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https://www.readbyqxmd.com/read/29226494/how-does-routinely-delivered-cognitive-behavioural-therapy-for-gambling-disorder-compare-to-gold-standard-clinical-trial
#1
David P Smith, A Kate Fairweather-Schmidt, Peter W Harvey, Malcolm W Battersby
Currently, it is unknown whether treatment outcomes derived from randomized controlled trials (RCTs) of cognitive-behavioural therapy (CBT) for problem gamblers still hold when applied to patients seen in routine practice. Thus, data from an RCT of cognitive therapy versus exposure therapy for problem gambling versus patients of a gambling help service were compared. Assessments of problem gambling severity, psychosocial impairment, and alcohol use were undertaken at baseline and post-treatment and evaluated within a counterfactual framework...
December 11, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29201973/the-accuracy-of-four-impression-making-techniques-in-angulated-implants-based-on-vertical-gap
#2
Abolfazl Saboury, Hamid Neshandar Asli, Zahra Dalili Kajan
Statement of the Problem: Precision of the impression taken from implant positions significantly determines accurate fit of implant-supported prostheses. An imprecise impression may produce prosthesis misfit. Purpose: This study aimed to evaluate the accuracy of four impression-making techniques for angulated implants by stereomicroscope through measuring the vertical marginal gaps between the cemented metal framework and the implant analog. Materials and Method: A definitive cast with two 15° mesially angulated implants served as the standard reference for making all the impressions and later for accuracy evaluation...
December 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29186523/dna-based-mutation-assay-gpma-genome-profiling-based-mutation-assay-reproducibility-parts-per-billion-scale-sensitivity-and-introduction-of-a-mammalian-cell-based-approach
#3
Parmila Kumari, Sunita Ghimire Gautam, Misato Baba, Motoki Tsukiashi, Koji Matsuoka, Kiyoshi Yasukawa, Koichi Nishigaki
Genome profiling-based mutation assay (GPMA) is, to date, the only DNA sequence-based mutation assay that directly measures DNA alterations induced by mutagens. Here, the all-important congruence of mutagen assignment between DNA-based GPMA and the phenotype-based Ames test (the gold standard of mutagen assays) was confirmed qualitatively and semi-quantitatively by means of 94 chemical species (including previously examined 64). The high sensitivity (on the order of 10 ppb) and reproducibility of GPMA were also corroborated by the match between virtually independent experiments conducted in the distant past (10 years ago) and recently...
December 1, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29182056/lesion-segmentation-in-automated-3d-breast-ultrasound-volumetric-analysis
#4
Richa Agarwal, Oliver Diaz, Xavier Lladó, Albert Gubern-Mérida, Joan C Vilanova, Robert Martí
Mammography is the gold standard screening technique in breast cancer, but it has some limitations for women with dense breasts. In such cases, sonography is usually recommended as an additional imaging technique. A traditional sonogram produces a two-dimensional (2D) visualization of the breast and is highly operator dependent. Automated breast ultrasound (ABUS) has also been proposed to produce a full 3D scan of the breast automatically with reduced operator dependency, facilitating double reading and comparison with past exams...
November 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/29176452/collagen-based-fillers-as-alternatives-to-cyanoacrylate-glue-for-the-sealing-of-large-corneal-perforations
#5
Chameen Samarawickrama, Ayan Samanta, Aneta Liszka, Per Fagerholm, Oleksiy Buznyk, May Griffith, Bruce Allan
PURPOSE: To describe the use of collagen-based alternatives to cyanoacrylate glue for the sealing of acute corneal perforations. METHODS: A collagen analog comprising a collagen-like peptide conjugated to polyethylene glycol (CLP-PEG) and its chemical crosslinker were tested for biocompatibility. These CLP-PEG hydrogels, which are designed to act as a framework for corneal tissue regeneration, were then tested as potential fillers in ex vivo human corneas with surgically created full-thickness perforations...
November 22, 2017: Cornea
https://www.readbyqxmd.com/read/29168990/model-based-meta-analysis-for-multiple-myeloma-a-quantitative-drug-independent-framework-for-efficient-decisions-in-oncology-drug-development
#6
Zhaoyang Teng, Neeraj Gupta, Zhaowei Hua, Guohui Liu, Vivek Samnotra, Karthik Venkatakrishnan, Richard Labotka
The failure rate for phase III trials in oncology is high; quantitative predictive approaches are needed. We developed a model-based meta-analysis (MBMA) framework to predict progression-free survival (PFS) from overall response rates (ORR) in relapsed/refractory multiple myeloma (RRMM), using data from seven phase III trials. A Bayesian analysis was used to predict the probability of technical success (PTS) for achieving desired phase III PFS targets based on phase II ORR data. The model demonstrated a strongly correlated (R(2) = 0...
