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https://www.readbyqxmd.com/read/29771235/bordetella-pertussis-population-dynamics-and-phylogeny-in-japan-after-adoption-of-acellular-pertussis-vaccines
#1
Aldert Zomer, Nao Otsuka, Yukihiro Hiramatsu, Kazunari Kamachi, Naoko Nishimura, Takao Ozaki, Jan Poolman, Jeroen Geurtsen
Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here, we performed whole genome sequencing analysis of 149 clinical strains, provided by the National Institute of Infectious Diseases (NIID), Japan, isolated in 1982-2014, after Japan became the first country to adopt acellular vaccines against B. pertussis. Additionally, we sequenced 39 strains provided by the Konan Kosei Hospital in Aichi prefecture, Japan, isolated in 2008-2013...
May 17, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29770290/current-surgical-strategies-and-techniques-of-aortic-valve-diseases-in-children
#2
REVIEW
Kun Wang, Huifeng Zhang, Bing Jia
While the long-term outcome of surgical aortic valvotomy (SAV) appears to be better than that of balloon aortic valvuloplasty (BAV) as the primary procedure of aortic valve stenosis, the surgical strategies and techniques of treating aortic valve disease in children in other situations remain controversial. Valve repair should be first considered while replacement is still unavoidable in some cases, and new repair techniques developed by innovative surgeons are gradually becoming adopted. Some complex repair procedures such as cusp extension, leaflet replacement/reconstruction have provided satisfactory outcomes...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29766378/2-methacryloyloxyethyl-phosphorylcholine-mpc-polymer-suppresses-an-increase-of-oral-bacteria-a-single-blind-crossover-clinical-trial
#3
Natsumi Fujiwara, Hiromichi Yumoto, Koji Miyamoto, Katsuhiko Hirota, Hiromi Nakae, Saya Tanaka, Keiji Murakami, Yasusei Kudo, Kazumi Ozaki, Yoichiro Miyake
OBJECTIVES: The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. The aim of this study is to clarify whether MPC-polymer can suppress the bacterial adherence in oral cavity by a crossover design. We also investigated the number of Fusobacterium nucleatum, which is the key bacterium forming dental plaque, in clinical samples. MATERIALS AND METHODS: This study was a randomized, placebo-controlled, single-blind, crossover study, with two treatment periods separated by a 2-week washout period...
May 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29760308/cardiovascular-outcome-and-mortality-in-patients-undergoing-endovascular-treatment-for-symptomatic-peripheral-artery-disease-short-term-results-of-the-toma-code-registry
#4
Michiaki Higashitani, Yukari Uemura, Atsushi Mizuno, Makoto Utsunomiya, Tetsuo Yamaguchi, Akihiro Matsui, Shunsuke Ozaki, Kazuki Tobita, Atsushi Tosaka, Akitsugu Oida, Kenji Suzuki, Takahide Kodama, Kentaro Jujo, Tatsuki Doijiri, Yasuhiro Takahashi, Shunsuke Matsuno, Nobuhito Kaneko, Akira Moriguchi, Shohei Kishi, Hitoshi Anzai
BACKGROUND: The present study was performed to clarify whether the preoperative clinical symptoms for endovascular therapy (EVT) can predict post-EVT death and cardiovascular prognosis in Japanese patients with peripheral artery disease (PAD), including acute disease.Methods and Results:The TOkyo taMA peripheral vascular intervention research COmraDE (Toma-Code) Registry is a Japanese prospective cohort of 2,321 consecutive patients with PAD treated with EVT, in 34 hospitals in the Kanto and Kōshin'etsu regions, from August 2014 to August 2016...
May 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29750001/effect-of-combined-dyslipidemia-and-hyperglycemia-on-diabetic-peripheral-neuropathy-in-alloxan-induced-diabetic-wbn-kob-rats
#5
Kiyokazu Ozaki, Yui Terayama, Tetsuro Matsuura, Isao Narama
Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF)...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29743470/-interlaboratory-study-on-evaporation-residue-test-for-food-contact-products-report-2
#6
Hiroyuki Ohno, Motoh Mutsuga, Tomoyuki Abe, Yutaka Abe, Homare Amano, Kinuyo Ishihara, Ikue Ohsaka, Haruka Ohno, Yuichiro Ohno, Asako Ozaki, Yoshiteru Kakihara, Hisashi Kobayashi, Hiroshi Sakuragi, Hiroshi Shibata, Katsuhiro Shirono, Haruko Sekido, Noriko Takasaka, Yu Takenaka, Yoshiyasu Tajima, Aoi Tanaka, Hideyuki Tanaka, Toru Nakanishi, Chie Nomura, Nahoko Haneishi, Masato Hayakawa, Toshihiko Miura, Miku Yamaguchi, Kyohei Yamada, Kazunari Watanabe, Kyoko Sato
An interlaboratory study was performed to evaluate the equivalence between an official method and a modified method of evaporation residue test using heptane as a food-simulating solvent for oily or fatty foods, based on the Japanese Food Sanitation Law for food contact products. Twenty-three laboratories participated, and tested the evaporation residues of nine test solutions as blind duplicates. In the official method, heating for evaporation was done with a water bath. In the modified method, a hot plate was used for evaporation, and/or a vacuum concentration procedure was skipped...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29743469/-interlaboratory-study-on-evaporation-residue-test-for-food-contact-products-report-1
#7
Hiroyuki Ohno, Motoh Mutsuga, Tomoyuki Abe, Yutaka Abe, Homare Amano, Kinuyo Ishihara, Ikue Ohsaka, Haruka Ohno, Yuichiro Ohno, Asako Ozaki, Yoshiteru Kakihara, Hisashi Kobayashi, Hiroshi Sakuragi, Hiroshi Shibata, Katsuhiro Shirono, Haruko Sekido, Noriko Takasaka, Yu Takenaka, Yoshiyasu Tajima, Aoi Tanaka, Hideyuki Tanaka, Hiroyuki Tonooka, Toru Nakanishi, Chie Nomura, Nahoko Haneishi, Masato Hayakawa, Toshihiko Miura, Miku Yamaguchi, Kazunari Watanabe, Kyoko Sato
An interlaboratory study was performed to evaluate the equivalence between an official method and a modified method of evaporation residue test using three food-simulating solvents (water, 4% acetic acid and 20% ethanol), based on the Japanese Food Sanitation Law for food contact products. Twenty-three laboratories participated, and tested the evaporation residues of nine test solutions as blind duplicates. For evaporation, a water bath was used in the official method, and a hot plate in the modified method...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29743388/ultra-high-resolution-computed-tomography-angiography-for-assessment-of-coronary-artery-stenosis
#8
Sadako Motoyama, Hajime Ito, Masayoshi Sarai, Yasuomi Nagahara, Keiichi Miyajima, Ryota Matsumoto, Yujiro Doi, Yumi Kataoka, Hiroshi Takahashi, Yukio Ozaki, Hiroshi Toyama, Kazuhiro Katada
BACKGROUND: Limitations of coronary computed tomography (CTA) include false-positive stenosis at calcified lesions and assessment of in-stent patency. A prototype of ultra-high resolution computed tomography (U-HRCT: 1,792 channels and 0.25-mm slice thickness×128 rows) with improved spatial resolution was developed. We assessed the diagnostic accuracy of coronary artery stenosis using U-HRCT.Methods and Results:Seventy-nine consecutive patients who underwent CTA using U-HRCT were prospectively included...
May 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#9
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29735300/clinical-factor-associated-with-congenital-cytomegalovirus-infection-in-pregnant-women-with-non-primary-infection
#10
Hideto Yamada, Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Masashi Deguchi, Mayumi Morizane, Satoshi Nagamata, Kana Ozaki, Yasuhiko Ebina, Toshio Minematsu
The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection...
May 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29731430/pluripotent-stem-cell-model-of-nakajo-nishimura-syndrome-untangles-proinflammatory-pathways-mediated-by-oxidative-stress
#11
Fumiko Honda-Ozaki, Madoka Terashima, Akira Niwa, Norikazu Saiki, Yuri Kawasaki, Haruna Ito, Akitsu Hotta, Ayako Nagahashi, Koichi Igura, Isao Asaka, Hongmei Lisa Li, Masakatsu Yanagimachi, Fukumi Furukawa, Nobuo Kanazawa, Tatsutoshi Nakahata, Megumu K Saito
Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of the PSMB8 gene. Although dysfunction of the immunoproteasome causes various cellular stresses attributed to the overproduction of inflammatory cytokines and chemokines in NNS, the underlying mechanisms of the autoinflammation are still largely unknown. To investigate and understand the mechanisms and signal pathways in NNS, we established a panel of isogenic pluripotent stem cell (PSC) lines with PSMB8 mutation...
May 1, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29723256/renal-protective-effect-of-antiplatelet-therapy-in-antiphospholipid-antibody-positive-lupus-nephritis-patients-without-antiphospholipid-syndrome
#12
Hironari Hanaoka, Harunobu Iida, Tomofumi Kiyokawa, Yukiko Takakuwa, Takahiro Okazaki, Hidehiro Yamada, Shoichi Ozaki, Kimito Kawahata
OBJECTIVE: We sought to evaluate the effect of antiplatelet therapy in addition to conventional immunosuppressive therapy for lupus nephritis (LN) patients positive for antiphospholipid antibodies (aPL) without definite antiphospholipid syndrome (APS). METHODS: Patients with biopsy-proven LN class III or IV were retrospectively evaluated. We selected patients positive for anticardiolipin antibody (aCL) or lupus anticoagulant (LA) who did not meet the criteria for a diagnosis of APS...
2018: PloS One
https://www.readbyqxmd.com/read/29718548/heterologous-biosynthesis-of-fungal-indole-sesquiterpene-sespendole
#13
Kosei Kudo, Chengwei Liu, Tomoyuki Matsumoto, Atsushi Minami, Taro Ozaki, Hiroaki Toshima, Katsuya Gomi, Hideaki Oikawa
Indole sesquiterpene sespendole, isolated from filamentous fungus Pseudobotrytis terrestris FKA-25, is a specific inhibitor of lipid droplet synthesis in mouse macrophages. The biosynthetic pathway that involves genes encoding six enzymes (spdEMBQHJ) was elucidated through heterologous expression of spd genes in Aspergillus oryzae, biotransformation experiments, and in vitro enzymatic reactions with a recombinant protein, thereby revealing the mechanism underlying the characteristic modification on the indole ring, catalyzed by a set of prenyltransferase (SpdE)/cytochrome P450 (SpdJ) enzymes...
May 2, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29718414/a-simple-1-day-colon-capsule-endoscopy-procedure-demonstrated-to-be-a-highly-acceptable-monitoring-tool-for-ulcerative-colitis
#14
Shinji Okabayashi, Taku Kobayashi, Masaru Nakano, Takahiko Toyonaga, Ryo Ozaki, Maria Carla Tablante, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Background: Second-generation colon capsule endoscopy (CCE-2) has been reported as a potential tool for monitoring ulcerative colitis (UC). However, its excretion rate is still unsatisfactory, and the bowel preparation regimen is not well tolerated. Furthermore, a standard bowel preparation regimen validated for UC has not been established. The aim of this study was to develop a simple 1-day CCE-2 procedure while evaluating its excretion rate and acceptability in UC. Factors associated with the colonic transit time and acceptability of CCE-2 were evaluated...
April 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29713416/relationship-between-displacement-of-the-psoas-major-muscle-and-spinal-alignment-in-patients-with-adult-spinal-deformity
#15
Yoshiaki Oda, Tomoyuki Takigawa, Ryo Ugawa, Yasuyuki Shiozaki, Haruo Misawa, Yoshihisa Sugimoto, Masato Tanaka, Toshifumi Ozaki
Study Design: Cross sectional study. Purpose: To clarify the difference in position of the psoas muscle between adult spinal deformity (ASD) and lumbar spinal stenosis (LSS). Overview of Literature: Although it is known that the psoas major muscle deviates in ASD patients, no report is available regarding the difference in comparison with LSS patients. Methods: This study investigates 39 patients. For evaluating spinal alignment, pelvic tilt (PT), pelvic incidence (PI), sacral slope, lumbar lordosis (LL), PI-LL, Cobb angle, and the convex side, the lumbar curves were measured...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29698548/the-place-of-the-ozaki-procedure-in-the-treatment-of-aortic-valve-disease
#16
Tornike Sologashvili, René Prêtre
No abstract text is available yet for this article.
