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https://www.readbyqxmd.com/read/29760063/elastic-coupling-power-stroke-mechanism-of-the-f-1-atpase-molecular-motor
#1
James L Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D Frasch
The angular velocity profile of the 120° F1 -ATPase power stroke was resolved as a function of temperature from 16.3 to 44.6 °C using a ΔμATP = -31.25 k B T at a time resolution of 10 μs. Angular velocities during the first 60° of the power stroke (phase 1) varied inversely with temperature, resulting in negative activation energies with a parabolic dependence. This is direct evidence that phase 1 rotation derives from elastic energy (spring constant, κ = 50 k B T ·rad-2 ). Phase 2 of the power stroke had an enthalpic component indicating that additional energy input occurred to enable the γ-subunit to overcome energy stored by the spring after rotating beyond its 34° equilibrium position...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29753079/curative-transvenous-embolization-for-ruptured-brain-arteriovenous-malformations-a-single-center-experience-from-china
#2
Yingkun He, Weixing Bai, Tianxiao Li, Ferdinand K Hui, Yanyan He, Bin Xu
OBJECTIVE: To evaluate the feasibility and safety of transvenous embolization treatment for brain arteriovenous malformations (bAVM). METHODS: Between November 2016 and August 2017, a transvenous endovascular embolization protocol was implemented at the Henan Provincial People's Hospital for consecutive patients with ruptured bAVM. Therapeutic decision making was based on Spetzler-Martin grades, bAVM location, pattern of venous drainage, and angioarchitecture. And the transvenous embolization procedure was combined with transarterial support...
May 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751183/onyx-embolization-before-the-surgical-treatment-of-grade-iii-spetzler-martin-brain-arteriovenous-malformations-single-center-experience-and-technical-nuances
#3
S Luzzi, M Del Maestro, D Bongetta, C Zoia, A V Giordano, D Trovarelli, Dehcordi S Raysi, R J Galzio
BACKGROUND: grade-III Spetzler-Martin (SM) brain arteriovenous malformations (AVMs) are a specific set of AVMs with a high variability in terms of site, size, angioarchitecture, flow dynamics and involvement of eloquent areas. Surgery preceded by pre-operative embolization has been reported as a useful treatment option for these lesions. The aim of this study is to report outcomes and personal experience of combined pre-operative Onyx embolization and surgical resection on a consecutive series of grade-III brain AVMs...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29733392/the-application-of-the-novel-grading-scale-lawton-young-grading-system-to-predict-the-outcome-of-brain-arteriovenous-malformation
#4
Ahmad Hafez, Päivi Koroknay-Pál, Elias Oulasvirta, Ahmed Abou Elseoud, Michael T Lawton, Mika Niemelä, Aki Laakso
BACKGROUND: A supplementary grading scale (Supplemented Spetzler-Martin grade, Supp-SM) was introduced in 2010 as a refinement of the SM system to improve preoperative risk prediction of brain arteriovenous malformations (AVMs). OBJECTIVE: To determine the ability to predict surgical outcomes using the Supp-SM grading scale. METHODS: This retrospective study was conducted on 200 patients admitted to the Helsinki University Hospital between 2000 and 2014...
May 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29728873/modern-radiosurgical-and-endovascular-classification-schemes-for-brain-arteriovenous-malformations
#5
REVIEW
Ali Tayebi Meybodi, Michael T Lawton
Stereotactic radiosurgery (SRS) and endovascular techniques are commonly used for treating brain arteriovenous malformations (bAVMs). They are usually used as ancillary techniques to microsurgery but may also be used as solitary treatment options. Careful patient selection requires a clear estimate of the treatment efficacy and complication rates for the individual patient. As such, classification schemes are an essential part of patient selection paradigm for each treatment modality. While the Spetzler-Martin grading system and its subsequent modifications are commonly used for microsurgical outcome prediction for bAVMs, the same system(s) may not be easily applicable to SRS and endovascular therapy...
