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https://www.readbyqxmd.com/read/29034696/development-of-the-supported-employment-comprehensive-cognitive-enhancement-and-social-skills-program-for-adults-on-the-autism-spectrum-results-of-initial-study
#1
Mary J Baker-Ericzén, Meghan A Fitch, Mikaela Kinnear, Melissa M Jenkins, Elizabeth W Twamley, Linda Smith, Gabriel Montano, Joshua Feder, Pamela J Crooke, Michelle G Winner, Juan Leon
The population of adults on the autism spectrum continues to increase, and vocational outcomes are particularly poor. Longitudinal studies of adults with autism spectrum and without intellectual disability have shown consistent and persistent deficits across cognitive, social, and vocational domains, indicating a need for effective treatments of functional disabilities as each impact employment. This initial pilot study is an open trial investigation of the feasibility, acceptability, and initial estimates of outcomes for the newly developed Supported Employment, Comprehensive Cognitive Enhancement, and Social Skills intervention, a manualized "soft skills" curriculum, to enhance both cognitive and social development in adults with autism spectrum...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29034690/educator-perspectives-on-the-postsecondary-transition-difficulties-of-students-with-autism
#2
Rebecca Elias, Ashley E Muskett, Susan W White
Addressing the challenges of adolescents and emerging adults with autism spectrum disorder is crucial to improving the outcomes of these students in the postsecondary setting. Although secondary and postsecondary educators and staff are critical to helping these students access services, there has been little investigation into the perspectives of this stakeholder group, with respect to the needs of postsecondary students with autism spectrum disorder. A series of focus groups was conducted with secondary and postsecondary educators to understand educator perspectives related to the challenges faced by postsecondary students with autism spectrum disorder...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29034517/medication-use-by-adolescents-and-adults-with-fragile-x-syndrome
#3
D J Laxman, J S Greenberg, L S DaWalt, J Hong, M G Aman, M Mailick
BACKGROUND: The behavioural challenges and medical conditions associated with fragile X syndrome (FXS) can lead to increased need for medications. METHOD: This longitudinal study examined the use of prescription medications for psychotropic and non-psychotropic purposes by adolescents and adults with FXS drawn from a North American community sample (N = 105). Odds and probabilities of continuing or discontinuing medication were calculated. Predictors of medication use were calculated...
October 15, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29027066/white-matter-microstructure-of-the-human-mirror-neuron-system-is-related-to-symptom-severity-in-adults-with-autism
#4
Odette Fründt, Robert Schulz, Daniel Schöttle, Bastian Cheng, Götz Thomalla, Hanna Braaß, Christos Ganos, Nicole David, Ina Peiker, Andreas K Engel, Tobias Bäumer, Alexander Münchau
Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity...
October 12, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29024843/multisensory-integration-and-adhd-like-traits-evidence-for-an-abnormal-temporal-integration-window-in-adhd
#5
Maria Panagiotidi, Paul G Overton, Tom Stafford
Abnormalities in multimodal processing have been found in many developmental disorders such as autism and dyslexia. However, surprisingly little empirical work has been conducted to test the integrity of multisensory integration in Attention Deficit Hyperactivity Disorder (ADHD). The main aim of the present study was to examine links between symptoms of ADHD (as measured using a self-report scale in a healthy adult population) and the temporal aspects of multisensory processing. More specifically, a Simultaneity Judgement (SJ) and a Temporal Order Judgement (TOJ) task were used in participants with low and high levels of ADHD-like traits to measure the temporal integration window and Just-Noticeable Difference (JND) (respectively) between the timing of an auditory beep and a visual pattern presented over a broad range of stimulus onset asynchronies...
October 9, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29023853/antibiotics-gut-microbiome-and-obesity
#6
Karen S W Leong, José G B Derraik, Paul L Hofman, Wayne S Cutfield
Antibiotics have been hailed by many as 'miracle drugs' that have been effectively treating infectious diseases for over a century, leading to a marked reduction in morbidity and mortality. However, with the increasing use of antibiotics, we are now faced not only with the increasing threat of antibiotic resistance, but also with a rising concern about potential long-term effects of antibiotics on human health, including the development of obesity. The obesity pandemic continues to increase, a problem that affects both adults and children alike...
