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https://www.readbyqxmd.com/read/29933283/injectable-corticosteroids-in-sport
#1
Nathan P Olafsen, Stanley A Herring, John W Orchard
OBJECTIVE: To review the literature guiding all aspects of the use of injectable corticosteroids for painful musculoskeletal conditions, with a focus on the treatment of athletes. DATA SOURCES: An extensive search of the literature was completed including search terms of corticosteroid, steroid, athlete, and injection, among others. Additional articles were used after being identified from previously reviewed articles. MAIN RESULTS: Injections of corticosteroids for a variety of painful conditions of the extremities and the axial spine have been described...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29931169/association-of-vertigo-with-hearing-outcomes-in-patients-with-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#2
Huiqian Yu, Huawei Li
Importance: Sudden sensorineural hearing loss (SSHL) accompanied by vertigo may portend a negative prognosis in the hearing outcome. Objective: To investigate the association of vertigo with prognosis of hearing variables in SSHL. Data Sources: A literature search of eligible studies was performed in PubMed, Web of Science, and Embase from September 26, 1973, through September 26, 2017. Studies published in English were retrieved with no restrictions on the date of publication...
June 21, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29929016/intralesional-steroid-injections-for-recurrent-vaginal-strictures
#3
Jessica Shim, Maggie Dwiggins, Veronica Gomez-Lobo
BACKGROUND: Postoperative complications after transverse vaginal septum excision include stricture formation. The purpose of this report is to describe use of intralesional corticosteroid injections for vaginal strictures. CASE: A 32-year-old gravida-0 with history of transverse vaginal septum and recurrent strictures presented for follow-up of chronic pelvic pain. After her fourth septum revision, the patient underwent a total of seven triamcinolone injections at the septum tissue...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29928204/bullous-pemphigoid-associated-with-adalimumab-therapy-in-a-patient-with-ulcerative-colitis
#4
Sebastian Hoffmann, Mark Berneburg, Stephan Schreml
Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Other autoimmune diseases, such as lupus erythematosus, are also known to occur under TNF inhibition. Here, we report on an 81-year-old patient who received adalimumab for ulcerative colitis and subsequently developed BP. Other causes of BP (tumors, other drugs, viral or toxoplasma infections) were excluded...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29922466/hidradenitis-suppurativa-with-sapho-syndrome-maintained-effectively-with-adalimumab-methotrexate-and-intralesional-corticosteroid-injections
#5
Erika L Crowley, Ashley O'Toole, Melinda J Gooderham
Introduction: Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare. Methods/Results: This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29911137/arthroscopic-partial-meniscectomy-for-painful-degenerative-meniscal-tears-in-the-presence-of-knee-osteoarthritis-in-patients-older-than-50-years-of-age-predictors-of-an-early-1-to-5-years-total-knee-replacement
#6
E Carlos Rodriguez-Merchan, Jose A Garcia-Ramos, Norma G Padilla-Eguiluz, Enrique Gomez-Barrena
Background: The role of arthroscopic partial meniscectomy (APM) for painful degenerative meniscal tears (PDMT) is currently controversial.To define the rate of early (1 to 5 years) conversion to total knee replacement (TKR) and their predictors after APM for PDMT in patients with knee osteoarthritis and more than 50 years of age. Methods: Retrospective cohort study of patients more than 50 years of age with the diagnosis of PDMT, treated by means of APM. Patients were classified in two groups: Patients that required an early (between 1 and 5 years after APM) TKR (TKR group) after its failure and patients that did not require a TKR (non-TKR group)...
May 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29909960/etiology-and-treatment-outcomes-of-persistent-postoperative-inflammation-in-primary-resident-performed-cataract-surgeries-at-a-large-tertiary-care-public-hospital
#7
Saagar N Patel, Shazia F Ali, Cameron Clarke, Jonathan Kim, Michael Murri, Marie Tuft, Christina Y Weng, Zaina Al-Mohtaseb
PURPOSE: To determine the risk factors, intraoperative and postoperative complications, therapeutic interventions, and visual outcomes for persistent postoperative inflammation in primary resident-performed cataract surgeries. SETTING: Ben Taub General Hospital, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Primary resident-performed cataract surgeries from January 2012 to June 2015 were analyzed for persistent postoperative inflammation, defined as persistent anterior chamber inflammatory reaction after a standard 1-month topical corticosteroid and nonsteroidal antiinflammatory drug (NSAID) drops taper...
