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Tobias Baumann, Matthias Exner, Nediljko Budisa
To date, the two systems most extensively used for noncanonical amino acid (ncAA) incorporation via orthogonal translation are based on the Methanococcus jannaschii TyrRS/tRNA CUA(Tyr) and the Methanosarcina barkeri/Methanosarcina mazei PylRS/tRNA CUA(Pyl) pairs. Here, we summarize the development and usage of the pyrrolysine-based system for orthogonal translation, a process that allows for the recombinant production of site-specifically labeled proteins and peptides. Via stop codon suppression in Escherichia coli and mammalian cells, genetically encoded biomolecules can be equipped with a great diversity of chemical functionalities including click chemistry handles, post-translational modifications, and photocaged sidechains...
October 26, 2016: Advances in Biochemical Engineering/biotechnology
Seunghyun Hwang, Youngjun Choi
Collegiate student athletes face psychological stressors in adjusting to campus life. This study used preexisting, nationally representative data administered by the National Collegiate Athletic Association for student athletes in 2010 to explore the conjunctive relationships among demographics, personal characteristics, social contexts, and physical condition in predicting perceived stress. The number of valid samples was 19,967 from 609 member institutions. A data mining methodology (i.e., SEARCH) was applied to model the distribution of the perceived stress...
December 2016: Psychological Reports
Caleb M Adler, Melissa P DelBello, Wade Weber, Miranda Williams, Luis Rodrigo Patino Duran, David Fleck, Erin Boespflug, James Eliassen, Stephen M Strakowski, Jon Divine
OBJECTIVE: To examine effects of participating in collegiate football on neural health several years after retirement. We hypothesized that relative cortical thinning and loss of white matter integrity would be observed in former players. DESIGN: Former NCAA Division I football players were compared with demographically similar track-and-field athletes with regard to cortical thickness and white matter integrity. SETTING: Participants participated in MRI scans at the Center for Imaging Research at the University of Cincinnati...
October 17, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Eric C McCarty, Matthew J Kraeutler, Paula Langner, Shane Cook, Byron Ellis, Jenna M Godfrey
We conducted a study to identify and contrast patterns in the treatment of common injuries that occur in National Football League (NFL) players and National Collegiate Athletic Association (NCAA) Division I football players. Orthopedic team physicians for all 32 NFL and 119 NCAA Division I football teams were asked to complete a survey regarding demographics and preferred treatment of a variety of injuries encountered in football players. Responses were received from 31 (97%) of the 32 NFL and 111 (93%) of the 119 NCAA team physicians...
September 2016: American Journal of Orthopedics
D Fulstone, A Chandran, M Barron, L DiPietro
We extend previous analyses and examined sex-differences in the rate and severity of knee injuries among collegiate soccer players between 2004 and 2009. Data from the National Collegiate Athletic Association Injury Surveillance System (NCAA ISS) were used to calculate injury incidence density (ID) per 1 000 athletic exposures (AE). Multivariable regression modeling then tested the relation between sex and knee injury incidence and severity among all injured soccer players, while controlling for contact, setting, and division level, as well as for the interactions among these variables...
October 5, 2016: International Journal of Sports Medicine
Sara L Arena, Kelsey McLaughlin, Anh-Dung Nguyen, James M Smoliga, Kevin R Ford
Athletic individuals may differ in body segment inertial parameter (BSIP) estimates due to differences in body composition, and this may influence calculation of joint kinetics. The purposes of this study were to 1) compare BSIPs predicted by the method introduced by de Leva(1) with DXA-derived BSIPs in collegiate female soccer players, and 2) examine the effects of these BSIPs estimation methods on joint moment and power calculations during a drop vertical jump (DVJ). Twenty female NCAA Division 1 soccer players were recruited...
October 5, 2016: Journal of Applied Biomechanics
John R Harry, Leland A Barker, John A Mercer, Janet S Dufek
There is a wealth of research on impact force characteristics when landing from a jump. However, there are no data on impact forces during landing from a jump with an airborne rotation about the vertical axis. We examined impact force parameters in the vertical and horizontal axes during vertical jump (VJ) landings and vertical jump landings with a 180-degree rotation (VJR). Twenty-four Division 1 male soccer players performed three VJ and VJR landings on a dual-force platform system. Paired-samples t-tests (α=0...
