keyword
MENU ▼
Read by QxMD icon Read
search

Ozaki

keyword
https://www.readbyqxmd.com/read/28098251/unsaturated-lipid-bodies-as-a-hallmark-of-inflammation-studied-by-raman-2d-and-3d-microscopy
#1
K Czamara, K Majzner, A Selmi, M Baranska, Y Ozaki, A Kaczor
Endothelial HMEC-1 cells incubated with pro-inflammatory cytokine TNF-α for 6 and 24 hours were studied as a model of inflammation using Raman imaging. Striking changes in distribution, composition and concentration of cellular lipids were observed after exposure to TNF-α compared to the control. In particular, 3D Raman imaging revealed a significant increase in the amount of lipid entities formed under inflammation. Lipid bodies were randomly distributed in the cytoplasm and two types of droplets were assembled: more saturated one, in spectral characteristics resembling phosphatidylcholine and saturated cholesteryl esters, observed also in the control, and highly unsaturated one, containing also cholesterols, being a hallmark of inflamed cells...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28092421/carfilzomib-lenalidomide-and-dexamethasone-in-patients-with-heavily-pretreated-multiple-myeloma-a-phase-1-study-in-japan
#2
Kenshi Suzuki, Masaki Ri, Takaaki Chou, Isamu Sugiura, Naoki Takezako, Kazutaka Sunami, Tadao Ishida, Tohru Izumi, Shuji Ozaki, Yoshihisa Shumiya, Kenji Ota, Shinsuke Iida
This is the first study in which the carfilzomib, lenalidomide, and dexamethasone (KRd) regimen was evaluated in heavily pretreated multiple myeloma. This study is a multicenter, open-label phase 1 study of KRd in Japanese patients with relapsed or refractory multiple myeloma (RRMM). The objectives were to evaluate the safety, tolerability, efficacy and pharmacokinetics. Carfilzomib was administrated intravenously over 10 min on days 1, 2, 8, 9, 15, and 16 of a 28-day cycle. In cycle 1, the dosage for days 1 and 2 was 20 mg/m(2) , followed by 27 mg/m(2) ...
January 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/28089556/larval-stages-of-neoplagioporus-elongatus-goto-and-ozaki-1930-opecoelidae-plagioporinae-with-notes-on-potential-second-intermediate-hosts
#3
Ayaka Yano, Misako Urabe
The morphology of sporocysts and cercariae of Neoplagioporus elongatus (Goto and Ozaki, 1930) is described for the first time. A cotylomicrocercous cercaria obtained from the sorbeoconch snail Semisulcospira nakasekoae was confirmed to be the cercaria of N. elongatus, based on the degree of sequence identity of the COI gene to that of adult worms. Freshwater annelids (oligochaetes and leeches) and some aquatic insects (odonates) were demonstrated experimentally to be potential second intermediate hosts.
January 9, 2017: Parasitology International
https://www.readbyqxmd.com/read/28087537/effects-of-lactobacillus-plantarum-oll2712-culture-conditions-on-the-anti-inflammatory-activity-for-murine-immune-cells-and-obese-and-type-2-diabetic-mice
#4
T Toshimitsu, S Ozaki, J Mochizuki, K Furuichi, Y Asami
: Studies on the health-promoting effects of lactic acid bacteria (LAB) are numerous, but few provide examples of the relationship between LAB function and culture conditions. We verified the effect of differences in culture conditions on Lactobacillus plantarum OLL2712 (OLL2712) functionality; this strain exhibits anti-inflammatory activity and preventive effects against metabolic disorders. We measured IL-10 and IL-12 production in murine immune cells treated with OLL2712 cells prepared under various culture conditions...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28087289/clinical-utility-and-functional-analysis-of-variants-in-atrial-fibrillation-associated-locus-4q25
#5
Yusuke Ebana, Kouichi Ozaki, Lian Liu, Hitoshi Hachiya, Kenzo Hirao, Mitsuaki Isobe, Michiaki Kubo, Toshihiro Tanaka, Tetsushi Furukawa
BACKGROUND: Chromosome 4q25 has been repeatedly identified as atrial fibrillation (AF)-sensitive locus in multiple genome-wide association studies (GWAS) and is considered to hold some clues to AF pathogenesis. We aimed to investigate the clinical utilities in Japanese and to unveil the function of the 4q25 locus in affecting transcription of adjacent genes. METHODS: We conducted AF GWAS in Japanese population (1382 AF cases and 1478 controls) and the replication panel (1666 AF cases and 1229 controls) with detailed clinical information which showed the acceleration of AF onset...
