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Clinical usefullness

Xiaoyu Xiao, Yingxian Zhu, Juyuan Bu, Guowei Li, Zibin Liang, Lukun Yang, Bingzong Hou
This study was designed to explore the effect of 3-methyladenine (3-MA) on sevoflurane anesthesia-induced cognitive dysfunction. A total of 60 C57BL/6 (5-8 months old) mice were randomly arranged into 3 groups: Control, sevoflurane (Sev) and Sev+3-MA group with 3-MA administration was performed during Sev administration. Morris water maze and Y-maze test were performed to examine the behavioral disorders. Moreover, hippocampal neuronal cell apoptosis and expression of autophagy related genes were detected. Sevoflurane induced cognitive dysfunction in mice showing significant longer escape latency, lower number of correct response, higher apoptotic neurons, and higher expression of autophagy related genes...
April 1, 2017: Die Pharmazie
Giuseppe Tavormina, Francesco Franza, Giuseppe Stranieri, Luigi Juli, Maria Rosaria Juli
The rating scale "G.T. MSRS" has been designed to improve the clinical effectiveness of the clinician psychiatrists, by enabling them to make an early "general" diagnosis of mixed states. The knowledge of the clinical features of the mixed states and of the symptoms of the "mixity" of mood disorders is crucial: to mis-diagnose or mis-treat patients with these symptoms may increase the suicide risk and make worse the evolution of mood disorders going to the dysphoric state. This study is the second validation study of the "G...
September 2017: Psychiatria Danubina
Antonio Celesti, Fazio Maria, Agata Romano, Alessia Bramanti, Placido Bramanti, Massimo Villari
The Open Archive Information System (OAIS) is a reference model for organizing people and resources in a system, and it is already adopted in care centers and medical systems to efficiently manage clinical data, medical personnel and patients. Archival storage systems are typically implemented using traditional relational database systems, but the relation-oriented technology strongly limits the efficiency in the management of huge amount of patients' clinical data, especially in emerging Cloud-based, that are distributed...
March 10, 2017: IEEE Journal of Biomedical and Health Informatics
X D Jiang, G Luo, X H Wang, L L Chen, X Ke, Y Li
Objective: To investigate Oct4 and Sox2 protein expression in tongue squamous cell carcinoma (TSCC) and the relationships between the expressions of Oct4 and Sox2 and clinical pathological characteristics and survival of patients. Methods: The paraffin imbedded tissue specimens of 51 patients with histologically confirmed TSCC were included. Immunohistochemistry was employed to detect the protein expression of Oct4 and Sox2 in 51 TSCC tissue samples. The protein expression levels of Oct4 and Sox2 and their relationships with both clinicopathological features and survival of patients with TSCC were evaluated...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Philippe Codron, Arnaud Chevrollier, Mariame S Kane, Andoni Echaniz-Laguna, Philippe Latour, Pascal Reynier, Dominique Bonneau, Christophe Verny, Vincent Procaccio, Guy Lenaers, Julien Cassereau
Charcot-Marie-Tooth type 2A disease (CMT2A) is an inherited peripheral neuropathy mainly caused by mutations in the MFN2 gene coding for the mitochondrial fusion protein mitofusin 2. Although the disease is mainly inherited in a dominant fashion, few cases of early-onset autosomal recessive CMT2A (AR-CMT2A) have been reported in recent years. In this study, we characterized the structure of the mitochondrial network in cultured primary fibroblasts obtained from AR-CMT2A family members. The patient-derived cells showed an increase of the mitochondrial fusion with large connected networks and an increase of the mitochondrial volume...
December 2016: Journal of the Peripheral Nervous System: JPNS
Dennis C Liotta, George R Painter
The HIV/AIDS epidemic, which was first reported on in 1981, progressed in just 10 years to a disease afflicting 10 million people worldwide including 1 million in the US. In 1987, AZT was approved for treating HIV/AIDS. Unfortunately, its clinical usefullness was severly limited by associated toxicities and the emergence of resistance. Three other drugs that were approved in the early 1990s suffered from similar liabilities. In 1990, the Liotta group at Emory University developed a highly diastereoselective synthesis of racemic 3'-thia-2',3'-dideoxycytidine and 3'-thia-2',3'-5-fluorodideoxycytidine and demonstrated that these compounds exhibited excellent anti-HIV activity with no apparent cytotoxicity...
