keyword
MENU ▼
Read by QxMD icon Read
search

Spiegelman

keyword
https://www.readbyqxmd.com/read/28196865/s-palmitoylation-of-junctional-adhesion-molecule-c-regulates-its-tight-junction-localization-and-cell-migration
#1
Pornpun Aramsangtienchai, Nicole A Spiegelman, Ji Cao, Hening Lin
Junctional Adhesion Molecule C (JAM-C) is an immunoglobulin superfamily protein expressed in epithelial cells, endothelial cells, and leukocytes. JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell-adhesion, cell polarity, spermatogenesis and metastasis. Here, we show that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys264 and Cys265. We have identified DHHC7 as a JAM-C palmitoylating enzyme by screening all known palmitoyltransferases (PATs or DHHCs)...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28158909/teneurin-transmembrane-protein-4-is-not-a-cause-for-essential-tremor-in-a-canadian-population
#2
Gabrielle Houle, Jean-François Schmouth, Claire S Leblond, Amirthagowri Ambalavanan, Dan Spiegelman, Sandra B Laurent, Cynthia V Bourassa, Michel Panisset, Sylvain Chouinard, Nicolas Dupré, Carles Vilariño-Güell, Alex Rajput, Patrick A Dion, Guy A Rouleau
INTRODUCTION: Mutations in teneurin transmembrane protein 4 were reported to be a risk factor for essential tremor, but the relevance of this across different population remains to be examined. The aim of this study was to determine the frequency and spectrum of variations in teneurin transmembrane protein 4 in a cohort of Canadian essential tremor cases. METHODS: The coding portion of teneurin transmembrane protein 4 was sequenced in 269 unrelated essential tremor cases and 288 matched control individuals using a targeted and high-throughput sequencing approach...
February 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28115667/vitamin-a-and-zinc-supplementation-among-pregnant-women-to-prevent-placental-malaria-a-randomized-double-blind-placebo-controlled-trial-in-tanzania
#3
Anne Marie Darling, Ferdinand M Mugusi, Analee J Etheredge, Nilupa S Gunaratna, Ajibola Ibraheem Abioye, Said Aboud, Christopher Duggan, Robert Mongi, Donna Spiegelman, Drucilla Roberts, Davidson H Hamer, Kevin C Kain, Wafaie W Fawzi
Vitamin A and zinc are important for immune function and may improve host defense against malaria and reduce the risk of adverse pregnancy outcomes. Our objective was to determine whether daily oral supplementation with either or both nutrients starting in the first trimester reduces the risk of placental malaria and adverse pregnancy outcomes. We undertook a randomized, double-blind placebo-controlled trial with a factorial design among 2,500 human immunodeficiency virus-negative primigravid or secundigravid pregnant women in their first trimester of pregnancy in Dar es Salaam, Tanzania...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28093263/-cross-sectional-stepped-wedge-designs-always-reduce-the-required-sample-size-when-there-is-no-time-effect
#4
Xin Zhou, Xiaomei Liao, Donna Spiegelman
No abstract text is available yet for this article.
January 13, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28053189/function-of-cyclophilin1-as-a-long-distance-signal-molecule-in-the-phloem-of-tomato-plants
#5
Ziv Spiegelman, Sumita Omer, Ben N Mansfeld, Shmuel Wolf
Tomato (Solanum lycopersicum) diageotropica (dgt) mutants, containing a single mutation in the Cyclophilin1 (SlCyp1) gene, are auxin-insensitive, exhibiting a pleiotropic phenotype including lack of geotropism, abnormal xylem structure, lack of lateral roots (LRs), and elevated shoot-to-root ratio. SlCyp1 is a putative peptidyl-prolyl isomerase that can traffic from shoot to root, where it induces changes in auxin response, LR formation, and xylem development, suggesting it has a role as a long-distance signaling molecule...