May 4, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29685412/posterior-fossa-avms-increased-risk-of-bleeding-and-worse-outcome-compared-to-supratentorial-avms
#6
Nazife Dinc, Johannes Platz, Stephanie Tritt, Johanna Quick-Weller, Michael Eibach, Robert Wolff, Joachim Berkefeld, Volker Seifert, Gerhard Marquardt
Infratentorial AVMs are often considered as potentially hazardous as they are thought to present more often with hemorrhage, may harbor AVM-associated aneurysms more frequently and to be associated with poor outcome. The aim of our study is to compare features of supratentorial and infratentorial AVMs. We retrospectively analyzed 316 consecutive patients with cerebral AVM presenting to our neurovascular center between 2005 and 2015. Location and angioarchitecture of the AVM including AVM-associated aneurysms, bleeding events, and outcome during follow up were analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29660051/resection-of-right-frontal-arteriovenous-malformation-3-dimensional-operative-video
#7
William T Couldwell
The video demonstrates resection of a Grade II Spetzler-Martin unruptured, medium-sized arteriovenous malformation (AVM). A young woman presented with headaches and seizures. The right frontal lesion measured 4.5 cm in largest dimension and had superficial venous drainage. Partial Onyx embolization, primarily of the anterior cerebral feeding arteries, was performed. Bone removal for exposure allowed identification of indentation from the large superficial draining vein. The video demonstrates careful microsurgical dissection on the AVM/brain interface, with selective interruption of feeding arteries circumferentially...
April 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29611866/gamma-knife-radiosurgery-for-arteriovenous-malformations-general-principles-and-preliminary-results-in-a-swiss-cohort
#8
Matthieu Raboud, Constantin Tuleasca, Philippe Maeder, Luis Schiappacasse, Maud Marguet, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Arteriovenous malformations (AVMs) are a type of vascular malformation characterised by an abnormal connection between arteries and veins, bypassing the capillary system. This absence of capillaries generates an elevated pressure (hyperdebit), in both the AVM and the venous drainage, increasing the risk of rupture. Management modalities are: observation, microsurgical clipping, endovascular treatment and radiosurgery. The former can be used alone or in the frame of a multidisciplinary approach...
April 3, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29604508/conventional-digital-subtractional-vs-non-invasive-mr-angiography-in-the-assessment-of-brain-arteriovenous-malformation
#9
Nguyen Ngoc Cuong, Vu Dang Luu, Tran Anh Tuan, Le Tuan Linh, Kieu Dinh Hung, Vo Truong Nhu Ngoc, Kulbhushan Sharma, Van Huy Pham, Dinh-Toi Chu
OBJECTIVES: Digital subtractional angiography (DSA) is the standard method for diagnosis, assessment and management of arteriovenous malformation in the brain. Conventional DSA (cDSA) is an invasive imaging modality that is often indicated before interventional treatments (embolization, open surgery, gamma knife). Here, we aimed to compare this technique with a non-invasive MR angiography (MRI DSA) for brain arteriovenous malformation (bAVM). PATIENTS AND METHODS: Fourteen patients with ruptured brain AVM underwent embolization treatment pre-operation...
