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Metabolomics Cardiovascular

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https://www.readbyqxmd.com/read/29678183/a-randomized-controlled-cross-over-trial-investigating-the-effect-of-anti-inflammatory-diet-on-disease-activity-and-quality-of-life-in-rheumatoid-arthritis-the-anti-inflammatory-diet-in-rheumatoid-arthritis-adira-study-protocol
#1
Anna Winkvist, Linnea Bärebring, Inger Gjertsson, Lars Ellegård, Helen M Lindqvist
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects 0.5-1.0% of the population, and where many patients in spite of modern pharmacological treatment fail to reach remission. This affects physical as well as mental wellbeing and leads to severely reduced quality of life and reduced work capacity, thus yielding high individual as well as societal costs. As a complement to modern pharmacological treatment, lifestyle intervention should be evaluated as a treatment option...
April 20, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29648650/nafld-risk-alleles-in-pnpla3-tm6sf2-gckr-and-lyplal1-show-divergent-metabolic-effects
#2
Eeva Sliz, Sylvain Sebert, Peter Würtz, Antti J Kangas, Pasi Soininen, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Minna Männikkö, Mika Ala-Korpela, Olli T Raitakari, Johannes Kettunen
Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic association profiles of genotypes increasing the risk of non-alcoholic fatty liver disease (NAFLD). The cross-sectional associations of ultrasound-ascertained fatty liver with 123 metabolic measures were determined in 1,810 (Nfatty liver=338) individuals aged 34-49 years from The Cardiovascular Risk in Young Finns Study...
April 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29628193/metabolism-metabolomics-and-inflammation-in-posttraumatic-stress-disorder
#3
REVIEW
Synthia H Mellon, Aarti Gautam, Rasha Hammamieh, Marti Jett, Owen M Wolkowitz
Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations, although among the characteristics are significantly increased rates of serious somatic comorbidities, such as cardiovascular disease, immune dysfunction, and metabolic syndrome. In this review, we assess the evidence for disturbances that may contribute to somatic pathology in inflammation, metabolic syndrome, and circulating metabolites (implicating mitochondrial dysfunction) in individuals with PTSD and in animal models simulating features of PTSD...
February 22, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29563342/untargeted-metabolomics-identifies-trimethyllysine-a-tmao-producing-nutrient-precursor-as-a-predictor-of-incident-cardiovascular-disease-risk
#4
Xinmin S Li, Zeneng Wang, Tomas Cajka, Jennifer A Buffa, Ina Nemet, Alex G Hurd, Xiaodong Gu, Sarah M Skye, Adam B Roberts, Yuping Wu, Lin Li, Christopher J Shahen, Matthew A Wagner, Jaana A Hartiala, Robert L Kerby, Kymberleigh A Romano, Yi Han, Slayman Obeid, Thomas F Lüscher, Hooman Allayee, Federico E Rey, Joseph A DiDonato, Oliver Fiehn, W H Wilson Tang, Stanley L Hazen
Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts (N = 1,162), we discovered and structurally identified a plasma metabolite associated with cardiovascular disease (CVD) risks, N6,N6,N6-trimethyl-L-lysine (trimethyllysine, TML). Stable-isotope-dilution tandem mass spectrometry analyses of an independent validation cohort (N = 2,140) confirmed TML levels are independently associated with incident (3-year) major adverse cardiovascular event risks (hazards ratio [HR], 2...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29562256/metabolomic-profiling-of-atherosclerotic-plaques-towards-improved-cardiovascular-risk-stratification
#5
Emiel P C van der Vorst, Christian Weber
No abstract text is available yet for this article.
March 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29562241/altered-metabolism-distinguishes-high-risk-from-stable-carotid-atherosclerotic-plaques
#6
Lukas Tomas, Andreas Edsfeldt, Inês G Mollet, Ljubica Perisic Matic, Cornelia Prehn, Jerzy Adamski, Gabrielle Paulsson-Berne, Ulf Hedin, Jan Nilsson, Eva Bengtsson, Isabel Gonçalves, Harry Björkbacka
Aims: Identification and treatment of the rupture prone atherosclerotic plaque remains a challenge for reducing the burden of cardiovascular disease. The interconnection of metabolic and inflammatory processes in rupture prone plaques is poorly understood. Herein, we investigate associations between metabolite profiles, inflammatory mediators and vulnerability in carotid atherosclerotic plaques. Methods and results: We collected 159 carotid plaques from patients undergoing endarterectomy and measured 165 different metabolites in a targeted metabolomics approach...
