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https://www.readbyqxmd.com/read/28539541/sleep-disordered-breathing-in-heart-failure%C3%A3-a-therapeutic-dilemma
#1
Nobuhiko Haruki, John S Floras
Sleep-disordered breathing (SDB) occurs in approximately 50% of patients with reduced left ventricular ejection fraction receiving contemporary heart failure (HF) therapies. Obstructive (OSA) and central sleep apneas (CSA) interrupt breathing by different mechanisms but impose qualitatively similar autonomic, chemical, mechanical, and inflammatory burdens on the heart and circulation. Because contemporary evidence-based drug and device HF therapies have little or no mitigating effect on the acute or long-term consequences of such stimuli, there is a sound mechanistic rationale for targeting SDB to reduce cardiovascular event rates and prolong life...
June 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28391734/analysis-of-tracheostoma-morphology
#2
Maartje Leemans, Maarten J A van Alphen, Michiel W M van den Brekel, Edsko E G Hekman
OBJECTIVES: Existing fixation methods of automatic speaking valves (ASVs) suffer from shortcomings which partly are the result of insufficient conformity of the intratracheal fixation method's shape to the tracheostoma anatomy. However, quantitative data are lacking and will be helpful to analyse solutions for airtight fixation. This article provides such data. PATIENTS AND METHODS: The tracheostoma morphology was measured in computerized tomography scans of 20 laryngectomized patients...
April 10, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28335841/cardiovascular-outcomes-with-minute%C3%A2-ventilation-targeted-adaptive-servo-ventilation-therapy-in-heart-failure-the-cat-hf-trial
#3
RANDOMIZED CONTROLLED TRIAL
Christopher M O'Connor, David J Whellan, Mona Fiuzat, Naresh M Punjabi, Gudaye Tasissa, Kevin J Anstrom, Adam V Benjafield, Holger Woehrle, Amy B Blase, JoAnn Lindenfeld, Olaf Oldenberg
BACKGROUND: Sleep apnea is common in hospitalized heart failure (HF) patients and is associated with increased morbidity and mortality. OBJECTIVES: The CAT-HF (Cardiovascular Improvements With MV-ASV Therapy in Heart Failure) trial investigated whether minute ventilation (MV) adaptive servo-ventilation (ASV) improved cardiovascular outcomes in hospitalized HF patients with moderate-to-severe sleep apnea. METHODS: Eligible patients hospitalized with HF and moderate-to-severe sleep apnea were randomized to ASV plus optimized medical therapy (OMT) or OMT alone (control)...
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28331381/retrospective-nonrandomized-controlled-study-on-autoadjusting-dual-pressure-positive-airway-pressure-therapy-for-a-consecutive-series-of-complex-insomnia-disorder-patients
#4
Barry Krakow, Natalia D McIver, Victor A Ulibarri, Michael R Nadorff
PURPOSE: Emerging evidence shows that positive airway pressure (PAP) treatment of obstructive sleep apnea (OSA) and upper airway resistance syndrome (UARS) in chronic insomnia patients (proposed "complex insomnia" disorder) leads to substantial decreases in insomnia severity. Although continuous PAP (CPAP) is the pressure mode most widely researched, intolerance to fixed pressurized air is rarely investigated or described in comorbidity patients. This retrospective study examined dual pressure, autoadjusting PAP modes in chronic, complex insomnia disorder patients...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28224905/emerging-trends-in-biosensing-using-stripping-voltammetric-detection-of-metal-containing-nanolabels-a-review
#5
REVIEW
Christos Kokkinos, Anastasios Economou
Over the last years, nanomaterials have found many applications in the development of electrochemical biosensors. Among other functions, metal nanoparticles (NPs) and quantum dots (QDs) (semiconducting nanocrystals composed of metal salts) are increasingly being used as voltammetric labels in affinity biosensing. Labeling is based on the attachment of the label(s) on the target biomolecules or on a biorecognition reporting probe. After an appropriate specific affinity interaction between the target and the reporting probe, the metallic nanolabels are converted to the respective cations which are quantified by a voltammetric technique...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27637753/a-prospective-multicenter-clinical-feasibility-study-of-a-new-automatic-speaking-valve-for-postlaryngectomy-voice-rehabilitation
#6
MULTICENTER STUDY
L Lansaat, B J de Kleijn, F J M Hilgers, B F A M van der Laan, M W M van den Brekel
Evaluation of short- and long-term clinical feasibility and exploration of limitations and advantages of a new automatic speaking valve (ASV) for laryngectomized patients with integrated HME, the Provox FreeHands FlexiVoice (FlexiVoice). This ASV not only enables automatic, but also manual closure of the valve. A multicenter, prospective clinical study in 40 laryngectomized patients was conducted. Participants were asked to use the FlexiVoice for 26 weeks. The primary outcome measure was long-term compliance...
