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IFITM3

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https://www.readbyqxmd.com/read/29904383/influenza-a-virus-facilitates-its-infectivity-by-activating-p53-to-inhibit-the-expression-of-interferon-induced-transmembrane-proteins
#1
Bei Wang, Tze Hau Lam, Mun Kuen Soh, Zhiyong Ye, Jinmiao Chen, Ee Chee Ren
Human influenza virus (IAV) are among the most common pathogens to cause human respiratory infections. A better understanding on interplay between IAV and host factors may provide clues for disease prevention and control. While many viruses are known to downregulate p53 upon entering the cell to reduce the innate host antiviral response, IAV infection is unusual in that it activates p53. However, it has not been clear whether this process has proviral or antiviral effects. In this study, using human isogenic p53 wild-type and p53null A549 cells generated from the CRISPR/Cas9 technology, we observed that p53null cells exhibit significantly reduced viral propagation when infected with influenza A virus (strain A/Puerto Rico/8/1934 H1N1)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29868492/high-level-antibody-response-to-pandemic-influenza-h1n1-09-virus-is-associated-with-interferon-induced-transmembrane-protein-3-rs12252-cc-in-young-adults
#2
Ling Qin, Dayan Wang, Dongfu Li, Yan Zhao, Yanchun Peng, Dannielle Wellington, Yanchao Dai, Huanqin Sun, Jinping Sun, Guihai Liu, Andrew McMichael, Tao Dong, Yonghong Zhang
Background: The C allele of the interferon-induced transmembrane protein-3 ( IFITM3 ) SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%), severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody responses to previous seasonal influenza infections. Cohort and Method: A total 99 young healthy volunteers (18-20 years) were recruited and received an influenza seasonal Vaccination [A/Switzerland/9715293/2013(H3N2), A/California/7/2009 (pdm09H1N1) and B/Jeep/3073/2013-like virus (Flu-B)]...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29709037/correction-histone-demethylase-lsd1-restricts-influenza-a-virus-infection-by-erasing-ifitm3-k88-monomethylation
#3
Jiaoyu Shan, Binbin Zhao, Zhao Shan, Jia Nie, Rong Deng, Rui Xiong, Andy Tsun, Weiqi Pan, Hanzhi Zhao, Ling Chen, Ying Jin, Zhikang Qian, Kawing Lui, Rui Liang, Dan Li, Bing Sun, Dimitri Lavillette, Ke Xu, Bin Li
[This corrects the article DOI: 10.1371/journal.ppat.1006773.].
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29575903/selective-enrichment-and-direct-analysis-of-protein-s-palmitoylation-sites
#4
Emmanuelle Thinon, Joseph P Fernandez, Henrik Molina, Howard C Hang
S-Fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryotes and is important in mammalian physiology and human diseases. While chemical labeling methods have improved the detection and enrichment of S-fatty-acylated proteins, mapping sites of modification and characterizing the endogenously attached fatty acids are still challenging...
May 4, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29575524/distribution-of-ifitm3-polymorphism-dbsnp-rs12252-in-mestizo-populations-in-four-states-of-mexico
#5
J J López-Jiménez, D I Peña-Iñiguez, A L Fletes-Rayas, S E Flores-Martínez, J Sánchez-Corona, R C Rosales-Gomez, H Montoya-Fuentes
Interferon-inducible transmembrane protein 3 (IFITM3) participates in the defense against viral infections. This study identified and compared the frequency of the IFITM3 rs12252 polymorphism in 410 individuals in western Mexico. The western Mexican allelic frequencies (frequency of the "C" allele = 0.18) differ from some American, East Asian and European populations.
