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Urine PCA 3

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https://www.readbyqxmd.com/read/29671424/a-fluorescent-probe-based-on-a-tb-3-cu-2-co-functionalized-mof-for-urinary-sarcosine-detection
#1
Na-Na Sun, Bing Yan
A novel luminescent probe based on a Tb3+/Cu2+ heterometallic metal-organic framework (MOF) was first designed for beamed monitoring of urinary sarcosine, a differential metabolite that can indicate the progression of prostate cancer (PCa). The fluorescent probe presented high selectivity towards sarcosine in urine. It also displayed good sensitivity with a comparatively low detection limit and a fast response to sarcosine within 5 min. Moreover, such high selectivity and sensitivity towards sarcosine is not subject to interference from other coexisting species in urine...
April 19, 2018: Analyst
https://www.readbyqxmd.com/read/29608440/serum-and-urine-toxicometabolomics-following-gentamicin-induced-nephrotoxicity-in-male-sprague-dawley-rats
#2
Sung Ha Ryu, Ji Won Kim, Dahye Yoon, Suhkmann Kim, Kyu-Bong Kim
Gentamicin (GM) is an aminoglycoside antibiotic used in treatment of various types of bacterial infections, but the major adverse effect is drug-induced nephrotoxicity. This study aimed to determine biomarkers that might predict nephrotoxicity initiated by GM using serum or urinary proton nuclear magnetic resonance (1 H NMR) spectral data in male Sprague-Dawley rats. GM (0, 30, or 300 mg/kg/d) was intraperitoneally administered for 3 consecutive days. Animals were sacrificed 2 d (D2) or 8 d (D8) after last administration of GM in order to perform analysis of serum biochemistries and histopathologic examination...
April 2, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29547000/combination-of-prostate-cancer-antigen-3-and-prostate-specific-antigen-improves-diagnostic-accuracy-in-men-at-risk-of-prostate-cancer
#3
Liyun Cao, Chi Hyun Lee, Jing Ning, Beverly C Handy, Elizabeth A Wagar, Qing H Meng
CONTEXT: - Prostate cancer antigen 3 (PCA3) is a noncoding RNA that is highly overexpressed in prostate cancer (PCa) tissue and excreted in urine in patients with PCa. OBJECTIVE: - To assess the clinical utility of urinary PCA3 in men at risk of PCa. DESIGN: - We retrospectively reviewed a cohort of 271 men (median age, 63 years) with elevated prostate-specific antigen (PSA), and/or strong family history, and/or abnormal digital rectal examination findings...
March 16, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29502397/an-in-depth-glycosylation-assay-for-urinary-prostate-specific-antigen
#4
Guinevere Stevina Margaretha Kammeijer, Jan Nouta, Jean de la Rosette, Theo M de Reijke, Manfred Wuhrer
The concentration of prostate specific antigen (PSA) in serum is used as an early detection method of prostate cancer (PCa) showing, however, low sensitivity, specificity and a poor predictive value. Initial studies suggested the glycosylation of PSA to be a promising marker for a more specific yet non-invasive PCa diagnosis. Recent studies on the molecular features of PSA glycosylation (such as antenna modification and core fucosylation) were not successful in demonstrating its potential for an improved PCa diagnosis, probably due to the lack of analytical sensitivity and specificity of the applied assays...
March 4, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29453090/evaluating-effects-of-prenatal-exposure-to-phthalate-mixtures-on-birth-weight-a-comparison-of-three-statistical-approaches
#5
Yu-Han Chiu, Andrea Bellavia, Tamarra James-Todd, Katharine F Correia, Linda Valeri, Carmen Messerlian, Jennifer B Ford, Lidia Mínguez-Alarcón, Antonia M Calafat, Russ Hauser, Paige L Williams
OBJECTIVES: We applied three statistical approaches for evaluating associations between prenatal urinary concentrations of a mixture of phthalate metabolites and birth weight. METHODS: We included 300 women who provided 732 urine samples during pregnancy and delivered a singleton infant. We measured urinary concentrations of metabolites of di(2-ethylhexyl)-phthalate, di-isobutyl-, di-n-butyl-, butylbenzyl-, and diethyl phthalates. We applied 1) linear regressions; 2) classification methods [principal component analysis (PCA) and structural equation models (SEM)]; and 3) Bayesian kernel machine regression (BKMR), to evaluate associations between phthalate metabolite mixtures and birth weight adjusting for potential confounders...