March 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29559272/amino-acid-levels-in-nascent-metabolic-syndrome-a-contributor-to-the-pro-inflammatory-burden
#7
Priya Reddy, Joseph Leong, Ishwarlal Jialal
AIMS: Metabolic Syndrome (MetS) is a cluster of cardio-metabolic risk factors characterized by low-grade inflammation which confers an increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Prior studies have linked elevated branched chain amino acids (BCAA) and aromatic amino acids (AAA) with T2DM and CVD. Due to the paucity of data in MetS, the aim of this study was to investigate the status of amino acids as early biomarkers of nascent MetS patients without T2DM and CVD or smoking...
March 9, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29555771/precision-medicine-screening-using-whole-genome-sequencing-and-advanced-imaging-to-identify-disease-risk-in-adults
#8
Bradley A Perkins, C Thomas Caskey, Pamila Brar, Eric Dec, David S Karow, Andrew M Kahn, Ying-Chen Claire Hou, Naisha Shah, Debbie Boeldt, Erin Coughlin, Gabby Hands, Victor Lavrenko, James Yu, Andrea Procko, Julia Appis, Anders M Dale, Lining Guo, Thomas J Jönsson, Bryan M Wittmann, Istvan Bartha, Smriti Ramakrishnan, Axel Bernal, James B Brewer, Suzanne Brewerton, William H Biggs, Yaron Turpaz, J Craig Venter
Reducing premature mortality associated with age-related chronic diseases, such as cancer and cardiovascular disease, is an urgent priority. We report early results using genomics in combination with advanced imaging and other clinical testing to proactively screen for age-related chronic disease risk among adults. We enrolled active, symptom-free adults in a study of screening for age-related chronic diseases associated with premature mortality. In addition to personal and family medical history and other clinical testing, we obtained whole-genome sequencing (WGS), noncontrast whole-body MRI, dual-energy X-ray absorptiometry (DXA), global metabolomics, a new blood test for prediabetes (Quantose IR), echocardiography (ECHO), ECG, and cardiac rhythm monitoring to identify age-related chronic disease risks...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29555466/non-targeted-metabolomic-biomarkers-and-metabotypes-of-type-2-diabetes-a-cross-sectional-study-of-predimed-trial-participants
#9
M Urpi-Sarda, E Almanza-Aguilera, R Llorach, R Vázquez-Fresno, R Estruch, D Corella, J V Sorli, F Carmona, A Sanchez-Pla, J Salas-Salvadó, C Andres-Lacueva
AIM: To characterize the urinary metabolomic fingerprint and multi-metabolite signature associated with type 2 diabetes (T2D), and to classify the population into metabotypes related to T2D. METHODS: A metabolomics analysis using the1 H-NMR-based, non-targeted metabolomic approach was conducted to determine the urinary metabolomic fingerprint of T2D compared with non-T2D participants in the PREDIMED trial. The discriminant metabolite fingerprint was subjected to logistic regression analysis and ROC analyses to establish and to assess the multi-metabolite signature of T2D prevalence, respectively...
February 20, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29506183/characterization-of-metabolic-responses-to-healthy-diets-and-association-with-blood-pressure-application-to-the-optimal-macronutrient-intake-trial-for-heart-health-omniheart-a-randomized-controlled-study
#10
Ruey Leng Loo, Xin Zou, Lawrence J Appel, Jeremy K Nicholson, Elaine Holmes
Background: Interindividual variation in the response to diet is common, but the underlying mechanism for such variation is unclear. Objective: The objective of this study was to use a metabolic profiling approach to identify a panel of urinary metabolites representing individuals demonstrating typical (homogeneous) metabolic responses to healthy diets, and subsequently to define the association of these metabolites with improvement of risk factors for cardiovascular diseases (CVDs)...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29498300/arsenic-induces-cardiac-rhythm-dysfunction-and-acylcarnitines-metabolism-perturbation-in-rats
#11
Nam Nhut Phan, Kuan-Lun Li, Yen-Chang Lin
BACKGROUND: Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS: In this study, different concentrations of arsenic were orally applied to Sprague Dawley rats in order to examine the relationship between arsenic and cardiovascular rhythm (i.e. long QT) via electrocardiography measurement...
March 2, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29483187/comparative-and-integrative-metabolomics-reveal-that-s-nitrosation-inhibits-physiologically-relevant-metabolic-enzymes
#12
Joel J Bruegger, Brian C Smith, Sarah L Wynia-Smith, Michael A Marletta
Cysteine S-nitrosation is a reversible posttranslational modification mediated by nitric oxide (·NO)-derived agents. S-nitrosation participates in cellular signaling and is associated with several diseases such as cancer, cardiovascular diseases, and neuronal disorders. Despite the physiological importance of this nonclassical ·NO signaling pathway, little is understood about how much S-nitrosation affects protein function. Moreover, identifying physiologically relevant targets of S-nitrosation is difficult because of the dynamics of transnitrosation and a limited understanding of the physiological mechanisms leading to selective protein S-nitrosation...
