keyword
MENU ▼
Read by QxMD icon Read
search

Pemphigus

keyword
https://www.readbyqxmd.com/read/29333762/pemphigus-herpetiformis-with-autoantibodies-to-desmocollins-1-2-and-3
#1
Y E Tay, S S J Lee, Y L Lim
No abstract text is available yet for this article.
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29327699/nail-changes-in-autoimmune-blistering-disorders-a-case-control-study
#2
Vaishnavi Gopal, Manjunath Mala Shenoy, Vishal Bejai, Thansiha Nargis
BACKGROUND: Pemphigus and pemphigoid disorders produce blistering cutaneous lesions. Earlier case reports state that nail involvement is uncommon in these autoimmune blistering disorders. AIMS AND OBJECTIVES: To study nail changes in autoimmune blistering disorders. METHODS: A case-control study was conducted where 40 cases and 40 controls were evaluated for nail changes. RESULTS: Nail changes were seen in 72.5% of cases and 17...
January 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29314211/a-rare-presentation-of-congenital-syphilis-pemphigus-syphiliticus-in-a-newborn-infant-with-extensive-desquamation-of-the-extremities
#3
Elizabeth A Wang, Cindy J Chambers, Marc Silverstein
Congenital syphilis is an infection transmitted from mother to fetus and can present with early but variable cutaneous manifestations. In rare situations, a bullous eruption known as pemphigus syphiliticus may develop. We present an unusual case of broad desquamation of the extremities in a newborn infant who was found to have congenital syphilis. Pemphigus syphiliticus should be considered in the differential diagnosis of neonatal bullous eruptions and erosions.
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29313939/location-of-oral-lesions-predicts-treatment-resistance-in-pemphigus-vulgaris
#4
H Yuan, M Pan
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29313220/pemphigus-a-comprehensive-review-on-pathogenesis-clinical-presentation-and-novel-therapeutic-approaches
#5
REVIEW
Robert Pollmann, Thomas Schmidt, Rüdiger Eming, Michael Hertl
Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced by IgG autoantibodies against components of desmosomes. Specifically, IgG against the desmosomal adhesion proteins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), preferentially target their ectodomains which are presumably critical for the transinteraction and signalling function of these adhesion molecules...
January 8, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29307589/pathogenic-igg4-autoantibodies-from-endemic-pemphigus-foliaceus-recognize-a-desmoglein-1-conformational-epitope
#6
Flor Evangelista, Aleeza J Roth, Phillip Prisayanh, Brenda R Temple, Ning Li, Ye Qian, Donna A Culton, Zhi Liu, Oliver J Harrison, Julia Brasch, Barry Honig, Lawrence Shapiro, Luis A Diaz
Fogo Selvagem (FS), the endemic form of pemphigus foliaceus, is mediated by pathogenic IgG4 autoantibodies against the amino-terminal extracellular cadherin domain of the desmosomal cadherin desmoglein 1 (Dsg1). Here we define the detailed epitopes of these pathogenic antibodies. Proteolytic footprinting showed that IgG4 from 95% of FS donor sera (19/20) recognized a 16-residue peptide (A129LNSMGQDLERPLELR144) from the EC1 domain of Dsg1 that overlaps the binding site for an adhesive-partner desmosomal cadherin molecule...
January 4, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29307572/langerhans-cells-prevent-autoimmunity-via-expansion-of-keratinocyte-antigen-specific-regulatory-t-cells
#7
Daniela Y Kitashima, Tetsuro Kobayashi, Therese Woodring, Kacey Idouchi, Thomas Doebel, Benjamin Voisin, Takeya Adachi, Takeshi Ouchi, Hayato Takahashi, Koji Nishifuji, Daniel H Kaplan, Björn E Clausen, Masayuki Amagai, Keisuke Nagao
Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering disease pemphigus. Although antibody-mediated disease mechanisms in pemphigus are extensively characterized, the T cell aspect of this autoimmune disease still remains poorly understood. Herein, we utilized a mouse model of CD4+ T cell-mediated autoimmunity against Dsg3 to show that acquisition of Dsg3 and subsequent presentation to T cells by LCs depended on the C-type lectin langerin...
December 20, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29299590/rituximab-as-single-long-term-maintenance-therapy-in-patients-with-difficult-to-treat-pemphigus
#8
Julia Sanchez, Saskia Ingen-Housz-Oro, Olivier Chosidow, Frank Antonicelli, Philippe Bernard
No abstract text is available yet for this article.
