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Homografts

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https://www.readbyqxmd.com/read/29127746/-surgical-treatment-of-aortic-root-aneurysm-comparison-of-bentall-procedure-and-david-reimplantation-of-aortic-valve
#1
Jiří Ničovský, Jiří Ondrášek, Jan Černý, Daniela Žáková, Petr Němec
INTRODUCTION: The aortic root aneurysm is associated with a more frequent occurrence of aortic dissection and development of aortic regurgitation. The aim of this study was to compare outcomes of composite graft replacement and valve sparing root replacement in treating aortic root aneurysms. METHODS: From January 2006 to December 2015 a total of 137 patients (mean age 46.3 ± 14.5, range 16-65) underwent elective surgery for aortic root aneurysm without valvular structural defects...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29108244/tipe1-function-as-a-prognosis-predictor-and-negative-regulator-of-lung-cancer
#2
Xiaocheng Wu, Yunmiao Ma, Ji Cheng, Xia Li, Hui Zheng, Li Jiang, Renjie Zhou
TIPE1 (tumor necrosis factor-α-induced protein 8-like 1 or TNFAIP8L1) belongs to the TIPE (TNFAIP8) family, which act as a regulator of cell death. However, the expression and biologic functions of TIPE1 in lung cancer are largely unknown. Here, we investigated the roles of TIPE1 in lung cancer. Evaluated by qRT-PCR and immunohistochemical staining, lower TIPE1 mRNA and protein expression was found in the lung tumor tissue, compared with adjacent non-tumor tissues, which positively correlated with tumor patient survival...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29078248/-management-of-endograft-infection-after-evar-and-tevar-a-case-series-and-literature-review
#3
Thomas Betz, Ingolf Töpel, Markus Steinbauer, Christian Uhl
Introduction Endograft infection after EVAR (Endovascular aortic repair) or TEVAR (Thoracic endovascular aortic repair) is a rare but severe complication with high mortality. As the number of patients with endovascular aneurysm repair has increased over the last decade, the number of patients with endograft infection might also have increased. However, no guideline defines the treatment of endograft infection. Diagnosis is difficult and depends on clinical symptoms, radiological imaging and blood cultures. Surgery with graft excision, debridement and revascularisation should be proposed...
October 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29050225/hcarg-commd5-inhibits-erbb-receptor-driven-renal-cell-carcinoma
#4
Hiroyuki Matsuda, Carole G Campion, Kyoko Fujiwara, Jin Ikeda, Suzanne Cossette, Thomas Verissimo, Maiko Ogasawara, Louis Gaboury, Kosuke Saito, Kenya Yamaguchi, Satoru Takahashi, Morito Endo, Noboru Fukuda, Masayoshi Soma, Pavel Hamet, Johanne Tremblay
Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is highly expressed in renal proximal tubules, where it contributes to the control of cell proliferation and differentiation. HCaRG accelerates tubular repair by facilitating re-differentiation of injured proximal tubular epithelial cells, thus improving mouse survival after acute kidney injury. Sustained hyper-proliferation and de-differentiation are important hallmarks of tumor progression. Here, we demonstrate that cancer cells overexpressing HCaRG maintain a more differentiated phenotype, while several of them undergo autophagic cell death...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049550/mid-term-outcomes-of-congenital-mitral-valve-surgery-shone-s-syndrome-is-a-risk-factor-for-death-and-reintervention
#5
Koichi Sughimoto, Igor E Konstantinov, Yves d'Udekem, Johann Brink, Diana Zannino, Christian P Brizard
OBJECTIVES: To study the recent trends and outcomes of congenital mitral valve surgery in children. METHODS: From 2008 to 2014, 84 procedures in 66 consecutive patients (41 procedures in 31 patients with mitral stenosis and 43 procedures in 35 patients with mitral regurgitation) were retrospectively evaluated. The mean age at surgery was 4.3 ± 5.4 years, and 27 patients (41%) were neonates or infants. RESULTS: Seven (11%) patients died during the follow-up period of 3...
November 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29029050/small-sized-conduits-in-the-right-ventricular-outflow-tract-in-young-children-bicuspidalized-homografts-are-a-good-alternative-to-standard-conduits
#6
Katrien François, Katya De Groote, Kristof Vandekerckhove, Hans De Wilde, Daniel De Wolf, Thierry Bové
OBJECTIVES: Downsizing a homograft (HG) through bicuspidalization has been used for more than 2 decades to overcome the shortage of small-sized conduits for reconstruction of the right ventricular outflow tract (RVOT) in young children. Our goal was to investigate the durability of bicuspidalized HGs compared with other small HGs. METHODS: A retrospective analysis of 93 conduits ≤20 mm, implanted over 23 years, was performed. The end-points were survival, structural valve degeneration and conduit replacement...
