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https://www.readbyqxmd.com/read/28291481/self-reported-visual-quality-of-life-after-combat-ocular-trauma
#1
Andrew McLaughlin, Marcus H Colyer, Denise S Ryan, Rose K Sia, Eric D Weichel, Andrew Spiegelman, S G Eaddy, Robert A Mazzoli, Kraig S Bower
OBJECTIVES: To describe the visual outlook and quality of life of service members after combat ocular trauma. METHODS: In a single-center, prospective observational study of service members sustaining ocular trauma, participants underwent a series of ocular examinations and noninvasive tests, including the National Eye Institute Visual Functioning Questionnaire (VFQ-25). RESULTS: Of the 165 enrolled participants, 137 completed the VFQ-25. The mean VFQ-25 composite score was 74...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28276201/rare-deleterious-variants-in-grhl3-are-associated-with-human-spina-bifida
#2
Philippe Lemay, Patrizia De Marco, Alexandre Emond, Dan Spiegelman, Alexandre Dionne-Laporte, Sandra Laurent, Elisa Merello, Andrea Accogli, Guy A Rouleau, Valeria Capra, Zoha Kibar
Neural tube defects (NTDs), including spina bifida, are among the most common birth defects caused by failure of neural tube closure during development. They have a complex etiology involving largely undetermined environmental and genetic factors. Previous studies in mouse models have implicated the transcription factor Grhl3 as an important factor in the pathogenesis of spina bifida. In the present study, we conducted a re-sequencing analysis of GRHL3 in a cohort of 233 familial and sporadic cases of spina bifida...
March 8, 2017: Human Mutation
https://www.readbyqxmd.com/read/28249003/the-prospective-impact-of-food-pricing-on-improving-dietary-consumption-a-systematic-review-and-meta-analysis
#3
Ashkan Afshin, José L Peñalvo, Liana Del Gobbo, Jose Silva, Melody Michaelson, Martin O'Flaherty, Simon Capewell, Donna Spiegelman, Goodarz Danaei, Dariush Mozaffarian
BACKGROUND: While food pricing is a promising strategy to improve diet, the prospective impact of food pricing on diet has not been systematically quantified. OBJECTIVE: To quantify the prospective effect of changes in food prices on dietary consumption. DESIGN: We systematically searched online databases for interventional or prospective observational studies of price change and diet; we also searched for studies evaluating adiposity as a secondary outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28236510/a-strategy-for-dual-inhibition-of-the-proteasome-and-fatty-acid-synthase-with-belactosin-c-orlistat-hybrids
#4
Mingzhao Zhu, Wayne D Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G Hull, Sung Wook Cho, Robyn D Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T Wilson, Ju Anne Yau, James T Moore, Caitlen B Walker, James C Sacchettini, Wenshe R Liu, Stephan A Sieber, Jeffrey W Smith, Daniel Romo
The proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis. Perturbation of either enzymatic machine results in decreased proliferation and ultimately cellular apoptosis. Based on structural similarities, we hypothesized that hybrid molecules of belactosin C, a known proteasome inhibitor, and orlistat, a known inhibitor of the thioesterase domain of FAS, could inhibit both enzymes...
January 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28196865/s-palmitoylation-of-junctional-adhesion-molecule-c-regulates-its-tight-junction-localization-and-cell-migration
#5
Pornpun Aramsangtienchai, Nicole A Spiegelman, Ji Cao, Hening Lin
Junctional Adhesion Molecule C (JAM-C) is an immunoglobulin superfamily protein expressed in epithelial cells, endothelial cells, and leukocytes. JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell-adhesion, cell polarity, spermatogenesis and metastasis. Here, we show that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys264 and Cys265. We have identified DHHC7 as a JAM-C palmitoylating enzyme by screening all known palmitoyltransferases (PATs or DHHCs)...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28158909/teneurin-transmembrane-protein-4-is-not-a-cause-for-essential-tremor-in-a-canadian-population
#6
Gabrielle Houle, Jean-François Schmouth, Claire S Leblond, Amirthagowri Ambalavanan, Dan Spiegelman, Sandra B Laurent, Cynthia V Bourassa, Michel Panisset, Sylvain Chouinard, Nicolas Dupré, Carles Vilariño-Güell, Alex Rajput, Patrick A Dion, Guy A Rouleau
INTRODUCTION: Mutations in teneurin transmembrane protein 4 were reported to be a risk factor for essential tremor, but the relevance of this across different population remains to be examined. The aim of this study was to determine the frequency and spectrum of variations in teneurin transmembrane protein 4 in a cohort of Canadian essential tremor cases. METHODS: The coding portion of teneurin transmembrane protein 4 was sequenced in 269 unrelated essential tremor cases and 288 matched control individuals using a targeted and high-throughput sequencing approach...
