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https://www.readbyqxmd.com/read/29044001/vitrectomy-combined-with-intracular-drug-injection-on-treatment-of-endophthalmitis
#1
Lijuan Wei, Jinsong Zhang, Lixiao Zhou
This paper aimed to evaluate the clinical application value of vitrectomy combined with intraocular drug injection on treatment of severe endophthalmitis. Retrospective analyzed the 28 eyes for the 28 cases of patients suffering severe endophthalmitis, and with treatment of pars plana vitrectomy combined with intraocular drug injection, and foreign matter removal surgery. This study also analyzed the whole body and local application of antibiotics data, and clinical data of corticosteroid drug treatment. This study had followed up 6 to 12 months, 28 intraocular infected eyes of the 28 cases all had got controlled...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29041020/-pilot-study-on-the-effects-and-benefits-of-autologous-fat-grafting-in-osteoarthritis-of-the-cmc-1-joint-compared-to-intraarticular-cortisone-injection-results-after-3-months
#2
Elisabeth Maria Haas, Elias Volkmer, Riccardo E Giunta
Background/Aim Preliminary data suggest that an intraarticular autologous fat transplant may be useful in osteoarthritis (OA) of the CMC-1 joint. This prospective, non-randomised pilot study investigates this new method with a view to clinical outcomes compared with intraarticular corticosteroid injection. Patients and Methods 17 women and 7 men with an average age of 63.3 (47-75) years with symptomatic OA were included in the study. In 12 patients, a radiologically guided injection of 1-1.5 ml of adipose tissue was carried out after transumbilical liposuction of 10 ml of abdominal fat...
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29040008/analysis-of-the-clinical-profile-and-management-of-inflammatory-choriodal-neovascular-membranes-in-uveitic-eyes-a-study-from-a-tertiary-referral-center
#3
Sudha Ganesh, Arshee Ahmed, Jyotirmay Biswas
PURPOSE: To analyze clinical profile and management of inflammatory choroidal neovascularization (CNV) seen at a referral uveitis clinic. METHODS: Records of patients with uveitis and inflammatory CNV from January 1989 to April 2012 were retrieved and the data was analyzed. RESULTS: Forty-nine eyes of 43 patients were included. Mean age at presentation was 35.81 years. Eighteen eyes (36.7%) had infective etiology and 31 eyes (63.2%) had non-infective etiology...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29037195/comparison-between-xcelligence-biosensor-technology-and-conventional-cell-culture-system-for-real-time-monitoring-human-tenocytes-proliferation-and-drugs-cytotoxicity-screening
#4
Chih-Hao Chiu, Kin Fong Lei, Wen-Ling Yeh, Poyu Chen, Yi-Sheng Chan, Kuo-Yao Hsu, Alvin Chao-Yu Chen
BACKGROUND: Local injections of anesthetics, NSAIDs, and corticosteroids for tendinopathies are empirically used. They are believed to have some cytotoxicity toward tenocytes. The maximal efficacy dosages of local injections should be determined. A commercial 2D microfluidic xCELLigence system had been developed to detect real-time cellular proliferation and their responses to different stimuli and had been used in several biomedical applications. The purpose of this study is to determine if human tenocytes can successfully proliferate inside xCELLigence system and the result has high correlation with conventional cell culture methods in the same condition...
October 16, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#5
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/29030775/improvement-in-pregnancy-outcomes-in-couples-with-immunologically-male-infertility-undergoing-prednisolone-treatment-and-conventional-in-vitro-fertilization-preceded-by-sperm-penetration-assay-a-randomized-controlled-trial
#6
Ahmed M Taiyeb, Mundhir T Ridha-Albarzanchi, Shereen M Taiyeb, Zuhair A Kanan, Shahla K Alatrakchi, Michael E Kjelland, Saeeda A Muhsen-Alanssari
PURPOSE: Anti-sperm antibodies (ASA) in men impair not only sperm motility but also fertilization and conception. However, utilization of corticosteroids to suppress ASA has shown variable pregnancy outcomes. This controversy is also extended to include the usefulness of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in treatments of men with ASA. This study was therefore designed to define factors contributing to these inconsistent results. METHODS: Infertile men having ASA (n = 241) were randomly assigned for treatment with or without prednisolone for three cycles each of 21 days of their partner's menstrual cycles...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29027570/are-we-right-to-consider-mesenchymal-stem-cells-to-be-a-new-perspective-for-patients-with-juvenile-idiopathic-arthritis
#7
REVIEW
Krzysztof Orczyk, Elzbieta Smolewska
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. MSCs can modulate inflammation via mechanisms of both adaptive and innate immune response. They are able to inhibit T and B cell proliferation, promote regulatory T cells, suppress the maturation of dendritic cells, stimulate macrophage differentiation into M2 phenotype and reduce effectiveness of natural killer cells...
