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https://www.readbyqxmd.com/read/28522136/impact-of-red-blood-cell-distribution-width-on-non-cardiac-mortality-in-patients-with-acute-decompensated-heart-failure-with-preserved-ejection-fraction
#1
Ryo Imai, Yusuke Uemura, Takahiro Okumura, Kenji Takemoto, Tomohiro Uchikawa, Masayoshi Koyasu, Shinji Ishikawa, Satoshi Iwamiya, Yuta Ozaki, Rei Shibata, Masato Watarai, Toyoaki Murohara
BACKGROUND: The prognostic impact of red blood cell distribution width (RDW) on adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. We investigated the association between RDW values at admission and long-term prognosis in patients with acute decompensated HFpEF. METHODS: The present study enrolled 278 consecutive patients with acute decompensated HFpEF, whose RDW levels were measured at admission. We divided enrolled patients into 2 groups according to RDW value and investigated the association between RDW and patients' mortality...
May 15, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28513134/silicon-quantum-dots-in-dielectric-scattering-media-broadband-enhancement-of-effective-absorption-cross-section-by-light-trapping
#2
Hiroshi Sugimoto, Yusuke Ozaki, Minoru Fujii
We report strong enhancements of the effective absorption cross-section and photoluminescence (PL) intensity of silicon quantum dots (Si QDs) with 2.8-6.8 nm in diameter in a highly scattering dielectric medium. The scattering medium is a polymer thin film with submicron size pores inside, supporting the resonant cavity modes in the visible range. By the scattering associated with the cavity modes, efficient light trapping into a polymer film with ~1 µm in thickness is achieved, which leads to 30-40 times enhancement of the effective absorption cross-section of embedded Si QDs in a green-red wavelength range...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28512588/severe-aplastic-anemia-following-parvovirus-b19-associated-acute-hepatitis
#3
Masanori Furukawa, Kosuke Kaji, Hiroyuki Masuda, Kuniaki Ozaki, Shohei Asada, Aritoshi Koizumi, Takuya Kubo, Norihisa Nishimura, Yasuhiko Sawada, Kosuke Takeda, Tsuyoshi Mashitani, Masayuki Kubo, Itsuto Amano, Tomoyuki Ootani, Chiho Ohbayashi, Koji Murata, Tatsuichi Ann, Akira Mitoro, Hitoshi Yoshiji
Human parvovirus (HPV) B19 is linked to a variety of clinical manifestations, such as erythema infectiosum, nonimmune hydrops fetalis, and transient aplastic anemia. Although a few cases have shown HPVB19 infection as a possible causative agent for hepatitis-associated aplastic anemia (HAAA) in immunocompetent patients, most reported cases of HAAA following transient hepatitis did not have delayed remission. Here we report a rare case of severe aplastic anemia following acute hepatitis with prolonged jaundice due to HPVB19 infection in a previously healthy young male...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28507751/validation-of-the-efficacy-of-the-prognostic-factor-score-in-the-japanese-severity-criteria-for-severe-acute-pancreatitis-a-large-multicenter-study
#4
Tsukasa Ikeura, Masayasu Horibe, Masamitsu Sanui, Mitsuhito Sasaki, Yasuyuki Kuwagata, Kenichiro Nishi, Shuji Kariya, Hirotaka Sawano, Takashi Goto, Tsuyoshi Hamada, Takuya Oda, Hideto Yasuda, Yuki Ogura, Dai Miyazaki, Kaoru Hirose, Katsuya Kitamura, Nobutaka Chiba, Tetsu Ozaki, Takahiro Yamashita, Toshitaka Koinuma, Taku Oshima, Tomonori Yamamoto, Morihisa Hirota, Satoshi Yamamoto, Kyoji Oe, Tetsuya Ito, Eisuke Iwasaki, Takanori Kanai, Kazuichi Okazaki, Toshihiko Mayumi
BACKGROUND: The Japanese severity criteria for acute pancreatitis (AP), which consist of a prognostic factor score and contrast-enhanced computed tomography grade, have been widely used in Japan. OBJECTIVE: This large multicenter retrospective study was conducted to validate the predictive value of the prognostic factor score for mortality and complications in severe AP patients in comparison to the Acute Physiology and Chronic Health Evaluation II (APACHE II) score...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28506309/social-isolation-and-cancer-management-advanced-rectal-cancer-with-patient-delay-following-the-2011-triple-disaster-in-fukushima-japan-a-case-report
#5
Akihiko Ozaki, Claire Leppold, Toyoaki Sawano, Masaharu Tsubokura, Manabu Tsukada, Tetsuya Tanimoto, Masahiro Kami, Hiromichi Ohira
BACKGROUND: Little is known about the effects of social isolation in the elderly on their process of gaining health information and seeking health care. CASE PRESENTATION: In March 2011, Fukushima, Japan experienced an earthquake, tsunami, and nuclear disaster, also known as Japan's triple disaster. In June 2016, an 80-year-old Japanese man, who lived alone after divorce at the age of 42, presented to our hospital with bloody stools and dizziness. Although his bloody stools initially occurred in May 2015, a year earlier, he did not pursue the possibility of malignancy...
