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asthma phenotypes

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https://www.readbyqxmd.com/read/29667580/severe-asthma-phenotypes-classified-by-site-of-airway-involvement-and-remodeling-via-chest-ct-scan
#1
S Kim, K Nam Jin, S H Cho, C Hyun Lee, H R Kang
BACKGROUND AND OBJECTIVE: This study aimed to establish a system that can classify severe asthma on the basis of airway remodeling patterns visualized by computed tomography (CT) images and to evaluate the clinical characteristics of individual image-based subtypes. METHODS: Chest CT images of severe asthma patients were retrospectively evaluated to classify phenotypes by site of airway involvement and remodeling. The association between radiologic subtypes and clinical characteristics was assessed...
April 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#2
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29665364/casticin-inhibits-pdgf-induced-proliferation-and-migration-of-airway-smooth-muscle-cells
#3
Ying Dai, Ruiduo Cheng, Jie Gao, Ying Li, Chunyan Lou, Yanyang Li
Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone), one of the main components from Vitex rotundifolia L., was reported to possess several pharmacological properties, including anti-inflammatory, hepatoprotective, anticancer, anti-asthma activities. However, the effects of casticin on airway smooth muscle cells (ASMCs) proliferation and migration have not been explored. This study aimed to evaluate the effects of casticin on the proliferation and migration of ASMCs, and study the possible molecular mechanism...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29664587/maternal-smoking-during-pregnancy-and-early-childhood-and-development-of-asthma-and-rhinoconjunctivitis-a-medall-project
#4
Jesse D Thacher, Ulrike Gehring, Olena Gruzieva, Marie Standl, Göran Pershagen, Carl-Peter Bauer, Dietrich Berdel, Theresa Keller, Sibylle Koletzko, Gerard H Koppelman, Inger Kull, Susanne Lau, Irina Lehmann, Dieter Maier, Tamara Schikowski, Ulrich Wahn, Alet H Wijga, Joachim Heinrich, Jean Bousquet, Josep M Anto, Andrea von Berg, Erik Melén, Henriette A Smit, Thomas Keil, Anna Bergström
BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium...
April 12, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29663825/clustering-analysis-in-asthmatic-outpatients-an-experience-in-clinical-practice
#5
Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, Fabio Luigi Massimo Ricciardolo
The present real-life study collected medical data from 186 asthmatics with a median age of 40 years. It gathered information on the asthma onset age, allergic rhinitis, comorbidities, smoking, BMI, and severity of respiratory symptoms. Afterwards, ascending hierarchical clustering analysis was performed and outcomes allowed to characterize three different asthma phenotypes. Interestingly, in clustering of asthma patients the most important factor was GINA asthma control scoring corresponding to the asthma control GINA grading...
April 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29662320/omalizumab-for-severe-asthma-toward-personalized-treatment-based-on-biomarker-profile-and-clinical-history
#6
REVIEW
Farnaz Tabatabaian, Dennis K Ledford
Asthma is a heterogeneous syndrome with numerous underlining molecular and inflammatory mechanisms contributing to the wide spectrum of clinical phenotypes. Multiple therapies targeting severe asthma with type 2 (T2) high inflammation are or soon will be available. T2 high inflammation is defined as inflammation associated with atopy or eosinophilia or an increase in cytokines associated with T-helper 2 lymphocytes. Omalizumab is a humanized anti-IgE monoclonal antibody and the first biologic therapy approved for moderate-severe allergic asthma...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29650557/sputum-proteomics-and-airway-cell-transcripts-of-current-and-ex-smokers-with-severe-asthma-in-u-biopred-an-exploratory-analysis
#7
Kentaro Takahashi, Stelios Pavlidis, Francois Ng Kee Kwong, Uruj Hoda, Christos Rossios, Kai Sun, Matthew Loza, Fred Baribaud, Pascal Chanez, Steve J Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Sven-Eric Dahlen, N Krug, Thomas Sandstrom, Dominic E Shaw, Rene Lutter, Per Bakke, Louise J Fleming, Peter H Howarth, Massimo Caruso, Ana R Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Ratko Djukanovic, Peter J Sterk, Yike Guo, Ian M Adcock, Kian Fan Chung
