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https://www.readbyqxmd.com/read/28813578/incomitance-and-eye-dominance-in-intermittent-exotropia
#1
Daniel L Adams, John R Economides, Jonathan C Horton
Purpose: To determine if the deviation angle changes in subjects with intermittent exotropia as they alternate fixation between the right and left eye in primary gaze. Methods: In this prospective observational cohort study, 37 subjects with intermittent exotropia were tested for evidence of incomitance. The position of each eye was recorded with a video tracker during fixation on a small central target. A cover-uncover test was performed by occluding one eye with a shutter that passed infrared light, allowing continuous tracking of both eyes...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28811355/evidence-for-updating-the-core-domain-set-of-outcome-measures-for-juvenile-idiopathic-arthritis-report-from-a-special-interest-group-at-omeract-2016
#2
Esi M Morgan, Meredith P Riebschleger, Jennifer Horonjeff, Alessandro Consolaro, Jane E Munro, Susan Thornhill, Timothy Beukelman, Hermine I Brunner, Emily L Creek, Julia G Harris, Daniel B Horton, Daniel J Lovell, Melissa L Mannion, Judyann C Olson, Homaira Rahimi, Maria Chiara Gallo, Serena Calandra, Angelo Ravelli, Sarah Ringold, Susan Shenoi, Jennifer Stinson, Karine Toupin-April, Vibeke Strand, Clifton O Bingham
OBJECTIVE: The current Juvenile Idiopathic Arthritis (JIA) Core Set was developed in 1997 to identify the outcome measures to be used in JIA clinical trials using statistical and consensus-based techniques, but without patient involvement. The importance of patient/parent input into the research process has increasingly been recognized over the years. An Outcome Measures in Rheumatology (OMERACT) JIA Core Set Working Group was formed to determine whether the outcome domains of the current core set are relevant to those involved or whether the core set domains should be revised...
August 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28808868/effect-of-multimodal-analgesia-on-opioid-use-after-open-ventral-hernia-repair
#3
Jeremy A Warren, Caroline Stoddard, Ahan L Hunter, Anthony J Horton, Carlyn Atwood, Joseph A Ewing, Steven Pusker, Vito A Cancellaro, Kevin B Walker, William S Cobb, Alfredo M Carbonell, Robert R Morgan
BACKGROUND: There is limited data on enhanced recovery after surgery (ERAS) protocols after ventral hernia repair (VHR). This study reports the impact of multimodal analgesia on opioid use after open VHR. METHODS: Retrospective review of open VHR treated during the initial 6 months after ERAS implementation. Protocol focused on opioid sparing using intraoperative ketamine and/or lidocaine infusion, selective epidural anesthesia, and postoperative ketamine infusion, ketorolac, and acetaminophen...
August 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28807679/identification-and-characterization-of-5%C3%AE-cyprinol-sulfating-cytosolic-sulfotransferases-sults-in-the-zebrafish-danio-rerio
#4
Katsuhisa Kurogi, Maki Yoshihama, Austin Horton, Isaac T Schiefer, Matthew D Krasowski, Lee R Hagey, Frederick E Williams, Yoichi Sakakibara, Naoya Kenmochi, Masahito Suiko, Ming-Cheh Liu
5α-Cyprinol 27-sulfate is the major biliary bile salt present in cypriniform fish including the zebrafish (Danio rerio). The current study was designed to identify the zebrafish cytosolic sulfotransferase (Sult) enzyme(s) capable of sulfating 5α-cyprinol and to characterize the zebrafish 5α-cyprinol-sulfating Sults in comparison with human SULT2A1. Enzymatic assays using zebrafish homogenates showed 5α-cyprinol-sulfating activity. A systematic analysis, using a panel of recombinant zebrafish Sults, revealed two Sult2 subfamily members, Sult2st2 and Sult2st3, as major 5α-cyprinol-sulfating Sults...
August 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28797115/ranking-93-health-interventions-for-low-and-middle-income-countries-by-cost-effectiveness
#5
Susan Horton, Hellen Gelband, Dean Jamison, Carol Levin, Rachel Nugent, David Watkins
BACKGROUND: Cost-effectiveness rankings of health interventions are useful inputs for national healthcare planning and budgeting. Previous comprehensive rankings for low- and middle- income countries were undertaken in 2005 and 2006, accompanying the development of strategies for the Millennium Development Goals. We update the rankings using studies published since 2000, as strategies are being considered for the Sustainable Development Goals. METHODS: Expert systematic searches of the literature were undertaken for a broad range of health interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28792399/offline-medicines-leadership-britain-s-loss-europe-s-gain
#6
Richard Horton
No abstract text is available yet for this article.
