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https://www.readbyqxmd.com/read/29078233/comparing-the-host-reaction-to-cormatrix-and-different-cardiac-patch-materials-implanted-subcutaneously-in-growing-pigs
#1
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Pierre Gianello
No abstract text is available yet for this article.
October 27, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28958011/stented-cormatrix%C3%A2-conduit-to-bypass-benign-superior-vena-caval-obstruction
#2
Jason M Ali, John Dunning
Surgical venous bypass is an effective treatment option in the management of benign superior vena caval obstruction. Here, we present CorMatrix® as a novel conduit choice, supported internally by an endovascular stent in an attempt to prevent stenosis and reduce reintervention rate following surgical bypass.
August 30, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28940406/congenital-aortic-valve-repair-using-cormatrix-%C3%A2-a-histologic-evaluation
#3
Michael Hofmann, Martin O Schmiady, Barbara E Burkhardt, Hitendu H Dave, Michael Hübler, Oliver Kretschmar, Peter K Bode
BACKGROUND: The reconstruction of heart valves provides substantial benefits, particularly in the pediatric population. We present our experience using decellularized extracellular matrix (dECM, CorMatrix(®) ) for aortic valve procedures. METHODS: We retrospectively reviewed the case histories of 6 patients (aged from 2 months - 14 years) who underwent surgery for severe aortic valve stenosis (n = 4) or regurgitation (n = 2). Aortic valve repair was performed on all patients using dECM as a leaflet replacement or leaflet extension...
September 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28838516/cardiac-regeneration-in-the-human-left-ventricle-after-cormatrix-implantation
#4
Alice Ferng, Alana Connell, Martha Nunez, Kitsie Johnson, Beth Braunhut, Scott Lick, Ankit Desai, Toshinobu Kazui, Ray Runyan, Zain Khalpey
CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium...
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28520544/repair-of-complete-atrioventricular-septal-defects-with-decellularized-extracellular-matrix-initial-and-midterm-outcomes
#5
Adeel Ashfaq, Tyler Brown, Brian Reemtsen
OBJECTIVE: Since April 2010, our institution has repaired complete atrioventricular septal defects (CAVSDs) with a two-patch technique utilizing CorMatrix extracellular material. This material is potentially an attractive patch because of its theorized eventual integration with the host tissue. We sought to analyze initial outcomes of CAVSD repair with CorMatrix. METHODS: Data were collected on consecutive pediatric (age <18) patients receiving two-patch CAVSD repairs with CorMatrix at a single institution from April 2010 to July 2014...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28453800/coronary-sinus-injury-resulting-from-endarterectomy-during-multivessel-bypass-surgery
#6
Mehmet H Akay, Manish K Patel, Igor D Gregoric
Coronary sinus injury is a very rare complication of cardiac surgery and is usually related to coronary sinus perfusion catheter placement for retrograde cardioplegia infusion. It can be either a catheter-related perforation or high-perfusion pressure-related injury to the coronary sinus. Primary repair of the coronary sinus or over-sewing are two possible options to resolve this complication. Decellularized extracellular matrix from porcine intestinal submucosa is widely used as an approved material for repairing cardiac structures...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28423132/repair-of-penetrating-pericardial-and-diaphragmatic-injury-with-cormatrix%C3%A2-patch-in-a-case-of-suicide-attempt
#7
Federica Jiritano, Carlo Garrasi, Lucia Cristodoro, Egidio Bevacqua, Pasquale Mastroroberto
The authors report the case of a suicide attempt. A 59-year-old man with self-inflicted penetrating chest trauma underwent emergency cardiothoracic surgery. Pre-operative computed tomography scan showed critical proximity between the blade and the right ventricle. Intraoperative findings showed a pericardial laceration and a huge diaphragmatic lesion with heart and abdominal organs integrity. The diaphragm muscle was repaired with a CorMatrix® patch, an acceptable alternative to the traditional synthetic mesh avoiding infection and repeated herniation...
