keyword
https://read.qxmd.com/read/38491957/somatic-variants-as-a-cause-of-drug-resistant-epilepsy-including-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#1
JOURNAL ARTICLE
Robert J Carton, Michael G Doyle, Hugh Kearney, Charles A Steward, Nicholas J Lench, Anthony Rogers, Erin L Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El-Naggar, Peter Widdess-Walsh, Daniel Costello, Ronan Kilbride, Colin P Doherty, Kieron J Sweeney, Donncha F O'Brien, David C Henshall, Norman Delanty, Gianpiero L Cavalleri, Katherine A Benson
OBJECTIVE: The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. METHODS: Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38485508/changes-in-structural-plasticity-of-hippocampal-neurons-in-an-animal-model-of-multiple-sclerosis
#2
JOURNAL ARTICLE
Poornima D E Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Sung-Ho Kim, Hongbing Wang, Taekyun Shin, Changjong Moon
Structural plasticity is critical for the functional diversity of neurons in the brain. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for multiple sclerosis (MS), successfully mimicking its key pathological features (inflammation, demyelination, axonal loss, and gliosis) and clinical symptoms (motor and non-motor dysfunctions). Recent studies have demonstrated the importance of synaptic plasticity in EAE pathogenesis. In the present study, we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase (11 days post-immunization, DPI) and chronic phase (28 DPI)...
March 18, 2024: Zoological Research
https://read.qxmd.com/read/38478792/association-of-age-related-neuropathologic-findings-at-autopsy-with-a-claims-based-epilepsy-diagnosis-in-older-adults
#3
JOURNAL ARTICLE
Shahram Oveisgharan, Francine Grodstein, Arnold M Evia, Bryan D James, Ana W Capuano, Yi Chen, Konstantinos Arfanakis, Julie A Schneider, David A Bennett
BACKGROUND AND OBJECTIVES: Epilepsy is 1 of the 3 most common neurologic diseases of older adults, but few studies have examined its underlying pathologies in older age. We examined the associations of age-related brain pathologies with epilepsy in older persons. METHODS: Clinical and pathologic data came from 2 ongoing clinical pathologic cohort studies of community-dwelling older adults. Epilepsy was ascertained using Medicare fee-for-service Parts A and B claims data that were linked to data from the cohort studies...
April 9, 2024: Neurology
https://read.qxmd.com/read/38467626/identification-of-gene-regulatory-networks-affected-across-drug-resistant-epilepsies
#4
JOURNAL ARTICLE
Liesbeth François, Alessia Romagnolo, Mark J Luinenburg, Jasper J Anink, Patrice Godard, Marek Rajman, Jonathan van Eyll, Angelika Mühlebner, Andrew Skelton, James D Mills, Stefanie Dedeurwaerdere, Eleonora Aronica
Epilepsy is a chronic and heterogenous disease characterized by recurrent unprovoked seizures, that are commonly resistant to antiseizure medications. This study applies a transcriptome network-based approach across epilepsies aiming to improve understanding of molecular disease pathobiology, recognize affected biological mechanisms and apply causal reasoning to identify therapeutic hypotheses. This study included the most common drug-resistant epilepsies (DREs), such as temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), and mTOR pathway-related malformations of cortical development (mTORopathies)...
March 11, 2024: Nature Communications
https://read.qxmd.com/read/38447234/expression-and-correlation-of-the-nod-like-receptor-family-pyrin-domain-containing-3-inflammasome-and-the-silent-information-regulator-1-in-patients-with-drug-resistant-epilepsy
#5
JOURNAL ARTICLE
Qing Li, Zhenzhen Qu, Lijing Jia, Weiping Wang
BACKGROUND: The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammatory pathway is implicated in the development of epilepsy and can be suppressed by the activation of the silent information regulator 1 (SIRT1). However, the expression and correlation of the NLRP3 pathway and SIRT1 in drug-resistant epilepsy (DRE) remain unknown. METHODS: This study evaluated the histopathology of the cerebral cortex from nine patients with DRE and eight patients with cavernous haemangioma undergoing surgical treatment...
