Read by QxMD icon Read


Nikola Dobrilovic, Peter Soukas, Immad Sadiq, Lisa Goldstein, Jaishankar Raman
BACKGROUND: The CorMatrix (CorMatrix Cardiovascular, Roswell, Ga) biologic extracellular patch derived from porcine small intestinal mucosa provides a biologic scaffold for cellular ingrowth and eventual tissue regeneration. It has been used in a variety of applications, including cardiac and vascular repair procedures. METHODS: CorMatrix was used as a patch arterioplasty for femoral artery repair in conjunction with endarterectomy for seven separate procedures in six patients (one patient underwent staged, bilateral femoral procedures)...
October 14, 2016: Journal of Vascular Surgery
Zahra Mosala Nezhad, Alain Poncelet, Laurent de Kerchove, Caroline Fervaille, Xavier Banse, Xavier Bollen, Jean-Paul Dehoux, Gebrine El Khoury, Pierre Gianello
OBJECTIVES: Porcine small intestinal submucosa extracellular matrix (CorMatrix; CorMatrix Cardiovascular, Rosewell, GA) is a relatively novel tissue substitute used in cardiovascular applications. We investigated the biological reaction and remodelling of CorMatrix as a tri-leaflet valved conduit in a pig model. We hypothesized that CorMatrix maintains a durable architecture as a valved conduit and remodels to resemble surrounding tissues. METHODS: We fashioned the valved conduit using a 7 × 10 cm 4-ply CorMatrix sheet and placed it in the thoracic aorta of seven landrace pigs for 3, 4, 5 and 6 months...
September 22, 2016: Interactive Cardiovascular and Thoracic Surgery
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Laurent de Kerchove, Pierre Gianello
No abstract text is available yet for this article.
September 13, 2016: Thoracic and Cardiovascular Surgeon
Thomas M Kelley, Mohammed Kashem, He Wang, James McCarthy, Nels D Carroll, G William Moser, T Sloane Guy
BACKGROUND: This study reported on the treatment of Carpentier type IIIa and type IIIb mitral regurgitation (MR) with a large patch anterior mitral valve leaflet augmentation technique using CorMatrix (CorMatrix Cardiovascular Inc, Alpharetta, GA) extracellular matrix (ECM). METHODS: A single-site chart review was conducted on patients who underwent anterior leaflet augmentation performed with the Da Vinci surgical robot (Intuitive Surgical, Sunnyvale, CA) or through a median sternotomy...
September 9, 2016: Annals of Thoracic Surgery
Zahra Mosala Nezhad, Alain Poncelet, Caroline Fervaille, Laurent de Kerchove, Pierre Gianello
Background We tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential. Methods The non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment. Results CorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture...
September 1, 2016: Thoracic and Cardiovascular Surgeon
Joaquín Fernández-Doblas, Neiser E Palmer, Joaquín Pérez-Andreu, José L Reyes-Juárez, Dimpna C Albert, Raúl Abella
No abstract text is available yet for this article.
August 2016: Revista Española de Cardiología
Jennifer S Nelson, Amer Heider, Ming-Sing Si, Richard G Ohye
BACKGROUND: Animal data demonstrate that intracardiac patches of decellularized porcine small intestine submucosa (CorMatrix; CorMatrix Cardiovascular, Inc, Atlanta, GA) become repopulated with native cells, suggesting the possibility of a substrate for regenerative tissue in humans. We report the only prospective series to date of explanted CorMatrix patches placed in infants with congenital heart disease. METHODS: CorMatrix patches were implanted as the hemi-Fontan baffle in patients during their second stage of palliation...
October 2016: Annals of Thoracic Surgery
Holly E M Mewhort, Jeannine D Turnbull, Alessandro Satriano, Kelvin Chow, Jacqueline A Flewitt, Adin-Cristian Andrei, David G Guzzardi, Daniyil A Svystonyuk, James A White, Paul W M Fedak
BACKGROUND: Infarcted myocardium can remodel after successful reperfusion, resulting in left ventricular dilation and heart failure. Epicardial infarct repair (EIR) using a bioinductive extracellular matrix (ECM) biomaterial is a novel surgical approach to promote endogenous myocardial repair and functional recovery after myocardial infarction. Using a pre-clinical porcine model of coronary ischemia-reperfusion, we assessed the effects of EIR on regional functional recovery, safety, and possible mechanisms of benefit...
May 2016: Journal of Heart and Lung Transplantation
Zahra Mosala Nezhad, Alain Poncelet, Laurent de Kerchove, Pierre Gianello, Caroline Fervaille, Gebrine El Khoury
Extracellular matrix (ECM) derived from small intestinal submucosa (SIS) is widely used in clinical applications as a scaffold for tissue repair. Recently, CorMatrix® porcine SIS-ECM (CorMatrix Cardiovascular, Inc., Roswell, GA, USA) has gained popularity for 'next-generation' cardiovascular tissue engineering due to its ease of use, remodelling properties, lack of immunogenicity, absorbability and potential to promote native tissue growth. Here, we provide an overview of the biology of porcine SIS-ECM and systematically review the preclinical and clinical literature on its use in cardiovascular surgery...
June 2016: Interactive Cardiovascular and Thoracic Surgery
Petros V Anagnostopoulos
No abstract text is available yet for this article.
