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https://www.readbyqxmd.com/read/29768912/association-between-urinary-sodium-levels-and-iodine-status-in-korea
#1
Jonghwa Ahn, Jang Ho Lee, Jiwoo Lee, Ji Yeon Baek, Eyun Song, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National Health and Nutrition Examination Survey (VI 2-3, 2014 to 2015). We included 3,645 subjects aged 10 to 75 years with normal kidney function and without a history of thyroid disease. Adequate iodine intake was defined as a urinary iodine/creatinine (I/Cr) ratio of 85 to 220 µg/g...
May 18, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29768278/lower-plasma-klotho-concentrations-are-associated-with-vascular-dementia-but-not-late-onset-alzheimer-s-disease
#2
Gloria Brombo, Francesco Bonetti, Beatrice Ortolani, Mario Luca Morieri, Cristina Bosi, Angelina Passaro, Giovanni B Vigna, Caterina Borgna, Maria Vittoria Arcidicono, Veronica Tisato, Giovanni Zuliani
BACKGROUND: The protein Klotho is involved in biological processes related to longevity, cardiovascular health, and cognition. Serum Klotho levels have been associated with better cognition in animal models; moreover, lower Klotho concentrations in cerebrospinal fluid from subjects with late-onset Alzheimer's disease (LOAD) have been reported. OBJECTIVE: Our study aimed to examine the possible relationship between Klotho plasma concentrations and cognitive status in the elderly...
May 16, 2018: Gerontology
https://www.readbyqxmd.com/read/29761371/tolerability-and-efficacy-of-deferasirox-in-patients-with-transfusional-iron-overload-results-from-a-german-2-year-non-interventional-study
#3
Florian Nolte, Holger Nückel, Burkhard Schmidt, Thomas Geer, Oleg Rubanov, Holger Hebart, Andrea Jarisch, Stefan Albrecht, Christiane Johr, Christiane Schumann, Wolf-Karsten Hofmann
BACKGROUND: Iron overload (IOL) due to repetitive transfusions of packed red blood cells (pRBC) has a major impact on morbidity and mortality in patients with inherited bone marrow failure syndromes and hemoglobinopathies such as thalassemia and sickle cell disease. However, whether IOL influences the outcome of elderly patients with myeloid malignancies is not yet clear. Moreover, clinical trials have reported high drop-out rates during treatment with the oral iron chelator deferasirox (DFX)...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29756493/association-between-urinary-sodium-excretion-and-coronary-heart-disease-in-hospitalized-elderly-patients-in-china
#4
Chun-Lin Li, Hai-Jun Wang, Quan-Jin Si, Jin Zhou, Kai-Liang Li, Yu Ding
Objective This study was performed to evaluate the association between urinary sodium excretion and coronary heart disease (CHD) in hospitalized elderly patients in China. Methods The 24-h urinary excretion specimens of 541 patients were collected, and the serum creatinine concentration and urinary sodium/potassium ratio were measured. Associations were explored by multivariate logistic regression analysis. Results The mean 24-h urinary sodium excretion was 200.4 mmol, corresponding to 11.7 g of salt intake...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29738576/distinct-characteristics-and-outcomes-in-elderly-onset-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-with-nephritis-nationwide-cohort-study-of-data-from-the-japan-renal-biopsy-registry-j-rbr
#5
Hiroyuki Komatsu, Shouichi Fujimoto, Shoichi Maruyama, Masashi Mukoyama, Hitoshi Sugiyama, Kazuhiko Tsuruya, Hiroshi Sato, Jun Soma, Junko Yano, Seiji Itano, Tomoya Nishino, Toshinobu Sato, Ichiei Narita, Hitoshi Yokoyama
BACKGROUND: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR). METHODS: This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29736630/variations-in-clinical-management-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation-according-to-different-equations-for-estimating-renal-function-post-hoc-analysis-of-a-prospective-cohort
#6
Vincenzo Livio Malavasi, Daniele Pettorelli, Elisa Fantecchi, Cristina Zoccali, Giuliana Laronga, Tommaso Trenti, Gregory Yoke Hong Lip, Giuseppe Boriani
Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft-Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a post hoc analysis of a prospective cohort of patients with atrial fibrillation, we considered different equations: (1) CG for creatinine clearance (CrCl), (2) modification of diet in renal disease (MDRD), (3) CKD-EPI, (4) Berlin Initiative Study 1 (BIS-1) and (5) full age spectrum (FAS), for glomerular filtration rate (GFR)...