July 29, 2017: Lancet
https://www.readbyqxmd.com/read/28780550/improving-discharge-care-the-potential-of-a-new-organisational-intervention-to-improve-discharge-after-hospitalisation-for-acute-stroke-a-controlled-before-after-pilot-study
#7
Dominique A Cadilhac, Nadine E Andrew, Enna Stroil Salama, Kelvin Hill, Sandy Middleton, Eleanor Horton, Ian Meade, Sarah Kuhle, Mark R Nelson, Rohan Grimley
OBJECTIVE: Provision of a discharge care plan and prevention therapies is often suboptimal. Our objective was to design and pilot test an interdisciplinary, organisational intervention to improve discharge care using stroke as the case study using a mixed-methods, controlled before-after observational study design. SETTING: Acute care public hospitals in Queensland, Australia (n=15). The 15 hospitals were ranked against a benchmark based on a composite outcome of three discharge care processes...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28780282/adolescent-insomnia-suicide-risk-and-the-interpersonal-theory-of-suicide
#8
Lucas Zullo, Sarah Horton, Michael Eaddy, Jessica King, Jennifer Hughes, Andrew Diederich, Betsy Kennard, Graham Emslie, Sunita Stewart
Although insomnia has been repeatedly linked with suicide ideation, the reason for the linkage is not clear. The Interpersonal Psychological Theory of Suicide (IPTS) proposes that three core variables (thwarted belongingness, perceived burdensomeness, and acquired capability) are the final common pathway for all risk factors for suicide ideation and behavior. Recent research has suggested that insomnia may be associated with suicide ideation independently of the IPTS. We examined cross-sectional data from 151 psychiatric inpatients (ages 12-17) to determine if the association between insomnia symptoms and a continuous measure of suicide risk (measured as increasingly severe ideation and plan) was explained by the framework of the IPTS...
July 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28774259/the-relationship-between-sleep-duration-and-glycemic-control-among-hispanic-adults-with-uncontrolled-type-2-diabetes
#9
Kelsie M Full, Emily A Schmied, Humberto Parada, Andrea Cherrington, Lucy A Horton, Guadalupe X Ayala
Purpose The purpose of this study was to examine the relationship between sleep duration and glycemic control in adult Hispanic patients with uncontrolled type 2 diabetes. Methods This cross-sectional study used baseline data from 317 Hispanic adults with uncontrolled type 2 diabetes who participated in a randomized controlled trial testing a peer support intervention to improve diabetes control. To be eligible, participants had to be 18 years or older and have A1C >7% in the 3 months prior to randomization...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28768177/acetyl-coa-carboxylase-inhibition-reduces-hepatic-steatosis-but-elevates-plasma-triglycerides-in-mice-and-humans-a-bedside-to-bench-investigation
#10
Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N Anderson, Stanislaw Deja, Xiaorong Fu, Shawn C Burgess, Cai Li, Manu Chakravarthy, Steve Previs, Stuart Milstein, Kevin Fitzgerald, David E Kelley, Jay D Horton
Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a liver-specific inhibitor of acetyl-CoA carboxylase (ACC1) and (ACC2), enzymes that produce malonyl-CoA for fatty acid synthesis. MK-4074 administered to subjects with hepatic steatosis for 1 month lowered lipogenesis, increased ketones, and reduced liver triglycerides by 36%. Unexpectedly, MK-4074 increased plasma triglycerides by 200%...
August 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28756402/comparison-of-a-structured-home-based-rehabilitation-programme-with-conventional-supervised-pulmonary-rehabilitation-a-randomised-non-inferiority-trial
#11
Elizabeth J Horton, Katy E Mitchell, Vicki Johnson-Warrington, Lindsay D Apps, Louise Sewell, Mike Morgan, Rod S Taylor, Sally J Singh
BACKGROUND: Standardised home-based pulmonary rehabilitation (PR) programmes offer an alternative model to centre-based supervised PR for which uptake is currently poor. We determined if a structured home-based unsupervised PR programme was non-inferior to supervised centre-based PR for participants with COPD. METHODS: A total of 287 participants with COPD who were referred to PR (187 male, mean (SD) age 68 (8.86) years, FEV1% predicted 48.34 (17.92)) were recruited...
July 29, 2017: Thorax
https://www.readbyqxmd.com/read/28751443/fda-approval-summary-rucaparib-for-the-treatment-of-patients-with-deleterious-brca-mutation-associated-advanced-ovarian-cancer
#12
Sanjeeve Balasubramaniam, Julia A Beaver, Sara Horton, Laura L Fernandes, Shenghui Tang, Hisani N Horne, Jinzhong Liu, Chao Liu, Sarah J Schrieber, Jingyu Yu, Pengfei Song, William Pierce, Kim J Robertson, Todd R Palmby, Haw-Jyh Chiu, Eunice Y Lee, Reena Philip, Robert Schuck, Rosane Charlab, Anamitro Banerjee, Xiao Hong Chen, Xing Wang, Kirsten B Goldberg, Rajeshwari Sridhara, Geoffrey Kim, Richard Pazdur
On December 19, 2016, the U.S. Food and Drug Administration granted accelerated approval to rucaparib (RUBRACA, Clovis Oncology, Inc.) for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. FDA also approved the FoundationFocus™ CDx BRCA test (Foundation Medicine Inc.), the first next-generation sequencing-based companion diagnostic, for identifying patients with advanced ovarian cancer eligible for treatment with rucaparib based on detection of deleterious BRCA1 and/or BRCA2 mutations in tumor tissue...
