approved for treating HIV/AIDS. Unfortunately, its clinical usefullness was severly limited by associated toxicities and the emergence of resistance. Three other drugs that were approved in the early 1990s suffered from similar liabilities. In 1990, the Liotta group at Emory University developed a highly diastereoselective synthesis of racemic 3'-thia-2',3'-dideoxycytidine and 3'-thia-2',3'-5-fluorodideoxycytidine and demonstrated that these compounds exhibited excellent anti-HIV activity with no apparent cytotoxicity...
October 5, 2016: Accounts of Chemical Research
Annemie Prové, Luc Dirix
Neratinib is an orally available, pan-HER inhibitor with clinical activity in patients with HER2-amplified and HER2-mutated breast cancer. Areas Covered. A summary of publically available and relevant clinical data on neratinib. Expert Opinion. Neratinib (N) is clearly distinct from lapatinib (L), a difference based on its broad anti-HER effect, its covalent target binding and its toxicity profile. The main toxicity of neratinib is gastro-intestinal and is essentially limited to diarrhea. Although not directly compared with single agent lapatinib, skin toxicity is much less pronounced with N...
October 3, 2016: Expert Opinion on Pharmacotherapy
Erman Ceyhan, Onder Murat Delialioglu, Kenan Bayrakci, Bulent Daglar, Alper Deveci, Ugur Gunel
AIM: The aim of the study was to devolop a new equipment for the assesment of the flexibility of the spine in different forces. This new system should give a different perspective to the AIS for the selection of fusion levels and surgical success. MATERIAL AND METHODS: Eighteen patients suffering from AIS who were scheduled to undergo posterior instrumented spinal fusion in our clinic were recruided in this study. The Electronic Traction Table (ETT) which was designed in our clinic was used to evaluate the radiogical and clinical parameters of the spine...
December 7, 2015: Turkish Neurosurgery
Fatma Tülin Kayhan, Selçuk Güneş, Arzu Karaman Koç, Ayşe Pelin Yiğider, Kamil Hakan Kaya
OBJECTIVES: Laryngoceles are air-filled sacs which communicate with the laryngeal lumen. When filled with mucus or pus, they are called laryngomucoceles and laryngopyoceles, respectively. Transoral robotic surgery (TORS) is a new and remarkable technique that expands its usefullness in otorhinolaryngology. Conventional treatments for laryngoceles were previously performed using external approaches, with aesthetically unfavorable and less function-sparing results. Transoral laser microsurgical approaches for laryngoceles were seldom reported...
June 2016: Journal of Craniofacial Surgery
Antoine Simon, Mohamed Nassef, Bastien Rigaud, Guillaume Cazoulat, Joël Castelli, Caroline Lafond, Oscar Acosta, Pascal Haigron, Renaud de Crevoisier
Adaptive radiation therapy (ART) is based on the optimization of the treatment plan during the treatment delivery to compensate for anatomical deformations. Deformable Image Registration (DIR) then constitutes a key step in order to analyze the huge amount of daily or weekly images to provide clinically usefull information. Two main applications of DIR have been developped in ART: delineation propagation and dose accumulation. If delineation propagation is well validated and transfered in the clinic, some challenges remain to address for dose accumulation...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Gregory R Lisciandro
OBJECTIVE: To evaluate the clinical usefulness of the diaphragmatico-hepatic (DH) view of the abdominal and thoracic focused assessment with sonography for triage (AFAST/TFAST) in detecting pericardial effusion (PE) in dogs. DESIGN: Retrospective case series from 2011 to 2012. SETTING: Private practice emergency and critical care hospital. ANIMALS: Twenty-four dogs with PE diagnosed by FAST. INTERVENTIONS: None...
January 2016: Journal of Veterinary Emergency and Critical Care
Giuseppe Tavormina
The knowledge of the clinical features of the mixed states and of the symptoms of the "mixity" of mood disorders is crucial: to mis-diagnose or mis-treat patients with these symptoms may increase the suicide risk and make worse the evolution of mood disorders. The rating scale "G.T. MSRS" has been designed to improve the clinical effectiveness of both psychiatrists and GPs by enabling them to make an early "general" diagnosis of mixed states. This study presents some cases in which the "G.T. MSRS" scale has been used, in order to demonstrate its usefullness...
