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Urine PCA 3

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https://www.readbyqxmd.com/read/29177945/removing-the-urinary-catheter-on-post-operative-day-2-after-robot-assisted-laparoscopic-radical-prostatectomy-a-feasibility-study-from-a-single-high-volume-referral-centre
#1
Aldo Brassetti, Flavia Proietti, Antonio Cardi, Antonio De Vico, Antonio Iannello, Alberto Pansadoro, Aldo Scapellato, Tommaso Riga, Paolo Emiliozzi, Gianluca D'Elia
The indwelling urinary catheter (UC) is a significant bother for men after radical prostatectomy (RP) and should be removed as soon as possible without jeopardizing the outcome. Our aim was to assess the feasibility and safety of its removal on postoperative day (POD) 2 after robot-assisted laparoscopic RP (RALP). A consecutive series of patients undergoing RALP for localized prostate cancer (PCa) were prospectively enrolled. Inclusion criteria were: no bladder-neck reconstruction, watertight urethrovesical anastomosis at 150 ml filling, ≤ 200 ml of intraoperative bleeding, ≤ 80 ml of fluid from the drain on POD 1, clear urine from the UC on POD 2...
November 25, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29175542/defining-a-cohort-of-men-who-may-not-require-repeat-prostate-biopsy-based-on-pca3-score-and-mri-the-dual-negative-effect
#2
Nathan Perlis, Thamir Al-Kasab, Ardalan Ahmad, Estee Goldberg, Kamel Fadak, Rashid Sayid, Antonio Finelli, Girish Kulkarni, Rob Hamilton, Alexandre Zlotta, Sangeet Ghai, Neil Fleshner
PURPOSE: Prostate Cancer (PCa) overdiagnosis and overtreatment is a concern for clinicians and policy makers. Multiparametric MRI (mpMRI) and the PCA3 urine test select for clinically significant cases. We explore how well the tests perform in combination for men with previous biopsies. MATERIALS AND METHODS: We collected clinicopathologic data from all patients with a PCA3 test from 2011 to June 2016 in accordance with ethics committee approval. This included patients on active surveillance (AS) for low-risk PCa and those without PCa with previous negative biopsies and suspicion of occult disease...
November 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29129398/genomic-markers-in-prostate-cancer-decision-making
#3
REVIEW
Vito Cucchiara, Matthew R Cooperberg, Marc Dall'Era, Daniel W Lin, Francesco Montorsi, Jack A Schalken, Christopher P Evans
CONTEXT: Although the widespread use of prostate-specific antigen (PSA) has led to an early detection of prostate cancer (PCa) and a reduction of metastatic disease at diagnosis, PSA remains one of the most controversial biomarkers due to its limited specificity. As part of emerging efforts to improve both detection and management decision making, a number of new genomic tools have recently been developed. OBJECTIVE: This review summarizes the ability of genomic biomarkers to recognize men at high risk of developing PCa, discriminate clinically insignificant and aggressive tumors, and facilitate the selection of therapies in patients with advanced disease...
November 9, 2017: European Urology
https://www.readbyqxmd.com/read/28992280/plasma-biomarkers-improve-prediction-of-diabetic-kidney-disease-in-adults-with-type-1-diabetes-over-a-12-year-follow-up-cacti-study
#4
Petter Bjornstad, Laura Pyle, David Z I Cherney, Richard J Johnson, Rachel Sippl, Randy Wong, Marian Rewers, Janet K Snell-Bergeon
Background: The objective of the study was to determine whether plasma biomarkers of kidney injury improve the prediction of diabetic kidney disease (DKD) in adults with type 1 diabetes (T1D) over a period of 12 years. Methods: Participants ( n  = 527, 53% females) in the Coronary Artery Calcification in T1D (CACTI) Study were examined during 2002-04, at a mean (± standard deviation) age of 39.6 ± 9.0 years with 24.8 years as the median duration of diabetes...
August 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28969674/development-and-validation-of-a-questionnaire-assessing-the-quality-of-life-impact-of-colour-blindness-cbqol
#5
John A Barry, Susan Mollan, Michael A Burdon, Michelle Jenkins, Alastair K Denniston
BACKGROUND: Congenital colour vision deficiency (CVD), commonly called 'colour blindness', affects around 8% of men and 0.4% of women. Although many aspects of health (e.g. change in colour of urine) and healthcare (e.g. coloured medication, colour-coded diagnostic tests), and modern life depend upon colour coding (e.g. graphs, maps, signals), the impact of colour blindness on everyday life is not generally considered a topic of importance. This study is the first to create and validate a questionnaire measuring the quality of life (QoL) impact of being colour blind...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28938580/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#6
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900493/a-multi-center-prospective-study-to-validate-an-algorithm-using-urine-and-plasma-biomarkers-for-predicting-gleason-%C3%A2-3-4-prostate-cancer-on-biopsy
#7
Maher Albitar, Wanlong Ma, Lars Lund, Babak Shahbaba, Edward Uchio, Soren Feddersen, Donald Moylan, Kirk Wojno, Neal Shore
Background: Unnecessary biopsies and overdiagnosis of prostate cancer (PCa) remain a serious healthcare problem. We have previously shown that urine- and plasma-based prostate-specific biomarkers when combined can predict high grade prostate cancer (PCa). To further validate this test, we performed a prospective multicenter study recruiting patients from community-based practices. Patients and Methods: Urine and plasma samples from 2528 men were tested prospectively. Results were correlated with biopsy findings, if a biopsy was performed as deemed necessary by the practicing urologist...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28853167/a-urinary-biomarker-based-risk-score-correlates-with-multiparametric-mri-for-prostate-cancer-detection
#8
Rianne J Hendriks, Marloes M G van der Leest, Siebren Dijkstra, Jelle O Barentsz, Wim Van Criekinge, Christina A Hulsbergen-van de Kaa, Jack A Schalken, Peter F A Mulders, Inge M van Oort
BACKGROUND: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection. METHODS: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies...
