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Glycerophosphocholine

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https://www.readbyqxmd.com/read/29315663/circulating-25-hydroxyvitamin-d-nasopharyngeal-airway-metabolome-and-bronchiolitis-severity
#1
Kohei Hasegawa, Christopher J Stewart, Juan C Celedón, Jonathan M Mansbach, Courtney Tierney, Carlos A Camargo
Low circulating 25-hydroxyvitamin D (25OHD) levels are a risk factor for acute respiratory infection (e.g., bronchiolitis) in children. However, little is known about the relation of circulating 25OHD with the many downstream functional molecules in target organs - such as the airway - and with clinical outcomes. In this prospective multicenter study of infants (age <1 year) hospitalized with bronchiolitis, we measured serum 25OHD levels and profiled the metabolome of 144 nasopharyngeal airway samples. Among 254 metabolites identified, we defined a set of 20 metabolites that are related to lower serum 25OHD and higher vitamin D-binding protein levels...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29287405/direct-infusion-mass-spectrometric-identification-of-molecular-species-of-glycerophospholipid-in-three-species-of-edible-whelk-from-yellow-sea
#2
Kai-Qi Gang, Da-Yong Zhou, Ting Lu, Zhong-Yuan Liu, Qi Zhao, Hong-Kai Xie, Liang Song, Fereidoon Shahidi
Whelk has been exploited commercially as a delicacy for a long time. Although previous studies have suggested that whelk might serve as a potential rich source of long chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFA) enriched phospholipid (PL), the molecular species profile of the PL have not been reported yet. In this study, more than 220 molecular species of glycerophospholipid (GP) belonging to eight classes including glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine, lysoglycerophosphoethanolamine, lysoglycerophosphoserine and lysoglycerophosphoinositol in three species of edible whelks (Buccinium yokomaruae, Neptunea arthritica cumingi Cosse and Volutharpa ampullaceal) were identified for the first time by using direct infusion tandem mass spectrometric method...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29215741/analysis-of-sensitive-skin-barrier-function-basic-indicators-and-sebum-composition
#3
Linna Fan, Yan Jia, Le Cui, Xinchao Li, Congfen He
Sensitive skin (SS) is a condition characterised by high reactivity, low tolerance, and susceptibility to allergies of the skin. Owing to changes in the environment and marketing strategies, as well as the increasing public awareness about skin care, attention to skin condition is gradually increasing. To explore the differences in the skin barrier of SS and normal skin (NS), a questionnaire survey was conducted and basic indicators of the skin barrier were analysed. It was found that sebum secretion in the SS group was lower than that in the NS group, suggesting that the development of SS might be associated with sebum secretion and its specific components...
December 7, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29215148/31-p-t2-s-of-phosphomonoesters-phosphodiesters-and-inorganic-phosphate-in-the-human-brain-at-7t
#4
Wybe J M van der Kemp, Dennis W J Klomp, Jannie P Wijnen
PURPOSE: To determine the phosphorus-31 T2 s of phosphomonoesters, phosphodiesters, and inorganic phosphate in the healthy human brain at 7T. METHODS: A 3D chemical shift imaging multi-echo sequence with composite block pulses for refocusing was used to measure one free induction decay (FID) and seven full echoes with an echo spacing of 45 ms on the brain of nine healthy volunteers (age range 22-45 years; average age 27 ± 8 years). Spectral fitting was used to determine the change in metabolic signal amplitude with echo time...
