keyword
https://read.qxmd.com/read/38498082/design-synthesis-and-biological-evaluation-of-mnk-protacs
#1
JOURNAL ARTICLE
Xue Sun, Qingyun Wu, Hong Bu, Yifeng Pei, Dezhong Guan, Shi Guo, Jinpei Zhou, Huibin Zhang
Mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) can regulate cellular mRNA translation by controlling the phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E), which plays an important role in tumor initiation, development, and metastasis. Although small-molecule MNK inhibitors have made significant breakthroughs in the treatment of various malignancies, their clinical application can be limited by drug resistance, target selectivity and other factors. The strategy of MNK-PROTACs which selectively degrades MNK kinases provides a new approach for developing small-molecule drugs for related diseases...
March 18, 2024: Molecular Diversity
https://read.qxmd.com/read/38498021/tanzania-s-and-germany-s-digital-health-strategies-and-their-consistency-with-the-world-health-organization-s-global-strategy-on-digital-health-2020-2025-comparative-policy-analysis
#2
JOURNAL ARTICLE
Felix Holl, Jennifer Kircher, Attila J Hertelendy, Felix Sukums, Walter Swoboda
BACKGROUND: In recent years, the fast-paced adoption of digital health (DH) technologies has transformed health care delivery. However, this rapid evolution has also led to challenges such as uncoordinated development and information silos, impeding effective health care integration. Recognizing these challenges, nations have developed digital health strategies (DHSs), aligning with their national health priorities and guidance from global frameworks. The World Health Organization (WHO)'s Global Strategy on Digital Health 2020-2025 (GSDH) guides national DHSs...
March 18, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38497977/biodegradable-mg-mo-2-c-mxene-air-batteries-for-transient-energy-storage
#3
JOURNAL ARTICLE
Shunsuke Yamada
Primary batteries are the fundamental power sources in small electronic gadgets and bio/ecoresorbable batteries. They are fabricated from benign and biodegradable materials and are of interest in environmental sensing and implants because of their low toxicity toward the environment and human body during decomposition. However, current bio/ecoresorbable batteries suffer from low operating voltages and output powers because of the occurrence of undesired hydrogen evolution reactions (HERs) at cathodes. Herein, Mo2 C MXene was used as a cathode to achieve high operating voltage and areal power...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38497947/cyanuric-acid-assisted-synthesis-of-hierarchical-amorphous-carbon-nitride-assembled-by-ultrathin-oxygen-doped-nanosheets-for-excellent-photocatalytic-hydrogen-generation
#4
JOURNAL ARTICLE
Lin Lei, Huiqing Fan, Yuxin Jia, Li Lv, Jinwei Miao, Weijia Wang
Amorphous carbon nitride with typical short-range order arrangement as an effective photocatalyst is worth exploring but remains a great challenge because its disordered structure induces severe recombination of photogenerated charge carriers. Herein, for the first time, we demonstrate that a hierarchical amorphous carbon nitride (HACN) with structural oxygen incorporation can be synthesized via a cyanuric acid-assisted melem hydrothermal process, accompanied by freeze-drying and pyrolysis. The complex composed of melem and cyanuric acid exhibiting a unique 3D self-supporting skeleton and significant phase transformation is responsible for the formation of an interconnected hierarchical framework and amorphous structure for HACN...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38497843/ni-and-co-active-site-transition-and-competition-in-fluorine-doped-nico-oh-2-ldh-electrocatalysts-for-oxygen-evolution-reaction
#5
JOURNAL ARTICLE
Mao-Jun Pei, Yan-Kang Shuai, Xiang Gao, Jia-Cheng Chen, Yao Liu, Wei Yan, Jiujun Zhang
The oxygen evolution reaction (OER) performance of NiCo LDH electrocatalysts can be improved through fluorine doping. The roles of Ni and Co active sites in such catalysts remain ambiguous and controversial. In addressing the issue, this study draws upon the molecular orbital theory and proposes the active center competitive mechanism between Ni and Co. The doped F-atoms can directly impact the valence state of metal atoms or exert an indirect influence through the dehydrogenation, thereby modulating the active center...
