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https://www.readbyqxmd.com/read/28101397/statistical-parametric-mapping-of-stimuli-evoked-changes-in-total-blood-flow-velocity-in-the-mouse-cortex-obtained-with-extended-focus-optical-coherence-microscopy
#1
Paul J Marchand, Arno Bouwens, Tristan Bolmont, Vincent K Shamaei, David Nguyen, Daniel Szlag, Jérôme Extermann, Theo Lasser
Functional magnetic resonance (fMRI) imaging is the current gold-standard in neuroimaging. fMRI exploits local changes in blood oxygenation to map neuronal activity over the entire brain. However, its spatial resolution is currently limited to a few hundreds of microns. Here we use extended-focus optical coherence microscopy (xfOCM) to quantitatively measure changes in blood flow velocity during functional hyperaemia at high spatio-temporal resolution in the somatosensory cortex of mice. As optical coherence microscopy acquires hundreds of depth slices simultaneously, blood flow velocity measurements can be performed over several vessels in parallel...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28092511/the-concept-of-effective-inflow-application-to-interictal-localization-of-the-epileptogenic-focus-from-ieeg
#2
Ioannis Vlachos, Balu Krishnan, David Treiman, Konstantinos Tsakalis, Dimitris Kugiumtzis, Leon D Iasemidis
GOAL: Accurate determination of the epileptogenic focus is of paramount diagnostic and therapeutic importance in epilepsy. The current gold standard for focus localization is from ictal (seizure) onset and thus requires the occurrence and recording of multiple typical seizures of a patient. Localization of the focus from seizure-free (interictal) periods remains a challenging problem, especially in the absence of interictal epileptiform activity. METHODS: By exploring the concept of effective inflow, we developed a focus localization algorithm (FLA) based on directed connectivity between brain sites...
November 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28055223/claim-assessment-profile-a-method-for-capturing-healthcare-evidence-in-the-scientific-evaluation-and-review-of-claims-in-health-care-search
#3
Lara Hilton, Wayne B Jonas
BACKGROUND: Grounding health claims in an evidence base is essential for determining safety and effectiveness. However, it is not appropriate to evaluate all healthcare claims with the same methods. "Gold standard" randomized controlled trials may skip over important qualitative and observational data about use, benefits, side effects, and preferences, issues especially salient in research on complementary and integrative health (CIH) practices. This gap has prompted a move toward studying treatments in their naturalistic settings...
January 5, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28046310/th-cd-206-02-best-in-physics-imaging-3d-prostate-segmentation-in-mr-images-using-patch-based-anatomical-signature
#4
X Yang, A Jani, P Rossi, H Mao, W Curran, T Liu
PURPOSE: MRI has shown promise in identifying prostate tumors with high sensitivity and specificity for the detection of prostate cancer. Accurate segmentation of the prostate plays a key role various tasks: to accurately localize prostate boundaries for biopsy needle placement and radiotherapy, to initialize multi-modal registration algorithms or to obtain the region of interest for computer-aided detection of prostate cancer. However, manual segmentation during biopsy or radiation therapy can be time consuming and subject to inter- and intra-observer variation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042815/concept-and-development-of-an-electronic-framework-intended-for-electrode-and-surrounding-environment-characterization-in-vivo
#5
Stefan B Rieger, Jennifer Pfau, Thomas Stieglitz, Maria Asplund, Juan S Ordonez
There has been substantial progress over the last decade towards miniaturizing implantable microelectrodes for use in Active Implantable Medical Devices (AIMD). Compared to the rapid development and complexity of electrode miniaturization, methods to monitor and assess functional integrity and electrical functionality of these electrodes, particularly during long term stimulation, have not progressed to the same extent. Evaluation methods that form the gold standard, such as stimulus pulse testing, cyclic voltammetry and electrochemical impedance spectroscopy, are either still bound to laboratory infrastructure (impractical for long term in vivo experiments) or deliver no comprehensive insight into the material's behaviour...
December 30, 2016: Sensors
https://www.readbyqxmd.com/read/28040034/automatic-measurement-of-vowel-duration-via-structured-prediction
#6
Yossi Adi, Joseph Keshet, Emily Cibelli, Erin Gustafson, Cynthia Clopper, Matthew Goldrick
A key barrier to making phonetic studies scalable and replicable is the need to rely on subjective, manual annotation. To help meet this challenge, a machine learning algorithm was developed for automatic measurement of a widely used phonetic measure: vowel duration. Manually-annotated data were used to train a model that takes as input an arbitrary length segment of the acoustic signal containing a single vowel that is preceded and followed by consonants and outputs the duration of the vowel. The model is based on the structured prediction framework...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28034638/free-breathing-whole-heart-3d-cine-mri-with-self-gated-cartesian-trajectory
#7
M Usman, B Ruijsink, M S Nazir, G Cruz, C Prieto
PURPOSE: To present a method that uses a novel free-running self-gated acquisition to achieve isotropic resolution in whole heart 3D Cartesian cardiac CINE MRI. MATERIAL AND METHODS: 3D cardiac CINE MRI using navigator gating results in long acquisition times. Recently, several frameworks based on self-gated non-Cartesian trajectories have been proposed to accelerate this acquisition. However, non-Cartesian reconstructions are computationally expensive due to gridding, particularly in 3D...
