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https://www.readbyqxmd.com/read/28406396/sirt6-regulates-ras-related-protein-r-ras2-by-lysine-defatty-acylation
#1
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a member of the Ras family. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2. In mouse embryonic fibroblasts (MEFs), Sirt6 knockout (KO) increased R-Ras2 lysine fatty acylation...
April 13, 2017: ELife
https://www.readbyqxmd.com/read/28402488/evaluation-of-the-24-hour-recall-as-a-reference-instrument-for-calibrating-other-self-report-instruments-in-nutritional-cohort-studies-evidence-from-the-validation-studies-pooling-project
#2
Laurence S Freedman, John M Commins, Walter Willett, Lesley F Tinker, Donna Spiegelman, Donna Rhodes, Nancy Potischman, Marian L Neuhouser, Alanna J Moshfegh, Victor Kipnis, David J Baer, Lenore Arab, Ross L Prentice, Amy F Subar
Calibrating dietary self-report instruments is recommended as a way to adjust for measurement error when estimating diet-disease associations. Because biomarkers available for calibration are limited, most investigators use self-reports (e.g., 24-hour recalls (24HRs)) as the reference instrument. We evaluated the performance of 24HRs as reference instruments for calibrating food frequency questionnaires (FFQs), using data from the Validation Studies Pooling Project, comprising 5 large validation studies using recovery biomarkers...
April 10, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28387836/switching-to-second-line-art-in-relation-to-mortality-in-a-large-tanzanian-hiv-cohort
#3
Claudia Hawkins, Ellen Hertzmark, Donna Spiegelman, Aisa Muya, Nzovu Ulenga, Sehee Kim, Polyna Khudyakov, Beatrice Christian, David Sando, Eric Aris, Wafaie Fawzi
Objectives: In a large cohort of HIV-infected Tanzanians, we assessed: (i) rates of first-line treatment failure and switches to second-line ART; (ii) the effect of switching to second-line ART on death and loss to follow-up; and (iii) treatment outcomes on second-line ART by regimen. Methods: HIV-1-infected adults (≥15 years) initiated on first-line ART between November 2004 and September 2012, and who remained on initial therapy for at least 24 weeks before switching, were studied...
April 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28380374/mitochondrial-patch-clamp-of-beige-adipocytes-reveals-ucp1-positive-and-ucp1-negative-cells-both-exhibiting-futile-creatine-cycling
#4
Ambre M Bertholet, Lawrence Kazak, Edward T Chouchani, Marta G Bogaczyńska, Ishan Paranjpe, Gabrielle L Wainwright, Alexandre Bétourné, Shingo Kajimura, Bruce M Spiegelman, Yuriy Kirichok
Cold and other environmental factors induce "browning" of white fat depots-development of beige adipocytes with morphological and functional resemblance to brown fat. Similar to brown fat, beige adipocytes are assumed to express mitochondrial uncoupling protein 1 (UCP1) and are thermogenic due to the UCP1-mediated H(+) leak across the inner mitochondrial membrane. However, this assumption has never been tested directly. Herein we patch clamped the inner mitochondrial membrane of beige and brown fat to provide a direct comparison of their thermogenic H(+) leak (IH)...
April 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28379291/heterozygous-pink1-p-g411s-in-rapid-eye-movement-sleep-behaviour-disorder
#5
Ziv Gan-Or, Jennifer A Ruskey, Dan Spiegelman, Isabelle Arnulf, Yves Dauvilliers, Birgit Högl, Christelle Monaca-Charley, Ronald B Postuma, Jacques Y Montplaisir, Guy A Rouleau
No abstract text is available yet for this article.
March 29, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28338828/validity-of-a-dietary-questionnaire-assessed-by-comparison-with-multiple-weighed-dietary-records-or-24-hour-recalls
#6
Changzheng Yuan, Donna Spiegelman, Eric B Rimm, Bernard A Rosner, Meir J Stampfer, Junaidah B Barnett, Jorge E Chavarro, Amy F Subar, Laura K Sampson, Walter C Willett
The authors evaluated the validity of a 152-item semiquantitative food frequency questionnaire (SFFQ) by comparing it with two 7-day dietary records (7DDRs) or up to 4 automated self-administered 24-hour recalls (ASA24s) over a 1-year period in the women's Lifestyle Validation Study (2010-2012), conducted among subgroups of the Nurses' Health Studies. Intakes of energy and 44 nutrients were assessed using the 3 methods among 632 US women. Compared with the 7DDRs, SFFQ responses tended to underestimate sodium intake but overestimate intakes of energy, macronutrients, and several nutrients in fruits and vegetables, such as carotenoids...
