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Antidepressant efficacy

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https://www.readbyqxmd.com/read/29781509/comparative-analgesic-efficacy-of-pregabalin-administered-according-to-either-a-prevention-protocol-or-an-intervention-protocol-in-rats-with-cisplatin-induced-peripheral-neuropathy
#1
F Y Han, A Kuo, J R Nicholson, L Corradinni, M T Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is a type of peripheral neuropathic pain that may be dose-limiting in patients administered potentially curative cancer chemotherapy dosing regimens. In cancer survivors, persistent CIPN adversely affects patient quality of life and so adjuvant drugs (anticonvulsants e.g. pregabalin or antidepressants e.g. amitriptyline) are recommended for the relief of CIPN. However, most studies in rodent models of CIPN involve administration of single bolus doses of adjuvant drugs to assess pain-relieving efficacy...
May 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29780430/healthcare-professionals-perceptions-on-the-emotional-impact-of-having-an-inadequate-response-to-antidepressant-medications-survey-and-prospective-patient-audit
#2
Rajnish Mago, Andrea Fagiolini, Emmanuelle Weiller, Catherine Weiss
Background: Despite the availability of effective antidepressants, about half of patients with major depressive disorder (MDD) display an inadequate response to their initial treatment. A large patient survey recently reported that 29.8% of MDD patients experiencing an inadequate treatment response felt frustrated about their medication and 19.2% were frustrated with their healthcare provider. This survey and chart audit evaluated healthcare professionals' (HCP) views on the emotional impact of having an inadequate response to antidepressant medication...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29776950/clinical-effects-and-safety-of-electroacupuncture-for-the-treatment-of-post-stroke-depression-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#3
Xue-Bin Li, Jie Wang, An-Ding Xu, Jian-Min Huang, Lan-Qing Meng, Rui-Ya Huang, Jing Xu
OBJECTIVE: The aim of this systematic review was to assess the efficacy/effectiveness and safety of electroacupuncture (EA) in the treatment of post-stroke depression (PSD). METHODS: A comprehensive literature search in the Pubmed, Embase, CENTRAL, ISI Web of Science, CNKI and Wanfang databases was conducted, and all relevant randomised controlled trials (RCTs) were screened for eligibility by two independent reviewers. The Cochrane Collaboration's tool and Jadad score were used to assess the risk of bias of included studies, and only RCTs scoring ≥3 were included in a meta-analysis...
May 18, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29761479/antidepressants-for-insomnia-in-adults
#4
REVIEW
Hazel Everitt, David S Baldwin, Beth Stuart, Gosia Lipinska, Andrew Mayers, Andrea L Malizia, Christopher Cf Manson, Sue Wilson
BACKGROUND: Insomnia disorder is a subjective condition of unsatisfactory sleep (e.g. sleep onset, maintenance, early waking, impairment of daytime functioning). Insomnia disorder impairs quality of life and is associated with an increased risk of physical and mental health problems including anxiety, depression, drug and alcohol abuse, and increased health service use. hypnotic medications (e.g. benzodiazepines and 'Z' drugs) are licensed for sleep promotion, but can induce tolerance and dependence, although many people remain on long-term treatment...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29753049/antidepressant-effects-of-creatine-on-amyloid-%C3%AE-1-40-treated-mice-the-role-of-gsk-3%C3%AE-nrf-2-pathway
#5
Julia M Rosa, Francis L Pazini, Mauricio P Cunha, André R S Colla, Luana M Manosso, Gianni Mancini, Ana Cristina G Souza, Andreza F de Bem, Rui Daniel Prediger, Ana Lúcia S Rodrigues
Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction and neuronal lost in specific brain areas including hippocampus, resulting in memory/learning deficits and cognitive impairments. In addition, non-cognitive symptoms are reported in AD patients, such as anxiety, apathy and depressed mood. The current antidepressant drugs present reduced efficacy to improve depressive symptoms in AD patients. Here, we investigated the ability of creatine, a compound with neuroprotective and antidepressant properties, to counteract amyloid β1-40 peptide-induced depressive-like behavior in mice...
