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JOURNAL ARTICLE
Massimiliano Polastri, Allaina Eden, Justyna Swol
BACKGROUND AND PURPOSE: Current information on the latest rehabilitative practices is limited, with previous reviews only covering data up to October 2021, and some considering only patients on awake ECMO or with COVID-19. This review aims to present a concise overview of the latest findings on rehabilitation and highlight emerging trends for patients undergoing ECMO support. METHODS: This integrative review was conducted by searching the National Library of Medicine - PubMed database...
April 2024: Perfusion
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JOURNAL ARTICLE
Shahriyar Shahbazi Khamas, Yoni Van Dijk, Mahmoud I Abdel-Aziz, Anne H Neerincx, Jelle Blankestijn, Susanne J H Vijverberg, Simone Hashimoto, Andrew Bush, Aletta D Kraneveld, Anna M Hedman, Antoaneta A Toncheva, Catarina Almqvist, Christine Wolff, Clare S Murray, Gunilla Hedlin, Graham Roberts, Ian M Adcock, Javier Korta-Murua, Klaus Bønnelykke, Louise J Fleming, Maria Pino-Yanes, Mario Gorenjak, Michael Kabesch, Olaia Sardón-Prado, Paolo Montuschi, Florian Singer, Paula Corcuera-Elosegui, Stephen J Fowler, Susanne Brandstetter, Susanne Harner, Sven-Erik Dahlén, Uroš Potočnik, Urs Frey, Wim van Aalderen, Paul Brinkman, Anke H Maitland-van der Zee
RATIONALE: Early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. OBJECTIVES: To assess the accuracy of gas chromatography-mass spectrometry based exhaled metabolite analysis to differentiate between controlled and uncontrolled pediatric asthma. METHODS: This study encompassed a discovery (SysPharmPediA) and validation phase (U-BIOPRED, PANDA)...
April 22, 2024: American Journal of Respiratory and Critical Care Medicine
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JOURNAL ARTICLE
Anja Große Lordemann, Dirk Sommerfeldt, Lukas Mileder
INTRODUCTION: Structured emergency room concepts have been shown to contribute to patient safety. Until now there has been no uniform emergency room concept for critically ill and seriously injured children and adolescents in the emergency room at the Altona Children's Hospital in Hamburg. This concept has been newly developed in interdisciplinary cooperation and includes the use of new clinical premises as well as new responsibilities and team compositions. The introduction of new processes and rooms for handling emergencies is associated with a risk of overlooking latent safety deficiencies or detecting them only after the process has been implemented...
April 20, 2024: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
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JOURNAL ARTICLE
Malini Maya, Ramachandran Rameshkumar, Tamil Selvan, Chinnaiah Govindhareddy Delhikumar
OBJECTIVES: To compare high-flow nasal cannula (HFNC) versus nasal prong bubble continuous positive airway pressure (b-CPAP) in children with moderate to severe acute bronchiolitis. DESIGN: A randomized controlled trial was carried out from August 2019 to February 2022. (Clinical Trials Registry of India number CTRI/2019/07/020402). SETTING: Pediatric emergency ward and ICU within a tertiary care center in India. PATIENTS: Children 1-23 months old with moderate to severe acute bronchiolitis...
April 19, 2024: Pediatric Critical Care Medicine
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JOURNAL ARTICLE
Khalid A Alkheraije
BACKGROUND: Antimicrobial resistance (AMR) is recognized globally as a significant health challenge, but its extent remains unclear in many regions. It is crucial to prioritize a foundational evaluation of AMR prevalence to facilitate the implementation of laboratory-based surveillance. Adopting a One Health perspective, this study outlines the present AMR status in the Middle East. AIM: To synthesize the current state of knowledge on AMR in the Middle East, delineate the contributions of different sectors (human health, animal health, and environment), and discern the effectiveness of One Health interventions in mitigating AMR...
January 2024: Open Veterinary Journal
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JOURNAL ARTICLE
Wakato Matsuoka, Soichi Mizuguchi, Noriyuki Kaku, Kanako Higashi, Kenichi Tetsuhara, Tomohiko Akahoshi, Shouichi Ohga
OBJECTIVES: To develop an equation for defining a low skeletal muscle mass (SMM) in children and to investigate risk factors and outcomes associated with low SMM in critically ill pediatric patients. DESIGN: Single-center retrospective pediatric cohorts, 2011-2018. SETTING: Tertiary Emergency and Critical Care Center of Kyushu University Hospital in Japan. PATIENTS: We studied two cohorts of pediatric patients 1-15 years old who underwent abdominal CT at the level of the third lumbar vertebra (L3)...
April 17, 2024: Pediatric Critical Care Medicine
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JOURNAL ARTICLE
Robert Darnell, Alanna Brown, Emma Laing, Julia Edwards, David A Harrison, Joseph C Manning, Mark J Peters, Padmanabhan Ramnarayan, Samiran Ray, Zia Sadique, Barnaby R Scholefield, Dermot Shortt, Lamprini Lampro, Carly Au, Kathy M Rowan, Paul Mouncey, David P Inwald
OBJECTIVES: Management of hypotension is a fundamental part of pediatric critical care, with cardiovascular support in the form of fluids or vasoactive drugs offered to every hypotensive child. However, optimal blood pressure (BP) targets are unknown. The PRotocolised Evaluation of PermiSSive BP Targets Versus Usual CaRE (PRESSURE) trial aims to evaluate the clinical and cost-effectiveness of a permissive mean arterial pressure (MAP) target of greater than a fifth centile for age compared with usual care...
