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https://www.readbyqxmd.com/read/27913320/the-concept-of-effective-inflow-application-to-interictal-localization-of-the-epileptogenic-focus-from-ieeg
#1
Ioannis Vlachos, Balu Krishnan, David Treiman, Konstantinos Tsakalis, Dimitris Kugiumtzis, Leon Iassemidis
GOAL: Accurate determination of the epileptogenic focus is of paramount diagnostic and therapeutic importance in epilepsy. The current gold standard for focus localization is from ictal (seizure) onset and thus requires the occurrence and recording of multiple typical seizures of a patient. Localization of the focus from seizure-free (interictal) periods remains a challenging problem, especially in the absence of interictal epileptiform activity. METHODS: By exploring the concept of effective inflow, we developed a focus localization algorithm (FLA) based on directed connectivity between brain sites...
November 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27911828/evaluating-the-evaluation-of-cancer-driver-genes
#2
Collin J Tokheim, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Rachel Karchin
Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have been developed to identify driver genes, but evaluation of the performance of these methods is hindered by the lack of a gold standard, that is, bona fide driver gene mutations. Here, we establish an evaluation framework that can be applied to driver gene prediction methods. We used this framework to compare the performance of eight such methods. One of these methods, described here, incorporated a machine-learning-based ratiometric approach...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27897779/gold-award-for-prison-health-team
#3
(no author information available yet)
A team from HM Prison Norwich has received the Gold Standards Framework Quality Hallmark Award - the first national recognition of care provided to prisoners in the final months of their lives.
November 16, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27843789/real-world-evidence-an-indian-perspective
#4
REVIEW
Amit Dang, B N Vallish
Randomized controlled trials (RCTs) are the gold standard for measuring the safety and efficacy of drugs. However, they are being challenged by payers and health care providers since they are looking for real world evidence (RWE) to validate whether the new intervention provides similar safety and efficacy as reported in RCT data. RWE uses real world data (RWD) to generate insight, foresight, and explorative findings on diseases, products, and patient populations. There are varied sources of RWD such as administrative data, large pragmatic trials, registries, electronic health records, and health surveys...
October 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27830464/2d-to-3d-fusion-of-echocardiography-and-cardiac-ct-for-tavr-and-tavi-image-guidance
#5
Azira Khalil, Amir Faisal, Khin Wee Lai, Siew Cheok Ng, Yih Miin Liew
This study proposed a registration framework to fuse 2D echocardiography images of the aortic valve with preoperative cardiac CT volume. The registration facilitates the fusion of CT and echocardiography to aid the diagnosis of aortic valve diseases and provide surgical guidance during transcatheter aortic valve replacement and implantation. The image registration framework consists of two major steps: temporal synchronization and spatial registration. Temporal synchronization allows time stamping of echocardiography time series data to identify frames that are at similar cardiac phase as the CT volume...
November 9, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27802082/a-practice-development-initiative-supporting-care-home-staff-deliver-high-quality-end-of-life-care
#6
Jo Hockley, Julie Kinley
BACKGROUND: The global population is changing with an increasing percentage of the oldest old, many of whom in the UK are looked after in care homes. Care homes now provide care for a fifth of the UK population who die each year. However, most nursing care homes are privately owned and not part of the NHS, which exposes staff to a lack of skills/knowledge in relation to end-of-life care. METHODS: To implement the Gold Standards Framework in Care Homes Programme and audit outcomes within nursing care homes across five Clinical Commissioning Groups over a 7-year period using a research-based model of facilitation...
October 2, 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27792722/high-accuracy-hla-type-inference-from-whole-genome-sequencing-data-using-population-reference-graphs
#7
Alexander T Dilthey, Pierre-Antoine Gourraud, Alexander J Mentzer, Nezih Cereb, Zamin Iqbal, Gil McVean
Genetic variation at the Human Leucocyte Antigen (HLA) genes is associated with many autoimmune and infectious disease phenotypes, is an important element of the immunological distinction between self and non-self, and shapes immune epitope repertoires. Determining the allelic state of the HLA genes (HLA typing) as a by-product of standard whole-genome sequencing data would therefore be highly desirable and enable the immunogenetic characterization of samples in currently ongoing population sequencing projects...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27788652/online
#8
(no author information available yet)
In September, a team from HM Prison Norwich received the Gold Standards Framework Quality Hallmark Award. It marked the first national recognition of a prison for care provided to prisoners in the final months of their lives.
