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https://www.readbyqxmd.com/read/28439005/quantifying-the-influence-of-global-warming-on-unprecedented-extreme-climate-events
#1
Noah S Diffenbaugh, Deepti Singh, Justin S Mankin, Daniel E Horton, Daniel L Swain, Danielle Touma, Allison Charland, Yunjie Liu, Matz Haugen, Michael Tsiang, Bala Rajaratnam
Efforts to understand the influence of historical global warming on individual extreme climate events have increased over the past decade. However, despite substantial progress, events that are unprecedented in the local observational record remain a persistent challenge. Leveraging observations and a large climate model ensemble, we quantify uncertainty in the influence of global warming on the severity and probability of the historically hottest month, hottest day, driest year, and wettest 5-d period for different areas of the globe...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438760/use-of-the-hyperinsulinemic-euglycemic-clamp-to-assess-insulin-sensitivity-in-guinea-pigs-dose-response-partitioned-glucose-metabolism-and-species-comparisons
#2
Dane M Horton, David A Saint, Julie A Owens, Kathryn L Gatford, Karen L Kind
The guinea pig is an alternate small animal model for the study of metabolism, including insulin sensitivity. However, only one study to date has reported the use of the hyperinsulinemic-euglycemic clamp (HEC) in anaesthetized animals in this species, and the dose-response has not been reported. We therefore characterized the dose-response curve for whole-body glucose uptake using recombinant human insulin in the adult guinea pig. Inter-species comparisons with published data showed species differences in maximal whole body responses (guinea pig ≈ human < rat < mouse), and the insulin concentrations at which half-maximal insulin responses occurred (guinea pig > human ≈ rat > mouse)...
April 24, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28427908/transforming-the-health-care-experience-doctors-nurses-patients-and-beyond
#3
Trina Spear, Karen M Horton, Elliot K Fishman, Pamela T Johnson
No abstract text is available yet for this article.
April 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28424129/hospital-characteristics-affect-consent-and-conversion-rates-for-potential-organ-donors
#4
Jawad T Ali, Aileen Ebadat, Danilo Martins, Sadia Ali, Shannon Horton, Thomas B Coopwood, Carlos V R Brown
Consent and conversion rates of potential organ donors in the United States need to be maximized to match the number of individuals awaiting organ donation. Studies to date have not focused on characteristics of centers with better outcomes. We performed an 8-year (2006-2014) retrospective study of our local organ procurement organization database. We categorized hospitals in our region as academic centers versus nonacademic centers, trauma centers versus nontrauma centers, and large (≥400 beds) centers versus small (<400 beds) centers...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28422015/offline-when-the-lancet-went-to-the-vatican
#5
Richard Horton
No abstract text is available yet for this article.
April 15, 2017: Lancet
https://www.readbyqxmd.com/read/28419486/population-pharmacokinetic-analysis-of-bortezomib-in-pediatric-leukemia-patients-model-based-support-for-body-surface-area-based-dosing-over-the-2-to-16-year-age-range
#6
Michael J Hanley, Diane R Mould, Timothy J Taylor, Neeraj Gupta, Kaveri Suryanarayan, Rachel Neuwirth, Dixie-Lee Esseltine, Terzah M Horton, Richard Aplenc, Todd A Alonzo, Xiaomin Lu, Ashley Milton, Karthik Venkatakrishnan
This population analysis described the pharmacokinetics of bortezomib after twice-weekly, repeat-dose, intravenous administration in pediatric patients participating in 2 clinical trials: the phase 2 AALL07P1 (NCT00873093) trial in relapsed acute lymphoblastic leukemia and the phase 3 AAML1031 (NCT01371981) trial in de novo acute myelogenous leukemia. The sources of variability in the pharmacokinetic parameters were characterized and quantified to support dosing recommendations. Patients received intravenous bortezomib 1...
April 18, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28417438/examining-the-support-peer-supporters-provide-using-structural-equation-modeling-nondirective-and-directive-support-in-diabetes-management
#7
Sarah D Kowitt, Guadalupe X Ayala, Andrea L Cherrington, Lucy A Horton, Monika M Safford, Sandra Soto, Tricia S Tang, Edwin B Fisher
BACKGROUND: Little research has examined the characteristics of peer support. Pertinent to such examination may be characteristics such as the distinction between nondirective support (accepting recipients' feelings and cooperative with their plans) and directive (prescribing "correct" choices and feelings). PURPOSE: In a peer support program for individuals with diabetes, this study examined (a) whether the distinction between nondirective and directive support was reflected in participants' ratings of support provided by peer supporters and (b) how nondirective and directive support were related to depressive symptoms, diabetes distress, and Hemoglobin A1c (HbA1c)...
