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Deepal Dalal, Christian Curry, Ryan Carter, Colin Zdenek, Nicholas W Todd, Shannon M Rush, Richard Jensen
Midfoot injuries are the second most common athletic foot injury documented in the published data. High-energy Lisfranc dislocations are commonly seen secondary to traumatic etiologies and disrupt the strong midfoot ligaments supporting the arch. These injuries require immediate surgical intervention to prevent serious complications such as compartment syndrome and amputation. The present case series reports a new Lapidus plate system used in 3 patients who underwent arthrodesis procedures for Lisfranc joint dislocation...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Shannon Halloway, Konstantinos Arfanakis, JoEllen Wilbur, Michael E Schoeny, Susan J Pressler
Objectives: Physical activity (PA) is a modifiable health behavior that can protect against age-related gray matter atrophy and cognitive dysfunction. Current studies of PA and gray matter failed to utilize device measures of PA and do not focus on adults >80 years. Thus, the purpose of this secondary analysis was to examine cross-sectional associations between accelerometer lifestyle PA and (a) gray matter volumes and (b) cognitive function, controlling for demographics and health status...
February 8, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Natalie Coriaty, Katherine Pettibone, Nicholas Todd, Shannon Rush, Ryan Carter, Colin Zdenek
Shortening of the first ray is a potential complication associated with first metatarsal procedures. Correction of this deformity conventionally has required the use of a tricortical bone graft to lengthen the bone. Graft complications, including donor site morbidity, poor graft stability, and graft resorption, have revealed a need for an alternative procedure. The present report shows that titanium cage scaffolding has lower extremity applications beyond its previous uses in the ankle and spine. Two patients underwent surgical correction for failed first ray procedures using a titanium cage apparatus with a calcaneal autograft and other biologic agents...
January 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Adina Landsberg, Kate Shannon, Andrea Krüsi, Kora DeBeck, M-J Milloy, Ekaterina Nosova, Thomas Kerr, Kanna Hayashi
Previous research indicates that criminalization of sex work is associated with harms among sex workers. In 2013, the Vancouver Police Department changed their sex work policy to no longer target sex workers while continuing to target clients and third parties in an effort to increase the safety of sex workers (similar to "end-demand sex work" approaches being adopted in a number of countries globally). We sought to investigate the trends and correlates of rushing negotiations with clients due to police presence among 359 sex workers who use drugs in Vancouver before and after the guideline change...
August 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Shannon K Rush, Mirna N Toukatly, Mark R Kilgore, Renata R Urban
BACKGROUND: Pulmonary adenocarcinoma rarely spreads to the gynecologic tract, and has not been fully reported to metastasize within a leiomyoma. CASE: A 47 year-old woman with recurrent pulmonary adenocarcinoma was incidentally found to have a positron emission tomography (PET) avid pelvic mass at the time of restaging. She was also noted to be anemic, and reported significant vaginal bleeding. She was taken for an uncomplicated hysterectomy. She was unexpectedly found to have adenocarcinoma within a leiomyoma, consistent with metastasis from her primary pulmonary adenocarcinoma...
May 2017: Gynecologic Oncology Reports
Katherine A Muldoon, Monica Akello, Godfrey Muzaaya, Annick Simo, Jean Shoveller, Kate Shannon
Sex workers in sub-Saharan Africa experience a high burden of HIV with a paucity of data on violence and links to HIV risk among sex workers, and even less within conflict-affected environments. Data are from a cross-sectional survey of female sex workers in Gulu, northern Uganda (n = 400). Logistic regression was used to determine the specific association between policing and recent physical/sexual violence from clients. A total of 196 (49.0%) sex workers experienced physical/sexual violence by a client...
January 2017: Global Public Health
Kenneth W Hegewald, Matthew D Doyle, Nicholas W Todd, Shannon M Rush
Many surgical procedures have been described for Achilles tendon pathology; however, no overwhelming consensus has been reached for surgical treatment. Open repair using a central or paramedian incision allows excellent visualization for end-to-end anastomosis in the case of a complete rupture and detachment and reattachment for insertional pathologies. Postoperative wound dehiscence and infection in the Achilles tendon have considerable deleterious effects on overall functional recovery and outcome and sometimes require plastic surgery techniques to achieve coverage...
January 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Margaret Erickson, Shira M Goldenberg, Mirriam Ajok, Katherine A Muldoon, Godfrey Muzaaya, Kate Shannon
OBJECTIVE: To describe the characteristics of female sex workers (FSWs) who do and do not use dual contraceptives (i.e. male condoms plus a non-barrier method) in Gulu, northern Uganda. METHODS: The present analysis was based on data gathered as part of a questionnaire-based, cross-sectional study conducted between May 2011 and January 2012. FSWs aged 14 years or older were recruited through peer-led or sex worker-led outreach and community-based services. Logistic regression was used to identify correlates of dual contraceptive use...