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029030/outcomes-of-surgery-for-infective-endocarditis-a-single-centre-experience-of-801-patients
#7
Sameh M Said, Zaid M Abdelsattar, Hartzell V Schaff, Kevin L Greason, Richard C Daly, Alberto Pochettino, Lyle D Joyce, Joseph A Dearani
OBJECTIVES: Infective endocarditis (IE) remains a life-threatening disease, despite the improvement in diagnostic and therapeutic measures. We reviewed our outcomes for all adults who underwent surgery for endocarditis at our centre. METHODS: Between January 1995 and December 2013, 801 patients [586 men (73%)] underwent surgery for IE. Mean age was 60 ± 14.7 years. Native endocarditis (NE) was present in 372 patients (46%), and 379 (47%) patients had active IE...
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29027509/multiply-adjusted-comparisons-a-meta-analysis-method-to-compare-single-arm-clinical-trial-data-to-literature-results-regarding-a-competitor
#8
Dietmar Boethig, Hartmut Hecker
Prospective randomized controlled trials are difficult to obtain if a promising new therapy has to be tested against seemingly obsolete alternatives. One method to address this problem is to compare the results of (multicentre) trials to literature results. However, previous treatment-era changes and population-dependent results complicate objective comparisons. The presented approach describes a method to objectify such comparisons in cases in which individual raw data regarding a new therapy have to be compared to summary results regarding a conventional alternative published in the literature...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28987279/long-term-evaluation-of-the-ross-procedure-in-acute-infective-endocarditis
#9
Thomas Ratschiller, Sames-Dolzer Eva, Patrick Paulus, Wolfgang Schimetta, Hannes Müller, Andreas F Zierer, Rudolf Mair
OBJECTIVE: Optimal valve substitute for young patients with aortic valve endocarditis remains controversial. Given its better resistance to infection, the Ross procedure is an attractive alternative to prosthetic valve replacement or homograft implantation. The objective of this study was to assess long-term outcomes of the Ross procedure in this indication. METHODS: From 01/1991 to 04/2017, 190 patients underwent a Ross procedure at our institution. Acute endocarditis was the indication for operation in 19 patients, including 6 patients with a bicuspid aortic valve...
October 5, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28974283/is-mesocardia-with-left-sided-caval-vein-draining-to-coronary-sinus-a-contraindication-for-a-percutaneous-pulmonary-valve-implantation-a-case-description
#10
Marinos Kantzis, Christoph M Happel, Nikolaus A Haas
Introduction Although the right jugular vein approach for percutaneous pulmonary valve implantation is well described, there are no reports that describe a percutaneous pulmonary valve implantation through a left superior caval vein to coronary sinus pathway. Case A 14-year-old female with tetralogy of Fallot, mesocardia, left superior caval vein draining into the coronary sinus, and hemiazygos continuation of the inferior caval vein underwent ventricular septal defect closure, with homograft insertion from the right ventricle to the pulmonary artery, patch augmentation of the left pulmonary artery, and creation of an atrial communication...
October 4, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28960050/redo-root-replacement-using-the-ross-in-valsalva-technique
#11
Shakil Farid, Saadallah Tamer, Laurent de Kerchove, Gebrine El Khoury
The Ross procedure is an alternative option for young and middle-aged patients needing aortic valve replacement. We present an interesting case where the patient had a preexisting aortic homograft that was implanted because of previous infective endocarditis with aortic root abscess. The patient presented with biological degeneration of the homograft with resultant severe stenosis as well as insufficiency. We performed a redo root surgery to replace the homograft with the Ross procedure by using the autograft inclusion into a vascular graft technique...
August 4, 2017: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28955397/how-long-can-the-next-intervention-be-delayed-after-balloon-dilatation-of-homograft-in-the-pulmonary-position
#12
Hye-In Jeong, Jinyoung Song, Eun Young Choi, Sung Ho Kim, Jun Huh, I-Seok Kang, Ji Hyuk Yang, Tae Gook Jun
BACKGROUND AND OBJECTIVES: We investigated the effectiveness of balloon dilatation of homograft conduits in the pulmonary position in delaying surgical replacement. SUBJECTS AND METHODS: We reviewed the medical records of patients who underwent balloon dilatation of their homograft in the pulmonary position from 2001 to 2015. The pressure gradient and ratio of right ventricular pressure were measured before and after the procedure. The primary goal of this study was to evaluate the parameters associated with the interval to next surgical or catheter intervention...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28948487/how-to-treat-aortic-graft-infection-with-a-special-emphasis-on-xeno-pericardial-aortic-tube-grafts
#13
Thierry Carrel, Lars Englberger, Jürg Schmidli
Infection of a vascular prosthesis or endovascular stent-graft is probably the most serious complication that may occur after implantation and dramatically affects the patient's outcome. The most common etiology of graft and/or prosthetic valve infection is usually wound-related infection, followed by seeding from distant infection sites (lung, urinary tract). Surgical treatment is almost always required but even after surgery, morbidity can be significant. Operative procedure must be tailored according to the individual patient and to the experience of the surgical team...