March 25, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29528446/characterization-of-migratory-primordial-germ-cells-in-the-aorta-gonad-mesonephros-of-a-4-5-week-old-human-embryo-a-toolbox-to-evaluate-in-vitro-early-gametogenesis
#6
Maria Gomes Fernandes, Monika Bialecka, Daniela C F Salvatori, Susana M Chuva de Sousa Lopes
STUDY QUESTION: Which set of antibodies can be used to identify migratory and early post-migratory human primordial germ cells (hPGCs)? STUDY FINDING: We validated the specificity of 33 antibodies for 31 markers, including POU5F1, NANOG, PRDM1 and TFAP2C as specific markers of hPGCs at 4.5 weeks of development of Carnegie stage (CS12-13), whereas KIT and SOX17 also marked the intra-aortic hematopoietic stem cell cluster in the aorta-gonad-mesonephros (AGM). WHAT IS KNOWN ALREADY: The dynamics of gene expression during germ cell development in mice is well characterized and this knowledge has proved crucial to allow the development of protocols for the in-vitro derivation of functional gametes...
March 8, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29503647/the-host-restriction-factor-interferon-inducible-transmembrane-protein-3-inhibits-vaccinia-virus-infection
#7
Chang Li, Shouwen Du, Mingyao Tian, Yuhang Wang, Jieying Bai, Peng Tan, Wei Liu, Ronglan Yin, Maopeng Wang, Ying Jiang, Yi Li, Na Zhu, Yilong Zhu, Tiyuan Li, Shipin Wu, Ningyi Jin, Fuchu He
Interferons (IFNs) establish dynamic host defense mechanisms by inducing various IFN-stimulated genes that encodes many antiviral innate immune effectors. IFN-inducible transmembrane (IFITM) proteins have been identified as intrinsic antiviral effectors, which block the entry of a broad spectrum of enveloped RNA viruses by interrupting virus-endosomal fusion. However, antiviral activity of IFITM proteins against mammalian DNA virus has not been demonstrated till date. Here, we sought to investigate the antiviral activities and mechanisms of interferon-inducible transmembrane protein 3 (IFITM3) protein against poxvirus infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29356071/the-anti-inflammatory-ifitm-genes-ameliorate-colitis-and-partially-protect-from-tumorigenesis-by-changing-immunity-and-microbiota
#8
Zoya Alteber, Adi Sharbi-Yunger, Meirav Pevsner-Fischer, Dan Blat, Lior Roitman, Esther Tzehoval, Eran Elinav, Lea Eisenbach
Inflammation plays pivotal roles in different stages of tumor development. Screening for predisposing genetic abnormalities and understanding the roles these genes play in the crosstalk between immune and cancer cells will provide new targets for cancer therapy and prevention. The interferon inducible transmembrane (IFITM) genes are involved in pathogenesis of the gastro-intestinal tract. We aimed at delineating the role of IFITM3 in colonic epithelial homeostasis, inflammation and colitis-associated tumorigenesis using IFITM3-deficient mice...
March 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29306950/immune-consequences-of-in-vitro-infection-of-human-peripheral-blood-leukocytes-with-vesicular-stomatitis-virus
#9
Tomasz Tomczyk, Grażyna Wróbel, Radosław Chaber, Iwona Siemieniec, Egbert Piasecki, Małgorzata Krzystek-Korpacka, Beata U Orzechowska
BACKGROUND: Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. Our study aimed to assess the overall immunological consequences of ex vivo infection of PBLs with VSV. METHODS: Phenotypic analysis of lymphocyte subsets and apoptosis were evaluated with flow cytometry. Caspase 3/7 activity was detected by luminescence assay...