May 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28504113/prognosis-of-spontaneous-coronary-artery-dissection-treated-by-percutaneous-coronary-intervention-with-optical-coherence-tomography
#6
Tsuyoshi Nishiguchi, Atsushi Tanaka, Akira Taruya, Yuichi Ozaki, Mai Nakai, Ikuko Teraguchi, Shingo Ota, Akio Kuroi, Takeyoshi Kameyama, Takashi Yamano, Tomoyuki Yamaguchi, Yoshiki Matsuo, Yasushi Ino, Takashi Kubo, Takeshi Hozumi, Takashi Akasaka
BACKGROUND: Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI). The aim of this study was to investigate clinical outcomes of SCAD treated by optical coherence tomography (OCT)-guided PCI. METHODS: This study consisted of consecutive 306 patients with acute coronary syndrome (ACS) who underwent OCT-guided PCI...
May 11, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28500540/prediction-of-sudden-cardiac-death-in-patients-with-chronic-heart-failure-by-regional-washout-rate-in-cardiac-mibg-spect-imaging
#7
Hironori Yamamoto, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Yoshihiro Sato, Iyo Ikeda, Eiji Fukuhara, Makoto Abe, Jun Nakamura, Masatake Fukunami
BACKGROUND: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). METHODS: We studied 73 CHF outpatients with LVEF < 40%...
May 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28497964/biosynthetic-origin-of-the-hydroxamic-acid-moiety-of-trichostatin-a-identification-of-unprecedented-enzymatic-machinery-involved-in-hydroxylamine-transfer
#8
Kei Kudo, Taro Ozaki, Kazuo Shin-Ya, Makoto Nishiyama, Tomohisa Kuzuyama
Trichostatin A (TSA) is widely used in the field of epigenetics because it potently inhibits histone deacetylase (HDAC). In-depth studies have revealed that the hydroxamic acid group in TSA chelates the zinc(II) ion in the active site of HDAC to realize the inhibitory activity. Here we report the first identification of a complete TSA biosynthetic gene cluster from Streptomyces sp. RM72 and the heterologous production of TSA in Streptomyces albus. Biochemical analyses unambiguously demonstrate that unprecedented biosynthetic machinery catalyzes the direct transfer of hydroxylamine from a nonproteinogenic amino acid, l-glutamic acid γ-monohydroxamate, to the carboxylic acid group of trichostatic acid to form the hydroxamic acid moiety of TSA...
May 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28493080/therapeutic-action-of-honokiol-on-postoperative-ileus-via-downregulation-of-inos-gene-expression
#9
Taiki Mihara, Shoma Mikawa, Noriyuki Kaji, Mari Endo, Tetsuro Oikawa, Jan Tong-Rong, Hiroshi Ozaki, Masatoshi Hori
Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In the present study, we examined the effect of honokiol on postoperative ileus and discussed its site of action. Postoperative ileus model mice were generated by surgical intestinal manipulation...