March 2, 2024: Epilepsy Research
https://read.qxmd.com/read/38442416/postsurgical-outcomes-of-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-associated-with-calcified-neurocysticercosis
#6
JOURNAL ARTICLE
Walter De la Cruz, Sofía S Sánchez-Boluarte, Denisse E Chacón, Manuel Herrera, Liza Núñez Del Prado, Carlos M Vásquez, José C Delgado
The aim of this study was to analyze postsurgical outcomes for individuals with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) who underwent anterior temporal lobectomy, based on the presence of calcified neurocysticercosis (cNCC). A retrospective cross-sectional study was conducted on 89 patients with MTLE-HS who underwent anterior temporal lobectomy between January 2012 and December 2020 at a basic epilepsy surgery center located in Lima, Peru. We collected sociodemographic, clinical, and diagnostic information...
March 5, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38436479/evidence-for-interictal-blood-brain-barrier-dysfunction-in-people-with-epilepsy
#7
JOURNAL ARTICLE
Johannes T Reiter, Freya Schulte, Tobias Bauer, Bastian David, Christoph Endler, Alexander Isaak, Fabiane Schuch, Felix Bitzer, Juri-Alexander Witt, Elke Hattingen, Ralf Deichmann, Ulrike Attenberger, Albert J Becker, Christoph Helmstaedter, Alexander Radbruch, Rainer Surges, Alon Friedman, Theodor Rüber
OBJECTIVE: Interictal blood-brain barrier dysfunction in chronic epilepsy has been demonstrated in animal models and pathological specimens. Ictal blood-brain barrier dysfunction has been shown in humans in vivo using an experimental quantitative magnetic resonance imaging (MRI) protocol. Here, we hypothesized that interictal blood-brain barrier dysfunction is also present in people with drug-resistant epilepsy. METHODS: Thirty-nine people (21 females, mean age at MRI ± SD = 30 ± 8 years) with drug-resistant epilepsy were prospectively recruited and underwent interictal T1-relaxometry before and after administration of a paramagnetic contrast agent...
March 4, 2024: Epilepsia
https://read.qxmd.com/read/38436259/deciphering-the-association-of-epstein-barr-virus-and-its-glycoprotein-m-peptide-with-neuropathologies-in-mice
#8
JOURNAL ARTICLE
Annu Rani, Priyanka Patra, Tarun Prakash Verma, Anamika Singh, Ajay Kumar Jain, Neha Jaiswal, Sanjeev Narang, Nitish Mittal, Hamendra Singh Parmar, Hem Chandra Jha
The reactivation of ubiquitously present Epstein-Barr virus (EBV) is known to be involved with numerous diseases, including neurological ailments. A recent in vitro study from our group unveiled the association of EBV and its 12-amino acid peptide glycoprotein M146-157 (gM146-157 ) with neurodegenerative diseases, viz., Alzheimer's disease (AD) and multiple sclerosis. In this study, we have further validated this association at the in vivo level. The exposure of EBV/gM146-157 to mice causes a decline in the cognitive ability with a concomitant increase in anxiety-like symptoms through behavioral assays...
March 4, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38420750/grading-system-for-assessing-the-confidence-in-the-epileptogenic-zone-reported-in-published-studies-a-delphi-consensus-study
#9
JOURNAL ARTICLE
Philippe Ryvlin, Carmen Barba, Fabrice Bartolomei, Christoph Baumgartner, Milan Brazdil, Daniel Fabo, Firas Fahoum, Birgit Frauscher, Akio Ikeda, Samden Lhatoo, Jayanti Mani, Aileen McGonigal, Eeva-Liisa Metsahonkala, Ioana Mindruta, Dang Khoa Nguyen, Sylvain Rheims, Rodrigo Rocamora, Bertil Rydenhag, Stephan Schuele, Andreas Schulze-Bonhage, Rainer Surges, Serge Vulliemoz, Sandor Beniczky
OBJECTIVE: This study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in the localization of the epileptogenic zone (EZ) as reported in published studies, to harmonize and facilitate systematic reviews in the field of epilepsy surgery. METHODS: We conducted a Delphi study involving 22 experts from 18 countries, who were asked to rate their level of confidence in the localization of the EZ for various theoretical clinical scenarios, using different scales...
February 29, 2024: Epilepsia
https://read.qxmd.com/read/38419734/prosopagnosia-face-blindness-and-its-association-with-neurological-disorders
#10
JOURNAL ARTICLE
Kennedy A Josephs, Keith A Josephs
Loss of facial recognition or prosopagnosia has been well-recognized for over a century. It has been categorized as developmental or acquired depending on whether the onset is in early childhood or beyond, and acquired cases can have degenerative or non-degenerative aetiologies. Prosopagnosia has been linked to involvement of the fusiform gyri, mainly in the right hemisphere. The literature on prosopagnosia comprises case reports and small case series. We aim to assess demographic, clinical and imaging characteristics and neurological and neuropathological disorders associated with a diagnosis of prosopagnosia in a large cohort...
