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https://www.readbyqxmd.com/read/29148114/on-the-character-and-production-of-active-participation-in-neuro-rehabilitation-an-actor-network-perspective
#1
Simon Horton, Kathryn Mares, Neil Coull, Fiona Poland
The importance of patients' active involvement in neuro-rehabilitation after acquired brain injury has been consistently emphasised in recent years. However, most approaches fail to show how 'active participation' is practically enacted, focusing on individualised explanations of patient choice and behaviours, or notions of inherent patient traits. Using actor-network theory (ANT) as a sensitising concept, we investigated neuro-rehabilitation practices, asking how participation is shaped through biological and socio-material specificities, how rights to knowledge and expertise are constructed, and how a body acclimatises and adjusts within an order of participation and transformation...
November 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29143745/offline-planetary-health-s-next-frontier-biodiversity
#2
Richard Horton
No abstract text is available yet for this article.
November 11, 2017: Lancet
https://www.readbyqxmd.com/read/29141140/n-heterocyclic-carbene-self-assembled-monolayers-on-gold-as-surface-plasmon-resonance-biosensors
#3
Zhijun Li, Kim A Munro, Iraklii I Ebralidze, Mina R Narouz, J Daniel Padmos, Hongxia Hao, Cathleen M Crudden, J Hugh Horton
Surface plasmon resonance (SPR)-based biosensing is a powerful tool to study the recognition processes between biomole-cules in real-time without need for labels. The use of thiol chemistry is a critical component in surface functionalization of various SPR biosensor surfaces on gold. However, its use is hampered by the high propensity for oxidation of the gold-thiol linkage even in ambient atmosphere, resulting in a short lifetime of SPR sensor chips unless strict precautions are taken. Herein, we describe an approach to overcome this limitation by employing highly robust self-assembled monolayers (SAMs) of alkylated N-heterocyclic carbenes (NHCs) on gold...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29136119/the-bat-as-a-new-model-of-cortical-development
#4
Verónica Martínez-Cerdeño, Jasmin Camacho, Jeanelle Ariza, Hailee Rogers, Kayla Horton-Sparks, Anna Kreutz, Richard Behringer, John J Rasweiler, Stephen C Noctor
The organization of the mammalian cerebral cortex shares fundamental features across species. However, while the radial thickness of grey matter varies within one order of magnitude, the tangential spread of the cortical sheet varies by orders of magnitude across species. A broader sample of model species may provide additional clues for understanding mechanisms that drive cortical expansion. Here, we introduce the bat Carollia perspicillata as a new model species. The brain of C. perspicillata is similar in size to that of mouse but has a cortical neurogenic period at least 5 times longer than mouse, and nearly as long as that of the rhesus macaque, whose brain is 100 times larger...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29135785/comparison-of-polar-m600-optical-heart-rate-and-ecg-heart-rate-during-exercise
#5
John F Horton, Pro Stergiou, Tak S Fung, Larry Katz
PURPOSE: The purpose of this study was to evaluate the accuracy of the Polar M600 optical heart rate (OHR) sensor compared with ECG heart rate (HR) measurement during various physical activities. METHODS: Thirty-six subjects participated in a continuous 76-min testing session, which included rest, cycling warm-up, cycling intervals, circuit weight training, treadmill intervals, and recovery. HR was measured using a three-lead ECG configuration and a Polar M600 Sport Watch on the left wrist...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134379/how-low-can-we-go-and-should-we-risk-reduction-for-minimal-volume-dcis
#6
EDITORIAL
Marc D Ryser, Janet K Horton, E Shelley Hwang
No abstract text is available yet for this article.
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29133438/normal-topography-and-binocularity-of-the-superior-colliculus-in-strabismus
#7
John R Economides, Brittany C Rapone, Daniel L Adams, Jonathan C Horton
In subjects with alternating strabismus either eye can be used to saccade to visual targets. The brain must calculate the correct vector for each saccade, which will depend on the eye chosen to make it. The superior colliculus, a major midbrain center for saccade generation, was examined to determine if the maps serving each eye were shifted to compensate for strabismus.Alternating exotropia was induced in two male macaques at age one month by sectioning the tendons of the medial recti. Once the animals grew to maturity, they were trained to fixate targets with either eye...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29131785/offline-america-the-fourth-world
#8
Richard Horton
No abstract text is available yet for this article.
