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https://www.readbyqxmd.com/read/29666228/deep-learning-improves-prediction-of-drug-drug-and-drug-food-interactions
#1
Jae Yong Ryu, Hyun Uk Kim, Sang Yup Lee
Drug interactions, including drug-drug interactions (DDIs) and drug-food constituent interactions (DFIs), can trigger unexpected pharmacological effects, including adverse drug events (ADEs), with causal mechanisms often unknown. Several computational methods have been developed to better understand drug interactions, especially for DDIs. However, these methods do not provide sufficient details beyond the chance of DDI occurrence, or require detailed drug information often unavailable for DDI prediction. Here, we report development of a computational framework DeepDDI that uses names of drug-drug or drug-food constituent pairs and their structural information as inputs to accurately generate 86 important DDI types as outputs of human-readable sentences...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29660595/computer-assisted-subtyping-and-prognosis-for-non-small-cell-lung-cancer-patients-with-unresectable-tumor
#2
Maliazurina Saad, Tae-Sun Choi
BACKGROUND: The histological classification or subtyping of non-small cell lung cancer is essential for systematic therapy decisions. Differentiating between the two main subtypes of pulmonary adenocarcinoma and squamous cell carcinoma highlights the considerable differences that exist in the prognosis of patient outcomes. Physicians rely on a pathological analysis to reveal these phenotypic variations that requires invasive methods, such as biopsy and resection sample, but almost 70% of tumors are unresectable at the point of diagnosis...
April 4, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29623539/registration-of-3d-freehand-ultrasound-to-a-bone-model-for-orthopedic-procedures-of-the-forearm
#3
Matija Ciganovic, Firat Ozdemir, Fabien Pean, Philipp Fuernstahl, Christine Tanner, Orcun Goksel
PURPOSE: For guidance of orthopedic surgery, the registration of preoperative images and corresponding surgical plans with the surgical setting can be of great value. Ultrasound (US) is an ideal modality for surgical guidance, as it is non-ionizing, real time, easy to use, and requires minimal (magnetic/radiation) safety limitations. By extracting bone surfaces from 3D freehand US and registering these to preoperative bone models, complementary information from these modalities can be fused and presented in the surgical realm...
April 5, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29622855/prospective-image-quality-analysis-and-control-for-prior-image-based-reconstruction-of-low-dose-ct
#4
Hao Zhang, Grace J Gang, Hao Dang, Marc S Sussman, Cheng Ting Lin, Jeffrey H Siewerdsen, J Webster Stayman
Purpose: Prior-image-based reconstruction (PIBR) is a powerful tool for low-dose CT, however, the nonlinear behavior of such approaches are generally difficult to predict and control. Similarly, traditional image quality metrics do not capture potential biases exhibited in PIBR images. In this work, we identify a new bias metric and construct an analytical framework for prospectively predicting and controlling the relationship between prior image regularization strength and this bias in a reliable and quantitative fashion...
March 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29611715/validation-of-rapid-descriptive-sensory-methods-against-conventional-descriptive-analyses-a-systematic-review
#5
Lorena Andrade de Aguiar, Lauro Melo, Lívia de Lacerda de Oliveira
A major drawback of conventional descriptive profile (CDP) in sensory evaluation is the long time spent in panel training. Rapid descriptive methods (RDM) have increased significantly. Some of them have been compared with CDP for validation. In Health Sciences, systematic reviews (SR) are performed to evaluate validation of diagnostic tests in relation to a gold standard method. SR present a well-defined protocol to summarize research evidence and to evaluate the quality of the studies with determined criteria...
April 3, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29581128/improving-palliative-care-provision-in-primary-care-a-pre-and-post-survey-evaluation-among-patz-groups
#6
Annicka Gm van der Plas, H Roeline W Pasman, Bart Schweitzer, Bregje D Onwuteaka-Philipsen
BACKGROUND: In PaTz (PAlliatieve Thuis Zorg, palliative care at home), modelled after the Gold Standards Framework, GPs and community nurses meet on a regular basis to identify patients with palliative care needs (the PaTz register), and to discuss care for these patients. AIM: To study the effects of the implementation of PaTz, and provide additional analyses on two important elements: the PaTz register and patient discussions. DESIGN AND SETTING: A pre- and post-evaluation among Dutch GPs ( n = 195 before the start of PaTz; n = 166, 1 year after the start of PaTz)...
March 26, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29573591/facilitation-of-an-end-of-life-care-programme-into-practice-within-uk-nursing-care-homes-a-mixed-methods-study
#7
Julie Kinley, Nancy Preston, Katherine Froggatt
BACKGROUND: The predicted demographic changes internationally have implications for the nature of care that older people receive and place of care as they age. Healthcare policy now promotes the implementation of end-of-life care interventions to improve care delivery within different settings. The Gold Standards Framework in Care Homes (GSFCH) programme is one end-of-life care initiative recommended by the English Department of Health. Only a small number of care homes that start the programme complete it, which raises questions about the implementation process...