January 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28240419/enhanced-antimicrobial-effects-of-decellularized-extracellular-matrix-cormatrix-with-added-vancomycin-and-gentamicin-for-device-implant-protection
#8
Thomas F Deering, Carlos Chang, Carl Snyder, Selvamuthu K Natarajan, Robert Matheny
BACKGROUND: The incidence of cardiac implantable electronic device (CIED) infections has risen significantly over the past years. Although several devices are currently available to decrease the incidence of infection, most are made from nonviable synthetic material and are more prone to infection than vascularized tissue. OBJECTIVE: This study was undertaken to assess the resistance to infection of the CorMatrix CanGaroo (CorMatrix Cardiovascular, Roswell, GA, USA), a CIED envelope made of decellularized extracellular matrix (ECM) hydrated in different antibiotic solutions...
June 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28137992/coronary-sinus-injury-resulting-from-endarterectomy-during-multivessel-bypass-surgery
#9
Mehmet H Akay, Manish K Patel, Igor D Gregoric
Coronary sinus injury is a very rare complication of cardiac surgery and is usually related to coronary sinus perfusion catheter placement for retrograde cardioplegia infusion. It can be either a catheter-related perforation or high-perfusion pressure-related injury to the coronary sinus. Primary repair of the coronary sinus or over-sewing are two possible options to resolve this complication. Decellularized extracellular matrix from porcine intestinal submucosa is widely used as an approved material for repairing cardiac structures...
January 30, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28043458/use-of-cormatrix-for-semilunar-valve-repair-in-children-variations-on-a-theme
#10
EDITORIAL
Nicholas D Andersen
No abstract text is available yet for this article.
2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28043457/porcine-intestinal-submucosa-cormatrix-for-semilunar-valve-repair-in-children-a-word-of-caution-after-midterm-results
#11
Massimo A Padalino, Biagio Castaldi, Marny Fedrigo, Michele Gallo, Fabio Zucchetta, Vladimiro L Vida, Ornella Milanesi, Annalisa Angelini, Giovanni Stellin
Surgery for congenital valve anomalies in children is a challenging topic. We aim to assess early and late functional outcomes of CorMatrix scaffold after repair of aortic and pulmonary valves (PV) in congenital heart disease in a prospective nonrandomized clinical study on children with congenital aortic (Group 1) or PV (Group 2) disease. Primary endpoints were reoperation or reintervention on semilunar valves and echocardiographic evidence of regurgitation or stenosis greater than mild. Results of PV repair in tetralogy of Fallot were compared with a control group of patients who underwent PV repair with polytetrafluoroethylene...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27751739/early-complications-of-biologic-extracellular-matrix-patch-after-use-for-femoral-artery-repair
#12
Nikola Dobrilovic, Peter Soukas, Immad Sadiq, Lisa Goldstein, Jaishankar Raman
BACKGROUND: The CorMatrix (CorMatrix Cardiovascular, Roswell, Ga) biologic extracellular patch derived from porcine small intestinal mucosa provides a biologic scaffold for cellular ingrowth and eventual tissue regeneration. It has been used in a variety of applications, including cardiac and vascular repair procedures. METHODS: CorMatrix was used as a patch arterioplasty for femoral artery repair in conjunction with endarterectomy for seven separate procedures in six patients (one patient underwent staged, bilateral femoral procedures)...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27659148/cormatrix-valved-conduit-in-a-porcine-model-long-term-remodelling-and-biomechanical-characterization
#13
Zahra Mosala Nezhad, Alain Poncelet, Laurent de Kerchove, Caroline Fervaille, Xavier Banse, Xavier Bollen, Jean-Paul Dehoux, Gebrine El Khoury, Pierre Gianello
OBJECTIVES: Porcine small intestinal submucosa extracellular matrix (CorMatrix; CorMatrix Cardiovascular, Rosewell, GA) is a relatively novel tissue substitute used in cardiovascular applications. We investigated the biological reaction and remodelling of CorMatrix as a tri-leaflet valved conduit in a pig model. We hypothesized that CorMatrix maintains a durable architecture as a valved conduit and remodels to resemble surrounding tissues. METHODS: We fashioned the valved conduit using a 7 × 10 cm 4-ply CorMatrix sheet and placed it in the thoracic aorta of seven landrace pigs for 3, 4, 5 and 6 months...
