Liping Wang, Shanru Yi, Xinyu Cui, Zhenxiang Guo, Mengting Wang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang, Shaorong Gao, Guang Yang, Jiayu Chen, Rui Gao
Embryos, originating from fertilized eggs, undergo continuous cell division and differentiation, accompanied by dramatic changes in transcription, translation, and metabolism. Chromatin regulators, including transcription factors (TFs), play indispensable roles in regulating these processes. Recently, the trophoblast regulator TFAP2C was identified as crucial in initiating early cell fate decisions. However, Tfap2c transcripts persist in both the inner cell mass and trophectoderm of blastocysts, prompting inquiry into Tfap2c's function in post-lineage establishment...
April 20, 2024: Cell Reports