February 24, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29566525/including-diverging-electrostatic-potential-in-3d-rism-theory-the-charged-wall-case
#8
Ivan Vyalov, Walter Rocchia
Although three-dimensional site-site molecular integral equations of liquids are a powerful tool of the modern theoretical chemistry, their applications to the problem of characterizing the electrical double layer originating at the solid-liquid interface with a macroscopic substrate are severely limited by the fact that an infinitely extended charged plane generates a divergent electrostatic potential. Such potentials cannot be treated within the standard 3D-Reference Interaction Site Model equation solution framework since it leads to functions that are not Fourier transformable...
March 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29556346/non-invasive-electrical-impedance-tomography-for-multi-scale-detection-of-liver-fat-content
#9
Yuan Luo, Parinaz Abiri, Shell Zhang, Chih-Chiang Chang, Amir H Kaboodrangi, Rongsong Li, Ashish K Sahib, Alex Bui, Rajesh Kumar, Mary Woo, Zhaoping Li, René R Sevag Packard, Yu-Chong Tai, Tzung K Hsiai
Introduction: Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). While Magnetic Resonance Imaging (MRI) is a non-invasive gold standard to detect fatty liver, we demonstrate a low-cost and portable electrical impedance tomography (EIT) approach with circumferential abdominal electrodes for liver conductivity measurements. Methods and Results: A finite element model (FEM) was established to simulate decremental liver conductivity in response to incremental liver lipid content...
2018: Theranostics
https://www.readbyqxmd.com/read/29548842/association-measures-of-claims-based-algorithms-for-common-chronic-conditions-were-assessed-using-regularly-collected-data-in-japan
#10
Konan Hara, Jun Tomio, Thomas Svensson, Rika Ohkuma, Akiko Kishi Svensson, Tsutomu Yamazaki
OBJECTIVE: Although claims data are widely used in medical research, their ability to identify persons' health-related conditions has not been fully justified. We assessed the validity of claims-based algorithms (CBAs) for identifying people with common chronic conditions in a large population using annual health screening results as the gold standard. STUDY DESIGN AND SETTING: Using a longitudinal claims database (n=523,267) combined with annual health screening results, we defined the people with hypertension, diabetes, and/or dyslipidemia by applying health screening results as their gold standard, and compared them against various CBAs...
March 13, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29500239/risk-of-12-month-mortality-among-hospital-inpatients-using-the-surprise-question-and-spict-criteria-a-prospective-study
#11
Alison M Mudge, Carol Douglas, Xanthe Sansome, Michael Tresillian, Stephen Murray, Simon Finnigan, Cheryl Ruth Blaber
OBJECTIVES: People with serious life-limiting disease benefit from advance care planning, but require active identification. This study applied the Gold Standards Framework Proactive Identification Guidance (GSF-PIG) to a general hospital population to describe high-risk patients and explore prognostic performance for 12-month mortality. METHODS: Prospective cohort study conducted in a metropolitan teaching hospital in Australia. Hospital inpatients on a single day aged 18 years and older were eligible, excluding maternity and neonatal, mental health and day treatment patients...
March 2, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29498429/understanding-mothers-decision-making-needs-for-autopsy-consent-after-stillbirth-framework-analysis-of-a-large-survey
#12
Anne Schirmann, Frances M Boyle, Dell Horey, Dimitrios Siassakos, David Ellwood, Ingrid Rowlands, Vicki Flenady
BACKGROUND: Experiencing stillbirth is devastating and leaves parents searching for causes. Autopsy is the gold standard for investigation, but deciding to consent to this procedure is very difficult for parents. Decision support in the form of clear, consistent, and parent-centered information is likely to be helpful. The aims of this study were to understand the influences on parents' decisions about autopsy after stillbirth and to identify attributes of effective decision support that align with parents' needs...
March 2, 2018: Birth
https://www.readbyqxmd.com/read/29482617/systematic-comparative-validation-of-self-report-measures-of-sedentary-time-against-an-objective-measure-of-postural-sitting-activpal
#13
S F M Chastin, M L Dontje, D A Skelton, I Čukić, R J Shaw, J M R Gill, C A Greig, C R Gale, I J Deary, G Der, P M Dall
BACKGROUND: Sedentary behaviour is a public health concern that requires surveillance and epidemiological research. For such large scale studies, self-report tools are a pragmatic measurement solution. A large number of self-report tools are currently in use, but few have been validated against an objective measure of sedentary time and there is no comparative information between tools to guide choice or to enable comparison between studies. The aim of this study was to provide a systematic comparison, generalisable to all tools, of the validity of self-report measures of sedentary time against a gold standard sedentary time objective monitor...
February 26, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29482200/structured-review-of-dichotic-tests-of-binaural-integration-clinical-performance-in-children
#14
Kairn Stetler Kelley, Benjamin Littenberg
Purpose: The aim of the study was to evaluate the evidence of clinical utility for dichotic speech tests of binaural integration used to assess auditory processing in English-speaking children 6-14 years old. Method: Dichotic speech test recordings and pertinent research studies were identified from iterative searches of the Internet and bibliographic databases, as well as communication with colleagues and test publishers. Test documentation and peer-reviewed literature were evaluated for evidence of reliability, accuracy, usefulness, and value...