2015: Seminars in Thoracic and Cardiovascular Surgery
Narutoshi Hibino
No abstract text is available yet for this article.
2015: Seminars in Thoracic and Cardiovascular Surgery
Narutoshi Hibino, Patrick McConnell, Toshiharu Shinoka, Mahim Malik, Mark Galantowicz
A number of materials have been used for the repair of congenital heart disease. However, an ideal material is yet to be discovered. Decellularized extracellular matrix from porcine small intestinal submucosa (CorMatrix) has been developed and commercialized as a biological tissue substitute. This has been used for valvuloplasty, sepal defect repair, or angioplasty as a patch. In this study, we demonstrate our preliminary experience using CorMatrix as a tube graft. A retrospective review of 13 patients who underwent cardiac surgery using CorMatrix as an interposition graft was performed (10 patients for central pulmonary artery reconstruction in comprehensive stage II surgery for hypoplastic left-sided heart syndrome and 3 patients for aortic arch reconstruction in interrupted aortic arch)...
2015: Seminars in Thoracic and Cardiovascular Surgery
Adele K Evans, Neal D Kon
Type IV laryngotracheo-esophageal cleft (LTEC) extending to the level of the carina presents unique challenges to operative repair, particularly with respect to soft tissue durability. This is the first report of CorMatrix(®) extra-cellular matrix (ECM) material use as an interposition graft in a four-layered LTEC repair. At day seven post-operatively, there was epithelialization along the surface of the trachea. At 3 months, she was stable for tracheotomy. At 6 months, the posterior wall resembled completely native tissue...
December 2015: International Journal of Pediatric Otorhinolaryngology
Joseph J DuBose, Gerald R Fortuna, Kristofer M Charlton-Ouw, Naveed Saqib, Charles C Miller, Anthony L Estrera, Hazim J Safi, Ali Azizzadeh
OBJECTIVE: The treatment of segmental arteriovenous fistula aneurysms (AVFAs) remains a challenge in dialysis access preservation. We examined our experience with the use of tubularized extracellular matrix (ECM; CorMatrix, Roswell, Ga) for AVFA repair. METHODS: Between October 2013 and January 2015, we conducted a prospective study of CorMatrix ECM for AVFA repair. All patients underwent intraoperative fistulography. Patients with central venous stenosis or occlusion had simultaneous angioplasty and stenting as indicated...
February 2016: Journal of Vascular Surgery
Jennifer S Woo, Michael C Fishbein, Brian Reemtsen
BACKGROUND: CorMatrix is a decellularized porcine small intestinal submucosa extracellular matrix that has gained attention as a promising alternative to current materials used in cardiac repair. While animal models demonstrate integration of CorMatrix material with host tissue, the histologic characteristics of CorMatrix used in humans are less well-characterized. In this retrospective study, we report our experience with CorMatrix material used in pediatric congenital heart surgery and describe the histology of CorMatrix material and of surrounding native tissue in explanted specimens...
January 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Adriana Luk, Vivek Rao, Robert J Cusimano, Tirone E David, Jagdish Butany
Decellularized extracellular matrix from porcine intestinal submucosa is available as an approved material for the repair of tissues including cardiac structures. Although pathologic findings of explanted CorMatrix (CorMatrix Cardiovascular, Inc, Roswell, GA) used for valvular repair have been reported in the pediatric population, there is a paucity of data in the adult population. Herein, we report the histologic changes in explanted CorMatrix from 2 adults at 10 and 18 months post-implant.
June 2015: Annals of Thoracic Surgery
Walid K Abu Saleh, Odeaa Al Jabbari, Jane Grande-Allen, Mahesh Ramchandani
BACKGROUND: Although extracellular xenograft repair has produced encouraging results when applied to cardiac, valvular, and specific aortic defects, its employment as a tube graft to replace the ascending aorta has not been reported. We describe a patient who underwent resection and replacement of an infected ascending aortic graft with an extracellular matrix conduit. The patient did well, but 14 months later developed a pseudoaneurysm from the staple line used to construct the extracellular matrix conduit...
August 2015: Journal of Cardiac Surgery
Frances Rosario-Quinones, Margret S Magid, Jen Yau, Amit Pawale, Khanh Nguyen
BACKGROUND: Decellularized porcine small intestine submucosa (CorMatrix, Atlanta, GA) patches have been used in the repair of congenital heart malformations. Tissue reaction to the material may create hemodynamic dysfunction and necessitate explantation. We reviewed our series of congenital cardiac patients who had a reoperation after the implantation of CorMatrix patches. METHODS: Medical records of pediatric cardiac patient who received CorMatrix patches and those of patients who underwent reoperation were reviewed...
April 2015: Annals of Thoracic Surgery
Steve Bibevski, Frank G Scholl
A need persists for a prosthetic, systemic atrioventricular valve replacement in the pediatric population that can be customized to a wide range of annular sizes, has a low risk of thrombosis, possesses optimal hemodynamic performance, and has the potential to remodel and grow with the patient. We describe a technique for successful systemic atrioventricular valve replacement in a 4-month-old infant by use of a handmade, bileaflet systemic atrioventricular prosthesis constructed from porcine extracellular matrix...
February 2015: Annals of Thoracic Surgery
Adam C Adler, Vatsala Tewari, Frederick Conlin
No abstract text is available yet for this article.
January 2015: Anesthesia and Analgesia
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"