May 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28490685/-ruptured-c2-aneurysm-of-the-internal-carotid-artery-with-ipsilateral-unruptured-giant-internal-carotid-artery-aneurysm-a-case-report
#10
Saya Ozaki, Hideo Tanaka, Shinya Fukumoto, Haruhisa Ichikawa, Shinji Onoue, Noriyuki Fumoto, Hajime Miyazaki, Kanehisa Kohno
A giant intracranial internal carotid artery(ICA)aneurysm is difficult to treat. We encountered a case with an unruptured giant intracranial ICA aneurysm with a ruptured C2 aneurysm of the ipsilateral ICA. In this case report, we describe how the treatment and review the literature. A 59-year-old man presented with sudden-onset headache and vomiting. He was diagnosed at a local neurosurgical unit as having a subarachnoid hemorrhage and admitted to our hospital. Cerebral angiogram revealed an unruptured giant ICA C3-4 aneurysm with a ruptured aneurysm of the ipsilateral ICA C2...
May 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28488956/introduction-of-thromboelastometry-guided-administration-of-fresh-frozen-plasma-is-associated-with-decreased-allogeneic-blood-transfusions-and-post-operative-blood-loss-in-cardiopulmonary-bypass-surgery
#11
Junko Ichikawa, Takahito Marubuchi, Keiko Nishiyama, Mitsuharu Kodaka, Klaus Görlinger, Makoto Ozaki, Makiko Komori
BACKGROUND: Cardiac surgery is frequently associated with excessive blood loss requiring multiple blood transfusions which are, in turn, associated with increased morbidity and mortality. We evaluated the effectiveness of rotational thromboelastometry (ROTEM(®))-guided administration of fresh-frozen plasma (FFP) with regards to blood loss, transfusion requirements, and major post-operative complications. MATERIALS AND METHODS: Coagulation management in 68 prospective patients undergoing cardiac surgery with cardiopulmonary bypass was based on a treatment algorithm guided by ROTEM(®) measurements...
March 23, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28485173/annals-express-reactivity-of-bilirubin-photoisomers-on-the-measurement-of-direct-bilirubin-by-the-vanadic-acid-method
#12
Hitoshi Okada, Susumu Itoh, Syohei Kawamoto, Miyo Ozaki, Takashi Kusaka
OBJECTIVE: Investigation of the reactivity of fractions of bilirubin photoisomers with the vanadic acid oxidation method. METHODS: Bilirubin photoisomers were prepared by irradiating a bilirubin/human serum albumin solution with blue light emitting diode. Direct bilirubin and bilirubin fractions were measured using the vanadic acid oxidation method and high performance liquid chromatography in the sample before and after irradiation. RESULTS: Direct bilirubin was increased in the solution containing bilirubin photoisomers...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28484157/hematopoietic-neoplasms-accompanied-by-severe-enterocolitis-due-to-aeromonas-species
#13
Yuka Miyamoto, Kengo Udaka, Etsuko Sekimoto, Hironobu Shibata, Kanako Otsuka, Keiko Mori, Toshio Shigekiyo, Shuji Ozaki
Aeromonas species are known to be a cause of diarrhea and acute enterocolitis. However, only a few cases have been reported and the pathophysiology of Aeromonas infection has not as yet been clarified. We experienced 2 cases developing severe enterocolitis during the course of hematological malignancies, specifically multiple myeloma and diffuse large B-cell lymphoma. Both patients presented with watery diarrhea that persisted for more than a week, followed by bloody diarrhea. Total colon endoscopy showed multiple ulcers on the mucosa from the sigmoid colon to the rectum, and biopsies from the ulcer revealed infiltration of neutrophils and eosinophils in the mucosa and submucosa...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28482637/inpp5d-mrna-expression-and-cognitive-decline-in-japanese-alzheimer-s-disease-subjects
#14
Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Tomoko Sao, Taku Yoshida, Takaaki Mori, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Ueno
Microglial dysfunction and inflammation have recently been shown to be related to the development of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase (INPP5D) functions broadly as a negative regulator of immune signaling, and its locus was associated with development of AD in a large-scale genome-wide association study. Thus, we examined INPP5D mRNA expression and methylation rates of the CpG sites in the upstream region of INPP5D exon 1 in peripheral leukocytes in 50 AD and age- and sex-matched control subjects...