January 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28087216/denosumab-and-alendronate-treatment-in-patients-with-back-pain-due-to-fresh-osteoporotic-vertebral-fractures
#6
Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Yoshitaka Takei, Toshifumi Ozaki
INTRODUCTION: Denosumab specifically inhibits the receptor activator for nuclear factor-kappa B ligand (RANKL), and prevents osteoporotic fractures. Several reports have analyzed the effects of denosumab and alendronate alone on bone mineral density (BMD) or reduction of fracture risk. The objective of this study was to analyze the effects of antiresorptive osteoporosis pharmacotherapy on pain relief in patients with fresh vertebral fracture. METHODS: This retrospective, single-center study included 80 patients (10 males, 70 females) with fresh osteoporotic vertebral fractures treated using denosumab at a dose of 60 mg subcutaneously every 6 months (40 patients) or alendronate at a dose of 35 mg orally every week (40 patients) for 6 months in our hospital...
January 10, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28086993/lack-of-partial-renal-response-by-12%C3%A2-weeks-after-induction-therapy-predicts-poor-renal-response-and-systemic-damage-accrual-in-lupus-nephritis-class-iii-or-iv
#7
Hironari Hanaoka, Hidehiro Yamada, Tomofumi Kiyokawa, Harunobu Iida, Takeshi Suzuki, Yoshioki Yamasaki, Seido Ooka, Hiroko Nagafuchi, Takahiro Okazaki, Daisuke Ichikawa, Sayuri Shirai, Yugo Shibagaki, Junki Koike, Shoichi Ozaki
BACKGROUND: Lupus nephritis class III or IV is associated with a poor prognosis for both patient and renal survival. Recommendations for the management of lupus nephritis have recently been established, and changing therapies is recommended for patients who do not respond adequately to induction therapy. However, it remains a major challenge to determine when to switch the treatment. In this study, we identified early prognostic factors capable of predicting poor renal outcome as well as overall damage accrual in patients with lupus nephritis class III or IV...
January 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28086800/relevance-of-fxr-p62-sqstm1-pathway-for-survival-and-protection-of-mouse-hepatocytes-and-liver-especially-with-steatosis
#8
Sanae Haga, Yimin, Michitaka Ozaki
BACKGROUND: Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as steatosis. Therefore, protection from the injury of hepatocytes and liver is a serious concern in various clinical settings. METHODS: We studied the effects of the farnesoid X receptor (FXR) on cell survival and steatosis in mouse hepatocytes (AML12 mouse liver cells) and investigated their molecular mechanisms...
January 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28073591/neuropeptide-y-neuronal-network-dysfunction-in-the-frontal-lobe-of-a-genetic-mouse-model-of-schizophrenia
#9
Shunsuke Morosawa, Shuji Iritani, Hiroshige Fujishiro, Hirotaka Sekiguchi, Youta Torii, Chikako Habuchi, Keisuke Kuroda, Kozo Kaibuchi, Norio Ozaki
Neuropeptide Y (NPY) has been found to play a critical role in various mental functions as a neurotransmitter and is involved in the development of schizophrenia, a particularly intractable psychiatric disease whose precise etiology remains unknown. Recent molecular biological investigations have identified several candidate genes which may be associated with this disease, including disrupted-in-schizophrenia 1 (DISC1). The role of DISC1 would involve neurogenesis and neuronal migration. However, the functional consequences of this gene defect have not yet been fully clarified in neuronal systems...
