Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
February 27, 2024: Epilepsia