Lin Shi, Lei Zhao, Fu Ki Yeung, Shun Yiu Wong, Ronald K T Chan, Ming Fai Tse, Sze Chun Chan, Yee Ching Kwong, Ka Chun Li, Kai Liu, Jill M Abrigo, Alexander Y L Lau, Adrian Wong, Bonnie Y K Lam, Thomas W H Leung, Jianhui Fu, Winnie C W Chu, Vincent C T Mok
OBJECTIVES: Individual neuroimaging features of small vessel disease (SVD) have been reported to influence poststroke cognition. This study aimed to investigate the joint contribution and strategic distribution patterns of multiple types of SVD imaging features in poststroke cognitive impairment. METHODS: We studied 145 first-ever ischaemic stroke patients with MRI and Montreal Cognitive Assessment (MoCA) examined at baseline. The local burdens of acute ischaemic lesion (AIL), white matter hyperintensity, lacune, enlarged perivascular space and cross-sectional atrophy were quantified and entered into support vector regression (SVR) models to associate with the global and domain scores of MoCA...
April 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry