keyword
https://read.qxmd.com/read/38461908/pyroptosis-in-myocardial-ischemia-reperfusion-and-its-therapeutic-implications
#21
REVIEW
Yin Liu, Xi Li, Tingting Sun, Tao Li, Qian Li
Ischemic heart disease, a prevalent cardiovascular disease with global significance, is associated with substantial morbidity. Timely and successful reperfusion is crucial for reducing infarct size and enhancing clinical outcomes. However, reperfusion may induce additional myocardium injury, manifesting as myocardial ischemia/reperfusion (MI/R) injury. Pyroptosis is a regulated cell death pathway, the signaling pathway of which is activated during MI/R injury. In this process, the inflammasomes are triggered, initiating the cleavage of gasdermin proteins and pro-interleukins, which results in the formation of membrane pores and the maturation and secretion of inflammatory cytokines...
March 8, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38461460/poroelastic-modelling-of-brain-tissue-swelling-and-decompressive-craniectomy-treatment-in-ischaemic-stroke
#22
JOURNAL ARTICLE
Aina Najwa Nadzri, Nik Abdullah Nik Mohamed, Stephen J Payne, Mohd Jamil Mohamed Mokhtarudin
Brain oedema or tissue swelling that develops after ischaemic stroke can cause detrimental effects, including brain herniation and increased intracranial pressure (ICP). These effects can be reduced by performing a decompressive craniectomy (DC) operation, in which a portion of the skull is removed to allow swollen brain tissue to expand outside the skull. In this study, a poroelastic model is used to investigate the effect of brain ischaemic infarct size and location on the severity of brain tissue swelling...
March 10, 2024: Computer Methods in Biomechanics and Biomedical Engineering
https://read.qxmd.com/read/38457313/reduction-of-left-ventricular-diastolic-pressure-as-a-key-regulator-of-infarct-coronary-flow-under-mechanical-left-ventricular-support
#23
JOURNAL ARTICLE
Tomoki Sakata, Spyros A Mavropoulos, Renata Mazurek, Francisco J Romeo, Anjali J Ravichandran, Jonas M Marx, Taro Kariya, Kiyotake Ishikawa
Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Acute mechanical left ventricular (LV) support has been suggested to improve infarct tissue perfusion. However, its regulatory mechanism remains unclear. We investigated the physiological mechanisms in six Yorkshire pigs, which were subjected to 90-min balloon occlusion of the left anterior descending artery. During the acute reperfusion phase, LV support using an Impella heart pump was initiated. LV pressure, coronary flow and pressure of the infarct artery were simultaneously recorded to evaluate the impact of LV support on coronary physiology...
March 8, 2024: Journal of Physiology
https://read.qxmd.com/read/38452414/fisetin-alleviates-cerebral-ischemia-reperfusion-injury-by-regulating-sirt1-foxc1-ubqln1-pathway-mediated-proteostasis
#24
JOURNAL ARTICLE
Xunhu Gu, Yuqin Xie, Qian Cao, Zhuo Hou, Yan Zhang, Wei Wang
BACKGROUND: Cerebral ischemia/reperfusion injury (IRI) is pathologically associated with protein damage. The flavonoid fisetin has good therapeutic effects on cerebral IRI. However, the role of fisetin in regulating protein damage during cerebral IRI development remains unclear. This study investigated the pharmacological effects of fisetin on protein damage during cerebral IRI progression and defined the underlying mechanism of action. METHODS: In vivo and in vitro models of cerebral IRI were established by middle cerebral artery occlusion/reperfusion (MACO/R) and oxygen-glucose deprivation/reperfusion (OGD/R) treatment, respectively...
March 6, 2024: International Immunopharmacology
https://read.qxmd.com/read/38450510/prior-exposure-to-experimental-preeclampsia-increases-atherosclerotic-plaque-inflammation-in-atherogenic-mice
#25
JOURNAL ARTICLE
Lauren A Biwer, Joshua J Man, Nicholas D Camarda, Brigett V Carvajal, S Ananth Karumanchi, Iris Z Jaffe
BACKGROUND: Women with a history of preeclampsia have evidence of premature atherosclerosis and increased risk of myocardial infarction and stroke compared with women who had a normotensive pregnancy. Whether this is due to common risk factors or a direct impact of prior preeclampsia exposure has never been tested in a mouse atherosclerosis model. METHODS: Pregnant LDLR-KO (low-density lipoprotein receptor knockout; n=35) female mice were randomized in midgestation to sFlt1 (soluble fms-like tyrosine kinase 1)-expressing adenovirus or identical control adenovirus...