October 2017: Prostate
https://www.readbyqxmd.com/read/28783586/dynamic-surface-enhanced-raman-spectroscopy-and-chemometric-methods-for-fast-detection-and-intelligent-identification-of-methamphetamine-and-3-4-methylenedioxy-methamphetamine-in-human-urine
#9
Shizhuang Weng, Ronglu Dong, Zede Zhu, Dongyan Zhang, Jinling Zhao, Linsheng Huang, Dong Liang
Conventional Surface-Enhanced Raman Spectroscopy (SERS) for fast detection of drugs in urine on the portable Raman spectrometer remains challenges because of low sensitivity and unreliable Raman signal, and spectra process with manual intervention. Here, we develop a novel detection method of drugs in urine using chemometric methods and dynamic SERS (D-SERS) with mPEG-SH coated gold nanorods (GNRs). D-SERS combined with the uniform GNRs can obtain giant enhancement, and the signal is also of high reproducibility...
August 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28730787/association-of-ferritin-with-prostate-cancer
#10
Qiang Su, Ting Lei, Man Zhang
PURPOSE: Prostate specific antigen (PSA) has been widely used as the unique serum biomarker for the diagnosis and/ or pre-diagnosis of prostate cancer (PCa). However, the diagnostic value of PSA is a subject of ongoing debate owing to its lack of specificity, especially when the PSA level is moderately increased (e.g., 4-10 ng/ml). Thus, we suggest the need for identification of a new biomarker to discriminate PCa cases from benign prostatic hyperplasia (BPH) and normal controls (N). METHODS: Urine or tissue samples of PCa patients, BPH patients, and normal controls were systematically collected...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28717416/feasibility-of-urinary-extracellular-vesicle-proteome-profiling-using-a-robust-and-simple-clinically-applicable-isolation-method
#11
Irene V Bijnsdorp, Olga Maxouri, Aarzo Kardar, Tim Schelfhorst, Sander R Piersma, Thang V Pham, Andre Vis, R Jeroen van Moorselaar, Connie R Jimenez
Extracellular vesicles (EVs) secreted by prostate cancer (PCa) cells contain specific biomarkers and can be isolated from urine. Collection of urine is not invasive, and therefore urinary EVs represent a liquid biopsy for diagnostic and prognostic testing for PCa. In this study, we optimised urinary EV isolation using a method based on heat shock proteins and compared it to gold-standard ultracentrifugation. The urinary EV isolation protocol using the Vn96-peptide is easier, time convenient (≈1.5 h) and no special equipment is needed, in contrast to ultracentrifugation protocol (>3...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28704754/metabolomics-study-of-cadmium-induced-diabetic-nephropathy-and-protective-effect-of-caffeic-acid-phenethyl-ester-using-uplc-q-tof-ms-combined-with-pattern-recognition
#12
Pin Gong, Xiangna Chang, Xuefeng Chen, Xiaohuan Bai, He Wen, Sihui Pi, Wenjuan Yang, Lan Wang, Fuxin Chen
Diabetic nephropathy (DN) is the most severe complication of diabetes and multiple factors are involved in the pathogenesis of DN. Among them, cadmium (Cd) acts as a risk factor inducing the occurrence of DN. The present study focused on investigating the protective role of caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, against Cd-induced DN in mice based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS)and pattern recognition...
June 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28495148/analysis-of-urinary-psa-glycosylation-is-not-indicative-of-high-risk-prostate-cancer
#13
Sílvia Barrabés, Esther Llop, Montserrat Ferrer-Batallé, Manel Ramírez, Rosa N Aleixandre, Antoinette S Perry, Rafael de Llorens, Rosa Peracaula
The levels of core fucosylation and α2,3-linked sialic acid in serum Prostate Specific Antigen (PSA), using the lectins Pholiota squarrosa lectin (PhoSL) and Sambucus nigra agglutinin (SNA), can discriminate between Benign Prostatic Hyperplasia (BPH) and indolent prostate cancer (PCa) from aggressive PCa. In the present work we evaluated whether these glycosylation determinants could also be altered in urinary PSA obtained after digital rectal examination (DRE) and could also be useful for diagnosis determinations...
