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Hark-Soo Park, Seon-Ju Kim, Taek-Jin Lee, Geon-Yong Kim, EunHo Meang, Jeong-Sup Hong, Su-Hyon Kim, Sang-Bum Koh, Seung-Guk Hong, Yle-Shik Sun, Jin Seok Kang, Yu-Ri Kim, Meyoung-Kon Kim, Jayoung Jeong, Jong-Kwon Lee, Woo-Chan Son, Jae-Hak Park
PURPOSE: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnO(SM20(+))) nanoparticles in Sprague Dawley rats for 90 days. METHODS: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg) and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects...
2014: International Journal of Nanomedicine
Hark-Soo Park, Sung-Sup Shin, Eun Ho Meang, Jeong-sup Hong, Jong-Il Park, Su-Hyon Kim, Sang-Bum Koh, Seung-Young Lee, Dong-Hyouk Jang, Jong-Yun Lee, Yle-Shik Sun, Jin Seok Kang, Yu-Ri Kim, Meyoung-Kon Kim, Jayoung Jeong, Jong-Kwon Lee, Woo-Chan Son, Jae-Hak Park
PURPOSE: The widespread use of nanoparticles (NPs) in industrial and biomedical applications has prompted growing concern regarding their potential toxicity and impact on human health. This study therefore investigated the subchronic, systemic oral toxicity and no-observed-adverse-effect level (NOAEL) of 20 nm, negatively charged zinc oxide (ZnO(SM20(-))) NPs in Sprague Dawley rats for 90 days. METHODS: The high-dose NP level was set at 500 mg/kg of bodyweight, and the mid- and low-dose levels were set at 250 and 125 mg/kg, respectively...
2014: International Journal of Nanomedicine
Eun Jung Park, Se Jin Lee, Do Yle Koh, Yoo Mi Han
Transcranial magnetic stimulation (TMS) is a noninvasive and safe technique for motor cortex stimulation. TMS is used to treat neurological and psychiatric disorders, including mood and movement disorders. TMS can also treat several types of chronic neuropathic pain. The pain relief mechanism of cortical stimulation is caused by modifications in neuronal excitability. Depression is a common co-morbidity with chronic pain. Pain and depression should be treated concurrently to achieve a positive outcome. Insomnia also frequently occurs with chronic lower back pain...
July 2014: Korean Journal of Pain
Eun Jung Park, Sun Young Park, Se Jin Lee, Nan Seol Kim, Do Yle Koh
Cervical disc herniation is a common disorder characterized by neck pain radiating to the arm and fingers as determined by the affected dermatome. This condition has a favorable prognosis, but pain can have a serious detrimental impact on daily activities. Epidural neuroplasty has been applied as a treatment option for cervical disc herniation; however, no study has addressed the clinical outcomes. This retrospective study evaluated the clinical outcomes of epidural neuroplasty on 128 patients for the treatment of cervical disc herniation...
March 2013: Journal of Korean Medical Science
Seon-Yle Ko
OBJECTIVE: Periodontitis is an inflammatory disease that affects connective tissue attachments and the supporting bone that surrounds the teeth. Gingival fibroblasts induce the overexpression of matrix metalloproteinase (MMP), which is involved in inflammatory progression in periodontitis. Osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. This study examined the anti-destructive effects of myricetin on human gingival fibroblasts (HGF) under lipopolysaccharide- (LPS-) induced inflammatory conditions, and the anti-osteoclastogenetic effect of myricetin on the receptor activator of NF-κB ligand (RANKL) induced RAW264...
December 2012: Archives of Oral Biology
Young-Joo Jang, Mee-Eun Kim, Seon-Yle Ko
OBJECTIVE: Periodontitis is a group of inflammatory diseases that affect connective tissue attachments and the supporting bone that surround the teeth. Osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. This study examined the anti-inflammatory effects of Panax notoginseng (PN) on periodontal ligament fibroblasts (PDLFs) and RAW264.7 cells under lipopolysaccharide (LPS) induced inflammatory conditions...
November 2011: Archives of Oral Biology
Rongrong Zhang, James R Edwards, Seon-Yle Ko, Shanshan Dong, Hongbin Liu, Babatunde O Oyajobi, Christopher Papasian, Hong-Wen Deng, Ming Zhao
Intermittent application of parathyroid hormone (PTH) has well established anabolic effects on bone mass in rodents and humans. Although transcriptional mechanisms responsible for these effects are not fully understood, it is recognized that transcriptional factor cAMP response element binding protein (CREB) mediates PTH signaling in osteoblasts, and that there is a communication between the PTH-CREB pathway and the BMP2 signaling pathway, which is important for osteoblast differentiation and bone formations...
