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https://www.readbyqxmd.com/read/29457926/the-contribution-of-theory-to-the-design-delivery-and-evaluation-of-interprofessional-curricula-beme-guide-no-49
#1
Sarah Hean, Christopher Green, Elizabeth Anderson, Debra Morris, Carol John, Richard Pitt, Cath O'Halloran
BACKGROUND: Interprofessional curricula have often lacked explicit reference to theory despite calls for a more theoretically informed field that illuminates curricular assumptions and justifies curricular practices. AIM: To review the contributions of theory to the design, delivery, and evaluation of interprofessional curricula. METHODS: Four databases were searched (1988-2015). Studies demonstrating explicit and a high-quality contribution of theory to the design, delivery or evaluation of interprofessional curricula were included...
February 19, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29437862/structure-and-functions-of-pediatric-aerodigestive-programs-a-consensus-statement
#2
R Paul Boesch, Karthik Balakrishnan, Sari Acra, Dan T Benscoter, Shelagh A Cofer, Joseph M Collaco, John P Dahl, Cori L Daines, Alessandro DeAlarcon, Emily M DeBoer, Robin R Deterding, Joel A Friedlander, Benjamin D Gold, Rayna M Grothe, Catherine K Hart, Mikhail Kazachkov, Maureen A Lefton-Greif, Claire Kane Miller, Paul E Moore, Scott Pentiuk, Stacey Peterson-Carmichael, Joseph Piccione, Jeremy D Prager, Philip E Putnam, Rachel Rosen, Michael J Rutter, Matthew J Ryan, Margaret L Skinner, Cherie Torres-Silva, Christopher T Wootten, Karen B Zur, Robin T Cotton, Robert E Wood
Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well as national meetings, interest groups and early research activity, there is, as of yet, no consensus definition of an aerodigestive patient, standardized structure, and functions of an aerodigestive program or a blueprint for research prioritization. The Delphi method was used by a multidisciplinary and multi-institutional panel of aerodigestive providers to obtain consensus on 4 broad content areas related to aerodigestive care: (1) definition of an aerodigestive patient, (2) essential construct and functions of an aerodigestive program, (3) identification of aerodigestive research priorities, and (4) evaluation and recognition of aerodigestive programs and future directions...
February 7, 2018: Pediatrics
https://www.readbyqxmd.com/read/29414561/a-modern-epilepsy-surgery-treatment-algorithm-incorporating-traditional-and-emerging-technologies
#3
REVIEW
Dario J Englot
Epilepsy surgery has seen numerous technological advances in both diagnostic and therapeutic procedures in recent years. This has increased the number of patients who may be candidates for intervention and potential improvement in quality of life. However, the expansion of the field also necessitates a broader understanding of how to incorporate both traditional and emerging technologies into the care provided at comprehensive epilepsy centers. This review summarizes both old and new surgical procedures in epilepsy using an example algorithm...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29402268/true-malaria-prevalence-in-children-under-five-bayesian-estimation-using-data-of-malaria-household-surveys-from-three-sub-saharan-countries
#4
Elvire Mfueni, Brecht Devleesschauwer, Angel Rosas-Aguirre, Carine Van Malderen, Patrick T Brandt, Bernhards Ogutu, Robert W Snow, Léon Tshilolo, Dejan Zurovac, Dieter Vanderelst, Niko Speybroeck
BACKGROUND: Malaria is one of the major causes of childhood death in sub-Saharan countries. A reliable estimation of malaria prevalence is important to guide and monitor progress toward control and elimination. The aim of the study was to estimate the true prevalence of malaria in children under five in the Democratic Republic of the Congo, Uganda and Kenya, using a Bayesian modelling framework that combined in a novel way malaria data from national household surveys with external information about the sensitivity and specificity of the malaria diagnostic methods used in those surveys-i...