February 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29468148/polyamines-bio-molecules-with-diverse-functions-in-plant-and-human-health-and-disease
#13
REVIEW
Avtar K Handa, Tahira Fatima, Autar K Mattoo
Biogenic amines-polyamines (PAs), particularly putrescine, spermidine and spermine are ubiquitous in all living cells. Their indispensable roles in many biochemical and physiological processes are becoming commonly known, including promoters of plant life and differential roles in human health and disease. PAs positively impact cellular functions in plants-exemplified by increasing longevity, reviving physiological memory, enhancing carbon and nitrogen resource allocation/signaling, as well as in plant development and responses to extreme environments...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29459470/metabolic-predictors-of-incident-coronary-heart-disease-in-women
#14
Nina P Paynter, Raji Balasubramanian, Franco Giulianini, Dong D Wang, Lesley F Tinker, Shuba Gopal, Amy A Deik, Kevin Bullock, Kerry A Pierce, Justin Scott, Miguel A Martínez-González, Ramon Estruch, JoAnn E Manson, Nancy R Cook, Christine M Albert, Clary B Clish, Kathryn M Rexrode
BACKGROUND: Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS: We applied a liquid chromatography-tandem mass spectrometry metabolomics platform to measure 371 metabolites in a discovery set of postmenopausal women (472 incident CHD cases, 472 controls) with validation in an independent set of postmenopausal women (312 incident CHD cases, 315 controls)...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29457805/urinary-metabolomic-study-of-the-antagonistic-effect-of-p-ginseng-in-rats-with-estrogen-decline-using-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#15
He Lin, Zhongying Liu, Zifeng Pi, Lihui Men, Weijia Chen, Zhiqiang Liu
Estrogens are biologically active steroid hormones mainly released from the ovary by ovarian secretion of estrogen into the circulating blood to regulate or function at the distal target. Estrogens play an important role in the central nervous system, cardiovascular system and immune system, especially for post-menopausal women. Panax ginseng Mayer has been reported to relieve women's menopausal symptoms and affect estrogen activities. However, the mechanism of its estrogen regulation has not yet been clearly investigated...
February 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29432757/a-novel-nmr-based-assay-to-measure-circulating-concentrations-of-branched-chain-amino-acids-elevation-in-subjects-with-type-2-diabetes-mellitus-and-association-with-carotid-intima-media-thickness
#16
Justyna Wolak-Dinsmore, Eke G Gruppen, Irina Shalaurova, Steven P Matyus, Russell P Grant, Ray Gegen, Stephan J L Bakker, James D Otvos, Margery A Connelly, Robin P F Dullaart
OBJECTIVES: Plasma branched-chain amino acid (BCAA) levels, measured on nuclear magnetic resonance (NMR) metabolomics research platforms or by mass spectrometry, have been shown to be associated with type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). We developed a new test for quantification of BCAA on a clinical NMR analyzer and used this test to determine the clinical correlates of BCAA in 2 independent cohorts. DESIGN AND METHODS: The performance of the NMR-based BCAA assay was evaluated...
April 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29429278/-the-relationship-between-gut-microbiota-and-diet-and-nutrition-related-diseases
#17
M Q Wang, Y Li, C H Sun
The human gastro-intestinal tract is not only the habitat of gut microbiota, but also the main place that the body gets available nutrients. Therefore, the gut microbiota of human can be inseparable associated with the human nutrition. The common technologies used among gut microbiota research included metageonomic, metatranscriptomics, metaproteomics, and metabolomics. The research of gut microbiota based on above omics methods confirmed that diets were the main factors influencing the composition and expression of gut microbiota...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29414920/interventional-left-atrial-appendage-closure-affects-the-metabolism-of-acylcarnitines
#18
Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. METHODS: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i...
February 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29400994/advances-in-understanding-the-molecular-basis-of-the-mediterranean-diet-effect
#19
Dolores Corella, Oscar Coltell, Fernando Macian, José M Ordovás
Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. The scientific evidence level for each outcome is variable, and new studies are needed to better understand the molecular mechanisms whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases but also discussing other related diseases...
March 25, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29390044/serum-metabolomic-profiling-of-all-cause-mortality-a-prospective-analysis-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study-cohort
#20
Jiaqi Huang, Stephanie J Weinstein, Steven C Moore, Andriy Derkach, Xing Hua, Linda M Liao, Fangyi Gu, Alison M Mondul, Joshua N Sampson, Demetrius Albanes
Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of overall and cardiovascular disease (CVD) mortality worldwide, yet the relevant metabolic alterations responsible are largely unknown. We conducted a serum metabolomic analysis of 620 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2013). During 28 years of follow-up, there were 435 deaths (197 CVD and 107 cancer). The analysis included 406 known metabolites measured with ultra-high performance liquid chromatography/mass spectrometry-gas chromatography/mass spectrometry...
January 30, 2018: American Journal of Epidemiology
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