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https://www.readbyqxmd.com/read/28814852/prognostic-variables-and-scores-identifying-the-end-of-life-in-copd-a-systematic-review
#1
REVIEW
Laura-Jane E Smith, Elizabeth Moore, Ifrah Ali, Liam Smeeth, Patrick Stone, Jennifer K Quint
INTRODUCTION: COPD is a major cause of mortality, and the unpredictable trajectory of the disease can bring challenges to end-of-life care. We aimed to investigate known prognostic variables and scores that predict prognosis in COPD in a systematic literature review, specifically including variables that contribute to risk assessment of patients for death within 12 months. METHODS: We conducted a systematic review on prognostic variables, multivariate score or models for COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28807338/molecular-pathology-diagnosis-of-diffuse-large-b-cell-lymphoma-using-biomed-2-clonal-gene-rearrangements
#2
Saeid Ghorbian
BACKGROUND: Clonality testing for immunoglobulin gene rearrangement analysis could be implemented effectively as a useful technique for conventional diagnosis of lymphoma. The European Biomedicine and Health Concerted Action Project BMH4-CT98-3936 (BIOMED-2) have been suggested a gold standard method to clonality detection. OBJECTIVES: We tested empirically clonality rearrangements of IGH and incomplete IGH D-J, on formalin-fixed, paraffin embedded (FFPE) tissue of patients with diffuse large B cell lymphoma (DLBCL)...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28797270/implementing-the-teen-marijuana-check-up-in-schools-a-study-protocol
#3
Bryan Hartzler, Aaron R Lyon, Denise D Walker, Lauren Matthews, Kevin M King, Kathryn E McCollister
BACKGROUND: Substance misuse is now encountered in settings beyond addiction specialty care, with schools a point-of-contact for student access to behavioral health services. Marijuana is a leading impetus for adolescent treatment admissions despite declining risk perception, for which the Teen Marijuana Check-Up (TMCU)-a tailored adaptation of motivational enhancement therapy-offers an efficacious service option. To bridge the knowledge gap concerning effective and affordable technical assistance strategies for implementing empirically supported services, the described trial will test such a strategy to facilitate school-based TMCU implementation...
August 10, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28765653/-adaptation-and-validation-of-five-scales-to-measure-determinants-of-binge-drinking-in-adolescents
#4
M Lima-Serrano, A M Vargas-Martínez, E Gil García, J M Martínez-Montilla, J S Lima Rodríguez, H De Vries
BACKGROUND: The aim of this study was to validate five scales, based on a theoretical framework for the adoption of behaviours, designed to assess the determinants in binge drinking in adolescents, namely: attitude, social influence (model, norm and pressure) and self-efficacy. METHODS: Observational, cross-sectional and multicentre study. Through convenience sampling, 397 adolescents between 15 to 18 years old enrolled in secondary schools in Seville and Huelva were included...
July 28, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28721616/the-mining-sector-of-liberia-current-practices-and-environmental-challenges
#5
EDITORIAL
Samuel T K Wilson, Hongtao Wang, Martin Kabenge, Xuejiao Qi
Liberia is endowed with an impressive stock of mineral reserves and has traditionally relied on mining, namely iron ore, gold, and diamonds, as a major source of income. The recent growth in the mining sector has the potential to contribute significantly to employment, income generation, and infrastructure development. However, the development of these mineral resources has significant environmental impacts that often go unnoticed. This paper presents an overview of the Liberian mining sector from historical, current development, and economic perspectives...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28709012/de-escalation-of-aggressive-behaviour-in-healthcare-settings-concept-analysis
#6
REVIEW
Nutmeg Hallett, Geoffrey L Dickens
BACKGROUND: De-escalation is the recommended first-line response to potential violence and aggression in healthcare settings. Related scholarly activity has increased exponentially since the 1980s, but there is scant research about its efficacy and no guidance on what constitutes the gold standard for practice. OBJECTIVES: To clarify the concept of de-escalation of violence and aggression as described within the healthcare literature. DESIGN: Concept analysis guided by Rodgers' evolutionary approach...
July 4, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28698381/reasons-for-computerised-provider-order-entry-cpoe-based-inpatient-medication-ordering-errors-an-observational-study-of-voided-orders
#7
Joanna Abraham, Thomas G Kannampallil, Alan Jarman, Shivy Sharma, Christine Rash, Gordon Schiff, William Galanter
OBJECTIVE: Medication voiding is a computerised provider order entry (CPOE)-based discontinuation mechanism that allows clinicians to identify erroneous medication orders. We investigated the accuracy of voiding as an indicator of clinician identification and interception of a medication ordering error, and investigated reasons and root contributors for medication ordering errors. METHOD: Using voided orders identified with a void alert, we conducted interviews with ordering and voiding clinicians, followed by patient chart reviews...
