Cameron G Hollands, Allison L Boyd, Xueli Zhao, Jennifer C Reid, Charisa Henly, Amro ElRafie, David Boylan, Emily Broder, Olivia Kalau, Paige Johnson, Alyssa Mark, Jamie McNicol, Anargyros Xenocostas, Tobias Berg, Ronan Foley, Michael Trus, Brian Leber, Alejandro Garcia-Horton, Clinton Campbell, Mickie Bhatia
Despite most acute myeloid leukemia (AML) patients entering remission following chemotherapy, outcomes remain poor due to surviving leukemic cells that contribute to relapse. The nature of these enduring cells is poorly understood. Here, through temporal single-cell transcriptomic characterization of AML hierarchical regeneration in response to chemotherapy, we reveal a cell population: AML regeneration enriched cells (RECs). RECs are defined by CD74/CD68 expression, and although derived from leukemic stem cells (LSCs), are devoid of stem/progenitor capacity...
March 23, 2024: Cell reports medicine