March 18, 2024: Small
https://read.qxmd.com/read/38497664/isolation-of-a-recombinant-simian-adenovirus-encoding-the-human-adenovirus-g52-hexon-suggests-a-simian-origin-for-human-adenovirus-g52
#6
JOURNAL ARTICLE
Amanda N Pinski, Tianyu Gan, Shih-Ching Lin, Lindsay Droit, Michael Diamond, Dan H Barouch, David Wang
Human adenoviruses (HAdVs) are causative agents of morbidity and mortality throughout the world. These double-stranded DNA viruses are phylogenetically classified into seven different species (A-G). HAdV-G52, originally isolated in 2008 from a patient presenting with gastroenteritis, is the sole human-derived member of species G. Phylogenetic analysis previously suggested that HAdV-G52 may have a simian origin, indicating a potential zoonotic spillover into humans. However, evidence of HAdV-G52 in either human or simian populations has not been reported since...
March 18, 2024: Journal of Virology
https://read.qxmd.com/read/38497640/combining-crispr-cas9-and-natural-excision-for-the-precise-and-complete-removal-of-mobile-genetic-elements-in-bacteria
#7
JOURNAL ARTICLE
Pengxia Wang, Xiaofei Du, Yi Zhao, Weiquan Wang, Tongxuan Cai, Kaihao Tang, Xiaoxue Wang
Horizontal gene transfer, facilitated by mobile genetic elements (MGEs), is an adaptive evolutionary process that contributes to the evolution of bacterial populations and infectious diseases. A variety of MGEs not only can integrate into the bacterial genome but also can survive or even replicate like plasmids in the cytoplasm, thus requiring precise and complete removal for studying their strategies in benefiting host cells. Existing methods for MGE removal, such as homologous recombination-based deletion and excisionase-based methods, have limitations in effectively eliminating certain MGEs...
March 18, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38497586/chromosome-level-reference-genome-and-resequencing-of-322-accessions-reveal-evolution-genomic-imprint-and-key-agronomic-traits-in-adzuki-bean
#8
JOURNAL ARTICLE
Liwei Chu, Kai Yang, Chunhai Chen, Bo Zhao, Yanan Hou, Wanqiu Wang, Pu Zhao, Kaili Wang, Binhu Wang, Ying Xiao, Yongqiang Li, Yisong Li, Qijian Song, Biao Liu, Ruoxi Fan, Abhishek Bohra, Jianping Yu, Eva C Sonnenschein, Rajeev K Varshney, Zhixi Tian, Jianbo Jian, Ping Wan
Adzuki bean (Vigna angularis) is an important legume crop cultivated in over 30 countries worldwide. We developed a high-quality chromosome-level reference genome of adzuki bean cultivar Jingnong6 by combining PacBio Sequel long-read sequencing with short-read and Hi-C technologies. The assembled genome covers 97.8% of the adzuki bean genome with a contig N50 of approximately 16 Mb and a total of 32 738 protein-coding genes. We also generated a comprehensive genome variation map of adzuki bean by whole-genome resequencing (WGRS) of 322 diverse adzuki beans accessions including both wild and cultivated...
March 18, 2024: Plant Biotechnology Journal
https://read.qxmd.com/read/38497531/caspase-1-activates-gasdermin-a-in-non-mammals
#9
JOURNAL ARTICLE
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA. Here, we perform a comprehensive evolutionary analysis of the gasdermin family. A gene duplication of GSDMA in the common ancestor of caecilian amphibians, reptiles, and birds gave rise to GSDMA-D in mammals...
