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https://www.readbyqxmd.com/read/28331883/practical-no-gold-standard-evaluation-framework-for-quantitative-imaging-methods-application-to-lesion-segmentation-in-positron-emission-tomography
#1
Abhinav K Jha, Esther Mena, Brian Caffo, Saeed Ashrafinia, Arman Rahmim, Eric Frey, Rathan M Subramaniam
Recently, a class of no-gold-standard (NGS) techniques have been proposed to evaluate quantitative imaging methods using patient data. These techniques provide figures of merit (FoMs) quantifying the precision of the estimated quantitative value without requiring repeated measurements and without requiring a gold standard. However, applying these techniques to patient data presents several practical difficulties including assessing the underlying assumptions, accounting for patient-sampling-related uncertainty, and assessing the reliability of the estimated FoMs...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28302061/subgroup-detection-in-genotype-data-using-invariant-coordinate-selection
#2
Daniel Fischer, Mervi Honkatukia, Maria Tuiskula-Haavisto, Klaus Nordhausen, David Cavero, Rudolf Preisinger, Johanna Vilkki
BACKGROUND: The current gold standard in dimension reduction methods for high-throughput genotype data is the Principle Component Analysis (PCA). The presence of PCA is so dominant, that other methods usually cannot be found in the analyst's toolbox and hence are only rarely applied. RESULTS: We present a modern dimension reduction method called 'Invariant Coordinate Selection' (ICS) and its application to high-throughput genotype data. The more commonly known Independent Component Analysis (ICA) is in this framework just a special case of ICS...
March 16, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28285598/diagnostic-performance-of-elisa-ifat-and-western-blot-for-the-detection-of-anti-leishmania-infantum-antibodies-in-cats-using-a-bayesian-analysis-without-a-gold-standard
#3
Maria Flaminia Persichetti, Laia Solano-Gallego, Angela Vullo, Marisa Masucci, Pierre Marty, Pascal Delaunay, Fabrizio Vitale, Maria Grazia Pennisi
BACKGROUND: Anti-Leishmania antibodies are increasingly investigated in cats for epidemiological studies or for the diagnosis of clinical feline leishmaniosis. The immunofluorescent antibody test (IFAT), the enzyme-linked immunosorbent assay (ELISA) and western blot (WB) are the serological tests more frequently used. The aim of the present study was to assess diagnostic performance of IFAT, ELISA and WB to detect anti-L. infantum antibodies in feline serum samples obtained from endemic (n = 76) and non-endemic (n = 64) areas and from cats affected by feline leishmaniosis (n = 21) by a Bayesian approach without a gold standard...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28275348/cerebromatic-a-versatile-toolbox-for-spline-based-mri-template-creation
#4
Marko Wilke, Mekibib Altaye, Scott K Holland
Brain image spatial normalization and tissue segmentation rely on prior tissue probability maps. Appropriately selecting these tissue maps becomes particularly important when investigating "unusual" populations, such as young children or elderly subjects. When creating such priors, the disadvantage of applying more deformation must be weighed against the benefit of achieving a crisper image. We have previously suggested that statistically modeling demographic variables, instead of simply averaging images, is advantageous...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28269623/a-framework-for-informing-segmentation-of-in-vivo-mri-with-information-derived-from-ex-vivo-imaging-application-in-the-medial-temporal-lobe
#5
Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk
Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the "bronze" standard of manual segmentation of test MRI datasets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269157/image-classification-of-unlabeled-malaria-parasites-in-red-blood-cells
#6
Zheng Zhang, L L Sharon Ong, Kong Fang, Athul Matthew, Justin Dauwels, Ming Dao, Harry Asada
This paper presents a method to detect unlabeled malaria parasites in red blood cells. The current "gold standard" for malaria diagnosis is microscopic examination of thick blood smear, a time consuming process requiring extensive training. Our goal is to develop an automate process to identify malaria infected red blood cells. Major issues in automated analysis of microscopy images of unstained blood smears include overlapping cells and oddly shaped cells. Our approach creates robust templates to detect infected and uninfected red cells...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268800/a-daytime-obstructive-sleep-apnea-severity-assessment-framework
#7
Lauren Samy, Paul M Macey, Majid Sarrafzadeh
Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway. These episodes can interfere with sound sleep and have fatal health consequences. They can also reduce the flow of oxygen to vital organs, like the brain, and lead to brain damage. In this paper, we leverage the correlation between brain damage and OSA to design a prediction framework that can assess the severity level of the OSA condition, as well as estimate the Apnea-Hypopnea Index (AHI) using only features obtained during wakefulness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268582/a-new-approach-of-oral-cancer-detection-using-bilateral-texture-features-in-digital-infrared-thermal-images
#8
M Chakraborty, S Mukhopadhyay, A Dasgupta, S Patsa, N Anjum, J G Ray
Oral cancer is one of the most prevalent form of cancer and its severity is aggrandized specially among the socio-economically backward population in developing countries. A major fraction of patient population is unable to avail diagnosis for oral cancer due to scarcity of state-of-the-art infrastructure and experienced oral and maxillofacial pathologist. Contemporary gold standard of oral cancer confirmation relies on biopsy report. But biopsy is invasive and thus patients are usually reluctant to undergo this test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28252976/trial-1-versus-trial-2-of-the-test-of-memory-malingering-evaluating-accuracy-without-a-gold-standard
#9
Douglas Mossman, Dustin B Wygant, Roger O Gervais, Kathleen J Hart
This study examines the accuracy of the Test of Memory Malingering (TOMM), a frequently administered measure for evaluating effort during neurocognitive testing. In the last few years, several authors have suggested that the initial recognition trial of the TOMM (Trial 1) might be a more useful index for detecting feigned or exaggerated impairment than Trial 2, which is the source for inference recommended by the original instruction manual (Tombaugh, 1996). We used latent class modeling (LCM) implemented in a Bayesian framework to evaluate archival Trial 1 and Trial 2 data collected from 1,198 adults who had undergone outpatient forensic evaluations...