2016: Accounts of Chemical Research
Annemie Prové, Luc Dirix
Neratinib is an orally available, pan-HER inhibitor with clinical activity in patients with HER2-amplified and HER2-mutated breast cancer. Areas Covered. A summary of publically available and relevant clinical data on neratinib. Expert Opinion. Neratinib (N) is clearly distinct from lapatinib (L), a difference based on its broad anti-HER effect, its covalent target binding and its toxicity profile. The main toxicity of neratinib is gastro-intestinal and is essentially limited to diarrhea. Although not directly compared with single agent lapatinib, skin toxicity is much less pronounced with N...
October 3, 2016: Expert Opinion on Pharmacotherapy
Erman Ceyhan, Onder Murat Delialioglu, Kenan Bayrakci, Bulent Daglar, Alper Deveci, Ugur Gunel
AIM: The aim of the study was to develop new equipment for the assessment of the flexibility of the spine with different forces. This new system should provide a different perspective to adolescent idiopathic scoliosis (AIS) for the selection of fusion levels and surgical success. MATERIAL AND METHODS: Eighteen patients suffering from AIS who were scheduled to undergo posterior instrumented spinal fusion in our clinic were recruited in this study. The Electronic Traction Table (ETT) that was designed in our clinic was used to evaluate the radiogical and clinical parameters of the spine...
2017: Turkish Neurosurgery
Fatma Tülin Kayhan, Selçuk Güneş, Arzu Karaman Koç, Ayşe Pelin Yiğider, Kamil Hakan Kaya
OBJECTIVES: Laryngoceles are air-filled sacs which communicate with the laryngeal lumen. When filled with mucus or pus, they are called laryngomucoceles and laryngopyoceles, respectively. Transoral robotic surgery (TORS) is a new and remarkable technique that expands its usefullness in otorhinolaryngology. Conventional treatments for laryngoceles were previously performed using external approaches, with aesthetically unfavorable and less function-sparing results. Transoral laser microsurgical approaches for laryngoceles were seldom reported...
June 2016: Journal of Craniofacial Surgery
Antoine Simon, Mohamed Nassef, Bastien Rigaud, Guillaume Cazoulat, Joël Castelli, Caroline Lafond, Oscar Acosta, Pascal Haigron, Renaud de Crevoisier
Adaptive radiation therapy (ART) is based on the optimization of the treatment plan during the treatment delivery to compensate for anatomical deformations. Deformable Image Registration (DIR) then constitutes a key step in order to analyze the huge amount of daily or weekly images to provide clinically usefull information. Two main applications of DIR have been developped in ART: delineation propagation and dose accumulation. If delineation propagation is well validated and transfered in the clinic, some challenges remain to address for dose accumulation...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Gregory R Lisciandro
OBJECTIVE: To evaluate the clinical usefulness of the diaphragmatico-hepatic (DH) view of the abdominal and thoracic focused assessment with sonography for triage (AFAST/TFAST) in detecting pericardial effusion (PE) in dogs. DESIGN: Retrospective case series from 2011 to 2012. SETTING: Private practice emergency and critical care hospital. ANIMALS: Twenty-four dogs with PE diagnosed by FAST. INTERVENTIONS: None...
January 2016: Journal of Veterinary Emergency and Critical Care
Giuseppe Tavormina
The knowledge of the clinical features of the mixed states and of the symptoms of the "mixity" of mood disorders is crucial: to mis-diagnose or mis-treat patients with these symptoms may increase the suicide risk and make worse the evolution of mood disorders. The rating scale "G.T. MSRS" has been designed to improve the clinical effectiveness of both psychiatrists and GPs by enabling them to make an early "general" diagnosis of mixed states. This study presents some cases in which the "G.T. MSRS" scale has been used, in order to demonstrate its usefullness...
September 2015: Psychiatria Danubina
Luca Mezzetto, Lorenzo Scorsone, Rosario Pacca, Giovanni Puppini, Simone Perandini, Gian Franco Veraldi
BACKGROUND: Autologous saphenous vein is considered the gold standard conduit in the femoral-popliteal revascularization for popliteal artery aneurysms (PAAs). In several cases, it may be absent or unsuitable for length or diameter and so it may be considered unfit for a conduit. In such patients, a synthetic graft or the endovascular correction can be useful, but results are controversial. In this retrospective case series, we have analyzed the safety and efficacy of the cryopreserved homograft (CHg) as a conduit in the PAA revascularization...
August 2015: Annals of Vascular Surgery
Gordana M Mumović
BACKGROUND/AIM: After external partial laryngectomias, videostroborscopy is very usefull in evaluation of postoperative phonatory mehanisms showing the "slow motion" of the vibrations of the remaining laryngeal structures. The aim of this paper was to compare the videostroboscopic characteristics of the vibration and to establish the differences in the phonation mechanisms depending on the type of external partial laryngectomy performed. METHODS: This prospective study was conducted during the period 2003-2009 at the Ear, Nose and Throat Clinic, Clinical Center of Vojvodina, Novi Sad, including 99 patients with laryngeal carcinoma, treated with open surgical approach using different types of vertical and horizontal partial laryngectomy...
