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https://www.readbyqxmd.com/read/29779174/correction-to-impaired-bioenergetics-in-mutant-mitochondrial-dna-determines-cell-fate-during-seizure-like-activity
#1
Stjepana Kovac, Elisavet Preza, Henry Houlden, Matthew C Walker, Andrey Y Abramov
The original version of this article unfortunately contained mistake. The author's family name "Kov ac" was written with space thus this should be corrected to "Kovac".
May 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29778981/walking-the-line-the-fate-of-nanomaterials-at-biological-barriers
#2
REVIEW
Huan Meng, Wei Leong, Kam W Leong, Chunying Chen, Yuliang Zhao
Biological systems have developed an efficient multi-tiered defense system to block foreign substances such as engineered nanomaterials (NMs) from causing damage. In a pathological scenario, the disease itself may also pose additional barriers due to the imbalance between abnormal cells and their surrounding microenvironment, and NMs could behave similarly or differently to classic foreign substances, depending on their unique characteristics. Thus, understanding the mechanisms that govern the fate of NMs against these biological barriers, including the strategies that can be used to shift their fate between access and blockage, become key information for NMs design...
May 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/29778888/rapid-phenotyping-of-cancer-stem-cells-using-multichannel-nanosensor-arrays
#3
Yingying Geng, Hira L Goel, Ngoc B Le, Tatsuyuki Yoshii, Rubul Mout, Gulen Y Tonga, John J Amante, Arthur M Mercurio, Vincent M Rotello
Cancer stem cells (CSCs) contribute to multidrug resistance, tumor recurrence and metastasis, making them prime therapeutic targets. Their ability to differentiate and lose stem cell properties makes them challenging to study. Currently, there is no simple assay that can capture and trace the dynamic phenotypic changes on the CSC surface. Here, we report rapid discrimination of breast CSCs from non-CSCs using a nanoparticle-fluorescent-protein based sensor. This nanosensor was employed to discriminate CSCs from non-CSCs, as well CSCs that had differentiated in vitro in two breast cancer models...
May 17, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29778818/the-fate-of-the-tricuspid-valve-following-the-transatrial-closure-of-the-ventricular-septal-defect
#4
Raffaele Giordano, Massimiliano Cantinotti, Luigi Di Tommaso, Giuseppe Comentale, Andrea Tozzi, Emanuele Pilato, Gabriele Iannelli, Gaetano Palma
BACKGROUND: The transatrial repair of the ventricular septal defect (VSD) requires an adequate exposure of its rim. We retrospectively evaluated the impact of adopting the tricuspid valve incision (TVI) technique, either with detachment or radial incision, on the postoperative outcome of children undergoing surgical VSD repair. METHODS: From January 2008 to September 2017 we retrospectively enrolled 141 patients, divided into two groups: 97 patients were subjected to TVI (68...
May 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29778594/differetial-toxin-profiles-of-ciguatoxins-in-marine-organisms-chemistry-fate-and-global-distribution
#5
REVIEW
Lucía Soliño, Pedro Reis Costa
Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affects up to 500,000 people annually due to fish consumption...
May 17, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29778178/release-kinetics-of-vanadium-from-vanadium-iii-iv-and-v-oxides-effect-of-ph-temperature-and-oxide-dose
#6
Xingyun Hu, Yuyan Yue, Xianjia Peng
Batch experiments were performed to derive the rate laws for the proton-promoted dissolution of the main vanadium (III, IV and V) oxides at pH 3.1-10.0. The release rates of vanadium are closely related to the aqueous pH, and several obvious differences were observed in the release behavior of vanadium from the dissolution of V2 O5 and vanadium(III, IV) oxides. In the first 2hr, the release rates of vanadium from V2 O3 were r=1.14·([H+ ])0.269 at pH 3.0-6.0 and r=0.016·([H+ ])-0.048 at pH 6.0-10.0; the release rates from VO2 were r=0...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778155/effect-of-phosphate-releasing-in-activated-sludge-on-phosphorus-removal-from-municipal-wastewater
#7
Jie Ge, Xiaoguang Meng, Yonghui Song, Amalia Terracciano
Aluminum and ferric salts are commonly used in municipal wastewater treatment plants (WWPTs) for phosphorus (P) removal. In this study, on-site jar tests were conducted to determine the removal of different P species from the fresh samples in the presence and absence of activated sludge (AS) with different doses of alum, poly-aluminum chloride, and ferric chloride at different pH. The soluble P (SP) concentration in the samples was about 0.63mg/L. When the mixed liquor containing AS was treated with 8mg/L of Al, SP could be reduced to 0...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778016/multiscale-reconstruction-of-a-synthetic-biomimetic-micro-niche-for-enhancing-and-monitoring-the-differentiation-of-stem-cells
#8
Rui Li, Jinming Li, Jianbin Xu, Dexter Siu Hong Wong, Xiaoyu Chen, Weihao Yuan, Liming Bian
Stem cells reside in a three-dimensional (3D) niche microenvironment, which provides specific cues, including cell-matrix interactions and soluble factors, that are essential to the differentiation of stem cells in vivo. Herein we demonstrate a general approach to the synthetic reconstruction of 3D biomimetic niche environment of stem cells by the multiscale combination of macroscopic porous hydrogels and a nanoscale upconversion nanoparticles (UCNP)-based nanocomplex. The porous biopolymeric hydrogels emulate the spongy bone microstructure and provide 3D environment conducive to the differentiation of seeded stem cells...
