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https://www.readbyqxmd.com/read/28637225/characteristics-of-escherichia-coli-isolated-from-broiler-chickens-with-colibacillosis-in-commercial-farms-from-a-common-hatchery
#1
H Ozaki, Y Matsuoka, E Nakagawa, T Murase
To investigate the epidemiologic aspects of colibacillosis in broiler chickens, 83 Escherichia coli isolates obtained from the pericarditis and perihepatitis lesions in broiler chickens from 4 commercial farms, 5 isolates recovered from 5 samples of yolk sac contents that were pooled from 25 emaciated chicks, and 4 fecal isolates obtained from a hatchery that supplied chicks to the 4 commercial farms mentioned above were genetically and bacteriologically characterized. Using pulsed-field gel electrophoresis (PFGE), a total of 92 isolates were classified into 33 pulsotypes...
June 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28632054/middle-finger-and-ball-movements-around-ball-release-during-baseball-fastball-pitching
#2
Tomoyuki Matsuo, Tsutomu Jinji, Daisaku Hirayama, Daiki Nasu, Hiroki Ozaki, Daisuke Kumagawa
The objectives of this study were to investigate middle finger movements and dynamics of ball movements around the instant of ball release during baseball pitching. Baseball pitching from an indoor mound among 14 semi-professional pitchers was captured using a motion capture system with 16 high-speed cameras (1,000 Hz). Kinematics of middle finger joints, ball rotation, and force applied to the ball were calculated. The proximal and distal interphalangeal joints continued to extend until the instant of ball release, then abruptly flexed...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28630909/dynamic-fracture-of-tantalum-under-extreme-tensile-stress
#3
Bruno Albertazzi, Norimasa Ozaki, Vasily Zhakhovsky, Anatoly Faenov, Hideaki Habara, Marion Harmand, Nicholas Hartley, Denis Ilnitsky, Nail Inogamov, Yuichi Inubushi, Tetsuya Ishikawa, Tetsuo Katayama, Takahisa Koyama, Michel Koenig, Andrew Krygier, Takeshi Matsuoka, Satoshi Matsuyama, Emma McBride, Kirill Petrovich Migdal, Guillaume Morard, Haruhiko Ohashi, Takuo Okuchi, Tatiana Pikuz, Narangoo Purevjav, Osami Sakata, Yasuhisa Sano, Tomoko Sato, Toshimori Sekine, Yusuke Seto, Kenjiro Takahashi, Kazuo Tanaka, Yoshinori Tange, Tadashi Togashi, Kensuke Tono, Yuhei Umeda, Tommaso Vinci, Makina Yabashi, Toshinori Yabuuchi, Kazuto Yamauchi, Hirokatsu Yumoto, Ryosuke Kodama
The understanding of fracture phenomena of a material at extremely high strain rates is a key issue for a wide variety of scientific research ranging from applied science and technological developments to fundamental science such as laser-matter interaction and geology. Despite its interest, its study relies on a fine multiscale description, in between the atomic scale and macroscopic processes, so far only achievable by large-scale atomic simulations. Direct ultrafast real-time monitoring of dynamic fracture (spallation) at the atomic lattice scale with picosecond time resolution was beyond the reach of experimental techniques...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28630586/surveillance-efforts-after-mass-drug-administration-to-validate-elimination-of-lymphatic-filariasis-as-a-public-health-problem-in-vanuatu
#4
Fasihah Taleo, George Taleo, Patricia M Graves, Peter Wood, Sung Hye Kim, Masayo Ozaki, Hayley Joseph, Brian Chu, Alex Pavluck, Aya Yajima, Wayne Melrose, Kazuyo Ichimori, Corinne Capuano
BACKGROUND: Vanuatu was formerly highly endemic for lymphatic filariasis (LF), caused by Wuchereria bancrofti and transmitted by Anopheles mosquitoes. After a baseline survey showing 4.8% antigen prevalence in 1998, the country conducted nationwide (in one implementation unit) annual mass drug administration (MDA) with albendazole and diethylcarbamazine citrate from 2000 to 2004 and achieved prevalence of 0.2% by 2006 in a representative nationwide cluster survey among all age groups...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28629330/breast-cancer-patient-delay-in-fukushima-japan-following-the-2011-triple-disaster-a-long-term-retrospective-study
#5
Akihiko Ozaki, Shuhei Nomura, Claire Leppold, Masaharu Tsubokura, Tetsuya Tanimoto, Takeru Yokota, Shigehira Saji, Toyoaki Sawano, Manabu Tsukada, Tomohiro Morita, Sae Ochi, Shigeaki Kato, Masahiro Kami, Tsuyoshi Nemoto, Yukio Kanazawa, Hiromichi Ohira
BACKGROUND: Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple disaster in Fukushima, Japan, and to elucidate factors associated with post-disaster patient delay. Sociodemographic factors (age, employment status, cohabitant status and evacuation status), health characteristics, and health access- and disaster-related factors were specifically considered...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28628214/unconventional-role-of-voltage-gated-proton-channels-vsop-hv1-in-regulation-of-microglial-ros-production
#6
Takafumi Kawai, Yoshifumi Okochi, Tomohiko Ozaki, Yoshio Imura, Schuichi Koizumi, Maya Yamazaki, Manabu Abe, Kenji Sakimura, Toshihide Yamashita, Yasushi Okamura
It has been established that voltage-gated proton channels (VSOP/Hv1), encoded by Hvcn1, support reactive oxygen species (ROS) production in phagocytic activities of neutrophils (El Chemaly et al. 2010) and antibody production in B lymphocytes (Capasso et al. 2010). VSOP/Hv1 is a potential therapeutic target for brain ischemia, since Hvcn1 deficiency reduces microglial ROS production and protects brain from neuronal damage (Wu et al. 2012). In the present study, we report that VSOP/Hv1 has paradoxical suppressive role in ROS production in microglia...
