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Pemphigus

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https://www.readbyqxmd.com/read/29146127/rituximab-as-first-line-adjuvant-in-pemphigus-retrospective-analysis-of-the-long-term-outcomes-in-a-single-center
#1
Keshavamurthy Vinay, Simone Cazzaniga, Kyle T Amber, Laurence Feldmeyer, Luigi Naldi, Luca Borradori
No abstract text is available yet for this article.
November 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29145342/evaluation-of-anti-desmoglein-1-and-anti-desmoglein-3-autoantibody-titers-in-pemphigus-patients-at-the-time-of-the-initial-diagnosis-and-after-clinical-remission
#2
Irene Russo, Francesco Paolo De Siena, Andrea Saponeri, Mauro Alaibac
It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and clinical activity of pemphigus.The aim of our study was to evaluate if clinical remission of pemphigus relates to the presence of anti-desmoglein autoantibodies.Thirty patients with pemphigus vulgaris and 7 patients with pemphigus foliaceous were included in the study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132851/association-between-pemphigus-and-psoriasis-a-population-based-large-scale-study
#3
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29132070/sixteen-year-history-of-rituximab-therapy-for-1085-pemphigus-vulgaris-patients-a-systematic-review
#4
REVIEW
Soheil Tavakolpour, HamidReza Mahmoudi, Kamran Balighi, Robabeh Abedini, Maryam Daneshpazhooh
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Search in PubMed results in 114 relevant studies, which met the criteria...
November 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29131038/bullous-diseases
#5
Caroline Corbaux, Pascal Joly
Autoimmune bullous diseases are a heterogeneous group of blistering diseases affecting the skin and/or mucous membrane. Systemic corticosteroids, which are often associated with immunosuppressants, are the main treatment option for these diseases. The 2 main biologics used in the treatment of autoimmune bullous diseases are rituximab, especially in pemphigus and mucous membrane pemphigoid, and omalizumab in bullous pemphigoid. Rituximab is a promising therapeutic option in pemphigus and mucous membrane pemphigoid...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29130480/antidesmoglein-1-and-3-antibodies-in-healthy-subjects-of-a-population-in-the-peruvian-high-amazon
#6
Willy Ramos, Jesús Díaz, Ericson L Gutierrez, Jose S Lazarte, Mary C Bohnett, Gerardo Ronceros, Alex G Ortega-Loayza
BACKGROUND: The objective of this study was to determine the presence of anti-Dsg1 and Dsg3 antibodies in healthy subjects of the high Peruvian Amazon (Tuemal, Rodriguez de Mendoza province, department of Amazonas) to establish the theoretical presence of environmental factors or triggers in the area. MATERIALS AND METHODS: Cross-sectional study. The study population included persons of any age or gender, clinically healthy, who were evaluated by a dermatologist to confirm the absence of blistering diseases...
November 11, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29111983/acute-flare-of-bullous-pemphigus-with-pembrolizumab-used-for-treatment-of-metastatic-urothelial-cancer
#7
Rohan Garje, Justin J Chau, Jina Chung, Karolyn Wanat, Yousef Zakharia
In the past decade, the resurgence of immunotherapy has changed the landscape of cancer therapy. Checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen-4, programmed death-1 on lymphocytes, and programmed death ligand-1 on tumors cells are currently utilized in the management of several cancers. These agents are double-edged sword with the positive effect being robust antitumor response but on the other side they can throttle up the normal immunologic homeostasis in a negative way, leading to adverse autoimmune toxicities...
November 3, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29110080/pemphigus-trigger-factors-special-focus-on-pemphigus-vulgaris-and-pemphigus-foliaceus
#8
REVIEW
Soheil Tavakolpour
Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed...
November 6, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29108872/corrigendum-to-the-possible-role-of-interleukin-35-and-its-therapeutic-potential-in-pemphigus-int-immunol-42-2017-11-17
#9
Soheil Tavakolpour, Forough Kheiry, Hajar SadatMirsafaei, Meisam Akhlaghdoust
No abstract text is available yet for this article.
November 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29108425/bipolar-disorder-associated-with-another-autoimmune-disease-pemphigus-a-population-based-study
#10
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
OBJECTIVES: Recent evidence suggests a notable role for inflammation and immune dysregulation in the neuroprogression of bipolar disorders (BD). Several autoimmune comorbidities have been reported in association with BD. However, the epidemiological relationship between pemphigus and BD has not yet been elucidated. We aimed to estimate the association between pemphigus and BD using a large-scale, real-life computerized database. METHODS: Data for this study were retrieved from the database of the Clalit Health Services, the largest, state-mandated, health service organization in Israel...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29107213/current-and-future-treatment-options-for-pemphigus-is-it-time-to-move-towards-more-effective-treatments
#11
REVIEW
Soheil Tavakolpour
Systemic administration of corticosteroid (CS) remains the standard gold treatment for pemphigus. However, because of several long-term adverse effects, steroid-sparing agents are usually prescribed in combination with CSs. Despite the high number of available studies, the choice of best drugs to treat pemphigus remains controversial. Therapeutic approaches for pemphigus can be divided into traditional treatment and emerging ones. Personalized medicine, which aims to increase the efficacy as well as reduce adverse effects of treatments, could be considered as the future option...