May 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29777963/red-wolf-canis-rufus-sperm-quality-and-quantity-is-affected-by-semen-collection-method-extender-components-and-post-thaw-holding-temperature
#9
Ashley D Franklin, William T Waddell, Karen L Goodrowe
Cryopreserving genetic resources is becoming increasingly important for species management. In the zoo-based red wolf (Canis rufus) population, inbreeding continues to increase in the absence of new founders. Through banking sperm, we preserve genetic diversity and create the ability to decrease inbreeding accumulation in the future. The quality and quantity of banked sperm can be affected by cryopreservation media and semen collection methods. This study's objectives were to further optimize semen extender used for red wolf sperm cryopreservation, investigate effects of post-thaw holding temperature, and to determine if urethral catheterization is an effective method for semen collection in this species...
May 16, 2018: Theriogenology
https://www.readbyqxmd.com/read/29777574/factors-influencing-the-umbilical-cord-blood-stem-cell-industry-an-evolving-treatment-landscape
#10
REVIEW
Carla Dessels, Marco Alessandrini, Michael Sean Pepper
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29777229/fate-of-the-metabolically-healthy-obese-is-this-term-a-misnomer-a-study-from-the-clinical-practice-research-datalink
#11
Osama Moussa, Chanpreet Arhi, Paul Ziprin, Ara Darzi, Omar Khan, Sanjay Purkayastha
INTRODUCTION: The metabolically healthy obese (MHO) phenotype may express typical characteristics on long-term follow-up. Little is known about the initiation of this phenotypes and its future stability. AIM: The Clinical Practice Research Datalink (CPRD) is a large-scale primary care database. The aim of this study was to assess the stability of, and evaluate the factors associated with a transition into an unhealthy outcome in, a MHO population in the UK. METHODS: The CPRD was interrogated for a diagnosis of 'obesity' and cross-referenced with a body mass index (BMI) ≥35 kg/m2 ; participants were further classified as MH using a clinical diagnostic code or a relative therapeutic code...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29777051/cd36-initiates-the-secretory-phenotype-during-the-establishment-of-cellular-senescence
#12
Mengyang Chong, Tao Yin, Rui Chen, Handan Xiang, Lifeng Yuan, Yi Ding, Christopher C Pan, Zhen Tang, Peter B Alexander, Yinjun Jia, Qi-Jing Li, Xiao-Fan Wang
Cellular senescence is a unique cell fate characterized by stable proliferative arrest and the extensive production and secretion of various inflammatory proteins, a phenomenon known as the senescence-associated secretory phenotype (SASP). The molecular mechanisms responsible for generating a SASP in response to senescent stimuli remain largely obscure. Here, using unbiased gene expression profiling, we discover that the scavenger receptor CD36 is rapidly upregulated in multiple cell types in response to replicative, oncogenic, and chemical senescent stimuli...
May 18, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29775939/biodegradation-in-seawater-of-pah-and-alkylphenols-from-produced-water-of-a-north-sea-platform
#13
Synnøve Lofthus, Inger K Almås, Peter Evans, Oliver Pelz, Odd Gunnar Brakstad
Operational planned discharges of produced water (PW) to the marine environment from offshore oil production installations, contain low concentrations of dispersed oil compounds, like polycyclic aromatic hydrocarbons (PAHs) and alkylated phenols (APs). Biotransformation in natural seawater (SW) of naphthalenes/PAHs and phenol/APs in field-collected PW from a North Sea platform was investigated in this biodegradation study. The PW was diluted in SW from a Norwegian fjord, and the biodegradation study was performed in slowly rotating carousels at 13 °C over a period of 62 days...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29775821/vermiremediation-of-metal-loid-s-via-eichornia-crassipes-phytomass-extraction-a-sustainable-technique-for-plant-amelioration
#14
Arnab Majumdar, Anil Barla, Munish Kumar Upadhyay, Dibyarpita Ghosh, Punarbasu Chaudhuri, Sudhakar Srivastava, Sutapa Bose
Eichhornia crassipes (water hyacinth), imparts deficiency of soluble arsenic and other toxic metal (loid)s through rhizofiltration and phytoaccumulation. Without proper management strategy, this phytoremediation of metal (loid)s might fail and get reverted back to the environment, contaminating the nearby water bodies. This study, focused on bio-conversion of phytoremediating hyacinths, spiked with 100 times and greater arsenic, lead and cadmium concentrations than the average water contamination, ranging in 58...