September 2015: Psychiatria Danubina
Luca Mezzetto, Lorenzo Scorsone, Rosario Pacca, Giovanni Puppini, Simone Perandini, Gian Franco Veraldi
BACKGROUND: Autologous saphenous vein is considered the gold standard conduit in the femoral-popliteal revascularization for popliteal artery aneurysms (PAAs). In several cases, it may be absent or unsuitable for length or diameter and so it may be considered unfit for a conduit. In such patients, a synthetic graft or the endovascular correction can be useful, but results are controversial. In this retrospective case series, we have analyzed the safety and efficacy of the cryopreserved homograft (CHg) as a conduit in the PAA revascularization...
August 2015: Annals of Vascular Surgery
Gordana M Mumović
BACKGROUND/AIM: After external partial laryngectomias, videostroborscopy is very usefull in evaluation of postoperative phonatory mehanisms showing the "slow motion" of the vibrations of the remaining laryngeal structures. The aim of this paper was to compare the videostroboscopic characteristics of the vibration and to establish the differences in the phonation mechanisms depending on the type of external partial laryngectomy performed. METHODS: This prospective study was conducted during the period 2003-2009 at the Ear, Nose and Throat Clinic, Clinical Center of Vojvodina, Novi Sad, including 99 patients with laryngeal carcinoma, treated with open surgical approach using different types of vertical and horizontal partial laryngectomy...
January 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Anna Zubilewicz, Joanna Dolar-Szczasny, Ewa Rakowska, Jerzy Mackiewicz
PURPOSE: We describe a case of choroidal folds coexisting with ethmoidal myxoma and the evolution of folds after tumor excision. Choroidal folds can occure in the case of intraorbital pathology. Optical coherence tomography is usefull in diagnosis and monitoring of these folds. MATERIAL AND METHODS: 45 years old woman was reffered to our clinic because of visal disturbances in her right eye. Visual acuity of right eye was 0.5, of the left eye 1.0. Intraocular pressure of both eyes was within normal limits...
2013: Klinika Oczna
Erhan Tenekecioglu, Fahriye Vatansever Agca, Kemal Karaagac, Ozlem Arican Ozluk, Tezcan Peker, Mustafa Kuzeytemiz, Muhammed Senturk, Mustafa Yılmaz
Abstract The onset of AF results in a significant increase in mortality rates and morbidity in hypertensive patients and this rhythm disorder exposes patients to a significantly increased risk of cerebral or peripheral embolisms. Tissue Doppler imaging was found to be useful in early detection of myocardial dysfunction in several diseases. It was shown that tissue Doppler analysis of the walls of the left atrial appendage (LAA) can give accurate information about the function of the LAA in hypertensive patients...
2014: Clinical and Experimental Hypertension: CHE
Maria Antonietta Mazzei, Nevada Cioffi Squitieri, Susanna Guerrini, Amato Antonio Stabile Ianora, Lucio Cagini, Luca Macarini, Melchiore Giganti, Luca Volterrani
Acute diverticulitis (AD) results from inflammation of a colonic diverticulum. It is the most common cause of acute left lower-quadrant pain in adults and represents a common reason for acute hospitalization, as it affects over half of the population over 65 years with a prevalence that increases with age. Although 85% of colonic diverticulitis will recover with a nonoperative treatment, some patients may have complications such as abscesses, fistulas, obstruction, and /or perforation at presentation. For these reasons, different classifications were introduced through times to help clinicians to develop a correct diagnosis and guide the treatment and for the same reasons imaging is used in most cases both to realise a differential diagnosis and to guide the therapeutic management...