January 4, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27974182/retraction-notice-to-activation-of-the-ppar-pgc-1%C3%AE-pathway-prevents-a-bioenergetic-deficit-and-effectively-improves-a-mitochondrial-myopathy-phenotype
#6
Tina Wenz, Francisca Diaz, Bruce M Spiegelman, Carlos T Moraes
No abstract text is available yet for this article.
13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27923781/population-attributable-risk-of-modifiable-and-nonmodifiable-breast-cancer-risk-factors-in-postmenopausal-breast-cancer
#7
Rulla M Tamimi, Donna Spiegelman, Stephanie A Smith-Warner, Molin Wang, Mathew Pazaris, Walter C Willett, A Heather Eliassen, David J Hunter
We examined the proportions of multiple types of breast cancers in the population that were attributable to established risk factors, focusing on behaviors that are modifiable at menopause. We estimated the full and partial population attributable risk percentages (PAR%) by combining the relative risks and the observed prevalence rates of the risk factors of interest. A total of 8,421 cases of invasive breast cancer developed in postmenopausal women (n = 121,700) in the Nurses' Health Study from 1980-2010...
December 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27872756/prevalence-of-hypertension-and-its-associated-risk-factors-among-34-111-haart-na%C3%A3-ve-hiv-infected-adults-in-dar-es-salaam-tanzania
#8
Marina Njelekela, Alfa Muhihi, Akum Aveika, Donna Spiegelman, Claudia Hawkins, Catharina Armstrong, Enju Liu, James Okuma, Guerino Chalamila, Sylvia Kaaya, Ferdinand Mugusi, Wafaie Fawzi
Background. Elevated blood pressure has been reported among treatment naïve HIV-infected patients. We investigated prevalence of hypertension and its associated risk factors in a HAART naïve HIV-infected population in Dar es Salaam, Tanzania. Methods. A cross-sectional analysis was conducted among HAART naïve HIV-infected patients. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg. Overweight and obesity were defined as body mass index (BMI) between 25...
2016: International Journal of Hypertension
https://www.readbyqxmd.com/read/27871269/institutionalizing-postpartum-intrauterine-device-iud-services-in-sri-lanka-tanzania-and-nepal-study-protocol-for-a-cluster-randomized-stepped-wedge-trial
#9
David Canning, Iqbal H Shah, Erin Pearson, Elina Pradhan, Mahesh Karra, Leigh Senderowicz, Till Bärnighausen, Donna Spiegelman, Ana Langer
BACKGROUND: During the year following the birth of a child, 40% of women are estimated to have an unmet need for contraception. The copper IUD provides safe, effective, convenient, and long-term contraceptive protection that does not interfere with breastfeeding during the postpartum period. Postpartum IUD (PPIUD) insertion should be performed by a trained provider in the early postpartum period to reduce expulsion rates and complications, but these services are not widely available. The International Federation of Obstetricians and Gynecologists (FIGO) will implement an intervention that aims to institutionalize PPIUD training as a regular part of the OB/GYN training program and to integrate it as part of the standard practice at the time of delivery in intervention hospitals...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27861238/complementary-feeding-and-diarrhea-and-respiratory-infection-among-hiv-exposed-tanzanian-infants
#10
Pili Kamenju, Enju Liu, Ellen Hertzmark, Donna Spiegelman, Rodrick R Kisenge, Roland Kupka, Said Aboud, Karim Manji, Christopher Duggan, Wafaie W Fawzi
OBJECTIVE: To examine the association between complementary feeding and risks of diarrhea and acute respiratory infection (ARI) among HIV-exposed infants aged 6-24 months. DESIGN: We prospectively used an Infant and Child Feeding Index (ICFI) to measure complementary feeding practices (breastfeeding status, food consistency, dietary diversity, food group frequency, and meal frequency). We determined the association of ICFI and each of its components with the risk of diarrhea and ARI...
March 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27856289/rna-binding-protein-igf2bp1-in-cutaneous-squamous-cell-carcinoma
#11
TaeWon Kim, Thomas Havighurst, KyungMann Kim, Scott J Hebbring, Zhan Ye, Juliet Aylward, Sunduz Keles, Yaohui G Xu, Vladimir S Spiegelman
No abstract text is available yet for this article.