December 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29203059/increased-glutamate%C3%A2-glutamine-levels-in-the-thalamus-of-patients-with-essential-tremor-a-preliminary-proton-mr-spectroscopic-study
#5
Gaetano Barbagallo, Gennarina Arabia, Fabiana Novellino, Rita Nisticò, Maria Salsone, Maurizio Morelli, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The aim of this study was to investigate the thalamic biochemical profile in patients with essential tremor (ET), using proton magnetic resonance spectroscopy (1H-MRS), and to explore the correlations between clinical and biochemical data. METHODS: Sixteen patients with ET and 14 healthy controls participated in this study. After conventional MR imaging, single-voxel 1H-MRS (TR = 2000 ms; TE = 28 ms) was performed by using a PROBE-SV system implemented on a 3-T scanner...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29200821/spectropathology-corroborated-multimodal-quantitative-imaging-biomarkers-for-neuroretinal-degeneration-in-diabetic-retinopathy
#6
Arpan Guha Mazumder, Swarnadip Chatterjee, Saunak Chatterjee, Juan Jose Gonzalez, Swarnendu Bag, Sambuddha Ghosh, Anirban Mukherjee, Jyotirmoy Chatterjee
Introduction: Image-based early detection for diabetic retinopathy (DR) needs value addition due to lack of well-defined disease-specific quantitative imaging biomarkers (QIBs) for neuroretinal degeneration and spectropathological information at the systemic level. Retinal neurodegeneration is an early event in the pathogenesis of DR. Therefore, development of an integrated assessment method for detecting neuroretinal degeneration using spectropathology and QIBs is necessary for the early diagnosis of DR...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29191459/impact-of-real-time-metabolomics-in-liver-transplantation-graft-evaluation-and-donor-recipient-matching
#7
Francois Faitot, Camille Besch, Stephanie Battini, Elisa Ruhland, Mihaela Onea, Pietro Addeo, Marie-Lorraine Woehl-Jaeglé, Bernard Ellero, Philippe Bachellier, Izzie-Jacques Namer
BACKGROUND AND AIMS: The purpose of this study was to evaluate the potential value of high-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS-NMR) metabolomic analysis of back-table biopsies for the prediction of early allograft dysfunction and donor-recipient matching. Indeed there is an emerging need to assess the metabolic state of liver allograft especially in the novel setting of machine perfusion preservation and DCD grafts. HR-MAS-NMR could be a useful tool in this setting as it can extemporaneously provide untargeted metabolic profile...
November 27, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29191088/the-delaying-effect-of-alpha-glycerophosphocholine-on-senescence-transthyretin-deposition-and-osteoarthritis-in-senescence-accelerated-mouse-prone-8-mice
#8
Kiminori Matsubara, Mayumi Okuda, Sachi Shibata, Shigeru Miyaki, Takeshi Ohkubo, Hanae Izu, Tsutomu Fujii
Administration of alpha-glycerophosphocholine (GPC), a choline compound in food, is expected to contribute to human health. In this study, we evaluated its effect on aging in senescence-accelerated mouse prone 8 (SAMP8) mice. Male SAMP8 mice had free access to a commercial stock diet and drinking water with or without GPC (0.07 mg/ml). Mice in the GPC group had significantly lower total senescence grading score than that of the control group at 36 weeks of age. Administration of GPC decreased the deposition of transthyretin (TTR), an amyloidogenic protein, in the brain...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29146344/lipid-profiles-in-different-parts-of-two-species-of-scallops-chlamys-farreri-and-patinopecten-yessoensis
#9
Xiao-Pei Hu, Qing-Da An, Da-Yong Zhou, Ting Lu, Fa-Wen Yin, Liang Song, Qi Zhao, Jiang-Hua Zhang, Lei Qin, Bei-Wei Zhu, Fereidoon Shahidi
Different classes of lipids and phospholipids (PL) as well as fatty acid (FA) compositions, and glycerophospholipid (GP) molecular species in edible parts (adductor muscles) and by-products (gonads and mantles) of scallops Patinopecten yessoensis and Chlamys farreri were characterized. The lipids contained high levels of polyunsaturated FA (PUFA) (20.44-58.81% of total FAs) and PL (54.99-78.26% of total lipids). Among PL, phosphatidylcholine (41.39-51.86 mol%) was dominant. More than 230 GP species belonging to glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine, lysoglycerophosphoethanolamine and lysoglycerophosphoinositol were characterized...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29103689/a-metabolomic-investigation-into-the-effects-of-temperature-on-streptococcus-agalactiae-from-nile-tilapia-oreochromis-niloticus-based-on-uplc-ms-ms
#10
Wen-Ting Hu, Wei-Liang Guo, Ai-Yun Meng, Yun Sun, Shi-Feng Wang, Zhen-Yu Xie, Yong-Can Zhou, Chaozu He
