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https://www.readbyqxmd.com/read/28924616/soil-transmitted-helminth-infections-are-not-associated-with-compromised-antibody-responses-to-previously-administered-measles-and-tetanus-vaccines-among-hiv-1-infected-art-na%C3%A3-ve-kenyan-adults
#1
Helen L Storey, Benson Singa, Jackie Naulikha, Helen Horton, Barbra A Richardson, Grace John-Stewart, Judd L Walson
In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods...
February 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/28922385/metabolomics-analyses-identify-platelet-activating-factors-and-heme-breakdown-products-as-lassa-fever-biomarkers
#2
Trevor V Gale, Timothy M Horton, Donald S Grant, Robert F Garry
Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case management. The small molecule profile of serum from febrile patients triaged to the Viral Hemorrhagic Fever Ward at Kenema Government Hospital in Sierra Leone was assessed using untargeted Ultra High Performance Liquid Chromatography Mass Spectrometry. Physiological dysregulation resulting from Lassa virus (LASV) infection occurs at the small molecule level...
September 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28920887/the-chronic-and-evolving-neurological-consequences-of-traumatic-brain-injury
#3
REVIEW
Lindsay Wilson, William Stewart, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Lindsay Horton, David K Menon, Suzanne Polinder
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28918010/corrigendum-to-extending-the-distributed-lag-model-framework-to-handle-chemical-mixtures-environ-res-156-2017-253-264
#4
Ghalib A Bello, Manish Arora, Christine Austin, Megan K Horton, Robert O Wright, Chris Gennings
No abstract text is available yet for this article.
September 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/28917961/africa-and-health-a-commission-to-accelerate-success
#5
Richard Horton, Selina Lo
No abstract text is available yet for this article.
September 13, 2017: Lancet
https://www.readbyqxmd.com/read/28915337/the-cost-and-cost-effectiveness-of-childhood-cancer-treatment-in-el-salvador-central-america-a-report-from-the-childhood-cancer-2030-network
#6
Soad Fuentes-Alabi, Nickhill Bhakta, Roberto Franklin Vasquez, Sumit Gupta, Susan E Horton
BACKGROUND: Although previous studies have examined the cost of treating individual childhood cancers in low-income and middle-income countries, to the authors' knowledge none has examined the overall cost and cost-effectiveness of operating a childhood cancer treatment center. Herein, the authors examined the cost and sources of financing of a pediatric cancer unit in Hospital Nacional de Ninos Benjamin Bloom in El Salvador, and make estimates of cost-effectiveness. METHODS: Administrative data regarding costs and volumes of inputs were obtained for 2016 for the pediatric cancer unit...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28911917/after-asthma-airways-diseases-need-a-new-name-and-a-revolution
#7
Sabine Kleinert, Richard Horton
No abstract text is available yet for this article.
September 11, 2017: Lancet
https://www.readbyqxmd.com/read/28911288/impact-of-thrombelastography-in-paediatric-intensive-care
#8
B G Carter, E Carland, P Monagle, S B Horton, W Butt
We assessed the clinical impact of thrombelastography (TEG®) results (TEG® 5000, Haemonetics Corporation, Braintree, MA, USA) by measuring their ability to cause changes in a theoretical treatment plan and contribute to the understanding of haemostasis. We prospectively included paediatric intensive care unit (PICU) patients who had standard tests of haemostasis and TEG ordered and had an arterial catheter or extracorporeal access port in situ. Blood for standard tests and TEG was taken simultaneously. Independent of patient care, general patient information and results of standard laboratory tests were presented to five clinicians who were asked to document their theoretical treatment plan...
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28901926/offline-north-korea-the-case-for-health-diplomacy
#9
Richard Horton
No abstract text is available yet for this article.
September 9, 2017: Lancet
https://www.readbyqxmd.com/read/28895229/crisis-and-change-the-making-of-a-french-fda
#10
Constance A Nathanson, Henri Bergeron
Policy Points: Introducing a recent special issue of The Lancet on the health system in France, Horton and Ceschia observe that "the dominance of English as the language of science and, increasingly, global health too often closes the door on the history and experiences of others."(1) In that spirit, this manuscript presents a detailed case study of public health policy transformation in France in the early 1990s. It casts light on processes of policy change in a political and cultural environment very different from that of the United States, showing how the public health policy process is shaped by multiple contingencies of history, ideology, and politics...