2011: PloS One
Hongbin Liu, Rongrong Zhang, Seon-Yle Ko, Babatunde O Oyajobi, Christopher J Papasian, Hong-Wen Deng, Shujun Zhang, Ming Zhao
Cytoskeleton microtubules regulate various cell signaling pathways that are involved in bone cell function. We recently reported that inhibition of microtubule assembly by microtubule-targeting drugs stimulates osteoblast differentiation and bone formation. To further elucidate the role of microtubules in bone homeostasis, we characterized the skeletal phenotype of mice null for stathmin, an endogenous protein that inhibits microtubule assembly. In vivo micro-computed tomography (µCT) and histology revealed that stathmin deficiency results in a significant reduction of bone mass in adult mice concurrent with decreased osteoblast and increased osteoclast numbers in bone tissues...
September 2011: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jin-Hee Min, Seon-Yle Ko, Yong-Bum Cho, Chun-Jeih Ryu, Young-Joo Jang
Despite the frequent use of primary dental pulp cells in dental regenerative research, few systematic studies of stemness for osteogenic and dentinogenic differentiation of human adult pulp cells have been reported. To investigate the stemness of human adult dental pulp cells, pulp tissues were obtained from extracted third molars and used as a source of pulp cells. In FACS analysis and immunophenotyping, the general mesenchymal stem cell markers CD44, CD90, and CD146 were highly expressed in early passages of the pulp cell culture...
March 2011: Human Cell
M Jamshidi, M Ghaedi, K Mortazavi, M Nejati Biareh, M Soylak
Selective, sensitive and efficient methods for preconcentration of trace amounts of metal ions including Cr(3+), Cu(2+), Zn(2+) and Ni(2+) ions by incorporation of 2-hydroxy-(3-((1-H-indol 3-yle)phenyl) methyl) 1-H-indol (2-HIYPMI) on SDS-A has been reported. The proposed methods are based on the uptake of chelate of under study metal ions with these new ligands loaded on SDS-A. The influences of the analytical parameters including pH, ligand and SDS amount, eluting solution (type and concentrations) and sample volume on metal ions recoveries were investigated...
June 2011: Food and Chemical Toxicology
Meng-Ching Chen, Ching-Han Yu, Shyi-Wu Wang, Hsiao-Fung Pu, Shu-Fen Kan, Lie-Chwen Lin, Chin-Wen Chi, Lary Low-Tone Ho, Chen-Hsen Lee, Paulus S Wang
The incidence of thyroid cancer increases with age, and it is twice in women as common as in men. The undifferentiated thyroid cancer (UTC) is the most aggressive of all thyroid cancers. Unfortunately, there are almost no efficacious therapeutic modalities. It is important to develop some new effective therapies. Evodiamine is a chemical extracted from a kind of Chinese herb named Wu-Chu-Yu and has been demonstrated to be effective in preventing the growth of a variety of cancer cells. In the present study, the mechanism by which evodiamine inhibited the undifferentiated thyroid cancer cell line ARO was examined...
August 15, 2010: Journal of Cellular Biochemistry
J M Auerbach, R L Schmitt
We describe a monolithic diode-laser-pumped Nd:YLF minilaser that operates at 1.053 microm. By aligning the c axis of the Nd:YLF crystal parallel to the laser resonator axis we are able to suppress completely lasing on the (higher-gain) 1.047-microAtmra nsition of Nd:YLE We describe the design and fabrication of the laser and report its cw and gain-switched performance. Our measurements of the laser performance agree well with calculations.
August 1, 1991: Optics Letters
Ming Zhao, Seon-Yle Ko, Jin-Hua Liu, Di Chen, Jianghong Zhang, Baolin Wang, Stephen E Harris, Babatunde O Oyajobi, Gregory R Mundy
Bone morphogenetic protein 2 (BMP-2) is essential for postnatal bone formation and fracture repair. By screening chemical libraries for BMP-2 mimics using a cell-based assay, we identified inhibitors of microtubule assembly as stimulators of BMP-2 transcription. These microtubule inhibitors increased osteoblast differentiation in vitro, stimulated periosteal bone formation when injected locally over murine calvaria, and enhanced trabecular bone formation when administered systemically in vivo. To explore molecular mechanisms mediating these responses, we examined effects of microtubule inhibitors on the hedgehog (Hh) pathway, since this pathway is known to regulate BMP-2 transcription in osteoblasts and microtubules have been shown to be involved in Hh signaling in Drosophila...
March 2009: Molecular and Cellular Biology
Ching-Han Yu, Shu-Fen Kan, Hsiao-Fung Pu, Eileen Jea Chien, Paulus S Wang
Prostate cancer has its highest incidence in the USA and is becoming a major concern in Asian countries. Bufadienolides are extracts of toxic glands from toads and are used as anticancer agents, mainly on leukemia cells. In the present study, the antiproliferative and apoptotic mechanisms of bufalin and cinobufagin on prostate cancer cells were investigated. Proliferation of LNCaP, DU145, and PC3 cells was measured by 3-(4,5-dimethylthiazol-2-yle)-2,5-diphenyltetrazolium bromide assay and the doubling time (tD) was calculated...