July 11, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28677458/nursingstandard-com
#8
(no author information available yet)
1 Under a new university ranking scheme created by the Teaching Excellence Framework, several institutions with renowned nursing schools have failed to achieve a gold level standard. Read more: rcni.com/gold-standard.
July 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28676980/clinical-and-radiological-outcome-at-10-years-of-follow-up-after-total-cervical-disc-replacement
#9
Christoph Mehren, Franziska Heider, Christoph J Siepe, Bernhard Zillner, Ralph Kothe, Andreas Korge, H Michael Mayer
PURPOSE: Previous studies have demonstrated that total cervical disc replacement (cTDR) represents a viable treatment alternative to the 'gold standard' anterior cervical discectomy and fusion for the treatment of well-defined cervical pathologies at short- and mid-term follow-up (FU). However, the implementation and acceptance of a non-fusion philosophy is closely associated with its avoidance of adjacent segment degeneration. Proof of the functional sustainability and clinical improvement of symptoms at long-term FU is still pending...
July 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28676255/an-ontology-based-approach-to-patient-follow-up-assessment-for-continuous-and-personalized-chronic-disease-management
#10
Yi-Fan Zhang, Ling Gou, Tian-Shu Zhou, De-Nan Lin, Jing Zheng, Ye Li, Jing-Song Li
OBJECTIVE: Chronic diseases are complex and persistent clinical conditions that require close collaboration among patients and health care providers in the implementation of long-term and integrated care programs. However, current solutions focus partially on intensive interventions at hospitals rather than on continuous and personalized chronic disease management. This study aims to fill this gap by providing computerized clinical decision support during follow-up assessments of chronically ill patients at home...
July 1, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28664537/a-framework-for-the-meta-analysis-of-bland-altman-studies-based-on-a-limits-of-agreement-approach
#11
Elizabeth Tipton, Jonathan Shuster
Bland-Altman method comparison studies are common in the medical sciences and are used to compare a new measure to a gold-standard (often costlier or more invasive) measure. The distribution of these differences is summarized by two statistics, the 'bias' and standard deviation, and these measures are combined to provide estimates of the limits of agreement (LoA). When these LoA are within the bounds of clinically insignificant differences, the new non-invasive measure is preferred. Very often, multiple Bland-Altman studies have been conducted comparing the same two measures, and random-effects meta-analysis provides a means to pool these estimates...
June 29, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28629337/validity-and-reliability-of-electroacoustic-probe-for-diagnosis-of-developmental-dysplasia-of-the-hip
#12
Nicolas Padilla-Raygoza, Georgina Olvera-Villanueva, Silvia Del Carmen Delgado-Sandoval, Teodoro Cordova-Fraga, Modesto Antonio Sosa-Aquino, Vicente Beltran-Campos
BACKGROUND: Sound transmission is used in the diagnosis of hip dysplasia since the end of the 80's. Aim of this study is to quantify the validity and reliability of electroacoustic probe for the diagnosis of hip dysplasia in neonates. METHODS: Diagnostic study included neonates aged 4-28 days, whose parents signed an informed consent. The probe was used three times for comparative sound transmission and with extension/flexion; hip ultrasound was performed with Graf technique as gold standard...
June 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28600905/omics-data-complementarity-underlines-functional-cross-communication-in-yeast
#13
Noël Malod-Dognin, Nataša Pržulj
Mapping the complete functional layout of a cell and understanding the cross-talk between different processes are fundamental challenges. They elude us because of the incompleteness and noisiness of molecular data and because of the computational intractability of finding the exact answer. We perform a simple integration of three types of baker's yeast omics data to elucidate the functional organization and lines of cross-functional communication. We examine protein-protein interaction (PPI), co-expression (COEX) and genetic interaction (GI) data, and explore their relationship with the gold standard of functional organization, the Gene Ontology (GO)...
June 10, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28589853/n-of-1-pathways-mixenrich-advancing-precision-medicine-via-single-subject-analysis-in-discovering-dynamic-changes-of-transcriptomes
#14
Qike Li, A Grant Schissler, Vincent Gardeux, Ikbel Achour, Colleen Kenost, Joanne Berghout, Haiquan Li, Hao Helen Zhang, Yves A Lussier
BACKGROUND: Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions, these methods are not designed to address single-patient transcriptome analyses. We previously developed and validated the N-of-1-pathways framework using two methods, Wilcoxon and Mahalanobis Distance (MD), for personal transcriptome analysis derived from a pair of samples of a single patient...
