Read by QxMD icon Read

Gold standard framework

Zhongheng Zhang, Nathan J Smischney, Haibo Zhang, Sven Van Poucke, Panagiotis Tsirigotis, Jordi Rello, Patrick M Honore, Win Sen Kuan, Juliet June Ray, Jiancang Zhou, You Shang, Yuetian Yu, Christian Jung, Chiara Robba, Fabio Silvio Taccone, Pietro Caironi, David Grimaldi, Stefan Hofer, George Dimopoulos, Marc Leone, Sang-Bum Hong, Mabrouk Bahloul, Laurent Argaud, Won Young Kim, Herbert D Spapen, Jose Rodolfo Rocco
Sepsis is a heterogeneous disease caused by an infection stimulus that triggers several complex local and systemic immuno-inflammatory reactions, which results in multiple organ dysfunction and significant morbidity and mortality. The diagnosis of sepsis is challenging because there is no gold standard for diagnosis. As a result, the clinical diagnosis of sepsis is ever changing to meet the clinical and research requirements. Moreover, although there are many novel biomarkers and screening tools for predicting the risk of sepsis, the diagnostic performance and effectiveness of these measures are less than satisfactory, and there is insufficient evidence to recommend clinical use of these new techniques...
September 2016: Journal of Thoracic Disease
G Nielsen
Physical interventions are widely considered an important part of treatment of functional neurologic disorders (FNDs). The evidence base for physical interventions has been limited to a collection of case series, but the recent publication of several large cohort studies and a randomized controlled trial have provided stronger evidence to support its use. While the evidence for efficacy appears to be promising, details on how this should be delivered remain limited, perhaps due to the dominance of psychologically focused etiologic models...
2017: Handbook of Clinical Neurology
Michael G Kahn, Tiffany J Callahan, Juliana Barnard, Alan E Bauck, Jeff Brown, Bruce N Davidson, Hossein Estiri, Carsten Goerg, Erin Holve, Steven G Johnson, Siaw-Teng Liaw, Marianne Hamilton-Lopez, Daniella Meeker, Toan C Ong, Patrick Ryan, Ning Shang, Nicole G Weiskopf, Chunhua Weng, Meredith N Zozus, Lisa Schilling
OBJECTIVE: Harmonized data quality (DQ) assessment terms, methods, and reporting practices can establish a common understanding of the strengths and limitations of electronic health record (EHR) data for operational analytics, quality improvement, and research. Existing published DQ terms were harmonized to a comprehensive unified terminology with definitions and examples and organized into a conceptual framework to support a common approach to defining whether EHR data is 'fit' for specific uses...
2016: EGEMS
Dane J Genther, Ira D Papel
Rhinoplasty often requires the use of grafting material, and the goal of the specific graft dictates the ideal characteristics of the material to be used. An ideal material would be biologically inert, resistant to infection, noncarcinogenic, nondegradable, widely available, cost-effective, readily modifiable, and easily removable, have compatible biomechanical characteristics, retain physical properties over time, and not migrate. Unfortunately, no material currently in existence meets all of these criteria...
October 2016: Facial Plastic Surgery: FPS
Matthew Plow, Sabrina Mangal, Kathryn Geither, Meghan Golding
A critical public health objective is to optimize and disseminate self-management interventions for the 56.7 million adults living with chronic disabling conditions in the United States. A possible strategy to optimize the effectiveness of self-management interventions is to understand how best to tailor self-management interventions to the needs and circumstances of each participant. Thus, the purpose of this scoping review was to describe randomized controlled trials (RCTs) of tailored self-management interventions in adults with neurological and musculoskeletal conditions that characteristically result in mobility impairments...
2016: Frontiers in Public Health
Marsha Gold, Catherine McLAUGHLIN
POLICY POINTS: The expansive goals of the Health Information Technology for Economic and Clinical Health (HITECH) Act required the simultaneous development of a complex and interdependent infrastructure and a wide range of relationships, generating points of vulnerability. While federal legislation can be a powerful stimulus for change, its effectiveness also depends on its ability to accommodate state and local policies and private health care markets. Ambitious goals require support over a long time horizon, which can be challenging to maintain...
September 2016: Milbank Quarterly
Rolf J F Ypma, Edward T Bullmore
Anatomical tract tracing methods are the gold standard for estimating the weight of axonal connectivity between a pair of pre-defined brain regions. Large studies, comprising hundreds of experiments, have become feasible by automated methods. However, this comes at the cost of positive-mean noise making it difficult to detect weak connections, which are of particular interest as recent high resolution tract-tracing studies of the macaque have identified many more weak connections, adding up to greater connection density of cortical networks, than previously recognized...
