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https://www.readbyqxmd.com/read/29040909/treatment-with-fenofibrate-plus-a-low-dose-of-benznidazole-attenuates-cardiac-dysfunction-in-experimental-chagas-disease
#1
Ágata C Cevey, Gerardo A Mirkin, Martín Donato, María J Rada, Federico N Penas, Ricardo J Gelpi, Nora B Goren
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution of Chagas disease. Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation. In this study we investigated whether a PPAR-α agonist, Fenofibrate, improves cardiac function and inflammatory parameters in a murine model of T. cruzi infection. BALB/c mice were sequentially infected with two T...
October 7, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29040905/bilateral-methachronous-testicular-germ-cell-tumor-and-testicular-microlithiasis-in-a-child-genetic-analysis-and-insights-a-case-report
#2
N Boudaoud, G Loron, M Pons, E Landais, S Kozal, M Doco-Fenzy, M L Poli-Merol
OBJECTIVES: To report our experience with a case of a child with bilateral testicular micro-lithiasis (TML) who developed bilateral metachronous testicular germ cell tumor (TGCT) and determine the most appropriate follow-up and care management in children with testicular micro calcifications in regards to the theoretical risk of testicular cancer. CASE REPORT: A 12 year-old boy was diagnosed with TGCT and TML. Ten years after complete remission, he presented with a recurrence on the contralateral testis...
October 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29040783/patient-exposure-from-nuclear-medicine-in-france-national-follow-up-and-influence-of-the-technology-through-diagnostic-reference-levels-data-analysis
#3
Patrice Roch, David Celier, Cécile Dessaud, Cécile Etard
The Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest assessment from up-to-date diagnostic reference levels (DRL) national data in nuclear medicine (NM). NM departments annually send data to IRSN to estimate the representativeness of current DRLs. Complementary analyses of the data have been performed to evaluate the influence of equipment evolution on practice and patient radiation exposure. Based on data from almost 90% of the French NM departments, some DRL update are proposed...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040764/rif1-promotes-a-repressive-chromatin-state-to-safeguard-against-endogenous-retrovirus-activation
#4
Pishun Li, Li Wang, Brian D Bennett, Jiajia Wang, Jialun Li, Yufeng Qin, Motoki Takaku, Paul A Wade, Jiemin Wong, Guang Hu
Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their repression are not fully understood. To systematically study ERV repression, we carried out an RNAi screen in mouse embryonic stem cells (ESCs) and identified a list of novel regulators. Among them, Rif1 displays the strongest effect...
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040754/development-of-unique-cytotoxic-chimeric-antigen-receptors-based-on-human-scfv-targeting-b7h6
#5
Casey K Hua, Albert T Gacerez, Charles L Sentman, Margaret E Ackerman
As a stress-inducible natural killer (NK) cell ligand, B7H6 plays a role in innate tumor immunosurveillance and is a fairly tumor selective marker expressed on a variety of solid and hematologic cancer cells. Here, we describe the isolation and characterization of a new family of single chain fragment variable (scFv) molecules targeting the human B7H6 ligand. Through directed evolution of a yeast surface displayed non-immune human-derived scFv library, eight candidates comprising a single family of clones differing by up to four amino acid mutations and exhibiting nM avidities for soluble B7H6-Ig were isolated...
October 11, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29040752/expansion-of-the-dehydrin-gene-family-in-the-pinaceae-is-associated-with-considerable-structural-diversity-and-drought-responsive-expression
#6
Juliana Stival Sena, Isabelle Giguère, Philippe Rigault, Jean Bousquet, John Mackay
Temperatures are expected to increase over the next century in all terrestrial biomes and particularly in boreal forests, where drought-induced mortality has been predicted to rise. Genomics research is helping to develop hypotheses regarding the molecular basis of drought tolerance and recent work proposed that the osmo-protecting dehydrin proteins have undergone a clade-specific expansion in the Pinaceae, a major group of conifer trees. The objectives of this study were to identify all of the putative members of the gene family, trace their evolutionary origin, examine their structural diversity and test for drought-responsive expression...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29040713/human-argonaute3-has-slicer-activity
#7
Mi Seul Park, Hong-Duc Phan, Florian Busch, Samantha H Hinckley, James A Brackbill, Vicki H Wysocki, Kotaro Nakanishi
Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activity. The others (AGO1, AGO3 and AGO4) have been thought to assemble with microRNAs to form slicer-independent effector complexes that bind target mRNAs and silence gene expression through translational repression and deadenylation but not cleavage. Here, we report that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs, whereas AGO3 loaded with let-7a, miR-19b or miR-16 does not, indicating that AGO3 has slicer activity but that this activity depends on the guide RNA...