March 8, 2018: American Journal of Audiology
https://www.readbyqxmd.com/read/29466455/a-pneumatic-bionic-voice-prosthesis-pre-clinical-trials-of-controlling-the-voice-onset-and-offset
#15
Farzaneh Ahmadi, Farzad Noorian, Daniel Novakovic, André van Schaik
Despite emergent progress in many fields of bionics, a functional Bionic Voice prosthesis for laryngectomy patients (larynx amputees) has not yet been achieved, leading to a lifetime of vocal disability for these patients. This study introduces a novel framework of Pneumatic Bionic Voice Prostheses as an electronic adaptation of the Pneumatic Artificial Larynx (PAL) device. The PAL is a non-invasive mechanical voice source, driven exclusively by respiration with an exceptionally high voice quality, comparable to the existing gold standard of Tracheoesophageal (TE) voice prosthesis...
2018: PloS One
https://www.readbyqxmd.com/read/29457926/the-contribution-of-theory-to-the-design-delivery-and-evaluation-of-interprofessional-curricula-beme-guide-no-49
#16
Sarah Hean, Christopher Green, Elizabeth Anderson, Debra Morris, Carol John, Richard Pitt, Cath O'Halloran
BACKGROUND: Interprofessional curricula have often lacked explicit reference to theory despite calls for a more theoretically informed field that illuminates curricular assumptions and justifies curricular practices. AIM: To review the contributions of theory to the design, delivery, and evaluation of interprofessional curricula. METHODS: Four databases were searched (1988-2015). Studies demonstrating explicit and a high-quality contribution of theory to the design, delivery or evaluation of interprofessional curricula were included...
February 19, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29437862/structure-and-functions-of-pediatric-aerodigestive-programs-a-consensus-statement
#17
R Paul Boesch, Karthik Balakrishnan, Sari Acra, Dan T Benscoter, Shelagh A Cofer, Joseph M Collaco, John P Dahl, Cori L Daines, Alessandro DeAlarcon, Emily M DeBoer, Robin R Deterding, Joel A Friedlander, Benjamin D Gold, Rayna M Grothe, Catherine K Hart, Mikhail Kazachkov, Maureen A Lefton-Greif, Claire Kane Miller, Paul E Moore, Scott Pentiuk, Stacey Peterson-Carmichael, Joseph Piccione, Jeremy D Prager, Philip E Putnam, Rachel Rosen, Michael J Rutter, Matthew J Ryan, Margaret L Skinner, Cherie Torres-Silva, Christopher T Wootten, Karen B Zur, Robin T Cotton, Robert E Wood
Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well as national meetings, interest groups and early research activity, there is, as of yet, no consensus definition of an aerodigestive patient, standardized structure, and functions of an aerodigestive program or a blueprint for research prioritization. The Delphi method was used by a multidisciplinary and multi-institutional panel of aerodigestive providers to obtain consensus on 4 broad content areas related to aerodigestive care: (1) definition of an aerodigestive patient, (2) essential construct and functions of an aerodigestive program, (3) identification of aerodigestive research priorities, and (4) evaluation and recognition of aerodigestive programs and future directions...
February 7, 2018: Pediatrics
https://www.readbyqxmd.com/read/29414561/a-modern-epilepsy-surgery-treatment-algorithm-incorporating-traditional-and-emerging-technologies
#18
REVIEW
Dario J Englot
Epilepsy surgery has seen numerous technological advances in both diagnostic and therapeutic procedures in recent years. This has increased the number of patients who may be candidates for intervention and potential improvement in quality of life. However, the expansion of the field also necessitates a broader understanding of how to incorporate both traditional and emerging technologies into the care provided at comprehensive epilepsy centers. This review summarizes both old and new surgical procedures in epilepsy using an example algorithm...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29402268/true-malaria-prevalence-in-children-under-five-bayesian-estimation-using-data-of-malaria-household-surveys-from-three-sub-saharan-countries
#19
Elvire Mfueni, Brecht Devleesschauwer, Angel Rosas-Aguirre, Carine Van Malderen, Patrick T Brandt, Bernhards Ogutu, Robert W Snow, Léon Tshilolo, Dejan Zurovac, Dieter Vanderelst, Niko Speybroeck
BACKGROUND: Malaria is one of the major causes of childhood death in sub-Saharan countries. A reliable estimation of malaria prevalence is important to guide and monitor progress toward control and elimination. The aim of the study was to estimate the true prevalence of malaria in children under five in the Democratic Republic of the Congo, Uganda and Kenya, using a Bayesian modelling framework that combined in a novel way malaria data from national household surveys with external information about the sensitivity and specificity of the malaria diagnostic methods used in those surveys-i...
February 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29402104/developing-an-intervention-for-optimizing-end-of-life-care-in-any-setting
#20
Emily Dobson
The gold standards of care created within the hospice setting are not always effectively influencing national, regional or local policy. This struggle is something which the public health sector has successfully contended with. In particular an approach known as Health in All Policies (HiAP) has been developed to lay down the rules of engagement and guide the exchange between organisations from all sectors. This synergy allows for an exploration of the possibilities of utilising HiAP within end of life care...
January 2018: Annals of Palliative Medicine
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