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https://www.readbyqxmd.com/read/28746194/18f-fdg-pet-ct-is-an-ideal-imaging-modality-for-the-early-diagnosis-of-relapsing-polychondritis-a-case-report
#1
JianJie Wang, XiaoFei Liu, Chaoyu Pu, Yan Chen
BACKGROUND: Relapsing polychondritis (RP) is a rare autoimmune disease of unknown etiology that may affect multiple cartilage throughout the body. CASE REPORT: We report on a middle-aged man presented with cough, chest tightness, and fever of unknown origin, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) was performed. And the imaging shows multiple increased FDG accumulation in tracheobronchial tree and all intercostal cartilages, as well as in nasal, right auricule, laryngeal cartilage...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28743361/relapsing-polychondritis-prevalence-of-cardiovascular-diseases-and-its-risk-factors-and-general-disease-features-according-to-gender
#2
Pablo Arturo Olivo Pallo, Maurício Levy-Neto, Rosa Maria Rodrigues Pereira, Samuel Katsuyuki Shinjo
The comorbidities in relapsing polychondritis have been scarcely described in the literature. Moreover, apart from a few relapsing polychondritis epidemiological studies, no studies specifically addressing relapsing polychondritis distribution according to gender are available. Therefore, the objectives of the present study were: (a) to analyze the prevalence of cardiovascular diseases and its risk factors in a series of patients with relapsing polychondritis; (b) to determine the influence of gender on relapsing polychondritis...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28739564/silent-tracheobronchial-chondritis-in-a-patient-with-a-delayed-diagnosis-of-relapsing-polychondritis
#3
Faraz Afridi, Seema Frosh
Relapsing polychondritis is a very rare autoimmune disease characterised by a relapsing inflammation of hyaline, elastic and fibrous cartilaginous tissues. The incidence is estimated to be between 3.5 and 4.5 per million people per year. Clinical signs and symptoms can be very subtle, and if left undiagnosed for a prolonged period, airway involvement can cause fibrosis of the tracheobronchial wall, leading to a fixed tracheobronchial stenosis. Eventually, this can progress to life-threatening tracheobronchomalacia due to irreversible damage and loss of tissue integrity...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28720307/diagnosis-of-relapsing-polychondritis-in-a-patient-with-chronic-cough-and-without-nasal-or-auricular-chondritis
#4
Luis Gorospe Sarasúa, Deisy Barrios-Barreto, Ismael Said-Criado, Carlos de la Puente-Bujidos
No abstract text is available yet for this article.
July 15, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28710538/-manifestations-of-autoimmune-disorders-in-otorhinolaryngology-classical-symptoms-and-diagnostic-approach
#5
B Hofauer, A Chaker, K Thürmel, A Knopf
Manifestations of autoimmune disorders represent a diagnostic challenge. Many autoimmune disorders show typical manifestations in the ear, nose and throat and should be taken into account in the differential diagnosis. Sjogren's syndrome, various vasculitides and sarcoidosis represent the most common autoimmune disorders in otorhinolaryngology, but IgG4-related diseases, relapsing polychondritis and autoimmune disorders of the mucosa are also observed. Autoimmune diseases can lead to sensorineural deficits...
August 2017: HNO
https://www.readbyqxmd.com/read/28705782/biologics-in-myelodysplastic-syndrome-related-systemic-inflammatory-and-autoimmune-diseases-french-multicenter-retrospective-study-of-29-patients
#6
REVIEW
Arsene Mekinian, Guillaume Dervin, Nathanael Lapidus, Jean-Emmanuel Kahn, Louis Terriou, Eric Liozon, Eric Grignano, Jean-Charles Piette, Odile Beyne Rauzy, Vincent Grobost, Pascal Godmer, Jerome Gillard, Julien Rossignol, David Launay, Achille Aouba, Thierry Cardon, Laurence Bouillet, Jonathan Broner, Julien Vinit, Lionel Ades, Fabrice Carrat, Clementine Salvado, Eric Toussirot, Mathilde Versini, Nathalie Costedoat-Chalumeau, Jean Baptiste Fraison, Philippe Guilpain, Pierre Fenaux, Olivier Fain
BACKGROUND: Systemic inflammatory and autoimmune diseases (SIADs) associated with myelodysplastic syndromes are often difficult to treat. Corticosteroids are efficient but only usually at high doses. The use of biologics needs to be specified. METHODS: In a French multicenter retrospective study, we analyzed the efficacy and safety of biologics (tumor necrosis factor-α [TNF-α] antagonists, tocilizumab, rituximab and anakinra) for SIADs associated with myelodysplastic syndromes (MDSs)...
