Bradley W Tuft, Linjing Xu, Scott P White, Alison E Seline, Andrew M Erwood, Marlan R Hansen, C Allan Guymon
Overcoming signal resolution barriers of neural prostheses, such as the commercially available cochlear impant (CI) or the developing retinal implant, will likely require spatial control of regenerative neural elements. To rationally design materials that direct nerve growth, it is first necessary to determine pathfinding behavior of de novo neurite growth from prosthesis-relevant cells such as spiral ganglion neurons (SGNs) in the inner ear. Accordingly, in this work, repeating 90° turns were fabricated as multidirectional micropatterns to determine SGN neurite turning capability and pathfinding...
July 23, 2014: ACS Applied Materials & Interfaces