January 5, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28071764/aligned-copper-nanorod-arrays-for-highly-efficient-generation-of-intense-ultra-broadband-thz-pulses
#10
S Mondal, Q Wei, W J Ding, H A Hafez, M A Fareed, A Laramée, X Ropagnol, G Zhang, S Sun, Z M Sheng, J Zhang, T Ozaki
We demonstrate an intense broadband terahertz (THz) source based on the interaction of relativistic-intensity femtosecond lasers with aligned copper nanorod array targets. For copper nanorod targets with a length of 5 μm, a maximum 13.8 times enhancement in the THz pulse energy (in ≤20 THz spectral range) is measured as compared to that with a thick plane copper target under the same laser conditions. A further increase in the nanorod length leads to a decrease in the THz pulse energy at medium frequencies (≤20 THz) and increase of the electromagnetic pulse energy in the high-frequency range (from 20-200 THz)...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070063/use-of-cuo-particles-as-an-interface-in-lc-ftir-analysis
#11
Yan Li, Ran Guo, Shengnan Liu, Anqi He, Yanan Bao, Shifu Weng, Yaping Huang, Yizhuang Xu, Yukihiro Ozaki, Isao Noda, Jinguang Wu
In this study, the feasibility of using copper oxide (CuO) as an interface for the coupling of liquid chromatography (LC) and Fourier-transform infrared (FTIR) spectroscopy was investigated. CuO exhibits low absorption in the 4000 to 1000 cm(-1) FTIR spectral region. In addition, LC-FTIR using CuO as the interface was extended to the analysis of sample mixtures containing benzamide and dioctyl sebacate; both analytes were successfully separated. After complete removal of the mobile phase, benzamide and dioctyl sebacate were successfully identified from the FTIR spectrum...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28052287/is-overnight-fasting-before-surgery-too-much-or-not-enough-how-basic-aging-research-can-guide-preoperative-nutritional-recommendations-to-improve-surgical-outcomes-a-mini-review
#12
Alban Longchamp, Eylul Harputlugil, Jean-Marc Corpataux, C Keith Ozaki, James R Mitchell
Dietary restriction (DR) is best known for extending lifespan in experimental model organisms, but also increases resistance to a variety of clinically relevant stressors, including those associated with surgery. Extended periods of DR, lasting months to years, are required for optimal longevity benefits in rodents, but short-term dietary preconditioning (less than 1 week) remarkably protects from acute injury. Here, we discuss recent advances in our understanding of the mechanistic basis of short-term DR and fasting in the context of surgical stress resistance, including upstream amino acid sensing by the GCN2 and mTORC1 pathways, and downstream effector mechanisms including increased insulin-dependent prosurvival signaling and elevated endogenous hydrogen sulfide production...
January 5, 2017: Gerontology
https://www.readbyqxmd.com/read/28050748/development-of-diagnostic-techniques-for-early-rheumatoid-arthritis-using-positron-emission-tomography-with-11-c-pk11195-and-11-c-ketoprofen-tracers
#13
Satoshi Nozaki, Naoko Ozaki, Shinobu Suzuki, Miki Goto, Aya Mawatari, Yuka Nakatani, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe
PURPOSE: In vivo detection of pathological insults during the early stages of rheumatoid synovitis is essential to allow early anti-inflammatory treatment for prevention of joint destruction. Whether rheumatoid synovitis pathology and the efficacy of therapies can be visualized by positron emission tomography (PET) tracers specific to the inflammatory process was investigated. PROCEDURES: Using a collagen-induced experimental rat model of rheumatoid arthritis, in vivo imaging using the PET tracers [(11)C]PK11195, which binds to the translocator protein mainly expressed on myeloid cells, and [(11)C]ketoprofen, for cyclooxygenase imaging, was performed...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28038708/usefulness-of-p16-cdkn2a-fluorescence-in-situ-hybridization-and-bap1-immunohistochemistry-for-the-diagnosis-of-biphasic-mesothelioma
#14
Di Wu, Kenzo Hiroshima, Toshikazu Yusa, Daisuke Ozaki, Eitetsu Koh, Yasuo Sekine, Shinji Matsumoto, Kazuki Nabeshima, Ayuko Sato, Tohru Tsujimura, Hisami Yamakawa, Yuji Tada, Hideaki Shimada, Masatoshi Tagawa
Malignant mesothelioma is a highly aggressive neoplasm, and the histologic subtype is one of the most reliable prognostic factors. Some biphasic mesotheliomas are difficult to distinguish from epithelioid mesotheliomas with atypical fibrous stroma. The aim of this study was to analyze p16/CDKN2A deletions in mesotheliomas by fluorescence in situ hybridization (FISH) and BAP1 immunohistochemistry to evaluate their potential role in the diagnosis of biphasic mesothelioma. We collected 38 cases of pleural mesotheliomas...
February 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28028907/clec-2-promotes-hematogenous-tumor-metastasis-and-prothrombotic-state-in-tumor-bearing-mice
#15
Toshiaki Shirai, Osamu Inoue, Shogo Tamura, Nagaharu Tsukiji, Tomoyuki Sasaki, Hiroshi Endo, Kaneo Satoh, Makoto Osada, Hitomi Sato-Uchida, Hideki Fujii, Yukio Ozaki, Katsue Suzuki-Inoue
BACKGROUND: C-type lectin-like receptor 2 (CLEC-2) is a platelet activation receptor of sialoglycoprotein podoplanin, which is expressed on the surface of certain types of tumor cells. CLEC-2-podoplanin interactions facilitate hematogenous tumor metastasis. However, direct evidence of the role of CLEC-2 in hematogenous metastasis and cancer progression is lacking. OBJECTIVE AND METHODS: We generated immunological CLEC-2-depleted mice by using anti-mouse CLEC-2 monoclonal antibody 2A2B10 and investigated whether CLEC-2 promoted hematogenous tumor metastasis and tumor growth and exacerbated the prognosis of mice bearing podoplanin-expressing B16F10 melanoma cells...
