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Epilepsy and stroke

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https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#1
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29770467/anticholinergic-load-negatively-correlates-with-recovery-of-cognitive-activities-of-daily-living-for-geriatric-patients-after-stroke-in-the-convalescent-stage
#2
E Kose, T Hirai, T Seki, S Hidaka, T Hamamoto
WHAT IS KNOWN AND OBJECTIVE: Anticholinergic drugs are associated with risks of falls, confusion and cognitive dysfunction. However, the effect of anticholinergic drug use on rehabilitation outcomes after a stroke is poorly documented. We therefore aimed to establish whether the anticholinergic load was associated with functional recovery among geriatric patients convalescing after stroke. METHOD: Consecutive geriatric stroke patients admitted and discharged from a convalescence rehabilitation ward between 2010 and 2016 were included in this retrospective cohort study...
May 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29755351/gastrodin-attenuates-bilateral-common-carotid-artery-occlusion-induced-cognitive-deficits-via-regulating-a%C3%AE-related-proteins-and-reducing-autophagy-and-apoptosis-in-rats
#3
Bo Liu, Jian-Mei Gao, Fei Li, Qi-Hai Gong, Jing-Shan Shi
Gastrodin (GAS), an active constituent extracted from Gastrodia elata Blume, is used to treat ischemic stroke, epilepsy, dizziness, and dementia for centuries in China. This study examined its effects on vascular dementia (VD) and the underlying molecular mechanisms. VD was established by ligation of bilateral common carotid artery occlusion (BCCAO). A total of 7 days after BCCAO surgery, GAS (15, 30, and 60 mg/kg) was orally administered for 28 consecutive days to evaluate therapeutic effects. Cognitive function was tested by the Morris water maze...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29753575/quantitative-apparent-diffusion-coefficient-mapping-may-predict-seizure-onset-in-children-with-sturge-weber-syndrome
#4
Anna L R Pinto, Yangming Ou, Mustafa Sahin, P Ellen Grant
BACKGROUND: Sturge-Weber syndrome (SWS) is often accompanied by seizures, stroke-like episodes, hemiparesis, and visual field deficits. This study aimed to identify early pathophysiologic changes that exist before the development of clinical symptoms and to evaluate if the apparent diffusion coefficient (ADC) map is a candidate early biomarker of seizure risk in patients with SWS. METHODS: This is a prospective cross-sectional study using quantitative ADC analysis to predict onset of epilepsy...
April 12, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29749918/operative-and-consultative-proportions-of-neurosurgical-disease-worldwide-estimation-from-the-surgeon-perspective
#5
Michael C Dewan, Abbas Rattani, Ronnie E Baticulon, Serena Faruque, Walter D Johnson, Robert J Dempsey, Michael M Haglund, Blake C Alkire, Kee B Park, Benjamin C Warf, Mark G Shrime
OBJECTIVE The global magnitude of neurosurgical disease is unknown. The authors sought to estimate the surgical and consultative proportion of diseases commonly encountered by neurosurgeons, as well as surgeon case volume and perceived workload. METHODS An electronic survey was sent to 193 neurosurgeons previously identified via a global surgeon mapping initiative. The survey consisted of three sections aimed at quantifying surgical incidence of neurological disease, consultation incidence, and surgeon demographic data...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29743967/neuropharmacological-potential-and-delivery-prospects-of-thymoquinone-for-neurological-disorders
#6
REVIEW
Md Jakaria, Duk-Yeon Cho, Md Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Dong-Kug Choi
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments. It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity. In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29729285/chloride-transporters-and-gaba-polarity-in-developmental-neurological-and-psychiatric-conditions
#7
REVIEW
Joran T Schulte, Corette J Wierenga, Hilgo Bruining
Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic inhibition during and beyond brain development. This regulation is mainly dependent on the two co-transporters K+ /Cl- co-transporter KCC2 and Na+ /K+ /Cl- co-transporter NKCC1, whose activity can decrease or increase neuronal chloride concentrations respectively. Altered expression and/or activity of either of these co-transporters has been associated with a wide variety of brain disorders including developmental disorders, epilepsy, schizophrenia and stroke...