December 26, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28011418/compose-using-temporal-patterns-for-interpreting-wearable-sensor-data-with-computer-interpretable-guidelines
#8
V Urovi, O Jimenez-Del-Toro, F Dubosson, A Ruiz Torres, M I Schumacher
This paper describes a novel temporal logic-based framework for reasoning with continuous data collected from wearable sensors. The work is motivated by the Metabolic Syndrome, a cluster of conditions which are linked to obesity and unhealthy lifestyle. We assume that, by interpreting the physiological parameters of continuous monitoring, we can identify which patients have a higher risk of Metabolic Syndrome. We define temporal patterns for reasoning with continuous data and specify the coordination mechanisms for combining different sets of clinical guidelines that relate to this condition...
December 5, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27992323/the-concept-of-effective-inflow-application-to-interictal-localization-of-the-epileptogenic-focus-from-ieeg
#9
Ioannis Vlachos, Balu Krishnan, David Treiman, Konstantinos Tsakalis, Dimitris Kugiumtzis, Leon D Iasemidis
GOAL: Accurate determination of the epileptogenic focus is of paramount diagnostic and therapeutic importance in epilepsy. The current gold standard for focus localization is from ictal (seizure) onset and thus requires the occurrence and recording of multiple typical seizures of a patient. Localization of the focus from seizure-free (interictal) periods remains a challenging problem, especially in the absence of interictal epileptiform activity. METHODS: By exploring the concept of effective inflow, we developed a focus localization algorithm (FLA) based on directed connectivity between brain sites...
November 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27935799/strengthening-health-information-systems-for-disability-related-rehabilitation-in-lmics
#10
Anna McPherson, Jo Durham, Nicola Richards, Hebe Gouda, Rasika Rampatige, Maxine Whittaker
The purpose of this study was to describe the state of rehabilitation health information systems (HIS) in different settings, and identify key processes and actions which contribute to the development of HIS which can effectively support low- and middle-income countries (LMICs) allocate resources to health-related rehabilitation to people with disabilities. Nine case studies were conducted across different disability and developmental settings using documentary review and semi-structured key informant interviews (N = 41)...
October 10, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27932498/harnessing-molecular-motors-for-nanoscale-pulldown-in-live-cells
#11
Jonathan E Bird, Melanie Barzik, Meghan C Drummond, Daniel C Sutton, Spencer M Goodman, Eva L Morozko, Stacey M Cole, Alexandra K Boukhvalova, Jennifer Skidmore, Diana Syam, Elizabeth A Wilson, Tracy Fitzgerald, Atteeq U Rehman, Donna M Martin, Erich T Boger, Inna A Belyantseva, Thomas B Friedman
Protein-protein interactions (PPIs) regulate assembly of macromolecular complexes, yet these remain challenging to study within the native cytoplasm where they normally exert their biological effect. Here, we miniaturize the concept of affinity pulldown, a gold-standard in vitro PPI interrogation technique, to perform nanoscale pulldowns (NanoSPD) within living cells. NanoSPD hijacks the normal process of intracellular trafficking by myosin motors to forcibly pull fluorescently-tagged protein complexes along filopodial actin filaments...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27929744/surveillance-of-poliomyelitis-in-northern-italy-results-of-acute-flaccid-paralysis-surveillance-and-environmental-surveillance-2012-2015
#12
Laura Pellegrinelli, Laura Bubba, Valeria Primache, Elena Pariani, Andrea Battistone, Roberto Delogu, Stefano Fiore, Sandro Binda
Although in the last years poliovirus (PV) transmission has been reported at the lowest levels ever recorded, the spread of virus from endemic countries endures; the high levels of immigration flows across the Mediterranean Sea jeopardize Italy for PV reintroduction. The World Health Organization (WHO) strategic plan for global poliomyelitis (polio) eradication indicates the nationwide surveillance of Acute Flaccid Paralysis (AFP) as the gold standard for detecting cases of polio. In addition, the Environmental Surveillance (ES), seeking the presence of PV and Non-Polio Enterovirus (NPEV) in sewage, is recognized as a powerful tool to confirm PV circulation in absence of AFP cases, especially in polio-free countries...
