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https://www.readbyqxmd.com/read/28731281/glycaemic-control-and-the-risk-of-hospitalisation-for-infection-in-patients-with-type-2-diabetes-hong-kong-diabetes-registry
#1
Andrea O Y Luk, Eric S H Lau, Kitty K T Cheung, Alice P Kong, Ronald C W Ma, Risa Ozaki, Francis C C Chow, Wing-Yee So, Juliana C N Chan
BACKGROUND: Infection occurs more commonly in diabetic compared to general population and is an under-recognised but important morbidity in patients with diabetes. We examined the impact of glycaemic control on hospitalisation for infection in a large prospective cohort of Chinese adults with type 2 diabetes. METHODS: Between July 1994 and June 2014, 22,846 patients with type 2 diabetes underwent detailed assessment of metabolic control and diabetes complications...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28730315/comparison-of-nellcor%C3%A2-pm1000n-and-masimo-radical-7-%C3%A2-for-detecting-apnea-in-volunteers
#2
Chanatthee Kitsiripant, Tomoko Fukada, Hiroko Iwakiri, Yuri Tsuchiya, Makoto Ozaki, Minoru Nomura
PURPOSE: Although capnography is considered the gold standard for monitoring of ventilation, it may not work accurately in some situations. We compared the performance of two non-invasive continuous respiratory rate (RR) monitors that are alternatives for the detection of respiratory depression. METHODS: Fifty healthy volunteers ≥20 years old were enrolled in this study. After monitoring of the volunteers was started by the Masimo Radical-7(®) and Nellcor™ PM1000N, they breathed at the rate of 12 breaths/min for 3 min and then stopped breathing...
July 20, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28725007/far-and-deep-ultraviolet-surface-plasmon-resonance-sensors-working-in-aqueous-solutions-using-aluminum-thin-films
#3
Ichiro Tanabe, Yoshito Y Tanaka, Koji Watari, Taras Hanulia, Takeyoshi Goto, Wataru Inami, Yoshimasa Kawata, Yukihiro Ozaki
Surface plasmon resonance (SPR) sensors detect refractive index changes on metal thin films and are frequently used in aqueous solutions as bio- and chemical-sensors. Recently, we proposed new SPR sensors using aluminum (Al) thin films that work in the far- and deep-ultraviolet (FUV-DUV, 120-300 nm) regions and investigated SPR properties by an attenuated total reflectance (ATR) based spectrometer. The FUV-DUV-SPR sensors are expected to have three advantages compared to visible-SPR sensors: higher sensitivity, material selectivity, and surface specificity...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714951/rates-distribution-and-implications-of-postzygotic-mosaic-mutations-in-autism-spectrum-disorder
#4
Elaine T Lim, Mohammed Uddin, Silvia De Rubeis, Yingleong Chan, Anne S Kamumbu, Xiaochang Zhang, Alissa M D'Gama, Sonia N Kim, Robert Sean Hill, Arthur P Goldberg, Christopher Poultney, Nancy J Minshew, Itaru Kushima, Branko Aleksic, Norio Ozaki, Mara Parellada, Celso Arango, Maria J Penzol, Angel Carracedo, Alexander Kolevzon, Christina M Hultman, Lauren A Weiss, Menachem Fromer, Andreas G Chiocchetti, Christine M Freitag, George M Church, Stephen W Scherer, Joseph D Buxbaum, Christopher A Walsh
We systematically analyzed postzygotic mutations (PZMs) in whole-exome sequences from the largest collection of trios (5,947) with autism spectrum disorder (ASD) available, including 282 unpublished trios, and performed resequencing using multiple independent technologies. We identified 7.5% of de novo mutations as PZMs, 83.3% of which were not described in previous studies. Damaging, nonsynonymous PZMs within critical exons of prenatally expressed genes were more common in ASD probands than controls (P < 1 × 10(-6)), and genes carrying these PZMs were enriched for expression in the amygdala (P = 5...
July 17, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28714468/high-order-harmonic-generation-from-the-dressed-autoionizing-states
#5
M A Fareed, V V Strelkov, N Thiré, S Mondal, B E Schmidt, F Légaré, T Ozaki
In high-order harmonic generation, resonant harmonics (RH) are sources of intense, coherent extreme-ultraviolet radiation. However, intensity enhancement of RH only occurs for a single harmonic order, making it challenging to generate short attosecond pulses. Moreover, the mechanism involved behind such RH was circumstantial, because of the lack of direct experimental proofs. Here, we demonstrate the exact quantum paths that electron follows for RH generation using tin, showing that it involves not only the autoionizing state, but also a harmonic generation from dressed-AIS that appears as two coherent satellite harmonics at frequencies ±2Ω from the RH (Ω represents laser frequency)...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28707312/selective-pd-ii-catalyzed-carbonylation-of-methylene-beta-c-h-bonds-in-aliphatic-amines
#6
Matthew James Gaunt, Jaime Cabrera-Pardo, Aaron Trowbridge, Manuel Nappi, Kyohei Ozaki
Pd(II)-catalyzed C-H carbonylation of methylene C-H bonds in secondary aliphatic amines leads to the formation trans-disubstituted beta-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields of the beta-lactam products.
July 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28707050/tensile-strength-of-the-pullout-repair-technique-for-the-medial-meniscus-posterior-root-tear-a-porcine-study
#7
Masataka Fujii, Takayuki Furumatsu, Haowei Xue, Shinichi Miyazawa, Yuya Kodama, Tomohito Hino, Yusuke Kamatsuki, Toshifumi Ozaki
PURPOSE: The purpose of this study was to compare the load-to-failure of different common suturing techniques with a new technique for the medial meniscus posterior root tear (MMPRT). METHODS: Thirty porcine medial menisci were randomly assigned to three suturing techniques used for transtibial pullout repair of the MMPRT (n = 10 per group). Three different meniscal suture configurations were studied: the two simple suture (TSS) technique, the conventional modified Mason-Allen suture (MMA) technique, and the new MMA technique using the FasT-Fix combined with the Ultrabraid (F-MMA)...
July 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28705457/a-novel-c-type-lectin-gene-is-a-strong-candidate-gene-for-benedenia-disease-resistance-in-japanese-yellowtail-seriola-quinqueradiata
#8
Masatoshi Nakamoto, Yusuke Takeuchi, Kazuki Akita, Ryo Kumagai, Junpei Suzuki, Takashi Koyama, Tsutomu Noda, Kazunori Yoshida, Akiyuki Ozaki, Kazuo Araki, Takashi Sakamoto
Little is known about mechanisms of resistance to parasitic diseases in marine finfish. Benedenia disease is caused by infection by the monogenean parasite Benedenia seriolae. Previous quantitative trait locus (QTL) analyses have identified a major QTL associated with resistance to Benedenia disease in linkage group Squ2 of the Japanese yellowtail/amberjack Seriola quinqueradiata. To uncover the bioregulatory mechanism of Benedenia disease resistance, complete Illumina sequencing of BAC clones carrying genomic DNA for the QTL region in linkage group Squ2 was performed to reveal a novel C-type lectin in this region...
July 10, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28698857/ultrasound-guided-sternal-bone-marrow-aspiration
#9
Yusuke Asakura, Maho Kinoshita, Yusuke Kasuya, Shiori Sakuma, Makoto Ozaki
No abstract text is available yet for this article.