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29695674/induction-of-myosin-light-chain-kinase-and-cpi-17-by-tgf-%C3%AE-accelerates-contractile-activity-in-intestinal-epithelial-cells
#17
Md Shafiqul Islam, Noriyuki Kaji, Shoma Mikawa, Qunhui Yang, Moriaki Kusabe, Masatoshi Hori, Hiroshi Ozaki
Epithelial-mesenchymal transition (EMT) is an orchestral and functional change in epithelial cells. Many signaling pathways are involved in EMT, and transforming growth factor-beta (TGF-β) is considered to be one of the most important factors in induction of EMT. In this study, we treated the rat intestinal epithelial cell line (IEC-6) with TGF-β1 as a signaling stimulant. Gross analysis of IEC-6 cells showed typical characteristics of epithelial cells such as cuboidal morphology and cell-cell contact, whereas treatment with TGF-β1 (10 ng·ml-1 ) for 7 days produced robust, spindle-shaped morphology...
April 24, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29691982/triphenylamine-thienothiophene-organic-charge-transport-molecular-materials-effect-of-substitution-pattern-on-their-thermal-photoelectrochemical-and-photovoltaic-properties
#18
Thi Huong Le, Quang-Duy Dao, Mai-Phuong Nghiêm, Sébastien Péralta, Regis Guillot, Quoc Nghi Pham, Akihiko Fujii, Masanori Ozaki, Fabrice Goubard, Thanh-Tuân Bui
Two readily accessible thienothiophene-triphenylamine charge-transport materials have been synthesized by simply varying the substitution pattern of the triphenylamine groups on a central thienothiophene π-linker. The impact of the substitution pattern on the thermal, photoelectrochemical, and photovoltaic properties of these materials was evaluated and, based on theoretical and experimental studies, we found that the isomer in which the triphenylamine groups were located at the 2,5-positions of the thienothiophene core (TT-2,5-TPA) had better π-conjugation than the 3,6-isomer (TT-3,6-TPA)...
April 25, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29688917/large-volume-fluid-resuscitation-for-severe-acute-pancreatitis-is-associated-with-reduced-mortality-a-multicenter-retrospective-study
#19
Takahiro Yamashita, Masayasu Horibe, Masamitsu Sanui, Mitsuhito Sasaki, Hirotaka Sawano, Takashi Goto, Tsukasa Ikeura, Tsuyoshi Hamada, Takuya Oda, Hideto Yasuda, Yuki Ogura, Dai Miyazaki, Kaoru Hirose, Katsuya Kitamura, Nobutaka Chiba, Tetsu Ozaki, Toshitaka Koinuma, Taku Oshima, Tomonori Yamamoto, Morihisa Hirota, Yukiko Masuda, Natsuko Tokuhira, Mioko Kobayashi, Shinjiro Saito, Junko Izai, Alan K Lefor, Eisuke Iwasaki, Takanori Kanai, Toshihiko Mayumi
BACKGROUND AND AIMS: Although fluid resuscitation is critical in acute pancreatitis, the optimal fluid volume is unknown. The aim of this study is to evaluate the association between the volume of fluid administered and clinical outcomes in patients with severe acute pancreatitis (SAP). METHODS: We conducted a multicenter retrospective study at 44 institutions in Japan. Inclusion criteria were age 18 years or older, and diagnosed with SAP from 2009 to 2013. Patients were stratified into 2 groups: administered fluid volume <6000 and ≥6000 mL in the first 24 hours...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29681602/-dose-distribution-optimization-in-combined-intracavitary-and-interstitial-brachytherapy-for-cervical-cancer
#20
Daisuke Ozaki, Makoto Miyazawa, Youji Habano, Motohiro Kawashima, Yoshihiko Hoshino, Takayuki Sutou
PURPOSE: Hybrid inverse treatment planning optimization (HIPO) is a new optimization tool for brachytherapy. We verified its utility using treatment plans for combined intracavitary and interstitial brachytherapy in cervical cancer. MATERIALS & METHODS: We compared the manually optimized plan and the plan optimized using HIPO. The plan using HIPO was optimized with three different methods: needle only, tandem and needle, and all applicators. The dose volume histogram (DVH) parameters such as D90 of high risk clinical target volume (HR-CTV) and D2cc of OAR (rectum, sigmoid colon and bladder) were used to evaluate each treatment plan...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
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