keyword
MENU ▼
Read by QxMD icon Read
search

Metabolomics Cardiovascular

keyword
https://www.readbyqxmd.com/read/28645211/akr1c3-mediated-adipose-androgen-generation-drives-lipotoxicity-in-women-with-polycystic-ovary-syndrome
#1
Michael W O'Reilly, Punith Kempegowda, Mark Walsh, Angela E Taylor, Konstantinos N Manolopoulos, J William Allwood, Robert K Semple, Daniel Hebenstreit, Warwick B Dunn, Jeremy W Tomlinson, Wiebke Arlt
Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS...
June 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28638045/treatment-of-sarcopenia-and-glucose-intolerance-through-mitochondrial-activation-by-5-aminolevulinic-acid
#2
Chikako Fujii, Kazutoshi Miyashita, Masanori Mitsuishi, Masaaki Sato, Kentaro Fujii, Hiroyuki Inoue, Aika Hagiwara, Sho Endo, Asuka Uto, Masaki Ryuzaki, Motowo Nakajima, Tohru Tanaka, Masanori Tamaki, Ayako Muraki, Toshihide Kawai, Hiroshi Itoh
Recently, sarcopenia has attracted attention as therapeutic target because it constitutes a risk factor for metabolic and cardiovascular diseases. We focused 5-aminolevulinic acid (ALA) which act as electron carriers in the mitochondrial electron transport system. The mice that received ALA for 8 weeks gained muscle strength and endurance, and exhibited increased muscle mass and mitochondrial amount. Administration of ALA to sarcopenia mice aged 100 weeks and chronic kidney disease (CKD) model mice also increased muscle mass and improved physical performance...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632785/the-association-between-various-smoking-behaviors-cotinine-biomarkers-and-skin-autofluorescence-a-marker-for-advanced-glycation-end-product-accumulation
#3
Robert P van Waateringe, Marjonneke J Mook-Kanamori, Sandra N Slagter, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Helen L Lutgers, Karsten Suhre, Mohammed M El-Din Selim, Dennis O Mook-Kanamori, Bruce H R Wolffenbuttel
BACKGROUND: Skin autofluorescence, a biomarker for advanced glycation end products (AGEs) accumulation, has been shown to predict diabetes-related cardiovascular complications and is associated with several environmental and lifestyle factors. In the present study, we examined the association between various smoking behaviors and skin autofluorescence, as well as the association between several cotinine biomarkers and skin autofluorescence, using both epidemiological and metabolomics data...
2017: PloS One
https://www.readbyqxmd.com/read/28619388/metabolomics-highlights-pharmacological-bioactivity-and-biochemical-mechanism-of-traditional-chinese-medicine
#4
REVIEW
Ming Wang, Lin Chen, Dan Liu, Hua Chen, Dan-Dan Tang, Ying-Yong Zhao
Traditional Chinese medicine (TCM) has attracted increasing interest throughout the world because of its potential complementary therapy and an abundant source for new drug discovery. TCM possesses the significant bioactivity of the use of multi-component drugs and can act multiple targets by multiple components. Metabolomics is a holistic investigation of numerous metabolite responses of complex biology systems to pathological stimuli and drug treatments based on the global metabolic profiles in complex biological matrixes...
June 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28614056/spermine-and-spermidine-reversed-age-related-cardiac-deterioration-in-rats
#5
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian, Yajun Zhao
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608394/a-discovery-driven-approach-to-elucidate-urinary-metabolome-changes-after-a-regular-and-moderate-consumption-of-beer-and-non-alcoholic-beer-in-subjects-at-high-cardiovascular-risk
#6
Paola Quifer-Rada, Gemma Chiva-Blanch, Olga Jáuregui, Ramon Estruch, Rosa M Lamuela-Raventos
SCOPE: The aim of this work was to study the urinary metabolomics changes of participants that consumed beer, non-alcoholic beer and gin. METHODS AND RESULTS: Thirty-three males at high cardiovascular risk between 55 and 75 years old participated in an open, randomized, crossover, controlled trial with three nutritional interventions consisting of beer, non-alcoholic beer and gin for four weeks. Diet and physical activity was monitored throughout the study and compliance was assessed by measurement of urinary isoxanthohumol...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28606513/serum-metabolomics-analysis-reveals-that-obvious-cardioprotective-effects-of-low-dose-sini-decoction-against-isoproterenol-induced-myocardial-injury-in-rats
#7
Jun Zhou, Xiaoqiong Ma, Min Shi, Cuiwei Chen, Yue Sun, Jingjing Li, Youxiang Xiong, Junjie Chen, Fanzhu Li
BACKGROUND: Sini decoction (SND) is used for cardiovascular disease over thousands of years in China. However, it is still lacking of dose-response relationship of SND in cardiovascular disease at the metabolic level. PURPOSE: The present study is designed to explore the cardioprotective effects of different dosages of SND pretreatment on the isoproterenol (ISO)-induced myocardial injury and elucidate the mechanism underlying this protective effect. METHODS: The cardioprotective effects of different dosages of SND pretreatment on the isoproterenol-induced myocardial injury were compared through a serum metabolomics approach based on ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS)...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28599201/serum-metabolome-biomarkers-associate-low-level-environmental-perfluorinated-compound-exposure-with-oxidative-nitrosative-stress-in-humans
#8
Xiaofei Wang, Liangpo Liu, Weibing Zhang, Jie Zhang, Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen
Previous in vivo and in vitro studies have linked perfluorinated compound (PFC) exposure with metabolic interruption, but the inter-species difference and high treatment doses usually make the results difficult to be extrapolated to humans directly. The best strategy for identifying the metabolic interruption may be to establish the direct correlations between monitored PFCs data and metabolic data on human samples. In this study, serum metabolome data and PFC concentrations were acquired for a Chinese adult male cohort...