September 2016: PLoS Computational Biology
Jason F Talbott, Jared Narvid, J Levi Chazen, Cynthia T Chin, Vinil Shah
Infections of the spinal cord, nerve roots, and surrounding meninges are uncommon, but highly significant given their potential for severe morbidity and even mortality. Prompt diagnosis can be lifesaving, as many spinal infections are treatable. Advances in imaging technology have now firmly established magnetic resonance imaging (MRI) as the gold standard for spinal cord imaging evaluation, enabling the depiction of infectious myelopathies with exquisite detail and contrast. In this article, we aim to provide an overview of MRI findings for spinal cord infections with special focus on imaging patterns of infection that are primarily confined to the spinal cord, spinal meninges, and spinal nerve roots...
October 2016: Seminars in Ultrasound, CT, and MR
M M JaKa, J L Haapala, E S Trapl, A S Kunin-Batson, B A Olson-Bullis, W J Heerman, J M Berge, S M Moore, D Matheson, N E Sherwood
Behavioural interventions for paediatric obesity are promising, but detailed information on treatment fidelity (i.e. design, training, delivery, receipt and enactment) is needed to optimize the implementation of more effective interventions. Little is known about current practices for reporting treatment fidelity in paediatric obesity studies. This systematic review, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, describes the methods used to report treatment fidelity in randomized controlled trials...
September 9, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Zhenke Wu, Maria Deloria-Knoll, Scott L Zeger
The Pneumonia Etiology Research for Child Health (PERCH) study seeks to use modern measurement technology to infer the causes of pneumonia for which gold-standard evidence is unavailable. Based on case-control data, the article describes a latent variable model designed to infer the etiology distribution for the population of cases, and for an individual case given her measurements. We assume each observation is drawn from a mixture model for which each component represents one disease class. The model conisidered here addresses a major limitation of the traditional latent class approach by taking account of residual dependence among multivariate binary outcomes given disease class, hence reducing estimation bias, retaining efficiency and offering more valid inference...
August 22, 2016: Biostatistics
Zsolt Demetrovics, Orsolya Király, Beatrix Koronczai, Mark D Griffiths, Katalin Nagygyörgy, Zsuzsanna Elekes, Domokos Tamás, Bernadette Kun, Gyöngyi Kökönyei, Róbert Urbán
Despite the large number of measurement tools developed to assess problematic Internet use, numerous studies use measures with only modest investigation into their psychometric properties. The goal of the present study was to validate the short (6-item) version of the Problematic Internet Use Questionnaire (PIUQ) on a nationally representative adolescent sample (n = 5,005; mean age 16.4 years, SD = 0.87) and to determine a statistically established cut-off value. Data were collected within the framework of the European School Survey Project on Alcohol and Other Drugs project...
2016: PloS One
Vincent Gras, Ezequiel Farrher, Farida Grinberg, N Jon Shah
PURPOSE: To design a general framework for the optimization of an MRI protocol based on the the diffusion-weighted dual-echo steady-state (DW-DESS) sequence, enabling quantitative and simultaneous mapping of proton density (PD), relaxation times T1 and T2 and diffusion coefficient D. METHODS: A parameterization of the DW-DESS sequence minimizing the Cramér-Rao lower bound of each parameter estimate was proposed and tested in a phantom experiment. An extension of the protocol was implemented for brain imaging to return the rotationally invariant mean diffusivity (MD)...
August 1, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Lenora Marcellus, Karen MacKinnon
The philosophical framework of family-centered care (FCC) has been promoted consistently since the 1980s in perinatal and neonatal settings as a gold standard approach for developing programs and providing care that supports the meaningful involvement of parents in the care of their infants and children. Recent literature suggests that despite years of promotion, FCC remains an elusive practice. Sources frequently state that FCC is based on principles of communication and empowerment, but the literature overall does not suggest substantial underlying philosophical or theoretical underpinnings...
July 2016: Journal of Perinatal & Neonatal Nursing
Martin Law, Dan Jackson, Rebecca Turner, Kirsty Rhodes, Wolfgang Viechtbauer
BACKGROUND: Meta-analysis is a valuable tool for combining evidence from multiple studies. Network meta-analysis is becoming more widely used as a means to compare multiple treatments in the same analysis. However, a network meta-analysis may exhibit inconsistency, whereby the treatment effect estimates do not agree across all trial designs, even after taking between-study heterogeneity into account. We propose two new estimation methods for network meta-analysis models with random inconsistency effects...