May 2, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29729153/epilepsy-after-ishemic-stroke-is-it-worth-administering-anticonvulsants-after-the-first-attack
#8
Mykhailo M Oros, Volodymyr I Smolanka, Nina V Sofilkanich, Olesya I Borovik, Vitaliy V Luts, Pavlo G Andrukh
OBJECTIVE: Introduction: Epileptic attacks frequency in patients after stroke ranges widely from 3 % up to 60 %. Today many aspects of this problem in post-stroke epilepsy haven't been completely studied, regarding the problem of the time for administering antiepileptic drugs (AEDs). The aim of this study was to define the prognosis of symptomatic epilepsy development after stroke depending on the patients taking AEDs after the first epileptic attack. PATIENTS AND METHODS: Materials and methods: We perform a complex examination of 1012 patients (562 males and 450 females) aged from 49 up to 90 who had suffered from ischemic stroke during 2011-2014...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29724661/ifcn-endorsed-practical-guidelines-for-clinical-magnetoencephalography-meg
#9
REVIEW
Riitta Hari, Sylvain Baillet, Gareth Barnes, Richard Burgess, Nina Forss, Joachim Gross, Matti Hämäläinen, Ole Jensen, Ryusuke Kakigi, François Mauguière, Nobukatzu Nakasato, Aina Puce, Gian-Luca Romani, Alfons Schnitzler, Samu Taulu
Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. We provide guidelines for best practices of patient preparation, stimulus presentation, MEG data collection and analysis, as well as for MEG interpretation in routine clinical examinations...
April 17, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29724190/association-between-different-acute-stroke-therapies-and-development-of-post-stroke-seizures
#10
Jillian Naylor, Arthur Thevathasan, Leonid Churilov, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Ziyuan Chen, Xinfeng Liu, Patrick Kwan, Bruce C V Campbell
BACKGROUND: Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may improve post-stroke monitoring and follow-up. METHODS: This was a retrospective, multicentre cohort study conducted at the Royal Melbourne Hospital and Jingling Hospital Nanjing...
May 3, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29720158/a-systematic-review-comparing-neurodevelopmental-outcome-in-term-infants-with-hypoxic-and-vascular-brain-injury-with-and-without-seizures
#11
T R De Haan, J Langeslag, J H van der Lee, A H van Kaam
BACKGROUND: There is increasing evidence that neonatal seizures in term neonates with stroke, asphyxia or brain haemorrhage might be associated with adverse neurodevelopment and development of epilepsy. The extent of this association is not known. The objective of this study was to assess the possible impact of neonatal seizures on these outcomes and if possible calculate a relative risk. METHODS: A systematic review and meta-analysis was performed (study period January 2000-June 2015)...
May 2, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29714813/statin-use-associated-with-lower-risk-of-epilepsy-after-intracranial-hemorrhage-a-population-based-cohort-study
#12
Hung-Wei Lin, Yunn-Fang Ho, Fang-Ju Lin
AIMS: To examine the association between statin use before and after intracranial hemorrhage (ICH) and the risk of post-stroke epilepsy (PSE). METHODS: Patients with new-onset ICH between 2004 and 2012 were identified from the Taiwan National Health Insurance Research Database. The main outcome was the occurrence of epilepsy after stroke. Multivariable Cox regression modeling was used to estimate the association between statin use and the risk of PSE, with post-stroke medication exposures being treated as time-dependent variables...
May 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29713938/the-urgent-neurological-consultation-in-the-population-of-the-province-of-ferrara-italy
#13
Vittorio Govoni, Elena Della Coletta, Elisa Fallica, Edward Cesnik
In the province of Ferrara, Italy, the urgent neurological consultation (UNC) cases in the population correspond to the resident outpatients who undergo a UNC in the ER of the university hospital of Ferrara (UHFe). Thanks to this health organization a retrospective survey identified 612 UNC cases (range of age 7-102 years, median 67,5 years) in the study period giving a period prevalence rate of 173 per 100,000 (95% CI 159.3-187.3) which increased with age (χ2 for trend = 178.4 p < 0.001). The daily UNC cases (range 0-14, mean = 7...
May 1, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29712519/systematic-review-of-health-economic-studies-in-cranial-neurosurgery
#14
Won Hyung A Ryu, Michael M H Yang, Sandeep Muram, W Bradley Jacobs, Steven Casha, Jay Riva-Cambrin
OBJECTIVE As the cost of health care continues to increase, there is a growing emphasis on evaluating the relative economic value of treatment options to guide resource allocation. The objective of this systematic review was to evaluate the current evidence regarding the cost-effectiveness of cranial neurosurgery procedures. METHODS The authors performed a systematic review of the literature using PubMed, EMBASE, and the Cochrane Library, focusing on themes of economic evaluation and cranial neurosurgery following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29706307/reducing-stroke-risk-in-epilepsy
#15
EDITORIAL
Steven Owens
No abstract text is available yet for this article.