April 17, 2024: Pediatric Critical Care Medicine
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JOURNAL ARTICLE
Sarah C Cavallaro, Sara Schutzman, Joyce Li, Martin Pusic
BACKGROUND: Currently, the Accreditation Council of Graduate Medical Education requires time-based pediatric experiences for emergency medicine (EM) residents in both pediatric emergency medicine (PEM) and critical care settings. The American Board of Emergency Medicine has published the Model of the Clinical Practice of Emergency Medicine, which is a list of content an EM resident should learn. However, this list is large and without prioritization and therefore can be difficult to incorporate into time-limited curricula...
April 2024: AEM Education and Training
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JOURNAL ARTICLE
Simonetta Costa, Irma Capolupo, Luca Bonadies, Michele Quercia, Maria Pasqua Betta, Sara Gombos, Costanza Tognon, Giacomo Cavallaro, Stefania Sgrò, Roberta Pastorino, Denise Pires Marafon, Andrea Dotta, Giovanni Vento
PURPOSE: Few guidelines exist for the perioperative management (PM) of neonates with surgical conditions (SC). This study examined the current neonatal PM in Italy. METHODS: We invited 51 neonatal intensive care units with pediatric surgery in their institution to participate in a web-based survey. The themes included (1) the involvement of the neonatologist during the PM; (2) the spread of bedside surgery (BS); (3) the critical issues concerning the neonatal PM in operating rooms (OR) and the actions aimed at improving the PM...
April 16, 2024: Pediatric Surgery International
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JOURNAL ARTICLE
Maya W Keuning, Nikki N Klarenbeek, Hidde J Bout, Amber Broer, Melvin Draaijer, Jeroen Hol, Nina Hollander, Marieke Merelle, Nassar-Sheikh Nassar-Sheikh Rashid, Charlotte Nusman, Emma Oostenbroek, Milan L Ridderikhof, Manouck Roelofs, Ellen van Rossem, Sophie R D van der Schoor, Sarah M Schouten, Pieter Taselaar, Koen Vasse, Anne-Marie van Wermeskerken, Julia M J van der Zande, Roy Zuurbier, Merijn W Bijlsma, Dasja Pajkrt, Frans B Plötz
UNLABELLED: Evaluation of guidelines in actual practice is a crucial step in guideline improvement. A retrospective evaluation of the Dutch guideline for children with fever without an apparent source (FWS) showed 50% adherence in young infants. We prospectively evaluated adherence to the Dutch guideline and its impact on management in current practice. Prospective observational multicenter cross-sectional study, including children 3 days to 16 years old presented for FWS at one of seven emergency departments in participating secondary and tertiary care hospitals in the Netherlands...
April 15, 2024: European Journal of Pediatrics
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EDITORIAL
Gurpreet S Dhillon, Marc D Berg
No abstract text is available yet for this article.
May 1, 2024: Critical Care Medicine
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JOURNAL ARTICLE
Sameer Bhatia, Swasti Pal, Samarth Kulshrestha, Dhiren Gupta, Arun Soni, Renu Saxena, Sunita Bijarnia-Mahay, Ishwar Chander Verma, Ratna Dua Puri
Next generation sequencing based diagnosis has emerged as a promising tool for evaluating critically ill neonates and children. However, there is limited data on its utility in developing countries. We assessed its diagnostic rate and clinical impact on management of pediatric patients with a suspected genetic disorder requiring critical care. The study was conducted at a single tertiary hospital in Northern India. We analyzed 70 children with an illness requiring intensive care and obtained a precise molecular diagnosis in 32 of 70 probands (45...
April 11, 2024: European Journal of Human Genetics: EJHG
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JOURNAL ARTICLE
Brittany A Petros, Carly E Milliren, Pardis C Sabeti, Al Ozonoff
BACKGROUND: Respiratory syncytial virus (RSV) circulation dropped markedly early in the COVID-19 pandemic, followed by a resurgence with heightened case counts. The "immunity debt" hypothesis proposes that the RSV-naїve pediatric population increased during the period of low transmission. However, the evidence supporting this hypothesis is limited, and the role of changing testing practices in the perceived surge has not been comprehensively evaluated. METHODS: We conducted a multicenter, retrospective analysis of 342 530 RSV encounters and 980 546 RSV diagnostic tests occurring at 32 US pediatric hospitals in 2013-2023...