November 23, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29143632/a-method-for-estimating-maternal-and-newborn-lives-saved-from-health-related-investments-funded-by-the-uk-government-department-for-international-development-using-the-lives-saved-tool
#7
Ingrid K Friberg, Angela Baschieri, Jo Abbotts
BACKGROUND: In 2010, the UK Government Department for International Development (DFID) committed through its 'Framework for results for reproductive, maternal and newborn health (RMNH)' to save 50,000 maternal lives and 250,000 newborn lives by 2015. They also committed to monitoring the performance of this portfolio of investments to demonstrate transparency and accountability. Methods currently available to directly measure lives saved are cost-, time-, and labour-intensive. The gold standard for calculating the total number of lives saved would require measuring mortality with large scale population based surveys or annual vital events surveillance...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29127664/larvalign-aligning-gene-expression-patterns-from-the-larval-brain-of-drosophila-melanogaster
#8
Sascha E A Muenzing, Martin Strauch, James W Truman, Katja Bühler, Andreas S Thum, Dorit Merhof
The larval brain of the fruit fly Drosophila melanogaster is a small, tractable model system for neuroscience. Genes for fluorescent marker proteins can be expressed in defined, spatially restricted neuron populations. Here, we introduce the methods for 1) generating a standard template of the larval central nervous system (CNS), 2) spatial mapping of expression patterns from different larvae into a reference space defined by the standard template. We provide a manually annotated gold standard that serves for evaluation of the registration framework involved in template generation and mapping...
November 10, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/29112702/commwalker-correctly-evaluating-modules-in-molecular-networks-in-light-of-annotation-bias
#9
M D Luecken, M J T Page, A J Crosby, S Mason, G Reinert, C M Deane
Motivation: Detecting novel functional modules in molecular networks is an important step in biological research. In the absence of gold standard functional modules, functional annotations are often used to verify whether detected modules/communities have biological meaning. However, as we show, the uneven distribution of functional annotations means that such evaluation methods favour communities of well-studied proteins. Results: We propose a novel framework for the evaluation of communities as functional modules...
November 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29106377/an-interdimensional-correlation-framework-for-real-time-estimation-of-six-degree-of-freedom-target-motion-using-a-single-x-ray-imager-during-radiotherapy
#10
Doan Trang Nguyen, Jenny Bertholet, Jungha Kim, Ricky T O'Brien, Jeremy Todd Booth, Per Rugaard Poulsen, Paul J Keall
Increasing evidence suggests that intrafraction tumour motion monitoring needs to include both 3D translations and 3D rotations. Presently, methods to estimate the rotation motion require the 3D translation of the target to be known first. However, ideally, translation and rotation should be estimated concurrently. We present the first method to directly estimate six-degree-of-freedom (6DoF) motion from the target's projection on a single rotating x-ray imager in real-time. Methods: This novel method is based on the linear correlations between the superior-inferior translations and the motion in the other five degrees-of-freedom...
November 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29100114/wall-based-measurement-features-provides-an-improved-ivus-coronary-artery-risk-assessment-when-fused-with-plaque-texture-based-features-during-machine-learning-paradigm
#11
Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
BACKGROUND: Planning of percutaneous interventional procedures involves a pre-screening and risk stratification of the coronary artery disease. Current screening tools use stand-alone plaque texture-based features and therefore lack the ability to stratify the risk. METHOD: This IRB approved study presents a novel strategy for coronary artery disease risk stratification using an amalgamation of IVUS plaque texture-based and wall-based measurement features. Due to common genetic plaque makeup, carotid plaque burden was chosen as a gold standard for risk labels during training-phase of machine learning (ML) paradigm...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29097287/palliative-and-end-of-life-care-of-people-with-diabetes-issues-challenges-and-strategies
#12
REVIEW
Trisha Dunning, Peter Martin
Palliative and end of life care are essential, but largely overlooked, aspects of comprehensive, personalised diabetes care. Life expectancy is lower in people with diabetes than in the general population due to complications and comorbidities, especially those associated with obesity such as cardiovascular disease, frailty and cancer. This paper makes the case for early initiation of palliative care and proactive planning for end of life. Early use of palliative care improves symptom management, comfort and quality of life, and often improves function...