October 2015: International Journal of Gynaecology and Obstetrics
Carroll Jones, Shannon Rush, Gregory C Berlet, Jeremy Regina, Murray Penner, Stephen A Brigido, W Bret Smith, Stephen A Brigido
No abstract text is available yet for this article.
June 2015: Foot & Ankle Specialist
Steven M Falowski, Daniel J DiLorenzo, Larry R Shannon, David J Wallace, James Devries, Robert G Kellogg, Nicholas P Cozzi, Lou F Fogg, Richard W Byrne
BACKGROUND: Surgical intervention is an important therapeutic option for patients with intractable epilepsy and a well-characterized epileptogenic focus. Invasive monitoring with subdural electrodes is an effective technique for localizing epileptogenic foci. Previous studies reported varying complication rates, and these may deter more widespread adoption. We present potentially valuable technical nuances that may be associated with low complication rates. We assess the potential contribution of specific aspects of surgical technique to the reduction of complication rates...
October 2015: World Neurosurgery
Guillermo Garcia-Manero, Hanna J Khoury, Elias Jabbour, Jeffrey Lancet, Shannon L Winski, LouAnn Cable, Selena Rush, Lara Maloney, Grant Hogeland, Mieke Ptaszynski, Monica Cabrero Calvo, Zach Bohannan, Alan List, Hagop Kantarjian, Rami Komrokji
PURPOSE: Data suggest that activity of p38 MAPK and Tie2 kinases is dysregulated in myelodysplastic syndromes (MDS) and may be targets for novel therapies. A phase I study of ARRY-614, an oral dual inhibitor of p38 MAPK and Tie2, was conducted in patients with low or intermediate-1 International Prognostic Scoring System risk MDS to evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary responses by International Working Group 2006 criteria. EXPERIMENTAL DESIGN: Forty-five patients received ARRY-614 either once daily or twice daily in dose escalation (400, 600, 900, or 1,200 mg once daily; 200 or 300 mg twice daily) or expansion cohorts...
March 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Cornelia M Ulrich, Adetunji T Toriola, Erin M Siegel, Hermann Brenner, Jenny Chang-Claude, Clare Abbenhardt, Jana Kotzmann, Xiaoling Song, Robert W Owen, Michael Hoffmeister, Heiko Becher, David Shibata, Kathy Vickers, Shannon K Rush, Karen Makar, Gerd Würtele, Roswitha Haubner, Thomas A Sellers, William Grady
Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls...
2013: Journal of Nutritional Science
A Krüsi, K Pacey, L Bird, C Taylor, J Chettiar, S Allan, D Bennett, J S Montaner, T Kerr, K Shannon
OBJECTIVES: To explore how criminalisation and policing of sex buyers (clients) rather than sex workers shapes sex workers' working conditions and sexual transactions including risk of violence and HIV/sexually transmitted infections (STIs). DESIGN: Qualitative and ethnographic study triangulated with sex work-related violence prevalence data and publicly available police statistics. SETTING: Vancouver, Canada, provides a unique opportunity to evaluate the impact of policies that criminalise clients as the local police department adopted a sex work enforcement policy in January 2013 that prioritises sex workers' safety over arrest, while continuing to target clients...
June 2, 2014: BMJ Open
Brittany Rice, Justin Ross, Nicholas Todd, Louis Caputo, Shannon Rush, Bijayee Shrestha
Metastases to the bones in the foot are extremely uncommon, occurring in approximately 0.01% of all metastatic bone disease. We describe a case of an 82-year-old female with a metastatic pulmonary sarcomatoid carcinoma lesion to the midfoot. This rare and aggressive pulmonary malignancy has a poor prognosis. The purpose of the present case report was to highlight the key roles that medical history and biopsy, combined with a multispecialty approach, play in accurately diagnosing and appropriately treating a patient with metastatic bone disease...
May 2015: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
John H Strickler, Shannon McCall, Andrew B Nixon, John C Brady, Herbert Pang, Christel Rushing, Allen Cohn, Alexander Starodub, Christy Arrowood, Sherri Haley, Kellen L Meadows, Michael A Morse, Hope E Uronis, Gerard C Blobe, S David Hsu, S Yousuf Zafar, Herbert I Hurwitz
PURPOSE: Dasatinib inhibits src family kinases and has anti-angiogenic properties. We conducted a phase I study of dasatinib, capecitabine, oxaliplatin, and bevacizumab (CapeOx/bevacizumab), with an expansion cohort in metastatic colorectal cancer (CRC). METHODS: Patients were enrolled in a dose escalation cohort to establish the maximum tolerated dose (MTD) and the recommended phase II dose (RP2D). Using a "3 + 3" design, twelve patients with advanced solid tumors received dasatinib (50 mg twice daily or 70 mg daily), capecitabine (850 mg/m(2) twice daily, days 1-14), oxaliplatin (130 mg/m(2) on day 1) and bevacizumab (7...