September 25, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28919137/pseudoaneurysm-complicating-right-ventricle-to-pulmonary-artery-conduit-surgery-incidence-and-risk-factors
#14
Michelle C Sykes, Meena Nathan, Stephen P Sanders, Kimberlee Gauvreau, Frank A Pigula, Jonathan Rhodes
OBJECTIVES: Although pseudoaneurysm is an uncommon complication after right ventricle-to-pulmonary artery conduit placement, it has the potential to cause significant morbidity and mortality. METHODS: We performed a review of patients with pseudoaneurysms diagnosed at our institution in a 20-year period (from 1995 through 2015) and compared their clinical characteristics with a group of age- and sex-matched control patients. RESULTS: We found that younger age, smaller size, the diagnosis of tetralogy of Fallot, the use of a pulmonary homograft conduit, the presence of an unrestrictive ventricular septal defect after conduit placement, and having at least systemic right ventricular pressure were all more common in patients who had pseudoaneurysms develop...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28894378/initial-experience-of-correlating-diffusion-spectral-parameters-with-histopathologic-indexes-in-murine-colorectal-tumor-homografts
#15
Xiao-Yan Zhang, Xiao-Ting Li, Jia Sun, Ying-Shi Sun
PURPOSE: To determine the correlation between continuously distributed diffusion-weighted image (DWI)-derived parameters and histopathologic indexes. METHODS: Fifty-four mice bearing HCT-116 colorectal tumors were included for analysis; 12 mice were used for continuous observation, and the other 42 mice were used for break-point observation. All mice were randomly divided into radiotherapy and non-radiotherapy groups. Optical imaging and MRI were performed at different time points according to radiotherapy regimen (baseline, 24 h, 48 h, 72 h, 7 d, 14 d, and 28 d)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28894059/-re-operation-for-saccular-aneurysm-after-ascending-aortic-replacement-with-homograft-report-of-a-case
#16
Masahiro Ikeda, Toshihisa Asakura, Kazuhiko Uwabe, Kozo Morita, Atsushi Iguchi, Hiroshi Niinami
A 62-years-old female had undergone ascending aortic replacement with homograft for graft infection and mediastinitis after initial replacement of ascending aorta due to acute type A dissection. Ten years after homograft replacement, follow up computed tomography showed acute growing saccular aneurysm of the homograft without infectious symptoms. We urgently performed Bentall procedure and hemiarch replacement successfully. Pathological diagnosis was true aneurysm of the homograft. She was discharged from hospital without any complication and has been quite uneventful 7 years after surgery...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28882144/sutureless-aortic-valve-replacement-in-a-calcified-homograft-combined-with-mitral-valve-replacement
#17
Ferdi Akca, Kayan Lam, Ibrahim Özdemir, Erwin Tan
BACKGROUND: Aortic valve replacement in a patient with an aortic homograft can be very challenging, especially when concomitant mitral valve surgery needs to be performed. CASE PRESENTATION: We report a case of implantation of a sutureless aortic valve bioprosthesis combined with mitral valve replacement in a patient with a severely calcified aortic homograft where conventional valve replacement was technically unfeasible. CONCLUSIONS: We believe that sutureless AVR is a viable option especially for young patients with a high surgical risk where conventional valve replacement cannot be achieved...
September 7, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28793902/30-year-experience-of-fontan-surgery-single-centre-s-data
#18
Laurynas Bezuska, Virgilijus Lebetkevicius, Rita Sudikiene, Daina Liekiene, Virgilijus Tarutis
BACKGROUND: The Fontan procedure has been modified several times since it was introduced into practice in 1968. As many patients now survive to adulthood, attention is directed towards their clinical status and late morbidity. We report our surgical experience of 30 years in Fontan procedures. METHODS: From January 1985 to January 2015, 80 patients underwent Fontan surgery. Twenty-one patients received an atrio-pulmonary Fontan (Group I), four patients underwent total cavopulmonary connection (TCPC) with an intra-atrial lateral tunnel (Group II), six patients received extra-cardiac TCPC with an aortic homograft (group III) and 49 patients received extra-cardiac TCPC with an expanded polytetrafluoroethylene conduit...
August 9, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28775235/tipe1-function-as-a-prognosis-predictor-and-negative-regulator-of-lung-cancer
#19
Xiaocheng Wu, Yunmiao Ma, Ji Cheng, Xia Li, Hui Zheng, Li Jiang, Renjie Zhou
TIPE1 (tumor necrosis factor-α-induced protein 8-like 1 or TNFAIP8L1) belongs to the TIPE (TNFAIP8) family, which act as a regulator of cell death. However, the expression and biologic functions of TIPE1 in lung cancer are largely unknown. Here, we investigated the roles of TIPE1 in lung cancer. Evaluated by qRT-PCR and immunohistochemical staining, lower TIPE1 mRNA and protein expression was found in the lung tumor tissue, compared with adjacent non-tumor tissues, which positively correlated with tumor patient survival...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766119/professor-yves-goffin-m-d-ph-d-the-founder-of-the-european-homograft-bank-ehb-past-away
#20
Ramadan Jashari, Béatrice Van Hoeck
No abstract text is available yet for this article.
August 1, 2017: Cell and Tissue Banking
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