February 13, 2018: Environment International
https://www.readbyqxmd.com/read/29395956/furan-and-p-xylene-as-candidate-biomarkers-for-prostate-cancer
#6
Antonio Jiménez-Pacheco, María Salinero-Bachiller, María C Iribar, Alfonso López-Luque, José L Miján-Ortiz, Jose M Peinado
BACKGROUND: Prostate cancer (PCa) is the most frequently diagnosed noncutaneous malignant tumor among males in the Western world. Prostate-specific antigen has been considered the most important biomarker for PCa detection; however, it lacks specificity, leading to the search for alternative biomarkers. Volatile organic compounds (VOCs) are released during cell metabolism and can be found in exhaled breath, urine, and other fluids. VOCs have been used in the diagnosis of lung, breast, ovarian, and colorectal cancers, among others...
January 21, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29315679/prostatectomy-based-validation-of-combined-urine-and-plasma-test-for-predicting-high-grade-prostate-cancer
#7
Maher Albitar, Wanlong Ma, Lars Lund, Babak Shahbaba, Edward Uchio, Søren Feddersen, Donald Moylan, Kirk Wojno, Neal Shore
BACKGROUND: Distinguishing between low- and high-grade prostate cancers (PCa) is important, but biopsy may underestimate the actual grade of cancer. We have previously shown that urine/plasma-based prostate-specific biomarkers can predict high grade PCa. Our objective was to determine the accuracy of a test using cell-free RNA levels of biomarkers in predicting prostatectomy results. METHODS: This multicenter community-based prospective study was conducted using urine/blood samples collected from 306 patients...
March 2018: Prostate
https://www.readbyqxmd.com/read/29291407/urine-volatile-organic-compounds-as-biomarkers-for-minimal-change-type-nephrotic-syndrome
#8
Desheng Liu, Nana Zhao, Mingao Wang, Xin Pi, Yue Feng, Yue Wang, Hongshuang Tong, Lin Zhu, Changsong Wang, Enyou Li
Urinary volatile organic compounds (VOCs) profiling has recently received considerable attention because it can be obtained noninvasively and conveniently while it can be successfully used in a variety of diseases and can provide unique biomarkers. The aim of current study was to investigate potential biomarkers between minimal change type nephrotic syndrome (MCNS) and normal. Urinary samples were collected from 38 minimal change type nephrotic syndrome patients and 15 healthy controls. Solid phase microextraction (SPME) and chromatography- mass spectrometry (GC-MS) were used to analysis the urinary metabolites...
January 29, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29177945/removing-the-urinary-catheter-on-post-operative-day-2-after-robot-assisted-laparoscopic-radical-prostatectomy-a-feasibility-study-from-a-single-high-volume-referral-centre
#9
Aldo Brassetti, Flavia Proietti, Antonio Cardi, Antonio De Vico, Antonio Iannello, Alberto Pansadoro, Aldo Scapellato, Tommaso Riga, Paolo Emiliozzi, Gianluca D'Elia
The indwelling urinary catheter (UC) is a significant bother for men after radical prostatectomy (RP) and should be removed as soon as possible without jeopardizing the outcome. Our aim was to assess the feasibility and safety of its removal on postoperative day (POD) 2 after robot-assisted laparoscopic RP (RALP). A consecutive series of patients undergoing RALP for localized prostate cancer (PCa) were prospectively enrolled. Inclusion criteria were: no bladder-neck reconstruction, watertight urethrovesical anastomosis at 150 ml filling, ≤ 200 ml of intraoperative bleeding, ≤ 80 ml of fluid from the drain on POD 1, clear urine from the UC on POD 2...