December 2008: Cancer Science
Sun-Hwa Chang, Youngnim Choi, Jung-Ae Park, Dong-Sik Jung, Jieun Shin, Ji-Hyun Yang, Seon-Yle Ko, Se-Won Kim, Jung-Keun Kim
BACKGROUND & AIMS: Although there has been some success with protein-based anti-tumor necrosis factor alpha (TNF-alpha) therapeutics, the problems associated with protein-based drugs demand alternative approaches. We screened various herbal extracts for their ability to inhibit TNF-alpha secretions and found that BT-201, an n-butanol extract of Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) has such an ability. METHODS: The purpose of this study has been to evaluate the anti-inflammatory and anti-rheumatic effects of BT-201...
December 2007: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Young-Joo Jang, Jae-Hoon Ji, Young-Chul Choi, Chun Jeih Ryu, Seon-Yle Ko
DNA damage triggers multiple checkpoint pathways to arrest cell cycle progression. Polo-like kinase 1 (Plk1) is an important regulator of several events during mitosis. In addition to Plk1 functions in cell cycle, Plk1 is involved in DNA damage check-point in G2 phase. Normally, ataxia telangiectasia-mutated kinase (ATM) is a key enzyme involved in G2 phase cell cycle arrest following DNA damage, and inhibition of Plk1 by DNA damage during G2 occurs in a ATM/ATR-dependent manner. However, it is still unclear how Plk1 is regulated in response to DNA damage in mitosis in which Plk1 is already activated...
January 26, 2007: Journal of Biological Chemistry
Se-Won Kim, Hyung-Gun Kim, Byung-Eui Lee, Hyeon-Hwan Hwang, Dong-Heon Baek, Seon-Yle Ko
We performed the present study to investigate whether Pleurotus eryngii extracts (PEX) play a role in bone metabolism. PEX treatment showed increase in the alkaline phosphatase activity of the osteoblasts and in the osteocalcin mRNA expression from primary osteoblasts. PEX also increased the expression of the Runx2 gene, and the secretion of osteoprotegerin from the osteoblasts showed marked increases after treatment with PEX. In addition, PEX treatment decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and resorption areas...
February 2006: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Sun-Hwa Chang, Ha-Chang Sung, Youngnim Choi, Seon-Yle Ko, Byung-Eui Lee, Dong-Heon Baek, Se-Won Kim, Jung-Keun Kim
AIF has been formulated using three herbs known to have anti-inflammatory and anti-osteolytic effects. In this study, the potential therapeutic effects of AIF for rheumatoid arthritis were assessed in vitro and in vivo. The effects of AIF on the inflammation (TNF-alpha, IL-1, iNO), cartilage protection (MMP-13), and selective killing of activated T cells were examined, in vitro. In addition, the therapeutic effect of AIF was evaluated using a collagen-induced arthritis (CIA) mouse model. DBA/1 mice were immunized with type II collagen...
August 2005: International Immunopharmacology
J Ahlberg, A Savolainen, M Rantala, H Lindholm, M Könönen
OBJECTIVES AND METHODS: In this follow-up study of 30-50-year-old employees (n = 211) of the Finnish Broadcasting Company (YLE), respondents completed questionnaires in both 1999 and 2000 containing items on demographic data, tobacco use, levels of perceived bruxism, affective disturbance, sleep disturbance, somatic symptoms, pain symptoms and temporomandibular disorder (TMD) symptoms. RESULTS: Bruxism was significantly more prevalent among smokers (P = 0.005). Age, marital status, and gender were not associated with bruxism...
August 2004: Community Dentistry and Oral Epidemiology
Shu-Fen Kan, William J Huang, Lie-Chwen Lin, Paulus S Wang
Evodiamine, isolated from a Chinese herbal drug named Wu-Chu-Yu, possesses many biological functions. Recently, it has been reported that Wu-Chu-Yu exerts an antiproliferative effect on several cancers. Prostate carcinoma initially occurs as an androgen-dependent tumor and is the second leading cause of cancer death in American males. In the present study, the effect of evodiamine on the growth of androgen-dependent prostate cancer cell line LNCaP in vitro was examined. Based on [3-(4,5-dimethylthiazol-2-yle)2,5-diphenyltetrazolium bromide] (MTT) assay, evodiamine significantly inhibited the growth of LNCaP cells in a concentration-dependent manner...
July 10, 2004: International Journal of Cancer. Journal International du Cancer
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