June 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28623954/efficacy-and-safety-of-alirocumab-in-patients-with-hypercholesterolemia-not-adequately-controlled-with-non-statin-lipid-lowering-therapy-or-the-lowest-strength-of-statin-odyssey-nippon-study-design-and-rationale
#7
Tamio Teramoto, Akira Kondo, Arihiro Kiyosue, Mariko Harada-Shiba, Yasushi Ishigaki, Kimimasa Tobita, Yumiko Kawabata, Asuka Ozaki, Marie T Baccara-Dinet, Masataka Sata
BACKGROUND: Statins are generally well-tolerated and serious side effects are infrequent, but some patients experience adverse events and reduce their statin dose or discontinue treatment altogether. Alirocumab is a highly specific, fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), which can produce substantial and sustained reductions of low-density lipoprotein cholesterol (LDL-C). METHODS: The randomized, double-blind, placebo-controlled, parallel-group, phase 3 ODYSSEY NIPPON study will explore alirocumab 150 mg every 4 weeks (Q4W) in 163 Japanese patients with hypercholesterolemia who are on the lowest-strength dose of atorvastatin (5 mg/day) or are receiving a non-statin lipid-lowering therapy (LLT) (fenofibrate, bezafibrate, ezetimibe, or diet therapy alone)...
June 17, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28622208/duloxetine-plasma-concentrations-and-its-effectiveness-in-the-treatment-of-nonorganic-chronic-pain-in-the-orofacial-region
#8
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
OBJECTIVE: The purpose of this study was to examine the relationship between the pain-relieving effects of duloxetine and its plasma concentrations in patients with burning mouth syndrome and atypical odontalgia characterized by chronic nonorganic pain in the orofacial region. METHODS: We administered duloxetine to 77 patients diagnosed as having burning mouth syndrome or atypical odontalgia for 12 weeks. The initial dose of duloxetine was established as 20 mg/d and was increased to 40 mg/d after week 2...
June 16, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28620163/natural-history-of-relapsed-myeloma-refractory-to-immunomodulatory-drugs-and-proteasome-inhibitors-a-multicenter-imwg-study
#9
S K Kumar, M A Dimopoulos, E Kastritis, E Terpos, H Nahi, H Goldschmidt, J Hillengass, X Leleu, M Beksac, M Alsina, A Oriol, M Cavo, E M Ocio, M V Mateos, E K O'Donnell, R Vij, H M Lokhorst, N W C J van de Donk, C Min, T Mark, I Turesson, M Hansson, H Ludwig, S Jagannath, M Delforge, C Kyriakou, P Hari, U Mellqvist, S Z Usmani, D Dytfeld, A Z Badros, P Moreau, K Kim, P R Otero, J H Lee, C Shustik, D Waller, W J Chng, S Ozaki, J-J Lee, J de la Rubia, H S Eom, L Rosinol, J J Lahuerta, A Sureda, J S Kim, B G M Durie
Introduction of new myeloma therapies offers new options for patients refractory to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). In this multicenter study, patients with relapsed multiple myeloma, who have received at least three prior lines of therapy, are refractory to both an IMiD (lenalidomide or pomalidomide) and a PI (bortezomib or carfilzomib), and have been exposed to an alkylating agent were identified. The time patients met the above criteria was defined as time zero (T0). Five hundred and forty-three patients diagnosed between 2006 and 2014 were enrolled in this study...