March 2, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28247760/theoretical-predictions-of-a-new-%C3%A2-14-kda-core-mass-thiolate-protected-gold-nanoparticle-au68-sr-36
#10
Pu Wang, Xiangxiang Sun, Xia Liu, Lin Xiong, Zhongyun Ma, Yong Pei
As an important intermediate link between the smaller and larger size thiolate-protected gold nanoparticles (RS-AuNPs), the molecular formula and atomic structure of the ∼14 kDa core-mass RS-AuNP species (containing around 70 core gold atoms) have not been determined unambiguously. In this work, we theoretically predict an unprecedented ∼14 kDa core-mass AuNP species, denoted as Au68(SR)36, which is composed a symmetric, face-centered-cubic (fcc) 68-gold atom framework. The fcc gold kernel in the Au68(SR)36 is made of eight 13-atom Au-cubotahedrons sharing 12 square faces, showing a standard 2 × 2 × 2 magic cube formula...
March 3, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28240078/using-the-gold-standards-framework-to-deliver-good-end-of-life-care
#11
Barry Quinn, Keri Thomas
The aims of excellent end of life care (EOLC) and nursing are at the heart of healthcare. Chelsea and Westminster Hospital NHS Foundation Trust, a multi-site London teaching care provider, recognises and values the importance of good EOLC, and the quality of EOLC is used as one of the key metrics in assessing the quality of patient and family care across the trust. The principles of EOLC, including those enshrined in the Gold Standards Framework (GSF), are closely aligned with the trust's core values. Each member of staff is encouraged and supported, through the GSF process, to recognise and respond as befits their role in implementing the principles of EOLC, agreed by staff, and by patients and their relatives...
February 27, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28236658/targeted-dose-enhancement-in-radiotherapy-for-breast-cancer-using-gold-nanoparticles-part-2-a-treatment-planning-study
#12
Lidia Strigari, Veronica Ferrero, Giovanni Visonà, Piergiorgio Cerello, Andrea Attili, Sonja Visentin
PURPOSE: In recent years there has been growing interest in the use of gold nanoparticles (GNPs) combined with radiotherapy to improve tumor control. However, the complex interplay between GNP uptake and dose distribution in realistic clinical treatment are still somewhat unknown. METHODS: The effects of different concentrations of 2 nm diameter GNP, ranging from 0 to 5x10(5) nanoparticles per tumoral cell, were theoretically investigated. A parametrization of the GNP distribution outside the target was carried out using a Gaussian standard deviation σ, from a zero value, relative to a selective concentration of GNPs inside the tumor volume alone, to 50 mm, when GNPs are spatially distributed also in the healthy tissues surrounding the tumor...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28236117/3d-ultrasound-registration-based-visual-servoing-for-neurosurgical-navigation
#13
Oliver Zettinig, Benjamin Frisch, Salvatore Virga, Marco Esposito, Anna Rienmüller, Bernhard Meyer, Christoph Hennersperger, Yu-Mi Ryang, Nassir Navab
PURPOSE: We present a fully image-based visual servoing framework for neurosurgical navigation and needle guidance. The proposed servo-control scheme allows for compensation of target anatomy movements, maintaining high navigational accuracy over time, and automatic needle guide alignment for accurate manual insertions. METHOD: Our system comprises a motorized 3D ultrasound (US) transducer mounted on a robotic arm and equipped with a needle guide. It continuously registers US sweeps in real time with a pre-interventional plan based on CT or MR images and annotations...