June 2017: Blood Research
https://www.readbyqxmd.com/read/28697125/the-prognosis-of-severe-acute-pancreatitis-varies-according-to-the-segment-presenting-with-low-enhanced-pancreatic-parenchyma-on-early-contrast-enhanced-computed-tomography-a-multicenter-cohort-study
#10
Katsuya Kitamura, Masayasu Horibe, Masamitsu Sanui, Mitsuhito Sasaki, Akira Yamamiya, Yu Ishii, Hitoshi Yoshida, Hirotaka Sawano, Takashi Goto, Tsukasa Ikeura, Tsuyoshi Hamada, Takuya Oda, Hideto Yasuda, Yuki Ogura, Dai Miyazaki, Kaoru Hirose, Nobutaka Chiba, Tetsu Ozaki, Takahiro Yamashita, Toshitaka Koinuma, Taku Oshima, Tomonori Yamamoto, Morihisa Hirota, Yoshinori Azumi, Keiji Nagata, Nobuyuki Saito, Mizuki Sato, Kyohei Miyamoto, Eisuke Iwasaki, Takanori Kanai, Toshihiko Mayumi
OBJECTIVE: The aim of this study was to investigate the outcomes of severe acute pancreatitis (SAP) according to the segment presenting with low enhanced pancreatic parenchyma (LEPP) on early contrast-enhanced computed tomography. METHODS: This was a post hoc analysis of a multicenter, retrospective study conducted at 44 institutions in Japan. Patients diagnosed as having SAP according to the Japanese Severity Score between January 2009 and December 2013 were included...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28693719/type-xvii-collagen-coordinates-proliferation-in-the-interfollicular-epidermis
#11
Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M Watt, Hiroshi Shimizu
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28693182/location-of-the-meso-pancreatoduodenum-as-a-regional-lymphatic-basin-for-pancreatic-head-carcinoma
#12
Hirofumi Terakawa, Hirohisa Kitagawa, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Hisatoshi Nakagawara, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Sachio Fushida, Noriyuki Ozaki, Tetsuo Ohta
The meso-pancreatoduodenum is the primary site of tumor infiltration in patients with pancreatic head cancer, with numerous patients exhibiting lymph node metastases. Effective dissection of the regional lymphatic basin requires knowledge of the patterns of the arterial branches. The present study examined the patterns of the arteries feeding the pancreatic head and the distribution of the meso-pancreatoduodenum. The present study included 123 patients with pancreatic cancer who underwent contrast-enhanced preoperative 64-multidetector-computed tomography to determine the routes of the inferior pancreaticoduodenal and first jejunal arteries...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691164/pick-s-disease-with-neuronal-four-repeat-tau-accumulation-in-the-basal-ganglia-brain-stem-nuclei-and-cerebellum
#13
Chikako Ikeda, Osamu Yokota, Tomoko Miki, Shintaro Takenoshita, Hideki Ishizu, Yoko Mori, Kiyohiro Yamazaki, Yuki Ozaki, Shu-Ichi Ueno, Takeshi Ishihara, Masato Hasegawa, Seishi Terada, Norihito Yamada
It is very rare that cases of Pick's disease, a representative three-repeat (3R) tauopathy, also have significant four-repeat (4R) tau accumulation. Here, we report a Pick's disease case that clinically showed behavioral variant frontotemporal dementia without motor disturbance during the course, and pathologically had 3R tau-positive Pick bodies as well as numerous 4R tau-positive neuronal cytoplasmic inclusions (NCIs). Abundant 3R tau-positive 4R tau-negative spherical or horseshoe-shaped Pick bodies were found in the frontotemporal cortex, limbic region, striatum and pontine nucleus...
July 9, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28685948/role-of-zoledronic-acid-in-oncolytic-virotherapy-promotion-of-antitumor-effect-and-prevention-of-bone-destruction
#14
Yasuaki Yamakawa, Hiroshi Tazawa, Joe Hasei, Shuhei Osaki, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Kouji Uotani, Tomohiro Fujiwara, Aki Yoshida, Toshiyuki Kunisada, Yasuo Urata, Shunsuke Kagawa, Toshifumi Ozaki, Toshiyoshi Fujiwara
Osteosarcoma is an aggressive malignant bone tumor that causes bone destruction. Although tumor-specific replicating oncolytic adenovirus OBP-301 induces an antitumor effect in an osteosarcoma tumor, it cannot prevent bone destruction. Zoledronic acid (ZOL) is a clinically available agent that inhibits bone destruction. In this study, we investigated the potential of combination therapy with OBP-301 and ZOL against osteosarcomas with bone destruction. The antitumor activity of OBP-301 and ZOL in monotherapy or combination therapy was assessed using 3 human osteosarcoma cell lines (143B, MNNG/HOS, SaOS-2)...
