Anna C F Lewis, Rex L Chisholm, John J Connolly, Edward D Esplin, Joe Glessner, Adam Gordon, Robert C Green, Hakon Hakonarson, Margaret Harr, Ingrid A Holm, Gail P Jarvik, Beth Karlson, Eimear E Kenny, Leah Kottyan, Niall Lennon, Jodell E Linder, Yuan Luo, Lisa J Martin, Emma Perez, Megan J Puckelwartz, Laura J Rasmussen-Torvik, Maya Sabatello, Richard R Sharp, Jordan W Smoller, Rene Sterling, Shannon Terek, Wei-Qi Wei, Stephanie M Fullerton
The differential performance of polygenic risk scores (PRSs) by group is one of the major ethical barriers to their clinical use. It is also one of the main practical challenges for any implementation effort. The social repercussions of how people are grouped in PRS research must be considered in communications with research participants, including return of results. Here, we outline the decisions faced and choices made by a large multi-site clinical implementation study returning PRSs to diverse participants in handling this issue of differential performance...
April 18, 2024: American Journal of Human Genetics