October 13, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29027006/comparative-outcomes-of-combined-corticosteroid-with-low-volume-compared-to-high-volume-of-local-anesthetic-in-subacromial-injection-for-impingement-syndrome-systematic-review-and-meta-analysis-of-rcts
#8
Sermsak Sumanont, Manusak Boonard, Ekachot Peradhammanon, Alisara Arirachakaran, Pattanapong Suwankomonkul, Worawit Oungbumrungpan, Jatupon Kongtharvonskul
Subacromial impingement syndrome (SIS) is one of the most frequent pathologies of the shoulder, which may cause serious restriction of daily activities and lifestyle changes. Corticosteroid injection (CI) into the subacromial space is a palliative treatment option. Currently, there have been no studies that compare between the different volumes of CI injection. We have conducted a systematic review and meta-analysis to answer our specific study questions: Are high volume (< 5 ml) better than low volume (≥ 5 ml) of CI injection with respect to pain reduction? This systematic review was conducted according to the preferred reporting items for systematic reviews and meta-analyses guidelines...
October 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29026332/ultrasound-guided-methotrexate-injection-for-de-quervain-disease-of-the-wrist-what-lies-beyond-the-horizon
#9
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29024802/synovial-and-systemic-pharmacokinetics-of-triamcinolone-acetonide-following-intra-articular-injection-of-an-extended-release-microsphere-based-formulation-fx006-or-standard-crystalline-suspension-in-patients-with-knee-osteoarthritis
#10
Virginia B Kraus, Philip G Conaghan, Hessam A Aazami, Purvi Mehra, Alan J Kivitz, Joelle Lufkin, Jessica Hauben, James R Johnson, Neil Bodick
OBJECTIVE: Intra-articular (IA) corticosteroids relieve osteoarthritis (OA) pain, but rapid absorption into systemic circulation may limit efficacy and produce untoward effects. We compared the pharmacokinetics of IA triamcinolone acetonide (TA) delivered as an extended-release, microsphere-based formulation (FX006) vs a crystalline suspension (TAcs) in knee OA patients. METHOD: This Phase 2 open-label study sequentially enrolled 81 patients who received a single IA injection of FX006 (5 mL, 32mg delivered dose, N=63) or TAcs (1 mL, 40mg, N=18)...
October 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29022793/intralesional-excision-with-topical-intralesional-cryotherapy-improves-the-treatment-of-keloid-scarring-in-a-paediatric-patient
#11
D Reissis, T Tickunas, R A Agha, Avh Greig
Recurrent keloid scarring has a significant impact on quality of life. Management is complex, particularly for scars resistant to conventional treatments and in paediatric cases where radiotherapy is not a suitable adjunct to surgical excision. We present the case of a nine-year-old African Caribbean girl with multiple large and recurrent keloid scars on both ears and bilateral sensorineural deafness. Following repeated intralesional excisions, corticosteroid and botulinum toxin injections, she continued to experience rapid recurrence of her keloids, worsening pain and pruritus...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29020874/safety-of-corticosteroid-injection-for-carpal-tunnel-syndrome
#12
Emma Kaile, Jeremy D P Bland
The risks of corticosteroid injection for carpal tunnel syndrome, principally intraneural injection and tendon rupture, are known only from anecdotal reports. The literature does not allow an accurate estimate of their incidence or that of lesser side effects such as local pain. We have encountered only four serious complications in 9515 injections. We asked patients about possible side effects at routine follow-up, 6 weeks after 689 injections with 40 mg triamcinolone. Possible side effects were reported after 33% of injections...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29020496/clinical-outcomes-of-adjunctive-sustained-release-intravitreal-dexamethasone-implants-in-tuberculosis-associated-multifocal-serpigenoid-choroiditis
#13
Lubhani Jain, Krushna Gopal Panda, Soumyava Basu
PURPOSE: To analyze the safety and efficacy of sustained-release intravitreal dexamethasone implant (Ozurdex) in management of TB-associated multifocal serpiginoid choroiditis (MSC). METHODS: Retrospective review of TB-associated MSC patients, treated with anti-TB therapy (ATT) and adjunctive intravitreal Ozurdex. RESULTS: Nine eyes of six patients were included. Four patients required Ozurdex implant for progressive or new lesions following ATT and two for additional systemic contraindications to corticosteroids - hyperglycemia and uncontrolled hypertension, respectively...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29016932/systemic-effects-of-epidural-corticosteroid-injection
#14
Wade King, David C Miller, Clark C Smith
No abstract text is available yet for this article.