February 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27478974/advanced-positive-airway-pressure-modes-adaptive-servo-ventilation-and-volume-assured-pressure-support
#7
REVIEW
Bernardo Selim, Kannan Ramar
INTRODUCTION: Volume assured pressure support (VAPS) and adaptive servo ventilation (ASV) are non-invasive positive airway pressure (PAP) modes with sophisticated negative feedback control systems (servomechanism), having the capability to self-adjust in real time its respiratory controlled variables to patient's respiratory fluctuations. However, the widespread use of VAPS and ASV is limited by scant clinical experience, high costs, and the incomplete understanding of propriety algorithmic differences in devices' response to patient's respiratory changes...
September 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27257985/lab-on-a-membrane-foldable-devices-for-duplex-drop-volume-electrochemical-biosensing-using-quantum-dot-tags
#8
Christos Kokkinos, Michailia Angelopoulou, Anastasios Economou, Mamas Prodromidis, Ageliki Florou, Willem Haasnoot, Panagiota Petrou, Sotirios Kakabakos
This work describes a new type of integrated lab-on-a-membrane foldable device suitable for on-site duplex electrochemical biosensing using drop-size sample volumes. The devices are fabricated entirely by screen-printing on a nylon membrane and feature two assay zones which are located symmetrically on either side of a three-electrode voltammetric cell with a bismuth citrate-loaded graphite working electrode. After the completion of two spatially separated drop-volume competitive immunoassays on the assay zones using biotinylated antibodies labeled with streptavidin-conjugated Pb- and Cd-based quantum dots (QDs), respectively, the QD labels are dissolved releasing Pb(II) and Cd(II) in the assay zones...
July 5, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/26296413/heterogenous-haemodynamic-effects-of-adaptive-servoventilation-therapy-in-sleeping-patients-with-heart-failure-and-cheyne-stokes-respiration-compared-to-healthy-volunteers
#9
Jens Spießhöfer, Henrik Fox, Roman Lehmann, Christina Efken, Jessica Heinrich, Thomas Bitter, Britta Körber, Dieter Horstkotte, Olaf Oldenburg
This study investigated the haemodynamic effects of adaptive servoventilation (ASV) in heart failure (HF) patients with Cheyne-Stokes respiration (CSR) versus healthy controls. Twenty-seven HF patients with CSR and 15 volunteers were ventilated for 1 h using a new ASV device (PaceWave™). Haemodynamics were continuously and non-invasively recorded at baseline, during ASV and after ventilation. Prior to the actual study, a small validation study was performed to validate non-invasive measurement of Stroke volume index (SVI)...
July 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25950507/the-use-of-a-fully-automated-automatic-adaptive-servoventilation-algorithm-in-the-acute-and-long-term-treatment-of-central-sleep-apnea
#10
MULTICENTER STUDY
Shahrokh Javaheri, David Winslow, Pamela McCullough, Paul Wylie, Meir H Kryger
BACKGROUND: Central sleep apnea (CSA), in association with obstructive disordered breathing, occurs in patients using opioids long-term and those with congestive heart failure. In these patients, treatment with CPAP frequently fails. The current adaptive servoventilation (ASV) devices are promising for the treatment of complex sleep-disordered breathing. These devices use algorithms to automatically titrate expiratory and inspiratory pressures. We hypothesized that an ASV device operating automatically would significantly reduce the frequency of breathing events in patients with mixed sleep apnea during polysomnography and with 3 months of treatment...