June 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28585834/acute-consumption-of-flavan-3-ol-enriched-dark-chocolate-affects-human-endogenous-metabolism
#9
Luisa Martha Ostertag, Mark Philo, Ian J Colquhoun, Henri S Tapp, Shikha Saha, Garry G Duthie, E Kate Kemsley, Baukje de Roos, Paul A Kroon, Gwénaëlle Le Gall
Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled cross-over intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 h and 6 h after consumption of chocolates in 42 healthy volunteers using a non-targeted metabolomics approach...
June 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28583012/exhaled-breath-analysis-in-obstructive-sleep-apnea
#10
Esther I Schwarz, Anna Engler, Malcolm Kohler
Breath analysis is a novel application that can be used for non-invasive metabolic phenotyping and identification of disease specific breath patterns. Obstructive sleep apnea (OSA) is highly prevalent and has diverse metabolic and cardiovascular consequences, many of them incompletely understood. Areas covered: This review systematically summarizes the current evidence from breath metabolomics using immunoassays of breath condensate, off-line mass spectrometry as well as real-time analysis by electronic sensors and by untargeted mass spectrometry, and discusses the challenges and perspectives of breath analysis in OSA...
June 14, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28571562/advantages-and-limitations-of-current-biomarker-research-from-experimental-research-to-clinical-application
#11
Seung-Hyun Kim, Christel Weiß, Ursula Hoffmann, Martin Borggrefe
BACKGROUND: Biomarkers are indispensable tools for screening, diagnosis, and prognosis in cardiovascular diseases and their clinical application increases steadily. As cardiovascular diseases include various pathophysiological processes, no single biomarker, even natriuretic peptides, can be regarded as ideal fulfilling all necessary criteria for a comprehensive diagnostic or prognostic assessment revealing optimal clinical application. Hence, the multi-marker approaches using different biomarkers reflecting different pathophysiologies were highlighted recently...
May 31, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28566446/cortisol-related-metabolic-alterations-assessed-by-mass-spectrometry-assay-in-patients-with-cushing-s-syndrome
#12
Guido Di Dalmazi, Marcus Quinkler, Timo Deutschbein, Cornelia Prehn, Nada Rayes, Matthias Kroiss, Christina Maria Berr, Günter K Stalla, Martin Fassnacht, Jerzy Adamski, Martin Reincke, Felix Beuschlein
OBJECTIVE: Endogenous hypercortisolism is a chronic condition associated with severe metabolic disturbances and cardiovascular sequela. The aim of this study was to characterize metabolic alterations in patients with different degrees of hypercortisolism by mass-spectrometry-based targeted plasma metabolomic profiling and correlate the metabolomic profile with clinical and hormonal data. DESIGN: Cross-sectional study. METHODS: Subjects (n=149) were classified according to clinical and hormonal characteristics: Cushing's syndrome (n=46), adrenocortical adenomas with autonomous cortisol secretion (n=31) or without hypercortisolism (n=27)...
May 31, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28549934/in-vitro-metabolomic-approaches-to-investigating-the-potential-biological-effects-of-phenolic-compounds-an-update
#13
REVIEW
Úrsula Catalán, Laura Barrubés, Rosa Maria Valls, Rosa Solà, Laura Rubió
Dietary phenolic compounds (PCs) have been receiving interest for their presumed roles in disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In this regard, in vitro metabolomic approaches are suitable for the investigation of the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been examined for PCs from rosemary (Rosmarinus officinalis), olive oil, and resveratrol using cell-based metabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vitro cell experiment in some cases...
May 23, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/28547736/rice-bran-metabolome-contains-amino-acids-vitamins-cofactors-and-phytochemicals-with-medicinal-and-nutritional-properties
#14
Iman Zarei, Dustin G Brown, Nora Jean Nealon, Elizabeth P Ryan
BACKGROUND: Rice bran is a functional food that has shown protection against major chronic diseases (e.g. obesity, diabetes, cardiovascular disease and cancer) in animals and humans, and these health effects have been associated with the presence of bioactive phytochemicals. Food metabolomics uses multiple chromatography and mass spectrometry platforms to detect and identify a diverse range of small molecules with high sensitivity and precision, and has not been completed for rice bran...
