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Annie Bourdeau, Paul Van Slyke, Harold Kim, Maribelle Cruz, Tracy Smith, Daniel J Dumont
BACKGROUND: Earlier studies by our group have demonstrated that a transgenic animal engineered to express Tie2 under the control of the Tie2 promoter produced animals with a scaly skin phenotype that recapitulated many of the hallmarks of atopic dermatitis (AT-Derm). To test the hypothesis that this model of AT-Derm is driven by dysregulated Tie2-signalling, we have bred AT-Derm transgenic (TG) animals with TG-animals engineered to overexpress Angiopoietin-1 or -2, the cognate Tie2 ligands...
2016: BMC Research Notes
Patrick Micheels, Didier Sarazin, Christian Tran, Denis Salomon
BACKGROUND: The mechanical, rheological, and pharmacological properties of hyaluronic acid (HA) gels differ by their proprietary crosslinking technologies.<BR /> OBJECTIVE: To examine the different properties of a range of HA gels using simple and easily reproducible laboratory tests to better understand their suitability for particular indications.<BR /> METHODS AND MATERIALS: Hyaluronic acid gels produced by one of 7 different crosslinking technologies were subjected to tests for cohesivity, resistance to stretch, and microscopic examination...
May 1, 2016: Journal of Drugs in Dermatology: JDD
Abigail T Berman, Cristina M DeCesaris, Charles B Simone, Carolyn Vachani, Gloria DiLullo, Margaret K Hampshire, James Metz, Christine Hill-Kayser
PURPOSE: Lung cancer is the leading cause of cancer death and is a significant source of morbidity. Patient-reported outcomes (PROs) have been shown to be prognostic for survival. We have analyzed emerging patterns of longitudinal PROs collected in the development of survivorship care plans (SCPs). METHODS: OncoLife and the LIVESTRONG Care Plans are Internet-based programs designed to generate unique SCPs. We selected SCPs from patients identifying as survivors of primary lung cancer...
May 2016: Journal of Oncology Practice
Heidi K St John, Melissa L Adams, Penny M Masuoka, Johanna G Flyer-Adams, Ju Jiang, Patrick J Rozmajzl, Ellen Y Stromdahl, Allen L Richards
Rickettsia montanensis has long been considered a nonpathogenic member of the spotted fever group rickettsiae. However, the infection potential of R. montanensis is being revisited in light of its recent association with a case of human infection in the United States and the possibility that additional cases may have been misdiagnosed as Rocky Mountain spotted fever. To this end, DNA was extracted from American dog ticks (Dermacentor variabilis) removed from Department of Defense (DoD) personnel and their dependents at DoD medical treatment facilities (MTFs) during 2002-2012 (n = 4792)...
April 2016: Vector Borne and Zoonotic Diseases
B Burkey, W Davis, P M Glat
OBJECTIVE: Porcine xenograft (PX) has become a valuable part of the armamentarium of treatment options in a US paediatric burn centre. The use in adult patients has been well described in the burn literature, but there is minimal literature describing its use in children. The objective of this article is to describe a three-years' experience with PX use in paediatric burns. METHOD: A retrospective medical record review of patients with superficial partial-thickness burns treated with PX admitted to a paediatric burn centre between February 2009 and November 2012...
February 2016: Journal of Wound Care
Rameshwari Thakur, Roma Goyal
Tinea capitis is a common dermatophyte infection affecting scalp and hair of pre-pubertal children. With introduction of Griseofulvin in 1958, there has been considerable improvement in the treatment of tinea capitis. A seven-year-old male child was brought to the dermatology clinic. He presented with diffuse white scaly patches of alopecia on scalp of one-year duration. The child was sent to the microbiology section of the National Health laboratory, Botswana for the collection of the samples. The samples consisted of scalp scrapings and few plucked hairs from the suspicious areas, which were collected by swab and scalpel blade methods...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
Lisa Byrom, Lex Lucas, Vicki Sheedy, Kim Madison, Lachlan McIver, George Castrisos, Christina Alfonzo, Frank Chiu, Jim Muir
OBJECTIVE: To identify the current scope of Tele-Derm, the types of dermatological complaints experienced in the rural primary care setting, and to assess the quality of patient clinical information provided to the consultant dermatologist. DESIGN: Retrospective case analysis. SETTING: Tele-Derm National is an initiative of the Australian College of Rural and Remote Medicine and has been providing online educational and consultational services in dermatology to doctors Australia-wide for over a decade...
