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Neglect syndrome

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https://www.readbyqxmd.com/read/29225776/the-sedentary-r-evolution-have-we-lost-our-metabolic-flexibility
#1
Jens Freese, Rainer Johannes Klement, Begoña Ruiz-Núñez, Sebastian Schwarz, Helmut Lötzerich
During the course of evolution, up until the agricultural revolution, environmental fluctuations forced the human species to develop a flexible metabolism in order to adapt its energy needs to various climate, seasonal and vegetation conditions. Metabolic flexibility safeguarded human survival independent of food availability. In modern times, humans switched their primal lifestyle towards a constant availability of energy-dense, yet often nutrient-deficient, foods, persistent psycho-emotional stressors and a lack of exercise...
2017: F1000Research
https://www.readbyqxmd.com/read/29213232/stress-induced-chronic-visceral-pain-of-gastrointestinal-origin
#2
REVIEW
Beverley Greenwood-Van Meerveld, Anthony C Johnson
Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and depression. The mechanisms linking visceral pain with these overlapping comorbidities remain to be elucidated. Evidence suggests that long term stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic visceral pain disorders such as irritable bowel syndrome (IBS)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29203746/-effectiveness-of-early-physiotherapy-treatment-for-ischaemic-stroke-patients-suffering-intercurrently-from-post-stroke-depression-and-or-hemispatial-neglect-syndromes
#3
Justyna Ćwieląg, Marta Woldańska-Okońska
Wstęp: Depresja poudarowa i zespoł pomijania stronnego są jednymi z szeregu zaburzeń neurologicznych występujących jako konsekwencje incydentu udarowego. Oba zaburzenia uważa się za czynniki negatywnie wpływające na szybszy powrot pacjenta do zdrowia. Zadaniem wczesnej fizjoterapii po incydencie udarowym jest poprawa funkcji motorycznych oraz poprawa jakości życia pacjenta. Materiał i metody: W badaniu wzięło udział 51 pacjentow zakwalifikowanych do wzięcia udziału w "Narodowym Programie Profilaktyki i Leczenia Chorob Układu Sercowo-Naczyniowego na lata 2006-2008 POLCARD"...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29201154/lymphatic-system-and-gut-microbiota-affect-immunopathology-of-neuroinflammatory-diseases-including-multiple-sclerosis-neuromyelitis-optica-and-alzheimer-s-disease
#4
Ikuo Tsunoda
Microbial infections lead to neurological damages either by direct infection in the nervous tissues or by uncontrolled immune responses (immunopathology). For example, in Zika virus infection, microcephaly can be caused by the former, i.e., direct viral infection in the brain, while Guillain-Barré syndrome (GBS) seems to be antibody-mediated immunopathology. Although a variety of factors affect immunopathology, two essential systems maintaining whole-body homeostasis had long been neglected: 1) the lymphatic system and 2) microbiota...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29199507/asymmetric-oculomotor-apraxia-optic-ataxia-and-simultanagnosia-with-right-hemispatial-neglect-from-a-predominantly-left-sided-lesion-of-the-parieto-occipital-area
#5
Yasuhisa Sakurai, Masanori Fujimoto, Kensuke Hamada, Izumi Sugimoto
INTRODUCTION: Bálint's syndrome involves bilateral damage to the parieto-occipital area. The extent of the effect of unilateral damage on the Bálint's triad (oculomotor apraxia, optic ataxia, and simultanagnosia) remains unknown. METHODS: We examined a 63-year-old, right-handed woman who developed right hemianopia, oculomotor apraxia, optic ataxia, simultanagnosia, and hemispatial neglect (HSN) for the right after a cerebral infarction, with detailed neuropsychological tests, magnetic resonance imaging, and single photon emission computed tomography (SPECT)...
December 2, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29192535/prism-adaptation-in-rehabilitation-no-additional-effects-of-prism-adaptation-on-neglect-recovery-in-the-subacute-phase-poststroke-a-randomized-controlled-trial
#6
Antonia F Ten Brink, Johanna M A Visser-Meily, Martijn J Schut, Mirjam Kouwenhoven, Anja L H Eijsackers, Tanja C W Nijboer
BACKGROUND: Patients with neglect ignore or respond slower to contralesional stimuli. Neglect negatively influences independence in activities of daily living (ADL). Prism adaptation (PA) is one of the most frequently studied treatments, yet there is little evidence regarding positive effects on neglect behavior in ADL. OBJECTIVE: To assess whether PA in the subacute phase ameliorates neglect in situations of varying complexity. METHODS: A total of 70 neglect patients admitted for inpatient stroke rehabilitation received either PA or sham adaptation (SA) for 2 weeks, with full access to standard treatment...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29190328/the-computational-anatomy-of-visual-neglect
#7
Thomas Parr, Karl J Friston
Visual neglect is a debilitating neuropsychological phenomenon that has many clinical implications and-in cognitive neuroscience-offers an important lesion deficit model. In this article, we describe a computational model of visual neglect based upon active inference. Our objective is to establish a computational and neurophysiological process theory that can be used to disambiguate among the various causes of this important syndrome; namely, a computational neuropsychology of visual neglect. We introduce a Bayes optimal model based upon Markov decision processes that reproduces the visual searches induced by the line cancellation task (used to characterize visual neglect at the bedside)...