March 18, 2024: ELife
https://read.qxmd.com/read/38497522/evolution-of-volatile-compounds-of-baked-dried-tofu-during-infrared-baking-process-and-their-correlation-with-relevant-physicochemical-properties
#10
JOURNAL ARTICLE
Wenqing Chen, Haile Ma, Qunhui Jiang, Chen Shen
BACKGROUND: Energy-saving and low-carbon baking processes, as well as the need to determine the flavor-forming mechanisms of baked dried tofu, were becoming increasingly necessary. The application of emerging catalytic infrared radiation (CIR) technology in baking of dried tofu is considered of high interest due to the low energy consumption and high baking efficiency compared to traditional baking methods. Hence, this study aimed to investigate the evolution of aroma compounds in baked dried tofu during CIR baking process and reveal relevant relationships between physical qualities, potential flavor precursors and key volatile compounds...
March 18, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38497503/dual-function-of-naphthalenediimide-supramolecular-photocatalyst-with-giant-internal-electric-field-for-efficient-hydrogen-and-oxygen-evolution
#11
JOURNAL ARTICLE
Shicheng Xu, Siqi Chen, Yuxin Li, Qiong Gao, Xingjian Luo, Min Li, Lirong Ren, Peng Wang, Liping Liu, Jun Wang, Xianjie Chen, Qian Chen, Yongfa Zhu
Organic supramolecular photocatalysts have garnered widespread attention due to their adjustable structure and exceptional photocatalytic activity. Herein, a novel bis-dicarboxyphenyl-substituent naphthalenediimide self-assembly supramolecular photocatalyst (SA-NDI-BCOOH) with efficient dual-functional photocatalytic performance is successfully constructed. The large molecular dipole moment and short-range ordered stacking structure of SA-NDI-BCOOH synergistically create a giant internal electric field (IEF), resulting in a remarkable 6...
March 18, 2024: Small
https://read.qxmd.com/read/38497498/interfacial-electronic-interaction-in-amorphous-crystalline-ceo-x-sn-heterostructures-for-optimizing-co-2-to-formate-conversion
#12
JOURNAL ARTICLE
Ying Zhu, Xiang Sun, Rong Zhang, Xiaochen Feng, Ying Zhu
Formate, a crucial chemical raw material, holds significant promise for industrial applications in the context of CO2 electroreduction reaction (CO2 RR). Despite its potential, challenges, such as poor selectivity and low formation rate at high current densities persist, primarily due to the competing hydrogen evolution reaction (HER) and high energy barriers associated with *OCHO intermediate generation. Herein, one-step chemical co-reduction strategy is employed to construct an amorphous-crystalline CeOx -Sn heterostructure, demonstrating remarkable catalytic performance in converting CO2 to formate...
March 18, 2024: Small
https://read.qxmd.com/read/38497461/american-association-for-anatomy-recommendations-for-the-management-of-legacy-anatomical-collections
#13
REVIEW
Jon Cornwall, Thomas H Champney, Carlina de la Cova, Dominic Hall, Sabine Hildebrandt, Jason C Mussell, Andreas Winkelmann, Valerie B DeLeon
Collections of human remains in scientific and private institutions have a long tradition, though throughout history there has often been variable regard for the respect and dignity that these tissues demand. Recent public scandals around the use of human remains, coupled with an increasing community awareness around accountability in such instances, forces scholars to confront the ethical and moral concerns associated with these collections. This includes specific focus on the acquisition, storage, use, and disposition of these remains, which were often collected with no consent and with little knowledge, or concern, about the individual or their respective culture and practices surrounding death and postmortem treatment...
March 18, 2024: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://read.qxmd.com/read/38497446/spanish-french-leech-trade-and-its-consequences-from-the-increase-in-medical-demand-to-resource-depletion-and-technical-innovation
#14
JOURNAL ARTICLE
Damián Copena, María Gómez-Martín
This article studies the impact caused by the success and dissemination of Broussais' theories on the use of leeches as a medical supply on Spanish-French trade relations, as well as its consequences for the Spanish market between 1821 and the 1860s. Analysing the documents produced by the different public administrations, together with newspaper and archival sources in both Spain and France and the literature and legislation of that period, allows us to understand the evolution of this trade and the heavy impact it had on the autochthonous population of this animal resource...