July 15, 2013: Critical Ultrasound Journal
Jordi Ribera, Lurdes Zamora, Jordi Juncà, Inés Rodríguez, Silvia Marcé, Marta Cabezón, Fuensanta Millá
In up to 5-15% of studies of lymphoproliferative disorders (LPD) flow cytometry (FCM) or immunomorphologic methods cannot discriminate malignant from reactive processes. The aim of this work was to determine the usefulness of PCR for solving these diagnostic uncertainties. We analyzed IGH and TCRγ genes by PCR in 106 samples with inconclusive FCM results. A clonal result was registered in 36/106 studies, with a LPD being confirmed in 27 (75%) of these cases. Specifically, 9/9 IGH clonal and 16/25 TCRγ clonal results were finally diagnosed with LPD...
July 25, 2013: Cytometry. Part B, Clinical Cytometry
Lukas Kofler, Hanno Ulmer, Heinz Kofler
Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective...
2011: ISRN Allergy
Stefan Dumitrache-Rujinski, George Calcaianu, Dragos Zaharia, Alina Croitoru, Miron Alexandru Bogdan
SESSION TYPE: Sleep PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: The nocturnal pulse oximetry is used as a validated screening method in the diagnostic approach of Sleep Apnea Syndrome (SAS). The aim is to asses the role of nocturnal pulse oximetry as a screening method in subjects with morbid obesity (BMI>40 kg/m2) comparing with those with BMI<30kg/m2.METHODS: We evaluated 123 obese (BMI>40 kg/m2) patients (Group A) and 76 patients with BMI<30kg/m2 (Group B) with high pre-test clinical suspicion of SAS (Epworth sleepiness scale >10, snoring, witnessed apneas)...
October 1, 2012: Chest
Petre Vlah-Horea Botianu, Alexandru-Mihail Botianu
SESSION TYPE: Thoracic Surgery Posters IPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: The aim of this study is to evaluate the possibilities and limitations of using muscle flaps for postoperative empyema after major thoracic procedures.METHODS: Between 01.01.2003-01.01.2011 we used muscle flaps during major reoperations in 26 cases of postoperative empyema. The primary procedure was decortication - 14 cases (alone in 4 cases, associated with other procedures in 10 cases), pneumonectomy - 4 cases, lobectomy - 4 cases, non-anatomic resection - 5 cases and thoracoplasty - 1 case...
October 1, 2012: Chest
R Caetano, M Campos, F Lima
Cerebral oximetry non-invasive technology is based on cerebral tissue oxygen saturation (StcO2) measure in microcirculation, through near-infrared spectroscopy (NIRS)). As a result, cerebral oximetry (StcO2) is a mixed oxygen saturation parameter between de-oxide and oxide hemoglobin witch estimates a value between arterial (SaO2) and jugular venous saturation (SvjO2) under physiologic conditions. Complementary to the arterial oxygen saturation measured by pulse oximetry, cerebral tissue oxygen saturation reflects regional cerebral metabolism and the balance of local cerebral oxygen supply and demand...
July 2011: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Eduardo D Mussano, Laura B Onetti, Isaac I Cadile, Carlos M Onetti
INTRODUCTION: Preparations of intravenous immunoglobulin (IVIG) are used as treatment in different diseases such primary and secondary immunodeficiencies, autoimmune diseases, systemic inflammatory diseases, infectious diseases and allergic diseases among others. OBJECTIVE: to present 13 of our cases with the use of IVIG in different rheumatic diseases. PATIENTS AND METHODS: we retrospectively studied 13 patients (10 women and 3 men), mean age 29 years with different rheumatic diseases, that underwent conventional treatments without positive response...
2012: Revista de la Facultad de Ciencias Médicas
E Ernst
More than 400 plants with suspected glucose-lowering potential are known. In most cases, the evidence for this action is based purely on animal experiments or traditional use. This, however, provides only limited information about its clinical usefullness. Therefore this paper reviews direct evidence from clinical trials. A systematic literature search identified 22 such papers. The majority reported positive effects. However, much of the data are of poor methodological quality. Only five randomised controlled trials were found, and even these do not convincingly demonstrate the usefulness of the remedies in question...
March 1997: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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