December 2017: Rice
https://www.readbyqxmd.com/read/28542544/development-and-characterization-of-an-experimental-model-of-diet-induced-metabolic-syndrome-in-rabbit
#15
Oscar Julián Arias-Mutis, Vannina G Marrachelli, Amparo Ruiz-Saurí, Antonio Alberola, Jose Manuel Morales, Luis Such-Miquel, Daniel Monleon, Francisco J Chorro, Luis Such, Manuel Zarzoso
Metabolic syndrome (MetS) has become one of the main concerns for public health because of its link to cardiovascular disease. Murine models have been used to study the effect of MetS on the cardiovascular system, but they have limitations for studying cardiac electrophysiology. In contrast, the rabbit cardiac electrophysiology is similar to human, but a detailed characterization of the different components of MetS in this animal is still needed. Our objective was to develop and characterize a diet-induced experimental model of MetS that allows the study of cardiovascular remodeling and arrhythmogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28482123/integrative-analysis-of-transcriptomic-and-metabolomic-data-via-sparse-canonical-correlation-analysis-with-incorporation-of-biological-information
#16
Sandra E Safo, Shuzhao Li, Qi Long
Integrative analysis of high dimensional omics data is becoming increasingly popular. At the same time, incorporating known functional relationships among variables in analysis of omics data has been shown to help elucidate underlying mechanisms for complex diseases. In this article, our goal is to assess association between transcriptomic and metabolomic data from a Predictive Health Institute (PHI) study that includes healthy adults at a high risk of developing cardiovascular diseases. Adopting a strategy that is both data-driven and knowledge-based, we develop statistical methods for sparse canonical correlation analysis (CCA) with incorporation of known biological information...
May 8, 2017: Biometrics
https://www.readbyqxmd.com/read/28422753/steroid-metabolome-analysis-reveals-prevalent-glucocorticoid-excess-in-primary-aldosteronism
#17
Wiebke Arlt, Katharina Lang, Alice J Sitch, Anna S Dietz, Yara Rhayem, Irina Bancos, Annette Feuchtinger, Vasileios Chortis, Lorna C Gilligan, Philippe Ludwig, Anna Riester, Evelyn Asbach, Beverly A Hughes, Donna M O'Neil, Martin Bidlingmaier, Jeremy W Tomlinson, Zaki K Hassan-Smith, D Aled Rees, Christian Adolf, Stefanie Hahner, Marcus Quinkler, Tanja Dekkers, Jaap Deinum, Michael Biehl, Brian G Keevil, Cedric H L Shackleton, Jonathan J Deeks, Axel K Walch, Felix Beuschlein, Martin Reincke
BACKGROUND: Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and osteoporosis, which cannot be easily explained by aldosterone excess. METHODS: We performed mass spectrometry-based analysis of a 24-hour urine steroid metabolome in 174 newly diagnosed patients with primary aldosteronism (103 unilateral adenomas, 71 bilateral adrenal hyperplasias) in comparison to 162 healthy controls, 56 patients with endocrine inactive adrenal adenoma, 104 patients with mild subclinical, and 47 with clinically overt adrenal cortisol excess...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28416032/physiological-metabolic-and-transcriptional-postnatal-phenotypes-of-in-vitro-fertilization-ivf-in-the-mouse
#18
S K Feuer, P F Rinaudo
Approximately 1-4% of children today are conceived using assisted reproductive technologies (ARTs), including in vitro fertilization (IVF). IVF is considered safe and the great majority of these children are healthy, yet there is increasing physiological and molecular evidence from animal models that ART is associated with postnatal metabolic and cardiovascular alterations. Understanding the mechanisms underlying these changes and determining whether they have biological significance is of paramount importance for optimizing the design of culture conditions and improving the health of ART children across the life course...
April 18, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28410399/altered-glucose-metabolism-and-hypoxic-response-in-alloxan-induced-diabetic-atherosclerosis-in-rabbits
#19
Yunosuke Matsuura, Atsushi Yamashita, Yan Zhao, Takashi Iwakiri, Kazuaki Yamasaki, Chihiro Sugita, Chihiro Koshimoto, Kazuo Kitamura, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
Diabetes mellitus accelerates atherosclerosis that causes most cardiovascular events. Several metabolic pathways are considered to contribute to the development of atherosclerosis, but comprehensive metabolic alterations to atherosclerotic arterial cells remain unknown. The present study investigated metabolic changes and their relationship to vascular histopathological changes in the atherosclerotic arteries of rabbits with alloxan-induced diabetes. Diabetic atherosclerosis was induced in rabbit ilio-femoral arteries by injecting alloxan (100 mg/kg), injuring the arteries using a balloon, and feeding with a 0...
2017: PloS One
https://www.readbyqxmd.com/read/28389555/targeting-of-microbe-derived-metabolites-to-improve-human-health-the-next-frontier-for-drug-discovery
#20
REVIEW
J Mark Brown, Stanley L Hazen
Recent advances in metabolomic and genome mining approaches have uncovered a poorly understood metabolome that originates solely or in part from bacterial enzyme sources. Whether living on exposed surfaces or within our intestinal tract, our microbial inhabitants produce a remarkably diverse set of natural products and small molecule metabolites that can impact human health and disease. Highlighted here, the gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the development of cardiovascular diseases...
May 26, 2017: Journal of Biological Chemistry
keyword
keyword
62560
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"