Background: Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes. Methods: The U-BIOPRED severe asthma patients containing current-smokers (CSA), ex-smokers (ESA), non-smokers (NSA) and healthy non-smokers (NH) was examined. Blood and sputum cell counts, fractional exhaled nitric oxide and spirometry were obtained. Exploratory proteomic analysis of sputum supernatants and transcriptomic analysis of bronchial brushings, biopsies and sputum cells was performed...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29643544/-bronchial-adenoid-cystic-carcinoma-masquerading-as-bronchial-asthma-a-case-report
#8
M Lu, M Wang, X Zhu, Y H Chen, W Z Yao
Here we reported a case of bronchial adenoid cystic carcinoma from Peking University Third Hospital. A 40-year-old female presented with dry cough for 1 year and nocturnal paroxysmal attacks of wheezing for 4 months. She was a non-smoker, and did not have past histories of asthma or allergy. On physical examination, no stridor, wheezing and cyanosis were present and the general appearance was good. The results of the laboratory analysis, including blood eosinophils count, immunoglobulin E level and chest X-ray were normal...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29627118/alveolar-and-bronchial-nitric-oxide-in-chronic-obstructive-pulmonary-disease-and-asthma-copd-overlap
#9
Bernardino Alcázar-Navarrete, Francisca Castellano Miñán, Pablo Santiago Díaz, Oliveiro Ruiz Rodríguez, Pedro J Romero Palacios
INTRODUCTION: Exhaled nitric oxide (FENO ) measurements differentiate COPD phenotypes from asthma-COPD overlap (ACO). To date, no study has been conducted to determine whether alveolar and bronchial components differ in this group of patients. METHODS: This was an observational cross-sectional study recruiting ambulatory COPD patients. FENO was measured, differentiating alveolar (CANO ) from bronchial (JawNO ) components using a multiple-flow technique. CANO and JawNO values were compared between eosinophilic COPD patients (defined as ≥ 300 eosinophils/μL in peripheral blood test, or ≥ 2% eosinophils or ≥ 3% eosinophils), and a linear regression analysis was performed to determine clinical and biological variables related to these measurements...
April 4, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29627041/obesity-and-asthma
#10
REVIEW
Ubong Peters, Anne E Dixon, Erick Forno
Obesity is a vast public health problem and both a major risk factor and disease modifier for asthma in children and adults. Obese subjects have increased asthma risk, and obese asthmatic patients have more symptoms, more frequent and severe exacerbations, reduced response to several asthma medications, and decreased quality of life. Obese asthma is a complex syndrome, including different phenotypes of disease that are just beginning to be understood. We examine the epidemiology and characteristics of this syndrome in children and adults, as well as the changes in lung function seen in each age group...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29617923/breastfeeding-and-childhood-wheeze-age-specific-analyses-and-longitudinal-wheezing-phenotypes-as-complimentary-approaches-to-the-analysis-of-cohort-data
#11
Maria A Quigley, Claire Carson, Yvonne Kelly
Systematic reviews suggest that breastfeeding is associated with a lower risk of asthma, although marked heterogeneity exists. Using UK Millennium Cohort Study data (n = 10,126 children born 2000-2001), we examined the association between breastfeeding duration and wheezing in the past year, first at each age-group separately (age 9 months, 3, 5, 7 and 11 years) and then as a longitudinal wheezing phenotype: 'early transient' (wheezing any time up to age 5 but not thereafter); 'late onset' (any time from age 7 but not beforehand); 'persistent' (any time up to age 5 and any time from age 7)...
April 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29617859/human-lung-epithelial-cells-support-human-metapneumovirus-persistence-by-overcoming-apoptosis
#12
Stefania Marsico, Francesca Caccuri, Pietro Mazzuca, Paola Apostoli, Sara Roversi, Giovanni Lorenzin, Alberto Zani, Simona Fiorentini, Cinzia Giagulli, Arnaldo Caruso
Human metapneumovirus (hMPV) has been identified as a major cause of lower respiratory tract infection in children. Epidemiological and molecular evidence has highlighted an association between severe childhood respiratory viral infection and chronic lung diseases, such as asthma and chronic obstructive pulmonary disease. Currently, animal models have demonstrated the ability of hMPV to persist in vivo suggesting a role of the virus in asthma development in children. However, mechanisms involved in hMPV persistence in the respiratory tract are not yet understood...
March 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29617009/correction-differentiation-of-quantitative-ct-imaging-phenotypes-in-asthma-versus-copd
#13
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000252.].