March 7, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38450367/inflammation-as-the-nexus-exploring-the-link-between-acute-myocardial-infarction-and-chronic-obstructive-pulmonary-disease
#26
REVIEW
Eloise Marriott, Aran Singanayagam, Juma El-Awaisi
Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38445467/inflammatory-type-focal-cerebral-arteriopathy-of-the-posterior-circulation-in-children-a-comparative-cohort-study
#27
JOURNAL ARTICLE
Nedelina Slavova, Robin Muenger, Iciar Sanchez-Albisua, Maria Regényi, Gabriela Oesch, Joël Fluss, Annette Hackenberg, Sébastien Lebon, Oliver Maier, Alexandre N Datta, Sandra Bigi, Sebastian Grunt, Maja Steinlin
BACKGROUND: Inflammatory type focal cerebral arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized, and the focal cerebral arteriopathy severity score (FCASS) reflects the severity of the disease. We identified cases of FCA-i in the posterior circulation (PC) and adapted the FCASS to describe these cases. METHODS: In this comparative cohort study, patients from the Swiss NeuroPaediatric Stroke Registry with ischemic stroke due to FCA-i between January 2000 and December 2018 were analyzed...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38445387/a-novel-intracoronary-hypothermia-device-reduces-myocardial-reperfusion-injury-in-pigs
#28
JOURNAL ARTICLE
Zhiqiang Pei, Jin Qiu, Yongchao Zhao, Shuai Song, Rui Wang, Wei Luo, Xingxing Cai, Bin Liu, Han Chen, Jiasheng Yin, Xinyu Weng, Yizhe Wu, Chenguang Li, Li Shen, Junbo Ge
BACKGROUND: Hypothermia therapy has been suggested to attenuate myocardial necrosis; however, the clinical implementation as a valid therapeutic strategy has failed, and new approaches are needed to translate into clinical applications. This study aimed to assess the feasibility, safety, and efficacy of a novel selective intracoronary hypothermia (SICH) device in mitigating myocardial reperfusion injury. METHODS: This study comprised two phases. The first phase of the SICH was performed in a normal porcine model for 30 minutes ( n = 5) to evaluate its feasibility...
March 6, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38444592/superb-micro-vascular-imaging-in-prenatal-ultrasound-diagnosis-of-placental-infarction-a-case-report
#29
Yun-Zhu Wu, Qing-Yun Song
BACKGROUND: Placental infarction refers to a localized area of ischemic villous necrosis resulting from the interruption of maternal blood flow to the intervillous space, which can be attributed to spasm, stenosis, or occlusion of the decidual spiral artery caused by systemic or localized maternal vascular disease. The presence of large placental infarcts may pose significant risks to fetal well-being, including intrauterine growth retardation, fetal distress, and even fetal demise. Although placental infarction is commonly identified during postnatal pathological examinations, its prenatal diagnosis through ultrasound remains challenging and has been rarely reported...
2024: International Journal of Women's Health
https://read.qxmd.com/read/38444254/a-novel-micropeptide-slitharin-exerts-cardioprotective-effects-in-myocardial-infarction
#30
JOURNAL ARTICLE
Ahmed G E Ibrahim, Alessandra Ciullo, Shukuro Yamaguchi, Chang Li, Travis Antes, Xaviar Jones, Liang Li, Ramachandran Murali, Innokentiy Maslennikov, Niveda Sundararaman, Daniel Soetkamp, Eugenio Cingolani, Jennifer Van Eyk, Eduardo Marbán
PURPOSE: Micropeptides are an emerging class of proteins that play critical roles in cell signaling. Here, we describe the discovery of a novel micropeptide, dubbed slitharin (Slt), in conditioned media from Cardiosphere-derived cells (CDCs), a therapeutic cardiac stromal cell type. EXPERIMENTAL DESIGN: We performed mass spectrometry of peptide-enriched fractions from the conditioned media of CDCs and a therapeutically inert cell type (human dermal fibrobasts). We then evaluated the therapeutic capacity of the candidate peptide using an in vitro model of cardiomyocyte injury and a rat model of myocardial infarction...