October 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29021936/utilizing-peak-relational-training-system-to-teach-visual-gustatory-and-auditory-relations-to-adults-with-developmental-disabilities
#7
Autumn McKeel, Jaime Matas
Two multiple baseline designs were conducted across participants to determine if the promoting the emergence of advanced knowledge (PEAK) equivalence module was an effective tool in teaching adults with autism relationships between stimuli. More specifically, a transitivity program utilizing the gustatory sensory modality was implemented. Stimuli were selected and probed initially preceding the training. First, gustatory stimuli to a visual picture were trained. Then, a visual picture to a spoken word was trained...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29021934/the-effects-of-bug-in-ear-coaching-on-pre-service-behavior-analysts-use-of-functional-communication-training
#8
Kathleen Artman-Meeker, Nancy Rosenberg, Natalie Badgett, Xueyan Yang, Ashley Penney
Behavior analysts play an important role in supporting the behavior and learning of young children with disabilities in natural settings. However, there is very little research related specifically to developing the skills and competencies needed by pre-service behavior analysts. This study examined the effects of "bug-in-ear" (BIE) coaching on pre-service behavior analysts' implementation of functional communication training with pre-school children with autism in their classrooms. BIE coaching was associated with increases in the rate of functional communication training trials each intern initiated per session and in the fidelity with which interns implemented functional communication training...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29020791/parents-and-young-adults-perspectives-on-transition-outcomes-for-young-adults-with-autism
#9
Collette Sosnowy, Chloe Silverman, Paul Shattuck
Existing research shows that young adults with autism spectrum disorder have poorer outcomes than their peers with other developmental disabilities in the key areas of independent living, postsecondary education, and employment. However, we understand little about how young adults with autism and their families understand and value outcomes and whether these indicators match their goals and aspirations. We interviewed parents (n = 21) and young adults with autism spectrum disorder (n = 20) about their experiences with the transition to adulthood to understand what they consider to be desirable outcomes and how they seek to achieve them...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29020056/differences-in-change-blindness-to-real-life-scenes-in-adults-with-autism-spectrum-conditions
#10
Chris Ashwin, Sally Wheelwright, Simon Baron-Cohen
People often fail to detect large changes to visual scenes following a brief interruption, an effect known as 'change blindness'. People with autism spectrum conditions (ASC) have superior attention to detail and better discrimination of targets, and often notice small details that are missed by others. Together these predict people with autism should show enhanced perception of changes in simple change detection paradigms, including reduced change blindness. However, change blindness studies to date have reported mixed results in ASC, which have sometimes included no differences to controls or even enhanced change blindness...
2017: PloS One
https://www.readbyqxmd.com/read/29019631/disparities-in-life-course-outcomes-for-transition-aged-youth-with-disabilities
#11
Kruti Acharya, Regina Meza, Michael E Msall
Close to 750,000 youth with special health care needs transition to adult health care in the United States every year; however, less than one-half receive transition-planning services. Using the "F-words" organizing framework, this article explores life course outcomes and disparities in transition-aged youth with disabilities, with a special focus on youth with autism, Down syndrome, and cerebral palsy. Despite the importance of transition, a review of the available literature revealed that (1) youth with disabilities continue to have poor outcomes in all six "F-words" domains (ie, function, family, fitness, fun, friends, and future) and (2) transition outcomes vary by race/ethnicity and disability...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28988347/diagnosing-autism-in-adults-with-intellectual-disability-validation-of-the-dibas-r-in-an-independent-sample
#12
Manuel Heinrich, Julia Böhm, Tanja Sappok
The study assessed the diagnostic validity of the diagnostic behavioral assessment for autism spectrum disorders-revised (DiBAS-R; 19-item screening scale based on ratings by caregivers) in a clinical sample of 381 adults with ID. Analysis revealed a sensitivity of 0.82 and a specificity of 0.67 in the overall sample (70.3% agreement). Sensitivity (0.79) and specificity (0.84) were balanced in individuals with mild to moderate ID (83.3% agreement), while specificity was lower in individuals with severe to profound ID (sensitivity: 0...
October 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28987970/an-evaluation-of-the-production-effects-of-video-self-modeling
#13
Roderick D O'Handley, Keith D Allen
A multiple baseline across tasks design was used to evaluate the production effects of video self-modeling on three activities of daily living tasks of an adult male with Autism Spectrum Disorder and Intellectual Disability. Results indicated large increases in task accuracy after the production of a self-modeling video for each task, but before the video was viewed by the participant. Results also indicated small increases when the participant was directed to view the same video self-models before being prompted to complete each task...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28985096/parents-perspectives-of-physical-activity-in-their-adult-children-with-autism-spectrum-disorder-a-social-ecological-approach
#14
Alice M Buchanan, Benjamin Miedema, Georgia C Frey
The purpose of this study was to investigate parent perceptions of the physical activity (PA) engagement of their adult children with autism spectrum disorders. The theoretical framework used in this study was social ecology. Participants were nine parents from families with one adult child with autism spectrum disorder whose ages ranged from 18 to 42. Using phenomenological interviews, which explored parents' life experience and meaning making, four themes were generated: supports and advocacy for PA, engaging in PA independently, benefits of PA, and barriers to or reasons for disengaging in particular activities...