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040629/elongation-factor-1%C3%AE-accurately-reconstructs-relationships-amongst-psyllid-families-hemiptera-psylloidea-with-possible-diagnostic-implications
#8
Francesco Martoni, Simon R Bulman, Andrew Pitman, Karen F Armstrong
The superfamily Psylloidea (Hemiptera: Sternorrhyncha) lacks a robust multigene phylogeny. This impedes our understanding of the evolution of this group of insects and, consequently, an accurate identification of individuals, of their plant host associations, and their roles as vectors of economically important plant pathogens. The conserved nuclear gene elongation factor-1 alpha (EF-1α) has been valuable as a higher-level phylogenetic marker in insects and it has also been widely used to investigate the evolution of intron/exon structure...
October 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040588/glyphosate-resistance-and-epsps-gene-duplication-convergent-evolution-in-multiple-plant-species
#9
Eric L Patterson, Dean J Pettinga, Karl Ravet, Paul Neve, Todd A Gaines
One of the increasingly widespread mechanisms of resistance to the herbicide glyphosate is copy number variation (CNV) of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene. EPSPS gene duplication has been reported in eight weed species, ranging from 3-5 extra copies to more than 150 extra copies. In the case of Palmer amaranth (Amaranthus palmeri), a section of >300 kb containing EPSPS and many other genes has been replicated and inserted at new loci throughout the genome, resulting in significant increase in total genome size...
October 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29040484/esophagocardioplasty-vagotomy-antrectomy-and-roux-en-y-gastrojejunostomy-indication-in-cases-with-severe-esophageal-motor-disfunction
#10
I Braghetto, O Korn, A Csendes, J C Frias
Almost 10% of patients with Crest syndrome associated with severe gastroesophageal reflux and 5-10% of patients with failed cardiomyotomy for achalasia present with cardial or distal esophageal organic stricture. Some of these cases are poor risk patients for surgery and therefore the surgeon must offer a safe procedure with low morbimortality, keeping in mind the pathophysiological motor pattern of these patients.In order to treat the stricture to improve the esophageal transit we treated patients with esophagocardioplasty associated with vagotomy-antrectomy and Roux-en-Y gastrojejunostomy, thereby avoiding the potential acid or biliary reflux in poor risk patients in whom esophagectomy would be a very deleterious procedure...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040409/towards-dynamic-genome-scale-models
#11
David Gilbert, Monika Heiner, Yasoda Jayaweera, Christian Rohr
The analysis of the dynamic behaviour of genome-scale models of metabolism (GEMs) currently presents considerable challenges because of the difficulties of simulating such large and complex networks. Bacterial GEMs can comprise about 5000 reactions and metabolites, and encode a huge variety of growth conditions; such models cannot be used without sophisticated tool support. This article is intended to aid modellers, both specialist and non-specialist in computerized methods, to identify and apply a suitable combination of tools for the dynamic behaviour analysis of large-scale metabolic designs...
October 13, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29040399/toward-completion-of-the-earth-s-proteome-an-update-a-decade-later
#12
Pablo Mier, Miguel A Andrade-Navarro
Protein databases are steadily growing driven by the spread of new more efficient sequencing techniques. This growth is dominated by an increase in redundancy (homologous proteins with various degrees of sequence similarity) and by the incapability to process and curate sequence entries as fast as they are created. To understand these trends and aid bioinformatic resources that might be compromised by the increasing size of the protein sequence databases, we have created a less-redundant protein data set. In parallel, we analyzed the evolution of protein sequence databases in terms of size and redundancy...
October 12, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29040393/extending-the-scope-of-darwin-s-abominable-mystery-integrative-approaches-to-understanding-angiosperm-origins-and-species-richness
#13
Ofir Katz
Background and aims: Angiosperms are the most species-rich group of land plants, but their origins and fast and intense diversification still require an explanation. Scope: Extending research scopes can broaden theoretical frameworks and lines of evidence that can lead to solving this 'abominable mystery'. Solutions lie in understanding evolutionary trends across taxa and throughout the Phanerozoic, and integration between hypotheses and ideas that are derived from multiple disciplines...
October 10, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29040388/rna-structure-interactions-and-ribonucleoprotein-processes-of-the-influenza-a-virus
#14
Wayne K Dawson, Michal Lazniewski, Dariusz Plewczynski
In one more years, we will 'celebrate' an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is known of the expressed proteins and the protein products generated from alternative splicing, and on the role of base pairing in RNA structure. We highlight the main events associated with viral entry into the cell, the transcription and replication process, an export of the viral genetic material from the nucleus and the final release of the virus...
