Xinnan Liu, Weiqi Zhang, Yichao Han, Hao Cheng, Qi Liu, Shouyu Ke, Fangming Zhu, Ying Lu, Xin Dai, Chuan Wang, Gonghua Huang, Bing Su, Qiang Zou, Huabing Li, Wenyi Zhao, Lianbo Xiao, Linrong Lu, Xuemei Tong, Fan Pan, Hecheng Li, Bin Li
Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke an anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 and STAT1 are interferon-induced genes that play a positive role in the progression of tumors. Here, we showed that IFITM3-deficient Tregs blunted tumor growth by strengthening the tumor-killing response and displayed the Th1-like Treg phenotype with higher secretion of IFNγ. Mechanistically, depletion of IFITM3 enhances the translation and phosphorylation of STAT1...
January 2, 2024: Nature Communications