July 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/28684209/off-hours-presentation-does-not-affect-in-hospital-mortality-of-japanese-patients-with-acute-myocardial-infarction-j-minuet-substudy
#15
Manabu Ogita, Satoru Suwa, Hideki Ebina, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoshi Yasuda, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Masaaki Uematsu, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Seiji Hokimoto, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shiro Uemura, Tetsuya Toubaru, Keijiro Saku, Shigeru Oshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Masaharu Ishihara
BACKGROUND: The association between patients with acute myocardial infarction (AMI) who present during off-hours and clinical outcomes has not been fully elucidated. METHODS: We investigated 3283 consecutive patients with AMI who were selected from a prospective, nationwide, multicenter registry (J-MINUET) database comprising 28 institutions in Japan between July 2012 and March 2014 to determine the current impact of off-hours presentation on in-hospital mortality among Japanese patients with AMI...
July 3, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28683430/loading-and-removal-of-pahs-fragrance-compounds-triclosan-and-toxicity-by-composting-process-from-sewage-sludge
#16
Noriatsu Ozaki, Akihiro Nakazato, Kazuki Nakashima, Tomonori Kindaichi, Akiyoshi Ohashi
Although the production of compost from sewage sludge is well established in developed countries, the use of sludge-based compost may represent a source of pollutants. The present study assessed the levels of potentially harmful compounds in compost as well as their rates of decrease during composting. The concentrations of 16 polycyclic aromatic hydrocarbons (PAHs), three fragrance compounds (OTNE, HHCB and AHTN) and triclosan were determined in the initial sewage sludge and in compost over the span of 1year...
July 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28682159/association-of-nod2-mutations-with-aggressive-periodontitis
#17
T Sudo, Y Okada, K Ozaki, K Urayama, M Kanai, H Kobayashi, M Gokyu, Y Izumi, T Tanaka
Aggressive periodontitis (AgP) is characterized by rapid alveolar bone destruction and tooth loss early in life, and its etiology remains unclear. To explore the genetic risk factors of AgP, we performed genome-wide single-nucleotide polymorphism genotyping for identity-by-descent mapping and identified 32 distinct candidate loci, followed by whole exome sequencing with 2 pedigrees of AgP consisting of 3 cases and 1 control in 1 family and 2 sibling cases in the other. After variant filtering procedures and validation by targeted Sanger sequencing, we identified 2 missense mutations at 16q12 in NOD2 (p...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28674357/single-dose-rituximab-therapy-for-refractory-idiopathic-membranous-nephropathy-a-single-center-experience
#18
Takayuki Katsuno, Takenori Ozaki, Hangsoo Kim, Noritoshi Kato, Yasuhiro Suzuki, Shinichi Akiyama, Takuji Ishimoto, Tomoki Kosugi, Naotake Tsuboi, Yasuhiko Ito, Shoichi Maruyama
To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28674255/amelioration-of-the-development-of-osteoarthritis-by-daily-intake-of-%C3%AE-cryptoxanthin
#19
Gyujin Park, Tetsuhiro Horie, Kazuya Fukasawa, Kakeru Ozaki, Yuki Onishi, Takashi Kanayama, Takashi Iezaki, Katsuyuki Kaneda, Minoru Sugiura, Eiichi Hinoi
β-Cryptoxanthin, which is primarily obtained from citrus fruits such as Satsuma mandarins, is a major carotenoid routinely found in human serum. Recently, we demonstrated that daily oral intake of β-cryptoxanthin prevented ovariectomy-induced bone loss and ameliorated neuropathic pain in mice. Although β-cryptoxanthin exerts preventive effects on various lifestyle-related diseases, there have been no studies on the effect of β-cryptoxanthin on the development of osteoarthritis, the most common degenerative joint disease, which frequently leads to loss of ability and stiffness in the elderly...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28671946/depletion-of-runt-related-transcription-factor-2-runx2-enhances-saha-sensitivity-of-p53-mutated-pancreatic-cancer-cells-through-the-regulation-of-mutant-p53-and-tap63
#20
Takehiro Ogata, Mizuyo Nakamura, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Danjing Yin, Mexiang Sang, Osamu Shimozato, Toshinori Ozaki
Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this study, we have found for the first time that RUNX2/mutant p53/TAp63-regulatory axis has a pivotal role in the determination of SAHA sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells. According to our present results, MiaPaCa-2 cells responded poorly to SAHA...
2017: PloS One
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