June 2016: Australian Journal of Rural Health
Roger Esteban-Vives, Matthew T Young, Jenny Ziembicki, Alain Corcos, Jörg C Gerlach
Autologous cell-spray grafting of non-cultured epidermal cells is an innovative approach for the treatment of severe second-degree burns. After treatment, wounds are covered with dressings that are widely used in wound care management; however, little is known about the effects of wound dressings on individually isolated cells. The sprayed cells have to actively attach, spread, proliferate, and migrate in the wound for successful re-epithelialization, during the healing process. It is expected that exposure to wound dressing material might interfere with cell survival, attachment, and expansion...
February 2016: Burns: Journal of the International Society for Burn Injuries
Marialuisa Framarino-dei-Malatesta, Giuseppina Perrone, Antonella Giancotti, Flavia Ventriglia, Martina Derme, Isabella Iannini, Valentina Tibaldi, Paola Galoppi, Paolo Sammartino, Gianluca Cascialli, Roberto Brunelli
BACKGROUND: Current knowledge indicate that epirubicin administration in late pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin pregnancy complicated by breast cancer in which epirubicin administration was causatively linked to the death of one twin who was small for gestational age (SGA) and in a condition of oligohydramnios and determined the onset of a transient cardiotoxicity of the surviving fetus/newborn. CASE PRESENTATION: A 38-year-old caucasic woman with a dichorionic twin pregnancy was referred to our center at 20 and 1/7 weeks for a suspected breast cancer, later confirmed by the histopathology report...
2015: BMC Cancer
Hervé Raspaldo, Jonquille Chantrey, Lakhdar Belhaouari, David Eccleston, Roy Saleh, Raj Acquilla, Diane K Murphy
BACKGROUND: Juvéderm® Volbella® with Lidocaine is a hyaluronic acid filler suited for lip enhancement. OBJECTIVE: Evaluate the safety and effectiveness of Juvéderm Volbella with Lidocaine versus non-animal stabilized hyaluronic acid with lidocaine (Restylane-L®). METHODS: This study randomized 280 subjects desiring lip enhancement to Juvéderm Volbella with Lidocaine or Restylane-L. Investigators rated outcomes using Allergan's Lip Fullness Scale (LFS), Perioral Lines Severity Scale, and Oral Commissures Severity Scale...
December 2015: Journal of Drugs in Dermatology: JDD
Arash Mostaghimi, Karolyn Wanat, Bradley H Crotty, Misha Rosenbach
IMPORTANCE: In response to a perceived erosion of medical dermatology, combined internal medicine and dermatology programs (med/derm) programs have been developed that aim to train dermatologists who take care of medically complex patients. Despite the investment in these programs, there is currently no data with regards to the potential impact of these trainees on the dermatology workforce. OBJECTIVE: To determine the experiences, motivations, and future plans of residents in combined med/derm residency programs...
October 2015: Dermatology Online Journal
R M Andersen, J P Thyssen, H I Maibach
This review summarizes historical aspects, clinical expression and pathophysiology leading to coining of the terms atopy and atopic dermatitis, current diagnostic criteria and further explore the possibility of developing quantitative diagnostic criteria of atopic dermatitis (AD) based on the importance of atopic features - subjective, objective, and those derived from laboratory tests - the new partly promising AD biomarkers. 'Atopy', introduced in 1923, denoted 'the sense of a strange disease without a precise place in the body'...
April 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Gabriele Masselli, Martina Derme, Francesca Laghi, Marialuisa Framarino-dei-Malatesta, Gianfranco Gualdi
Acute abdominal pain in pregnancy presents diagnostic and therapeutic challenges. Ultrasound remains the primary imaging investigation of the pregnant abdomen because of its availability, portability, and lack of ionizing radiation. MR imaging has been shown to be useful in the diagnosis of gynecologic and obstetric problems and in the setting of acute abdomen during pregnancy. MR imaging is often used when ultrasound is inconclusive. Computed tomography is the investigation of choice when there is a life-threatening situation and in case of traumatic injuries, when a rapid diagnosis is required...