December 2015: Chest
https://www.readbyqxmd.com/read/25928620/effects-of-adaptive-servo-ventilation-therapy-on-cardiac-function-and-remodeling-in-patients-with-chronic-heart-failure-savior-c-study-protocol-for-a-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Yoshihiko Seino, Shin-Ichi Momomura, Yasuki Kihara, Hitoshi Adachi, Yoshio Yasumura, Hiroyuki Yokoyama
BACKGROUND: Adaptive servo-ventilation (ASV) therapy, which is a form of noninvasive positive pressure ventilation therapy and uses an innovative ventilator that has simple operability and provides good patient adherence, potentially has therapeutic benefits-suppression of the deterioration and progression of chronic heart failure (CHF) and a reduction in the number of repeated hospitalizations. Therefore, ASV therapy draws attention as a novel, noninvasive nonpharmacotherapy for patients with CHF owing to its hemodynamics-improving effect, and it is currently being accepted in real-world clinical settings in Japan...
2015: Trials
https://www.readbyqxmd.com/read/25871423/respiratory-effects-of-adaptive-servoventilation-therapy-in-patients-with-heart-failure-and-cheyne-stokes-respiration-compared-to-healthy-volunteers
#12
COMPARATIVE STUDY
Jens Spießhöfer, Jessica Heinrich, Roman Lehmann, Christina Efken, Henrik Fox, Thomas Bitter, Britta Körber, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Nocturnal adaptive servoventilation (ASV) therapy is now frequently used to treat Cheyne-Stokes respiration (CSR), which is highly prevalent in patients with moderate-to-severe heart failure (HF) and characterized by periodical breathing (hyperventilation). OBJECTIVES: This study analyzed and compared the acute effects of a novel ASV device on carbon dioxide pressure (pCO2) and oxygen saturation (SaO2) in HF patients with CSR and healthy volunteers. The influence of being asleep or awake on the ASV algorithm was also determined...
2015: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/25809453/acute-response-test-to-adaptive-servo-ventilation-a-possible-modality-to-assessing-the-reversibility-of-pulmonary-vascular-resistance
#13
Michinari Hieda, Osamu Seguchi, Yoshihiro Mutara, Haruki Sunami, Takuma Sato, Masanobu Yanase, Hata Hiroki, Tomoyuki Fujita, Takeshi Nakatani
Since pulmonary hypertension (PH) due to left-sided heart failure (HF) with elevated pulmonary vascular resistance (PVR) is contraindication for heart transplantation (HTx), correct evaluation of reversibility in PVR is essential for adequate therapeutic decision-making. However, guidelines or recommended protocols for pharmacological testing to evaluate the reversibility of PVR have not been established yet. In this report, we presented a 34-year-old male with advanced HF complicated by severe PH with high PVR [5...
September 2015: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/25778554/effects-of-adaptive-servo-ventilation-therapy-on-cardiac-function-and-remodeling-in-patients-with-chronic-heart-failure-savior-c-study-protocol-for-a-randomized-controlled-trial
#14
Yoshihiko Seino, Shin-Ichi Momomura, Yasuki Kihara, Hitoshi Adachi, Yoshio Yasumura, Hiroyuki Yokoyama
BACKGROUND: Adaptive servo-ventilation (ASV) therapy, which is a form of noninvasive positive pressure ventilation therapy and uses an innovative ventilator that has simple operability and provides good patient adherence, potentially has therapeutic benefits-suppression of the deterioration and progression of chronic heart failure (CHF) and a reduction in the number of repeated hospitalizations. Therefore, ASV therapy draws attention as a novel, noninvasive nonpharmacotherapy for patients with CHF owing to its hemodynamics-improving effect, and it is currently being accepted in real-world clinical settings in Japan...
December 2015: Trials
https://www.readbyqxmd.com/read/25413958/performance-of-conventional-and-enhanced-adaptive-servoventilation-asv-in-heart-failure-patients-with-central-sleep-apnea-who-have-adapted-to-conventional-asv
#15
RANDOMIZED CONTROLLED TRIAL
Olaf Oldenburg, Jens Spießhöfer, Henrik Fox, Natalie Prib, Dieter Horstkotte
PURPOSE: Adaptive servo-ventilation (ASV) is a positive pressure ventilator support system to normalize ventilation in patients with Cheyne-Stokes respiration (CSR). The latest generation enhanced ASV device (PaceWave; ResMed) has a new feature--auto-adjustment of EPAP. This study tested the hypothesis that enhanced ASV with auto-adjustment of EPAP (PaceWave) is non-inferior to conventional ASV (AutoSetCS). METHODS: This prospective, randomized, crossover, single-center study enrolled adult patients with stable heart failure (HF) and moderate-to-severe sleep-disordered breathing (SDB) who had been receiving conventional ASV therapy for at least 4 weeks...