July 10, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28686532/management-of-hydrocephalus-associated-with-autoimmune-diseases-a-series-of-19-cases
#7
Baitao Ma, Hao Wu, Hexiang Yin, Jianbo Chang, Li Wang, Renzhi Wang, Wenbin Ma, Yongning Li, Jian Guan, Jinjing Liu, Junji Wei
OBJECTIVES: To analyze the diagnosis and treatment of hydrocephalus associated with autoimmune diseases and to explore the possible mechanism of hydrocephalus in these patients. METHODS: A retrospective case series study was conducted at Peking Union Medical College Hospital, Beijing, China. Files were retrieved from the hospital archives by screening records from Jan 1990 to Jan 2016. Medical records were screened for data regarding (1) the number of patients diagnosed with hydrocephalus associated with autoimmune diseases, (2) the clinical manifestation of hydrocephalus associated with autoimmune disease, and (3) the outcomes of these patients treated with medication or ventriculoperitoneal shunt (VPS)...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28668816/pet-ct-imaging-in-fever-of-unknown-origin-a-case-of-relapsing-polychondritis
#8
Hong-Lei Liu, Cheng-DE Yang
No abstract text is available yet for this article.
July 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28619741/saddle-nose-and-bilateral-cauliflower-ear-deformities-with-pyoderma-gangrenosum-like-ulcers-cavitary-pulmonary-lesions-digital-gangrene-and-pulselessness-in-a-young-female
#9
Sweta Subhadarshani, Vishal Gupta, Anurag Chahal, Kaushal K Verma
We report a young female who presented with saddle-nose and bilateral cauliflower ear deformities along with pyoderma gangrenosum-like ulcers, digital gangrene and pulselessness. Subsequently, she was found to have bilateral conductive hearing loss, a corneal opacity, mild aortic regurgitation and radiological evidence of cavitary changes in lungs and aortoarteritis. Our patient had a constellation of symptoms which posed a diagnostic challenge. Finally, a diagnosis of relapsing polychondritis with several unusual features was made...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28583280/clinical-value-of-fdg-pet-ct-for-the-evaluation-of-rheumatic-diseases-rheumatoid-arthritis-polymyalgia-rheumatica-and-relapsing-polychondritis
#10
REVIEW
Kazuo Kubota, Hiroyuki Yamashita, Akio Mimori
FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28552866/meningeal-plasma-cell-granuloma-in-the-early-stage-of-relapsing-polychondritis
#11
Shintaro Hayashi, Norihiko Akao, Koichi Okamoto
A 77-year-old man showed an asymptomatic meningeal lesion beneath the dura matter in the left fronto-parietal region on MRI during an examination for recurrent hoarsness. The lesion showed no gadolinium enhancement, and extended to neither the sulci nor skull. Neurological examinations revealed hoarseness, cochlear and vestibular dysfunction of the right ear, and mildly decreased Achilles tendon reflexes bilaterally. Laboratory findings showed marked inflammatory responses, but no abnormalities for LDH, IgG4, angiotensin-converting enzyme, or soluble IL-2 receptor...
May 26, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28528280/aortic-involvement-in-relapsing-polychondritis
#12
Maëlle Le Besnerais, Laurent Arnaud, Jonathan Boutémy, Boris Bienvenu, Hervé Lévesque, Zahir Amoura, Isabelle Marie
OBJECTIVE: To assess prevalence of aortic involvement in relapsing polychondritis (RP) patients; to evaluate clinical features and long-term outcome of RP patients exhibiting aortitis, aortic ectasia and/or aneurysm. METHODS: 172 RP patients underwent aortic computed tomography (CT)-scan; they were seen in 3 medical centers. RESULTS: 11 patients (6.4%) had aortic involvement, occurring within a median time of 2 years after RP diagnosis. CT-scan showed isolated aortitis (n=2); the 9 other patients exhibited: aortitis and aortic aneurysm (n=2) or ectasia (n=1), isolated aortic aneurysm (n=4) or ectasia (n=2); aortic localizations were as follows: thoracic (n=6), abdominal (n=2), thoracic and abdominal (n=4) aorta...
