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https://www.readbyqxmd.com/read/29785877/hepatitis-b-virus-lymphotropism-emerging-details-and-challenges
#1
Shivali S Joshi, Carla S Coffin
The hepatitis B virus (HBV) is predominantly a hepatotropic virus but also infects cells of the lymphatic system. HBV genomes (DNA, messenger (m)RNA, covalently closed circular (ccc) DNA) and proteins have been found in extrahepatic sites such as peripheral blood mononuclear cells (PBMC), lymph nodes, spleen, bone marrow and cerebrospinal fluid. HBV entry into hepatocytes occurs by binding of the HBV preS1 surface protein to its specific receptor, the bile acid transporter, sodium taurocholate co-transporting polypeptide (NTCP)...
May 22, 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29785584/interferon-free-therapy-in-hepatitis-c-virus-hcv-monoinfected-and-hcv-hiv-coinfected-patients-effect-on-cognitive-function-fatigue-and-mental-health
#2
Felix Kleefeld, Sophie Heller, Patrick Ingiliz, Heiko Jessen, Anders Petersen, Ute Kopp, Antje Kraft, Katrin Hahn
The efficacy and safety of interferon-free therapies for hepatitis C virus (HCV) infection have been reported. Considering the accumulating evidence for a direct central nervous system infection by HCV, we aim to evaluate the effect of direct acting antivirals (DAA) therapy on cognitive function in HCV patients. We conducted a longitudinal analysis of the cognitive performance of 22 patients (8 HCV+, 14 HCV+/HIV+) who completed neuropsychological testing at baseline and at week 12 after DAA therapy. In 20 patients, we analyzed specific attention parameters derived from an experimental testing based on the Theory of Visual Attention (TVA)...
May 21, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29778263/hepatitis-c-virus-elimination-in-the-human-immunodeficiency-virus-coinfected-population-leveraging-the-existing-human-immunodeficiency-virus-infrastructure
#3
REVIEW
Meredith E Clement, Lauren F Collins, Julius M Wilder, Michael Mugavero, Taryn Barker, Susanna Naggie
The objective of this review is to consider how existing human immunodeficiency virus (HIV) infrastructure may be leveraged to inform and improve hepatitis C virus (HCV) treatment efforts in the HIV-HCV coinfected population. Current gaps in HCV care relevant to the care continuum are reviewed. Successes in HIV treatment are then applied to the HCV treatment model for coinfected patients. Finally, the authors give examples of HCV treatment strategies for coinfected patients in both domestic and international settings...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778255/elimination-of-hepatitis-c-virus-in-australia-laying-the-foundation
#4
REVIEW
Gregory J Dore, Behzad Hajarizadeh
Australia is on-track to achieve World Health Organization hepatitis C virus (HCV) elimination targets. An active HCV screening program led to 82% of HCV-infected population being diagnosed. An unrestricted direct-acting antiviral (DAA) program, launched in March 2016 resulted in an estimated 58,500 individuals (26% of total HCV-infected population, including 70% of those with cirrhosis) initiating treatment through 2017. Treatment uptake was high among sub-populations at greater HCV transmission risk with 22% of people injecting drugs and >60% of those with HIV/HCV coinfection initiating DAA treatment in 2016...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29765442/hepatitis-c-coinfection-adversely-affects-the-life-expectancy-of-people-living-with-hiv-in-northwestern-poland
#5
Magdalena Leszczyszyn-Pynka, Piotr Ciejak, Katarzyna Maciejewska, Magdalena Witak-Jędra, Malwina Karasińska-Cieślak, Ewa Karpińska, Marta Wawrzynowicz-Syczewska, Miłosz Parczewski
Introduction: Hepatitis C (HCV) infection adversely affects survival among people living with HIV, increasing mortality risk due to liver-related causes. In Poland HCV is found among ~30% of HIV infected individuals, with only a small percentage successfully treated for this coinfection. This study aimed to analyze the HCV-associated influence on the life expectancy among HIV/HCV coinfected patients from northwestern Poland. Material and methods: Longitudinal data of 701 (368 HIV monoinfected and 368 HIV/HCV coinfected) patients were investigated to assess the life expectancy and survival after HIV diagnosis...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29759421/prevalence-and-distribution-of-hepatitis-c-virus-genotypes-in-galicia-during-the-period-2000-2015
#6
Daniel Navarro-de la Cruz, Sonia Pérez-Castro, Matilde Trigo-Daporta, Antonio Aguilera-Guirao
INTRODUCTION: We present the largest study conducted in Galicia on the prevalence and distribution of HCV genotypes/subtypes. METHODS: Retrospective study collecting the total number of patients chronically infected by HCV between 2000.01.01 to 2015.12.31 in 3of the main health areas: Santiago, Pontevedra and Vigo. RESULTS: We collected a total of 4469 patients. The median age was 50 years (IQR 57-45), 72,3% were men, 0,4% were coinfected with another genotype, 20,6% were coinfected with HIV and 35...