February 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28115667/vitamin-a-and-zinc-supplementation-among-pregnant-women-to-prevent-placental-malaria-a-randomized-double-blind-placebo-controlled-trial-in-tanzania
#7
Anne Marie Darling, Ferdinand M Mugusi, Analee J Etheredge, Nilupa S Gunaratna, Ajibola Ibraheem Abioye, Said Aboud, Christopher Duggan, Robert Mongi, Donna Spiegelman, Drucilla Roberts, Davidson H Hamer, Kevin C Kain, Wafaie W Fawzi
Vitamin A and zinc are important for immune function and may improve host defense against malaria and reduce the risk of adverse pregnancy outcomes. Our objective was to determine whether daily oral supplementation with either or both nutrients starting in the first trimester reduces the risk of placental malaria and adverse pregnancy outcomes. We undertook a randomized, double-blind placebo-controlled trial with a factorial design among 2,500 human immunodeficiency virus-negative primigravid or secundigravid pregnant women in their first trimester of pregnancy in Dar es Salaam, Tanzania...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28093263/-cross-sectional-stepped-wedge-designs-always-reduce-the-required-sample-size-when-there-is-no-time-effect
#8
LETTER
Xin Zhou, Xiaomei Liao, Donna Spiegelman
No abstract text is available yet for this article.
January 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28053189/function-of-cyclophilin1-as-a-long-distance-signal-molecule-in-the-phloem-of-tomato-plants
#9
Ziv Spiegelman, Sumita Omer, Ben N Mansfeld, Shmuel Wolf
Tomato (Solanum lycopersicum) diageotropica (dgt) mutants, containing a single mutation in the Cyclophilin1 (SlCyp1) gene, are auxin-insensitive, exhibiting a pleiotropic phenotype including lack of geotropism, abnormal xylem structure, lack of lateral roots (LRs), and elevated shoot-to-root ratio. SlCyp1 is a putative peptidyl-prolyl isomerase that can traffic from shoot to root, where it induces changes in auxin response, LR formation, and xylem development, suggesting it has a role as a long-distance signaling molecule...
January 4, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27974182/retraction-notice-to-activation-of-the-ppar-pgc-1%C3%AE-pathway-prevents-a-bioenergetic-deficit-and-effectively-improves-a-mitochondrial-myopathy-phenotype
#10
Tina Wenz, Francisca Diaz, Bruce M Spiegelman, Carlos T Moraes
No abstract text is available yet for this article.
December 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27923781/population-attributable-risk-of-modifiable-and-nonmodifiable-breast-cancer-risk-factors-in-postmenopausal-breast-cancer
#11
Rulla M Tamimi, Donna Spiegelman, Stephanie A Smith-Warner, Molin Wang, Mathew Pazaris, Walter C Willett, A Heather Eliassen, David J Hunter
We examined the proportions of multiple types of breast cancers in the population that were attributable to established risk factors, focusing on behaviors that are modifiable at menopause. We estimated the full and partial population attributable risk percentages (PAR%) by combining the relative risks and the observed prevalence rates of the risk factors of interest. A total of 8,421 cases of invasive breast cancer developed in postmenopausal women (n = 121,700) in the Nurses' Health Study from 1980-2010...
December 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27872756/prevalence-of-hypertension-and-its-associated-risk-factors-among-34-111-haart-na%C3%A3-ve-hiv-infected-adults-in-dar-es-salaam-tanzania
#12
Marina Njelekela, Alfa Muhihi, Akum Aveika, Donna Spiegelman, Claudia Hawkins, Catharina Armstrong, Enju Liu, James Okuma, Guerino Chalamila, Sylvia Kaaya, Ferdinand Mugusi, Wafaie Fawzi
Background. Elevated blood pressure has been reported among treatment naïve HIV-infected patients. We investigated prevalence of hypertension and its associated risk factors in a HAART naïve HIV-infected population in Dar es Salaam, Tanzania. Methods. A cross-sectional analysis was conducted among HAART naïve HIV-infected patients. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg. Overweight and obesity were defined as body mass index (BMI) between 25...
2016: International Journal of Hypertension
https://www.readbyqxmd.com/read/27871269/institutionalizing-postpartum-intrauterine-device-iud-services-in-sri-lanka-tanzania-and-nepal-study-protocol-for-a-cluster-randomized-stepped-wedge-trial
#13
David Canning, Iqbal H Shah, Erin Pearson, Elina Pradhan, Mahesh Karra, Leigh Senderowicz, Till Bärnighausen, Donna Spiegelman, Ana Langer
BACKGROUND: During the year following the birth of a child, 40% of women are estimated to have an unmet need for contraception. The copper IUD provides safe, effective, convenient, and long-term contraceptive protection that does not interfere with breastfeeding during the postpartum period. Postpartum IUD (PPIUD) insertion should be performed by a trained provider in the early postpartum period to reduce expulsion rates and complications, but these services are not widely available. The International Federation of Obstetricians and Gynecologists (FIGO) will implement an intervention that aims to institutionalize PPIUD training as a regular part of the OB/GYN training program and to integrate it as part of the standard practice at the time of delivery in intervention hospitals...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27861238/complementary-feeding-and-diarrhea-and-respiratory-infection-among-hiv-exposed-tanzanian-infants
#14
Pili Kamenju, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Rodrick R Kisenge, Roland Kupka, Said Aboud, Karim Manji, Christopher Duggan, Wafaie W Fawzi
OBJECTIVE: To examine the association between complementary feeding and risks of diarrhea and acute respiratory infection (ARI) among HIV-exposed infants aged 6-24 months. DESIGN: We prospectively used an Infant and Child Feeding Index (ICFI) to measure complementary feeding practices (breastfeeding status, food consistency, dietary diversity, food group frequency, and meal frequency). We determined the association of ICFI and each of its components with the risk of diarrhea and ARI...