January 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Anna Zubilewicz, Joanna Dolar-Szczasny, Ewa Rakowska, Jerzy Mackiewicz
PURPOSE: We describe a case of choroidal folds coexisting with ethmoidal myxoma and the evolution of folds after tumor excision. Choroidal folds can occure in the case of intraorbital pathology. Optical coherence tomography is usefull in diagnosis and monitoring of these folds. MATERIAL AND METHODS: 45 years old woman was reffered to our clinic because of visal disturbances in her right eye. Visual acuity of right eye was 0.5, of the left eye 1.0. Intraocular pressure of both eyes was within normal limits...
2013: Klinika Oczna
Erhan Tenekecioglu, Fahriye Vatansever Agca, Kemal Karaagac, Ozlem Arican Ozluk, Tezcan Peker, Mustafa Kuzeytemiz, Muhammed Senturk, Mustafa Yılmaz
Abstract The onset of AF results in a significant increase in mortality rates and morbidity in hypertensive patients and this rhythm disorder exposes patients to a significantly increased risk of cerebral or peripheral embolisms. Tissue Doppler imaging was found to be useful in early detection of myocardial dysfunction in several diseases. It was shown that tissue Doppler analysis of the walls of the left atrial appendage (LAA) can give accurate information about the function of the LAA in hypertensive patients...
2014: Clinical and Experimental Hypertension: CHE
Maria Antonietta Mazzei, Nevada Cioffi Squitieri, Susanna Guerrini, Amato Antonio Stabile Ianora, Lucio Cagini, Luca Macarini, Melchiore Giganti, Luca Volterrani
Acute diverticulitis (AD) results from inflammation of a colonic diverticulum. It is the most common cause of acute left lower-quadrant pain in adults and represents a common reason for acute hospitalization, as it affects over half of the population over 65 years with a prevalence that increases with age. Although 85% of colonic diverticulitis will recover with a nonoperative treatment, some patients may have complications such as abscesses, fistulas, obstruction, and /or perforation at presentation. For these reasons, different classifications were introduced through times to help clinicians to develop a correct diagnosis and guide the treatment and for the same reasons imaging is used in most cases both to realise a differential diagnosis and to guide the therapeutic management...
July 15, 2013: Critical Ultrasound Journal
Jordi Ribera, Lurdes Zamora, Jordi Juncà, Inés Rodríguez, Silvia Marcé, Marta Cabezón, Fuensanta Millá
In up to 5-15% of studies of lymphoproliferative disorders (LPD) flow cytometry (FCM) or immunomorphologic methods cannot discriminate malignant from reactive processes. The aim of this work was to determine the usefulness of PCR for solving these diagnostic uncertainties. We analyzed IGH and TCRγ genes by PCR in 106 samples with inconclusive FCM results. A clonal result was registered in 36/106 studies, with a LPD being confirmed in 27 (75%) of these cases. Specifically, 9/9 IGH clonal and 16/25 TCRγ clonal results were finally diagnosed with LPD...
July 25, 2013: Cytometry. Part B, Clinical Cytometry
Lukas Kofler, Hanno Ulmer, Heinz Kofler
Background. Histamine intolerance results from an imbalance between histamine intake and degradation. In healthy persons, dietary histamine can be sufficiently metabolized by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the key enzyme in degradation. Histamine elicits a wide range of effects. Histamine intolerance displays symptoms, such as rhinitis, headache, gastrointestinal symptoms, palpitations, urticaria and pruritus. Objective...
2011: ISRN Allergy
Stefan Dumitrache-Rujinski, George Calcaianu, Dragos Zaharia, Alina Croitoru, Miron Alexandru Bogdan
SESSION TYPE: Sleep PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: The nocturnal pulse oximetry is used as a validated screening method in the diagnostic approach of Sleep Apnea Syndrome (SAS). The aim is to asses the role of nocturnal pulse oximetry as a screening method in subjects with morbid obesity (BMI>40 kg/m2) comparing with those with BMI<30kg/m2.METHODS: We evaluated 123 obese (BMI>40 kg/m2) patients (Group A) and 76 patients with BMI<30kg/m2 (Group B) with high pre-test clinical suspicion of SAS (Epworth sleepiness scale >10, snoring, witnessed apneas)...
October 1, 2012: Chest
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