September 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/28893402/a-large-scale-investigation-of-microplastic-contamination-abundance-and-characteristics-of-microplastics-in-european-beach-sediment
#11
Froukje A E Lots, Paul Behrens, Martina G Vijver, Alice A Horton, Thijs Bosker
Here we present the large-scale distribution of microplastic contamination in beach sediment across Europe. Sediment samples were collected from 23 locations across 13 countries by citizen scientists, and analysed using a standard operating procedure. We found significant variability in the concentrations of microplastics, ranging from 72±24 to 1512±187 microplastics per kg of dry sediment, with high variability within sampling locations. Three hotspots of microplastic accumulation (>700 microplastics per kg of dry sediment) were found...
September 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28891904/a-patient-information-leaflet-reduces-parental-anxiety-before-their-child-s-first-craniofacial-multidisciplinary-outpatient-appointment
#12
Thomas Edward Pidgeon, Christopher David Blore, Yasmin Webb, Jo Horton, Martin Evans
INTRODUCTION: It is expected that a child's first outpatient appointment with a craniofacial multidisciplinary team (MDT) instills anxiety in parents. Limited data exist on the aspects of the appointment that parents are most concerned about and what information they desire. The effect of written information provision on this cohort is unstudied. METHODS: Parents attending their child's first outpatient appointment with the Birmingham Children's Hospital Craniofacial MDT between September and December 2012 completed a questionnaire to identify concerns they had relating to the appointment...
September 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28879566/success-rate-and-complications-of-sharp-recanalization-for-treatment-of-central-venous-occlusions
#13
Emil I Cohen, Christopher Beck, Jesse Garcia, Ryan Muller, Hyun J Bang, Keith M Horton, Farris Hakki
PURPOSE: To evaluate success and safety of needle (sharp) recanalization as a method to re-establish access in patients with chronic central venous occlusions. MATERIALS AND METHODS: Thirty-nine consecutive patients who underwent this procedure were retrospectively reviewed to establish success rate and associated complications. In all cases, a 21- or 22-gauge needle was used to restore connection between two chronically occluded segments after conventional wire and catheter techniques had failed...
September 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28877476/mtorc2-signaling-selectively-regulates-the-generation-and-function-of-tissue-resident-peritoneal-macrophages
#14
Min-Hee Oh, Samuel L Collins, Im-Hong Sun, Ada J Tam, Chirag H Patel, Matthew L Arwood, Yee Chan-Li, Jonathan D Powell, Maureen R Horton
Tissue-resident macrophages play critical roles in sentinel and homeostatic functions as well as in promoting inflammation and immunity. It has become clear that the generation of these cells is highly dependent upon tissue-specific cues derived from the microenvironment that, in turn, regulate unique differentiation programs. Recently, a role for GATA6 has emerged in the differentiation programming of resident peritoneal macrophages. We identify a critical role for mTOR in integrating cues from the tissue microenvironment in regulating differentiation and metabolic reprogramming...
September 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28877461/acetyl-coa-carboxylase-inhibition-reduces-hepatic-steatosis-but-elevates-plasma-triglycerides-in-mice-and-humans-a-bedside-to-bench-investigation
#15
Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N Anderson, Stanislaw Deja, Xiaorong Fu, Shawn C Burgess, Cai Li, Marcie Ruddy, Manu Chakravarthy, Steve Previs, Stuart Milstein, Kevin Fitzgerald, David E Kelley, Jay D Horton
No abstract text is available yet for this article.