October 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29060741/accurate-estimation-of-joint-motion-trajectories-for-rehabilitation-using-kinect
#13
Sanjana Sinha, Brojeshwar Bhowmick, Aniruddha Sinha, Abhijit Das
Kinect as an effective tool for clinical assessment and rehabilitation, suffers from drawbacks of lower accuracy of measuring human body kinematic data when compared to clinical gold standard motion capture devices. The accuracy of time-varying 3D locations of a fixed number of body joints obtained from Kinect skeletal tracking utility is affected by the presence of noise and precision limits of the Kinect depth sensor. In this paper, a framework for improving accuracy of Kinect skeletal tracking is proposed, that uses a set of parametric models to represent and track the human body...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29026234/compliance-with-the-guide-for-commissioning-oral-surgery-an-audit-and-discussion
#14
O Modgill, A Shah
Introduction The Guide for commissioning oral surgery and oral medicine published by NHS England (2015) prescribes the level of complexity of oral surgery and oral medicine investigations and procedures to be carried out within NHS services. These are categorised as Level 1, Level 2, Level 3A and Level 3B. An audit was designed to ascertain the level of oral surgery procedures performed by clinicians of varying experience and qualification working in a large oral surgery department within a major teaching hospital...
October 13, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29024847/how-children-remember-the-strange-situation-the-role-of-attachment
#15
Yoojin Chae, Miranda Goodman, Gail S Goodman, Natalie Troxel, Kelly McWilliams, Ross A Thompson, Phillip R Shaver, Keith F Widaman
This study tested predictions from Bowlby's attachment theory about children's memory and suggestibility. Young children (3-5years old, N=88; 76% Caucasians) and their parents took part in the Strange Situation Procedure, a moderately distressing event and "gold standard" for assessing children's attachment quality. The children were then interviewed about what occurred during the event. Children's age and attachment security scores positively predicted correct information in free recall and accuracy in answering specific questions...
February 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29017690/the-range-and-scientific-value-of-randomized-trials
#16
Stefan Lange, Stefan Sauerland, Jörg Lauterberg, Jürgen Windeler
BACKGROUND: The randomized, controlled trial (RCT) is the gold standard of scientific evidence for the attribution of clinical effects (benefits and harms) to medical interventions. Many different designs for RCTs have been developed in order to counter legitimate critical objections and to better adapt the trials to the continually changing challenges that face clinical research. METHODS: The diversity and adaptability of randomized trial designs are presented and discussed on the basis of a selective literature review and specific illustrative examples...
September 22, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28960808/development-of-a-course-on-complex-humanitarian-emergencies-preparation-for-the-impact-of-climate-change
#17
Holly Williams, Elizabeth Downes
PURPOSE: The effects of climate change are far-reaching and multifactorial, with potential impacts on food security and conflict. Large population movements, whether from the aftermath of natural disasters or resulting from conflict, can precipitate the need for humanitarian response in what can become complex humanitarian emergencies (CHEs). Nurses need to be prepared to respond to affected communities in need, whether the emergency is domestic or global. The purpose of the article is to describe a novel course for nursing students interested in practice within the confines of CHEs and natural disasters...
September 28, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28910696/tissue-microstructure-estimation-using-a-deep-network-inspired-by-a-dictionary-based-framework
#18
Chuyang Ye
Diffusion magnetic resonance imaging (dMRI) captures the anisotropic pattern of water displacement in the neuronal tissue and allows noninvasive investigation of the complex tissue microstructure. A number of biophysical models have been proposed to relate the tissue organization with the observed diffusion signals, so that the tissue microstructure can be inferred. The Neurite Orientation Dispersion and Density Imaging (NODDI) model has been a popular choice and has been widely used for many neuroscientific studies...
September 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28845370/seismocardiography-based-cardiac-computed-tomography-gating-using-patient-specific-template-identification-and-detection
#19
Jingting Yao, Srini Tridandapani, Carson A Wick, Pamela T Bhatti
To more accurately trigger cardiac computed tomography angiography (CTA) than electrocardiography (ECG) alone, a sub-system is proposed as an intermediate step toward fusing ECG with seismocardiography (SCG). Accurate prediction of quiescent phases is crucial to prospectively gating CTA, which is susceptible to cardiac motion and, thus, can affect the diagnostic quality of images. The key innovation of this sub-system is that it identifies the SCG waveform corresponding to heart sounds and determines their phases within the cardiac cycles...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28839110/validation-of-immunohistochemical-assays-for-integral-biomarkers-in-the-nci-match-eay131-clinical-trial
#20
Joseph D Khoury, Wei-Lien Wang, Victor G Prieto, L Jeffrey Medeiros, Neda Kalhor, Meera Hameed, Russell Broaddus, Stanley R Hamilton
Biomarkers that guide therapy selection are gaining unprecedented importance as targeted therapy options increase in scope and complexity. In conjunction with high-throughput molecular techniques, therapy-guiding biomarker assays based upon immunohistochemistry (IHC) have a critical role in cancer care in that they inform about the presence of a protein target. Here, we describe the validation procedures for four clinically available IHC biomarker assays - PTEN, RB, MLH1 and MSH2 - for use as integral biomarkers in the nationwide NCI-MATCH (Molecular Analysis for Therapy Choice) EAY131 clinical trial...
August 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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