October 28, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27770402/a-novel-framework-for-automated-segmentation-and-labeling-of-homogeneous-versus-heterogeneous-lung-tumors-in-18-f-fdg-pet-imaging
#9
Motahare Soufi, Alireza Kamali-Asl, Parham Geramifar, Arman Rahmim
PURPOSE: Determination of intra-tumor high-uptake area using 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomography (PET) imaging is an important consideration for dose painting in radiation treatment applications. The aim of our study was to develop a framework towards automated segmentation and labeling of homogeneous vs. heterogeneous tumors in clinical lung [(18)F]FDG-PET with the capability of intra-tumor high-uptake region delineation. PROCEDURES: We utilized and extended a fuzzy random walk PET tumor segmentation algorithm to delineate intra-tumor high-uptake areas...
October 21, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27747021/ame-evidence-series-001-the-society-for-translational-medicine-clinical-practice-guidelines-for-diagnosis-and-early-identification-of-sepsis-in-the-hospital
#10
Zhongheng Zhang, Nathan J Smischney, Haibo Zhang, Sven Van Poucke, Panagiotis Tsirigotis, Jordi Rello, Patrick M Honore, Win Sen Kuan, Juliet June Ray, Jiancang Zhou, You Shang, Yuetian Yu, Christian Jung, Chiara Robba, Fabio Silvio Taccone, Pietro Caironi, David Grimaldi, Stefan Hofer, George Dimopoulos, Marc Leone, Sang-Bum Hong, Mabrouk Bahloul, Laurent Argaud, Won Young Kim, Herbert D Spapen, Jose Rodolfo Rocco
Sepsis is a heterogeneous disease caused by an infection stimulus that triggers several complex local and systemic immuno-inflammatory reactions, which results in multiple organ dysfunction and significant morbidity and mortality. The diagnosis of sepsis is challenging because there is no gold standard for diagnosis. As a result, the clinical diagnosis of sepsis is ever changing to meet the clinical and research requirements. Moreover, although there are many novel biomarkers and screening tools for predicting the risk of sepsis, the diagnostic performance and effectiveness of these measures are less than satisfactory, and there is insufficient evidence to recommend clinical use of these new techniques...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27719871/physical-treatment-of-functional-neurologic-disorders
#11
G Nielsen
Physical interventions are widely considered an important part of treatment of functional neurologic disorders (FNDs). The evidence base for physical interventions has been limited to a collection of case series, but the recent publication of several large cohort studies and a randomized controlled trial have provided stronger evidence to support its use. While the evidence for efficacy appears to be promising, details on how this should be delivered remain limited, perhaps due to the dominance of psychologically focused etiologic models...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27713905/a-harmonized-data-quality-assessment-terminology-and-framework-for-the-secondary-use-of-electronic-health-record-data
#12
Michael G Kahn, Tiffany J Callahan, Juliana Barnard, Alan E Bauck, Jeff Brown, Bruce N Davidson, Hossein Estiri, Carsten Goerg, Erin Holve, Steven G Johnson, Siaw-Teng Liaw, Marianne Hamilton-Lopez, Daniella Meeker, Toan C Ong, Patrick Ryan, Ning Shang, Nicole G Weiskopf, Chunhua Weng, Meredith N Zozus, Lisa Schilling
OBJECTIVE: Harmonized data quality (DQ) assessment terms, methods, and reporting practices can establish a common understanding of the strengths and limitations of electronic health record (EHR) data for operational analytics, quality improvement, and research. Existing published DQ terms were harmonized to a comprehensive unified terminology with definitions and examples and organized into a conceptual framework to support a common approach to defining whether EHR data is 'fit' for specific uses...
2016: EGEMS
https://www.readbyqxmd.com/read/27680520/surgical-nasal-implants-indications-and-risks
#13
Dane J Genther, Ira D Papel
Rhinoplasty often requires the use of grafting material, and the goal of the specific graft dictates the ideal characteristics of the material to be used. An ideal material would be biologically inert, resistant to infection, noncarcinogenic, nondegradable, widely available, cost-effective, readily modifiable, and easily removable, have compatible biomechanical characteristics, retain physical properties over time, and not migrate. Unfortunately, no material currently in existence meets all of these criteria...