February 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29402104/developing-an-intervention-for-optimizing-end-of-life-care-in-any-setting
#5
Emily Dobson
The gold standards of care created within the hospice setting are not always effectively influencing national, regional or local policy. This struggle is something which the public health sector has successfully contended with. In particular an approach known as Health in All Policies (HiAP) has been developed to lay down the rules of engagement and guide the exchange between organisations from all sectors. This synergy allows for an exploration of the possibilities of utilising HiAP within end of life care...
January 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29382321/inferring-synteny-between-genome-assemblies-a-systematic-evaluation
#6
Dang Liu, Martin Hunt, Isheng J Tsai
BACKGROUND: Genome assemblies across all domains of life are being produced routinely. Initial analysis of a new genome usually includes annotation and comparative genomics. Synteny provides a framework in which conservation of homologous genes and gene order is identified between genomes of different species. The availability of human and mouse genomes paved the way for algorithm development in large-scale synteny mapping, which eventually became an integral part of comparative genomics...
January 30, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29373993/a-hybrid-type-i-trial-to-increase-veterans-access-to-insomnia-care-study-protocol-for-a-randomized-controlled-trial
#7
Adam D Bramoweth, Anne Germain, Ada O Youk, Keri L Rodriguez, Matthew J Chinman
BACKGROUND: Chronic insomnia is among the most reported complaints of Veterans and military personnel referred for mental health services. It is highly comorbid with medical and psychiatric disorders, and is associated with significantly increased healthcare utilization and costs. Evidence-based psychotherapy, namely Cognitive Behavioral Therapy for Insomnia (CBTI), is an effective treatment and recommended over prescription sleep medications. While CBTI is part of a nationwide rollout in the Veterans Health Administration to train hundreds of providers, access to treatment is still limited for many Veterans due to limited treatment availability, low patient and provider knowledge about treatment options, and Veteran barriers such as distance and travel, work schedules, and childcare...
January 26, 2018: Trials
https://www.readbyqxmd.com/read/29351650/are-evidence-based-community-engaged-energy-balance-interventions-enough-for-extremely-vulnerable-populations
#8
Nancy E Schoenberg, Yelena N Tarasenko, Claire Snell-Rood
Well-documented associations between lifestyle behaviors and disease outcomes necessitate evidence-based health promotion interventions. To enhance potential efficacy and effectiveness, interventionists increasingly respond to community priorities, employ comprehensive theoretical frameworks, invest heavily to ensure cultural fit, implement evidence-based programming, and deploy research gold standards. We describe a project that followed all of these recommended strategies, but did not achieve desired outcomes...
January 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29349931/biomimetic-architectures-for-peripheral-nerve-repair-a-review-of-biofabrication-strategies
#9
REVIEW
Paul A Wieringa, Ana Rita Gonçalves de Pinho, Silvestro Micera, Richard J A van Wezel, Lorenzo Moroni
Biofabrication techniques have endeavored to improve the regeneration of the peripheral nervous system (PNS), but nothing has surpassed the performance of current clinical practices. However, these current approaches have intrinsic limitations that compromise patient care. The "gold standard" autograft provides the best outcomes but requires suitable donor material, while implantable hollow nerve guide conduits (NGCs) can only repair small nerve defects. This review places emphasis on approaches that create structural cues within a hollow NGC lumen in order to match or exceed the regenerative performance of the autograft...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29345009/choosing-non-redundant-representative-subsets-of-protein-sequence-data-sets-using-submodular-optimization
#10
Maxwell W Libbrecht, Jeffrey A Bilmes, William Stafford Noble
Selecting a non-redundant representative subset of sequences is a common step in many bioinformatics workflows, such as the creation of non-redundant training sets for sequence and structural models or selection of "operational taxonomic units" from metagenomics data. Previous methods for this task, such as CD-HIT, PISCES and UCLUST, apply a heuristic threshold-based algorithm that has no theoretical guarantees. We propose a new approach based on submodular optimization. Submodular optimization, a discrete analogue to continuous convex optimization, has been used with great success for other representative set selection problems...