April 11, 2024: Clinical Infectious Diseases
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JOURNAL ARTICLE
Kaileen Jafari, Kristen Carlin, Derya Caglar, Eileen J Klein, Tamara D Simon
INTRODUCTION: Most pediatric emergency care occurs in general emergency departments (GED), where less pediatric experience and lower pediatric emergency readiness may compromise care. Medically vulnerable pediatric patients, such as those with chronic, severe, neurologic conditions, are likely to be disproportionately affected by suboptimal care in GEDs; however, little is known about characteristics of their care in either the general or pediatric emergency setting. In this study our objective was to compare the frequency, characteristics, and outcomes of ED visits made by children with chronic neurologic diseases between general and pediatric EDs (PED)...
March 2024: Western Journal of Emergency Medicine
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JOURNAL ARTICLE
Elissa Abou Khalil, Erin Feeney, Katrina M Morgan, Philip C Spinella, Barbara A Gaines, Christine M Leeper
INTRODUCTION: Admission hypocalcemia has been associated with poor outcomes in injured adults. The impact of hypocalcemia on mortality has not been widely studied in pediatric trauma. METHODS: A pediatric trauma center database was queried retrospectively (2013-2022) for children age < 18 years who received blood transfusion within 24 hours of injury and had ionized calcium (iCal) level on admission. Children who received massive transfusion (>40 mL/kg) prior to hospital arrival or calcium prior to laboratory testing were excluded...
April 8, 2024: Journal of Trauma and Acute Care Surgery
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JOURNAL ARTICLE
Management of youth with suicidal ideation: Challenges and best practices for emergency departments.
Genevieve Santillanes, Ashley A Foster, Paul Ishimine, Kathleen Berg, Tabitha Cheng, Ann Deitrich, Melanie Heniff, Gwen Hooley, Christian Pulcini, Timothy Ruttan, Annalise Sorrentino, Muhammad Waseem, Mohsen Saidinejad
Suicide is a leading cause of death among youth, and emergency departments (EDs) play an important role in caring for youth with suicidality. Shortages in outpatient and inpatient mental and behavioral health capacity combined with a surge in ED visits for youth with suicidal ideation (SI) and self-harm challenge many EDs in the United States. This review highlights currently identified best practices that all EDs can implement in suicide screening, assessment of youth with self-harm and SI, care for patients awaiting inpatient psychiatric care, and discharge planning for youth determined not to require inpatient treatment...
April 2024: Journal of the American College of Emergency Physicians open
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JOURNAL ARTICLE
Jinlan Zhou, Gangfeng Yan, Chengkang Tang, Jing Liu, Pan Fu, Li Ding, Weiwei Yang, Yan Guo, Chuanqing Wang, Guoping Lu, Fupin Hu
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses immense threats to the health of infected patients worldwide, especially in children. This study reports the infection caused by CRKP in a pediatric intensive care unit (PICU) child and its drug-resistant mutation during the treatment. Twelve Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains were isolated from the child. Broth microdilution method, plasmid transformation assay, and whole genome sequencing (WGS) were performed to investigate the antimicrobial susceptibility, resistance mechanisms, and genetic structural features of CRKPs...
April 1, 2024: International Journal of Antimicrobial Agents
#18
Jessica Gold, Colleen M Kripke, Theodore G Drivas
Numerous studies have underscored the diagnostic and therapeutic potential of exome or genome sequencing in critically ill pediatric populations. However, an equivalent investigation in critically ill adults remains conspicuously absent. We retrospectively analyzed whole exome sequencing (WES) data available through the PennMedicine Biobank (PMBB) from all 365 young adult patients, aged 18-40 years, with intensive care unit (ICU) admissions at the University of Pennsylvania Health System who met inclusion criteria for our study...
March 15, 2024: medRxiv
#19
Marie-Louis Wronski, Ralf Kuja-Halkola, Elin Hedlund, Miriam I Martini, Paul Lichtenstein, Sebastian Lundström, Henrik Larsson, Mark J Taylor, Nadia Micali, Cynthia M Bulik, Lisa Dinkler
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder, characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with a range of psychiatric and somatic symptoms, and therefore consult various pediatric subspecialties; large-scale studies mapping comorbidities are however lacking. To characterize health care needs of people with ARFID, we systematically investigated ARFID-related mental and somatic conditions in 616 children with ARFID and >30,000 children without ARFID...
March 15, 2024: medRxiv
#20
JOURNAL ARTICLE
Rizwan Qureshi, Azhar Iqbal, Sunitha Siddanna, Ujala Siddeeq, Farah Mushtaq, Bilal Arjumand, Osama Khattak, Saqib Sarfarz, Naif Abdulrahman Naif Aljunaydi, Abdulrahman Muharrab Mohammed Alkhaldi, Mosa Altassan, Esraa Ahmed Attar, Rakhi Issrani, Namdeo Prabhu
Tooth avulsion is a frequently encountered dental emergency. Children are commonly reported group due to frequent sports activities, trauma, accidents and falls. Prompt emergency management is vital for long term success and to avoid morbidity. The study was aimed to assess the understanding of intern dentists about the emergency handling of avulsed teeth cases as mostly they are first responders among health care personnel. In this study a fourteen-item questionnaire with predefined responses was shared as online Google survey form with intern dentists of 5 different dental teaching hospitals of Islamabad, Pakistan...
March 2024: Journal of Clinical Pediatric Dentistry
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