2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29281729/histone-demethylase-lsd1-restricts-influenza-a-virus-infection-by-erasing-ifitm3-k88-monomethylation
#10
Jiaoyu Shan, Binbin Zhao, Zhao Shan, Jia Nie, Rong Deng, Rui Xiong, Andy Tsun, Weiqi Pan, Hanzhi Zhao, Ling Chen, Ying Jin, Zhikang Qian, Kawing Lui, Rui Liang, Dan Li, Bing Sun, Dimitri Lavillette, Ke Xu, Bin Li
The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. Inhibition of LSD1 was found to block viral genome transcription and lytic replication of DNA viruses. However, RNA virus genomes do not rely on chromatin structure and histone association, and the role of demethylase activity of LSD1 in RNA virus infections is not anticipated. Here, we identify that, contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29259856/the-expression-profile-of-ifitm-family-gene-in-rats
#11
Yanqin Lu, Qingli Zuo, Yao Zhang, Yanzhou Wang, Tianyou Li, Jinxiang Han
The interferon-inducible transmembrane proteins (IFITMs) are a family of small transmembrane proteins belonging to the interferon (IFN)-stimulated gene (ISG) superfamily and strongly induced by IFNs. In this paper, we studied the expression profile of IFITMs in 32 organ tissues. The IFITM mRNA expression profile showed that IFITM1, IFITM2 and IFITM3 were expressed in each tissue, especially, in spermatophore, spermaduct, testicle and epididymis. The expression of IFITM1, IFITM2 and IFITM3 showed a trend from high to low...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29202190/lack-of-truncated-ifitm3-transcripts-in-cells-homozygous-for-the-rs12252-c-variant-that-is-associated-with-severe-influenza-infection
#12
Shokouh Makvandi-Nejad, Henry Laurenson-Schafer, LiLi Wang, Dannielle Wellington, Yan Zhao, Boquan Jin, Ling Qin, Kerry Kite, Hooman K Moghadam, Chaojun Song, Kevin Clark, Philip Hublitz, Alain R Townsend, Hao Wu, Andrew J McMichael, YongHong Zhang, Tao Dong
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes...
January 4, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29162141/more-than-meets-the-i-the-diverse-antiviral-and-cellular-functions-of-interferon-induced-transmembrane-proteins
#13
REVIEW
Guoli Shi, Olivier Schwartz, Alex A Compton
The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells. This cell-autonomous arsenal consists of nucleic acid sensors and antiviral effectors strategically placed by evolution to detect and restrict invading viruses. While some factors are present at baseline to allow for constant surveillance of the cell interior, others are upregulated by cytokines (such as interferons) that signal a viral infection underway in neighboring cells...
November 21, 2017: Retrovirology
https://www.readbyqxmd.com/read/29132684/interactions-between-lactobacilli-and-chicken-macrophages-induce-antiviral-responses-against-avian-influenza-virus
#14
Bahram Shojadoost, Raveendra R Kulkarni, Jennifer T Brisbin, Wanderley Quinteiro-Filho, Tamiru N Alkie, Shayan Sharif
Macrophages are an important cell type of the innate immune system that upon activation, can exert antiviral functions and also can induce virus-specific adaptive immune responses. Macrophage interaction with certain probiotic bacteria such as lactobacilli can enhance antiviral functions of these cells. We have previously shown that administration of lactobacilli to chickens can effectively augment immune response to vaccine antigens. Here, we investigated the effects of representative strains of three Lactobacillus species, L...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29121968/association-of-ifitm3-rs12252-polymorphisms-bmi-diabetes-and-hypercholesterolemia-with-mild-flu-in-an-iranian-population
#15
Parvaneh Mehrbod, Sana Eybpoosh, Fatemeh Fotouhi, Hadiseh Shokouhi Targhi, Vahideh Mazaheri, Behrokh Farahmand
BACKGROUND: IFITM3 has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individuals to infection. The aim of this study was to investigate the association of rs12252 C polymorphism, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population. METHODS: We conducted a case-control study, including 79 mild flu and 125 flu-negative individuals attending primary care centers of three provinces of Iran (i...
November 9, 2017: Virology Journal
https://www.readbyqxmd.com/read/29079573/the-palmitoyltransferase-zdhhc20-enhances-interferon-induced-transmembrane-protein-3-ifitm3-palmitoylation-and-antiviral-activity
#16
Temet M McMichael, Lizhi Zhang, Mahesh Chemudupati, Jocelyn C Hach, Adam D Kenney, Howard C Hang, Jacob S Yount
Interferon-induced transmembrane protein 3 (IFITM3) is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections. IFITM3 is activated by palmitoylation, a lipid posttranslational modification. Palmitoylation of proteins is primarily mediated by zinc finger DHHC domain-containing palmitoyltransferases (ZDHHCs), but which members of this enzyme family can modify IFITM3 is not known. Here, we screened a library of human cell lines individually lacking ZDHHCs 1-24 and found that IFITM3 palmitoylation and its inhibition of influenza virus infection remained strong in the absence of any single ZDHHC, suggesting functional redundancy of these enzymes in the IFITM3-mediated antiviral response...
