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https://www.readbyqxmd.com/read/28735527/fibroblast-activating-protein-%C3%AE-expression-in-squamous-cell-carcinoma-of-the-esophagus-in-primary-and-irradiated-tumors-the-use-of-archival-ffpe-material-for-molecular-techniques
#1
Renata Tabola, Magdalena Zaremba-Czogalla, Dagmara Baczynska, Roberto Cirocchi, Kamila Stach, Krzysztof Grabowski, Katarzyna Augoff
There are numerous reports suggesting that fibroblast activating protein-α (FAP-α) plays an important role in invasion of various tumor types. We studied the expression pattern of FAP-α in esophageal squamous cell carcinoma (ESCC) patients who had not been treated primarily and those who had received neoadjuvant radiochemotherapy. Our goal was to establish whether readily available tissue specimens fixed in formalin and stored in paraffin blocks for years might still be a source of FAP-α RNA for PCR analysis...
June 20, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735464/radiation-dose-reduction-in-thoracic-and-lumbar-spine-instrumentation-using-navigation-based-on-an-intraoperative-cone-beam-ct-imaging-system-a-prospective-randomized-clinical-trial
#2
Nathalie Pireau, Virginie Cordemans, Xavier Banse, Nadia Irda, Sébastien Lichtherte, Ludovic Kaminski
PURPOSE: Spine surgery still remains a challenge for every spine surgeon, aware of the potential serious outcomes of misplaced instrumentation. Though many studies have highlighted that using intraoperative cone beam CT imaging and navigation systems provides higher accuracy than conventional freehand methods for placement of pedicle screws in spine surgery, few studies are concerned about how to reduce radiation exposure for patients with the use of such technology. One of the main focuses of this study is based on the ALARA principle (as low as reasonably achievable)...
July 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28735236/oxidation-of-tris-2-chloroethyl-phosphate-in-aqueous-solution-by-uv-activated-peroxymonosulfate-kinetics-water-matrix-effects-degradation-products-and-reaction-pathways
#3
Xinxin Xu, Jing Chen, Ruijuan Qu, Zunyao Wang
The feasibility of UV-activated peroxymonosulfate (PMS) technology for the degradation of Tris (2-chloroethyl) phosphate (TCEP) in an aqueous solution was investigated in this study. The conditions of [PMS]0: [TCEP]0 = 20:1, T = 25 ± 2 °C and pH = 5.5 ± 0.5 cause a 94.6% removal of TCEP (1 mg L(-1)) after 30 min of Hg lamp irradiation. The effects of operating parameters (the oxidant doses, pH and presence of typical cations (Fe(3+), Cu(2+), Ni(2+), NH4(+)), anions (Cl(-), HCO3(-), NO3(-), HPO4(2-)) and humic acid (HA)) were evaluated...
July 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28735199/one-pot-synthesis-of-bismuth-silicate-heterostructures-with-tunable-morphology-and-excellent-visible-light-photodegradation-performances
#4
Kun-Le Jia, Jin Qu, Shu-Meng Hao, Fei An, Ya-Qiong Jing, Zhong-Zhen Yu
Construction of a heterostructure to prolong the life of electron-hole pairs is a very important approach to endow it with excellent photodegradation performances. Particularly, one-pot synthesis of heterostructures with the same component but different crystal structures to form a proper band gap is still challenging. Herein, bismuth silicate (BSO) heterostructures are synthesized using a one-pot hydrothermal approach without adding any other inorganic components. The crystal phase, morphology, surface state, and photochemical properties of the BSO materials are precisely tuned to fabricate two kinds of bismuth silicate heterostructures: rod-like Bi2SiO5/Bi12SiO20 and flower-like Bi2SiO5/Bi4Si3O12 heterostructures...
July 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28735175/cancer-cell-membrane-coated-biomimetic-platform-for-tumor-targeted-photodynamic-therapy-and-hypoxia-amplified-bioreductive-therapy
#5
Shi-Ying Li, Hong Cheng, Wen-Xiu Qiu, Lu Zhang, Shuang-Shuang Wan, Jing-Yue Zeng, Xian-Zheng Zhang
Modulating tumor microenvironment to amplify the therapeutic efficiency would be a novel strategy for effective cancer treatment. In this work, based on the TPZ-loaded porphyrinic metal organic framework PCN-224 (PCN stands for porous coordination network), a cancer cell membrane-coated nanoplatform (TPZ@PCN@Mem) was fabricated for tumor targeted PDT and the successively resulting hypoxia-amplified bioreductive therapy. After administration, TPZ@PCN@Mem exhibited the selective accumulation and long-term retention at tumor tissue due to the immune escape and homologous targeting endowed by the cancer membrane coating...