November 25, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29175542/defining-a-cohort-that-may-not-require-repeat-prostate-biopsy-based-on-pca3-score-and-magnetic-resonance-imaging-the-dual-negative-effect
#10
Nathan Perlis, Thamir Al-Kasab, Ardalan Ahmad, Estee Goldberg, Kamel Fadak, Rashid Sayid, Antonio Finelli, Girish Kulkarni, Rob Hamilton, Alexandre Zlotta, Sangeet Ghai, Neil Fleshner
PURPOSE: Prostate cancer over diagnosis and overtreatment are concerns for clinicians and policy makers. Multiparametric magnetic resonance imaging and the PCA3 (prostate cancer antigen 3) urine test select for clinically significant cases. We explored how well the tests performed together with previous biopsies. MATERIALS AND METHODS: In accordance with ethics committee approval we collected clinicopathological data on all patients in whom a PCA3 test was done from January 2011 to June 2016...
November 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29129398/genomic-markers-in-prostate-cancer-decision-making
#11
REVIEW
Vito Cucchiara, Matthew R Cooperberg, Marc Dall'Era, Daniel W Lin, Francesco Montorsi, Jack A Schalken, Christopher P Evans
CONTEXT: Although the widespread use of prostate-specific antigen (PSA) has led to an early detection of prostate cancer (PCa) and a reduction of metastatic disease at diagnosis, PSA remains one of the most controversial biomarkers due to its limited specificity. As part of emerging efforts to improve both detection and management decision making, a number of new genomic tools have recently been developed. OBJECTIVE: This review summarizes the ability of genomic biomarkers to recognize men at high risk of developing PCa, discriminate clinically insignificant and aggressive tumors, and facilitate the selection of therapies in patients with advanced disease...
November 9, 2017: European Urology
https://www.readbyqxmd.com/read/28992280/plasma-biomarkers-improve-prediction-of-diabetic-kidney-disease-in-adults-with-type-1-diabetes-over-a-12-year-follow-up-cacti-study
#12
Petter Bjornstad, Laura Pyle, David Z I Cherney, Richard J Johnson, Rachel Sippl, Randy Wong, Marian Rewers, Janet K Snell-Bergeon
Background: The objective of the study was to determine whether plasma biomarkers of kidney injury improve the prediction of diabetic kidney disease (DKD) in adults with type 1 diabetes (T1D) over a period of 12 years. Methods: Participants ( n  = 527, 53% females) in the Coronary Artery Calcification in T1D (CACTI) Study were examined during 2002-04, at a mean (± standard deviation) age of 39.6 ± 9.0 years with 24.8 years as the median duration of diabetes...
August 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28969674/development-and-validation-of-a-questionnaire-assessing-the-quality-of-life-impact-of-colour-blindness-cbqol
#13
John A Barry, Susan Mollan, Michael A Burdon, Michelle Jenkins, Alastair K Denniston
BACKGROUND: Congenital colour vision deficiency (CVD), commonly called 'colour blindness', affects around 8% of men and 0.4% of women. Although many aspects of health (e.g. change in colour of urine) and healthcare (e.g. coloured medication, colour-coded diagnostic tests), and modern life depend upon colour coding (e.g. graphs, maps, signals), the impact of colour blindness on everyday life is not generally considered a topic of importance. This study is the first to create and validate a questionnaire measuring the quality of life (QoL) impact of being colour blind...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28938580/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#14
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900493/a-multi-center-prospective-study-to-validate-an-algorithm-using-urine-and-plasma-biomarkers-for-predicting-gleason-%C3%A2-3-4-prostate-cancer-on-biopsy
#15
Maher Albitar, Wanlong Ma, Lars Lund, Babak Shahbaba, Edward Uchio, Soren Feddersen, Donald Moylan, Kirk Wojno, Neal Shore
Background: Unnecessary biopsies and overdiagnosis of prostate cancer (PCa) remain a serious healthcare problem. We have previously shown that urine- and plasma-based prostate-specific biomarkers when combined can predict high grade prostate cancer (PCa). To further validate this test, we performed a prospective multicenter study recruiting patients from community-based practices. Patients and Methods: Urine and plasma samples from 2528 men were tested prospectively. Results were correlated with biopsy findings, if a biopsy was performed as deemed necessary by the practicing urologist...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28853167/a-urinary-biomarker-based-risk-score-correlates-with-multiparametric-mri-for-prostate-cancer-detection
#16
Rianne J Hendriks, Marloes M G van der Leest, Siebren Dijkstra, Jelle O Barentsz, Wim Van Criekinge, Christina A Hulsbergen-van de Kaa, Jack A Schalken, Peter F A Mulders, Inge M van Oort
BACKGROUND: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection. METHODS: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies...