November 14, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27854526/evaluating-public-health-interventions-5-causal-inference-in-public-health-research-do-sex-race-and-biological-factors-cause-health-outcomes
#12
M Maria Glymour, Donna Spiegelman
Counterfactual frameworks and statistical methods for supporting causal inference are powerful tools to clarify scientific questions and guide analyses in public health research. Counterfactual accounts of causation contrast what would happen to a population's health under alternative exposure scenarios. A long-standing debate in counterfactual theory relates to whether sex, race, and biological characteristics, including obesity, should be evaluated as causes, given that these variables do not directly correspond to clearly defined interventions...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27830448/estimating-the-effect-of-intravenous-acetaminophen-for-postoperative-pain-management-on-length-of-stay-and-inpatient-hospital-costs
#13
E Eve Shaffer, An Pham, Robert L Woldman, Andrew Spiegelman, Scott A Strassels, George J Wan, Thomas Zimmerman
INTRODUCTION: The provision of safe, effective, cost-efficient perioperative inpatient acute pain management is an important concern among clinicians and administrators within healthcare institutions. Overreliance on opioid monotherapy in this setting continues to present health risks for patients and increase healthcare costs resulting from preventable adverse events. The goal of this study was to model length of stay (LOS), potential opioid-related complications, and costs for patients reducing opioid use and adding intravenous acetaminophen (IV APAP) for management of postoperative pain...
January 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27809528/structural-characterization-of-sulfur-containing-water-clusters-using-a-density-functional-based-tight-binding-approach
#14
Kseniia A Korchagina, Aude Simon, Mathias Rapacioli, Fernand Spiegelman, Jérôme Cuny
A global optimization search of low-energy isomers is carried out to investigate the structural and stability properties of sulfur-containing water clusters, including both (H2O)nSO4(2-) and (H2O)nH2SO4 aggregates. The systematic optimization algorithm involves a combination of parallel-tempering molecular dynamics and periodic gradient-driven quenches with energy and energy-gradient calculations performed using the Self-Consistent-Charge Density-Functional based Tight-Binding (SCC-DFTB) scheme. Comparisons with new MP2 and DFT calculations on the smallest systems and previous ab initio investigations of the literature show that the SCC-DFTB approach provides a fairly accurate description of both neutral and ionic species, comparable to that of DFT...
November 17, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27793143/urban-rural-and-geographic-differences-in-overweight-and-obesity-in-four-sub-saharan-african-adult-populations-a-multi-country-cross-sectional-study
#15
IkeOluwapo O Ajayi, Clement Adebamowo, Hans-Olov Adami, Shona Dalal, Megan B Diamond, Francis Bajunirwe, David Guwatudde, Marina Njelekela, Joan Nankya-Mutyoba, Faraja S Chiwanga, Jimmy Volmink, Robert Kalyesubula, Carien Laurence, Todd G Reid, Douglas Dockery, David Hemenway, Donna Spiegelman, Michelle D Holmes
BACKGROUND: Overweight and obesity are on the rise in developing countries including sub-Saharan Africa. We undertook a four-country survey to show the collective burden of these health conditions as they occur currently in sub-Saharan Africa and to determine the differences between urban and rural populations and other socio-economic factors. METHODS: Participants were nurses in two hospitals in Nigeria (200), school teachers in South Africa (489) and Tanzania (229), and village residents in one peri-urban (297) and one rural location in Uganda (200) who completed a standardised questionnaire...