October 10, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29040379/contrasting-evolutionary-processes-during-quaternary-climatic-changes-and-historical-orogenies-a-case-study-of-the-japanese-endemic-primroses-primula-sect-reinii
#15
Masaya Yamamoto, Masato Ohtani, Kaoruko Kurata, Hiroaki Setoguchi
Background and Aims: Recent biogeographic studies have illustrated that Quaternary climatic changes and historical orogenies have driven the development of high levels of biodiversity. In this context, phylogenetic niche conservatism may play a role as a major precursor of allopatric speciation. However, the effects of niche evolution on the diversification patterns of plant species under rapid habitat changes are still unknown. Here, Primula section Reinii, one of the few primroses endemic to the Japanese Archipelago, was investigated...
October 13, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29040370/long-term-safety-of-textured-and-smooth-breast-implants
#16
M Bradley Calobrace, Michael R Schwartz, Kamakshi R Zeidler, Troy A Pittman, Robert Cohen, W Grant Stevens
In this review, the authors provide a 20-year review and comparison of implant options and describe the evolution of breast implant surface textures; compare available implant surfaces; present long-term safety data from the 10-year US-based Core clinical studies; list the key benefits and risks associated with smooth and textured implants; and provide perspectives on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The authors explore the key benefits and risks associated with all available devices so that optimal and safe patient outcomes can be achieved...
September 28, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040151/sex-differences-in-vascular-reactivity-to-angiotensin-ii-during-the-evolution-of-myocardial-infarction
#17
Flores-Monroy Jazmín, Ramirez-Hernández Diana, Samano-Hernández Citali, Lezama-Martínez Diego, Sampieri-Cabrera Raul, Martínez-Aguilar Luisa
The influence of sex on the vascular response during the progression of myocardial infarction (MI) has not been extensively studied. In this work, we analyzed the differences of the vasoconstriction-induced by angiotensin II (Ang II) in the absence and presence of valsartan (200 nM) on the aortic rings of male and female Wistar rats at 2, 4, 24, and 48 h and 1, 2, 3, and 4 weeks after induction of MI. In the aortic rings of males an increase was observed in the contractile response that lasts up to 4 weeks; on females, this effect is diminished since 48 h until reaching sham group values at 2 weeks of coronary occlusion...
September 29, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29040036/septic-thrombosis-of-cavernous-sinus-extended-to-the-ipsilateral-internal-jugular-vein-and-transversal-sinus-with-favorable-outcome-clinical-and-radiological-features-of-a-lemierre-syndrome
#18
Arnaud Martel
An 86-year-old patient was hospitalized for fever and left acute orbital syndrome (red eye with moderate visual impairment, chemosis, ophthalmoplegia without proptosis, or any fundus involvement). CT scan showed superior ophthalmic vein and cavernous sinus enlargement complicating ipsilateral sphenoidal sinusitis. Magnetic resonance imaging (MRI) demonstrated the left cavernous sinus thrombosis extended to the ipsilateral jugular vein and transversal sinus (Lemierre syndrome). Intravenous broad-spectrum antibiotics and curative anticoagulation were prescribed...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29039914/rapid-adsorption-enables-interface-engineering-of-pdmnco-alloy-nitrogen-doped-carbon-as-highly-efficient-electrocatalysts-for-hydrogen-evolution-reaction
#19
Ruirui Zhang, Zhongti Sun, Ruilu Feng, Zhiyu Lin, Haizhen Liu, Mengsi Li, Yang Yang, Ruohong Shi, Wenhua Zhang, Qianwang Chen
The catalytic performance of Pd-based catalysts has long been hindered by surface contamination, particle agglomeration and lack of rational structural design. Here we report a simple adsorption method for rapid synthesis (about 90 seconds) of structure optimized Pd alloy supported on nitrogen doped carbon without the use of surfactants or extra reducing agents. The material shows much lower overpotential than 30 wt% Pd/C and 40 wt% Pt/C catalysts while exhibiting excellent durability (80 hours). Moreover, unveiled by the density-functional theory calculation results, the underlying reason for the outstanding performance is that the PdMnCo alloy/pyridinic nitrogen doped carbon interfaces weaken the hydrogen adsorption energy on the catalyst and thus optimize the Gibbs free-energy of the intermediate state (ΔGH*), leading to a remarkable electrocatalytic activity...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29036916/recent-progresses-and-development-of-advanced-atomic-layer-deposition-towards-high-performance-li-ion-batteries
#20
REVIEW
Wei Lu, Longwei Liang, Xuan Sun, Xiaofei Sun, Chen Wu, Linrui Hou, Jinfeng Sun, Changzhou Yuan
Electrode materials and electrolytes play a vital role in device-level performance of rechargeable Li-ion batteries (LIBs). However, electrode structure/component degeneration and electrode-electrolyte sur-/interface evolution are identified as the most crucial obstacles in practical applications. Thanks to its congenital advantages, atomic layer deposition (ALD) methodology has attracted enormous attention in advanced LIBs. This review mainly focuses upon the up-to-date progress and development of the ALD in high-performance LIBs...
October 14, 2017: Nanomaterials
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