May 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28477229/feasibility-of-the-head-mounted-display-for-ultrasound-guided-nerve-blocks-a-pilot-simulator-study
#15
Yusuke Kasuya, Shota Moriwaki, Chiaki Inano, Tomoko Fukada, Ryu Komatsu, Makoto Ozaki
The head-mounted display (HMD) has the potential to improve the quality of ultrasound-guided procedures. The aim of this non-clinical crossover designed study is to evaluate the feasibility of the HMD for ultrasound-guided nerve block. Eight experienced anesthesiologists performed ultrasound-guided peripheral nerve blocks on a training simulator with a standard approach and with an upside-down approach. Each approach was performed with a control conventional method and with an HMD. The ultrasound image and operating field were recorded by video camera...
May 5, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28475478/curiosity-about-a-positive-or-negative-event-prolongs-the-duration-of-emotional-experience
#16
Michihiro Kaneko, Yuka Ozaki, Kazuya Horike
Some researchers claim that uncertainty prolongs the duration of emotional experiences because uncertainty toward an emotion-eliciting event prolongs attention to that event. However, some results contradict this claim. We assumed that curiosity rather than uncertainty prolongs the duration of emotional experience via attention, and that attention and emotional experience are prolonged only when uncertainty elicits curiosity. This assumption is based on the information gap theory, which proposes that curiosity increases with uncertainty, but that curiosity decreases at a certain level of uncertainty...
May 5, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28468138/use-of-resorbable-fixation-system-in-pediatric-facial-fractures
#17
Frankie K Wong, Saleigh Adams, Donald A Hudson, Wayne Ozaki
INTRODUCTION: Resorbable fixation system (RFS) is an alternative to titanium in open reduction and internal fixation of pediatric facial fractures. METHODS: This study retrospectively reviewed all medical records in a major metropolitan pediatric hospital in Cape Town, South Africa from September 2010 through May 2014. Inclusion criteria were children under the age of 13 with facial fractures who have undergone open reduction and internal fixation using RFS. Intraoperative and postoperative complications were reviewed...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28463490/structural-insights-into-the-cotb2-catalyzed-cyclization-of-geranylgeranyl-diphosphate-to-the-diterpene-cyclooctat-9-en-7-ol
#18
Takeo Tomita, Seung-Young Kim, Kazuya Teramoto, Ayuko Meguro, Taro Ozaki, Ayako Yoshida, Yudai Motoyoshi, Naoki Mori, Ken Ishigami, Hidenori Watanabe, Makoto Nishiyama, Tomohisa Kuzuyama
The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond rearrangement combined with multiple hydride shifts, all occurring at a single active site. Here, we report the first high-resolution X-ray crystal structure of CotB2 with bound substrate analog geranylgeranyl thiodiphosphate (GGSPP). In the GGSPP-bound form, GGSPP folds into a unique S-shaped conformation that probably reflects the substrate-bound state prior to ionization of the substrate GGPP...
May 2, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28459706/large-intracavernous-carotid-artery-aneurysm
#19
Manabu Suzuki, Shin-Ichi Haginomori, Tetsuya Terada, Takaki Inui, Yusuke Ayani, Akiko Ozaki, Ryo Kawata, Kazuhiro Yamamoto
No abstract text is available yet for this article.
April 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28458314/early-spontaneous-remission-of-intramyocardial-dissecting-hematoma
#20
Ayako Miura, Yusuke Uemura, Kenji Takemoto, Tomohiro Uchikawa, Masayoshi Koyasu, Shinji Ishikawa, Takayuki Mitsuda, Ryo Imai, Satoshi Iwamiya, Yuta Ozaki, Takashi Watanabe, Masato Watarai, Hideki Ishii, Toyoaki Murohara
Intramyocardial dissecting hematoma is a rare but potentially fatal complication of myocardial infarction. The decision to adopt a surgical or conservative strategy may depend on the clinical and hemodynamic stability of patients. Regardless, the precise and temporal assessment of the structure of hematoma is imperative. We herein report the first case of a patient with early spontaneous remission of intramyocardial dissecting hematoma successfully managed by a conservative approach with multimodality imaging...
2017: Internal Medicine
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