April 17, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28411330/a-restorative-yoga-intervention-for-african-american-breast-cancer-survivors-a-pilot-study
#8
Teletia R Taylor, Judith Barrow, Kepher Makambi, Vanessa Sheppard, Sherrie Flynt Wallington, Chloe Martin, Danyella Greene, Sri Lakshmi Hyndavi Yeruva, Sara Horton
BACKGROUND: Data show that yoga is effective for improving health-related outcomes in breast cancer survivors. While breast cancer is the most commonly diagnosed cancer among African-American women (AAW), AAW are less likely to engage in yoga compared to other ethnic groups. The goals of the current study were to assess the feasibility of an 8-week restorative yoga program among African-American breast cancer survivors (AA BCS). Specifically, study aims were to (1) measure changes in study outcomes in a restorative yoga (RY) group compared to a wait list control group, (2) assess adherence to the RY program, and (3) assess program satisfaction among study participants...
April 14, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28408087/public-health-science-conference-a-call-for-abstracts
#9
Serena Luchenski, Robert W Aldridge, Simon Capewell, Felix Greaves, Anne M Johnson, Ronan A Lyons, Paul Lincoln, Martin McKee, Klim McPherson, Helen Walters, Richard Horton
No abstract text is available yet for this article.
April 10, 2017: Lancet
https://www.readbyqxmd.com/read/28403882/pathobiological-investigation-of-naturally-infected-canine-rabies-cases-from-sri-lanka
#10
S Beck, P Gunawardena, D L Horton, D J Hicks, D A Marston, A Ortiz-Pelaez, A R Fooks, A Núñez
BACKGROUND: The recommended screening of rabies in 'suspect' animal cases involves testing fresh brain tissue. The preservation of fresh tissue however can be difficult under field conditions and formalin fixation provides a simple alternative that may allow a confirmatory diagnosis. The occurrence and location of histopathological changes and immunohistochemical (IHC) labelling for rabies in formalin fixed paraffin embedded (FFPE) canine brain is described in samples from 57 rabies suspect cases from Sri-Lanka...
April 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28402810/offline-science-and-the-defeat-of-fear
#11
Richard Horton
No abstract text is available yet for this article.
April 8, 2017: Lancet
https://www.readbyqxmd.com/read/28402809/the-lancet-child-adolescent-health-a-call-for-papers-for-a-new-journal
#12
Jane Godsland, Udani Samarasekera, Esther Lau, Richard Horton
No abstract text is available yet for this article.
April 8, 2017: Lancet
https://www.readbyqxmd.com/read/28401608/putting-knowledge-to-work-in-clinical-practice-understanding-experiences-of-preceptorship-as-outcomes-of-interconnected-domains-of-learning
#13
Helen Therese Allan, Carin Magnusson, Karen Evans, Khim Horton, Kathy Curtis, E Ball, Martin Johnson
AIM: To explore how preceptor support can assist newly qualified nurses (NQNs) to put knowledge to work across interconnected forms of knowledge when delegating to health care assistants (HCAs). BACKGROUND: Current literature on preceptorship in nursing has failed to explore how competence is underpinned by knowledge frameworks in clinical practice. DESIGN: An ethnographic case study in three hospital sites in England (2011-2014). METHODS: Data collection included participant observation, interviews with 33 newly qualified nurses, 10 HCAs and 12 ward managers...
April 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28396608/zero-tolerance-biosecurity-protects-high-conservation-value-island-nature-reserve
#14
John K Scott, Simon J McKirdy, Johann van der Merwe, Roy Green, Andrew A Burbidge, Greg Pickles, Darryl C Hardie, Keith Morris, Peter G Kendrick, Melissa L Thomas, Kristin L Horton, Simon M O'Connor, Justin Downs, Richard Stoklosa, Russell Lagdon, Barbara Marks, Malcolm Nairn, Kerrie Mengersen
Barrow Island, north-west coast of Australia, is one of the world's significant conservation areas, harboring marsupials that have become extinct or threatened on mainland Australia as well as a rich diversity of plants and animals, some endemic. Access to construct a Liquefied Natural Gas (LNG) plant, Australia's largest infrastructure development, on the island was conditional on no non-indigenous species (NIS) becoming established. We developed a comprehensive biosecurity system to protect the island's biodiversity...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395910/disparities-in-receipt-of-family-planning-services-by-disability-status-new-estimates-from-the-national-survey-of-family-growth
#15
William Mosher, Tina Bloom, Rosemary Hughes, Leah Horton, Ramin Mojtabai, Jeanne L Alhusen
BACKGROUND: A substantial and increasing population of US women of childbearing age live with disability. Disability-based disparities in access to family planning services have been previously documented, but few studies have used population-based data sources or evidence-based measures of disability. OBJECTIVE: To determine population-based estimates of use of family planning services among women 15-44 years of age in the United States, and to examine differences by disability status...