July 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28734822/icotinib-versus-whole-brain-irradiation-in-patients-with-egfr-mutant-non-small-cell-lung-cancer-and-multiple-brain-metastases-brain-a-multicentre-phase-3-open-label-parallel-randomised-controlled-trial
#6
Jin-Ji Yang, Caicun Zhou, Yisheng Huang, Jifeng Feng, Sun Lu, Yong Song, Cheng Huang, Gang Wu, Li Zhang, Ying Cheng, Chengping Hu, Gongyan Chen, Li Zhang, Xiaoqing Liu, Hong Hong Yan, Fen Lai Tan, Wenzhao Zhong, Yi-Long Wu
BACKGROUND: For patients with non-small-cell lung cancer (NSCLC) and multiple brain metastases, whole-brain irradiation (WBI) is a standard-of-care treatment, but its effects on neurocognition are complex and concerning. We compared the efficacy of an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), icotinib, versus WBI with or without chemotherapy in a phase 3 trial of patients with EGFR-mutant NSCLC and multiple brain metastases. METHODS: We did a multicentre, open-label, parallel randomised controlled trial (BRAIN) at 17 hospitals in China...
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28734747/retroperitoneal-fibrosis-associated-with-immunoglobulin-g4-related-disease-in-the-differential-diagnosis-in-retroperitoneal-tumors-case-report
#7
Gabriela Ruiz Mar, Óscar E Cárdenas Serrano, Jorge Roldan García, A Cañavera-Constantino, Víctor M Menéndez Trejo, Óscar Chapa Azuela
The patient was a 55-year-old woman with a 4-month history of pain in left flank that irradiated to the lumbar region. Computed tomography revealed a cystic tumor in the retroperitoneal region that compresses the ureter and left renal pelvis in contact with pancreatic body and tail. Surgery was performed and the definitive pathological report diagnosed nodular retroperitoneal fibrosis associated with IgG4; Ki67-positive in germinal centers (5%) and IgG4-positive (40 plasma cells in 3 fields of 40x) by immunohistochemistry...
July 19, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28734286/communication-light-driven-remote-control-of-microgels-size-in-the-presence-of-photosensitive-surfactant-complete-phase-diagram
#8
Selina Schimka, Yulia D Gordievskaya, Nino Lomadze, Maren Lehmann, Regine von Klitzing, Artem M Rumyantsev, Elena Yu Kramarenko, Svetlana Santer
Here we report on a light triggered remote control of microgel size in the presence of photosensitive surfactant. The hydrophobic tail of the cationic surfactant contains azobenzene group that undergoes a reversible photo-isomerization reaction from a trans- to a cis-state accompanied by a change in the hydrophobicity of the surfactant. We have investigated light assisted behaviour and the complex formation of the microgels with azobenzene containing surfactant over the broad concentrational range starting far below and exceeding several times of the critical micelle concentration (CMC)...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734216/releasing-of-hexabromocyclododecanes-from-expanded-polystyrenes-in-seawater-field-and-laboratory-experiments
#9
Manviri Rani, Won Joon Shim, Mi Jang, Gi Myung Han, Sang Hee Hong
Expanded polystyrene (EPS) is a major component of marine debris globally. Recently, hazardous hexabromocyclododecanes (HBCDDs) were detected in EPS buoys used for aquaculture farming. Subsequently, enrichment of HBCDDs was found in nearby marine sediments and mussels growing on EPS buoys. It was suspected that EPS buoys and their debris might be sources of HBCDDs. To confirm this, the release of HBCDDs from EPS spherules detached from a buoy to seawater was investigated under field (open sea surface and closed outdoor chambers with sun exposure and in the dark) and laboratory (particle-size) conditions...