November 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29189299/global-orientation-in-space-and-the-lateralization-of-brain-functions
#8
Marianne Dieterich, Thomas Brandt
PURPOSE OF REVIEW: The functional role of the vestibular system for multisensory orientation and sensorimotor control is reviewed with a special focus on hemispherical lateralization and its consequences for neurological disorders of higher cortical function. RECENT FINDINGS: The peripheral and central vestibular systems are bilaterally organized with ipsilateral and contralateral ascending pathways and two multisensory cortical networks in the right and left hemisphere...
November 20, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29179846/-supporting-people-with-diogenes-syndrome
#9
REVIEW
Claire Patry, Sylvain Closier, Élise Lafon, Corine Carlier-Verhaeghe, Angélique Kerrien, Armelle Bertrand, Emmanuelle Caudron
Diogenes syndrome is a chronic condition often affecting elderly people, especially those living in isolation. It is characterised by self-neglect and compulsive hoarding. Medico-social professionals working with people in their home, have reflected on levers to help improve the complex support of these patients.
December 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/29174652/introduction-novel-hybrid-combinations-containing-synthetic-or-antibiotic-drugs-with-plant-derived-phenolic-or-terpenoid-compounds
#10
Hildebert Wagner, Thomas Efferth
BACKGROUND: There is a paradigm shift in chemotherapy from mono-drug therapy towards multidrug combination regimens. Natural products from medicinal plants may play an important role for the design of novel combination therapy protocols. HYPOTHESIS: We introduce the novel term "hybrid combination" for the therapeutic combination of chemically defined plant-derived constituents (e.g. phenolic or terpenoid compounds with synthetic or antibiotic drugs to increase pharmacological activity and simultaneously toxic side effects...
November 2, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29174259/cardiac-cachexia-in-sub-saharan-africa
#11
REVIEW
Antonio Grimaldi, Annalisa De Concilio, Luca Marsero, Maxwell Odida
Cachexia is a public health challenge around the Globe but data on prevalence rates in developing countries are very scarce. In sub-Saharan Africa wasting syndrome is mainly related to malaria, HIV infections, tuberculosis and end-stage heart disease and always associated with high-mortality and dismal quality of life regardless of age, urban or rural setting. We report two different cases affected by cardiac cachexia related to end-stage heart disease. The large age gap between patients highlights the current impact of medical services in Uganda ranging from low-resource rural settings to urban areas of the capital city under epidemiologic transition...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29165208/case-report-first-coinfection-report-of-mixed-leishmania-infantum-leishmania-major-and-human-immunodeficiency-virus-acquired-immune-deficiency-syndrome-report-of-a-case-of-disseminated-cutaneous-leishmaniasis-in-iran
#12
Alireza Badirzadeh, Mehdi Mohebali, Sadaf Sabzevari, Majid Ghafoori, Kourosh Arzamani, Mohammad Seyyedin, Seyed Ahmad Hashemi
Visceral leishmaniasis, a neglected tropical disease, is the third most common opportunistic disease in immunosuppressed patients, such as those affected by the human immunodeficiency virus (HIV)/acquired immune deficiency syndrome. Although the reports have been characterized as Leishmania/HIV coinfections, the occurrence of a mixed infection by two Leishmania species in HIV-positive patients is rare. Here, we present an atypical case of disseminated cutaneous leishmaniasis (DCL) in a 26-year-old HIV-positive man...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29163331/the-mobility-assessment-course-for-the-diagnosis-of-spatial-neglect-taking-a-step-forward
#13
Megan Grech, Tracey Stuart, Lindy Williams, Celia Chen, Tobias Loetscher
Spatial neglect after stroke can be a challenging syndrome to diagnose under standard neuropsychological assessment. There is now sufficient evidence that those affected might demonstrate neglect behavior in everyday settings despite showing no signs of neglect during common neglect tasks. This discrepancy is attributed to the simplified and unrealistic nature of common pen and paper based tasks that do not match the demanding, novel, and complex environment of everyday life. As such, increasing task demands under more ecologically valid scenarios has become an important method of increasing test sensitivity...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29159982/temple-syndrome-as-a-differential-diagnosis-to-prader-willi-syndrome-identifying-three-new-patients
#14
Asgeir Lande, Mette Kroken, Kai Rabben, Lars Retterstøl
The two imprinting syndromes Temple syndrome (TS14) and Prader-Willi syndrome (PWS) share many features in infancy and childhood. TS14 is an important, yet often neglected, differential diagnosis to PWS. We wanted to assess the frequency of TS14 among patients tested for PWS. In all samples submitted to our lab for genetic PWS testing during 2014 and 2015, we consecutively conducted additional analyses for TS14. A total of 143 samples were included. The most frequent indications for testing were developmental delay, overweight, and hypotonia...