May 12, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28611924/pcs-mva-syndrome-caused-by-an-alu-insertion-in-the-bub1b-gene
#10
Maki Kato, Takema Kato, Eriko Hosoba, Masanao Ohashi, Midori Fujisaki, Mamoru Ozaki, Masatoshi Yamaguchi, Hiroshi Sameshima, Hiroki Kurahashi
We report a case of premature chromatid separation/mosaic variegated aneuploidy syndrome identified by microcephaly on fetal ultrasound and confirmed by cytogenetic analysis of amniotic fluid. Initial mutational analysis of the entire coding region of the BUB1B gene failed to identify any causative mutations. However, further analysis revealed a known compound heterozygous mutation in the upstream region of this gene and a novel Alu insertion mutation in the intron.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28602632/brachial-ankle-pulse-wave-velocity-as-a-predictor-of-silent-cerebral-embolism-after-carotid-artery-stenting
#11
Tomoaki Murakami, Hajime Nakamura, Takeo Nishida, Tomohiko Ozaki, Katsunori Asai, Tomoki Kidani, Yoshinori Kadono, Manabu Sakaguchi, Toshiki Yoshimine, Haruhiko Kishima
BACKGROUND: In neuroendovascular therapy, the effect of arterial stiffness on postprocedural cerebral thromboembolism is unknown. In this observational study, we examined the relationship between cerebral thromboembolism after carotid artery stenting and arterial stiffness. METHODS: From April 2015 to February 2017, we enrolled consecutive patients undergoing scheduled carotid artery stenting in our institution. In all patients, preprocedural brachial-ankle pulse wave velocity was used to assess arterial stiffness, whereas the number of new cerebral ischemic lesions on diffusion-weighted magnetic resonance imaging was assessed after treatment...
June 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28601038/investigation-on-intermolecular-interaction-between-berberine-and-%C3%AE-cyclodextrin-by-2d-uv-vis-asynchronous-spectra
#12
Anqi He, Xiaoyan Kang, Yizhuang Xu, Isao Noda, Yukihiro Ozaki, Jinguang Wu
The interaction between berberine chloride and β-cyclodextrin (β-CyD) is investigated via 2D asynchronous UV-Vis spectrum. The occurrence of cross peaks around (420nm, 420nm) in 2D asynchronous spectrum reveals that specific intermolecular interaction indeed exists between berberine chloride and β-CyD. In spite of the difficulty caused by overlapping of cross peaks, we manage to confirm that the 420nm band of berberine undergoes a red-shift, and its bandwidth decreases under the interaction with β-CyD. The red-shift of the 420nm band that can be assigned to n-π* transition indicates the environment of berberine becomes more hydrophobic...
June 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28597806/sinonasal-organised-haematoma-clinical-features-and-successful-application-of-modified-transnasal-endoscopic-medial-maxillectomy
#13
M Suzuki, Y Nakamura, S Ozaki, M Yokota, S Murakami
OBJECTIVE: Although organised haematoma often induces bone thinning and destruction similar to malignant diseases, the aetiology of organised haematoma and the optimal treatment remain unclear. This paper presents the clinical features of individuals with organised haematoma, and describes cases in which a novel modified approach was successfully applied for resection of organised haematoma in the maxillary sinus. METHOD: Pre-operative examination data were evaluated retrospectively...
June 9, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28591845/severe-esophagitis-associated-with-cytomegalovirus-during-concurrent-chemoradiotherapy-for-esophageal-cancer
#14
Rihito Aizawa, Shigemi Matsumoto, Yu Uneno, Yoshitaka Nishikawa, Yoshinao Ozaki, Yukiko Mori, Masashi Kanai, Yuichi Ishida, Katsuyuki Sakanaka, Masahiro Hiraoka, Manabu Muto
Although radiation esophagitis is one of the most common adverse events that occurs during chemoradiotherapy (CRT) in patients with esophageal cancer, CRT-associated cytomegalovirus (CMV) esophagitis is rare. CMV esophagitis typically occurs in patients with an immunosuppressed status. Here we report a case of CMV esophagitis during CRT initially treated as radiation esophagitis. A 64-year-old man with mid-thoracic esophageal cancer was admitted to our hospital with clinical stage cT4bN1M1 (supraclavicular lymph node metastasis) Stage IV according to the UICC ver...