2024: Brain communications
https://read.qxmd.com/read/38418170/-differentiation-of-temporal-lobe-epilepsy-and-temporal-plus-epilepsy-using-radiomics-nomogram-based-on-mprage-images
#11
RANDOMIZED CONTROLLED TRIAL
X M Yan, F Z Yin, T Yu, X H Zhang, X Zhang, C P Xu, X X Zhou
A total of 82 patients with temporal lobe epilepsy (TLE) and temporal plus epilepsy (TPE)admitted in Xuanwu Hospital from January 1, 2019, to January 1, 2021 were restrospectively analyzed, including 41 males and 41 females, aged 2 to 52 (24±10) years. The patients were randomly divided into the training set (58 cases) and test set (24 cases) by Python. FreeSurfer software was used to segment the cortex of the affected hemisphere, defining 33 regions of interest (ROIs), and radiomics features were extracted by Python...
March 5, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38411286/patterns-of-subregional-cerebellar-atrophy-across-epilepsy-syndromes-an-enigma-epilepsy-study
#12
JOURNAL ARTICLE
Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
February 27, 2024: Epilepsia
https://read.qxmd.com/read/38404827/analysis-of-the-role-of-panoptosis-in-seizures-via-integrated-bioinformatics-analysis-and-experimental-validation
#13
JOURNAL ARTICLE
Yueying Liu, Yuanjin Chang, Xiaofan Jiang, Huiya Mei, Yingsi Cao, Dongqin Wu, Ruijin Xie, Wenjun Jiang, Emely Vasquez, Yu Wu, Shunyan Lin, Yachuan Cao
BACKGROUND: Epilepsy is recognized as the most common chronic neurological condition among children, and hippocampal neuronal cell death has been identified as a crucial factor in the pathophysiological processes underlying seizures. In recent studies, PANoptosis, a newly characterized form of cell death, has emerged as a significant contributor to the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. PANoptosis involves the simultaneous activation of pyroptosis, apoptosis, and necroptosis within the same population of cells...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38395110/the-dose-dependent-neuroprotective-effect-of-norepinephrine-in-improving-memory-retrieval-in-an-experimental-model-of-multiple-sclerosis-experimental-autoimmune-encephalomyelitis
#14
JOURNAL ARTICLE
Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Vida Hojjati, Faezeh Ghorbani-Taherdehi, Amirhossein Sahebkar, Mahmoud Gorji-Valokola
Multiple sclerosis (MS) is considered an immune-mediated inflammatory disorder that causes cognitive impairments by damaging the hippocampal tissue. Conversely, norepinephrine (NEP) has anti-inflammatory and re-myelinating properties, which improve cognitive impairments. The aim of this study was to assess the neuroprotective effects of NEP on learning and memory disorders in an experimental animal model of MS. Two guide cannulas were bilaterally implanted in the rat hippocampal CA1 regions. After recovery, the animals received 3μl of 0...
February 21, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38383054/radiologic-classification-of-hippocampal-sclerosis-in-epilepsy
#15
REVIEW
Erik H Middlebrooks, Vivek Gupta, Amit K Agarwal, Brin E Freund, Steven A Messina, William O Tatum, David S Sabsevitz, Anteneh M Feyissa, Seyed M Mirsattari, Fernando N Galan, Alfredo Quinones-Hinojosa, Sanjeet S Grewal, John V Murray
Temporal lobe epilepsy is a common form of epilepsy that is often associated with hippocampal sclerosis (HS). Although HS is commonly considered a binary assessment in radiological evaluation, it is known that histopathological changes occur in distinct clusters. Some subtypes of HS only affect certain subfields, resulting in minimal changes to the overall volume of the hippocampus. This is likely a major reason why whole hippocampal volumetrics have underperformed versus expert readers. With recent advancements in MRI technology, it is now possible to characterize the substructure of the hippocampus more accurately...
