keyword
MENU ▼
Read by QxMD icon Read
search

Irradiation

keyword
https://www.readbyqxmd.com/read/29786904/visible-light-induced-supra-amphiphilic-switch-leads-to-transition-from-supramolecular-nanosphere-to-nanovesicle-activated-by-pillar-5-arene-based-host-guest-interaction
#1
Pengyu Li, Qianfang Yao, Baozhong Lü, Guiping Ma, Meizhen Yin
A photoresponsive host-guest supramolecular complex (WP5⊃G) constructed by water-soluble pillar[5]arene (WP5) and spiropyran derivative (G) is presented. The spontaneous isomerization of G from spiropyran (SP) form to ring-opened merocyanine (MC) form happens either alone or in WP5⊃G in aqueous media. Irradiated by visible light, G can be converted into SP form completely and the hydrophilicity will be changed. G and WP5⊃G are both verified to self-assemble into nanospheres. Upon exposure to visible light, WP5⊃G reassemble into nanovesicles due to the change of supra-amphiphilicity, while G alone does not have this transition...
May 22, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29786715/cancer-cell-membrane-coated-magnetic-nanoparticles-for-mr-nir-fluorescence-dual-modal-imaging-and-photodynamic-therapy
#2
Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu, Xiaolong Liu
Theranostic nanoprobes integrated with dual-modal imaging and therapeutic functions, such as photodynamic therapy (PDT), have exhibited significant potency in cancer treatments due to their high imaging accuracy and non-invasive advantages for cancer elimination. However, biocompatibility and highly efficient accumulation of these nanoprobes in tumor are still unsatisfactory for clinical application. In this study, a photosensitizer -loaded magnetic nanobead with surface further coated with a layer of cancer cell membrane (SSAP-Ce6@CCM) was designed to improve the biocompatibility and cellular uptake and ultimately achieve enhanced MR/NIR fluorescence imaging and PDT efficacy...
May 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29786710/direct-observation-of-the-oxidation-of-dna-bases-by-phosphate-radicals-formed-under-radiation-a-model-of-the-backbone-to-base-hole-transfer
#3
Jun Ma, Jean-Louis Marignier, Pascal Pernot, Chantal Houée-Levin, Anil Kumar, Michael D Sevilla, Amitava Adhikary, Mehran Mostafavi
In irradiated DNA, by the base-to-base and backbone-to-base hole transfer processes, the hole (i.e., the unpaired spin) localizes on the most electropositive base, guanine. Phosphate radicals formed via ionization events in the DNA-backbone must play an important role in the backbone-to-base hole transfer process. However, earlier studies on irradiated hydrated DNA, on irradiated DNA-models in frozen aqueous solution and in neat dimethyl phosphate showed the formation of carbon-centered radicals and not phosphate radicals...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29786420/bacteria-driven-hypoxia-targeting-for-combined-biotherapy-and-photothermal-therapy
#4
Wenfei Chen, Ying Wang, Ming Qin, Xudong Zhang, Zhirong Zhang, Xun Sun, Zhen Gu
The facultative anaerobe Salmonella strain VNP20009 selectively colonizes into tumors following systemic injection due to its preference for the hypoxia in the tumor cores. However, the Phase 1 Clinical Trial of VNP20009 has been terminated mainly due to its weak anti-tumor effects and exhibition of dose-dependent toxicity. Here we leveraged the advantages of VNP20009 biotherapy together with polydopamine-mediated photothermal therapy in order to enhance the antitumor efficacy toward malignant melanoma. VNP20009 was coated with polydopamine via oxidation and self-polymerization, which was then injected into tumor-bearing mice via the tail vein...