June 14, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#8
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29909445/centers-for-disease-control-and-prevention-2017-guidelines-for-prevention-of-surgical-site-infections-review-and-relevant-recommendations
#9
REVIEW
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29907665/longterm-effectiveness-of-intraarticular-injections-on-patient-reported-symptoms-in-knee-osteoarthritis
#10
Shao-Hsien Liu, Catherine E Dubé, Charles B Eaton, Jeffrey B Driban, Timothy E McAlindon, Kate L Lapane
OBJECTIVE: We examined the longterm effectiveness of corticosteroid or hyaluronic acid injections in relieving symptoms among persons with knee osteoarthritis (OA). METHODS: Using Osteoarthritis Initiative data, a new-user design was applied to identify participants initiating corticosteroid or hyaluronic acid injections (n = 412). Knee symptoms (pain, stiffness, function) were measured using The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29906555/injectable-liquid-polymers-extend-the-delivery-of-corticosteroids-for-the-treatment-of-osteoarthritis
#11
Edgardo Rivera-Delgado, Ashley Djuhadi, Chaitanya Danda, Jonathan Kenyon, João Maia, Arnold I Caplan, Horst A von Recum
Drug delivery strategies generally use inert materials, such as high molecular weight polymers, to encapsulate and control the release rate of therapeutic drugs. Diffusion governs release and depends on the ease of permeation of the polymer alongside the device thickness. Yet in applications such as osteoarthritis, the physiological constraints and limited intra-articular joint space prevent the use of large, solid drug delivery implants. Other investigators have explored the use of micro- and nanoparticle drug delivery systems...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29906501/repurposing-drugs-as-inhaled-therapies-in-asthma
#12
Sandra D Anderson
For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. After 1945, isoprenaline, a non-selective beta agonist, became available for oral use but it was most widely used by inhalation. Isoprenaline was short-acting with unwanted cardiac effects...
June 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29900526/transplacental-versus-direct-fetal-corticosteroid-treatment-for-accelerating-fetal-lung-maturation-where-there-is-a-risk-of-preterm-birth
#13
REVIEW
Debby P Utama, Caroline A Crowther
BACKGROUND: Despite major advances in medical technology, the incidence of preterm birth remains high. The use of antenatal corticosteroid administered transplacentally, by intramuscular injection to women at risk of preterm birth, has reduced the incidence of respiratory distress syndrome and increased the survival rates of preterm infants. However, this intervention also comes with its own risks and side effects. Animal studies and early studies in pregnant women at risk of preterm birth have reported the use of an alternative route of administration, by direct intramuscular injection of corticosteroid into the fetus under ultrasound guidance, in an attempt to minimise the side-effect profile...
June 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29891265/cost-effective-management-of-stenosing-tenosynovitis
#14
Andrea Halim, Andrew D Sobel, Adam E M Eltorai, Kaveh P Mansuripur, Arnold-Peter C Weiss
PURPOSE: Stenosing tenosynovitis (STS) is a common condition treated by hand surgeons. Limited evidence exists to support the nonsurgical management of STS. The purpose of this study was to prospectively evaluate a cohort of patients with STS, and to determine the strategy for treating patients with this condition that is most cost effective in terms of dollars reimbursed by payers. METHODS: Prospective data were collected on patients diagnosed with STS between March 2014 and September 2014...
June 8, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29886113/comparison-of-intralesional-verapamil-versus-intralesional-corticosteroids-in-treatment-of-keloids-and-hypertrophic-scars-a-randomized-controlled-trial
#15
Robabeh Abedini, Pardis Sasani, Hamid Reza Mahmoudi, Maryam Nasimi, Amir Teymourpour, Zahra Shadlou
BACKGROUND: Keloids and hypertrophic scars are due to overgrowth of dermal collagen following trauma to the skin that usually cause major physical, psychological and cosmetic problems. METHODS: In this randomized controlled trial, with a paired design, 50 patients with 2 or more keloids were included. In the control group (50 lesions), intralesional triamcinolone acetonide (40mg/mL) was injected at three-week intervals for a total of 18weeks. In the other group (50 lesions), lesions were treated by verapamil (2...