May 11, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29746648/effects-of-sofosbuvir-based-hepatitis-c-treatment-on-the-pharmacokinetics-of-tenofovir-in-hiv-hcv-coinfected-individuals-receiving-tenofovir-disoproxil-fumarate
#7
Christine E MacBrayne, Kristen M Marks, Daniel S Fierer, Susanna Naggie, Raymond T Chung, Michael D Hughes, Arthur Y Kim, Marion G Peters, Diana M Brainard, Sharon M Seifert, Jose R Castillo-Mancilla, Lane R Bushman, Peter L Anderson, Jennifer J Kiser
Background: The nucleotide analogues tenofovir and sofosbuvir are considered to have low potential for drug interactions. Objectives: To determine the effect of sofosbuvir-based HCV treatment on plasma concentrations of tenofovir and cellular concentrations of tenofovir diphosphate. Methods: HIV-infected participants with acute HCV were treated for 12 weeks with sofosbuvir + ribavirin in Cohort 1 or 8 weeks with ledipasvir/sofosbuvir in Cohort 2 of AIDS Clinical Trials Group study 5327...
May 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29742524/prevalence-and-incidence-of-hepatitis-delta-in-patients-with-chronic-hepatitis-b-in-spain
#8
Antonio Aguilera, Rocio Trastoy, Javier Rodríguez-Calviño, Tamara Manso, Carmen de Mendoza, Vicente Soriano
BACKGROUND: Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual HDV and hepatitis B virus exposure. Herein, we examined the global and incident rates of HDV infections in Spain. PATIENTS AND METHODS: The presence of anti-HDV antibody and new HDV superinfections was examined in all HBsAg+ patients who attended one large tertiary outclinic in Spain since year 2000...
May 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29727295/croi-2018-highlights-of-viral-hepatitis
#9
Anne F Luetkemeyer, David L Wyles
At the 2018 Conference on Retroviruses and Opportunistic Infections (CROI), there was a major focus on hepatitis C virus (HCV) elimination and improving each component of the hepatitis C care cascade. Several countries and cohorts have demonstrated the remarkable impact that universal HCV testing and unrestricted access to hepatitis C treatment can have on markedly reducing incident HCV infections and HCV infection prevalence, including in people who inject drugs and HIV/HCV-coinfected populations. However, in many settings, substantial barriers to widespread HCV treatment remain, including undiagnosed HCV infection, particularly in populations outside the standard "baby boomer" birth cohort (ie, born 1945-1965); restricted access to hepatitis C treatment in those with known HCV infection; reinfection with HCV; and migration of HCV-infected populations...
May 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29702515/integrated-care-for-the-use-of-direct-acting-antivirals-in-patients-with-chronic-hepatitis-c-and-substance-use-disorder
#10
Jean-Baptiste Trabut, Camille Barrault, Hélène Charlot, Damien Carmona, Anne Bourdel, Mustapha Benslimane, Murielle François, Willy Kini-Matondo, Richard Causse, Françoise Roudot-Thoraval, Christophe Hézode
OBJECTIVES: Since little is currently known about predictors of response to direct-acting antiviral agents (DAAs) in people who inject drugs, we undertook an analysis of patients attending a hepatitis clinic with addiction services (outpatient clinics and inpatient services) to examine the outcomes associated with the treatment of difficult-to-manage patients with substance use. Our experience was based on integrated care. METHOD: A retrospective analysis was undertaken of 50 patients with hepatitis C virus (HCV) and a history of addiction who received treatment with DAAs, according to European guidelines...