December 8, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27927161/scifio-an-extensible-framework-to-support-scientific-image-formats
#13
Mark C Hiner, Curtis T Rueden, Kevin W Eliceiri
BACKGROUND: No gold standard exists in the world of scientific image acquisition; a proliferation of instruments each with its own proprietary data format has made out-of-the-box sharing of that data nearly impossible. In the field of light microscopy, the Bio-Formats library was designed to translate such proprietary data formats to a common, open-source schema, enabling sharing and reproduction of scientific results. While Bio-Formats has proved successful for microscopy images, the greater scientific community was lacking a domain-independent framework for format translation...
December 7, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27913320/the-concept-of-effective-inflow-application-to-interictal-localization-of-the-epileptogenic-focus-from-ieeg
#14
Ioannis Vlachos, Balu Krishnan, David Treiman, Konstantinos Tsakalis, Dimitris Kugiumtzis, Leon Iassemidis
GOAL: Accurate determination of the epileptogenic focus is of paramount diagnostic and therapeutic importance in epilepsy. The current gold standard for focus localization is from ictal (seizure) onset and thus requires the occurrence and recording of multiple typical seizures of a patient. Localization of the focus from seizure-free (interictal) periods remains a challenging problem, especially in the absence of interictal epileptiform activity. METHODS: By exploring the concept of effective inflow, we developed a focus localization algorithm (FLA) based on directed connectivity between brain sites...
November 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27911828/evaluating-the-evaluation-of-cancer-driver-genes
#15
Collin J Tokheim, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Rachel Karchin
Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have been developed to identify driver genes, but evaluation of the performance of these methods is hindered by the lack of a gold standard, that is, bona fide driver gene mutations. Here, we establish an evaluation framework that can be applied to driver gene prediction methods. We used this framework to compare the performance of eight such methods. One of these methods, described here, incorporated a machine-learning-based ratiometric approach...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27897779/gold-award-for-prison-health-team
#16
(no author information available yet)
A team from HM Prison Norwich has received the Gold Standards Framework Quality Hallmark Award - the first national recognition of care provided to prisoners in the final months of their lives.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27843789/real-world-evidence-an-indian-perspective
#17
REVIEW
Amit Dang, B N Vallish
Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real world data (RWD) to generate insight, foresight, and explorative findings on diseases, products, and patient populations. There are varied sources of RWD such as administrative data, large pragmatic trials, registries, electronic health records, and health surveys...
October 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27830464/2d-to-3d-fusion-of-echocardiography-and-cardiac-ct-for-tavr-and-tavi-image-guidance
#18
Azira Khalil, Amir Faisal, Khin Wee Lai, Siew Cheok Ng, Yih Miin Liew
This study proposed a registration framework to fuse 2D echocardiography images of the aortic valve with preoperative cardiac CT volume. The registration facilitates the fusion of CT and echocardiography to aid the diagnosis of aortic valve diseases and provide surgical guidance during transcatheter aortic valve replacement and implantation. The image registration framework consists of two major steps: temporal synchronization and spatial registration. Temporal synchronization allows time stamping of echocardiography time series data to identify frames that are at similar cardiac phase as the CT volume...
November 9, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27802082/a-practice-development-initiative-supporting-care-home-staff-deliver-high-quality-end-of-life-care
#19
Jo Hockley, Julie Kinley
BACKGROUND: The global population is changing with an increasing percentage of the oldest old, many of whom in the UK are looked after in care homes. Care homes now provide care for a fifth of the UK population who die each year. However, most nursing care homes are privately owned and not part of the NHS, which exposes staff to a lack of skills/knowledge in relation to end-of-life care. METHODS: To implement the Gold Standards Framework in Care Homes Programme and audit outcomes within nursing care homes across five Clinical Commissioning Groups over a 7-year period using a research-based model of facilitation...
October 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27792722/high-accuracy-hla-type-inference-from-whole-genome-sequencing-data-using-population-reference-graphs
#20
Alexander T Dilthey, Pierre-Antoine Gourraud, Alexander J Mentzer, Nezih Cereb, Zamin Iqbal, Gil McVean
Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many autoimmune and infectious disease phenotypes, is an important element of the immunological distinction between self and non-self, and shapes immune epitope repertoires. Determining the allelic state of the HLA genes (HLA typing) as a by-product of standard whole-genome sequencing data would therefore be highly desirable and enable the immunogenetic characterization of samples in currently ongoing population sequencing projects...
October 2016: PLoS Computational Biology
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