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https://www.readbyqxmd.com/read/28917689/effect-of-early-pitavastatin-therapy-on-coronary-fibrous-cap-thickness-assessed-by-optical-coherence-tomography-in-patients-with-acute-coronary-syndrome-the-escort-study
#1
Tsuyoshi Nishiguchi, Takashi Kubo, Takashi Tanimoto, Yasushi Ino, Yoshiki Matsuo, Takashi Yamano, Kosei Terada, Hiroki Emori, Yosuke Katayama, Akira Taruya, Yuichi Ozaki, Yasutsugu Shiono, Kunihiro Shimamura, Takeyoshi Kameyama, Hironori Kitabata, Tomoyuki Yamaguchi, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVES: The aim of the present study was to assess the effect of early statin therapy on fibrous-cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography. BACKGROUND: Statins can contribute to the stabilization of coronary plaques. METHODS: This is a prospective, randomized, active-controlled, single-center study. Patients with ACS and untreated dyslipidemia were enrolled and randomly allocated (ratio 1:1) to either the early statin group (received pitavastatin 4 mg/day from baseline) or the late statin group (received pitavastatin 4 mg/day from 3 weeks after the baseline)...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917620/disappearing-everyday-materials-the-displacement-of-medical-resources-following-disaster-in-fukushima-japan
#2
Sudeepa Abeysinghe, Claire Leppold, Akihiko Ozaki, Mariko Morita, Masaharu Tsubokura
This study draws upon interviews of medical staff working in the city of Minamisoma, Japan, following the 2011 Triple Disaster. It investigates staff responses to the disruption of material resources as a consequence of the disaster and its management. The disruption of spaces, and the loss of oxygen supplies, food, and medications impacted upon staff experience and the ability of institutions to care for patients. This resulted in a restructuring of spaces and materials as workers made efforts to reconfigure and reestablish healthcare functions...
September 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28914172/effects-of-pharmacological-inhibition-of-plasminogen-binding-on-liver-regeneration-in-rats
#3
Atsushi Miura, Kyoko Ishiguro, Kouta Koizumi, Yuki Yaita, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki
The fibrinolysis system is thought to play an important role in liver regeneration. We previously found that plasminogen (Plg) is localized to the cell surface of regenerating liver tissue as well as proliferating hepatocytes in vitro. Here, we investigated the significance of Plg binding to the cell surface during liver regeneration. Pre-administration of tranexamic acid (TXA), which is a competitive inhibitor of Plg binding, to hepatectomized rats mildly delayed restoration of liver weight in vivo. Although binding of Plg to the cell membrane decreased following TXA administration, TXA showed little effect on hepatocyte proliferation in rats...
September 15, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28913970/human-neutrophils-show-decreased-survival-upon-long-term-exposure-to-clozapine
#4
Aya Goto, Akira Yoshimi, Tomoko Nagai, Mako Ukigai, Akihiro Mouri, Norio Ozaki, Yukihiro Noda
OBJECTIVE: Clozapine is an atypical antipsychotic prescribed for treatment-resistant schizophrenic patients, but treatment with clozapine is strictly limited because it can induce lethal-hematologic side effects. We investigated the effects of short- and long-term exposure of human neutrophils derived from healthy subjects to clozapine and compared them with the effects of reactive metabolite of clozapine, olanzapine, and doxorubicin. METHODS: Neutrophils were exposed to clozapine and olanzapine (1, 10, 50, or 100 μM), reactive metabolite of clozapine (50 or 100 μM), or doxorubicin (0...
September 15, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28904253/genetic-variants-of-ramp2-and-clr-are-associated-with-stroke
#5
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai
AIM: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions...
September 14, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28892664/piezoelectric-nonlinear-vibration-focusing-on-the-second-harmonic-vibration-mode
#6
Ryohei Ozaki, Yaoyang Liu, Hiroshi Hosaka, Takeshi Morita
Resonant piezoelectric devices are driven under high power condition. In such condition, a nonlinear piezoelectric vibration becomes apparent and this nonlinearity should be taken into account in the design procedure using the finite elemental method (FEM). The purpose of this study is to introduce the nonlinear parameter to the FEM and to establish the method for measuring the nonlinear parameter through evaluating a nonlinear model for a piezoelectric vibration. In a previous study about the nonlinear piezoelectric vibration, the third term was mainly focused on because the third mode vibration affects the fundamental vibration in the case of a simple bar-type transducer...
April 22, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28892071/a-novel-rare-variant-r292h-in-rtn4r-affects-growth-cone-formation-and-possibly-contributes-to-schizophrenia-susceptibility
#7
H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y Uno, T Okada, M Ikeda, T Inada, A Branko, D Mori, T Yoshikawa, N Iwata, H Nakamura, T Yamashita, N Ozaki
Reticulon 4 receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11.2, a region that is known to be a hotspot for schizophrenia (SCZ) and autism spectrum disorder (ASD). Recently, rare variants such as copy-number variants and single-nucleotide variants have been a focus of research because of their large effect size associated with increased susceptibility to SCZ and ASD and the possibility of elucidating the pathophysiology of mental disorder through functional analysis of the discovered rare variants...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28890468/dominant-candidatus-accumulibacter-phosphatis-enriched-in-response-to-phosphate-concentrations-in-ebpr-process
#8
Awaluddin Nurmiyanto, Hiroya Kodera, Tomonori Kindaichi, Noriatsu Ozaki, Yoshiteru Aoi, Akiyoshi Ohashi
Candidatus Accumulibacter phosphatis (Accumulibacter), which plays an important role in enhanced biological phosphorus removal in wastewater treatment plants, is phylogenetically classified into two major types (Types I and II). Phosphate concentrations affect the Accumulibacter community of the biomass enriched in treatment plants. Therefore, in the present study, Accumulibacter enrichments were conducted using a down-flow hanging sponge reactor under five conditions and a wide range of controlled phosphate concentrations in order to investigate how phosphate governs the community...
September 9, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28888915/a-case-report-of-locally-advanced-triple-negative-breast-cancer-showing-pathological-complete-response-to-weekly-paclitaxel-with-bevacizumab-treatment-following-disease-progression-during-anthracycline-based-neoadjuvant-chemotherapy
#9
Hideo Shigematsu, Shinji Ozaki, Daisuke Yasui, Taizo Hirata
INTRODUCTION: Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced triple negative breast cancer, however, approximately 5% of cases show disease progression during NAC. Although downstaging is essential to create an opportunity for curative surgery and to improve the local control outcome in such a case, no additional line of chemotherapy has been established. CASE PRESENTATION: A 60-year-old woman was referred to our hospital for an axillary mass presenting three weeks ago and was diagnosed as having right locally advanced (T2N2M0, stage IIIA) triple negative breast cancer...