May 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29747670/the-efficacy-and-safety-of-jiedu-tongluo-granules-for-treating-post-stroke-depression-with-qi-deficiency-and-blood-stasis-syndrome-study-protocol-for-a-randomized-controlled-trial
#6
Ai-Mei Zhao, Wen-Ran Qiu, Li-Jun Mao, Jun-Guo Ren, Li Xu, Ming-Jiang Yao, Kellie Bilinksi, Dennis Chang, Jian-Xun Liu
BACKGROUND: Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chinese medicine has been used to treat PSD with few side effects. The aim of this study is to evaluate the efficacy and safety of Jiedu Tongluo granules for treating PSD with qi deficiency and blood stasis syndrome...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29745454/effects-of-short-term-clomipramine-on-anxiety-like-behavior-cellular-metabolism-and-oxidative-stress-in-primary-fibroblast-cells-of-male-and-female-rats
#7
Ana G Jimenez, Joshua D Winward, Dana M Smith, Christina M Ragan
Anxiety is the most prevalent mental disorder among adults in the United States and females tend to have significantly higher rates of anxiety compared with men. Common treatments for anxiety include usage of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, however, sex differences in the efficacy of these drugs exist. In this study, we were interested in determining if acutely manipulating serotonin mechanisms at the whole-animal level affects cellular metabolism and oxidative stress in primary fibroblast cells from clomipramine-treated Sprague-Dawley rats...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29742912/the-impact-of-a-long-term-rivastigmine-and-donepezil-treatment-on-all-cause-mortality-in-patients-with-alzheimer-s-disease
#8
Jakub Kazmierski, Chaido Messini-Zachou, Mara Gkioka, Magda Tsolaki
Cholinesterase inhibitors (ChEIs) are the mainstays of symptomatic treatment of Alzheimer's disease (AD); however, their efficacy is limited, and their use was associated with deaths in some groups of patients. The aim of the current study was to assess the impact of the long-term use of ChEIs on mortality in patients with AD. This observational, longitudinal study included 1171 adult patients with a diagnosis of AD treated with donepezil or rivastigmine. Each patient was observed for 24 months or until death...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29742266/efficacy-acceptability-and-tolerability-of-antidepressant-treatments-for-patients-with-post-stroke-depression-a-network-meta-analysis
#9
B Qin, H Chen, W Gao, L B Zhao, M J Zhao, H X Qin, W Chen, L Chen, M X Yang
The aim of this study was to investigate the efficacy, acceptability, and tolerability of antidepressants in treating post-stroke depression (PSD) by performing a network meta-analysis of randomized controlled trials of the current literature. Eligible studies were retrieved from online databases, and relevant data were extracted. The primary outcome was efficacy as measured by the mean change in overall depressive symptoms. Secondary outcomes included discontinued treatment for any reason and specifically due to adverse events...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29742109/effect-of-single-dose-imipramine-on-chronic-low-back-and-experimental-pain-a-randomized-controlled-trial
#10
Jürg Schliessbach, Andreas Siegenthaler, Lukas Bütikofer, Andreas Limacher, Peter Juni, Pascal H Vuilleumier, Ulrike Stamer, Lars Arendt-Nielsen, Michele Curatolo
Antidepressants are frequently prescribed as co-analgesics in chronic pain. While their efficacy is well documented for neuropathic pain, the evidence is less clear in musculoskeletal pain conditions. The present study therefore evaluated the effect of the tricyclic antidepressant imipramine on chronic low-back pain in a randomized, double-blinded placebo-controlled design. To explore the mechanisms of action and the influence of drug metabolism, multimodal quantitative sensory tests (QST) and genotyping for cytochrome P450 2D6 (CYP2D6) were additionally performed...
2018: PloS One
https://www.readbyqxmd.com/read/29741917/a-systematic-review-of-pharmacologic-treatments-for-school-refusal-behavior
#11
Amalia Londono Tobon, Margot O Reed, Jerome H Taylor, Michael H Bloch
OBJECTIVE: School refusal is an important pediatric problem with significant negative short- and long-term outcomes. Specific psychosocial treatments appear effective in reducing school refusal, but many children do not respond to these treatments. Although systematic reviews have examined the efficacy of psychological interventions for school refusal, no systematic reviews on pharmacological interventions exist. METHODS: We conducted a comprehensive literature search of MEDLINE, PsycINFO, Scopus, and Embase for randomized controlled trials (RCTs) or quasi-experimental pharmacologic trials in children and adolescents with school refusal reported in English or Spanish until July 1, 2017...