February 24, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28227881/a-framework-for-informing-segmentation-of-in-vivo-mri-with-information-derived-from-ex-vivo-imaging-application-in-the-medial-temporal-lobe
#14
Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, John L Robinson, Jon B Toledo, Stephen Pickup, Weixia Liu, Paul A Yushkevich, Daniel Adler, John Q Trojanowski, Theresa Schuck, David A Wolk, Laura Wisse, Mark A Elliott, Sandhitsu R Das, John A Detre, John B Pluta, Ranjit Ittyerah, Murray Grossman
Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the "bronze" standard of manual segmentation of test MRI datasets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227386/image-classification-of-unlabeled-malaria-parasites-in-red-blood-cells
#15
Zheng Zhang, L L Sharon Ong, Kong Fang, Athul Matthew, Justin Dauwels, Ming Dao, Harry Asada, Zheng Zhang, L L Sharon Ong, Kong Fang, Athul Matthew, Justin Dauwels, Ming Dao, Harry Asada, Justin Dauwels, Zheng Zhang, Kong Fang, Ming Dao, Harry Asada
This paper presents a method to detect unlabeled malaria parasites in red blood cells. The current "gold standard" for malaria diagnosis is microscopic examination of thick blood smear, a time consuming process requiring extensive training. Our goal is to develop an automate process to identify malaria infected red blood cells. Major issues in automated analysis of microscopy images of unstained blood smears include overlapping cells and oddly shaped cells. Our approach creates robust templates to detect infected and uninfected red cells...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226995/a-daytime-obstructive-sleep-apnea-severity-assessment-framework
#16
Lauren Samy, Paul M Macey, Majid Sarrafzadeh, Lauren Samy, Paul M Macey, Majid Sarrafzadeh, Majid Sarrafzadeh, Lauren Samy
Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway. These episodes can interfere with sound sleep and have fatal health consequences. They can also reduce the flow of oxygen to vital organs, like the brain, and lead to brain damage. In this paper, we leverage the correlation between brain damage and OSA to design a prediction framework that can assess the severity level of the OSA condition, as well as estimate the Apnea-Hypopnea Index (AHI) using only features obtained during wakefulness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226760/a-new-approach-of-oral-cancer-detection-using-bilateral-texture-features-in-digital-infrared-thermal-images
#17
M Chakraborty, S Mukhopadhyay, A Dasgupta, S Patsa, N Anjum, J G Ray, M Chakraborty, S Mukhopadhyay, A Dasgupta, S Patsa, N Anjum, J G Ray, S Patsa, A Dasgupta, N Anjum, M Chakraborty, S Mukhopadhyay, J G Ray
Oral cancer is one of the most prevalent form of cancer and its severity is aggrandized specially among the socio-economically backward population in developing countries. A major fraction of patient population is unable to avail diagnosis for oral cancer due to scarcity of state-of-the-art infrastructure and experienced oral and maxillofacial pathologist. Contemporary gold standard of oral cancer confirmation relies on biopsy report. But biopsy is invasive and thus patients are usually reluctant to undergo this test...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28203385/appraising-the-methodological-quality-of-the-clinical-practice-guideline-for-diabetes-mellitus-using-the-agree-ii-instrument-a-methodological-evaluation
#18
Mahmoud Radwan, Ali Akbari Sari, Arash Rashidian, Amirhossein Takian, Sanaa Abou-Dagga, Aymen Elsous
OBJECTIVES: To evaluate the methodological quality of the Palestinian Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II. DESIGN: Methodological evaluation. A cross-cultural adaptation framework was followed to translate and develop a standardised Translated Arabic Version of the AGREE II. SETTING: Palestinian Primary Healthcare Centres. PARTICIPANTS: Sixteen appraisers independently evaluated the Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II...
February 2017: JRSM Open
https://www.readbyqxmd.com/read/28198580/can-nursing-epistemology-embrace-p-values
#19
Christine H K Ou, Wendy A Hall, Sally E Thorne
The use of correlational probability values (p-values) as a means of evaluating evidence in nursing and health care has largely been accepted uncritically. There are reasons to be concerned about an uncritical adherence to the use of significance testing, which has been located in the natural science paradigm. p-values have served in hypothesis and statistical testing, such as in randomized controlled trials and meta-analyses to support what has been portrayed as the highest levels of evidence in the framework of evidence-based practice...
February 15, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/28169135/case-study-and-case-based-research-in-emergency-nursing-and-care-theoretical-foundations-and-practical-application-in-paramedic-pre-hospital-clinical-judgment-and-decision-making-of-patients-with-mental-illness
#20
Ramon Z Shaban, Julie Considine, Margaret Fry, Kate Curtis
Generating knowledge through quality research is fundamental to the advancement of professional practice in emergency nursing and care. There are multiple paradigms, designs and methods available to researchers to respond to challenges in clinical practice. Systematic reviews, randomised control trials and other forms of experimental research are deemed the gold standard of evidence, but there are comparatively few such trials in emergency care. In some instances it is not possible or appropriate to undertake experimental research...
February 2017: Australasian Emergency Nursing Journal: AENJ
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