2016: BMC Medical Research Methodology
Fabien Scalzo, David S Liebeskind
Visualization and quantification of blood flow are essential for the diagnosis and treatment evaluation of cerebrovascular diseases. For rapid imaging of the cerebrovasculature, digital subtraction angiography (DSA) remains the gold standard as it offers high spatial resolution. This paper lays out a methodological framework, named perfusion angiography, for the quantitative analysis and visualization of blood flow parameters from DSA images. The parameters, including cerebral blood flow (CBF) and cerebral blood volume (CBV), mean transit time (MTT), time-to-peak (TTP), and T max, are computed using a bolus tracking method based on the deconvolution of the time-density curve on a pixel-by-pixel basis...
2016: Computational and Mathematical Methods in Medicine
Na Hong, Dingcheng Li, Yue Yu, Qiongying Xiu, Hongfang Liu, Guoqian Jiang
BACKGROUND: Constructing standard and computable clinical diagnostic criteria is an important but challenging research field in the clinical informatics community. The Quality Data Model (QDM) is emerging as a promising information model for standardizing clinical diagnostic criteria. OBJECTIVE: To develop and evaluate automated methods for converting textual clinical diagnostic criteria in a structured format using QDM. METHODS: We used a clinical Natural Language Processing (NLP) tool known as cTAKES to detect sentences and annotate events in diagnostic criteria...
July 19, 2016: Journal of Biomedical Informatics
Su Han, Rui Chen, Wenjuan Fang, Rong Fu, Jingshan Wen, Xiaoli Zhang, Xiao Ma
BACKGROUND: Cystic echinococcosis (CE) is a public health problem in China. However, the prevalence and incidence of CE in Heilongjiang province is still poorly understood. Because there is no perfect gold standard, evaluation of ultrasound (US) and serological methods have been limited. This study evaluated the use of these two diagnostic methods for the diagnosis of CE in suspected cases. METHODS: A total of 522 suspected hepatic CE patients, as well as their demographic and clinical features were collected and detected by immunoglobulin (IgG)-ELISA and US...
October 2016: Acta Tropica
Andrea B Troxel, David A Asch, Kevin G Volpp
BACKGROUND: Randomized clinical trials provide gold-standard evidence for the efficacy of interventions, but have limitations, including highly selected populations that make inference on effectiveness difficult and a lack of ability to adapt and change midstream. METHODS: We propose two innovations for pragmatic trial design. RESULTS: Evidence-based evolutionary testing, a framework that allows adaptation of interventions and rapid-cycle innovation, preserves the power of randomization while acknowledging the need for adaptation and learning...
October 2016: Clinical Trials: Journal of the Society for Clinical Trials
Yang Wang, Lu Wang, Huanhuan Chen, Xiaoya Hu, Shengqian Ma
This paper describes the immobilization of gold nanoparticles on metal-metalloporphyrin frameworks (AuNPs/MMPF-6(Fe)) through electrostatic adsorption. The composites were characterized by powder X-ray diffraction, zeta potential, transmission electron microscopy, electrochemical impedance spectroscopy, and voltammetric methods. MMPF-6(Fe) exhibited a pair of redox peaks of the Fe(III)TCPP/Fe(II)TCPP redox couple. The AuNPs/MMPF-6(Fe)-based electrochemical sensor demonstrates a distinctly higher electrocatalytic response to the oxidation of hydroxylamine due to the synergic effect of the gold metal nanoparticles and metal-metalloporphyrin matrix...
July 20, 2016: ACS Applied Materials & Interfaces
Nityananda Sahu, Gurmeet Singh, Apurba Nandi, Shridhar R Gadre
Owing to the steep scaling behavior, highly accurate CCSD(T) calculations, the contemporary gold standard of quantum chemistry, are prohibitively difficult for moderate- and large-sized water clusters even with the high-end hardware. The molecular tailoring approach (MTA), a fragmentation-based technique is found to be useful for enabling such high-level ab initio calculations. The present work reports the CCSD(T) level binding energies of many low-lying isomers of large (H2O)n (n = 16, 17, and 25) clusters employing aug-cc-pVDZ and aug-cc-pVTZ basis sets within the MTA framework...
July 21, 2016: Journal of Physical Chemistry. A
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"