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https://www.readbyqxmd.com/read/27373520/aberrant-methylation-of-trim58-in-hepatocellular-carcinoma-and-its-potential-clinical-implication
#1
Xueping Qiu, Yifang Huang, Ye Zhou, Fang Zheng
TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implications of TRIM58 methylation in HCC. We analyzed the methylation level of TRIM58 in 181 HCC tissues, 172 matched adjacent non-tumor tissues and 13 normal liver tissues using methylation-sensitive restriction enzyme based quantitative PCR and bisulfite genomic sequencing...
August 2016: Oncology Reports
https://www.readbyqxmd.com/read/27108355/the-epitect-methyl-qpcr-assay-as-novel-age-estimation-method-in-forensic-biology
#2
Shakhawan K Mawlood, Lynn Dennany, Nigel Watson, Benjamin S Pickard
Human aging is associated with epigenetic modification of the genome. DNA methylation at cytosines appears currently as the best characterised modification that occurs during the mammalian lifetime. Such methylation changes at regulatory region can provide insights to track contributor age for criminal investigation. The EpiTect Methyl II PCR system (QIAGEN) was used to compare methylation levels of CpG islands in the promoter regions of a number of age related genes, of which four successfully showed changes across the lifespan (NPTX2, KCNQ1DN, GRIA2 and TRIM58)...
July 2016: Forensic Science International
https://www.readbyqxmd.com/read/26842235/a-novel-epigenetic-signature-for-early-diagnosis-in-lung-cancer
#3
Angel Diaz-Lagares, Jesus Mendez-Gonzalez, David Hervas, Maria Saigi, Maria J Pajares, Diana Garcia, Ana B Crujerias, Ruben Pio, Luis M Montuenga, Javier Zulueta, Ernest Nadal, Antoni Rosell, Manel Esteller, Juan Sandoval
PURPOSE: Lung cancer remains as the leading cause of cancer-related death worldwide, mainly due to late diagnosis. Cytology is the gold-standard method for lung cancer diagnosis in minimally invasive respiratory samples, despite its low sensitivity. We aimed to identify epigenetic biomarkers with clinical utility for cancer diagnosis in minimally/noninvasive specimens to improve accuracy of current technologies. EXPERIMENTAL DESIGN: The identification of novel epigenetic biomarkers in stage I lung tumors was accomplished using an integrative genome-wide restrictive analysis of two different large public databases...
July 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/25856432/transcriptome-markers-of-viral-persistence-in-naturally-infected-andes-virus-bunyaviridae-seropositive-long-tailed-pygmy-rice-rats
#4
Corey L Campbell, Fernando Torres-Perez, Mariana Acuna-Retamar, Tony Schountz
Long-tailed pygmy rice rats (Oligoryzomys longicaudatus) are principal reservoir hosts of Andes virus (ANDV) (Bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the Americas. To develop tools for the study of the ANDV-host interactions, we used RNA-Seq to generate a de novo transcriptome assembly. Splenic RNA from five rice rats captured in Chile, three of which were ANDV-infected, was used to generate an assembly of 66,173 annotated transcripts, including noncoding RNAs. Phylogenetic analysis of selected predicted proteins showed similarities to those of the North American deer mouse (Peromyscus maniculatus), the principal reservoir of Sin Nombre virus (SNV)...
2015: PloS One
https://www.readbyqxmd.com/read/25241935/trim58-degrades-dynein-and-regulates-terminal-erythropoiesis
#5
Christopher S Thom, Elizabeth A Traxler, Eugene Khandros, Jenna M Nickas, Olivia Y Zhou, Jacob E Lazarus, Ana P G Silva, Dolly Prabhu, Yu Yao, Chiaka Aribeana, Serge Y Fuchs, Joel P Mackay, Erika L F Holzbaur, Mitchell J Weiss
TRIM58 is an E3 ubiquitin ligase superfamily member implicated by genome-wide association studies to regulate human erythrocyte traits. Here, we show that Trim58 expression is induced during late erythropoiesis and that its depletion by small hairpin RNAs (shRNAs) inhibits the maturation of late-stage nucleated erythroblasts to anucleate reticulocytes. Imaging flow cytometry studies demonstrate that Trim58 regulates polarization and/or extrusion of erythroblast nuclei. In vitro, Trim58 directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein...
September 29, 2014: Developmental Cell
https://www.readbyqxmd.com/read/24674592/genome-wide-association-studies-for-hematological-traits-in-chinese-sutai-pigs
#6
Feng Zhang, Zhiyan Zhang, Xueming Yan, Hao Chen, Wanchang Zhang, Yuan Hong, Lusheng Huang
BACKGROUND: It has been shown that hematological traits are strongly associated with the metabolism and the immune system in domestic pig. However, little is known about the genetic architecture of hematological traits. To identify quantitative trait loci (QTL) controlling hematological traits, we performed single marker Genome-wide association studies (GWAS) and haplotype analysis for 15 hematological traits in 495 Chinese Sutai pigs. RESULTS: We identified 161 significant SNPs including 44 genome-wide significant SNPs associated with 11 hematological traits by single marker GWAS...
2014: BMC Genetics
https://www.readbyqxmd.com/read/22067257/epigenetic-aging-signature-to-determine-age-in-different-tissues
#7
Carmen M Koch, Wolfgang Wagner
All tissues of the organism are affected by aging. This process is associated with epigenetic modifications such as methylation changes at specific cytosine residues in the DNA (CpG sites). Here, we have identified an Epigenetic-Aging-Signature which is applicable for many tissues to predict donor age. DNA-methylation profiles of various cell types were retrieved from public data depositories - all using the HumanMethylation27 BeadChip platform which represents 27,578 CpG sites. Five datasets from dermis, epidermis, cervical smear, T-cells and monocytes were used for Pavlidis Template Matching to identify 19 CpG sites that are continuously hypermethylated upon aging (R>0...
October 2011: Aging
https://www.readbyqxmd.com/read/21625442/methylation-profile-of-single-hepatocytes-derived-from-hepatitis-b-virus-related-hepatocellular-carcinoma
#8
Ran Tao, Jun Li, Jiaojiao Xin, Jian Wu, Jing Guo, Liyuan Zhang, Longyan Jiang, Wu Zhang, Zhe Yang, Lanjuan Li
BACKGROUND: With the development of high-throughput screening, a variety of genetic alterations has been found in hepatocellular carcinoma (HCC). Although previous studies on HCC methylation profiles have focused on liver tissue, studies using isolated hepatocytes are rare. The heterogeneity of liver composition may impact the genuine methylation status of HCC; therefore, it is important to clarify the methylation profile of hepatocytes to aid in understanding the process of tumorigenesis...
2011: PloS One
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