October 2017: Prostate
https://www.readbyqxmd.com/read/28783586/dynamic-surface-enhanced-raman-spectroscopy-and-chemometric-methods-for-fast-detection-and-intelligent-identification-of-methamphetamine-and-3-4-methylenedioxy-methamphetamine-in-human-urine
#17
Shizhuang Weng, Ronglu Dong, Zede Zhu, Dongyan Zhang, Jinling Zhao, Linsheng Huang, Dong Liang
Conventional Surface-Enhanced Raman Spectroscopy (SERS) for fast detection of drugs in urine on the portable Raman spectrometer remains challenges because of low sensitivity and unreliable Raman signal, and spectra process with manual intervention. Here, we develop a novel detection method of drugs in urine using chemometric methods and dynamic SERS (D-SERS) with mPEG-SH coated gold nanorods (GNRs). D-SERS combined with the uniform GNRs can obtain giant enhancement, and the signal is also of high reproducibility...
January 15, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28730787/association-of-ferritin-with-prostate-cancer
#18
Qiang Su, Ting Lei, Man Zhang
PURPOSE: Prostate specific antigen (PSA) has been widely used as the unique serum biomarker for the diagnosis and/ or pre-diagnosis of prostate cancer (PCa). However, the diagnostic value of PSA is a subject of ongoing debate owing to its lack of specificity, especially when the PSA level is moderately increased (e.g., 4-10 ng/ml). Thus, we suggest the need for identification of a new biomarker to discriminate PCa cases from benign prostatic hyperplasia (BPH) and normal controls (N). METHODS: Urine or tissue samples of PCa patients, BPH patients, and normal controls were systematically collected...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28717416/feasibility-of-urinary-extracellular-vesicle-proteome-profiling-using-a-robust-and-simple-clinically-applicable-isolation-method
#19
Irene V Bijnsdorp, Olga Maxouri, Aarzo Kardar, Tim Schelfhorst, Sander R Piersma, Thang V Pham, Andre Vis, R Jeroen van Moorselaar, Connie R Jimenez
Extracellular vesicles (EVs) secreted by prostate cancer (PCa) cells contain specific biomarkers and can be isolated from urine. Collection of urine is not invasive, and therefore urinary EVs represent a liquid biopsy for diagnostic and prognostic testing for PCa. In this study, we optimised urinary EV isolation using a method based on heat shock proteins and compared it to gold-standard ultracentrifugation. The urinary EV isolation protocol using the Vn96-peptide is easier, time convenient (≈1.5 h) and no special equipment is needed, in contrast to ultracentrifugation protocol (>3...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28704754/metabolomics-study-of-cadmium-induced-diabetic-nephropathy-and-protective-effect-of-caffeic-acid-phenethyl-ester-using-uplc-q-tof-ms-combined-with-pattern-recognition
#20
Pin Gong, Xiangna Chang, Xuefeng Chen, Xiaohuan Bai, He Wen, Sihui Pi, Wenjuan Yang, Lan Wang, Fuxin Chen
Diabetic nephropathy (DN) is the most severe complication of diabetes and multiple factors are involved in the pathogenesis of DN. Among them, cadmium (Cd) acts as a risk factor inducing the occurrence of DN. The present study focused on investigating the protective role of caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, against Cd-induced DN in mice based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS)and pattern recognition...
September 2017: Environmental Toxicology and Pharmacology
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