June 6, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29886069/repurposing-of-gamma-interferon-via-inhalation-delivery
#16
Gerald C Smaldone
Pulmonary diseases frequently involve imbalances in immunity. The inability to control bacteria in tuberculosis is a failed response to a pathogen. Idiopathic pulmonary fibrosis (IPF), a progressive fibrotic lung disease, can lead to respiratory failure and death within 3 years of diagnosis. Chronic obstructive pulmonary disease (COPD) progresses until death and in recent years has been labeled an autoimmune disease. Proposed mechanistic pathways of pathophysiology involve uncontrolled healing governed by pro-fibrotic cytokines that are unresponsive to the standard anti-inflammatory agents (e...
June 7, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29883820/extensive-spinal-adhesive-arachnoiditis-after-extradural-spinal-infection-spinal-dura-mater-is-no-barrier-to-inflammation
#17
Theresa Krätzig, Marc Dreimann, Klaus Christian Mende, Ingo Königs, Manfred Westphal, Sven Oliver Eicker
BACKGROUND: Spinal adhesive arachnoiditis (SAA) is an inflammatory process of the meninges. Cystic changes and cicatrisation may lead to neurological deficits and immobilization. Therapy is difficult and often unsatisfactory. We describe eight cases of extensive SAA following extradural spinal infection. METHODS: 238 patients with epidural abscess or osteomyelitis were treated at our institution between 2011 and 2018. We identified eight patients who developed extensive SAA on follow-up...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29883326/-methods-of-efficacy-assessment-of-the-knee-joint-radiosynoviorthesis-personal-experience
#18
Robert Zwolak, Maria Majdan
OBJECTIVE: Introduction: Radiosynoviorthesis (RS) is local method of treatment of remittent joint effusions among patients who obtained general improvement after disease modifying anti-rheumatic drugs therapy but one or a few joints stay resistant to this treatment and intraarticular corticosteroids injections. The aim: The attempt to identification methods of efficacy assessment of the 90yttrium knee joint RS. PATIENTS AND METHODS: Material and methods: The study group consisted of 43 patients with rheumatoid arthritis (RA) and 19 patients with inflammatory spondyloarthropaties (SPA) where 8 patients were treated for ankylosing spondylitis (AS), 4 for psoriatic arthritis (PsA) and 7 due to undifferentiated inflammatory spondyloarthropaties (USPA)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29883224/treatment-of-sarcoidosis-grading-the-evidence
#19
W Ennis James, Robert Baughman
Treatment of sarcoidosis recommendations are often based on clinical experience and expert opinion. However, there are an increasing number of studies which are providing evidence to support decisions regarding treatment. Areas covered: Several studies have identified factors associated with increased risk for organ failure or death ('danger'). There have been several studies focused on the role of treatment to improve quality of life for the patient. Sarcoidosis treatment often follows a progression, based on response...
June 18, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29875901/arthroscopic-synovectomy-for-the-treatment-of-stage-ii-to-iv-trapeziometacarpal-joint-arthritis
#20
Takeshi Ogawa, Toshikazu Tanaka, Shunsuke Asakawa, Masaki Tatsumura, Takeo Mammoto, Atsushi Hirano
Objective: As a minimal invasive surgery for the treatment of thumb carpometacarpal joint (trapeziometacarpal [TMC]) arthritis, we performed an arthroscopic synovectomy for Eaton stage II to IV arthritis. Patients and Methods: We included patients who were effectively treated with a corticosteroid injection, experienced recurrence of TMC pain, and had no major instability of the TMC. Surgery was performed in 17 female patients. Synovectomy was performed, when possible, using radiofrequency and a shaver. The mean follow-up period was 27...
May 2018: Journal of Rural Medicine: JRM
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