January 18, 2018: Proteins
https://www.readbyqxmd.com/read/29339507/large-scale-comparative-epigenomics-reveals-hierarchical-regulation-of-non-cg-methylation-in-arabidopsis
#11
Yu Zhang, C Jake Harris, Qikun Liu, Wanlu Liu, Israel Ausin, Yanping Long, Lidan Xiao, Li Feng, Xu Chen, Yubin Xie, Xinyuan Chen, Lingyu Zhan, Suhua Feng, Jingyi Jessica Li, Haifeng Wang, Jixian Zhai, Steven E Jacobsen
Genome-wide characterization by next-generation sequencing has greatly improved our understanding of the landscape of epigenetic modifications. Since 2008, whole-genome bisulfite sequencing (WGBS) has become the gold standard for DNA methylation analysis, and a tremendous amount of WGBS data has been generated by the research community. However, the systematic comparison of DNA methylation profiles to identify regulatory mechanisms has yet to be fully explored. Here we reprocessed the raw data of over 500 publicly available Arabidopsis WGBS libraries from various mutant backgrounds, tissue types, and stress treatments and also filtered them based on sequencing depth and efficiency of bisulfite conversion...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337276/validation-of-diffusion-mri-estimates-of-compartment-size-and-volume-fraction-in-a-biomimetic-brain-phantom-using-a-human-mri-scanner-with-300%C3%A2-mt-m-maximum-gradient-strength
#12
Qiuyun Fan, Aapo Nummenmaa, Barbara Wichtmann, Thomas Witzel, Choukri Mekkaoui, Walter Schneider, Lawrence L Wald, Susie Y Huang
Diffusion microstructural imaging techniques have attracted great interest in the last decade due to their ability to quantify axon diameter and volume fraction in healthy and diseased human white matter. The estimates of compartment size and volume fraction continue to be debated, in part due to the lack of a gold standard for validation and quality control. In this work, we validate diffusion MRI estimates of compartment size and volume fraction using a novel textile axon ("taxon") phantom constructed from hollow polypropylene yarns with distinct intra- and extra-taxonal compartments to mimic white matter in the brain...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29335033/should-capacity-assessments-be-performed-routinely-prior-to-discussing-advance-care-planning-with-older-people
#13
Oleg Kiriaev, Emme Chacko, J D Jurgens, Meagan Ramages, Phillipa Malpas, Gary Cheung
BACKGROUND: People with dementia receive worse end of life care compared to those with cancer. Barriers to undertaking advanced care planning (ACP) in people with dementia include the uncertainty about their capacity to engage in such discussions. The primary aim of this study was to compare the Advance Care Planning-Capacity Assessment Vignette tool (ACP-CAV) with a semi-structured interview adapted from the MacArthur Competence Assessment Tool-Treatment (MacCAT-T). The secondary aim was to identify demographic and cognitive functioning variables that may predict whether a person has capacity to discuss ACP...
January 16, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29324567/electronic-health-record-implementation-findings-at-a-large-suburban-health-and-human-services-department
#14
Kenyon Crowley, Anubhuti Mishra, Raul Cruz-Cano, Robert Gold, Dushanka Kleinman, Ritu Agarwal
OBJECTIVE: Evaluate an electronic health record (EHR) implementation across a large public health department to better understand and improve implementation effectiveness of EHRs in public health departments. DESIGN: A survey based on Consolidated Framework for Implementation Research constructs was administered to staff before and after implementation of an EHR. SETTING: Large suburban county department of health and human services that provides clinical, behavioral, social, and oral health services...
January 10, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29305018/multilevel-analysis-of-individual-heterogeneity-and-discriminatory-accuracy-maihda-within-an-intersectional-framework
#15
Juan Merlo
BACKGROUND: Analyzing Body Mass Index as a didactical example, the study by Evans, Williams, Onnela, and Subramanian (EWOS study) introduce a novel methodology for the investigation of socioeconomic disparities in health. By using multilevel analysis to model health inequalities within and between strata defined by the intersection of multiple social and demographic dimensions, the authors provide a better understanding of the health heterogeneity existing in the population. Their innovative methodology allows for gathering inductive information on a large number of stratum-specific interactions of effects and, simultaneously, informs on the discriminatory accuracy of such strata for predicting individual health...