February 21, 2024: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/38382810/current-advances-in-rodent-drug-resistant-temporal-lobe-epilepsy-models-hints-from-laboratory-studies
#16
REVIEW
Shuo Zhang, Shengyang Xie, Yang Zheng, Zhong Chen, Cenglin Xu
Anti-seizure drugs (ASDs) are the first choice for the treatment of epilepsy, but there is still one-third of patients with epilepsy (PWEs) who are resistant to two or more appropriately chosen ASDs, named drug-resistant epilepsy (DRE). Temporal lobe epilepsy (TLE), a common type of epilepsy usually associated with hippocampal sclerosis (HS), shares the highest proportion of drug resistance (approximately 70%). In view of the key role of the temporal lobe in memory, emotion, and other physiological functions, patients with drug-resistant temporal lobe epilepsy (DR-TLE) are often accompanied by serious complications, and surgical procedures also yield extra considerations...
February 19, 2024: Neurochemistry International
https://read.qxmd.com/read/38382495/glucose-metabolism-of-hippocampal-subfields-in-medial-temporal-lobe-epilepsy
#17
JOURNAL ARTICLE
Tse-Hao Lee, Yen-Cheng Shih, Yi-Jiun Lu, Chien-Chen Chou, Cheng-Chia Lee, Hsiang-Yu Yu, Syu-Jyun Peng
PURPOSE: Reduced glucose metabolism in the hippocampus is commonly observed in cases of medial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS). Glucose metabolism among the various hippocampal subfields has not been thoroughly investigated. PATIENTS AND METHODS: This study examined 29 patients (18 females; 15-58 years) diagnosed with HS who underwent surgery for drug-resistant epilepsy. FreeSurfer 7.1.1 was used in the processing of MRI data and 18F-FDG PET scans to derive volumetric data and the FDG SUVr in the whole hippocampus and hippocampal subfields, including the CA1, CA2-4, granule cell and molecular layer of the dentate gyrus (GC-ML-DG), and subiculum...
February 23, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38361717/posterior-reversible-encephalopathy-syndrome-pres-and-the-uncommon-sequela-mesial-temporal-sclerosis
#18
Abraham Mengstu, Mathew N Chakko, Blake Salisbury, Jibran Fateh
Posterior reversible encephalopathy syndrome is often linked to conditions like hypertension and is characterized by reversible brain edema. The development of mesial temporal sclerosis as a consequence of posterior reversible encephalopathy syndrome is an uncommon clinical outcome.  We report a 48-year-old female who initially presented with severe iron deficiency anemia, hypertension, and septic tenosynovitis requiring surgical drainage with subsequent development of posterior reversible encephalopathy syndrome accompanied by endocarditis...
January 2024: Curēus
https://read.qxmd.com/read/38357315/the-role-of-cranial-magnetic-resonance-imaging-findings-in-pediatric-epilepsy-a-single-center-experience
#19
JOURNAL ARTICLE
Ozge Yapici, Tugce Aksu Uzunhan
OBJECTIVE: The aim of this study was to investigate cranial magnetic resonance imaging (MRI) findings in different age groups and genders in pediatric epilepsy, to determine the percentages of etiologic factors, and to evaluate the association between MRI positivity and treatment resistance. METHODS: Cranial MRIs of 359 patients with epilepsy aged 1 month to 18 years were retrospectively evaluated. Etiologic factors as an underlying cause of epilepsy were classified as previous parenchymal damage, hippocampal sclerosis, malformations of cortical development, tumor, neurocutaneous syndrome, myelination disorder, vascular anomaly, metabolic/genetic/neurodegenerative diseases, encephalitis, and an uncategorized "other" group...
2024: Northern Clinics of Istanbul
https://read.qxmd.com/read/38355427/mass-spectrometric-imaging-of-anionic-phospholipids-desorbed-from-human-hippocampal-sections-discrimination-between-temporal-and-nontemporal-lobe-epilepsies
#20
JOURNAL ARTICLE
Supratim Mondal, Abhijit Nandy, Geetha Dande, Krishna Prabhu, Rajesh Ramanna Valmiki, Debasish Koner, Shibdas Banerjee
Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, often accompanied by hippocampal sclerosis. The molecular processes underlying this epileptogenesis are poorly understood. To examine the lipid profile, 39 fresh frozen sections of the human hippocampus obtained from epilepsy surgery for TLE ( n = 14) and non-TLE (control group; n = 25) patients were subjected to desorption electrospray ionization mass spectrometry imaging in the negative ion mode. In contrast to our earlier report that showed striking downregulation of positively charged phospholipids ( e...
February 14, 2024: ACS Chemical Neuroscience
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