October 28, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27789674/the-effect-of-neonatal-vitamin-a-supplementation-on-morbidity-and-mortality-at-12-months-a-randomized-trial
#16
Emily R Smith, Alfa Muhihi, Salum Mshamu, Christopher R Sudfeld, Ramadhani Abdallah Noor, Donna Spiegelman, Roger L Shapiro, Honorati Masanja, Wafaie Fawzi
BACKGROUND: Neonatal vitamin A supplementation (NVAS) is an intervention hypothesized to reduce infant morbidity and mortality. The objective of this study was to assess the efficacy of neonatal vitamin A supplementation in reducing infant morbidity and mortality and assess potential sources of heterogeneity of the effect of NVAS. METHODS: We completed an individually randomized, double-blind, placebo-controlled trial in Tanzania. Infants were randomized within 3 days of birth to a single dose of vitamin A (50 000 IU) or placebo...
October 27, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27766318/intra-cluster-correlation-estimates-for-hiv-related-outcomes-from-care-and-treatment-clinics-in-dar-es-salaam-tanzania
#17
Dale Barnhart, Ellen Hertzmark, Enju Liu, Ester Mungure, Aisa N Muya, David Sando, Guerino Chalamilla, Nzovu Ulenga, Till Bärnighausen, Wafaie Fawzi, Donna Spiegelman
INTRODUCTION: Researchers planning cluster-randomized controlled trials (cRCTs) require estimates of the intra-cluster correlation coefficient (ICC) from previous studies for sample size calculations. This paper fills a persistent gap in the literature by providing estimates of ICCs for many key HIV-related clinical outcomes. METHODS: Data from HIV-positive patients from 47 HIV care and treatment clinics in Dar es Salaam, Tanzania were used to calculate ICCs by site of enrollment or site of ART initiation for various clinical outcomes using cross-sectional and longitudinal data...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27745834/rnf213-is-associated-with-intracranial-aneurysms-in-the-french-canadian-population
#18
Sirui Zhou, Amirthagowri Ambalavanan, Daniel Rochefort, Pingxing Xie, Cynthia V Bourassa, Pascale Hince, Alexandre Dionne-Laporte, Dan Spiegelman, Ziv Gan-Or, Cathy Mirarchi, Vessela Zaharieva, Nicolas Dupré, Hatasu Kobayashi, Toshiaki Hitomi, Kouji Harada, Akio Koizumi, Lan Xiong, Patrick A Dion, Guy A Rouleau
Intracranial aneurysms (IAs) are the result of focal weakness in the artery wall and have a complex genetic makeup. To date, genome-wide association and sequencing studies have had limited success in identifying IA risk factors. Distinct populations, such as the French-Canadian (FC) population, have increased IA prevalence. In our study, we used exome sequencing to prioritize risk variants in a discovery cohort of six FC families affected by IA, and the analysis revealed an increased variation burden for ring finger protein 213 (RNF213)...
November 3, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27741204/laparoscopically-confirmed-endometriosis-and-breast-cancer-in-the-nurses-health-study-ii
#19
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Susan E Hankinson, Wendy Y Chen, Stacey A Missmer
OBJECTIVE: To investigate the association between laparoscopically confirmed endometriosis and the risk of breast cancer. Previous research on endometriosis and breast cancer has reported mixed results. METHODS: Our prospective cohort study included 116,430 women from the Nurses' Health Study II cohort followed from 1989 until 2013. Our primary analysis investigated the association between self-reported laparoscopically confirmed endometriosis and the risk of breast cancer...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27736213/changes-in-reported-sexual-orientation-following-us-states-recognition-of-same-sex-couples
#20
Brittany M Charlton, Heather L Corliss, Donna Spiegelman, Kerry Williams, S Bryn Austin
OBJECTIVES: To compare changes in self-reported sexual orientation of women living in states with any recognition of same-sex relationships (e.g., hospital visitation, domestic partnerships) with those of women living in states without such recognition. METHODS: We calculated the likelihood of women in the Nurses' Health Study II (n = 69 790) changing their reported sexual orientation between 1995 and 2009. RESULTS: We used data from the Nurses' Health Study II and found that living in a state with same-sex relationship recognition was associated with changing one's reported sexual orientation, particularly from heterosexual to sexual minority...
December 2016: American Journal of Public Health
keyword
keyword
62564
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"