March 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29582979/contemporary-endovascular-techniques-for-the-curative-treatment-of-cerebral-arteriovenous-malformations-and-review-of-neurointerventional-outcomes
#10
Pascal J Mosimann, René Chapot
INTRODUCTION: Since the first landmark randomized trials on unruptured bAVMs were published, there has been emerging concerns about the role of endovascular therapy. For bAVMs considered inoperable, embolization remains an option worth considering, especially in young patients presenting with a rupture. We aimed to review the curative potential of contemporary stand-alone embolization techniques enabling high occlusion rates and their respective short and long term safety profile. PATIENTS AND METHODS: We performed a PubMed search with the terms "curative embolization of brain arteriovenous malformations" and "endovascular cure of brain arteriovenous malformations" focusing on the last ten years (2008-2018) and compliant to the PRISMA reporting guidelines...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29582978/post-operative-management-and-follow-up-after-resection-of-arteriovenous-malformations
#11
Anna-Gila Karbe, Peter Vajkoczy
Arteriovenous malformation (AVM) of the brain is a rare condition with an estimated incidence rate of 2,05 cases per 100,000 person-years 1, primarily treated in specialized clinics. To prevent Arteriovenous malformations from bleeding, treatment via microsurgery, Stereotactic Radiosurgery or Endovascular Embolism can be undertaken. The success of surgically treated patients largely depends also on the proper postoperative management of the patient. This review will focus on the post-operative management after surgical treatment with specific emphasis on the unique condition in patients with an Arteriovenous Malformation, imaging routine post-operatively and follow-up after microsurgical resection of an AVM, presenting the current state in the literature...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29570006/use-of-the-apollo-detachable-tip-microcatheter-for-endovascular-embolization-of-arteriovenous-malformations-and-arteriovenous-fistulas
#12
Bruno C Flores, Alfred P See, Gregory M Weiner, Brian T Jankowitz, Andrew F Ducruet, Felipe C Albuquerque
OBJECTIVE Liquid embolic agents have revolutionized endovascular management of arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs). Nonetheless, since 2005, the US FDA has received more than 100 reports of microcatheter breakage or entrapment related to Onyx embolization, including 9 deaths. In 2014, the Apollo detachable-tip microcatheter became the first of its kind available in the US. Since then, few reports on its safety have been published. METHODS The authors conducted a retrospective review of endovascular cases by searching the patient databases at 2 tertiary cerebrovascular centers (Barrow Neurological Institute and University of Pittsburgh Medical Center)...
March 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29530384/awake-craniotomy-for-excision-of-arteriovenous-malformations-a-qualitative-comparison-study-with-stereotactic-radiosurgery
#13
David Yuen Chung Chan, Danny Tat Ming Chan, Cannon Xian Lun Zhu, Patricia Kwok Yee Kan, Amelia Yikjin Ng, Yi-Pin Sonia Hsieh, Jill Abrigo, Wai Sang Poon, George Kwok Chu Wong
Treatment of arteriovenous malformations (AVM) located at the eloquent area has been a challenge. Awake brain mapping allows identification of a non-eloquent gyrus for intervention and can potentially facilitate resection with preservation of functions. An alternative treatment option is stereotactic radiosurgery (SRS). The objective of this study was to perform a qualitative comparison of the treatment outcome of awake AVM excision versus SRS. We conducted a 13-year retrospective review of AVM excision under awake craniotomy performed at Prince of Wales Hospital, Hong Kong, from 2003 to 2016...
March 9, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29501883/positive-pharmacologic-provocative-testing-with-methohexital-during-cerebral-arteriovenous-malformation-embolization
#14
Orhan Bican, Charles Cho, Leslie Lee, Viet Nguyen, Scheherazade Le, Jeremy Heit, Jaime Lopez
A middle-aged patient underwent staged endovascular embolization of a Spetzler-Martin grade V right parietal arteriovenous malformation(AVM).In the fifth endovascular embolization, after methohexital 10 mg injection into a right posterior choroidal artery feeding the AVM nidus, there was an immediate change in the electroencephalogram (EEG) with simultaneous loss of motor evoked potentials (MEPs) in the bilateral upper and lower extremities and a delayed change in somatosensory evoked potential responses (SSEPs)...
February 25, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29483005/clinical-presentation-and-treatment-paradigms-of-brain-arteriovenous-malformations-in-patients-with-hereditary-hemorrhagic-telangiectasia
#15
Nicholas T Gamboa, Evan J Joyce, Ilyas Eli, Min S Park, Philipp Taussky, Richard H Schmidt, Jamie McDonald, Kevin J Whitehead, M Yashar S Kalani
Hereditary hemorrhagic telangiectasia (HHT) is characterized by recurrent spontaneous epistaxis, mucocutaneous telangiectases, and multisystem arteriovenous malformations (AVMs). Brain AVMs typically present at birth and are identified in approximately 10-20% of patients with HHT. A retrospective review was undertaken of all HHT patients with known single or multiple brain AVMs treated at our institution. Thirty-nine patients with brain AVM(s) were diagnosed with HHT. Most patients presented with at least one Curaçao criterion...