January 3, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29299431/a-review-on-botanicals-with-wound-healing-activity-for-pemphigus-vulgaris-perspective-of-traditional-persian-medicine-and-conventional-medicine
#9
REVIEW
Fatemeh Atarzadeh, Amir Mohammad Jaladat, Babak Daneshfard, Ladan Dastgheib, Mohammad Kamalinejad, Gholamreza Amin
Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings. Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29297927/an-oral-disease-severity-score-odss-validated-for-use-in-oral-pemphigus-vulgaris
#10
M Ormond, H McParland, A N A Donaldson, M Andiappan, R J Cook, M Escudier, E Hullah, J Higham, R McMillan, J Taylor, P J Shirlaw, S J Challacombe, J F Setterfield
OBJECTIVES: The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in pemphigus vulgaris (PV). A secondary aim was to compare the inter - intra- observer variability and ease of use with the Physician's Global Assessment (PGA) and the oral scoring methods used in Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI). METHODS: 15 patients with mild to moderately severe oral PV were scored for disease severity by 10 oral medicine clinicians using the ODSS, PGA and the oral sections of ABSIS and PDAI...
January 3, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29289266/is-myc-an-important-biomarker-myc-expression-in-immune-disorders-and-cancer
#11
REVIEW
Shivtia Trop-Steinberg, Yehudit Azar
The proto-oncogene Myc serves as a paradigm for understanding the dynamics of transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer development and neoplastic transformation. We review recent research regarding functions of Myc as an important modulator in immune disorders, postallogeneic hematopoietic stem cell transplantation (HSCT) and several cancers. Myc overexpression has been repeatedly linked to immune disorders and specific cancers, such as myasthenia gravis, psoriasis, pemphigus vulgaris, atherosclerosis, long-term allogeneic survival among HSCT patients, (primary) inflammatory breast cancer, (primary) ovarian carcinoma and hematological malignancies: acute myeloid leukemia, chronic myelogenous leukemia, Hodgkin's lymphoma and diffuse large B-cell lymphoma...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29282189/cutaneous-mucormycosis-a-fatal-complication-of-immunosuppressant-therapy-for-pemphigus-vulgaris
#12
Kanika Sahni, Dipankar De, Sunil Dogra, Amrinderjit Kanwar, Uma Nahar Saikia
A 62-year-old man with no comorbidities presented to the outpatient department of our Institute with a history of extensive vesiculobullous and erosive skin lesions and oral erosions for 2 months and fever for 1 week. A diagnosis of pemphigus vulgaris was made based on histopathology and direct immunofluorescence of a skin biopsy specimen, and the patient was started on oral prednisolone 40 mg per day along with intravenous antibiotics (amoxicillin-clavulanic acid, gentamicin, and metronidazole) empirically, pending blood and skin swab culture and sensitivity reports...
2017: Skinmed
https://www.readbyqxmd.com/read/29278440/a-novel-lateral-flow-immunoassay-for-the-rapid-detection-of-anti-dsg3-igg-serum-autoantibodies-in-pemphigus-vulgaris
#13
Thomas Schmidt, Susanne Mauracher, Lena Bender, Brandon Greene, Jonas Kurzhals, Rüdiger Eming, Ralf Dostatni, Michael Hertl
Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation of a novel lateral flow immunoassay (LFIA) which rapidly detects anti-desmoglein 3 (Dsg3) IgG in human serum. In contrast to other diagnostic procedures, the assay is compact and simple to perform and delivers a fast "yes" or "no" answer within 10 min without additional hardware requirements for test evaluation...
December 26, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29277685/cardiac-rhythm-and-pacemaking-abnormalities-in-patients-affected-by-endemic-pemphigus-in-colombia-may-be-a-result-of-deposition-of-autoantibodies-complement-fibrinogen-and-other-molecules
#14
Ana Maria Abreu Velez, Michael S Howard, Jorge Enrique Velazquez-Velez
BACKGROUND: We showed that one third of the patients affected by endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF) display autoreactivity to the heart. OBJECTIVE: We aim to investigate rhythm disturbances with presence of autoantibodies and correlate them with electrocardiographic changes in these patients. METHODS: We performed a study comparing 30 patients and 30 controls from the endemic area, matched by demographics including age, sex and weight; work activities, comorbidities, among other variables...
December 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29275386/chickenpox-an-ageless-disease
#15
Annalan Mathew Dwight Navaratnam, Nan Ma, Maria Farrukh, Aza Abdulla
A 97-year-old woman presented with 4-day history of vesicular rash, initially at the feet but then spread up to the thighs bilaterally, abdomen and trunk. The initial differentials included bullous pemphigus and cellulitis by the emergency department. She was then managed as bullous pemphigus by the acute medical team and started on high-dose steroids, with no other differentials considered. When her care was taken over by the general medical team, varicella zoster virus (VZV) infection was suspected. After confirmation by the dermatology team regarding the clinical diagnosis and the positive VZV DNA swabs, she was started on acyclovir...
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29255476/mpo-anca-associated-vasculitis-with-mononeuritis-multiplex-following-influenza-vaccination
#16
Stefanie Eindhoven, Jolien Levels, Margriet Huisman, Koos Ruizeveld de Winter, Virgil Dalm, Rehmat Alwani
Background: Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Case report: We describe the case of a 67-year old man who presented with a myeloperoxidase-ANCA associated vasculitis with renal involvement and mononeuritis multiplex after seasonal influenza vaccination...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29252172/the-value-of-the-biochip-mosaic-based-indirect-immunofluorescence-technique-in-the-diagnosis-of-pemphigus-and-bullous-pemphigoid-in-turkish-patients
#17
Birgül Özkesici, Derya Mutlu, Levent Dönmez, Soner Uzun
Autoimmune bullous diseases (ABD) are a rarely seen group of diseases, of which pemphigus and bullous pemphigoid (BP) are the major groups. Diagnosis is generally based on the combination of clinical features, histopathologic and immunofluorescence (IF) findings, and/or enzyme-linked immunosorbent assay (ELISA). Aims of the work were to determine the value of the innovative BIOCHIP mosaic-based indirect IF technique in the diagnosis of pemphigus and BP in Turkish patients. A total of 63 patients (45 pemphigus and 18 BP) in the active phase of the disease alongside 35 healthy controls were included in the study...
October 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29252171/spectrum-of-autoimmune-bullous-diseases-in-northern-greece-a-4-year-retrospective-study-and-review-of-the-literature
#18
Aikaterini Patsatsi, Foteini Lamprou, Miltiadis Kokolios, Despoina Stylianidou, Anastasia Trigoni, Dimitrios Kalampalikis, Dimitrios Sotiriadis
Bullous Diseases Unit at the 2nd Department of Dermatology and Venereology, Aristotle University of Thessaloniki was founded with the aim to provide the optimal diagnostic approach and treatment of patients with autoimmune bullous diseases (AΙBD). We processed all AIBD files of patients diagnosed from 2011 to 2014 in order to record all epidemiological data and therapeutic manipulations during monitoring. 57 patients were diagnosed with intraepidermal and 62 with subepidermal bullous diseases. There were 51 cases (89%) of pemphigus vulgaris (PV) and 6 (11%) of pemphigus foliaceus (PF), whereas 45 (73%) patients were diagnosed with bullous pemphigoid (BP), 9 (14%) with mucous membrane pemphigoid (MMP), 3 (5%) with pemphigoid gestationis (PG), 3 (5%) with linear IgA dermatosis (LAD), 1 (2%) with epidermolysis bullosa aquisita (EBA), and 1 patient with an undefined subepidermal AIBD...
October 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29252170/hla-e-0101-0103x-is-associated-with-susceptibility-to-pemphigus-vulgaris-a-case-control-study
#19
Ece Altun A, Savas Yayli A, Bayram Toraman, Deniz Aksu Arica, Ersan Kalay, Leyla Baykal Selcuk, Sevgi Bahadir
Pemphigus vulgaris (PV) is a life-threatening, autoimmune blistering disease of the skin and mucous membranes. The relationship between PV and human leukocyte antigen (HLA) has been studied in several reports. Previous reports have demonstrated that HLA-E polymorphisms may have a role in the susceptibility to various autoimmune diseases. Our aim was to evaluate the role of HLA-E gene polymorphisms in the pathogenesis of PV in a Turkish population. A total of 49 patients with PV and 50 healthy subjects were enrolled into the study...
October 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29252169/epidemiology-of-pemphigus-in-turkey-one-year-prospective-study-of-220-cases
#20
Savas Yayli, Mehmet Harman, Emel Bulbul Baskan, Ayse Akman Karakas, Yeser Genc, Bengu Gerceker Turk, Evren Odyakmaz Demirsoy, Suhan Gunasti, Serap Gunes Bilgili, Nilsel Ilter, Ayten Ferahbas, Ekin Savk, Fatma Sule Afsar, Sema Aytekin, Tamer Irfan Kaya, Sibel Berksoy Hayta, Zuleyha Ozgen, Mehmet Salih Gurel, Ercan Caliskan, Didem Didar Balci, Sule Gungor, Yelda Kapicioglu, Pinar Ozuguz, Sebnem Aktan, Asena Dogramaci, Ibrahim Kokcam, Nahide Onsun, Deniz Seckin, Murat Durdu, Recep Dursun, Munise Daye, Nursel Dilek, Ercan Karabacak, Asli Bilgic Temel, Cengizhan Erdem, Ece Altun, Dilek Gungor, Demet Kartal, Melih Akyol, Esra Koku Koku Aksu, Soner Uzun
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey...
October 2017: Acta Dermatovenerologica Croatica: ADC
keyword
keyword
626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"