April 26, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29692581/cluster-of-differentiation-4-t-cell-counts-and-human-immunodeficiency-virus-1-viral-load-in-patients-coinfected-with-hepatitis-b-virus-and-hepatitis-c-virus
#11
Sakshee Gupta, Bharti Malhotra, Jitendra Kumar Tiwari, Prabhu Dayal Khandelwal, Rakesh Kumar Maheshwari
BACKGROUND: Coinfections of human immunodeficiency virus (HIV) with hepatitis viruses may affect the progress of disease and response to therapy. OBJECTIVES: To study the incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfections in HIV-positive patients and their influence on HIV-1 viral load and cluster of differentiation 4+ (CD4+) T-cell counts. MATERIALS AND METHODS: This pilot study was done on 179 HIV-positive patients attending antiretroviral therapy (ART) centre...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29665069/generic-velpatasvir-plus-sofosbuvir-for-hepatitis-c-virus-infection-in-patients-with-or-without-human-immunodeficiency-virus-coinfection
#12
C-H Liu, H-Y Sun, C-J Liu, W-H Sheng, S-M Hsieh, Y-C Lo, W-C Liu, T-H Su, H-C Yang, C-M Hong, T-C Tseng, P-J Chen, D-S Chen, C-C Hung, J-H Kao
BACKGROUND: Data are limited regarding the effectiveness and safety of generic velpatasvir plus sofosbuvir (VEL/SOF) for hepatitis C virus (HCV) in patients with or without human immunodeficiency virus (HIV) coinfection. AIM: To evaluate the effectiveness and safety of generic VEL/SOF-based therapy for HCV infection in patients with or without HIV coinfection in Taiwan. METHODS: Sixty-nine HIV/HCV-coinfected and 159 HCV-monoinfected patients receiving 12 weeks of generic VEL/SOF with or without ribavirin (RBV) for HCV were prospectively enrolled...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29642845/prognostic-value-of-liver-stiffness-in-hiv-hcv-coinfected-patients-with-decompensated-cirrhosis
#13
Leire Pérez-Latorre, Matilde Sánchez-Conde, Pilar Miralles, Juan Carlos López, Francisco Parras, Francisco Tejerina, Teresa Aldámiz-Echevarría, Ana Carrero, Cristina Díez, Margarita Ramírez, Isabel Gutiérrez, José María Bellón, Rafael Bañares, Juan Berenguer
BACKGROUND: Little is known about the utility of transient elastography (TE) for assessing the prognosis of patients with decompensated cirrhosis (DC). METHODS: We analyzed HIV/HCV-coinfected patients with DC who underwent TE as part of their routine follow-up between 2006 and 2015. We also calculated the liver stiffness spleen diameter-to-platelet score (LSPS), FIB-4 index, albumin, MELD score, and Child-Pugh score. The primary outcome was death. RESULTS: The study population comprised 65 patients...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29619424/liver-stiffness-measurement-predicted-liver-related-events-and-all-cause-mortality-a-systematic-review-and-nonlinear-dose-response-meta-analysis
#14
Junna Wang, Jiajun Li, Quan Zhou, Dandan Zhang, Qiu Bi, Yulin Wu, Wenxiang Huang
Numerous studies have investigated the prognosis value of the liver stiffness measurement (LSM) by transient elastography in assessing the risk of liver-related events (LREs) and all-cause mortality in patients with chronic liver disease (CLD). However, the shape of the dose-response relationship between them remains unclear. We searched PubMed, Embase, the Cochrane Library, and reference lists of articles for studies published up to July 1, 2017, that assessed the LSM in predicting LREs and all-cause mortality among subjects with CLD...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29596108/hepatocellular-carcinoma-after-sustained-virological-response-with-interferon-free-regimens-in-hiv-hcv-coinfected-patients
#15
Nicolás Merchante, Francisco Rodríguez-Arrondo, Boris Revollo, Esperanza Merino, Sofía Ibarra, María J Galindo, Marta Montero, Miguel García-Deltoro, Antonio Rivero-Juárez, Francisco Téllez, Marcial Delgado-Fernández, María J Ríos-Villegas, María A García, Francisco J Vera-Méndez, Guillermo Ojeda-Burgos, Miguel A López-Ruz, Luis Metola, Mohamed Omar, María Remedios Alemán-Valls, Koldo Aguirrebengoa, Joseba Portu, Miguel Raffo, Juan Macías, Juan A Pineda
OBJECTIVE: To assess the possible association between the use of direct antiviral agents (DAA) and the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients. METHODS: The GEHEP-002 cohort recruits HCC cases in HIV-infected patients from 32 centers from Spain. Three analyses were performed: the proportion of HCC cases after sustained virological response (SVR) and the evolution of this proportion over time, the frequency of HCC after SVR in HIV/HCV-coinfected patients with cirrhosis, and the probability of HCC recurrence after curative therapies among those undergoing HCV therapy...
March 28, 2018: AIDS
https://www.readbyqxmd.com/read/29595065/protease-inhibitor-therapy-for-hepatitis-c-virus-infection
#16
P de Leuw, C Stephan
The hepatitis C virus (HCV) has affected an estimated of 80 million individuals worldwide and is a strain on public health. Around 25-30% of patients in Europe and the US who are infected with HIV are coinfected with HCV. Prior to 2013, treatment modalities containing an NS3/4A protease inhibitor in combination with pegylated interferon and ribavirin improved sustained virological response (SVR) rates. However, rates of severe side effects were high. Nowadays, oral direct-acting antiviral (DAA) combination therapy offers excellent treatment efficacy, safety and tolerability...
April 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29556931/effectiveness-and-security-of-chronic-hepatitis-c-treatment-in-coinfected-patients-in-real-world
#17
Moisés Uriarte-Pinto, Herminia Navarro-Aznarez, Natalia De La Llama-Celis, Piedad Arazo-Garcés, Ana María Martínez-Sapiña, María Reyes Abad-Sazatornil
Background HIV-HCV coinfection produces high morbi-mortality. Direct-acting antivirals (DAAs) have shown high efficacy, although special attention should be paid to the risk of drug interactions. However, due to the lack of representativeness of coinfected patients in clinical trials, it is important to know real-world results. Objective To evaluate DAA treatment effectiveness in coinfected patients. We also analyse safety profile of DAA treatment and drug interactions between HCV and HIV therapy. Setting Descriptive study carried in a tertiary hospital of Spain Method HIV-HCV coinfected patients treated with DAAs between November 2014 and June 2016 were included...
March 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29547441/role-of-toll-like-receptor-4-asp299gly-polymorphism-in-the-development-of-cardiovascular-diseases-in-hiv-infected-patients
#18
Laura Tarancon-Diez, Rebeca S De Pablo-Bernal, José L Jiménez, Ana I Álvarez-Ríos, Miguel Genebat, Isaac Rosado-Sánchez, María-Ángeles Muñoz-Fernández, Ezequiel Ruiz-Mateos, Manuel Leal
OBJECTIVE: Cardiovascular diseases (CVDs) are one of the main causes of morbimortality in HIV-infected patients on suppressive antiretroviral therapy. The objective of this work was to evaluate the role of single nucleotide polymorphisms (SNPs) in lipopolysaccharide (LPS) Toll-like receptor 4 (TLR4) and CVDs occurrence in HIV-infected patients. Additionally, the functional consequences of carrying these SNPs were analyzed. METHODS: The association of TLR4 SNPs, Asp299Gly/Thr399Ile with CVDs occurrence was analyzed using multivariate logistic regression models...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29529669/risk-of-complications-after-tha-increases-among-patients-who-are-coinfected-with-hiv-and-hepatitis-c
#19
Siddharth A Mahure, Joseph A Bosco, James D Slover, Jonathan Vigdorchik, Richard Iorio, Ran Schwarzkopf
BACKGROUND: Individuals coinfected with both hepatitis C virus (HCV) and HIV represent a unique and growing population of patients undergoing orthopaedic surgical procedures. Data regarding complications for HCV monoinfection or HIV monoinfection are robust, but there are no data available, to our knowledge, on patients who have both HCV and HIV infections. QUESTIONS/PURPOSES: We sought to determine whether patients with coinfection differed in terms of baseline demographics and comorbidity burden as compared with patients without coinfection and whether these potential differences were translated into varying levels of postoperative complications, mortality, and hospital readmission risk...
February 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29528417/no-effect-of-pegylated-interferon-alpha-on-total-hiv-1-dna-load-in-hiv-1-hcv-coinfected-patients
#20
Victoria P Strouvelle, Dominique L Braun, Valentina Vongrad, Alexandra U Scherrer, Yik Lim Kok, Roger D Kouyos, Marcel Stöckle, Andri Rauch, Katharine Darling, Matthias Hoffmann, Karin J Metzner, Huldrych F Günthard
Pegylated interferon-alpha (pIFN-α) is suggested to lower HIV-1 DNA load in antiretroviral therapy (ART) treated patients. We studied the kinetics of total HIV-1 DNA levels in 40 HIV-1/hepatitis C (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into three groups according to start of ART: Chronic HIV-1 infection (n=22), acute HIV-1 infection (n=8), no-ART (n=10). Total HIV-1 DNA levels were quantified in 247 PBMC samples and remained stable before, during, and after pIFN-α treatment in all three groups...
March 8, 2018: Journal of Infectious Diseases
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