July 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28733678/physiological-and-transcriptome-analysis-of-he-ne-laser-pretreated-wheat-seedlings-in-response-to-drought-stress
#10
Zongbo Qiu, Mengmeng Yuan, Yanyan He, Yongfang Li, Liang Zhang
Drought stress is a serious problem worldwide that reduces crop productivity. The laser has been shown to play a positive physiological role in enhancing plant seedlings tolerance to various abiotic stresses. However, little information is available about the molecular mechanism of He-Ne laser irradiation induced physiological changes for wheat adapting to drought conditions. Here, we performed a large-scale transcriptome sequencing to determine the molecular roles of He-Ne laser pretreated wheat seedlings under drought stress...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733529/immunotherapy-of-wap-tnp-mice-with-early-stage-mammary-gland-tumors
#11
Michael Bruns, Wolfgang Deppert
The SV40 transgenic BALB/c mouse based WAP-T/WAP-TNP model for triple-negative breast cancer allows the analysis of parameters influencing immunotherapeutic approaches. Except for WAP-TNP tumors expressing the immune-dominant LCMV NP-epitope within SV40 T-antigen (T-AgNP) which is not expressed by T-Ag of WAP-T tumors, the tumors are extremely similar. Comparative anti-PD1/PD-L1 immunotherapy of WAP-T and WAP-TNP mice supported the hypothesis that the immunogenicity of tumor antigen T-cell epitopes strongly influences the success of immune checkpoint blockade therapy, with highly immunogenic T-cell epitopes favoring rapid CTL exhaustion...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733115/dose-distribution-characteristic-study-of-the-rotating-gamma-knife-rgk-by-using-the-geometry-analytic-method
#12
Fen Chen, Jun-Wen Shi, Zhao-Sheng Yin, Ying Peng, Yee-Min Jen, Jia-Ming Wu
The purpose of this study was to realize the processing of dose distribution of RGK at the treatment isocenter at any gantry rotational angle by using an analytic geometry method to avoid inadequate arc therapy angles when implementing the treatment plan. Gaf chromic film was used for dose evaluation. A calibration curve was first obtained using linear accelerator irradiation. The 50% dose relative to the central axis at fixed gantry angles at the x-, y- and z-axes was obtained using Gaf chromic film and was compared to the analytic geometry method...
July 18, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28733054/clinical-and-diagnosis-characteristics-of-breast-cancers-in-women-with-a-history-of-radiotherapy-in-the-first-30years-of-life-a-french-multicentre-cohort-study
#13
C Demoor-Goldschmidt, S Supiot, O Oberlin, S Helfre, C Vigneron, V Brillaud-Meflah, V Bernier, A Laprie, A Ducassou, L Claude, M A Mahé, F de Vathaire
PURPOSE: Irradiation (>3Gy) to the breast or axillae before 30years of age increases the risk of secondary breast cancer (SBC). The purpose of this article is to describe the clinical characteristics of SBC and the way of diagnosis in young women (before the age of national screening) in France who had received previous radiotherapy for a childhood or a young adulthood cancer. PATIENTS AND METHODS: This retrospective, multicentre study reviewed the medical records of women with SBC before the age of the national screening who had received irradiation (≥3Gy) on part or all of the breast before 30years of age, for any type of tumour except BC...
July 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28733021/sonochemical-synthesis-and-structural-characterization-of-a-new-nanostructured-co-ii-supramolecular-coordination-polymer-with-lewis-base-sites-as-a-new-catalyst-for-knoevenagel-condensation
#14
Monika Joharian, Sedigheh Abedi, Ali Morsali
A new Co(II) mixed-ligand coordination supramolecular polymer with composition [Co2(ppda)(4-bpdh)2(NO3)2]n (1) (where, ppda=p-phenylenediacrylic acid, 4-bpdh=2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) was synthesized using solvothermal, mechanochemical and sonochemical methods. Compound 1 and the new nanostructure have been characterized by single-crystal X-ray, infrared spectroscopy (IR), powder X-ray diffraction (PXRD) analysis and scanning electron microscopy (SEM). The thermal stability of compound 1 was also studied by thermal gravimetric analysis (TGA)...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733019/sonochemical-synthesis-of-hydrogenated-amorphous-silicon-nanoparticles-from-liquid-trisilane-at-ambient-temperature-and-pressure
#15
Andrew P Cádiz Bedini, Benjamin Klingebiel, Martina Luysberg, Reinhard Carius
