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https://www.readbyqxmd.com/read/27785133/application-of-the-cardiocel-bovine-pericardial-patch-a-preliminary-report
#1
Michał Sobieraj, Edyta Cudak, Wojciech Mrówczyński, Tomasz K Nałęcz, Przemysław Westerski, Michał Wojtalik
INTRODUCTION: Animal pericardial patches are widely used in adult and pediatric cardiac surgery. A search is ongoing for a new material with optimal surgical properties that will reduce intraoperative bleeding and the occurrence of restenosis, calcification, and pseudoaneurysms in long-term observation. One product of interest is the CardioCel bovine pericardial patch. AIM: Evaluation of the short-term results of CardioCel bovine pericardial patch implantation during pediatric cardiac surgery...
September 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/27570204/planar-biaxial-testing-of-heart-valve-cusp-replacement-biomaterials-experiments-theory-and-material-constants
#2
Michel R Labrosse, Reza Jafar, Janet Ngu, Munir Boodhwani
OBJECTIVES: Aortic valve (AV) repair has become an attractive option to correct aortic insufficiency. Yet, cusp reconstruction with various cusp replacement materials has been associated with greater long-term repair failures, and it is still unknown how such materials mechanically compare with native leaflets. We used planar biaxial testing to characterize six clinically relevant cusp replacement materials, along with native porcine AV leaflets, to ascertain which materials would be best suited for valve repair...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/25431988/an-evaluation-of-admedus-tissue-engineering-process-treated-adapt-bovine-pericardium-patch-cardiocel-for-the-repair-of-cardiac-and-vascular-defects
#3
REVIEW
Geoff Strange, Christian Brizard, Tom R Karl, Leon Neethling
Tissue engineers have been seeking the 'Holy Grail' solution to calcification and cytotoxicity of implanted tissue for decades. Tissues with all of the desired qualities for surgical repair of congenital heart disease (CHD) are lacking. An anti-calcification tissue engineering process (ADAPT TEP) has been developed and applied to bovine pericardium (BP) tissue (CardioCel, AdmedusRegen Pty Ltd, Perth, WA, Australia) to eliminate cytotoxicity, improve resistance to acute and chronic inflammation, reduce calcification and facilitate controlled tissue remodeling...
March 2015: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/25266083/evaluation-of-an-established-pericardium-patch-for-delivery-of-mesenchymal-stem-cells-to-cardiac-tissue
#4
Aditya V Vashi, Jacinta F White, Keith M McLean, William M L Neethling, David I Rhodes, John A M Ramshaw, Jerome A Werkmeister
The present study has evaluated a commercial pericardial material for its capacity to assist as a natural extracellular matrix (ECM) patch for the delivery and retention of mesenchymal stem cells for cardiac repair. The repair of cardiac tissue with cells delivered by an appropriate bioscaffold is expected to offer a superior, long-lasting treatment strategy. The present material, CardioCel®, is based on acellular pericardium that has been stabilized by treatments, including a low concentration of glutaraldehyde, that eliminate calcification after implantation...
June 2015: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/25256436/evaluation-of-an-established-pericardium-patch-for-delivery-of-mesenchymal-stem-cells-to-cardiac-tissue
#5
Aditya V Vashi, Jacinta F White, Keith M McLean, William M L Neethling, David I Rhodes, John A M Ramshaw, Jerome A Werkmeister
The present study has evaluated a commercial pericardial material for its capacity to assist as a natural extracellular matrix patch for the delivery and retention of mesenchymal stem cells for cardiac repair. The repair of cardiac tissue with cells delivered by an appropriate bioscaffold is expected to offer a superior, long-lasting treatment strategy. The present material, CardioCel®, is based on acellular pericardium that has been stabilized by treatments, including a low concentration of glutaraldehyde, that eliminate calcification after implantation...
September 25, 2014: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/25218528/new-engineering-treatment-of-bovine-pericardium-confers-outstanding-resistance-to-calcification-in-mitral-and-pulmonary-implantations-in-a-juvenile-sheep-model
#6
COMPARATIVE STUDY
Christian P Brizard, Johann Brink, Steven B Horton, Glenn Anthony Edwards, John C Galati, William M L Neethling
OBJECTIVE: To conduct a test of noninferiority for CardioCel (Admedus, Brisbane, Australia), a chemically engineered bovine pericardium over autologous pericardium treated intraoperatively with glutaraldehyde in a chronic juvenile sheep model of pulmonary valve (PV) and mitral valve (MV) reconstruction. METHODS: We replaced the posterior leaflet of the MV and of 1 PV cusp with patches in ewes aged 10 months. There were 2 groups: CardioCel (n = 6) and control (n = 4)...
December 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24431173/biostability-durability-and-calcification-of-cryopreserved-human-pericardium-after-rapid-glutaraldehyde-stabilization-versus-multistep-adapt-r-treatment-in-a-subcutaneous-rat-model
#7
William Neethling, Christian Brizard, Laura Firth, Ross Glancy
OBJECTIVES: Autologous pericardium rapidly fixed with glutaraldehyde (GA) in theatre is considered in many cardiac surgery centres the best material currently available for intracardiac, valvular or vascular repair. Implanted non-fixed autologous tissues suffer rapid degeneration, shrinkage and absorption whereas standard xenotypic fixed tissues cause local cytotoxicity and calcification. In the present study, using a subcutaneous rat model, we tested the biostability, durability and calcification potential of four different pericardium patches treated with GA and relevant to current clinical practice...
April 2014: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/23832918/evaluation-of-a-tissue-engineered-bovine-pericardial-patch-in-paediatric-patients-with-congenital-cardiac-anomalies-initial-experience-with-the-adapt-treated-cardiocel-r-patch
#8
William M L Neethling, Geoff Strange, Laura Firth, Francis E Smit
OBJECTIVES: This study evaluated the safety, efficacy and clinical performance of the tissue-engineered ADAPT® bovine pericardial patch (ABPP) in paediatric patients with a range of congenital cardiac anomalies. METHODS: In this single-centre, prospective, non-randomized clinical study, paediatric patients underwent surgery for insertion of the ABPP. Primary efficacy measures included early (<30 day) morbidity; incidence of device-related complications; haemodynamic performance derived from echocardiography assessment at 6- and 12-month follow-up and magnetic resonance imaging findings in 10 randomly selected patients at 12 months...
October 2013: Interactive Cardiovascular and Thoracic Surgery
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