September 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28883264/treatment-algorithms-for-multiple-myeloma-in-japan
#10
Shuji Ozaki
Recent progress in the development of novel therapeutic agents has remarkably improved the treatment outcome for multiple myeloma (MM). Proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib; immunomodulatory drugs (IMiDs) such as thalidomide, lenalidomide, and pomalidomide; the histone deacetylase (HDAC) inhibitor panobinostat; and the monoclonal antibody, elotuzumab, have all been approved in Japan, although only bortezomib and lenalidomide have been approved for initial therapy. Accordingly, the Japanese Society of Hematology has released updated treatment guidelines for MM...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28883252/switching-therapy-from-intravenous-landiolol-to-transdermal-bisoprolol-in-a-patient-with-thyroid-storm-complicated-by-decompensated-heart-failure-and-gastrointestinal-dysfunction
#11
Shigeo Godo, Yu Kawazoe, Hiroshi Ozaki, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Thyroid storm is a life-threatening disorder that remains a therapeutic challenge. Although β-blockers are the mainstay for treatment, their use can be challenging in cases complicated by rapid atrial fibrillation and decompensated heart failure. We present a case of thyroid storm-associated atrial fibrillation and decompensated heart failure complicated by gastrointestinal dysfunction secondary to diffuse peritonitis that was successfully managed by a switching therapy, in which the continuous intravenous administration of landiolol was changed to bisoprolol via transdermal patch, in the acute phase treatment...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28883224/time-trend-in-interest-and-satisfaction-towards-clinical-training-and-academic-activities-among-early-career-cardiologists%C3%A3-the-japanese-circulation-society-post-graduate-training-survey
#12
Takashi Kohno, Shun Kohsaka, Yasuyoshi Takei, Keiichi Fukuda, Yukio Ozaki, Akira Yamashina
BACKGROUND: Satisfaction among early-career cardiologists is a key performance metric for cardiovascular (CV) educational programs. To assess the time trend in the interest and activities of early-career cardiologists regarding their training, we conducted web-based surveys in 2011 and 2015.Methods and Results:Early-career cardiologists were defined as physicians who planned to attend Japanese Circulation Society (JCS) annual meetings within 10 years of graduation. A total of 272 and 177 participants completed the survey for the years 2011 and 2015, respectively...
September 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28883217/safety-and-efficacy-of-long-term-use-of-tolvaptan-in-patients-with-heart-failure-and-chronic-kidney-disease
#13
Yusuke Uemura, Rei Shibata, Kenji Takemoto, Tomohiro Uchikawa, Masayoshi Koyasu, Shinji Ishikawa, Ryo Imai, Yuta Ozaki, Takashi Watanabe, Tsubasa Teraoka, Masato Watarai, Toyoaki Murohara
BACKGROUND: We assessed the long-term safety and efficacy of tolvaptan in 102 patients with heart failure (HF) and chronic kidney disease (CKD). Median follow-up duration was 1.6 years (1.0-4.4 years).Methods and Results:One patient discontinued tolvaptan because of hypernatremia. There were no changes in renal function or electrolytes during the 1-year follow-up. The cardiac-related death-free or HF-related hospitalization-free survival rate was significantly higher in patients receiving tolvaptan than in propensity score-matched patients who did not receive tolvaptan...
September 5, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28882946/pharmacokinetics-of-morphine-in-rats-with-adjuvant-induced-arthritis
#14
Yoshiaki Kimura, Mika Shibata, Mika Tamada, Noriyuki Ozaki, Kunizo Arai
We investigated the in vivo dynamics and analgesic effect of morphine using an adjuvant-induced arthritis (AA) rat as a model of chronic inflammation. Morphine generally binds to μ-opioid receptors in the brain to exert its effects. After several minutes, it is metabolized by glucuronidation via a UDP-glucuronosyltransferase (UGT). Here, we showed that in AA rats, UGT activity in liver microsomes was reduced. Morphine-free serum fractions in AA rats were also decreased (control, 84.9%; AA, 63.9%) and the expression of ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), which plays a crucial role in morphine bile excretion, decreased to 23...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28878647/adenocarcinoma-of-the-lung-acquiring-resistance-to-afatinib-by-transformation-to-small-cell-carcinoma-a-case-report
#15
Jun Nishimura, Yosuke Miyamoto, Nobukazu Fujimoto, Taichi Ozeki, Kenji Takada, Michiko Asano, Yasuko Fuchimoto, Sae Wada, Shinji Ozaki, Takumi Kishimoto
A 65-year-old woman visited our hospital due to right chest pain and dyspnea on exertion. Chest radiography revealed decreased permeability of the right lung. Computed tomography demonstrated a huge mass in the right upper lobe and right pleural effusion. Right pleural effusion cytology yielded a diagnosis of adenocarcinoma and was positive for mutation of epidermal growth factor receptor (EGFR; exon 21 L858R). Afatinib was selected for the initial treatment. Multiple tumors regressed remarkably, but then rapidly progressed 3 months later...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28870743/accuracy-of-cup-positioning-with-the-computed-tomography-based-two-dimensional-to-three-dimensional-matched-navigation-system-a-prospective-randomized-controlled-study
#16
Kazuki Yamada, Hirosuke Endo, Tomonori Tetsunaga, Takamasa Miyake, Tomoaki Sanki, Toshifumi Ozaki
BACKGROUND: The accuracy of various navigation systems used for total hip arthroplasty has been described, but no publications reported the accuracy of cup orientation in computed tomography (CT)-based 2D-3D (two-dimensional to three-dimensional) matched navigation. METHODS: In a prospective, randomized controlled study, 80 hips including 44 with developmental dysplasia of the hips were divided into a CT-based 2D-3D matched navigation group (2D-3D group) and a paired-point matched navigation group (PPM group)...