September 22, 2016: Journal of Strength and Conditioning Research
Kristof Kipp, Philip J Malloy, Jordan Smith, Matthew D Giordanelli, Michael T Kiely, Christopher F Geiser, Timothy J Suchomel
The purpose of this study was to investigate the joint- and load-dependent changes in the mechanical demands of the lower extremity joints during the hang power clean (HPC) and the jump shrug (JS). Fifteen male lacrosse players were recruited from an NCAA DI team, and completed three sets of the HPC and JS at 30%, 50%, and 70% of their HPC 1-Repetition Maximum (1-RM HPC) in a counterbalanced and randomized order. Motion analysis and force plate technology were used to calculate the positive work, propulsive phase duration, and peak concentric power at the hip, knee, and ankle joints...
September 16, 2016: Journal of Strength and Conditioning Research
Alexis A Wright, Steven L Dischiavi, James M Smoliga, Jeffrey B Taylor, Eric J Hegedus
OBJECTIVES: To determine if the Lower Quarter Y-Balance Test (LQYBT) is predictive of lower extremity injury in NCAA Division 1 athletes. DESIGN: Prospective cohort, therapy. PARTICIPANTS: One hundred eighty-nine NCAA Division 1 athletes participated in the study and underwent a preparticipation screen that included the LQYBT. Maximal reach distances were recorded in each direction and normalized to leg length. A composite score was calculated by summing the three normalized reach distances and dividing by three times leg length...
June 25, 2016: Physiotherapy
Zachary Y Kerr, Janet E Simon, Dustin R Grooms, Karen G Roos, Randy P Cohen, Thomas P Dompier
BACKGROUND: Research has found that injury rates in football are higher in competition than during practice. However, there is little research on the association between injury rates and type of football practices and how these specific rates compare with those in competitions. PURPOSE: This study utilized data from the National Collegiate Athletic Association Injury Surveillance System (NCAA ISS) to describe men's collegiate football practice injuries (academic years 2004-2005 to 2008-2009) in 4 event types: competitions, scrimmages, regular practices, and walkthroughs...
September 2016: Orthopaedic Journal of Sports Medicine
Anja Kuthning, Patrick Durkin, Stefan Oehm, Michael G Hoesl, Nediljko Budisa, Roderich D Süssmuth
Genetic code engineering that enables reassignment of genetic codons to non-canonical amino acids (ncAAs) is a powerful strategy for enhancing ribosomally synthesized peptides and proteins with functions not commonly found in Nature. Here we report the expression of a ribosomally synthesized and post-translationally modified peptide (RiPP), the 32-mer lantibiotic lichenicidin with a canonical tryptophan (Trp) residue replaced by the ncAA L-β-(thieno[3,2-b]pyrrolyl)alanine ([3,2]Tpa) which does not sustain cell growth in the culture...
2016: Scientific Reports
Megan N Houston, Johanna M Hoch, Bonnie L Van Lunen, Matthew C Hoch
CONTEXT: Health-related quality of life (HRQOL) is a broad term for the impact of injury or illness on physical, psychological, and social health dimensions. Injury has been associated with decreased HRQOL in athletes. However, the influence of injury history, participation status, time since last injury, and injury severity on HRQOL remains unclear. OBJECTIVE: To compare HRQOL in collegiate athletes based on injury history, participation status, time since last injury, and injury severity and to examine relationships between HRQOL outcomes...
August 24, 2016: Journal of Sport Rehabilitation
Gary B Wilkerson, Kevin A Simpson, Ryan A Clark
CONTEXT: Neurocognitive reaction time has been associated with musculoskeletal injury risk, but visuomotor reaction time (VMRT) derived from tests that present greater challenges to visual stimulus detection and motor response execution may have a stronger association. OBJECTIVE: The purposes of this study were to assess VMRT as a predictor of injury and the extent to which improvement may result from VMRT training. DESIGN: Cohort study. SETTING: University athletic performance center...