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28877052/diagnostic-efficiency-in-digital-pathology-a-comparison-of-optical-versus-digital-assessment-in-510-surgical-pathology-cases
#16
Anne M Mills, Sarah E Gradecki, Bethany J Horton, Rebecca Blackwell, Christopher A Moskaluk, James W Mandell, Stacey E Mills, Helen P Cathro
Prior work has shown that digital images and microscopic slides can be interpreted with comparable diagnostic accuracy. Although accuracy has been well-validated, the interpretative time for digital images has scarcely been studied and concerns about efficiency remain a major barrier to adoption. We investigated the efficiency of digital pathology when compared with glass slide interpretation in the diagnosis of surgical pathology biopsy and resection specimens. Slides were pulled from 510 surgical pathology cases from 5 organ systems (gastrointestinal, gynecologic, liver, bladder, and brain)...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28872019/offline-terrorism-and-syria-a-crisis-of-the-world
#17
Richard Horton
No abstract text is available yet for this article.
September 2, 2017: Lancet
https://www.readbyqxmd.com/read/28857309/impact-of-the-black-triangle-label-on-prescribing-of-new-drugs-in-the-united-kingdom-lessons-for-the-united-states-at-a-time-of-deregulation
#18
Daniel B Horton, Tobias Gerhard, Amy Davidow, Brian L Strom
PURPOSE: Newly approved novel drugs in Europe receive a black triangle label to promote pharmacovigilance. With growing momentum for earlier drug approvals and reliance on real-world evidence, we studied if the black triangle label promotes more judicious prescribing. METHODS: We examined whether general practitioners prescribed escitalopram, tadalafil, and vardenafil with a black triangle more cautiously than the same or similar drugs without a black triangle in The Health Improvement Network (UK)...
August 31, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28854673/peculiar-citric-acid-cycle-of-hydrothermal-vent-chemolithoautotroph-hydrogenovibrio-crunogenus-and-insights-into-carbon-metabolism-by-obligate-autotrophs
#19
Ishtiaque Quasem, Alexandra N Achille, Brittany A Caddick, Travis A Carter, Camille Daniels, Jennifer A Delaney, Vedad Delic, Kimberly A Denton, Martina C Duran, Marianne K Fatica, Christopher M Ference, Julie P Galkiewicz, Ana M Garcia, Jacqueline D Hendrick, Steven A Horton, Mey S Kun, Phoebe W Koch, Tien Min Lee, Christie R McCabe, Sean McHale, Lauren D McDaniel, Damian M Menning, Kristy J Menning, Hamed Mirzaei-Souderjani, Salina Mostajabian, David A Nicholson, Courtney K Nugent, Nicholas P Osman, Desiree I Pappas, Andrea M Rocha, Karyna Rosario, Haydn Rubelmann, Julie A Schwartz, Kent W Seeley, Christopher M Staley, Elizabeth M Wallace, Terianne M Wong, Brian L Zielinski, Thomas E Hanson, Kathleen M Scott
The genome sequence of the obligate chemolithoautotroph Hydrogenovibrio crunogenus paradoxically predicts a complete oxidative citric acid cycle (CAC). This prediction was tested by multiple approaches including whole cell carbon assimilation to verify obligate autotrophy, phylogenetic analysis of CAC enzyme sequences and enzyme assays. Hydrogenovibrio crunogenus did not assimilate any of the organic compounds provided (acetate, succinate, glucose, yeast extract, tryptone). Enzyme activities confirmed that its CAC is mostly uncoupled from the NADH pool...
August 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28841251/procedural-findings-and-ablation-outcome-in-patients-with-atrial-fibrillation-referred-after-two-or-more-failed-catheter-ablations
#20
Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Domenico Giovanni Della Rocca, Eli Hamilton Morris, J David Burkhardt, Javier E Sanchez, Rodney Horton, G Joseph Gallinghouse, Richard Hongo, Salwa Beheiry, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
INTRODUCTION: This study reports the procedural findings and ablation outcome in AF patients referred after ≥2 failed PV isolation (PVI). METHODS: Three hundred and five consecutive AF patients referred after ≥2 PVI were included in the analysis. High-dose isoproterenol challenge was used to identify PV reconnection and non-PV triggers; the latter were ablated based on the operator's discretion during the index procedure. At the repeat procedure, non-PV triggers were ablated in all...
August 25, 2017: Journal of Cardiovascular Electrophysiology
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