November 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29151479/a-case-of-loeffler-endocarditis-that-showed-endomyocardial-systolic-dysfunction-detected-by-layer-specific-strain-analysis
#15
Xuanyi Jin, Chunyan Ma, Yonghuai Wang, Jun Yang
Loeffler endocarditis is a rare comprehensive cardiac manifestation caused by eosinophilic cell infiltrations and is present in 50%-60% of patients with hypereosinophilic syndrome (HES). Left ventricle (LV) endocardial systolic dysfunction is a major cause of morbidity and mortality in HES and Loeffler endocarditis. We present a case of Loeffler endocarditis, whose left ventricular (LV) systolic dysfunction and endocardial systolic dysfunction were first neglected by conventional transthoracic echocardiography (TTE), but were later pointed out by layer-specific longitudinal strain analysis...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29146727/primary-intraventricular-haemorrhage-due-to-rupture-of-giant-varix-of-the-basal-vein-of-rosenthal-in-a-patient-with-long-standing-direct-ccf-angiographic-features-and-treatment-considerations
#16
Chinmay P Nagesh, Aneesh Mohimen, Santhosh K Kannath, Jayadevan E Rajan
Direct carotid cavernous fistulae (CCF) are often detected early and treated promptly resulting in a paucity of literature regarding its long-term evolution. We present a case of high flow post-traumatic direct CCF that was neglected for over 6 years and presented with a rare manifestation of primary intraventricular haemorrhage. Occlusions of the primary venous outlets likely resulted in engorgement of the deep venous system. The segmental anatomy of the shunting basal vein is critical to the clinical presentation and may range from basal ganglia or brainstem oedema/infarctions to uniquely, as in our case, isolated intraventricular haemorrhage secondary to variceal rupture...
November 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29146711/ethics-health-policy-and-zika-from-emergency-to-global-epidemic
#17
Euzebiusz Jamrozik, Michael J Selgelid
Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation (PAHO), with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting the PAHO ethics guidance and the role of ethics in emergency responses, before turning to ethical issues that are yet to be resolved...
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29145178/minor-hemisphere-major-syndromes
#18
Antonio Carota, Julien Bogousslavsky
A right "minor hemisphere" does not exist as the right hemisphere is dominant for awareness (nosognosia), spatial attention, emotional regulation, facial and voice expressions, visual recognition, and topographical orientation. Without the right hemisphere, the world would be flat, deprived of general and spatial attentions, pointing preferentially to the right side of the space, lacking visual experiences and emotions, exhibiting diminished awareness of the self and environment. Clinical-related syndromes of the right hemisphere are unilateral spatial neglect, object and face visual agnosia, the anosognosia for hemiparesis and/or hemianopia, misidentification syndromes, mania, and other obsessions for the food and the body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29126176/hand-arm-vibration-in-orthopaedic-surgery-a-neglected-risk
#19
F Mahmood, K B Ferguson, J Clarke, K Hill, E B Macdonald, D J M Macdonald
Background: Hand-arm vibration syndrome is an occupational disease caused by exposure to hand-arm transmitted vibration. The Health and Safety Executive has set limits for vibration exposure, including an exposure action value (EAV), where steps should be taken to reduce exposure, and an exposure limit value (ELV), beyond which vibrating equipment must not be used for the rest of the working day. Aims: To measure hand-arm transmitted vibration among orthopaedic surgeons, who routinely use hand-operated saws...
November 6, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29108463/td-the-case-of-diogenes-syndrome-deficit-or-denial
#20
Fiona Ashworth, Anita Rose, Barbara A Wilson
Diogenes Syndrome (DS) is characterised by extreme self-neglect, domestic squalor, hoarding, social withdrawal, and lack of concern and shame for the individual's residential situation. This paper describes TD who was unable to identify emotional expressions of disgust and was borderline-impaired for facial recognition associated with perceptual difficulties. Problems interpreting expressions of disgust were interesting as TD was living in squalor, neglecting himself, and lacked concern for his circumstances...
November 6, 2017: Neuropsychological Rehabilitation
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