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29611776/last-station-in-the-eosinophilic-asthma-with-chronic-rhinosinusitis-and-or-nasal-polyposis-march-eosinophilic-asthma-with-radiological-findings-associated-with-blood-eosinophilia
#14
Insu Yılmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez
OBJECTIVE: Eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis (EA-CRS/NP) is a subphenotype of adult-onset eosinophilic asthma. Blood eosinophil levels are shown to be highly elevated in patients with EA-CRS/NP and have potential for tissue infiltration. We aimed to demonstrate the clinical features of the patients who have a blood eosinophil level above 10% and have thorax computed tomography findings due to blood eosinophilia. METHODS: Patients who were followed up in our clinic between 2012 and 2017 were retrospectively evaluated...
April 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#15
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas Covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29609049/type-2-biomarkers-and-prediction-of-future-exacerbations-and-lung-function-decline-in-adult-asthma
#16
Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
BACKGROUND: Type 2 biomarkers that predict both likelihood of future severe exacerbations and response to monoclonal antibody therapy in asthma, would be useful clinically in identifying patients both at greater risk of hospitalization, and most likely to benefit from monoclonal antibody therapy. OBJECTIVE: To describe the association between the Type 2 biomarkers, blood eosinophils, FeNO, serum periostin, serum IgE and time to severe exacerbation in a broad asthma population...
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29606855/benralizumab-in-the-treatment-of-severe-asthma-design-development-and-potential-place-in-therapy
#17
REVIEW
Corrado Pelaia, Alessandro Vatrella, Andrea Bruni, Rosa Terracciano, Girolamo Pelaia
Asthma is a widespread and heterogeneous inflammatory disease of the airways, which is characterized by several different phenotypes and endotypes. In particular, eosinophilic airway inflammation is a common pathologic trait of both allergic and nonallergic asthma. The key cytokine responsible for maturation, activation, recruitment, and survival of eosinophils is interleukin (IL)-5, which is mainly produced by T helper 2 (Th2) lymphocytes and group 2 innate lymphoid cells. Therefore, for uncontrolled patients with severe eosinophilic asthma, who are not fully responsive to corticosteroids, IL-5 represents a very important molecular target for add-on biological therapies...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29604118/what-does-lung-function-tell-us-about-respiratory-multimorbidity-in-childhood-and-early-adulthood-results-from-the-mas-birth-cohort-study
#18
Dirk Schramm, Marvin Reuter, Linus B Grabenhenrich, Antje Schuster, Christiane Lex, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Renate L Bergmann, Karl E Bergmann, Ulrich Wahn, Thomas Keil, Susanne Lau
BACKGROUND: Interaction of respiratory multimorbidity and lung function has not been examined in longitudinal population studies. We aimed to assess the association of multimorbidity of asthma and rhinitis with lung function and bronchial hyperresponsiveness in comparison to single and no allergies from early school age to young adulthood. METHODS: In 1990, the Multicenter Allergy Study birth cohort recruited 1314 newborns from 5 German cities. At 7, 13 and 20 years, we performed lung function and bronchial challenge tests...
March 31, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29602169/allergic-phenotype-of-chronic-rhinosinusitis-based-on-radiologic-pattern-of-disease
#19
Aneeza W Hamizan, Patricia A Loftus, Raquel Alvarado, Jacqueline Ho, Larry Kalish, Raymond Sacks, John M DelGaudio, Richard J Harvey
OBJECTIVES/HYPOTHESIS: Polypoid edema of the middle turbinate is a marker of inhalant allergy. Extensive edematous changes may result in limited central nasal and sinus disease, which has been called central compartment atopic disease (CCAD). Radiologically, this is seen as soft tissue thickening in the central portion of the sinonasal cavity with or without paranasal sinus involvement. When the sinuses are involved, the soft tissue thickening spares the sinus roof or lateral wall (centrally limited)...
March 30, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29601613/an-acne-survey-from-the-world-s-largest-annual-gathering-of-twins
#20
Amanda Suggs, Mathew Loesch, Harib Ezaldein, Luisa Christensen, Danyelle Dawes, Elma Baron
IMPORTANCE: Surveying identical twins allows us to qualitatively separate genetic and environmental factors that may contribute to acne severity. OBJECTIVE: To study a cohort of identical and fraternal twins to identify environmental factors that may influence acne severity. DESIGN, SETTING, PARTICIPANTS: A survey was administered to 139 identical and fraternal twin multiples (279 subjects) at the Annual Twins Day Festival in Twinsburg, Ohio on August 6-7, 2016...
April 1, 2018: Journal of Drugs in Dermatology: JDD
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