May 22, 2018: ACS Nano
https://www.readbyqxmd.com/read/29786073/integrin-%C3%AE-6%C3%AE-4-src-akt-signaling-induces-cellular-senescence-by-counteracting-apoptosis-in-irradiated-tumor-cells-and-tissues
#5
Seung Hee Jung, Minyoung Lee, Hyun A Park, Hyung Chul Lee, Donghee Kang, Hyun Jung Hwang, Chanho Park, Dong-Min Yu, Yu Ri Jung, Mi-Na Hong, Yong-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Lee
Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism remains unknown. Here we show that the activation of integrin β4 is essential for IR-induced cellular senescence. IR treatment results in the phosphorylation of integrin β4 at tyrosine residue 1510, leading to activation of the integrin α6β4-Src-AKT signaling pathway...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29785821/optimizing-photodynamic-therapy-regimens-variables-in-irradiation-may-influence-outcomes
#6
S Ibbotson
No abstract text is available yet for this article.
May 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29785759/effect-of-2-94-%C3%A2%C2%B5m-er-yag-laser-on-the-chemical-composition-of-hard-tissues
#7
Abtesam Aljdaimi, Hugh Devlin, Mark Dickinson, Abdullatif Alfutimie
The aim was to investigate the effect of the Er-YAG laser radiation on morphology and chemical composition of enamel, dentin, and bone. The specimens of the three groups were irradiated with a very long pulse mode (VLP) of 2.94 µm Er-YAG laser with 100 mJ pulse energy and energy density of 8.42 J/ cm2 for 30 s, at a repetition rate of 15 Hz. The organic and inorganic content of the samples were investigated by Fourier Transforms Infrared spectroscopy (FTIR). The morphological characteristics were investigated with scanning electron microscopy (SEM) and elemental analysis (calcium and phosphorus) with energy-dispersive X-ray spectroscopy (EDX)...
May 21, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29785615/molecular-characterization-of-proton-beam-induced-mutations-in-soybean-using-genotyping-by-sequencing
#8
Woon Ji Kim, Jaihyunk Ryu, Juhyun Im, Sang Hun Kim, Si-Yong Kang, Jeong-Hee Lee, Sung-Hwan Jo, Bo-Keun Ha
Proton beam irradiation is a next-generation technique to develop mutant crop varieties. The mutagenic effects and molecular mechanisms of radiation are important multi-disciplinary research subjects. This study was conducted to investigate the types of mutations induced in the soybean genome by proton beam irradiation. In total, 22 plants, including 10 M2 plants treated with proton beam irradiation at 118 and 239 Gy, each, and two wild-type plants (Daepung) were sequenced by genotyping-by-sequencing (GBS)...
May 21, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29785486/radiation-induced-bystander-effect-in-large-japanese-field-mouse-apodemus-speciosus-embryonic-cells
#9
Kentaro Ariyoshi, Tomisato Miura, Kosuke Kasai, Nakata Akifumi, Yohei Fujishima, Mitsuaki A Yoshida
Although evidence suggests that ionizing radiation can induce the bystander effect (radiation-induced bystander effect: RIBE) in cultured cells or mouse models, it is unclear whether the effect occurs in cells of wild animals. We investigated medium-mediated bystander micronucleus (MN) formation and DNA damage in un-irradiated cells from a large Japanese field mouse (Apodemus speciosus). We isolated four clones of A. speciosus embryonic fibroblasts (A603-1, A603-2, A603-3, and A603-4) derived from the same mother, and examined their radiation sensitivity using the colony-forming assay...