July 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28745593/offline-ncds-why-are-we-failing
#13
Richard Horton
No abstract text is available yet for this article.
July 22, 2017: Lancet
https://www.readbyqxmd.com/read/28745592/the-international-aids-society-lancet-commission-on-the-future-of-the-hiv-response-and-global-health
#14
Chris Beyrer, Pamela Das, Richard Horton, Owen Ryan, Linda-Gail Bekker
No abstract text is available yet for this article.
July 22, 2017: Lancet
https://www.readbyqxmd.com/read/28742087/type-1-skewed-neuroinflammation-and-vascular-damage-associated-with-orientia-tsutsugamushi-infection-in-mice
#15
Lynn Soong, Thomas R Shelite, Yan Xing, Harica Kodakandla, Yuejin Liang, Brandon J Trent, Paulina Horton, Kathryn C Smith, Zhenyang Zhao, Jiaren Sun, Donald H Bouyer, Jiyang Cai
BACKGROUND: Scrub typhus is a life-threatening disease, due to infection with O. tsutsugamushi, a Gram-negative bacterium that preferentially replicates in endothelial cells and professional phagocytes. Meningoencephalitis has been reported in scrub typhus patients and experimentally-infected animals; however, the neurological manifestation and its underlying mechanisms remain poorly understood. To address this issue, we focused on Orientia tsutsugamushi Karp strain (OtK), and examined host responses in the brain during lethal versus self-healing scrub typhus disease in our newly established murine models...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28739213/association-between-substance-use-disorder-and-polygenic-liability-to-schizophrenia
#16
Sarah M Hartz, Amy C Horton, Mary Oehlert, Caitlin E Carey, Arpana Agrawal, Ryan Bogdan, Li-Shiun Chen, Dana B Hancock, Eric O Johnson, Carlos N Pato, Michele T Pato, John P Rice, Laura J Bierut
BACKGROUND: There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology of this comorbidity. METHODS: We tested the hypothesis that shared genetic liability contributes to the high rates of comorbidity between schizophrenia and substance use disorder. To do this, polygenic risk scores for schizophrenia derived from a large meta-analysis by the Psychiatric Genomics Consortium were computed in three substance use disorder datasets: the Collaborative Genetic Study of Nicotine Dependence (ascertained for tobacco use disorder; n = 918 cases; 988 control subjects), the Collaborative Study on the Genetics of Alcoholism (ascertained for alcohol use disorder; n = 643 cases; 384 control subjects), and the Family Study of Cocaine Dependence (ascertained for cocaine use disorder; n = 210 cases; 317 control subjects)...
June 6, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28737119/passive-surveillance-of-united-kingdom-bats-for-lyssaviruses-2005-2015
#17
E L Wise, D A Marston, A C Banyard, H Goharriz, D Selden, N Maclaren, T Goddard, N Johnson, L M McElhinney, A Brouwer, J N Aegerter, G C Smith, D L Horton, A C Breed, A R Fooks
Passive surveillance for lyssaviruses in UK bats has been ongoing since 1987 and has identified 13 cases of EBLV-2 from a single species; Myotis daubentonii. No other lyssavirus species has been detected. Between 2005 and 2015, 10 656 bats were submitted, representing 18 species, creating a spatially and temporally uneven sample of British bat fauna. Uniquely, three UK cases originate from a roost at Stokesay Castle in Shropshire, England, where daily checks for grounded and dead bats are undertaken and bat carcasses have been submitted for testing since 2007...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28735854/prevention-and-management-of-dementia-a-priority-for-public-health
#18
Helen Frankish, Richard Horton
No abstract text is available yet for this article.
July 19, 2017: Lancet
https://www.readbyqxmd.com/read/28733303/oral-glucocorticoid-use-and-osteonecrosis-in-children-and-adults-with-chronic-inflammatory-diseases-a-population-based-cohort-study
#19
Daniel B Horton, Kevin Haynes, Michelle R Denburg, Mihir M Thacker, Carlos D Rose, Mary E Putt, Mary B Leonard, Brian L Strom
OBJECTIVES: We studied oral glucocorticoids and osteonecrosis, a rare but serious bone disease, in individuals with various chronic inflammatory diseases. We hypothesised that we would find stronger associations in adults versus children and in people with autoimmune diseases. DESIGN: Retrospective cohort study. SETTING: Population-representative data (1994-2013) from general practices in the UK. PARTICIPANTS: Children and adults diagnosed with asthma; inflammatory bowel disease; juvenile, psoriatic or rheumatoid arthritis; psoriasis; or systemic lupus...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28730947/safety-of-nitric-oxide-added-to-the-ecmo-circuit-a-pilot-study-in-children
#20
Roberto Chiletti, Steve Horton, Andrzej Bednarz, Robert Bartlett, Warwick Butt
We describe our experience of 30 consecutive children supported with ECMO and receiving 20 ppm of nitric oxide in the oxygenator of the ECMO circuit. Administration of nitric oxide into the ECMO circuit is safe and could potentially mitigate ischaemia reperfusion injury and end-organ dysfunction of children requiring mechanical support.
July 1, 2017: Perfusion
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