April 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28291481/self-reported-visual-quality-of-life-after-combat-ocular-trauma
#7
Andrew McLaughlin, Marcus H Colyer, Denise S Ryan, Rose K Sia, Eric D Weichel, Andrew Spiegelman, S G Eaddy, Robert A Mazzoli, Kraig S Bower
OBJECTIVES: To describe the visual outlook and quality of life of service members after combat ocular trauma. METHODS: In a single-center, prospective observational study of service members sustaining ocular trauma, participants underwent a series of ocular examinations and noninvasive tests, including the National Eye Institute Visual Functioning Questionnaire (VFQ-25). RESULTS: Of the 165 enrolled participants, 137 completed the VFQ-25. The mean VFQ-25 composite score was 74...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28276201/rare-deleterious-variants-in-grhl3-are-associated-with-human-spina-bifida
#8
Philippe Lemay, Patrizia De Marco, Alexandre Emond, Dan Spiegelman, Alexandre Dionne-Laporte, Sandra Laurent, Elisa Merello, Andrea Accogli, Guy A Rouleau, Valeria Capra, Zoha Kibar
Neural tube defects (NTDs), including spina bifida, are among the most common birth defects caused by failure of neural tube closure during development. They have a complex etiology involving largely undetermined environmental and genetic factors. Previous studies in mouse models have implicated the transcription factor Grhl3 as an important factor in the pathogenesis of spina bifida. In the present study, we conducted a re-sequencing analysis of GRHL3 in a cohort of 233 familial and sporadic cases of spina bifida...
March 8, 2017: Human Mutation
https://www.readbyqxmd.com/read/28249003/the-prospective-impact-of-food-pricing-on-improving-dietary-consumption-a-systematic-review-and-meta-analysis
#9
Ashkan Afshin, José L Peñalvo, Liana Del Gobbo, Jose Silva, Melody Michaelson, Martin O'Flaherty, Simon Capewell, Donna Spiegelman, Goodarz Danaei, Dariush Mozaffarian
BACKGROUND: While food pricing is a promising strategy to improve diet, the prospective impact of food pricing on diet has not been systematically quantified. OBJECTIVE: To quantify the prospective effect of changes in food prices on dietary consumption. DESIGN: We systematically searched online databases for interventional or prospective observational studies of price change and diet; we also searched for studies evaluating adiposity as a secondary outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28236510/a-strategy-for-dual-inhibition-of-the-proteasome-and-fatty-acid-synthase-with-belactosin-c-orlistat-hybrids
#10
Mingzhao Zhu, Wayne D Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G Hull, Sung Wook Cho, Robyn D Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T Wilson, Ju Anne Yau, James T Moore, Caitlen B Walker, James C Sacchettini, Wenshe R Liu, Stephan A Sieber, Jeffrey W Smith, Daniel Romo
The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation and ultimately cellular apoptosis. Based on structural similarities, we hypothesized that hybrid molecules of belactosin C, a known proteasome inhibitor, and orlistat, a known inhibitor of the thioesterase domain of FAS, could inhibit both enzymes...
January 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28196865/s-palmitoylation-of-junctional-adhesion-molecule-c-regulates-its-tight-junction-localization-and-cell-migration
#11
Pornpun Aramsangtienchai, Nicole A Spiegelman, Ji Cao, Hening Lin
Junctional adhesion molecule C (JAM-C) is an immunoglobulin superfamily protein expressed in epithelial cells, endothelial cells, and leukocytes. JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell adhesion, cell polarity, spermatogenesis, and metastasis. Here, we show that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys-264 and Cys-265. We have identified DHHC7 as a JAM-C palmitoylating enzyme by screening all known palmitoyltransferases (DHHCs)...
March 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28158909/teneurin-transmembrane-protein-4-is-not-a-cause-for-essential-tremor-in-a-canadian-population
#12
Gabrielle Houle, Jean-François Schmouth, Claire S Leblond, Amirthagowri Ambalavanan, Dan Spiegelman, Sandra B Laurent, Cynthia V Bourassa, Michel Panisset, Sylvain Chouinard, Nicolas Dupré, Carles Vilariño-Güell, Alex Rajput, Patrick A Dion, Guy A Rouleau
INTRODUCTION: Mutations in teneurin transmembrane protein 4 were reported to be a risk factor for essential tremor, but the relevance of this across different population remains to be examined. The aim of this study was to determine the frequency and spectrum of variations in teneurin transmembrane protein 4 in a cohort of Canadian essential tremor cases. METHODS: The coding portion of teneurin transmembrane protein 4 was sequenced in 269 unrelated essential tremor cases and 288 matched control individuals using a targeted and high-throughput sequencing approach...
February 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28115667/vitamin-a-and-zinc-supplementation-among-pregnant-women-to-prevent-placental-malaria-a-randomized-double-blind-placebo-controlled-trial-in-tanzania
#13
Anne Marie Darling, Ferdinand M Mugusi, Analee J Etheredge, Nilupa S Gunaratna, Ajibola Ibraheem Abioye, Said Aboud, Christopher Duggan, Robert Mongi, Donna Spiegelman, Drucilla Roberts, Davidson H Hamer, Kevin C Kain, Wafaie W Fawzi
Vitamin A and zinc are important for immune function and may improve host defense against malaria and reduce the risk of adverse pregnancy outcomes. Our objective was to determine whether daily oral supplementation with either or both nutrients starting in the first trimester reduces the risk of placental malaria and adverse pregnancy outcomes. We undertook a randomized, double-blind placebo-controlled trial with a factorial design among 2,500 human immunodeficiency virus-negative primigravid or secundigravid pregnant women in their first trimester of pregnancy in Dar es Salaam, Tanzania...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28093263/-cross-sectional-stepped-wedge-designs-always-reduce-the-required-sample-size-when-there-is-no-time-effect
#14
LETTER
Xin Zhou, Xiaomei Liao, Donna Spiegelman
No abstract text is available yet for this article.