May 9, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29738811/hypobaric-hypoxia-exposure-in-rats-differentially-alters-antidepressant-efficacy-of-the-selective-serotonin-reuptake-inhibitors-fluoxetine-paroxetine-escitalopram-and-sertraline
#12
Shami Kanekar, Chandni S Sheth, Hendrik J Ombach, Paul R Olson, Olena V Bogdanova, Matthew Petersen, Chloe E Renshaw, Young-Hoon Sung, Kristen E D'Anci, Perry F Renshaw
Treatment-resistant depression, a chronic condition that affects 30% of depressed patients on antidepressants, is highly linked to suicidal behavior. Chronic hypoxia exposure via living at altitude (hypobaric hypoxia) or with chronic hypoxic diseases is demographically linked to increased risk for depression and suicide. We previously demonstrated that housing rats at altitude for a week incrementally increases depression-like behavior in the forced swim test (FST) in females, but not males. In animal models, high altitude exposure reduces brain serotonin, and selective serotonin reuptake inhibitors (SSRIs) can lose efficacy when brain serotonin levels are low...
May 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29738425/a-pilot-open-label-8-week-study-evaluating-desvenlafaxine-for-treatment-of-major-depression-in-methadone-maintained-individuals-with-opioid-use-disorder
#13
Cynthia El Hage, Maykel F Ghabrash, Simon Dubreucq, Suzanne Brissette, François Lespérance, Paul Lespérance, Clairélaine Ouellet-Plamondon, Julie Bruneau, Didier Jutras-Aswad
Depression is one of the most prevalent psychiatric disorders among opioid-dependent individuals. Clinical trials testing selective serotonin reuptake inhibitors among depressed patients on methadone maintenance therapy (MMT) failed to show efficacy, whereas those on tricyclic antidepressants produced mixed results with potential for cardiotoxicity. Desvenlafaxine (DESV) is a SNRI with minimal cardiotoxicity and drug interactions. This study sought to assess feasibility and tolerability of using DESV in depressed patients on MMT...
May 7, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29736744/antidepressant-efficacy-and-tolerability-of-ketamine-and-esketamine-a-critical-review
#14
REVIEW
P Molero, J A Ramos-Quiroga, R Martin-Santos, E Calvo-Sánchez, L Gutiérrez-Rojas, J J Meana
Ketamine and its enantiomer S-ketamine (esketamine) are promising candidates to produce a rapid-onset antidepressant effect in treatment-resistant depression. Ketamine causes continued blockade of the glutamate N-methyl-D-aspartate (NMDA) receptor, though this might not primarily mediate the antidepressant effect. Alternative hypotheses include selectivity for the NMDA receptor subtype containing the NMDA receptor subunit 2B (NR2B), inhibition of the phosphorylation of the eukaryotic elongation factor 2 (eEF2) kinase, increased expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrKB), and activation of the mammalian target of rapamycin (mTOR) signaling pathway, alongside other independent actions attributed to the ketamine metabolism to R-hydroxynorketamine (R-HNK)...
May 7, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29736128/mechanism-of-repetitive-transcranial-magnetic-stimulation-for-depression
#15
REVIEW
Zhengwu Peng, Cuihong Zhou, Shanshan Xue, Jie Bai, Shoufen Yu, Xiaosa Li, Huaning Wang, Qingrong Tan
Depressive disorder is one of the most common mental health problems currently. However, the mechanism-based treatments for this disorder remain elusive. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive procedure that could stimulate electrical activity by a pulsed magnetic field in the brain, is considered to be an effective treatment for depression. Here, we review the main findings from both clinical and basic research on rTMS for depression, including its antidepressant efficacy, basic principles, as well as its ability to regulate neural circuits, neurotransmitters and brain networks, neurogenesis in hippocampus, and synaptic, and molecular pathways...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29734488/virtual-reality-exposure-versus-prolonged-exposure-for-ptsd-which-treatment-for-whom
#16
Aaron M Norr, Derek J Smolenski, Andrea C Katz, Albert A Rizzo, Barbara O Rothbaum, JoAnn Difede, Patricia Koenen-Woods, Mark A Reger, Greg M Reger
BACKGROUND: The majority of studies comparing active psychological treatments for posttraumatic stress disorder (PTSD) do not find significant differences at posttreatment. This was the case in a recent trial examining prolonged exposure (PE) and virtual reality exposure (VRE) among active-duty soldiers with combat-related PTSD. Matching individual patients to specific treatments provides a potential avenue to improve significantly the public health impact of effective treatments for PTSD...