May 7, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29725634/bowman-capsule-volume-and-related-factors-in-adults-with-normal-renal-function
#7
Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo
Introduction: Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman capsule volume in normal human kidneys. Methods: We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman capsules and glomerular capillaries were used to estimate the mean Bowman capsule volume (BV) and glomerular capillary volume (GV) in each subject...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#8
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29665445/acute-kidney-injury-during-treatment-with-high-dose-cloxacillin-a-report-of-23-cases-and-literature-review
#9
Aurélie Lavergne, Cécile Vigneau, Elisabeth Polard, Louise Triquet, Nathalie Rioux-Leclercq, Pierre Tattevin, Léonard Golbin
BACKGROUND: International guidelines recommend high-dose cloxacillin for endocarditis or osteoarticular infections due to meticillin-susceptible staphylococci. However, data on the tolerability of these regimens are scarce. METHODS: We used the computerized registry of suspected drug-related adverse events in our institution. Cases of acute kidney injury (AKI), as defined by KDIGO, in patients receiving high-dose cloxacillin, were retrospectively reviewed. Data were collected from medical charts on a standardized questionnaire...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29664579/chronic-intra-oral-pain-and-depressive-symptoms-in-japanese-community-dwelling-elderly-a-longitudinal-study
#10
L Hanindriyo, A Yoshihara, T Takiguchi, H Miyazaki
OBJECTIVE: The incidence of major depressive disorder in the elderly ranges from 0.2 to 14.1/100 person-years, and the incidence of clinically relevant depressive symptoms is 6.8/100 person-years. This study aimed to assess the longitudinal relationship between chronic intra oral pain and depressive symptom in Japanese elderly. BASIC RESEARCH DESIGN: 3-year cohort study. PARTICIPANTS: 212 community-dwelling seniors (129 men, 83 women) aged 77 years residing in the city of Niigata, Japan in 2005...
April 17, 2018: Community Dental Health
https://www.readbyqxmd.com/read/29657212/mortality-in-the-elderly-with-acute-kidney-injury-in-an-internal-medicine-department-in-abidjan-cote-d-ivoire
#11
Hubert Kouamé Yao, Allah Yves Omer Binan, Serge-Didier Konan, Koffi Justin N'Da, Sery Patrick Diopoh
Acute kidney injury (AKI) in the elderly is characterized by high mortality. The objective of this study is to identify the causes of death in the elderly with AKI. This is a prospective cohort study with a descriptive purpose which was carried out during the period from January 2009 to December 2014 in the Department of Nephrology-Internal Medicine of Treichville University Hospital. The diagnosis of AKI was made on the basis of serum creatinine (SCr) values determined during hospitalization, according to KDIGO classification...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29652115/analysis-on-influencing-factors-of-abnormal-renal-function-in-elderly-patients-with-type-2-diabetes-mellitus
#12
Tao Chai, Dawei Zhang, Zhongxin Li
BACKGROUND: To investigate the related influencing factors of abnormal renal function in elderly in patients with type 2 diabetes mellitus (T2DM) and their clinical significance. METHODS: The clinical data of elderly T2DM patients hospitalized in Beijing Luhe Hospital from January 2013 to June2016 were retrospectively analyzed. According to their glomerular filtration rate (GFR) levels, these patients were divided into GFR ≥90 mL/min/1.73m2 group (Group A), GFR =60-90 mL/min/1...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29650358/prognostic-relevance-of-glomerular-filtration-rate-estimation-obtained-through-different-equations-in-hospitalized-elderly-patients
#13
Paolo Gallo, Antonio De Vincentis, Claudio Pedone, Alessandro Nobili, Mauro Tettamanti, Umberto Vespasiani Gentilucci, Antonio Picardi, Pier Mannuccio Mannucci, Raffaele Antonelli Incalzi
The estimated glomerular filtration rate (eGFR) is a predictor of important outcomes and its reduction has been associated with the risk of all-cause mortality in both general population and elderly patients. However while reduced renal function is common in older people, the best method for estimating GFR remains unclear, especially in an acute care setting. Most studies analyzing the accuracy of eGFR in the elderly were carried out in different heterogeneous settings. In this study, we compare the prognostic value of different formulas estimating GFR in predicting the risk of in-hospital morbidity and mortality within 3 months from discharge in elderly hospitalized patients...