August 24, 2016: Journal of Sport Rehabilitation
Ryan S McCann, Kyle B Kosik, Masafumi Terada, Megan Q Beard, Gretchen E Buskirk, Phillip A Gribble
CONTEXT: The Star Excursion Balance Test (SEBT) and Functional Movement Screen (FMS) are functional performance measures capable of predicting lower extremity injury risk. While suboptimal SEBT and FMS performances are influenced by multiple factors, the contribution of hip strength and flexibility to these tests is mostly unknown. Examination of hip strength and flexibility influences on the SEBT and FMS may direct clinicians to better methods of correcting functional deficits. OBJECTIVE: Determine the relationships of isometric hip strength and hip passive range of motion (PROM) with functional performance measures...
August 24, 2016: Journal of Sport Rehabilitation
Kelley E C Massengale, Alice Ma, Kelly L Rulison, Jeffrey J Milroy, David L Wyrick
OBJECTIVE: To describe first-year college student-athletes' friendship contexts and test whether their perceptions of alcohol use and approval by different types of friends are associated with their own alcohol use. PARTICIPANTS: First-year student-athletes (N = 2,622) from 47 colleges and universities participating in National Collegiate Athletic Association (NCAA) sports during February-March 2013. METHODS: Student-athletes completed online surveys during the baseline assessment of an alcohol and other drug prevention program evaluation...
September 9, 2016: Journal of American College Health: J of ACH
J L Ayers, M DeBeliso, T G Sevene, K J Adams
Olympic weightlifting movements and their variations are believed to be among the most effective ways to improve power, strength, and speed in athletes. This study investigated the effects of two Olympic weightlifting variations (hang cleans and hang snatches), on power (vertical jump height), strength (1RM back squat), and speed (40-yard sprint) in female collegiate athletes. 23 NCAA Division I female athletes were randomly assigned to either a hang clean group or hang snatch group. Athletes participated in two workout sessions a week for six weeks, performing either hang cleans or hang snatches for five sets of three repetitions with a load of 80-85% 1RM, concurrent with their existing, season-specific, resistance training program...
September 2016: Biology of Sport
Andre Maranhao, Andrew D Ellington
There have been considerable advancements in the incorporation of non-canonical amino acids (ncAA) into proteins over the last two decades. The most widely used method for site-specific incorporation of non-canonical amino acids, amber stop codon suppression, typically employs an orthogonal translation system (OTS) consisting of a heterologous aminoacyl-tRNA synthetase:tRNA pair that can potentially expand an organism's genetic code. However, the orthogonal machinery sometimes imposes fitness costs on an organism, in part due to mischarging and a lack of specificity...
September 7, 2016: ACS Synthetic Biology
Sarah S Gascon, Jessica K Washington, Jence A Rhoads, Keith R Lohse, Gretchen D Oliver
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Karen G Roos, Zachary Y Kerr, Timothy C Mauntel, Aristarque Djoko, Thomas P Dompier, Erik A Wickstrom
BACKGROUND: Ankle sprains are a common injury in collegiate sports. Few studies have examined the epidemiology of individual ligament injuries, specifically the lateral ligament complex (LLC) of the ankle. PURPOSE: To describe the epidemiology, including the estimated yearly national incidence, of LLC sprains among National Collegiate Athletic Association (NCAA) athletes. STUDY DESIGN: Descriptive epidemiology study. METHODS: Injury surveillance data for 25 sports from the NCAA Injury Surveillance Program (NCAA-ISP) for the academic years 2009-2010 to 2014-2015 were used for analysis...
August 29, 2016: American Journal of Sports Medicine
Gérard Grelpois, Charles Sabbagh, Cyril Cosse, Brice Robert, Emilie Chapuis-Roux, Alexandre Ntouba, Thierry Lion, Jean-Marc Regimbeau
BACKGROUND: Day case surgery (DCS) for uncomplicated acute appendicitis (NCAA) is under evaluation. The objective of this prospective, single-center, descriptive, non-randomized, intention-to-treat (ITT) cohort study was to assess the feasibility of DCS for NCAA with a critical analysis of the reasons for exclusion and treatment failures and a focus on patients discharged to home and admitted for DCS on the following day. STUDY DESIGN: From April 2013 to December 2015, NCAA patients meeting the inclusion criteria were included in the study...
August 17, 2016: Journal of the American College of Surgeons
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