May 7, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29734455/response-to-agomelatine-treatment-is-independent-of-smoking-status-and-dosage-results-from-the-agopsych-study
#17
Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Sarah Eisenacher, Jascha Thiem, Andreas Meyer-Lindenberg, Mathias Zink
INTRODUCTION: Cigarette smoking influences response to antidepressant treatment. It accelerates the metabolism of several cytochrome P450 (CYP) subtypes, including CYP1A2, and therefore bears the risk of pharmacokinetic interactions with psychotropic drugs using that pathway. Agomelatine is a substrate of CYP1A2; the association between nicotine use and agomelatine dosage, however, has never been studied before. METHODS: Smoking habits were correlated with agomelatine doses and treatment outcomes in a sample of 27 patients with lifetime diagnoses within the schizophrenia spectrum who received agomelatine treatment in addition to their stable antipsychotic treatment regimen because of depressive symptoms...
May 7, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29732584/giving-priority-to-preclinical-pain-measures-resistant-to-existing-drugs-for-developing-innovative-analgesics
#18
Yukinori Nagakura
Preclinical Research & Development Chronic pain is a major health and socioeconomic burden because of its high prevalence, negative influence on patients' physical and/or emotional conditions, and huge costs to society. The responses of chronic pain patients to analgesic therapies vary substantially from individual to individual, and no more than a minority of chronic pain patients with various etiologies such as neuropathy and inflammation are, in fact, successfully relieved by existing drugs including opioid analgesics, nonopioid analgesics, antiepileptics, and antidepressants...
May 6, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29727467/pharmacological-interventions-for-apathy-in-alzheimer-s-disease
#19
REVIEW
Myuri T Ruthirakuhan, Nathan Herrmann, Eleenor H Abraham, Sarah Chan, Krista L Lanctôt
BACKGROUND: Despite the high prevalence of apathy in Alzheimer's disease (AD), and its harmful effects, there are currently no therapies proven to treat this symptom. Recently, a number of pharmacological therapies have been investigated as potential treatments for apathy in AD. OBJECTIVES: Objective 1: To assess the safety and efficacy of pharmacotherapies for the treatment of apathy in Alzheimer's disease (AD).Objective 2: To assess the effect on apathy of pharmacotherapies investigated for other primary outcomes in the treatment of AD...
May 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29725086/gene-based-analysis-of-genes-related-to-neurotrophic-pathway-suggests-association-of-bdnf-and-vegfa-with-antidepressant-treatment-response-in-depressed-patients
#20
Chung-Feng Kao, Yu-Li Liu, Younger W-Y Yu, Albert C Yang, Eugene Lin, Po-Hsiu Kuo, Shih-Jen Tsai
It is well established that brain-derived neurotrophic factor (BDNF) signaling pathway plays a key role in the pathophysiology of major depressive disorder (MDD) and in therapeutic mechanisms of antidepressants. We aim to identify genetic vairiants related to MDD susceptibility and antidepressant therapeutic response by using gene-based association analysis with genes related to the neurotrophic pathway. The present study investigated the role of genetic variants in the 10 neurotrophic-related genes (BDNF, NGFR, NTRK2, MTOR, VEGFA, S100A10, SERPINE1, ARHGAP33, GSK3B, CREB1) in MDD susceptibility through a case-control (455 MDD patients and 2,998 healthy controls) study and in antidepressant efficacy (n = 455)...
May 3, 2018: Scientific Reports
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