September 2015: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/25180729/clinical-applications-of-adaptive-servoventilation-devices-part-2
#16
REVIEW
Shahrokh Javaheri, Lee K Brown, Winfried J Randerath
Adaptive servoventilation (ASV) is an automated treatment modality used to treat many types of sleep-disordered breathing. Although default settings are available, clinician-specified settings determined in the sleep laboratory are preferred. Depending on the device, setting choices may include a fixed expiratory positive airway pressure (EPAP) level or a range for autotitrating EPAP; minimum and maximum inspiratory positive airway pressure or pressure support values; and type of backup rate algorithm or a selectable fixed backup rate...
September 2014: Chest
https://www.readbyqxmd.com/read/25096015/electrochemical-sensor-with-substitutional-stripping-voltammetry-for-highly-sensitive-endotoxin-assay
#17
Shinichiro Takano, Kumi Y Inoue, Satoko Takahashi, Kosuke Ino, Hitoshi Shiku, Tomokazu Matsue
We have developed a novel method for detection of endotoxin with extra-high sensitivity by using substitutional stripping voltammetry (SSV). In this method, a p-aminophenol (pAP) conjugated peptide (Boc-Leu-Gly-Arg-pAP; LGR-pAP) was used as a substrate for a protease, which is activated at the last step of the endotoxin-induced Limulus amebocyte lysate (LAL) cascade reaction. Extra-highly sensitive detection of pAP liberated by the endotoxin-induced LAL reaction was successfully realized with SSV, based on the accumulation of an amperometric signal owing to exchange of the oxidation current of pAP generated at an electrode in a reaction cell with silver deposition on another electrode in a deposition cell...
October 7, 2014: Analyst
https://www.readbyqxmd.com/read/25091757/positive-airway-pressure-therapy-with-adaptive-servoventilation-part-1-operational-algorithms
#18
REVIEW
Shahrokh Javaheri, Lee K Brown, Winfried J Randerath
The beginning of the 21st century witnessed the advent of new positive airway pressure (PAP) technologies for the treatment of central and complex (mixtures of obstructive and central) sleep apnea syndromes. Adaptive servoventilation (ASV) devices applied noninvasively via mask that act to maintain a stable level of ventilation regardless of mechanism are now widely available. These PAP devices function by continually measuring either minute ventilation or airflow to calculate a target ventilation to be applied as needed...
August 2014: Chest
https://www.readbyqxmd.com/read/24932143/adaptive-servoventilation-for-treatment-of-opioid-associated-central-sleep-apnea
#19
Shahrokh Javaheri, Nicholas Harris, Joseph Howard, Eugene Chung
RATIONALE: Opioids have become part of contemporary treatment in the management of chronic pain. Although severe daytime ventilatory depression is uncommon, chronic use of opioids could be associated with severe central and obstructive sleep apnea. OBJECTIVES: To determine the acute efficacy, and prolonged use of adaptive servoventilation (ASV) to treat central sleep apnea in patients on chronic opioids. METHODS: Twenty patients on opioid therapy referred for evaluation of obstructive sleep apnea (OSA) were found to have central sleep apnea (CSA)...
June 15, 2014: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/24881587/adaptive-servo-ventilation-therapy-improves-long-term-prognosis-in-heart-failure-patients-with-anemia-and-sleep-disordered-breathing
#20
Satoshi Suzuki, Akiomi Yoshihisa, Makiko Miyata, Takamasa Sato, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yasuchika Takeishi
Sleep disordered breathing (SDB) and anemia influences the progression of chronic heart failure (CHF). Adaptive servo-ventilation (ASV) is an effective therapeutic device for treatment of CHF, however, the impacts of ASV on CHF patients with or without anemia remain unclear.A total of 139 patients with CHF and SDB were divided into two groups: those treated with ASV (n = 53) and without ASV (n = 86). All patients were prospectively followed after discharge with the endpoints of cardiac death or progressive heart failure requiring rehospitalization...
2014: International Heart Journal
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