Kenta Kurayoshi, Yusuke Takase, Masaya Ueno, Kumiko Ohta, Kyoko Fuse, Shuji Ikeda, Takayoshi Watanabe, Yuki Nishida, Shin-Ichi Horike, Kazuyoshi Hosomichi, Yuichi Ishikawa, Yuko Tadokoro, Masahiko Kobayashi, Atsuko Kasahara, Yongwei Jing, Mahmoud I Shoulkamy, Makiko Meguro-Horike, Kensuke Kojima, Hitoshi Kiyoi, Hiroshi Sugiyama, Hiroki Nagase, Atsushi Tajima, Atsushi Hirao
Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more versatile methodologies that are applicable to a wide range of AML subtypes is desired. Although the FOXOs transcription factor represents a promising drug target for differentiation therapy, the efficacy of FOXO inhibitors is limited in vivo. Here, we show that pharmacological inhibition of a common cis-regulatory element of forkhead box O (FOXO) family members successfully induced cell differentiation in various AML cell lines...
September 29, 2023: Cell Death & Disease