October 6, 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28984854/adult-zebrafish-in-cns-disease-modeling-a-tank-that-s-half-full-not-half-empty-and-still-filling
#15
Darya A Meshalkina, Elana V Kysil, Jason E Warnick, Konstantin A Demin, Allan V Kalueff
The zebrafish (Danio rerio) is increasingly used in a broad array of biomedical studies, from cancer research to drug screening. Zebrafish also represent an emerging model organism for studying complex brain diseases. The number of zebrafish neuroscience studies is exponentially growing, significantly outpacing those conducted with rodents or other model organisms. Yet, there is still a substantial amount of resistance in adopting zebrafish as a first-choice model system. Studies of the repertoire of zebrafish neural and behavioral functions continue to reveal new opportunities for understanding the pathobiology of various CNS deficits...
October 6, 2017: Lab Animal
https://www.readbyqxmd.com/read/28984196/multitype-bellman-harris-branching-model-provides-biological-predictors-of-early-stages-of-adult-hippocampal-neurogenesis
#16
Biao Li, Amanda Sierra, Juan Jose Deudero, Fatih Semerci, Andrew Laitman, Marek Kimmel, Mirjana Maletic-Savatic
BACKGROUND: Adult hippocampal neurogenesis, the process of formation of new neurons, occurs throughout life in the hippocampus. New neurons have been associated with learning and memory as well as mood control, and impaired neurogenesis has been linked to depression, schizophrenia, autism and cognitive decline during aging. Thus, understanding the biological properties of adult neurogenesis has important implications for human health. Computational models of neurogenesis have attempted to derive biologically relevant knowledge, hard to achieve using experimentation...
October 3, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28983326/inter-trial-coherence-of-medial-frontal-theta-oscillations-linked-to-differential-feedback-processing-in-youth-and-young-adults-with-autism
#17
Stefon van Noordt, Jia Wu, Archana Venkataraman, Michael J Larson, Mikle South, Michael J Crowley
BACKGROUND: Impairment in prediction and appreciation for choice outcomes could contribute to several core symptoms of ASD. We examined electroencephalography (EEG) oscillations in 27 youth and young adults diagnosed with autism spectrum disorder (ASD) and 22 IQ-matched neurotypical controls while they performed a chance-based reward prediction task. METHOD: We re-analyzed our previously published ERP data (Larson et al., 2011) and examined theta band oscillations (4-8 Hz) at frontal midline sites, within a timing window that overlaps with the feedback-related negativity (FRN)...
May 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/28980172/brief-report-inter-relationship-between-emotion-regulation-intolerance-of-uncertainty-anxiety-and-depression-in-youth-with-autism-spectrum-disorder
#18
Ru Ying Cai, Amanda L Richdale, Cheryl Dissanayake, Mirko Uljarević
The aim of this study was to examine the inter-relationship between emotion regulation (ER), intolerance of uncertainty (IU), and symptoms of anxiety and depression in adolescents and young adults diagnosed with autism spectrum disorder (ASD). Sixty-one individuals aged 14-24 years (M age = 18.19; SD age = 2.19) completed the ER Questionnaire, IU Scale-12, Diagnostic and Statistical Manual of Mental Disorders-5 Dimensional Anxiety Scales, Patient Health Questionnaire-9, and Autism-Spectrum Quotient-Short...
October 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28980099/prevalence-of-schizophrenia-spectrum-disorders-in-average-iq-adults-with-autism-spectrum-disorders-a-meta-analysis
#19
Jorge Lugo Marín, Montserrat Alviani Rodríguez-Franco, Vinita Mahtani Chugani, María Magán Maganto, Emiliano Díez Villoria, Ricardo Canal Bedia
Since their separation as independent diagnostics, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) have been conceptualized as mutually exclusive disorders. Similarities between both disorders can lead to misdiagnosis, especially when it comes to average-IQ adults who were not identified during childhood. The aim of this review was to examine the occurrence of SSD in average-IQ adults with ASD. Electronic and manual searches identified a total of 278 references, of which 10 were included in a meta-analysis...
October 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28974727/timing-and-localization-of-human-dystrophin-isoform-expression-provide-insights-into-the-cognitive-phenotype-of-duchenne-muscular-dystrophy
#20
Nathalie Doorenweerd, Ahmed Mahfouz, Maaike van Putten, Rajaram Kaliyaperumal, Peter A C T' Hoen, Jos G M Hendriksen, Annemieke M Aartsma-Rus, Jan J G M Verschuuren, Erik H Niks, Marcel J T Reinders, Hermien E Kan, Boudewijn P F Lelieveldt
Duchenne muscular dystrophy (DMD) is a muscular dystrophy with high incidence of learning and behavioural problems and is associated with neurodevelopmental disorders. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across human brain development, using unique transcriptomic data from Allen Human Brain and BrainSpan atlases. Dystrophin isoforms show large changes in expression through life with pronounced differences between the foetal and adult human brain...
October 3, 2017: Scientific Reports
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