October 7, 2017: Lancet
https://www.readbyqxmd.com/read/29124913/measurement-of-lying-and-standing-blood-pressure-in-hospital
#9
Shelagh O'Riordan, Naomi Vasilakis, Labib Hussain, Rowena Schoo, Julie Whitney, Julie Windsor, Khim Horton, Finbarr Martin
Measuring lying and standing blood pressure (BP) is an important clinical observation in older hospital inpatients. This is because a drop in BP on standing, known as orthostatic hypotension (OH) is common in older people and in acute illness and, therefore, in hospital patients. OH increases the risk of a fall in hospital. Simple measures such as changes in medication or rehydration can reduce this drop in BP and reduce the risk of falls. In a recent snapshot audit in England and Wales of 179 acute hospitals and 4,846 patients aged 65 years and over admitted with an acute illness, only 16% had a lying and standing BP recorded within 48 hours...
September 29, 2017: Nursing Older People
https://www.readbyqxmd.com/read/29115235/offline-medicine-and-marx
#10
Richard Horton
No abstract text is available yet for this article.
November 4, 2017: Lancet
https://www.readbyqxmd.com/read/29115219/offline-dr-tedros-robert-mugabe-and-who
#11
Richard Horton
No abstract text is available yet for this article.
October 28, 2017: Lancet
https://www.readbyqxmd.com/read/29111711/formal-total-synthesis-of-c9-deoxyomuralide-from-l-leucine-using-a-double-sacrificial-chirality-transfer-approach
#12
Philip C Bulman Page, Ross L Goodyear, Alexandra E Horton, Yohan Chan, Rehana Karim, Maria A O'Connell, Christopher Hamilton, Alexandra M Z Slawin, Benjamin R Buckley, Steven Mark Allin
Formal stereocontrolled syntheses of (±)- and (+)-C9-deoxyomuralide is reported, constituting one of the shortest routes to the full carbon skeleton reported to date.
November 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29106425/siloxane-based-linkers-in-the-construction-of-hydrogen-bonded-assemblies-and-porous-3d-mofs
#13
Luke C Delmas, Peter N Horton, Andrew J P White, Simon J Coles, Paul D Lickiss, Robert P Davies
A siloxane-based hexacarboxylic acid (L1-H6) has been prepared and applied in MOF construction. L1-H6 itself crystallizes as an unusual interpenetrated 3D hydrogen-bonded framework. Reaction of L1-H6 with Zn(ii) gave IMP-18 - a 3D MOF incorporating Si-O-Si functionality. Cleavage of L1-H6 gives a silanol-based triacid which is shown to give a coordination polymer (IMP-19) with Zn(ii).
November 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29103847/5-year-outcomes-after-left%C3%A2-atrial%C3%A2-appendage-closure-from-the-prevail-and-protect-af-trials
#14
Vivek Y Reddy, Shephal K Doshi, Saibal Kar, Douglas N Gibson, Matthew J Price, Kenneth Huber, Rodney P Horton, Maurice Buchbinder, Petr Neuzil, Nicole T Gordon, David R Holmes
BACKGROUND: The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, St. Paul, Minnesota) was equivalent to warfarin for preventing stroke in atrial fibrillation, but had a high rate of complications. In a second randomized trial, PREVAIL (Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy), the complication rate was low...