May 17, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28502337/successful-treatment-of-central-nervous-system-vasculitis-associated-with-relapsing-polychondritis-with-cyclophosphamide
#13
Maha Almackenzie, Ahmad Alharbi, Sharifa Alhassan, Eleanor Cook, Nezam Altorok
No abstract text is available yet for this article.
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28463837/adoptive-cellular-gene-therapy-for-the-treatment-of-experimental-autoimmune-polychondritis-ear-disease
#14
Bin Zhou, Yonggan Liao, Yunkai Guo, Ingo H Tarner, Chunfen Liao, Sisi Chen, Mohammad Habiby Kermany, Hanjun Tu, Sen Zhong, Peijie Chen
In the past, the clinical therapy for autoimmune diseases, such as autoimmune polychondritis ear disease, was mostly limited to nonspecific immunosuppressive agents, which could lead to variable responses. Currently, gene therapy aims at achieving higher specificity and less adverse effects. This concept utilizes the adoptive transfer of autologous T cells that have been retrovirally transduced ex vivo to express and deliver immunoregulatory gene products to sites of autoimmune inflammation. In the animal model of collagen-induced autoimmune polychondritis ear disease (CIAPED), the adoptive transfer of IL-12p40-expressing collagen type II (CII)-specific CD4+ T-cell hybridomas resulted in a significantly lower disease incidence and severity compared with untreated or vector-only-treated animals...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28441810/-sudden-deafness-and-vertigo-as-starting-symptoms-of-relapsing-polychondritis-one-case-report
#15
J Liu, X Bie, J N Zhang
No abstract text is available yet for this article.
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28432170/calcified-cauliflower-ear-in-relapsing-polychondritis
#16
Vishnu Mohan, Sivasubramanium Bhavani, Sruthi Kapliyil Subramanian, Abhishek Maiti
No abstract text is available yet for this article.
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28411788/intralesional-corticosteroid-therapy-for-relapsing-polychondritis
#17
Matthew DaCunha, Laura-Catherine Christensen, Daniel Aires, Deede Liu
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28381327/autoimmune-related-nasal-septum-perforation-a-case-report-and-systematic-review
#18
Lohitha Guntupalli, Kunjan Patel, Farhoud Faraji, Joseph D Brunworth
BACKGROUND: Inflammatory injury of nasal respiratory mucosa is a common feature of multisystem autoimmune disease. Certain autoimmune disorders are associated with nasal septum perforation (NSP). We performed a systematic review of the literature to better understand the association of NSP with specific autoimmune disorders. This is a case report of a 29-year-old woman with a history of arthralgia, autoreactive antibody titers, platelet dysfunction, and NSP. The constellation of symptoms and potential familial involvement indicated that the NSP in this patient was an early sign of an autoimmune disorder, an unknown autoimmune disorder, or a known disease with incomplete penetrance...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28364136/relapsing-polychondritis-a-chameleon-among-orphan-diseases
#19
REVIEW
Sabine Schumacher, Herwig Pieringer
Relapsing polychondritis (RPC) is a rare disease with recurrent episodes of inflammation of cartilage tissue leading to fibrosis and organ damage. Despite unknown etiology, there is some evidence of a genetic predisposition. The clinical presentation is heterogeneous and an association with other autoimmune disorders such as rheumatoid arthritis or different forms of vasculitis has been described. All organ systems containing cartilage can be affected, such as ear, nose, joints, trachea, aorta, and coronary arteries...
March 31, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28361234/aseptic-meningitis-in-relapsing-polychondritis-a-case-report-and-literature-review
#20
REVIEW
Kai Shen, Geng Yin, Chenlu Yang, Qibing Xie
Aseptic meningitis is an extremely rare neurologic complication of relapsing polychondritis (RP). We reported a case of a 58-year-old Chinese female with intractable headache, puffy ears, pleocytosis, and cranial magnetic resonance imaging (MRI) showing thickened and enhanced meninges. She was finally diagnosed of aseptic meningitis due to RP after full exclusion of infectious causes. She gradually developed neurosensory hearing loss, vertigo, and saddle nose while glucocorticosteroid therapy and combined cyclophosphamide could not control her headache...
March 30, 2017: Clinical Rheumatology
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