April 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702413/risk-of-readmission-for-suicide-attempt-after-epilepsy-hospitalization
#16
Kevin Y Xu, Kyle C Rossi, Anna M Kim, Nathalie Jetté, Ji Yeoun Yoo, Kenneth Hung, Mandip S Dhamoon
OBJECTIVE: The objective of this study was to examine if epilepsy admissions are associated with a higher readmission risk for suicide attempt, independent of psychiatric comorbidity, compared with index admissions for other medical causes. METHODS: The Nationwide Readmissions Database is a nationally representative dataset containing data from roughly 15 million hospital discharges. Analysis of International Classification of Disease Clinical Modification 9 (ICD-9-CM) codes in the year 2013 revealed 58,278 index admissions for epilepsy; this group was compared with admissions for stroke (N=215,821) and common medical causes (N=973,078)...
April 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29701548/global-neurosurgery-the-current-capacity-and-deficit-in-the-provision-of-essential-neurosurgical-care-executive-summary-of-the-global-neurosurgery-initiative-at-the-program-in-global-surgery-and-social-change
#17
Michael C Dewan, Abbas Rattani, Graham Fieggen, Miguel A Arraez, Franco Servadei, Frederick A Boop, Walter D Johnson, Benjamin C Warf, Kee B Park
OBJECTIVE Worldwide disparities in the provision of surgical care result in otherwise preventable disability and death. There is a growing need to quantify the global burden of neurosurgical disease specifically, and the workforce necessary to meet this demand. METHODS Results from a multinational collaborative effort to describe the global neurosurgical burden were aggregated and summarized. First, country registries, third-party modeled data, and meta-analyzed published data were combined to generate incidence and volume figures for 10 common neurosurgical conditions...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29684713/effects-of-depression-and-anxiety-on-quality-of-life-in-five-common-neurological-disorders
#18
Joey C Prisnie, Tolulope T Sajobi, Meng Wang, Scott B Patten, Kirsten M Fiest, Andrew G M Bulloch, Tamara Pringsheim, Samuel Wiebe, Nathalie Jette
BACKGROUND: It is unclear whether anxiety and depression impact health-related quality of life (HRQoL) equally across neurological diseases. This study examines the association between anxiety or depression and HRQoL in select neurological disorders. METHODS: HRQoL was measured using the Short Form Health Survey (SF-12) in neurological patients: epilepsy (n = 279), migraine (n = 268), multiple sclerosis (MS) (n = 222), stroke (n = 204), and Parkinson's disease (PD) (n = 224)...
May 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29681486/novel-naphthyloxy-derivatives-potent-histamine-h-3-receptor-ligands-synthesis-and-pharmacological-evaluation
#19
Dorota Łażewska, Maria Kaleta, Stefanie Hagenow, Szczepan Mogilski, Gniewomir Latacz, Tadeusz Karcz, Annamaria Lubelska, Ewelina Honkisz, Jadwiga Handzlik, David Reiner, Grzegorz Satała, Barbara Filipek, Holger Stark, Katarzyna Kieć-Kononowicz
A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H3 receptor affinity. Most compounds showed high affinities with Ki values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy)pentyl)azepane (11) displayed high affinity for the histamine H3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP assay (IC50  = 312 nM) and in vivo in the rat dipsogenia model (ED50  = 3.68 nM). Moreover, compound 11 showed positive effects on scopolamine induced-memory deficits in mice (at doses of 10 and 15 mg/kg) and an analgesic effect in the formalin test in mice with ED50  = 30...
April 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29681214/pathogenesis-of-epileptic-seizures-and-epilepsy-after-stroke
#20
Huajun Yang, Gary Rajah, Anchen Guo, Yongjun Wang, Qun Wang
Stroke is an important cause of seizures and epilepsy in adults, particularly among the elderly. The incidence of stroke increases yearly as life expectancy increases and the number of patients with post-stroke seizures and epilepsy is also rising. Post-stroke epilepsy accounts for nearly 50% of newly diagnosed epilepsy among patients over 60 years of age. With increasing stroke awareness and advanced treatments, increased attention is paid to post-stroke seizures and epilepsy including its diagnosis and treatment...
April 21, 2018: Neurological Research
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