January 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28053189/function-of-cyclophilin1-as-a-long-distance-signal-molecule-in-the-phloem-of-tomato-plants
#15
Ziv Spiegelman, Sumita Omer, Ben N Mansfeld, Shmuel Wolf
Tomato (Solanum lycopersicum) diageotropica (dgt) mutants, containing a single mutation in the Cyclophilin1 (SlCyp1) gene, are auxin-insensitive, exhibiting a pleiotropic phenotype including lack of geotropism, abnormal xylem structure, lack of lateral roots (LRs), and elevated shoot-to-root ratio. SlCyp1 is a putative peptidyl-prolyl isomerase that can traffic from shoot to root, where it induces changes in auxin response, LR formation, and xylem development, suggesting it has a role as a long-distance signaling molecule...
February 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27974182/retraction-notice-to-activation-of-the-ppar-pgc-1%C3%AE-pathway-prevents-a-bioenergetic-deficit-and-effectively-improves-a-mitochondrial-myopathy-phenotype
#16
Tina Wenz, Francisca Diaz, Bruce M Spiegelman, Carlos T Moraes
No abstract text is available yet for this article.
December 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27923781/population-attributable-risk-of-modifiable-and-nonmodifiable-breast-cancer-risk-factors-in-postmenopausal-breast-cancer
#17
Rulla M Tamimi, Donna Spiegelman, Stephanie A Smith-Warner, Molin Wang, Mathew Pazaris, Walter C Willett, A Heather Eliassen, David J Hunter
We examined the proportions of multiple types of breast cancers in the population that were attributable to established risk factors, focusing on behaviors that are modifiable at menopause. We estimated the full and partial population attributable risk percentages (PAR%) by combining the relative risks and the observed prevalence rates of the risk factors of interest. A total of 8,421 cases of invasive breast cancer developed in postmenopausal women (n = 121,700) in the Nurses' Health Study from 1980-2010...
December 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27872756/prevalence-of-hypertension-and-its-associated-risk-factors-among-34-111-haart-na%C3%A3-ve-hiv-infected-adults-in-dar-es-salaam-tanzania
#18
Marina Njelekela, Alfa Muhihi, Akum Aveika, Donna Spiegelman, Claudia Hawkins, Catharina Armstrong, Enju Liu, James Okuma, Guerino Chalamila, Sylvia Kaaya, Ferdinand Mugusi, Wafaie Fawzi
Background. Elevated blood pressure has been reported among treatment naïve HIV-infected patients. We investigated prevalence of hypertension and its associated risk factors in a HAART naïve HIV-infected population in Dar es Salaam, Tanzania. Methods. A cross-sectional analysis was conducted among HAART naïve HIV-infected patients. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg. Overweight and obesity were defined as body mass index (BMI) between 25...
2016: International Journal of Hypertension
https://www.readbyqxmd.com/read/27871269/institutionalizing-postpartum-intrauterine-device-iud-services-in-sri-lanka-tanzania-and-nepal-study-protocol-for-a-cluster-randomized-stepped-wedge-trial
#19
David Canning, Iqbal H Shah, Erin Pearson, Elina Pradhan, Mahesh Karra, Leigh Senderowicz, Till Bärnighausen, Donna Spiegelman, Ana Langer
BACKGROUND: During the year following the birth of a child, 40% of women are estimated to have an unmet need for contraception. The copper IUD provides safe, effective, convenient, and long-term contraceptive protection that does not interfere with breastfeeding during the postpartum period. Postpartum IUD (PPIUD) insertion should be performed by a trained provider in the early postpartum period to reduce expulsion rates and complications, but these services are not widely available. The International Federation of Obstetricians and Gynecologists (FIGO) will implement an intervention that aims to institutionalize PPIUD training as a regular part of the OB/GYN training program and to integrate it as part of the standard practice at the time of delivery in intervention hospitals...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27861238/complementary-feeding-and-diarrhea-and-respiratory-infection-among-hiv-exposed-tanzanian-infants
#20
Pili Kamenju, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Rodrick R Kisenge, Roland Kupka, Said Aboud, Karim Manji, Christopher Duggan, Wafaie W Fawzi
OBJECTIVE: To examine the association between complementary feeding and risks of diarrhea and acute respiratory infection (ARI) among HIV-exposed infants aged 6-24 months. DESIGN: We prospectively used an Infant and Child Feeding Index (ICFI) to measure complementary feeding practices (breastfeeding status, food consistency, dietary diversity, food group frequency, and meal frequency). We determined the association of ICFI and each of its components with the risk of diarrhea and ARI...
March 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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