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https://www.readbyqxmd.com/read/28454462/effects-of-irradiation-on-radioresistance-hotair-and-epithelial-mesenchymal-transition-cancer-stem-cell-marker-expression-in-esophageal-squamous-cell-carcinoma
#1
Chunli Da, Li Wu, Yuting Liu, Ruozheng Wang, Ruiguang Li
Radiotherapy is a common therapeutic strategy used to treat esophageal squamous cell carcinoma (ESCC). However, tumor cells often develop radioresistance, thereby reducing treatment efficacy. Here, we aimed to identify the mechanisms through which ESCC cells develop radioresistance and identify associated biomarkers. Eca109 cells were exposed to repeated radiation at 2 Gy/fraction for a total dose of 60 Gy (Eca109R60/2Gy cells). MTT and colony formation assays were performed to measure cell proliferation and compare the radiation biology parameters of Eca109 and Eca109R60/2Gy cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454405/expression-of-b-cell-translocation-gene-2-is-associated-with-favorable-prognosis-in-hepatocellular-carcinoma-patients-and-sensitizes-irradiation-induced-hepatocellular-carcinoma-cell-apoptosis-in-vitro-and-in-nude-mice
#2
Yuanyuan Chen, Chuan Chen, Zhimin Zhang, He Xiao, Bijing Mao, Huan Huang, Chenchen Ding, Lin Lei, Hui Zhang, Jian Li, Mei Jiang, Ge Wang
B-cell translocation gene 2 (BTG2) proteins have been reported to be putative tumor suppressors in various cancer types. The present study first assessed BTG2 expression in 44 human liver cancer tissue specimens, then investigated BTG2 expression in the regulation of hepatocellular carcinoma (HCC) cell apoptosis with or without radiotherapy in vitro and in vivo. The results revealed that BTG2 protein expression was significantly reduced in HCC tissues, and associated with better survival for HCC patients (P=0...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454299/rna-interference-mediated-gene-silencing-of-cyclophilin-a-enhances-the-radiosensitivity-of-paa-human-lung-adenocarcinoma-cells-in-vitro
#3
Xin Jiang, Qiao-Li Zhang, Ye-Hong Tian, Jin-Chang Huang, Guo-Lin Ma
Radiotherapy is currently the major therapeutic strategy for patients with lung cancer. However, radioresistance and various side effects continue to present challenging issues for this form of treatment. A recent study demonstrated that cyclophilin A (CyPA) was overexpressed in non-small cell lung cancer and, therefore, presents a novel potential therapeutic target. In addition, gene-radiotherapy is a novel method for cancer treatment. Therefore, the objective of the present study was to investigate the potential effect of CyPA silencing on radiosensitivity in human lung adenocarcinoma in vitro...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454285/stereotactic-radiosurgery-for-brain-metastasis-from-gynecological-malignancies
#4
Ekkehard Kasper, Franziska Ippen, Eric Wong, Eric Uhlmann, Scott Floyd, Anand Mahadevan
Brain metastases are relatively uncommon in gynecological malignancies, and there is limited available data on their management. The present study reports the outcomes of patients with brain metastasis from gynecological malignancies who were treated with stereotactic radiosurgery (SRS). Patients with brain metastasis from a gynecological primary site were treated with SRS using the Cyberknife™ frameless SRS system. Primary lesions were treated with a single fraction of 16-22 Gy. A total of 3 resection cavities were treated with 8 Gy 3 times, meaning a total of 24 Gy, and 1 recurrent lesion was re-irradiated with 5 Gy 5 times, meaning a total of 25 Gy...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454129/photostability-of-pulsed-laser-deposited-as-sub-x-sub-te-sub-100-x-sub-x-40-50-60-amorphous-thin-films
#5
Petra Hawlová, Marek Bouška, Virginie Nazabal, Emeline Baudet, Zdeněk Černošek, Petr Němec
As<sub>x</sub>Te<sub>100-x</sub> amorphous thin films were fabricated by a pulsed laser deposition technique with the aim of finding photostable layers in as-deposited but preferably in relaxed (annealed) state. Photostability was studied in terms of the films' stability of refractive index and bandgap under near-bandgap light irradiation. As<sub>40</sub>Te<sub>60</sub> and As<sub>50</sub>Te<sub>50</sub> layers were found to be photostable in both as-deposited as well as relaxed states...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454074/photocatalytic-degradation-of-dye-using-ceo2-scb-composite-catalysts
#6
Duangdao Channei, Auppatham Nakaruk, Sukon Phanichphant
The main task of the present work is to enhance the photocatalytic degradation efficiency of methylene blue (MB) by using CeO2/sugarcane bagasse (SCB) composite catalysts. Homogeneous precipitation method was used to synthesis CeO2-SCB composite catalysts by adding SCB powder to precursor solution of Ce base-metal. The structural analytical data indicated the pure cubic fluorite structure of CeO2. Morphological images revealed the coating of CeO2 layer on high surface area of SCB core-shell. The chemical analysis presented spectrum of the Ce 3d in CeO2/SCB sample existed in the form of the Ce(3+) and Ce(4+) mixed- valence states...