May 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29775646/the-rna-binding-protein-ars2-supports-hematopoiesis-at-multiple-levels
#15
Seerat Elahi, Shawn M Egan, G Aaron Holling, Rachel L Kandefer, Michael J Nemeth, Scott H Olejniczak
Recent biochemical characterization of Arsenic resistance protein 2 (Ars2) has established it as central to determining the fate of nascent RNA polymerase II (RNAPII) transcripts. Through interactions with the nuclear 5'-7-methylguanosine (7mG) cap binding complex (CBC), Ars2 promotes co-transcriptional processing coupled with nuclear export or degradation of several classes of RNAPII transcripts, allowing for gene expression programs that facilitate rapid and sustained proliferation of immortalized cells in culture...
May 15, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29775615/extracellular-matrix-protein-dmp1-suppresses-osteogenic-differentiation-of-mesenchymal-stem-cells
#16
Shufan Zhang, Huixuan Wan, Peng Wang, Mengmeng Liu, Gongchen Li, Chunxue Zhang, Yao Sun
Mesenchymal Stem Cells (MSCs) are self-renewing and multipotent stem cells which was investigated for diverse clinical applications. However, complex mechanism of MSCs fate determination is still not fully disclosed. Extracellular matrix (ECM) proteins contribute to maintain MSCs stemness by providing extracellular microenvironment. Increasing evidences show that ECM proteins could also regulate the fate of MSCs directly. Dentin matrix protein 1 (DMP1) is an ECM protein enrich in bone tissue and terminal cells, which well-known in promoting osteoblasts and osteocytes maturation, and facilitate mineralization...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775422/fate-of-four-phthalate-plasticizers-under-various-wastewater-treatment-processes
#17
Dana L Armstrong, Clifford P Rice, Mark Ramirez, Alba Torrents
The fate of four phthalate plasticizers during wastewater treatment processes at six different wastewater treatment plants (WWTPs) was investigated. Concentrations of benzyl butyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP), and diisodecyl phthalate (DiDP) were determined prior to either aerobic or anaerobic (conventional and advanced) treatment, after treatment, and in final, dewatered solids. Despite their elevated use worldwide, the fate of DiNP and DiDP during wastewater treatment have not been well characterized...
May 18, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29775245/subunits-of-the-dna-polymerase-alpha-primase-complex-promote-notch-mediated-proliferation-with-discrete-and-shared-functions-in-c-elegans-germline
#18
Dong Suk Yoon, Dong Seok Cha, Mohammad A Alfhili, Brett D Keiper, Myon-Hee Lee
Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays a critical role at several junctures in animal development. In C. elegans, GLP-1/Notch signaling is essential for both germline stem cell maintenance and germ cell proliferation during gonad development. Here, we show that subunits (POLA-1, DIV-1, PRI-1, and PRI-2) of the DNA polymerase alpha-primase complex are required for germ cell proliferation in response to GLP-1/Notch signaling in different tissues at different developmental stages...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29775100/phytoremediation-of-btex-and-naphthalene-from-produced-water-spill-sites-using-poaceae
#19
Amanda Rose Shores, Brittany Hethcock, Melinda Laituri
Surface spills of water produced from hydraulic fracturing can expose soil and groundwater to organics such as BTEX and naphthalene (BTEX&N) as well as high concentrations of salt. As an alternative to soil excavation, we evaluated the effectiveness of BTEX&N soil remediation using 2 grasses present in Colorado. Perennial ryegrass and foxtail barley were grown separately in pots in the greenhouse and exposed to salt or a synthesized produced-water slurry containing relevant levels of salt and BTEX&N...
July 3, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29774393/developmental-origin-of-the-cardiac-conduction-system-insight-from-lineage-tracing
#20
Rajiv A Mohan, Bastiaan J Boukens, Vincent M Christoffels
The components of the cardiac conduction system (CCS) generate and propagate the electrical impulse that initiates cardiac contraction. These interconnected components share properties, such as automaticity, that set them apart from the working myocardium of the atria and ventricles. A variety of tools and approaches have been used to define the CCS lineages. These include genetic labeling of cells expressing lineage markers and fate mapping of dye labeled cells, which we will discuss in this review. We conclude that there is not a single CCS lineage, but instead early cell fate decisions segregate the lineages of the CCS components while they remain interconnected...
May 17, 2018: Pediatric Cardiology
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