May 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29455411/completion-of-gamma-knife-radiosurgery-for-avm-treatment-after-unplanned-interruption-technical-note
#16
Hari S Raman, Lakshmi Santanam, Ananth K Vellimana, Robert E Drzymala, Christina I Tsien, Gregory J Zipfel
BACKGROUND AND IMPORTANCE: Gamma Knife radiosurgery is an established technique for non-urgent treatment of various intracranial pathologies. Intra-procedural dislodgement of the stereotactic frame is an uncommon occurrence that could lead to abortion of ongoing treatment and necessitate more invasive treatment strategies. CLINICAL PRESENTATION: In this case report, we describe a novel method for resumption of Gamma Knife treatment after an unplanned intra-procedural interruption...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29444560/cohort-studies-trials-and-tribulations-systematic-review-and-an-evidence-based-approach-to-avm-treatment
#17
Mary Simons, Michael K Morgan, Andrew S Davidson
INTRODUCTION: There is uncertainty as to the best management of arteriovenous malformations of the brain (bAVM). However, the Spetzler-Martin grade (SMG) has been validated as an effective determinant of surgical risks. We performed a systematic review for the best evidence regarding the management of bAVM for series that incorporate an analysis based upon SMG. EVIDENCE ACQUISITION: Medline, Embase, Scopus and Cochrane databases were searched for series between January 2000 and January 2018, with a minimum of 100 cases and that incorporated SMG stratification...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29371257/early-hemodynamic-response-assessment-of-stereotactic-radiosurgery-for-a-cerebral-arteriovenous-malformation-using-4d-flow-mri
#18
C Q Li, A Hsiao, J Hattangadi-Gluth, J Handwerker, N Farid
Brain AVMs treated with stereotactic radiosurgery typically demonstrate a minimum latency period of 1-3 years between treatment and nidus obliteration. Assessment of treatment response is usually limited to evaluation of AVM nidus structural changes using conventional MR imaging and MRA techniques. This report describes the use of 4D Flow MRI to also measure radiation-induced hemodynamic changes in a Spetzler-Martin grade III AVM, which were detectable as early as 6 months after treatment.
April 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29368047/the-impact-of-ntms-mapping-on-treatment-of-brain-avms
#19
Sebastian Ille, Thomas Picht, Ehab Shiban, Bernhard Meyer, Peter Vajkoczy, Sandro M Krieg
BACKGROUND: The treatment of brain arteriovenous malformations (BAVMs) is still contrarily discussed. Despite the debatable results of the ARUBA trial, most BAVMs still require treatment depending on the Spetzler-Martin (SM) grading. Since size is measurable and venous drainage is visible, the determination of eloquence is comparably crucial but not fully objective. The present bicentric cohort study aims to examine the influence of preoperative navigated transcranial magnetic stimulation (nTMS) motor and language mapping data on decision-making for or against surgical treatment of BAVMs...
March 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29281075/transvenous-curative-embolization-of-cerebral-arteriovenous-malformations-a-prospective-cohort-study
#20
George A C Mendes, M Yashar S Kalani, Christina Iosif, Adson F Lucena, Rui Carvalho, Suzana Saleme, Charbel Mounayer
BACKGROUND: Curative transvenous embolization is an emerging strategy for treatment of cerebral arteriovenous malformations (AVMs). OBJECTIVE: To assess contemporary outcomes of transvenous embolization as a stand-alone therapy for cerebral AVMs. METHODS: We prospectively followed 40 patients with 41 AVMs who underwent transvenous endovascular therapy between January 2008 and January 2015. Patient demographics, AVM characteristics, endovascular techniques used, angiographic results, clinical outcomes, and complications were assessed independently...
December 21, 2017: Neurosurgery
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