Streptococcosis caused by Streptococcus agalactiae is one of the most serious diseases in farmed tilapia, and temperature is one of the most important environmental factors related to its outbreak. To elucidate the influence of temperature variation on the pathogen from a metabolic perspective, the global metabolomics of 2 pathogenic strains of S. agalactiae from sick tilapia were analyzed at 35°C and 25°C using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) combined with pattern recognition approaches and pathway analysis...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29080862/plasma-metabolites-from-choline-pathway-and-risk-of-cardiovascular-disease-in-the-predimed-prevention-with-mediterranean-diet-study
#11
Marta Guasch-Ferré, Frank B Hu, Miguel Ruiz-Canela, Mònica Bulló, Estefanía Toledo, Dong D Wang, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramon Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Emilio Ros, Courtney Dennis, Liming Liang, Clary B Clish, Miguel A Martínez-González, Jordi Salas-Salvadó
BACKGROUND: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. METHODS AND RESULTS: We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29076604/mass-spectrometry-characterization-of-endophytic-bacterium-curtobacterium-sp-strain-er1-6-isolated-from-citrus-sinensis
#12
Francisca Diana da Silva Araújo, Daiene Souza Santos, Carolina Clepf Pagotto, Welington Luiz de Araújo, Marcos Nogueira Eberlin
The bacteria of the genus Curtobacterium are usually seen as plant pathogen, but some species have been identified as endophytes of different crops, and could as such present a potential for disease control and plant growth promotion. We have therefore applied the desorption electrospray ionization mass spectrometry imaging (DESI-MSI) in the direct analysis of living Curtobacterium sp. strain ER1/6 colonies to map the surface metabolites, and electrospray ionization tandem mass spectrometry (ESI-MS/MS) for characterization of these compounds...
October 27, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29069098/exploration-of-human-brain-tumour-metabolism-using-pairwise-metabolite-metabolite-correlation-analysis-mmca-of-hr-mas-1h-nmr-spectra
#13
Basetti Madhu, Alexandra Jauhiainen, Sean McGuire, John R Griffiths
METHODS: We quantified 378 HRMAS 1H NMR spectra of human brain tumours (132 glioblastomas, 101 astrocytomas, 75 meningiomas, 37 oligodendrogliomas and 33 metastases) from the eTumour database and looked for metabolic interactions by metabolite-metabolite correlation analysis (MMCA). RESULTS: All tumour types showed remarkably similar metabolic correlations. Lactate correlated positively with alanine, glutamate with glutamine; creatine + phosphocreatine (tCr) correlated positively with lactate, alanine and choline + phosphocholine + glycerophosphocholine (tCho), and tCho correlated positively with lactate; fatty acids correlated negatively with lactate, glutamate + glutamine (tGlut), tCr and tCho...
2017: PloS One
https://www.readbyqxmd.com/read/28989676/rapid-determination-of-medulloblastoma-subgroup-affiliation-with-mass-spectrometry-using-a-handheld-picosecond-infrared-laser-desorption-probe
#14
Michael Woolman, Isabelle Ferry, Claudia M Kuzan-Fischer, Megan Wu, Jing Zou, Taira Kiyota, Semra Isik, Delaram Dara, Ahmed Aman, Sunit Das, Michael D Taylor, James T Rutka, Howard J Ginsberg, Arash Zarrine-Afsar
Medulloblastoma (MB), the most prevalent malignant childhood brain tumour, consists of at least 4 distinct subgroups each of which possesses a unique survival rate and response to treatment. To rapidly determine MB subgroup affiliation in a manner that would be actionable during surgery, we subjected murine xenograft tumours of two MB subgroups (SHH and Group 3) to Mass Spectrometry (MS) profiling using a handheld Picosecond InfraRed Laser (PIRL) desorption probe and interface developed by our group. This platform provides real time MS profiles of tissue based on laser desorbed lipids and small molecules with only 5-10 seconds of sampling...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28983683/in-vivo-metabolic-profiles-as-determined-by-31-p-and-short-te-1-h-mr-spectroscopy-no-difference-between-patients-with-idh-wildtype-and-idh-mutant-gliomas
#15
Katharina J Wenger, Elke Hattingen, Kea Franz, Joachim Steinbach, Oliver Bähr, Ulrich Pilatus
PURPOSE: Previous ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas. We investigated whether these changes can be found in vivo using (1)H-decoupled (31)P magnetic resonance spectroscopic imaging (MRSI) with 3D chemical shift imaging (CSI) at 3 T in patients with low and high-grade gliomas. METHODS: The study included 33 prospectively enrolled, mostly untreated patients who met spectral quality criteria according to the World Health Organization (WHO II n = 7, WHO III n = 17, WHO IV n = 9; 25 patients IDHmut, 8 patients IDHwt)...