April 22, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454070/principles-and-applications-of-photoelectrochemical-sensing-strategies-based-on-biofunctionalized-nanostructures
#7
REVIEW
Yang Zang, Jianping Lei, Huangxian Ju
Photoelectrochemical (PEC) biosensing is a popular research hotspot that has attracted substantial attention from chemists and biologists due to its low cost and desirable sensitivity. The PEC biosensing mainly refers to the influence of the interaction between recognition element and analyte on photocurrent signal, which involves the charge and energy transfer of PEC reaction between electron donor/acceptor and photoactive material upon light irradiation. Understanding the fundamentals of PEC strategy benefits the development of next-generation PEC sensors...
April 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28454069/cns-bioavailability-and-radiation-protection-of-normal-hippocampal-neurogenesis-by-a-lipophilic-mn-porphyrin-based-superoxide-dismutase-mimic-mntnbuoe-2-pyp-5
#8
David Leu, Ivan Spasojevic, Huy Nguyen, Brian Deng, Artak Tovmasyan, Tin Weitner, Romulo S Sampaio, Ines Batinic-Haberle, Ting-Ting Huang
Although radiation therapy can be effective against cancer, potential damage to normal tissues limits the amount that can be safely administered. In central nervous system (CNS), radiation damage to normal tissues is presented, in part, as suppressed hippocampal neurogenesis and impaired cognitive functions. Mn porphyrin (MnP)-based redox active drugs have demonstrated differential effects on cancer and normal tissues in experimental animals that lead to protection of normal tissues and radio- and chemo-sensitization of cancers...
April 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/28454035/occurrence-and-genetic-diversity-of-cryptosporidium-and-giardia-in-urban-wastewater-treatment-plants-in-north-eastern-spain
#9
Ana Ramo, Emilio Del Cacho, Caridad Sánchez-Acedo, Joaquín Quílez
This study was designed to investigate the presence and removal efficiency of Cryptosporidium and Giardia in wastewater treatment plants at the 20 most populated towns in Aragón (north-eastern Spain). Samples of influent and effluent wastewater and dewatered sewage sludge were collected seasonally from 23 plants and processed according to USEPA Method 1623. All samples from raw and treated wastewater tested positive for Giardia, at an average concentration of 3247±2039cysts/l and 50±28cysts/l, respectively...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453992/salinomycin-overcomes-radioresistance-in-nasopharyngeal-carcinoma-cells-by-inhibiting-nrf2-level-and-promoting-ros-generation
#10
Gong Zhang, Wenjun Wang, Chunxiao Yao, Jinjin Ren, Shuping Zhang, Muyuan Han
Radiotherapy is the most important treatment for nasopharyngeal carcinoma (NPC). Radioresistant cancer cells have been shown to potentially result in residual disease that can lead to recurrence and metastasis. Salinomycin (SAL) has been identified as a promising anticancer drug during chemical screening, but it is unclear whether SAL plays a role in radioresistance. The nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial regulator of the cellular antioxidant system. There are currently numerous data indicating that Nrf2 has an important role in cancer radioresistance...