Silicon nanoparticles (Si-NPs) are increasing in relevance in diverse fields of scientific and nanotechnological inquiry, where currently some of the most important areas of research involve energy storage and biomedical applications. The present article is concerned with a curious and scalable method for the preparation of discrete, unoxidized, hydrogenated, and amorphous Si-NPs of tunable size in the range of 1.5-50nm. Using ultrasound generated with a conventional ultrasonic horn, the "fusion" of Si-NPs is demonstrated at ambient temperature and pressure by sonicating solutions containing readily available, semiconductor-grade purity trisilane (Si3H8)...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733017/combined-sonochemical-and-short-wavelength-uv-degradation-of-hydrophobic-perfluorinated-compounds
#16
Kazuhiko Sekiguchi, Takahisa Kudo, Kenshi Sankoda
Perfluorochemicals (PFCs), which are common in the aquatic environment, are toxic substances that have high chemical and heat resistance because of their strong C-F bonds. We investigated the effect of ultrasonication and short-wavelength UV irradiation on the degradation of perfluorooctane, perfluoropropionic acid, and perfluorooctanoic acid, which are examples of hydrophobic, hydrophilic, and intermediate PFCs, respectively. The results confirmed that ultrasonication was more effective for decomposing hydrophobic PFCs and UV irradiation was more effective for decomposing hydrophilic PFCs...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733015/ultrasonic-assisted-synthesis-of-polyvinyl-alcohol-phytic-acid-polymer-film-and-its-thermal-stability-mechanical-properties-and-surface-resistivity
#17
Jihui Li, Yongshen Li, Yunna Song, Shuai Niu, Ning Li
In this paper, polyvinyl alcohol/phytic acid polymer (PVA/PA polymer) was synthesized through esterification reaction of PVA and PA in the case of acidity and ultrasound irradiation and characterized, and PVA/PA polymer film was prepared by PVA/PA polymer and characterized, and the influence of dosage of PA on the thermal stability, mechanical properties and surface resistivity of PVA/PA polymer film were researched, and the influence of sonication time on the mechanical properties of PVA/PA polymer film was investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733013/photoluminescence-electrochemical-behavior-and-photocatalytic-activities-of-cobalt-ii-coordination-polymer-nanostructures-synthesized-by-sonochemical-process
#18
Jing-Wang Cui, Yue-Hua Li, Ling-Yan Zhao, Guang-Hua Cui
Nanostructures of a new Co(II) coordination polymer (CP), [Co(Hbibp)(nbta)]n (1), (bibp=4,4'-bis(1-imidazolyl)biphenyl, H3nbta=5-nitro-1,2,3-benzenetricarboxylic acid) was synthesized by a sonochemical method. The nano-sized CP 1 was characterized by elemental analysis, IR spectroscopy, X-ray powder diffraction and scanning electron microscopy (SEM). Structural analysis show that CP 1 exhibits a 1D chain structure with a 3-connected SP 1-periodic net (4,4)(0,2) topology, which can be further extended into a 2D supramolecular layer by the NH⋯O hydrogen bond interactions...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733012/ultrasound-promoted-copper-catalyzed-synthesis-of-bis-arylselanyl-chrysin-derivatives-with-boosted-antioxidant-and-anticancer-activities
#19
Sergio F Fonseca, Nathalia B Padilha, Samuel Thurow, Juliano A Roehrs, Lucielli Savegnago, Maurice N de Souza, Mariana G Fronza, Tiago Collares, Julieti Buss, Fabiana K Seixas, Diego Alves, Eder J Lenardão
Herein we report the use of ultrasonic irradiation (US) in the synthesis of six new semi-synthetic selenium-containing chrysin derivatives by a simple and effective methodology utilizing CuI as catalyst, in good to excellent yields (60-89%). It was observed that US accelerates the reaction compared to conventional heating with excellent selectivity for diselenylated products. Compounds were tested for their antioxidant and anticancer activities in vitro and it was observed that the presence of selenium in the A-ring of chrysin enhanced both antioxidant and anticancer properties...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28733011/rapid-preparation-of-high-electrochemical-performance-lifepo4-c-composite-cathode-material-with-an-ultrasonic-intensified-micro-impinging-jetting-reactor
#20
Bin Dong, Xiani Huang, Xiaogang Yang, Guang Li, Lan Xia, George Chen
A joint chemical reactor system referred to as an ultrasonic-intensified micro-impinging jetting reactor (UIJR), which possesses the feature of fast micro-mixing, was proposed and has been employed for rapid preparation of FePO4 particles that are amalgamated by nanoscale primary crystals. As one of the important precursors for the fabrication of lithium iron phosphate cathode, the properties of FePO4 nano particles significantly affect the performance of the lithium iron phosphate cathode. Thus, the effects of joint use of impinging stream and ultrasonic irradiation on the formation of mesoporous structure of FePO4 nano precursor particles and the electrochemical properties of amalgamated LiFePO4/C have been investigated...
November 2017: Ultrasonics Sonochemistry
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