April 2014: Investigational New Drugs
Justin S Ross, Shannon M Rush, Nicholas W Todd, Meagan M Jennings
Surgical treatment of post-traumatic avascular necrosis of the talus coupled with collapse often results in limited treatment options. Of those options, the Blair tibiotalar arthrodesis has been beneficial in preserving limb length and subtalar motion. The complications associated with Blair tibiotalar arthrodesis have led to modifications to improve stability and functional outcomes with rigid internal fixation. We present the case of a 29-year-old female with a history of an open fracture dislocation of the talus 10 years previously, with subsequent development of avascular necrosis of the talus...
November 2013: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Jeffrey E McAlister, Christopher F Hyer, J Michael Miller, Shannon Rush, Amol Saxena, John S Steinberg, Lowell Weil
No abstract text is available yet for this article.
October 2013: Foot & Ankle Specialist
Brittany M Rice, Nicholas W Todd, Richard Jensen, Shannon M Rush, William Rogers
Metastatic lesions of uterine carcinosarcoma most commonly occur in the abdomen and lungs and less frequently in highly vascularized bone. We report a rare case of an 86-year-old female with uterine carcinosarcoma with metastasis to the left calcaneus. The patient had a history of uterine carcinosarcoma with hysterectomy and bilateral salpingo-oophorectomy, along with bilateral pelvic and aortic lymphadenectomy, with no adjuvant therapy. The initial pedal complaint was that of left foot pain. The initial radiographic findings were negative; however, magnetic resonance imaging scans revealed a substantial area of marrow edema in the calcaneus...
May 2014: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
David B Agus, Jenolyn F Alexander, Wadih Arap, Shashanka Ashili, Joseph E Aslan, Robert H Austin, Vadim Backman, Kelly J Bethel, Richard Bonneau, Wei-Chiang Chen, Chira Chen-Tanyolac, Nathan C Choi, Steven A Curley, Matthew Dallas, Dhwanil Damania, Paul C W Davies, Paolo Decuzzi, Laura Dickinson, Luis Estevez-Salmeron, Veronica Estrella, Mauro Ferrari, Claudia Fischbach, Jasmine Foo, Stephanie I Fraley, Christian Frantz, Alexander Fuhrmann, Philippe Gascard, Robert A Gatenby, Yue Geng, Sharon Gerecht, Robert J Gillies, Biana Godin, William M Grady, Alex Greenfield, Courtney Hemphill, Barbara L Hempstead, Abigail Hielscher, W Daniel Hillis, Eric C Holland, Arig Ibrahim-Hashim, Tyler Jacks, Roger H Johnson, Ahyoung Joo, Jonathan E Katz, Laimonas Kelbauskas, Carl Kesselman, Michael R King, Konstantinos Konstantopoulos, Casey M Kraning-Rush, Peter Kuhn, Kevin Kung, Brian Kwee, Johnathon N Lakins, Guillaume Lambert, David Liao, Jonathan D Licht, Jan T Liphardt, Liyu Liu, Mark C Lloyd, Anna Lyubimova, Parag Mallick, John Marko, Owen J T McCarty, Deirdre R Meldrum, Franziska Michor, Shannon M Mumenthaler, Vivek Nandakumar, Thomas V O'Halloran, Steve Oh, Renata Pasqualini, Matthew J Paszek, Kevin G Philips, Christopher S Poultney, Kuldeepsinh Rana, Cynthia A Reinhart-King, Robert Ros, Gregg L Semenza, Patti Senechal, Michael L Shuler, Srimeenakshi Srinivasan, Jack R Staunton, Yolanda Stypula, Hariharan Subramanian, Thea D Tlsty, Garth W Tormoen, Yiider Tseng, Alexander van Oudenaarden, Scott S Verbridge, Jenny C Wan, Valerie M Weaver, Jonathan Widom, Christine Will, Denis Wirtz, Jonathan Wojtkowiak, Pei-Hsun Wu
To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles...
2013: Scientific Reports
Shannon M Rush, Nicholas Todd
The Salto Talaris total ankle replacement is an anatomically designed fixed bearing prosthesis available in the United States based on the successful design of the mobile-bearing Salto prosthesis available outside the United States. The original mobile-bearing design was modified and the mobile-bearing was transferred to the precision instrumentation at the trial phase evaluation. Instrumentation and technique allow the surgeon to determine the functional joint axis before final implantation. The Salto Talaris total ankle replacement design blends minimal bone resection and optimizes surface area, cortical contact, and ultra-high molecular weight polyethylene conformity...
January 2013: Clinics in Podiatric Medicine and Surgery
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