December 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29078734/ovarian-cancer-stem-cells-unraveling-a-germline-connection
#17
Seema C Parte, Andrei Smolenkov, Surinder K Batra, Mariusz Z Ratajczak, Sham S Kakar
Ovarian cancer is most lethal among gynecological cancers with often fatal consequences due to lack of effective biomarkers and relapse, which propels ovarian cancer research into unique directions to establish solid targeted therapeutics. "Ovarian stem cells" expressing germline pluripotent markers serve as novel paradigm with potential to address infertility, menopause, and probably influence tumor initiation. Cancer stem cells (CSCs) pose vital role in tumor recurrence and hence it is extremely important to study them with respect to ovarian stem cells across various cancer stages and normal ovaries...
December 15, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29053189/pilot-screening-study-of-targeted-genetic-polymorphisms-for-association-with-seasonal-influenza-hospital-admission
#18
Tonia C Carter, Scott J Hebbring, Jixia Liu, Jonathan D Mosley, Christian M Shaffer, Lynn C Ivacic, Sarah Kopitzke, Elisha L Stefanski, Rob Strenn, Maria E Sundaram, Jennifer Meece, Murray H Brilliant, Jill M Ferdinands, Edward A Belongia
Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune response genes were evaluated for association with seasonal influenza hospitalization in an adult study population with European ancestry. SNP allele and genotype frequencies were compared between hospitalized influenza patients (cases) and population controls in a case-control study that included a discovery group (26 cases and 993 controls) and two independent, validation groups (1 with 84 cases and 4076 controls; the other with 128 cases and 9187 controls)...
March 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/28957419/interference-with-the-production-of-infectious-viral-particles-and-bimodal-inhibition-of-replication-are-broadly-conserved-antiviral-properties-of-ifitms
#19
Kevin Tartour, Xuan-Nhi Nguyen, Romain Appourchaux, Sonia Assil, Véronique Barateau, Louis-Marie Bloyet, Julien Burlaud Gaillard, Marie-Pierre Confort, Beatriz Escudero-Perez, Henri Gruffat, Saw See Hong, Marie Moroso, Olivier Reynard, Stéphanie Reynard, Elodie Decembre, Najate Ftaich, Axel Rossi, Nannan Wu, Frédérick Arnaud, Sylvain Baize, Marlène Dreux, Denis Gerlier, Glaucia Paranhos-Baccala, Viktor Volchkov, Philippe Roingeard, Andrea Cimarelli
IFITMs are broad antiviral factors that block incoming virions in endosomal vesicles, protecting target cells from infection. In the case of HIV-1, we and others reported the existence of an additional antiviral mechanism through which IFITMs lead to the production of virions of reduced infectivity. However, whether this second mechanism of inhibition is unique to HIV or extends to other viruses is currently unknown. To address this question, we have analyzed the susceptibility of a broad spectrum of viruses to the negative imprinting of the virion particles infectivity by IFITMs...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28857475/overexpression-of-ifitm3-predicts-poor-prognosis-in-stage-iia-esophageal-squamous-cell-carcinoma-after-ivor-lewis-esophagectomy
#20
Yang Jia, Zhaohua Xiao, Wenpeng Jiang, Gang Chen, Zhou Wang
BACKGROUND: Recent research has shown that IFITM3 plays an important role in the tumorigenesis of many malignancies. We investigated the clinicopathological variables and prognostic value of IFITM3 in stage IIA esophageal squamous cell carcinoma (ESCC) patients. METHODS: Immunohistochemistry and Western blot analysis were used to examine IFITM3 expression in tumor specimens. The relationships between IFITM3 expression and clinicopathological variables, as well as the five-year survival and recurrence status of patients, were analyzed...
November 2017: Thoracic Cancer
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