March 18, 2024: Medical History
https://read.qxmd.com/read/38497317/global-level-of-methylation-in-the-sea-lamprey-jawless-vertebrate-genome-is-intermediate-between-invertebrate-and-jawed-vertebrate-genomes
#15
JOURNAL ARTICLE
Zhao Zhang, Gangbiao Liu, Zhan Zhou, Zhixi Su, Xun Gu
In eukaryotes, cytosine methylation is a primary heritable epigenetic modification of the genome that regulates many cellular processes. In invertebrate, methylated cytosine generally located on specific genomic elements (e.g., gene bodies and silenced repetitive elements) to show a "mosaic" pattern. While in jawed vertebrate (teleost and tetrapod), highly methylated cytosine located genome-wide but only absence at regulatory regions (e.g., promoter and enhancer). Many studies imply that the evolution of DNA methylation reprogramming may have helped the transition from invertebrates to jawed vertebrates, but the detail remains largely elusive...
March 18, 2024: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://read.qxmd.com/read/38497269/how-infection-triggered-pathobionts-influence-virulence-evolution
#16
JOURNAL ARTICLE
Mathias Franz, Roland R Regoes, Jens Rolff
Host-pathogen interactions can be influenced by the host microbiota, as the microbiota can facilitate or prevent pathogen infections. In addition, members of the microbiota can become virulent. Such pathobionts can cause co-infections when a pathogen infection alters the host immune system and triggers dysbiosis. Here we performed a theoretical investigation of how pathobiont co-infections affect the evolution of pathogen virulence. We explored the possibility that the likelihood of pathobiont co-infection depends on the evolving virulence of the pathogen...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497268/tethering-of-soluble-immune-effectors-to-mucin-and-chitin-reflects-a-convergent-and-dynamic-role-in-gut-immunity
#17
REVIEW
L J Dishaw, G W Litman, A Liberti
The immune system employs soluble effectors to shape luminal spaces. Antibodies are soluble molecules that effect immunological responses, including neutralization, opsonization, antibody-dependent cytotoxicity and complement activation. These molecules are comprised of immunoglobulin (Ig) domains. The N-terminal Ig domains recognize antigen, and the C-terminal domains facilitate their elimination through phagocytosis (opsonization). A less-recognized function mediated by the C-terminal Ig domains of the IgG class of antibodies (Fc region) involves the formation of multiple low-affinity bonds with the mucus matrix...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497262/evolutionary-immunology-to-explore-original-antiviral-strategies
#18
REVIEW
Jean-Luc Imler, Hua Cai, Carine Meignin, Nelson Martins
Over the past 25 years, the field of evolutionary developmental biology (evo-devo) has used genomics and genetics to gain insight on the developmental mechanisms underlying the evolution of morphological diversity of animals. Evo-devo exploits the key insight that conserved toolkits of development (e.g. Hox genes) are used in animals to produce genetic novelties that provide adaptation to a new environment. Like development, immunity is forged by interactions with the environment, namely the microbial world...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497259/when-the-microbiome-shapes-the-host-immune-evolution-implications-for-infectious-disease
#19
REVIEW
Mark A Hanson
The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests hosts can selectively activate innate immunity upon pathogenic infection, but not mutualist colonization. Another idea posits that hosts can selectively attack pathogens, but not mutualists. Here I review evolutionary principles of microbe recognition and immune activation, and reflect on newly observed immune effector-microbe specificity perhaps supporting the latter idea...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497257/the-role-of-animal-hosts-in-shaping-gut-microbiome-variation
#20
REVIEW
Elisa Maritan, Andrea Quagliariello, Enric Frago, Tomaso Patarnello, Maria Elena Martino
Millions of years of co-evolution between animals and their associated microbial communities have shaped and diversified the nature of their relationship. Studies continue to reveal new layers of complexity in host-microbe interactions, the fate of which depends on a variety of different factors, ranging from neutral processes and environmental factors to local dynamics. Research is increasingly integrating ecosystem-based approaches, metagenomics and mathematical modelling to disentangle the individual contribution of ecological factors to microbiome evolution...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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