April 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28453981/facile-synthesis-of-flower-like-ag3vo4-bi2wo6-heterojunction-with-enhanced-visible-light-photocatalytic-activity
#11
Shijie Li, Shiwei Hu, Wei Jiang, Yu Liu, Jianshe Liu, Zhaohui Wang
Constructing novel semiconductor heterojunctions is one of the most significant approaches to improving the photocatalytic performance of a photocatalyst. Herein, the Ag3VO4/Bi2WO6 heterojunction was prepared through in-situ anchoring Ag3VO4 nanoparticles (size: ∼21nm) on the surface of Bi2WO6 microflowers (diameter: 2.5-4.5μm) by a facile deposition route. The photocatalytic activity of these heterojunctions were studied by decomposing cationic dye rhodamine B (RhB), anionic dye methyl orange (MO) and neutral para-chlorophenol (4-CP) under visible light irradiation (λ>400nm)...
April 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28453703/heart-dose-exposure-as-prognostic-marker-after-radiotherapy-for-resectable-stage-iiia-b-non-small-cell-lung-cancer-secondary-analysis-of-a-randomized-trial
#12
M Guberina, W Eberhardt, M Stuschke, T Gauler, F Heinzelmann, D Cheufou, M Kimmich, G Friedel, H Schmidberger, K Darwiche, V Jendrossek, M Schuler, G Stamatis, C Pöttgen
Background: Heart exposure to ionizing irradiation can cause ischaemic heart disease. The partial heart volume receiving ≥5 Gy (heartV5) was supposed to be an independent prognostic factor for survival after radiochemotherapy for locally advanced non-small-cell lung cancer (NSCLC). But validation of the latter hypothesis is needed under the concurrent risks of lung cancer patients. Patients and methods: The ESPATUE phase III trial recruited patients with potentially operable IIIA(N2)/selected IIIB NSCLC between 01/2004 and 01/2013...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453388/susceptibility-of-atm-deficient-pancreatic-cancer-cells-to-radiation
#13
Michael Ayars, James Eshleman, Michael Goggins
Ataxia telangiectasia mutated (ATM) is inactivated in a significant minority of pancreatic ductal adenocarcinomas and may be predictor of treatment response. We determined if ATM deficiency renders pancreatic cancer cells more sensitive to fractionated radiation or commonly used chemotherapeutics. ATM expression was knocked down in three pancreatic cancer cell lines using ATM-targeting shRNA. Isogenic cell lines were tested for sensitivity to several chemotherapeutic agents and radiation. DNA repair kinetics were analyzed in irradiated cells using the comet assay...
April 28, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28449469/cd90-positive-cells-exhibit-aggressive-radioresistance-in-esophageal-squamous-cell-carcinoma
#14
Yuandong Wang, Chi Zhang, Hongcheng Zhu, Junwei Tang, Shu Zhang, Jinhua Luo, Xinchen Sun
BACKGROUND: Cancer stem cells (CSCs) are widely abundant and considered to be an important factor in therapy resistance. They are also promising potential targets for conquering tumors. We explored the effects of radiation on stem cell-like tumor cells via the candidate marker CD90 to provide new ideas for the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). METHODS: We constructed CD90 overexpression ESCC cells by lentiviral transfection and observed differences of toxicity, proliferation, clone number, apoptosis, migration, invasion, and in vivo tumor formation after irradiation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449224/validation-of-omi-uv-satellite-data-using-spectral-and-broadband-surface-based-measurements-at-a-queensland-site
#15
Mustapha A Jebar, Alfio V Parisi, Nathan J Downs, Joanna F Turner
This research reconstructed and validated the broadband UVA irradiances derived from discrete spectral irradiance data retrieved from the Ozone Monitoring Instrument (OMI) satellite from 1 January to 31 December 2009. OMI data at solar noon was compared to ground based spectral irradiances at Toowoomba (27°36' S 151°55' E), Australia at 310, 324 and 380 nm for both cloud free and all sky conditions. There was a strong relationship between the ground based UV spectroradiometer data and satellite based measurements with an R(2) of 0...