March 5, 2024: Proteomics. Clinical Applications
https://read.qxmd.com/read/38443844/association-between-serum-triglycerides-and-stroke-type-severity-and-prognosis-analysis-in-6558-patients
#31
JOURNAL ARTICLE
Naveed Akhtar, Rajvir Singh, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Ty Uy, Sarah Treit, Ashfaq Shuaib
BACKGROUND AND OBJECTIVES: Hypertriglyceridemia (HT) may increase the risk of stroke. Limited studies have shown that stroke severity and infarction size are smaller in patients with HT. We explored the relationship between triglyceride levels and stroke risk factors, severity and outcome in a large prospective database. DESIGN: Prospective Cross-sectional study. SETTING: We retrospectively interrogated the Qatar Stroke Database in all patients admitted between 2014-2022 with acute ischemic stroke and evaluated the relationship between triglyceride, diabetes, stroke severity (measured on NIHSS), stroke type (TOAST classification) and the short- (mRS at 90 days) and long-term outcomes (MACE at 1 year) in patients with HT...
March 5, 2024: BMC Neurology
https://read.qxmd.com/read/38443457/quantification-of-myocardial-scar-of-different-etiology-using-dark-and-bright-blood-late-gadolinium-enhancement-cardiovascular-magnetic-resonance
#32
JOURNAL ARTICLE
Lamis Jada, Robert J Holtackers, Bibi Martens, Hedwig M J M Nies, Caroline M Van De Heyning, Rene M Botnar, Joachim E Wildberger, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
Dark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas of ischemic scar compared to standard bright-blood LGE. Recently, the performance of various semi-automated quantification methods has been evaluated for the assessment of infarct size using both dark-blood LGE and conventional bright-blood LGE with histopathology as a reference standard. However, the impact of this sequence on different quantification strategies in vivo remains uncertain. In this study, various semi-automated scar quantification methods were evaluated for a range of different ischemic and non-ischemic pathologies encountered in clinical practice...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38441860/targeting-pi3k-akt-in-cerebral-ischemia-reperfusion-injury-alleviation-from-signaling-networks-to-targeted-therapy
#33
REVIEW
Ting Zheng, Taotao Jiang, Hongxiang Ma, Yanping Zhu, Manxia Wang
Ischemia/reperfusion (I/R) injury is a pathological event that results in reperfusion due to low blood flow to an organ. Cerebral ischemia is a common cerebrovascular disease with high mortality, and reperfusion is the current standard intervention. However, reperfusion may further induce cellular damage and dysfunction known as cerebral ischemia/reperfusion injury (CIRI). Currently, strategies for the clinical management of CIRI are limited, necessitating the exploration of novel and efficacious treatment modalities for the benefit of patients...
March 5, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38440926/acoustic-activation-imaging-with-intravenous-perfluoropropane-nanodroplets-results-in-selective-bioactivation-of-the-risk-area
#34
JOURNAL ARTICLE
Shouqiang Li, Cheng Chen, John Lof, Elizabeth A Stolze, Jiri Sklenar, Xucai Chen, John J Pacella, Flordeliza S Villanueva, Terry O Matsunaga, E Carr Everbach, Stanley J Radio, Sherry N Westphal, Sruti Shiva, Feng Xie, Xiaoping Leng, Thomas R Porter
BACKGROUND: Acoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ). OBJECTIVE: We hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region...
March 5, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38439960/trifluoperazine-regulates-blood-brain-barrier-permeability-via-the-mlck-p-mlc-pathway-to-promote-ischemic-stroke-recovery
#35
JOURNAL ARTICLE
Wentao Zhang, Sisi Chen, Bin Ma, Yingmei Ding, Xiaofen Liu, Caijun He, Biao Wang, Mei Yuan
Blood-brain barrier (BBB) disruption following ischemic stroke (IS) can induce significant aftereffects. Elevated calmodulin (CaM) expression following stroke causes calcium overload-a key contributor to BBB collapse. Trifluoperazine (TFP), a CaM inhibitor, reduces CaM overexpression following IS. However, it remains unclear whether TFP participates in BBB repair after IS. We administered TFP to mice subjected to middle cerebral artery occlusion (MCAO) and bEnd.3 cells subjected to oxygen-glucose deprivation (OGD)...