January 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27628444/erratum-experimental-aortic-valve-cusp-extension-with-cormatrix-in-a-porcine-model
#14
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Laurent de Kerchove, Pierre Gianello
No abstract text is available yet for this article.
September 13, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27623276/anterior-leaflet-augmentation-with-cormatrix-porcine-extracellular-matrix-in-twenty-five-patients-unexpected-patch-failures-and-histologic-analysis
#15
Thomas M Kelley, Mohammed Kashem, He Wang, James McCarthy, Nels D Carroll, G William Moser, T Sloane Guy
BACKGROUND: This study reported on the treatment of Carpentier type IIIa and type IIIb mitral regurgitation (MR) with a large patch anterior mitral valve leaflet augmentation technique using CorMatrix (CorMatrix Cardiovascular Inc, Alpharetta, GA) extracellular matrix (ECM). METHODS: A single-site chart review was conducted on patients who underwent anterior leaflet augmentation performed with the Da Vinci surgical robot (Intuitive Surgical, Sunnyvale, CA) or through a median sternotomy...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27583537/experimental-aortic-valve-cusp-extension-with-cormatrix-in-a-porcine-model
#16
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Laurent de Kerchove, Pierre Gianello
Background We tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential. Methods The non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment. Results CorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture...
April 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27264491/correction-of-congenital-cardiac-defects-with-cormatrix-extracellular-matrix-in-pediatric-patients-is-it-really-safe
#17
LETTER
Joaquín Fernández-Doblas, Neiser E Palmer, Joaquín Pérez-Andreu, José L Reyes-Juárez, Dimpna C Albert, Raúl Abella
No abstract text is available yet for this article.
August 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27237540/evaluation-of-explanted-cormatrix-intracardiac-patches-in-children-with-congenital-heart-disease
#18
Jennifer S Nelson, Amer Heider, Ming-Sing Si, Richard G Ohye
BACKGROUND: Animal data demonstrate that intracardiac patches of decellularized porcine small intestine submucosa (CorMatrix; CorMatrix Cardiovascular, Inc, Atlanta, GA) become repopulated with native cells, suggesting the possibility of a substrate for regenerative tissue in humans. We report the only prospective series to date of explanted CorMatrix patches placed in infants with congenital heart disease. METHODS: CorMatrix patches were implanted as the hemi-Fontan baffle in patients during their second stage of palliation...
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26987597/epicardial-infarct-repair-with-bioinductive-extracellular-matrix-promotes-vasculogenesis-and-myocardial-recovery
#19
Holly E M Mewhort, Jeannine D Turnbull, Alessandro Satriano, Kelvin Chow, Jacqueline A Flewitt, Adin-Cristian Andrei, David G Guzzardi, Daniyil A Svystonyuk, James A White, Paul W M Fedak
BACKGROUND: Infarcted myocardium can remodel after successful reperfusion, resulting in left ventricular dilation and heart failure. Epicardial infarct repair (EIR) using a bioinductive extracellular matrix (ECM) biomaterial is a novel surgical approach to promote endogenous myocardial repair and functional recovery after myocardial infarction. Using a pre-clinical porcine model of coronary ischemia-reperfusion, we assessed the effects of EIR on regional functional recovery, safety, and possible mechanisms of benefit...
May 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26912574/small-intestinal-submucosa-extracellular-matrix-cormatrix%C3%A2-in-cardiovascular-surgery-a-systematic-review
#20
REVIEW
Zahra Mosala Nezhad, Alain Poncelet, Laurent de Kerchove, Pierre Gianello, Caroline Fervaille, Gebrine El Khoury
Extracellular matrix (ECM) derived from small intestinal submucosa (SIS) is widely used in clinical applications as a scaffold for tissue repair. Recently, CorMatrix® porcine SIS-ECM (CorMatrix Cardiovascular, Inc., Roswell, GA, USA) has gained popularity for 'next-generation' cardiovascular tissue engineering due to its ease of use, remodelling properties, lack of immunogenicity, absorbability and potential to promote native tissue growth. Here, we provide an overview of the biology of porcine SIS-ECM and systematically review the preclinical and clinical literature on its use in cardiovascular surgery...
June 2016: Interactive Cardiovascular and Thoracic Surgery
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