December 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29105150/feasibility-study-for-clinical-application-of-caspase-3-inhibitors-in-pemphigus-vulgaris
#12
W V J Hariton, A Galichet, T Vanden Berghe, A M Overmiller, M G Mahoney, W Declercq, E J Müller
No abstract text is available yet for this article.
November 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29096849/successful-and-well-tolerated-bi-weekly-immunoadsorption-regimen-in-pemphigus-vulgaris
#13
Jenny Dietze, Bernd Hohenstein, Sergey Tselmin, Ulrich Julius, Stefan R Bornstein, Stefan Beissert, Claudia Günther
BACKGROUND: Pemphigus vulgaris is a chronic autoimmune disease characterized by blisters and erosions forming in the mucous membranes and the skin. Many patients are severely impaired by pain, weight loss and increased risk of infections. The disease is mediated by specific autoantibodies directed against desmogleins that contribute to connect keratinocytes in the epidermis. Autoantibody deposition in the skin causes inflammation and intraepidermal akantholysis. The concentration of autoantibodies in serum correlates with disease activity...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29095065/anterior-scleritis-associated-with-pemphigus-vulgaris
#14
Tal Zeeli, Efrat Bar-Ilan, Zohar Habot-Wilner, Eli Sprecher
We present a rare co-occurrence of anterior scleritis developing in a patient with recalcitrant pemphigus vulgaris. We discuss the clinical and therapeutic implications of these two conditions and offer concise recommendations.
November 2, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29071023/the-effect-of-low-level-laser-therapy-on-pemphigus-vulgaris-lesions-a-pilot-study
#15
Maryam Yousef, Parvin Mansouri, Masoud Partovikia, Mitra Esmaili, Shima Younespour, Ladan Hassani
Introduction: Pemphigus vulgaris is a chronic blistering skin disease. Management of recalcitrant pemphigus ulcers is a great problem. Low Level Laser Therapy (LLLT) is known to supply direct biostimulative light energy to body cells. This study evaluates the efficacy of low power laser in the healing of pemphigus lesions. Methods: Ten patients with pemphigus vulgaris were enrolled in the trial. The LED-LLLT system used was the Thor LED clusters (109, 69 or 19 diode) (England) with 660 nm wavelength in continuous wave (CW) and 30 mW energy...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29067729/antioxidant-status-of-serum-bilirubin-uric-acid-and-albumin-in-pemphigus-vulgaris
#16
W C Li, L J Mo, X Shi, Z Y Lin, Y Y Li, Z Yang, C L Wu, X H Li, Y Z Luo, L Q Qin, W N Mo
BACKGROUND: Oxidative stress and low antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Pemphigus vulgaris (PV) is an extremely severe autoimmune bullous dermatosis characterized by intraepithelial bullae on the skin and mucosa, and its antioxidant status is not fully understood. AIM: To assess correlations between PV and serum antioxidant levels of bilirubin, uric acid (UA) and albumin. METHODS: We enrolled 116 patients newly diagnosed with PV who were admitted to the First Affiliated Hospital of Guangxi Medical University (Guangxi, China), and 108 healthy controls (HCs)...
October 25, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29066741/peripheral-cd19-hi-b-cells-exhibit-activated-phenotype-and-functionality-in-promoting-igg-and-igm-production-in-human-autoimmune-diseases
#17
Zhicui Liu, Weihong Zeng, Xiangyang Huang, Shujun Wang, Jie Zheng, Meng Pan, Ying Wang
Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19(hi) B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. CD19(hi) B cells could be induced in vitro after co-culturing fully activated CD4(+) T cells with autologous B cells...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29064314/rituximab-in-pemphigus
#18
Vivien Hebert, Pascal Joly
Pemphigus is a severe autoimmune blistering disease mediated by pathogenic anti-desmoglein antibodies leading to an inter keratinocyte disjunction. Rituximab is a monoclonal antibody that binds to the CD-20 antigen of B lymphocytes, which causes B-cell depletion and a subsequent reduction in pathogenic autoantibodies. Its therapeutic role in pemphigus has been progressively growing with increasing evidence of successful outcomes. Rituximab was initially off-labeled used as an alternative in patients with recalcitrant or relapsing pemphigus and in patients with contraindications to systemic corticosteroids...
October 24, 2017: Immunotherapy
https://www.readbyqxmd.com/read/29055412/desmoglein-3-reactive-b-cells-hiding-in-pemphigus-lesions
#19
Hayato Takahashi
Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Thus, it seems likely that autoreactive B cells reside and produce autoantibodies in these tissues. Yuan et al. analyzed lymphocytes in the lesional skin of patients with pemphigus vulgaris using several experimental techniques and concluded that desmoglein 3-reactive B cells were present...
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#20
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
October 18, 2017: Journal of Internal Medicine
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