October 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/27672633/a-scoping-review-of-tailored-self-management-interventions-among-adults-with-mobility-impairing-neurological-and-musculoskeletal-conditions
#14
REVIEW
Matthew Plow, Sabrina Mangal, Kathryn Geither, Meghan Golding
A critical public health objective is to optimize and disseminate self-management interventions for the 56.7 million adults living with chronic disabling conditions in the United States. A possible strategy to optimize the effectiveness of self-management interventions is to understand how best to tailor self-management interventions to the needs and circumstances of each participant. Thus, the purpose of this scoping review was to describe randomized controlled trials (RCTs) of tailored self-management interventions in adults with neurological and musculoskeletal conditions that characteristically result in mobility impairments...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27620687/assessing-hitech-implementation-and-lessons-5-years-later
#15
Marsha Gold, Catherine McLAUGHLIN
POLICY POINTS: The expansive goals of the Health Information Technology for Economic and Clinical Health (HITECH) Act required the simultaneous development of a complex and interdependent infrastructure and a wide range of relationships, generating points of vulnerability. While federal legislation can be a powerful stimulus for change, its effectiveness also depends on its ability to accommodate state and local policies and private health care markets. Ambitious goals require support over a long time horizon, which can be challenging to maintain...
September 2016: Milbank Quarterly
https://www.readbyqxmd.com/read/27617835/statistical-analysis-of-tract-tracing-experiments-demonstrates-a-dense-complex-cortical-network-in-the-mouse
#16
Rolf J F Ypma, Edward T Bullmore
Anatomical tract tracing methods are the gold standard for estimating the weight of axonal connectivity between a pair of pre-defined brain regions. Large studies, comprising hundreds of experiments, have become feasible by automated methods. However, this comes at the cost of positive-mean noise making it difficult to detect weak connections, which are of particular interest as recent high resolution tract-tracing studies of the macaque have identified many more weak connections, adding up to greater connection density of cortical networks, than previously recognized...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27616314/an-imaging-based-approach-to-spinal-cord-infection
#17
Jason F Talbott, Jared Narvid, J Levi Chazen, Cynthia T Chin, Vinil Shah
Infections of the spinal cord, nerve roots, and surrounding meninges are uncommon, but highly significant given their potential for severe morbidity and even mortality. Prompt diagnosis can be lifesaving, as many spinal infections are treatable. Advances in imaging technology have now firmly established magnetic resonance imaging (MRI) as the gold standard for spinal cord imaging evaluation, enabling the depiction of infectious myelopathies with exquisite detail and contrast. In this article, we aim to provide an overview of MRI findings for spinal cord infections with special focus on imaging patterns of infection that are primarily confined to the spinal cord, spinal meninges, and spinal nerve roots...
October 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27612933/reporting-of-treatment-fidelity-in-behavioural-paediatric-obesity-intervention-trials-a-systematic-review
#18
REVIEW
M M JaKa, J L Haapala, E S Trapl, A S Kunin-Batson, B A Olson-Bullis, W J Heerman, J M Berge, S M Moore, D Matheson, N E Sherwood
Behavioural interventions for paediatric obesity are promising, but detailed information on treatment fidelity (i.e. design, training, delivery, receipt and enactment) is needed to optimize the implementation of more effective interventions. Little is known about current practices for reporting treatment fidelity in paediatric obesity studies. This systematic review, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, describes the methods used to report treatment fidelity in randomized controlled trials...
December 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27549120/nested-partially-latent-class-models-for-dependent-binary-data-estimating-disease-etiology
#19
Zhenke Wu, Maria Deloria-Knoll, Scott L Zeger
The Pneumonia Etiology Research for Child Health (PERCH) study seeks to use modern measurement technology to infer the causes of pneumonia for which gold-standard evidence is unavailable. Based on case-control data, the article describes a latent variable model designed to infer the etiology distribution for the population of cases, and for an individual case given her measurements. We assume each observation is drawn from a mixture model for which each component represents one disease class. The model conisidered here addresses a major limitation of the traditional latent class approach by taking account of residual dependence among multivariate binary outcomes given disease class, hence reducing estimation bias, retaining efficiency and offering more valid inference...
August 22, 2016: Biostatistics
https://www.readbyqxmd.com/read/27504915/psychometric-properties-of-the-problematic-internet-use-questionnaire-short-form-piuq-sf-6-in-a-nationally-representative-sample-of-adolescents
#20
Zsolt Demetrovics, Orsolya Király, Beatrix Koronczai, Mark D Griffiths, Katalin Nagygyörgy, Zsuzsanna Elekes, Domokos Tamás, Bernadette Kun, Gyöngyi Kökönyei, Róbert Urbán
Despite the large number of measurement tools developed to assess problematic Internet use, numerous studies use measures with only modest investigation into their psychometric properties. The goal of the present study was to validate the short (6-item) version of the Problematic Internet Use Questionnaire (PIUQ) on a nationally representative adolescent sample (n = 5,005; mean age 16.4 years, SD = 0.87) and to determine a statistically established cut-off value. Data were collected within the framework of the European School Survey Project on Alcohol and Other Drugs project...
2016: PloS One
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