March 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27856289/rna-binding-protein-igf2bp1-in-cutaneous-squamous-cell-carcinoma
#15
TaeWon Kim, Thomas Havighurst, KyungMann Kim, Scott J Hebbring, Zhan Ye, Juliet Aylward, Sunduz Keles, Yaohui G Xu, Vladimir S Spiegelman
No abstract text is available yet for this article.
March 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27854526/evaluating-public-health-interventions-5-causal-inference-in-public-health-research-do-sex-race-and-biological-factors-cause-health-outcomes
#16
M Maria Glymour, Donna Spiegelman
Counterfactual frameworks and statistical methods for supporting causal inference are powerful tools to clarify scientific questions and guide analyses in public health research. Counterfactual accounts of causation contrast what would happen to a population's health under alternative exposure scenarios. A long-standing debate in counterfactual theory relates to whether sex, race, and biological characteristics, including obesity, should be evaluated as causes, given that these variables do not directly correspond to clearly defined interventions...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27830448/estimating-the-effect-of-intravenous-acetaminophen-for-postoperative-pain-management-on-length-of-stay-and-inpatient-hospital-costs
#17
E Eve Shaffer, An Pham, Robert L Woldman, Andrew Spiegelman, Scott A Strassels, George J Wan, Thomas Zimmerman
INTRODUCTION: The provision of safe, effective, cost-efficient perioperative inpatient acute pain management is an important concern among clinicians and administrators within healthcare institutions. Overreliance on opioid monotherapy in this setting continues to present health risks for patients and increase healthcare costs resulting from preventable adverse events. The goal of this study was to model length of stay (LOS), potential opioid-related complications, and costs for patients reducing opioid use and adding intravenous acetaminophen (IV APAP) for management of postoperative pain...
January 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27809528/structural-characterization-of-sulfur-containing-water-clusters-using-a-density-functional-based-tight-binding-approach
#18
Kseniia A Korchagina, Aude Simon, Mathias Rapacioli, Fernand Spiegelman, Jérôme Cuny
A global optimization search of low-energy isomers is carried out to investigate the structural and stability properties of sulfur-containing water clusters, including both (H2O)nSO4(2-) and (H2O)nH2SO4 aggregates. The systematic optimization algorithm involves a combination of parallel-tempering molecular dynamics and periodic gradient-driven quenches with energy and energy-gradient calculations performed using the Self-Consistent-Charge Density-Functional based Tight-Binding (SCC-DFTB) scheme. Comparisons with new MP2 and DFT calculations on the smallest systems and previous ab initio investigations of the literature show that the SCC-DFTB approach provides a fairly accurate description of both neutral and ionic species, comparable to that of DFT...
November 17, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27793143/urban-rural-and-geographic-differences-in-overweight-and-obesity-in-four-sub-saharan-african-adult-populations-a-multi-country-cross-sectional-study
#19
IkeOluwapo O Ajayi, Clement Adebamowo, Hans-Olov Adami, Shona Dalal, Megan B Diamond, Francis Bajunirwe, David Guwatudde, Marina Njelekela, Joan Nankya-Mutyoba, Faraja S Chiwanga, Jimmy Volmink, Robert Kalyesubula, Carien Laurence, Todd G Reid, Douglas Dockery, David Hemenway, Donna Spiegelman, Michelle D Holmes
BACKGROUND: Overweight and obesity are on the rise in developing countries including sub-Saharan Africa. We undertook a four-country survey to show the collective burden of these health conditions as they occur currently in sub-Saharan Africa and to determine the differences between urban and rural populations and other socio-economic factors. METHODS: Participants were nurses in two hospitals in Nigeria (200), school teachers in South Africa (489) and Tanzania (229), and village residents in one peri-urban (297) and one rural location in Uganda (200) who completed a standardised questionnaire...
October 28, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27789674/the-effect-of-neonatal-vitamin-a-supplementation-on-morbidity-and-mortality-at-12-months-a-randomized-trial
#20
Emily R Smith, Alfa Muhihi, Salum Mshamu, Christopher R Sudfeld, Ramadhani Abdallah Noor, Donna Spiegelman, Roger L Shapiro, Honorati Masanja, Wafaie Fawzi
BACKGROUND: Neonatal vitamin A supplementation (NVAS) is an intervention hypothesized to reduce infant morbidity and mortality. The objective of this study was to assess the efficacy of neonatal vitamin A supplementation in reducing infant morbidity and mortality and assess potential sources of heterogeneity of the effect of NVAS. METHODS: We completed an individually randomized, double-blind, placebo-controlled trial in Tanzania. Infants were randomized within 3 days of birth to a single dose of vitamin A (50 000 IU) or placebo...
October 27, 2016: International Journal of Epidemiology
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