May 22, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29785440/an-immunoconjugated-up-conversion-nanocomplex-for-selective-imaging-and-photodynamic-therapy-against-her2-positive-breast-cancer
#10
Gonzalo Ramírez-García, Sandeep S Panikar, Tzarara López-Luke, Valeria Piazza, Miguel Angel Honorato-Colin, Tanya Camacho-Villegas, Rodolfo Hernández-Gutiérrez, Elder De la Rosa
Photodynamic therapy represents a very attractive therapeutic tool considered to be effective, minimally invasive and minimally toxic. However, conventional photodynamic therapy actually has two main constraints: the limited penetration depth of visible light needed for its activation, and the lack of selectivity. Considering this, this work reports the synthesis and evaluation of a novel nanoconjugate for imaging and selective photodynamic therapy against HER2-positive breast cancer, a particularly aggressive form of the disease...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29785334/radiotherapy-for-inoperable-merkel-cell-carcinoma-a-systematic-review-and-pooled-analysis
#11
Parth Patel, Chirag Modi, Beth McLellan, Nitin Ohri
Background: Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking. Objective: We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC. Methods: We performed a systematic review of the current literature. Articles published in English in the PubMed database up to July 29, 2016, were evaluated. Results: Eight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29784957/metabolic-reprogramming-in-leaf-lettuce-grown-under-different-light-quality-and-intensity-conditions-using-narrow-band-leds
#12
Kazuyoshi Kitazaki, Atsushi Fukushima, Ryo Nakabayashi, Yozo Okazaki, Makoto Kobayashi, Tetsuya Mori, Tomoko Nishizawa, Sebastian Reyes-Chin-Wo, Richard W Michelmore, Kazuki Saito, Kazuhiro Shoji, Miyako Kusano
Light-emitting diodes (LEDs) are an artificial light source used in closed-type plant factories and provide a promising solution for a year-round supply of green leafy vegetables, such as lettuce (Lactuca sativa L.). Obtaining high-quality seedlings using controlled irradiation from LEDs is critical, as the seedling health affects the growth and yield of leaf lettuce after transplantation. Because key molecular pathways underlying plant responses to a specific light quality and intensity remain poorly characterised, we used a multi-omics-based approach to evaluate the metabolic and transcriptional reprogramming of leaf lettuce seedlings grown under narrow-band LED lighting...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784551/residual-byproducts-of-peroxide-crosslinked-vitamin-e-blended-ultrahigh-molecular-weight-polyethylene
#13
David A Bichara, Caitlin C O'Brien, Brinda N Doshi, Gunnlaugur P Nielsen, Ebru Oral, Orhun K Muratoglu
BACKGROUND: Wear resistance of ultrahigh molecular weight polyethylene (UHMWPE) is improved via ionizing radiation crosslinking and subsequent high temperature melting for improved toughness. Our group has previously reported that crosslinking can also be achieved chemically using organic peroxides. However, volatile peroxide byproducts are generated during consolidation. The purpose of this study was to quantify elution of volatile peroxide byproducts from UHMWPE before and after in vivo implantation, and to determine their effects on local tissues...
March 13, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29784451/randomized-trial-comparing-two-methods-of-re-irradiation-after-salvage-surgery-in-head-and-neck-squamous-cell-carcinoma-once-daily-split-course-radiotherapy-with-concomitant-chemotherapy-or-twice-daily-radiotherapy-with-cetuximab
#14
Yungan Tao, Laura Faivre, Anne Laprie, Pierre Boisselier, Christophe Ferron, Guy Michel Jung, Séverine Racadot, Bernard Gery, Caroline Even, Ingrid Breuskin, Jean Bourhis, François Janot
BACKGROUND: A previous randomized trial in recurrent Head and Neck squamous-cell carcinoma (HNSCC) has shown re-irradiation combined with chemotherapy after salvage surgery significantly improved disease-free survival (DFS). The objective of this randomized trial was to compare two methods of re-irradiation in terms of toxicity and survival. PATIENTS AND METHODS: Patients with recurrence/second primary in previously irradiated area were randomly allocated to receive either 60 Gy over 11 weeks with concomitant 5FU - hydroxyurea (VP-arm), or 60 Gy (1...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29784399/the-application-of-microwave-digestion-in-decomposing-some-refractory-ore-samples-with-solid-fusion-agent
#15
Yan Lu, Gang Li, Wei Liu, Hongyan Yuan, Dan Xiao