April 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29644067/a-scheme-based-on-icd-10-diagnoses-and-drug-prescriptions-to-stage-chronic-kidney-disease-severity-in-healthcare-administrative-records
#14
Leif Friberg, Alessandro Gasparini, Juan Jesus Carrero
Background: Information about renal function is important for drug safety studies using administrative health databases. However, serum creatinine values are seldom available in these registries. Our aim was to develop and test a simple scheme for stratification of renal function without access to laboratory test results. Methods: Our scheme uses registry data about diagnoses, contacts, dialysis and drug use. We validated the scheme in the Stockholm CREAtinine Measurements (SCREAM) project using information on approximately 1...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29628565/postoperative-cognitive-dysfunction-in-indian-patients-undergoing-total-knee-replacement-under-spinal-anesthesia
#15
Praful Kilaru, A Ramachandra Reddy, Maryada Venketeshwar Reddy, Brijesh Kidiyoor, Vinay Mathew Joseph, Annapareddy Venkata Gurava Reddy
Introduction: Total knee replacement is a common surgical procedure in the elderly. The number of surgeries has increased owing to the increasing life expectancy of the population and better functional outcomes postsurgery. Postoperative cognitive dysfunction (POCD) is an identified entity postsurgery in elderly but most of the studies have been on patients undergoing cardiac and other nonorthopaedic surgeries. The studies have shown variable incidence due to selection bias. We studied the incidence and probable predictive factors of POCD in elderly Indian population undergoing total knee replacement under spinal anesthesia...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29623673/the-relationship-between-age-and-chronic-kidney-disease-in-patients-undergoing-pancreatic-resection
#16
Derrick Antoniak, Chandrakanth Are, Chad Vokoun, Kaeli Samson, Lynette Smith, Jason Shiffermiller
BACKGROUND: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65. METHODS: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery...
April 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29611105/quality-of-direct-oral-anticoagulant-prescribing-in-elderly-patients-with-non-valvular-atrial-fibrillation-results-from-a-large-urban-health-system
#17
Shakira J Grant, Shawn Kothari, Phyllis A Gimotty, Nalaka S Gooneratne, Adam Cuker
Non-valvular atrial fibrillation (NVAF) is common in older adults. Oral anticoagulation is indicated to reduce the risk of stroke and systemic embolism, but it also poses a risk of bleeding, particularly in the elderly. Direct oral anticoagulants (DOACs) provide an alternative to warfarin and their use in the treatment of AF is growing. We conducted a retrospective cohort study to assess the quality of DOAC prescribing in elderly patients with NVAF in a large academic health system and to compare practice with consensus best practice recommendations...
April 2, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29607531/vancomycin-induced-acute-kidney-injury-in-elderly-chinese-patients-a-single-center-cross-sectional-study
#18
Kun-Ming Pan, Yi Wu, Can Chen, Zhang-Zhang Chen, Jian-An Xu, Lei Cao, Qing Xu, Wei Wu, Pei-Fang Dai, Xiao-Yu Li, Qian-Zhou Lv
AIMS: Objective was to investigate current situation and risk factors of vancomycin (VAN)-induced acute kidney injury (VI-AKI) in elderly Chinese patients, to assess the outcomes and its risk factors of patients who developed VI-AKI, in order to provide suggestions for improving the prevention and treatment of VI-AKI in elderly Chinese patients. METHOD: We retrospectively identified elderly inpatients that received 4 or more doses of VAN treatment. We compared the VI-AKI with NO-AKI patients...
April 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29602632/urinary-biomarkers-of-kidney-tubular-damage-and-risk-of-cardiovascular-disease-and-mortality-in-elders
#19
Vasantha Jotwani, Ronit Katz, Joachim H Ix, Orlando M Gutiérrez, Michael Bennett, Chirag R Parikh, Steven R Cummings, Mark J Sarnak, Michael G Shlipak
RATIONALE & OBJECTIVE: Novel urinary biomarkers have enabled earlier detection of kidney tubular damage, but their prognostic value for adverse cardiovascular outcomes is uncertain. We hypothesized that tubular damage, measured by urine α1 -microglobulin (A1M), amino-terminal propeptide of type III procollagen (PIIINP), and neutrophil gelatinase-associated lipocalin (NGAL), would be associated with higher risks for cardiovascular events and mortality among elders. STUDY DESIGN: Case-cohort study...
March 27, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29590199/the-urine-albumin-creatinine-ratio-is-a-predictor-for-incident-long-term-care-in-a-general-population
#20
Shuko Takahashi, Fumitaka Tanaka, Yuki Yonekura, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Akira Okayama, Motoyuki Nakamura
BACKGROUND: Several types of cardiovascular diseases (CVDs) impair the physical and mental status. The purpose of this study was to assess the predictive ability of several cardiovascular biomarkers for identifying the incidence of disability as future recipients of public long-term care (LTC) service. METHODS: The subjects of this study were community-dwelling elderly individuals ≥ 65 years of age without a history of CVD (n = 5,755; mean age, 71 years). The endpoint of this study was official certification as a recipient of LTC...
2018: PloS One
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