July 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28993766/therapeutic-potential-of-shark-anti-icosl-vnar-domains-is-exemplified-in-a-murine-model-of-autoimmune-non-infectious-uveitis
#15
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J Barelle, Andrew Porter
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS. Suppression of full T cell activation can be achieved by blocking this interaction and has been shown to be an effective means of ameliorating disease in models of autoimmunity and inflammation. In this study, we demonstrated the ability of a novel class of anti-ICOSL antigen-binding single domains derived from sharks (VNARs) to effectively reduce inflammation in a murine model of non-infectious uveitis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28988225/persistent-de-quervain-tenosynovitis-induced-by-somatotropin-treatment
#16
Ozan Volkan Yurdakul, Lütfiye Aytüre, Ebru Yilmaz Yalçinkaya
BACKGROUND: Growth hormone deficiency is a well-known clinical entity that is usually treated with somatotropin (growth hormone). Growth hormone has some frequent side effects such as intracranial hypertension, lymphedema and diabetes mellitus. CASE PRESENTATION: We report the case of a 14-year-old girl with a history of wrist pain and clumsiness. Magnetic resonance imaging revealed de Quervain tenosynovitis. The patient had a history of using growth hormones for 12 months...
October 9, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28984697/mixed-lichenoid-and-follicular-t-and-b-cell-lymphoid-reaction-to-red-tattoos-with-monoclonal-t-cells
#17
Hiba Zaaroura, Reuven Bergman
Pseudolymphomatous reactions have been described to occur in tattoos. Most cases have exhibited T-cell predominance and polyclonal T-cell receptor gene rearrangements. One case with monoclonal IgH gene rearrangements progressed into B-cell lymphoma. Lichenoid infiltrates are commonly described but lymphoid follicles much less frequently. We report a case with mixed lichenoid and follicular T- and B-cell reaction to red tattoos. The histopathology and the immunohistochemical studies were constant with a mixed T- and B-cell pseudolymphoma, the IgH gene rearrangement study was polyclonal, but the T-cell receptor gene rearrangement study was monoclonal...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28979900/comparison-of-the-effects-of-interleukin-1-on-equine-articular-cartilage-explants-and-cocultures-of-osteochondral-and-synovial-explants
#18
Christopher R Byron, Richard A Trahan
Osteoarthritis (OA) is a ubiquitous disease affecting many horses. The disease causes chronic pain and decreased performance for patients and great cost to owners for diagnosis and treatment. The most common treatments include systemic non-steroidal anti-inflammatory drugs and intra-articular injection of corticosteroids. There is excellent support for the palliative pain relief these treatments provide; however, they do not arrest progression and may in some instances hasten advancement of disease. Orthobiologic treatments have been investigated as potential OA treatments that may not only ameliorate pain but also prevent or reverse pathologic articular tissue changes...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28965100/evolution-of-pain-at-3-months-by-oral-resveratrol-in-knee-osteoarthritis-arthrol-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial
#19
Christelle Nguyen, Isabelle Boutron, Gabriel Baron, Emmanuel Coudeyre, Francis Berenbaum, Serge Poiraudeau, François Rannou
INTRODUCTION: Osteoarthritis (OA) pathophysiology is driven in part by joint inflammation. Resveratrol has in vitro anti-inflammatory properties. We aim to assess the efficacy of oral resveratrol for knee pain at 3 months in people with knee OA. METHODS AND ANALYSIS: We will conduct a randomised double-blind placebo-controlled trial. Overall, 164 individuals with knee OA fulfilling 1986 American College of Rheumatology criteria will be recruited in three tertiary care centres in France and randomised to receive oral resveratrol, 40 mg (two caplets) two times per day for 1 week, then 20 mg (one caplet) two times per day or a matching placebo for a total of 6 months...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28963634/intra-articular-methotrexate-versus-corticosteroid-injections-in-medium-sized-joints-of-rheumatoid-arthritis-patients-an-intervention-study
#20
Mohmad Attia Mortada, Shimaa Mustafa Abdelwhab, Mohmad H Elgawish
The effects of intra-articular methotrexate (I/A MTX) in knee synovitis in rheumatoid arthritis have been previously evaluated. I/A MTX has not been studied in other joints. Ultrasonography (US) has been little studied in monitoring the effect of I/A MTX. The aim of the study is to test the efficacy of I/A MTX in suppression of persistent synovitis in medium-sized joints (ankle, wrist, and elbow) in rheumatoid arthritis patients. Patients were divided into two groups: group 1 (methotrexate group): 56 patients in which 84 joints (32 ankles, 28 wrists, and 24 elbows) were injected intra-articularly by 10 mg of methotrexate in the targeted joint on a weekly basis for 8 weeks and group 2 (steroid group): 44 patients in which 70 joints (26 ankles, 24 wrists, and 20 elbows) were injected once by Triamcinolone acetonide 40 mg...
September 30, 2017: Clinical Rheumatology
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