April 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28393757/prehospital-randomised-assessment-of-a-mechanical-compression-device-in-out-of-hospital-cardiac-arrest-paramedic-a-pragmatic-cluster-randomised-trial-and-economic-evaluation
#16
Simon Gates, Ranjit Lall, Tom Quinn, Charles D Deakin, Matthew W Cooke, Jessica Horton, Sarah E Lamb, Anne-Marie Slowther, Malcolm Woollard, Andy Carson, Mike Smyth, Kate Wilson, Garry Parcell, Andrew Rosser, Richard Whitfield, Amanda Williams, Rebecca Jones, Helen Pocock, Nicola Brock, John Jm Black, John Wright, Kyee Han, Gary Shaw, Laura Blair, Joachim Marti, Claire Hulme, Christopher McCabe, Silviya Nikolova, Zenia Ferreira, Gavin D Perkins
BACKGROUND: Mechanical chest compression devices may help to maintain high-quality cardiopulmonary resuscitation (CPR), but little evidence exists for their effectiveness. We evaluated whether or not the introduction of Lund University Cardiopulmonary Assistance System-2 (LUCAS-2; Jolife AB, Lund, Sweden) mechanical CPR into front-line emergency response vehicles would improve survival from out-of-hospital cardiac arrest (OHCA). OBJECTIVE: Evaluation of the LUCAS-2 device as a routine ambulance service treatment for OHCA...
March 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28393373/a-population-based-approach-to-analyzing-pulses-in-time-series-of-hormone-data
#17
K W Horton, N E Carlson, G K Grunwald, M J Mulvahill, A J Polotsky
Studies of reproductive physiology involve rapid sampling protocols that result in time series of hormone concentrations. The signature pattern in these times series is pulses of hormone release. Various statistical models for quantifying the pulsatile release features exist. Currently these models are fitted separately to each individual and the resulting estimates averaged to arrive at post hoc population-level estimates. When the signal-to-noise ratio is small or the time of observation is short (e.g., 6 h), this two-stage estimation approach can fail...
April 9, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28391872/the-political-argument-for-investing-in-global-health
#18
Keith Martin, Zoë Mullan, Richard Horton
No abstract text is available yet for this article.
April 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28391752/low-intensity-pulsed-ultrasound-for-nonoperative-treatment-of-scaphoid-nonunions-a-meta-analysis
#19
Edward W Seger, Julio J Jauregui, Steven A Horton, Gerardo Davalos, Erika Kuehn, Michael A Stracher
BACKGROUND: Scaphoid fractures progress to nonunion rates of up to 15% when non-displaced, and are even more frequent when the fracture is displaced. Standard treatment in these cases is surgery; however, individuals unable to undergo this operation, or for those who wish to try more conservative measures, there may be benefit from nonoperative options. Of these, low-intensity pulsed ultrasound (LIPUS) has been shown to improve fracture nonunion healing. The purpose of this study was to perform a comprehensive meta-analysis of relevant literature to determine success of the use of LIPUS for treatment of scaphoid nonunion...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28383527/activation-of-the-hypoglossal-to-tongue-musculature-motor-pathway-by-remote-control
#20
Garret A Horton, Jimmy J Fraigne, Zoltan A Torontali, Matthew B Snow, Jennifer L Lapierre, Hattie Liu, Gaspard Montandon, John H Peever, Richard L Horner
Reduced tongue muscle tone precipitates obstructive sleep apnea (OSA), and activation of the tongue musculature can lessen OSA. The hypoglossal motor nucleus (HMN) innervates the tongue muscles but there is no pharmacological agent currently able to selectively manipulate a channel (e.g., Kir2.4) that is highly restricted in its expression to cranial motor pools such as the HMN. To model the effect of manipulating such a restricted target, we introduced a "designer" receptor into the HMN and selectively modulated it with a "designer" drug...
April 6, 2017: Scientific Reports
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