August 12, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28868011/esophagobronchial-fistula-in-a-patient-with-squamous-cell-carcinoma-of-the-lung-a-case-report
#17
Taichi Ozeki, Michiko Asano, Nobukazu Fujimoto, Jun Nishimura, Kenji Takada, Yosuke Miyamoto, Yasuko Fuchimoto, Sae Wada, Shinji Ozaki, Takumi Kishimoto
A 73-year-old man was referred to our hospital after a 2-week history of bloody sputum and cough. Computed tomography (CT) images of the chest showed a mass grouped with mediastinal lymph nodes, and bronchoscopy showed a projecting mass in the right main bronchus. After a transbronchial biopsy, the patient was diagnosed with squamous cell carcinoma (T4N2M0 stage IIIB). The patient was treated with systemic chemotherapy, consisting of cisplatin (40 mg/m(2), days 1 and 8) and docetaxel (30 mg/m(2), days 1 and 8), and concurrent thoracic irradiation at a daily dose of 2 Gy...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28862317/is-prolongation-of-corrected-qt-interval-associated-with-seizures-induced-by-electroconvulsive-therapy-reduced-by-atropine-sulfate
#18
Yoko Suzuki, Miho Miyajima, Katsuya Ohta, Noriko Yoshida, Rie Omoya, Mayo Fujiwara, Takafumi Watanabe, Masaki Okumura, Hiroaki Yamazaki, Masayuki Shintaku, Issei Murata, Shigeru Ozaki, Takeshi Sasaki, Mitsuru Nakamura, Hiroshi Suwa, Tetsuo Sasano, Tokuhiro Kawara, Masato Matsuura, Eisuke Matsushima
BACKGROUND: Electrocardiogram abnormalities have been reported during electroconvulsive therapy (ECT). A corrected QT interval (QTc) prolongation indicates delayed ventricular repolarization, which can trigger ventricular arrhythmias such as torsade de pointes (TdP). We examined the QTc changes during generalized tonic-clonic seizures induced by ECT, and the effects of atropine sulfate on these QTc changes. METHODS: We analyzed heart rate, QT interval, and QTc in 32 patients with depression who underwent ECT (25 women, 67...
September 1, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28859304/tilting-at-the-tilted-protease-balance-in-arterial-aneurysmal-disease
#19
Peter Libby, Galina K Sukhova, C Keith Ozaki, Guo-Ping Shi
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28845023/unilateral-luteoma-of-the-ovary-in-a-pregnant-risso-s-dolphin-grampus-griseus
#20
Hironobu Nishina, Takeshi Izawa, Miki Ozaki, Mitsuru Kuwamura, Jyoji Yamate
A white, lobular mass was found in the right ovary of a pregnant Risso's dolphin (Grampus griseus) at necropsy. The mass was unilateral and occupied most of the pre-existing ovarian tissue. Histologically, the mass was composed of diffuse sheets of polyhedral cells with abundant eosinophilic cytoplasm and oval nuclei, separated by fibrous connective tissue. Only a few ovarian follicles were observed at the periphery of the mass. Immunohistochemically, the large eosinophilic cells were positive for vimentin and negative for pan-cytokeratins...
August 27, 2017: Journal of Veterinary Medical Science
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