Kristen Overton, Vidthyia Mennon, Nomvuyo Mothobi, Blake Neild, Elena Martinez, Jeffrey Masters, Peter Grant, Zakir Akhunji, Wei-Yuen Su, Adrienne Torda, Claudia M Whyte, Andrew Lloyd, Chris Weatherall, Ann Hofmeyr, Hong Foo, Kim Brookes, Debbie Marriott, Vitali Sintchenko, Kate Clezy, Pam Konecny, Jeffrey J Post
There is a global outbreak of infections due to Mycobacterium chimaera associated with cardiac surgery. The most serious infections involve prosthetic material implantation, and all have followed surgical procedures involving cardiopulmonary bypass. We describe a cluster of four cases following cardiac surgery at a tertiary referral centre in Sydney, Australia. We report novel clinical findings, including haemolysis and kidney rupture possibly related to immune reconstitution inflammatory syndrome. The positive effect of corticosteroids on haemodynamic function in two cases and the failure of currently recommended antimicrobial therapy to sterilise prosthetic valve material in the absence of surgery despite months of treatment are also critically examined...
December 2018: Internal Medicine Journal