December 27, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28028647/accuracy-of-pedicle-screw-insertion-in-posterior-scoliosis-surgery-a-comparison-between-intraoperative-navigation-and-preoperative-navigation-techniques
#16
Wei Zhang, Tomoyuki Takigawa, YongGang Wu, Yoshihisa Sugimoto, Masato Tanaka, Toshifumi Ozaki
PURPOSE: This study was conducted to compare the efficacy and accuracy of intraoperative navigation (O-arm or Arcadis navigation) and preoperative CT-based navigation in adolescent idiopathic scoliosis (AIS) surgery. METHODS: Sixty-seven patients with scoliosis were grouped according to the method of navigation used in their fixation surgeries. A total of 492 pedicle screws were implanted in 27 patients using intraoperative navigation, and 626 screws were implanted in 40 patients using preoperative navigation...
December 27, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28025457/interlaboratory-study-on-caprolactam-test-for-food-contact-nylon-products
#17
Kazunari Watanabe, Motoh Mutsuga, Takashi Abe, Tomoyuki Abe, Yutaka Abe, Ikue Ohsaka, Haruka Ohno, Hiroyuki Ohno, Yuichiro Ohno, Asako Ozaki, Yoshiteru Kakihara, Hisashi Kobayashi, Takahide Kondo, Hiroshi Shibata, Katsuhiro Shirono, Haruko Sekido, Hironori Sonobe, Noriko Takasaka, Yoshiyasu Tajima, Aoi Tanaka, Hideyuki Tanaka, Toru Nakanishi, Chie Nomura, Nahoko Haneishi, Masato Hayakawa, Akinori Hikida, Toshihiko Miura, Miku Yamaguchi, Kyoko Sato, Hiroshi Akiyama
The Japanese Food Sanitation Law sets a limit on the migration level of caprolactam for food-contacting nylon products. Here, we carried out an interlaboratory study in twenty laboratories to evaluate the performance of the official GC-FID test method and a GC-MS method as an alternative test method to the official method. Each laboratory quantified caprolactam in three test solutions in 20% ethanol as blind duplicates using GC-FID or GC-MS. The official method (GC-FID with absolute calibration) gave trueness, repeatability (RSDr) and reproducibility (RSDr) values of 96-97%, 3...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28010860/invited-commentary
#18
C Keith Ozaki
No abstract text is available yet for this article.
January 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28009559/coherent-x-ray-beam-metrology-using-2d-high-resolution-fresnel-diffraction-analysis
#19
M Ruiz-Lopez, A Faenov, T Pikuz, N Ozaki, A Mitrofanov, B Albertazzi, N Hartley, T Matsuoka, Y Ochante, Y Tange, T Yabuuchi, T Habara, K A Tanaka, Y Inubushi, M Yabashi, M Nishikino, T Kawachi, S Pikuz, T Ishikawa, R Kodama, D Bleiner
Direct metrology of coherent short-wavelength beamlines is important for obtaining operational beam characteristics at the experimental site. However, since beam-time limitation imposes fast metrology procedures, a multi-parametric metrology from as low as a single shot is desirable. Here a two-dimensional (2D) procedure based on high-resolution Fresnel diffraction analysis is discussed and applied, which allowed an efficient and detailed beamline characterization at the SACLA XFEL. So far, the potential of Fresnel diffraction for beamline metrology has not been fully exploited because its high-frequency fringes could be only partly resolved with ordinary pixel-limited detectors...
January 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28008202/investigation-of-single-nucleotide-variants-in-mbd5-associated-with-autism-spectrum-disorders-and-schizophrenia-phenotypes
#20
Kanako Ishizuka, Hiroki Kimura, Akira Yoshimi, Masahiro Banno, Itaru Kushima, Yota Uno, Takashi Okada, Daisuke Mori, Branko Aleksic, Norio Ozaki
MBD5 (Methyl-CpG-binding domain 5) is a critical gene for normal development. While deletion or duplication of MBD5 may contribute to a genetic predisposition to autism spectrum disorders (ASD), intellectual disability, or epilepsy, the impact of rare MBD5 single nucleotide variants (SNVs) on neurodevelopmental features, particularly features with late onset, has not been fully explored. In this study, we conducted exon-targeted resequencing of MBD5 with next-generation sequencing technology in 562 Japanese patients (192 with idiopathic ASD and 370 with schizophrenia (SCZ)) and detected 16 MBD5 SNVs with allele frequencies of ≤1%...
December 2016: Nagoya Journal of Medical Science
keyword
keyword
62626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"