December 26, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29297208/method-for-accurate-registration-of-tissue-autofluorescence-imaging-data-with-corresponding-histology-a-means-for-enhanced-tumor-margin-assessment
#16
Jakob Unger, Tianchen Sun, Yi-Ling Chen, Jennifer E Phipps, Richard J Bold, Morgan A Darrow, Kwan-Liu Ma, Laura Marcu
An important step in establishing the diagnostic potential for emerging optical imaging techniques is accurate registration between imaging data and the corresponding tissue histopathology typically used as gold standard in clinical diagnostics. We present a method to precisely register data acquired with a point-scanning spectroscopic imaging technique from fresh surgical tissue specimen blocks with corresponding histological sections. Using a visible aiming beam to augment point-scanning multispectral time-resolved fluorescence spectroscopy on video images, we evaluate two different markers for the registration with histology: fiducial markers using a 405-nm CW laser and the tissue block's outer shape characteristics...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29278842/estimating-the-sensitivity-of-a-prostate-cancer-screening-programme-for-different-psa-cut-off-levels-a-uk-case-study
#17
Jose Leal, Nicky J Welton, Richard M Martin, Jenny Donovan, Freddie Hamdy, David Neal, Sian Noble, Athene Lane, Jane Wolstenholme
INTRODUCTION: Policy decisions about prostate cancer screening require data on the natural history of histological cancers and the resulting impact of screening. However, the gold standard procedure required to identify true positive histological cancer is a full autopsy of the gland which is not possible in screening studies, leading to verification bias. We aim to estimate the sensitivity of a prostate cancer screening round (PSA result to diagnosis) relative to histological cancer...
December 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29261853/metal-free-materials-for-fixed-prosthodontic-restorations
#18
REVIEW
Carlo E Poggio, Carlo Ercoli, Lorena Rispoli, Carlo Maiorana, Marco Esposito
BACKGROUND: Fixed prosthodontic treatment (crowns, fixed dental prostheses (FDPs), complete arch prostheses) involves the use of several different materials to replace missing tooth structure. Traditionally full metal or metal frameworks veneered with ceramic (metal-ceramic (MC)) have been used. In recent years several different metal-free systems have become available to clinicians and patients. In general, metal-free restorations should allow practitioners to better reproduce natural tooth colour, avoiding shortcomings of MC restorations...
December 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29238666/preoperative-counseling-and-expectation-management-for-inflatable-penile-prosthesis-implantation
#19
REVIEW
Gopal L Narang, Bradley D Figler, Robert M Coward
The inflatable penile prosthesis (IPP) is the gold standard surgical treatment for medical refractory erectile dysfunction (ED). While the modern IPP has enjoyed high satisfaction rates as a product of its continued innovation, reliability, and performance, patient dissatisfaction can still occur. IPP implantation restores physiologic function with cosmetic and psychological consequences, both of which place inherent emphasis on preoperative counseling and expectation management. This review aims to highlight the complex nature of such counseling and provide practitioners with a roadmap to navigate the landscape...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29226494/how-does-routinely-delivered-cognitive-behavioural-therapy-for-gambling-disorder-compare-to-gold-standard-clinical-trial
#20
David P Smith, A Kate Fairweather-Schmidt, Peter W Harvey, Malcolm W Battersby
Currently, it is unknown whether treatment outcomes derived from randomized controlled trials (RCTs) of cognitive-behavioural therapy (CBT) for problem gamblers still hold when applied to patients seen in routine practice. Thus, data from an RCT of cognitive therapy versus exposure therapy for problem gambling versus patients of a gambling help service were compared. Assessments of problem gambling severity, psychosocial impairment, and alcohol use were undertaken at baseline and post-treatment and evaluated within a counterfactual framework...
December 11, 2017: Clinical Psychology & Psychotherapy
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