November 2015: Radiologic Clinics of North America
Jaclyn Smith, Steven R Feldman
No abstract text is available yet for this article.
2015: Journal of Dermatological Treatment
Ichiro Harasawa, Joshua P Johansen, Howard L Fields, Frank Porreca, Ian D Meng
The rostral ventromedial medulla (RVM) exerts both inhibitory and excitatory controls over nociceptive neurons in the spinal cord and medullary dorsal horn. Selective ablation of mu-opioid receptor (MOR)-expressing neurons in the RVM using saporin conjugated to the MOR agonist dermorphin-saporin (derm-sap) attenuates stress and injury-induced behavioral hypersensitivity, yet the effect of RVM derm-sap on the functional integrity of the descending inhibitory system and the properties of RVM neurons remain unknown...
January 2016: Pain
Elena Ortona, Tania Colasanti, Martina Derme, Isabella Iannini, Marta Vomero, Maurizio Sorice, Francesca D'Alessandro, Alessandro Nanni Costa, Walter Malorni, Giuseppe Orlando, Marialuisa Framarino-dei-Malatesta
No abstract text is available yet for this article.
September 2015: Transplantation
Jenine K Sanzari, Eric S Diffenderfer, Sarah Hagan, Paul C Billings, Daila S Gridley, John T Seykora, Ann R Kennedy, Keith A Cengel
The space environment exposes astronauts to risks of acute and chronic exposure to ionizing radiation. Of particular concern is possible exposure to ionizing radiation from a solar particle event (SPE). During an SPE, magnetic disturbances in specific regions of the Sun result in the release of intense bursts of ionizing radiation, primarily consisting of protons that have a highly variable energy spectrum. Thus, SPE events can lead to significant total body radiation exposures to astronauts in space vehicles and especially while performing extravehicular activities...
July 2015: Life Sciences in Space Research
Roberta Priori, Antonina Minniti, Martina Derme, Barbara Antonazzo, Filippo Brancatisano, Silvia Ghirini, Guido Valesini, Marialuisa Framarino-dei-Malatesta
OBJECTIVE: To assess the quality of sexual life of women with primary Sjögren syndrome (pSS) and to identify its correlations with disease activity and damage, quality of life, and mood disorders. METHODS: The quality of sexual life of 24 women with pSS was assessed with the Female Sexual Function Index (FSFI). Twenty-four healthy women, matched by age and hormonal status, were enrolled as controls. Mood disorders and quality of life were investigated using the Hospital Anxiety and Depression Scale (HADS) and the Medical Outcomes Study Short Form-36...
August 2015: Journal of Rheumatology
Ryan C Murray, Mary C Logan, Kristen A Horner
Stereotypy can be characterized as inflexible, repetitive behaviors that occur following repeated exposure to psychostimulants, such as cocaine (COC). Stereotypy may be related to preferential activation of the patch (striosome) compartment of striatum, as enhanced relative activation of the patch compartment has been shown to positively correlate with the emergence of stereotypy following repeated psychostimulant treatment. However, the specific contribution of the patch compartment to COC-induced stereotypy following repeated exposure is unknown...
August 27, 2015: Brain Research
Camilo Lesmes-Fabian, Camilo Lesmes Fabian, Claudia R Binder
In the field of occupational hygiene, researchers have been working on developing appropriate methods to estimate human exposure to pesticides in order to assess the risk and therefore to take the due decisions to improve the pesticide management process and reduce the health risks. This paper evaluates dermal exposure models to find the most appropriate. Eight models (i.e., COSHH, DERM, DREAM, EASE, PHED, RISKOFDERM, STOFFENMANAGER and PFAM) were evaluated according to a multi-criteria analysis and from these results five models (i...
May 2015: International Journal of Environmental Research and Public Health
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