July 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28489592/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#14
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394524/-x-ray-guided-endovascular-surgery-in-patients-with-benign-prostatic-hyperplasia-and-prostate-cancer
#15
A I Neimark, M A Tachalov, B A Neimark, D V Torbik, D D Arzamastsev
AIM: To evaluate the efficacy and safety of superselective embolization and chemoembolization of the prostatic artery as an independent method of treating prostate cancer and BPH. MATERIALS AND METHODS: From 2004 to 2015, 116 patients with BPH (mean age 73.2+/-5.2 years) underwent prostatic artery embolization. Mean prostate volume ranged from 55 to 296 cc3. From 2011 to 2015, 37 patients with prostate cancer (mean age 72.3+/-2.06 years) were treated with X-ray-guided endovascular chemoembolization...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28380027/evaluation-of-a-short-rna-within-prostate-cancer-gene-3-in-the-predictive-role-for-future-cancer-using-non-malignant-prostate-biopsies
#16
Karl H Pang, Derek J Rosario, Susan L Morgan, James W F Catto
BACKGROUND: Prostate Cancer 3 (PCA3) is a long non-coding RNA (ncRNA) upregulated in prostate cancer (PCa). We recently identified a short ncRNA expressed from intron 1 of PCA3. Here we test the ability of this ncRNA to predict the presence of cancer in men with a biopsy without PCa. METHODS: We selected men whose initial biopsy did not identify PCa and selected matched cohorts whose subsequent biopsies revealed PCa or benign tissue. We extracted RNA from the initial biopsy and measured PCA3-shRNA2, PCA3 and PSA (qRT-PCR)...
2017: PloS One
https://www.readbyqxmd.com/read/28340793/a-novel-quartz-crystal-microbalance-sensor-array-based-on-molecular-imprinted-polymers-for-simultaneous-detection-of-clenbuterol-and-its-metabolites
#17
Fan Feng, Jianwu Zheng, Peng Qin, Tao Han, Dayun Zhao
For the rapid and robust detection of both parent clenbuterol (CLB) and its metabolites in swine urine samples, a novel quartz crystal microbalance (QCM) sensor array for CLB detection based on molecularly imprinted polymers (MIPs) was developed in this investigation. At first, clenbuterol and the structural analogs of its metabolites, 4-Aminohippuric acid (AHA) and 4-hydroxymandelic acid (HMA), were chosen as molecular templates. Through computational molecular modeling, the optimum ratio between the functional monomer and molecular template was selected...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28212119/the-role-of-prostate-cancer-biomarkers-in-undiagnosed-men
#18
Hasan Dani, Stacy Loeb
PURPOSE OF REVIEW: This article intends to review biomarkers derived from blood, urine, and tissue that can aid in the diagnosis of prostate cancer (PCa). RECENT FINDINGS: PCa screening requires tools that complement prostate-specific antigen (PSA) with a higher specificity for clinically significant disease. Novel blood biomarkers, such as the Prostate Health Index (phi) and 4Kscore, utilize isoforms of PSA to more accurately predict high-grade PCa than traditional tools such as PSA and the percentage free-to-total PSA...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28009970/combined-serum-and-eps-urine-proteomic-analysis-using-itraq-technology-for-discovery-of-potential-prostate-cancer-biomarkers
#19
Mo Zhang, Lizhu Chen, Zhengwei Yuan, Zeyu Yang, Yue Li, Liping Shan, Bo Yin, Xiang Fei, Jianing Miao, Yongsheng Song
Prostate cancer (PCa) is one of the most common malignant tumors and a major cause of cancer-related death for men worldwide. The aim of our study was to identify potential non-invasive serum and expressed prostatic secretion (EPS)-urine biomarkers for accurate diagnosis of PCa. Here, we performed a combined isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis to compare protein profiles using pooled serum and EPS-urine samples from 4 groups of patients: benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN), localized PCa and metastatic PCa...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27987392/urinary-metabolic-profiling-of-cisplatin-nephrotoxicity-and-nephroprotective-effects-of-orthosiphon-stamineus-leaves-elucidated-by-1-h-nmr-spectroscopy
#20
Raghunath Pariyani, Intan Safinar Ismail, Amalina Azam, Alfi Khatib, Faridah Abas, Khozirah Shaari, Hazilawati Hamza
Orthosiphon stamineus (OS) is a popular medicinal herb used in traditional Chinese medicine as a diuretic agent and for renal system disorders. This study employed (1)H NMR based metabolomics approach to investigate the possible protective activity of OS in cisplatin induced nephrotoxicity owing to its diuretic and antioxidant activities. Aqueous (OSAE) and 50% aqueous ethanolic (OSFE) extracts of OS leaves were orally administered at 400mg/kg BW doses to rats which were then intraperitoneally injected with cisplatin at 5mg/kg BW dose...
February 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
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