It is known that most of the refractory ore are the basis of national economy and widely applied in various fields, however, the complexity of the chemical composition and the diversity of the crystallinity in the mineral phases make the sample pre-treatment of refractory ore still remains a challenge. In this work, the complete decomposition of the refractory ore sample can be achieved just by exposing the solid fusion agent and the refractory ore sample in the microwave irradiation environment for a few minutes, and induced by a drop of water...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784359/facile-fabrication-of-ternary-tio-2-gold-nanoparticle-graphene-oxide-nanocomposites-for-recyclable-surface-enhanced-raman-scattering
#16
Lu-Lu Qu, Na Wang, Gen Zhu, T P Yadav, Xinting Shuai, Dandan Bao, Guohai Yang, Dawei Li, Haitao Li
A bi-functional ternary nanocomposite was developed by decorating TiO2 and gold nanoparticles on the reduced graphene oxide nanosheets (TiO2 -Au-rGO) for recyclable surface enhanced Raman scattering (SERS) detection. TiO2 -Au-rGO nanocomposites have been shown to demonstrate the superior SERS performances, which can be used for highly sensitive detection of rhodamine 6 G with a limit of detection of 1.2 × 10-10 M. Subsequently, the surface can be cleaned automatically by the photocatalytic degradation of the adsorbed analytes into inorganic small molecules under visible light irradiation...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784026/effects-of-ionizing-radiation-on-the-viability-and-proliferative-behavior-of-the-human-glioblastoma-t98g-cell-line
#17
Hossam Murad, Yaman Alghamian, Abdulmunim Aljapawe, Ammar Madania
OBJECTIVE: Radiotherapy is the traditional therapy for glioma patients. Glioma has poor response to ionizing radiation (IR). Studying radiation-induced cell death can help in understanding the cellular mechanisms underlying its radioresistance. T98G cell line was irradiated with Co60 source by 2 or 10 Gy. MTT assay was used to calculate the surviving fraction. Cell viability, cell cycle distribution and apoptosis assays were conducted by flow cytometry for irradiated and control cells for the 10 Gy dose...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29783855/iec-specific-igf1-promotes-the-expansion-of-intestinal-stem-cells-during-epithelial-regeneration-and-functions-on-the-intestinal-immune-homeostasis
#18
Yu Zheng, Yongli Song, Qi Han, Wenjie Liu, Jiuzhi Xu, Zhengquan Yu, Ran Zhang, Ning Li
It is well known that insulin-like growth factor 1 (IGF1) acts as a trophic factor in small intestine under both physiological and pathophysiological conditions. However, it still lacks direct in vivo evidence of the functions of intestinal epithelial cells (IECs)-specific IGF1 under both normal and pathological conditions. Using IEC-specific IGF1-knockout (cKO) mice and Lgr5-eGFP-CreERT mice, we demonstrate that IEC-specific IGF1 can enhance nutrient uptake, reduce protein catabolism and energy consumption, and promotes the proliferation and expansion of intestinal epithelial cells, including ISCs and intestinal secretory cells...
May 21, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29783745/loading-of-indocyanine-green-within-polydopamine-coated-laponite-nanodisks-for-targeted-cancer-photothermal-and-photodynamic-therapy
#19
Fanli Xu, Mengxue Liu, Xin Li, Zhijuan Xiong, Xueyan Cao, Xiangyang Shi, Rui Guo
The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) in cancer treatment has attracted much attention in recent years. However, developing highly efficient and targeted therapeutic nanoagents for amplifying PTT and PDT treatments remains challenging. In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin αv β₃ through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface...
May 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783153/microwave-assisted-pyrolysis-of-textile-dyeing-sludge-and-migration-and-distribution-of-heavy-metals
#20
Hedong Zhang, Zuopeng Gao, Yang Liu, Chunmei Ran, Xiao Mao, Qinhao Kang, Wenya Ao, Jie Fu, Jing Li, Guangqing Liu, Jianjun Dai
This study investigated the pyrolysis characteristic of textile dyeing sludge (DS) using an auger pyrolyser under microwave irradiation at different pyrolysis temperature. The migration and distribution characteristic of heavy metals and their potential ecological risks were investigated using inductively coupled plasma mass spectrometry (ICP-MS) techniques. Temperature and additives (e.g. Ca-bentonite, kaolin and CaO) significantly affected product distribution and yields. Heavy metals showed different enrichment characteristics during pyrolysis and a great percentage of the heavy metals was retained in the sludge char (SC), depending on different temperatures and additives...
May 1, 2018: Journal of Hazardous Materials
keyword
keyword
62614
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"