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28586407/a-bayesian-hierarchical-model-for-network-meta-analysis-of-multiple-diagnostic-tests
#15
Xiaoye Ma, Qinshu Lian, Haitao Chu, Joseph G Ibrahim, Yong Chen
To compare the accuracy of multiple diagnostic tests in a single study, three designs are commonly used (i) the multiple test comparison design; (ii) the randomized design, and (iii) the non-comparative design. Existing meta-analysis methods of diagnostic tests (MA-DT) have been focused on evaluating the performance of a single test by comparing it with a reference test. The increasing number of available diagnostic instruments for a disease condition and the different study designs being used have generated the need to develop efficient and flexible meta-analysis framework to combine all designs for simultaneous inference...
June 6, 2017: Biostatistics
https://www.readbyqxmd.com/read/28554319/cyclometalated-complexes-of-platinum-and-gold-with-biological-properties-state-of-the-art-and-future-perspectives
#16
Sophie Jürgens, Fritz E Kühn, Angela Casini
BACKGROUND: The inherent problems accompanying chemotherapy necessitate the development of new anticancer approaches. The development of compounds that can disrupt cancerous cellular machinery by novel mechanisms, via interactions with proteins and non-canonical DNA structures (e.g. G-quadruplexes), as well as by alteration of the intracellular redox balance, is nowadays focus of intense research. In this context organometallic compounds of the noble metals Pt and Au have become prominent experimental therapeutic agents...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28549410/large-scale-tissue-histopathology-image-classification-segmentation-and-visualization-via-deep-convolutional-activation-features
#17
Yan Xu, Zhipeng Jia, Liang-Bo Wang, Yuqing Ai, Fang Zhang, Maode Lai, Eric I-Chao Chang
BACKGROUND: Histopathology image analysis is a gold standard for cancer recognition and diagnosis. Automatic analysis of histopathology images can help pathologists diagnose tumor and cancer subtypes, alleviating the workload of pathologists. There are two basic types of tasks in digital histopathology image analysis: image classification and image segmentation. Typical problems with histopathology images that hamper automatic analysis include complex clinical representations, limited quantities of training images in a dataset, and the extremely large size of singular images (usually up to gigapixels)...
May 26, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28501033/the-portuguese-version-of-the-european-deprivation-index-an-instrument-to-study-health-inequalities
#18
Ana Isabel Ribeiro, Alexandra Mayer, Ana Miranda, Maria Fátima Pina
INTRODUCTION: Tackling socioeconomic health inequalities is a big public health challenge and ecological deprivation indexes are essential instruments to monitor and understand them. In Portugal, no standard ecological deprivation index exists, contrasting with other countries. We aimed to describe the construction of the Portuguese version of a transnational deprivation index, European Deprivation Index. MATERIAL AND METHODS: The European Deprivation Index was developed under the Townsend theorization of deprivation...
January 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28500478/effect-of-stenosis-eccentricity-on-the-functionality-of-coronary-bifurcation-lesions-a-numerical-study
#19
Catherine Pagiatakis, Jean-Claude Tardif, Philippe L L'Allier, Rosaire Mongrain
Interventional cardiologists still rely heavily on angiography for the evaluation of coronary lesion severity, despite its poor correlation with the presence of ischemia. In order to improve the accuracy of the current diagnostic procedures, an understanding of the relative influence of geometric characteristics on the induction of ischemia is required. This idea is especially important for coronary bifurcation lesions (CBLs), whose treatment is complex and is associated with high rates of peri- and post-procedural clinical events...
May 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28499990/a-state-space-and-density-estimation-framework-for-sleep-staging-in-obstructive-sleep-apnea
#20
Dae Y Kang, Pamela N DeYoung, Atul Malhotra, Robert L Owens, Todd P Coleman
OBJECTIVE: Although the importance of sleep is increasingly recognized, the lack of robust and efficient algorithms hinders scalable sleep assessment in healthy persons and those with sleep disorders. Polysomnography (PSG) and visual/manual scoring remain the gold standard in sleep evaluation, but more efficient/automated systems are needed. Most previous works have demonstrated algorithms in high agreement with the gold standard in healthy/normal (HN) individuals - not those with sleep disorders...
May 8, 2017: IEEE Transactions on Bio-medical Engineering
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