April 27, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28448901/tailoring-of-tio2-films-by-h2so4-treatment-and-uv-irradiation-to-improve-anticoagulant-ability-and-endothelial-cell-compatibility
#16
Yuzhen Liao, Linhua Li, Jiang Chen, Ping Yang, Ansha Zhao, Hong Sun, Nan Huang
Surfaces with dual functions that simultaneously exhibit good anticoagulant ability and endothelial cell (EC) compatibility are desirable for blood contact materials. However, these dual functions have rarely been achieved by inorganic materials. In this study, titanium dioxide (TiO2) films were treated by sulphuric acid (H2SO4) and ultraviolet (UV) irradiation successively (TiO2H2SO4-UV), resulting in good anticoagulant ability and EC compatibility simultaneously. We found that UV irradiation improved the anticoagulant ability of TiO2 films significantly while enhancing EC compatibility, though not significantly...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28448832/fabrication-of-a-novel-z-scheme-g-c3n4-bi4o7-heterojunction-photocatalyst-with-enhanced-visible-light-driven-activity-toward-organic-pollutants
#17
Meng Sun, Yu Wang, Yu Shao, Yunhui He, Qi Zeng, Huikai Liang, Tao Yan, Bin Du
In this work, highly efficient g-C3N4/Bi4O7 heterojunction photocatalysts have been successfully fabricated by a facile method. Compared with the bare photocatalysts, the obtained g-C3N4/Bi4O7 hybrid photocatalysts exhibited efficient degradation activity toward methylene blue (MB), phenol, rhodamine B (RhB), and bisphenol A (BPA) under visible light irradiation. The influences of different g-C3N4 contents on the photocatalytic efficiency of the hybrid photocatalysts have been investigated. The results revealed that the g-C3N4/Bi4O7 with g-C3N4 mass ratio of 30% exhibited the best photocatalytic activity...
April 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448831/computer-simulations-analysis-for-determining-the-polarity-of-charge-generated-by-high-energy-electron-irradiation-of-a-thin-film
#18
Marek Malac, Simon Hettler, Misa Hayashida, Masahiro Kawasaki, Yuji Konyuba, Yoshi Okura, Hirofumi Iijima, Isamu Ishikawa, Marco Beleggia
Detailed simulations are necessary to correctly interpret the charge polarity of electron beam irradiated thin film patch. Relying on systematic simulations we provide guidelines and movies to interpret experimentally the polarity of the charged area, to be understood as the sign of the electrostatic potential developed under the beam with reference to a ground electrode. We discuss the two methods most frequently used to assess charge polarity: Fresnel imaging of the irradiated area and Thon rings analysis...
April 3, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28448828/note-on-in-situ-scanning-transmission-electron-microscopy-study-of-liquid-samples
#19
Nan Jiang
Liquid cell (scanning) transmission electron microscopy has been developed rapidly, using amorphous SiNx membranes as electron transparent windows. The current interpretations of electron beam effects are mainly based on radiolytic processes. In this note, additional effects of the electric field due to electron-beam irradiation are discussed. The electric field can be produced by the charge accumulation due to the emission of secondary and Auger electrons. Besides various beam-induced phenomena, such as nanoparticle precipitation and gas bubble formation and motion, two other effects need to be considered; one is the change of Gibbs free energy of nucleation and the other is the violation of Brownian motion due to ion drifting driven by the electric field...
April 19, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28448750/simultaneous-atrazine-degradation-and-e-coli-inactivation-by-simulated-solar-photo-fenton-like-process-using-persulfate
#20
Natalya Garkusheva, Galina Matafonova, Irina Tsenter, Sara Beck, Valeriy Batoev, Karl Linden
This work evaluated the feasibility of a photo-Fenton-like process using persulfate (PS) and ferrous iron (Fe(2+)) under simulated solar radiation for degrading the herbicide atrazine (ATZ, 6-Chloro-N-ethyl-N'-isopropyl-1,3,5-triazine-2,4-diamine) and inactivating E. coli. Milli Q water, lake water, and diluted wastewater effluents were spiked both simultaneously and separately with ATZ (4 mg/L) and E. coli (10(5) CFU/mL), and exposed to treatment. A method for determining the average irradiance throughout the water media in the UV(A+B) range of the Xe lamp emission was developed for bench-scale experiments...
April 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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