November 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29102562/prostaglandin-e2-increases-lentiviral-vector-transduction-efficiency-of-adult-human-hematopoietic-stem-and-progenitor-cells
#15
Garrett C Heffner, Melissa Bonner, Lauryn Christiansen, Francis J Pierciey, Dakota Campbell, Yegor Smurnyy, Wenliang Zhang, Amanda Hamel, Seema Shaw, Gretchen Lewis, Kendrick A Goss, Olivia Garijo, Bruce E Torbett, Holly Horton, Mitchell H Finer, Philip D Gregory, Gabor Veres
Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34(+) hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E2 (PGE2) as a positive mediator of lentiviral transduction of CD34(+) cells. Supplementation with PGE2 increased lentiviral vector (LVV) transduction of CD34(+) cells approximately 2-fold compared to control transduction methods with no effect on cell viability. Transduction efficiency was consistently increased in primary CD34(+) cells from multiple normal human donors and from patients with β-thalassemia or sickle cell disease...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29100041/dna-polymerase-%C3%AE-a-missing-link-of-the-base-excision-repair-machinery-in-mammalian-mitochondria
#16
Rajendra Prasad, Melike Çağlayan, Da-Peng Dai, Cristina A Nadalutti, Ming-Lang Zhao, Natalie R Gassman, Agnes K Janoshazi, Donna F Stefanick, Julie K Horton, Rachel Krasich, Matthew J Longley, William C Copeland, Jack D Griffith, Samuel H Wilson
Mitochondrial genome integrity is fundamental to mammalian cell viability. Since mitochondrial DNA is constantly under attack from oxygen radicals released during ATP production, DNA repair is vital in removing oxidatively generated lesions in mitochondrial DNA, but the presence of a strong base excision repair system has not been demonstrated. Here, we addressed the presence of such a system in mammalian mitochondria involving the primary base lesion repair enzyme DNA polymerase (pol) β. Pol β was localized to mammalian mitochondria by electron microscopic-immunogold staining, immunofluorescence co-localization and biochemical experiments...
October 28, 2017: DNA Repair
https://www.readbyqxmd.com/read/29100039/xrcc1-mediated-repair-of-strand-breaks-independent-of-pnkp-binding
#17
Julie K Horton, Donna F Stefanick, Ming-Lang Zhao, Agnes K Janoshazi, Natalie R Gassman, Hannah J Seddon, Samuel H Wilson
Repair of DNA-protein crosslinks and oxidatively damaged DNA base lesions generates intermediates with nicks or gaps with abnormal and blocked 3'-phosphate and 5'-OH ends that prevent the activity of DNA polymerases and ligases. End cleaning in mammalian cells by Tdp1 and PNKP produces the conventional 3'-OH and 5'-phosphate DNA ends suitable for completion of repair. This repair function of PNKP is facilitated by its binding to the scaffold protein XRCC1, and phosphorylation of XRCC1 by CK2 at several consensus sites enables PNKP binding and recruitment to DNA damage...
October 19, 2017: DNA Repair
https://www.readbyqxmd.com/read/29097422/intratumoral-cd8-t-cell-apoptosis-is-a-major-component-of-t-cell-dysfunction-and-impedes-anti-tumor-immunity
#18
Brendan L Horton, Jason B Williams, Alexandra Cabanov, Stefani Spranger, Thomas F Gajewski
Subsets of human tumors are infiltrated with tumor antigen-specific CD8(+) T cells (TILs) despite tumor progression. These TILs are thought to be inactivated by the immunosuppressive tumor microenvironment, through the engagement of inhibitory receptors such as CTLA-4 and PD-1. However, antigen-specific CD8+ TILs are not functionally inert, but are undergoing activation in situ. Here, we show that antigen-specific CD8(+) TIL are actively proliferating, yet also undergo high rates of apoptosis, leading to a vicious cycle of activation and death that limits immune efficacy...
November 2, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29092477/calibration-of-neutron-detectors-on-the-joint-european-torus
#19
Paola Batistoni, S Popovichev, S Conroy, I Lengar, A Čufar, M Abhangi, L Snoj, L Horton
The present paper describes the findings of the calibration of the neutron yield monitors on the Joint European Torus (JET) performed in 2013 using a (252)Cf source deployed inside the torus by the remote handling system, with particular regard to the calibration of fission chambers which provide the time resolved neutron yield from JET plasmas. The experimental data obtained in toroidal, radial, and vertical scans are presented. These data are first analysed following an analytical approach adopted in the previous neutron calibrations at JET...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29082871/offline-aids-learning-from-history-and-human-beings
#20
Richard Horton
No abstract text is available yet for this article.
October 21, 2017: Lancet
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