June 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28591635/hypothalamic-pituitary-axis-regulates-hydrogen-sulfide-production
#15
Christopher Hine, Hyo-Jeong Kim, Yan Zhu, Eylul Harputlugil, Alban Longchamp, Marina Souza Matos, Preeti Ramadoss, Kevin Bauerle, Lear Brace, John M Asara, C Keith Ozaki, Sheue-Yann Cheng, Subhankar Singha, Kyo Han Ahn, Alec Kimmelman, Ffolliott M Fisher, Pavlos Pissios, Dominic J Withers, Colin Selman, Rui Wang, Kelvin Yen, Valter D Longo, Pinchas Cohen, Andrzej Bartke, John J Kopchick, Richard Miller, Anthony N Hollenberg, James R Mitchell
Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (H2S) is increased upon DR and plays an essential role in mediating DR benefits across evolutionary boundaries. Here we found increased hepatic H2S production in long-lived mouse strains of reduced GH and/or TH action, and in a cell-autonomous manner upon serum withdrawal in vitro...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28589958/astronomical-pacing-of-the-global-silica-cycle-recorded-in-mesozoic-bedded-cherts
#16
Masayuki Ikeda, Ryuji Tada, Kazumi Ozaki
The global silica cycle is an important component of the long-term climate system, yet its controlling factors are largely uncertain due to poorly constrained proxy records. Here we present a ∼70 Myr-long record of early Mesozoic biogenic silica (BSi) flux from radiolarian chert in Japan. Average low-mid-latitude BSi burial flux in the superocean Panthalassa is ∼90% of that of the modern global ocean and relative amplitude varied by ∼20-50% over the 100 kyr to 30 Myr orbital cycles during the early Mesozoic...
June 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28589052/safe-and-effective-reduction-technique-for-intertrochanteric-fracture-with-ipsilateral-below-knee-amputated-limb
#17
Hironori Ochi, Tomonori Baba, Takahiro Hamanaka, Yu Ozaki, Taiji Watari, Yasuhiro Homma, Mikio Matsumoto, Kazuo Kaneko
The positioning of the patient on the fracture table is critical for the successful reduction and operative fixation of intertrochanteric hip fractures. However, this manipulation is challenging with patients who have undergone amputations of their legs. A 97-year-old man presented to the emergency department with symptom of right hip pain following a mechanical fall. He had a below-knee amputation on his right leg following a traffic accident as a 19-year-old and had a below-knee patellar tendon bearing prosthesis fitted to his lower limb for mobility...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28588439/dna-methylation-changes-in-intron-1-of-triggering-receptor-expressed-on-myeloid-cell-2-in-japanese-schizophrenia-subjects
#18
Yuta Yoshino, Yuki Ozaki, Kiyohiro Yamazaki, Tomoko Sao, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Ueno
A hypothesis for schizophrenia (SCZ) called the "microglia hypothesis" has been suggested. In SCZ, expression of triggering receptor expressed on myeloid cell 2 (TREM2) mRNA is higher in leukocytes than in healthy individuals. Here, the methylation rates of four CpG sites in TREM2 intron 1 that may bind important transcription factors and the correlation between the methylation rate and mRNA expression were determined. We compared the methylation rates in SCZ patients and age-matched controls (n = 50 each)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28587749/pluripotent-stem-cell-models-of-blau-syndrome-reveal-an-ifn-%C3%AE-dependent-inflammatory-response-in-macrophages
#19
Sanami Takada, Naotomo Kambe, Yuri Kawasaki, Akira Niwa, Fumiko Honda-Ozaki, Kazuki Kobayashi, Mitsujiro Osawa, Ayako Nagahashi, Katsunori Semi, Akitsu Hotta, Isao Asaka, Yasuhiro Yamada, Ryuta Nishikomori, Toshio Heike, Hiroyuki Matsue, Tatsutoshi Nakahata, Megumu K Saito
BACKGROUND: Blau syndrome, or early-onset sarcoidosis, is a juvenile-onset systemic granulomatosis associated with a mutation in nucleotide-binding oligomerization domain 2 (NOD2). The underlying mechanisms of Blau syndrome leading to autoinflammation are still unclear, and there is currently no effective specific treatment for Blau syndrome. OBJECTIVES: To elucidate the mechanisms of autoinflammation in patients with Blau syndrome, we sought to clarify the relation between disease-associated mutant NOD2 and the inflammatory response in human samples...
June 3, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28585773/electro-activated-conductivity-and-white-light-emission-of-a-hydrocarbon-nanoring-iodine-assembly
#20
Noriaki Ozaki, Hirotoshi Sakamoto, Taishi Nishihara, Toshihiko Fujimori, Yuh Hijikata, Ryuto Kimura, Stephan Irle, Kenichiro Itami
We report an electric-stimuli-responsive multifunctional material that can be readily made by simply mixing a hydrocarbon nanoring ([10]cycloparaphenylene: [10]CPP) and iodine ([10]CPP-I). Through applying electric stimulus, the assembled material [10]CPP-I is endowed with two attractive properties: turn-on electronic conductivity and white light emission. We determined that electric stimuli trigger the cascade formation of polyiodide chains inside the [10]CPP assembly through charge transfer, leading to the emergence of these fascinating properties...
June 6, 2017: Angewandte Chemie
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