October 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28958564/characterization-of-lipids-in-three-species-of-sea-urchin
#16
Xin Zhou, Da-Yong Zhou, Ting Lu, Zhong-Yuan Liu, Qi Zhao, Yu-Xin Liu, Xiao-Pei Hu, Jiang-Hua Zhang, Fereidoon Shahidi
Sea urchin gonad has been regarded as a "healthy" food. Although previous studies have suggested that sea urchin gonad might serve as a potential rich source of long chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFA) enriched phospholipid (PL), the molecular species profile of its PL has rarely been reported. In this study, about 200 molecular species of glycerophospholipid (GP), including glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine and lysoglycerophosphoethanolamine, in gonads from three species of sea urchin (Glyptocidaris crenularis, Strongylocentrotus intermedius and Strongylocentrotus nudus) were characterized using tandem mass spectrometry...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28958033/an-objective-short-sleep-insomnia-disorder-subtype-is-associated-with-reduced-brain-metabolite-concentrations-in-vivo-a-preliminary-magnetic-resonance-spectroscopy-assessment
#17
Christopher B Miller, Caroline D Rae, Michael A Green, Brendon J Yee, Christopher J Gordon, Angela L D'Rozario, Simon D Kyle, Colin A Espie, Ronald R Grunstein, Delwyn J Bartlett
Objectives: To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs). Methods: PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water)...
November 1, 2017: Sleep
https://www.readbyqxmd.com/read/28948745/-anti-inflammation-effect-of-jinlingzi-san-in-rat-metabonomics-based-on-1h-nmr-and-lc-ms-technology
#18
Shu-Jie Shen, Su-Fang Shui, Bing-Kun Xiao, Jian-Yun Yang, Rong-Qing Huang
To further explore the regulatory effect of Jinlingzi San on in vivo inflammatory mechanism during inflammatory treatment, this study adopted 1H-NMR and LC-MS technology to analyze differences in in vivo metabolites of carrageen-induce rat foot swelling model. Besides, biomarkers related to inflammation models of Jinlingzi San in SD rats were discovered to speculate the regulatory mechanism of Jinlingzi San in resisting carrageen-induce inflammation. Through the analysis of detection spectrum, we found 18 biomarkers of metabolites(citrate, pyruvate, malic acid, succinate, glutamate, lysine, tartrate, 2-oxobutyric acid, glycine, guanosine, 9-cis-retinoic acid, triphosphate, inosine 5'-diphosphate, inosine diphosphate, tripolyphosphate, inorganic triphosphate, glycerophosphocholine, 21-deoxycortisol)...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28934030/metabolomic-analysis-of-n-acetylcysteine-protection-of-injury-from-gadolinium-dtpa-contrast-agent-in-rats-with-chronic-renal-failure
#19
Chuanling Wan, Rong Xue, Youyang Zhan, Yijie Wu, Xiaojing Li, Fengkui Pei
Gadolinium-based contrast agents (GBCAs) are frequently used to enhance the diagnostic efficacy of magnetic resonance imaging. On the other hand, the association between GBCA administration in patients with advanced renal disease and nephrogenic systemic fibrosis (NSF) was also noted. NSF is a systemic disorder characterized by widespread tissue fibrosis that may lead to death. N-acetylcysteine (NAC) protects rats from injury induced by gadolinium-based contrast agents, but the underlying mechanisms remain unclear...
September 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28927849/metabolome-wide-association-study-of-peripheral-parasitemia-in-plasmodium-vivax-malaria
#20
Luiz Gustavo Gardinassi, Regina Joice Cordy, Marcus V G Lacerda, Jorge L Salinas, Wuelton M Monteiro, Gisely C Melo, André M Siqueira, Fernando F Val, ViLinh Tran, Dean P Jones, Mary R Galinski, Shuzhao Li
BACKGROUND: Plasmodium vivax is one of the leading causes of malaria worldwide. Infections with this parasite cause diverse clinical manifestations, and recent studies revealed that infections with P. vivax can result in severe and fatal disease. Despite these facts, biological traits of the host response and parasite metabolism during P. vivax malaria are still largely underexplored. Parasitemia is clearly related to progression and severity of malaria caused by P. falciparum, however the effects of parasitemia during infections with P...
December 2017: International Journal of Medical Microbiology: IJMM
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