March 15, 2024: IScience
https://read.qxmd.com/read/38435069/organic-pollutant-exposure-and-ckd-a-chronic-renal-insufficiency-cohort-pilot-study
#36
JOURNAL ARTICLE
David M Charytan, Wenbo Wu, Mengling Liu, Zhong-Min Li, Kurunthachalam Kannan, Leonardo Trasande, Vineet Kumar Pal, Sunmi Lee, Howard Trachtman
RATIONALE & OBJECTIVE: This study aimed to assess the effect of exposure to organic pollutants in adults with chronic kidney disease (CKD). STUDY DESIGN: This was a cross-sectional and longitudinal analysis. SETTING AND PARTICIPANTS: Forty adults enrolled in the Chronic Renal Insufficiency Cohort (CRIC). EXPOSURES: Exposure at baseline and longitudinally to various organic chemical pollutants. OUTCOMES: The outcomes were as follows: death; composite of congestive heart failure, myocardial infarction, and stroke; event-free survival from kidney failure or ≥50% decline in estimated glomerular filtration rate (eGFR); and longitudinal trajectory of eGFR...
March 2024: Kidney medicine
https://read.qxmd.com/read/38434034/transplantation-of-induced-pluripotent-stem-cells-derived-cardiomyocytes-combined-with-modified-taohong-siwu-decoction-improved-heart-repair-after-myocardial-infarction
#37
JOURNAL ARTICLE
Zhi-Rong Luo, Wan-Ting Meng, Han Li, Yu Wang, Ya-Chao Wang, Yue Zhao, Ping-Ping Lu, Yuan Yuan, Wei Huang, Hai-Dong Guo
OBJECTIVE: This study aimed to study whether modified Taohong Siwu decoction (MTHSWD) combined with human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs) transplantation can promote cardiac function in myocardial infarction (MI) nude mouse model and explore its possible mechanism. METHODS: The MI mouse model was established by the ligation of left anterior descending coronary artery. After 4 weeks of gavage of MTHSWD combined with iPS-CMs transplantation, the changes in heart function of mice were examined by echocardiography...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38431078/impact-of-late-gadolinium-enhancement-image-resolution-on-neural-network-based-automatic-scar-segmentation-in-cardiovascular-magnetic-resonance-imaging
#38
JOURNAL ARTICLE
Tobias Hoh, Isabel Margolis, Jonathan Weine, Thomas Joyce, Robert Manka, Miriam Weisskopf, Nikola Cesarovic, Maximilian Fuetterer, Sebastian Kozerke
BACKGROUND: Automatic myocardial scar segmentation from late gadolinium enhancement (LGE) images using neural networks promises an alternative to time-consuming and observer-dependent semi-automatic approaches. However, alterations in data acquisition, reconstruction as well as post-processing may compromise network performance. The objective of the present work was to systematically assess network performance degradation due to a mismatch of point-spread function between training and testing data...
February 29, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38430992/hypertension-microvascular-obstruction-and-infarct-size-in-patients-with-stemi-undergoing-pci-pooled-analysis-from-7-cardiac-magnetic-resonance-imaging-studies
#39
JOURNAL ARTICLE
Ghazaleh Mehdipoor, Björn Redfors, Shmuel Chen, Fotios Gkargkoulas, Zixuan Zhang, Manesh R Patel, Christopher B Granger, E Magnus Ohman, Akiko Maehara, Ingo Eitel, Ori Ben-Yehuda, Suzanne de Waha-Thiele, Holger Thiele, Gregg W Stone
INTRODUCTION: Mortality after ST-segment elevation myocardial infarction (STEMI) is increased in patients with hypertension. The mechanisms underlying this association are uncertain. We sought to investigate whether patients with STEMI and prior hypertension have greater microvascular obstruction (MVO) and infarct size (IS) compared with those without hypertension. METHODS: We pooled individual patient data from 7 randomized trials of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) in whom cardiac magnetic resonance imaging was performed within 1 month after reperfusion...
February 29, 2024: American Heart Journal
https://read.qxmd.com/read/38430148/effect-of-mvf-combined-with-fes-on-limb-function-recovery-and-fine-function-rehabilitation-of-hemiplegic-patients-after-aci
#40
JOURNAL ARTICLE
Peng Li, Hui Xin, Xinjie Zhang, Xiuli Li, Lihui Dou, Guiling Wang, Yan Li
BACKGROUND: This study assesses the efficacy of mirror visual feedback (MVF) combined with functional electrical stimulation (FES) in rehabilitating limb function and fine motor skills in hemiplegic patients after acute cerebral infarction (ACI). Given the limited research in this area, this study aims to provide insights into innovative rehabilitation techniques. METHODS: A randomized controlled trial was conducted on 106 post-ACI hemiplegic patients, split into two groups of 53 each...
March 1, 2024: Alternative Therapies in Health and Medicine
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